BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|57242798 acid sphingomyelinase-like phosphodiesterase 3B isoform 1 [Homo sapiens] (455 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|57242798 acid sphingomyelinase-like phosphodiesterase 3B isof... 953 0.0 gi|57242800 acid sphingomyelinase-like phosphodiesterase 3B isof... 710 0.0 gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Hom... 357 9e-99 gi|56117840 sphingomyelin phosphodiesterase 1, acid lysosomal is... 194 2e-49 gi|56117842 sphingomyelin phosphodiesterase 1, acid lysosomal is... 152 6e-37 gi|153251270 calcineurin-like phosphoesterase domain containing ... 31 2.0 gi|219842266 usherin isoform B [Homo sapiens] 30 4.5 gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 30 4.5 gi|39812027 amino-terminal enhancer of split isoform c [Homo sap... 30 5.9 gi|39812019 amino-terminal enhancer of split isoform a [Homo sap... 30 5.9 gi|5706731 amino-terminal enhancer of split isoform b [Homo sapi... 30 5.9 >gi|57242798 acid sphingomyelinase-like phosphodiesterase 3B isoform 1 [Homo sapiens] Length = 455 Score = 953 bits (2464), Expect = 0.0 Identities = 455/455 (100%), Positives = 455/455 (100%) Query: 1 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG 60 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG Sbjct: 1 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG 60 Query: 61 DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR 120 DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR Sbjct: 61 DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR 120 Query: 121 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL 180 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL Sbjct: 121 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL 180 Query: 181 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG 240 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG Sbjct: 181 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG 240 Query: 241 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT 300 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT Sbjct: 241 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT 300 Query: 301 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQ 360 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQ Sbjct: 301 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQ 360 Query: 361 LTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDEACSMQHVCAMRQV 420 LTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDEACSMQHVCAMRQV Sbjct: 361 LTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDEACSMQHVCAMRQV 420 Query: 421 DIDAYTTCLYASGTTPVPQLPLLLMALLGLCTLVL 455 DIDAYTTCLYASGTTPVPQLPLLLMALLGLCTLVL Sbjct: 421 DIDAYTTCLYASGTTPVPQLPLLLMALLGLCTLVL 455 >gi|57242800 acid sphingomyelinase-like phosphodiesterase 3B isoform 2 [Homo sapiens] Length = 373 Score = 710 bits (1832), Expect = 0.0 Identities = 335/335 (100%), Positives = 335/335 (100%) Query: 1 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG 60 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG Sbjct: 1 MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG 60 Query: 61 DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR 120 DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR Sbjct: 61 DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR 120 Query: 121 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL 180 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL Sbjct: 121 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL 180 Query: 181 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG 240 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG Sbjct: 181 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG 240 Query: 241 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT 300 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT Sbjct: 241 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT 300 Query: 301 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLK 335 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLK Sbjct: 301 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLK 335 >gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Homo sapiens] Length = 453 Score = 357 bits (917), Expect = 9e-99 Identities = 172/420 (40%), Positives = 253/420 (60%), Gaps = 8/420 (1%) Query: 14 GGARAEP--GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALI 71 GG P G+FWH+ DLHLDP Y ++ D +VC S+ + GP+GD LCDSP+ LI Sbjct: 29 GGRNPPPAIGQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQLI 88 Query: 72 NSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAA 131 S+ +K E F++WTGD PHVP +L V+ ++ +T I+ +FP+ +V+ A Sbjct: 89 LSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPA 148 Query: 132 LGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVV 191 LGNHD+ P++Q P ++ +YN +A LWKPWL E+I+ +KG FY +K+ RI+ Sbjct: 149 LGNHDYWPQDQLPVVTSKVYNAVANLWKPWLDEEAISTLRKGGFYSQKVTTNPNL-RIIS 207 Query: 192 LNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAWF 251 LNTNLYY N +T + DP QF+WLE L ++ + + VYI+ HVP G+ +QN Sbjct: 208 LNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQNITAM 267 Query: 252 REGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLP 311 RE +NEK + + +K+ VIAGQF+GH H DS +L D G P++++F+ P VTP K+ L Sbjct: 268 REYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLE 327 Query: 312 GVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQLTEAYGVPDAS 371 NNP IR+F+YD L DM+ Y++NL++AN +G W+LEY LT+ Y + D Sbjct: 328 ---KQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQ 384 Query: 372 AHSMHTVLDRIA-GDQSTLQRYYVYNSVSYSAGV-CDEACSMQHVCAMRQVDIDAYTTCL 429 S++ + + D +YY Y VSY + V CD+ C +CA+ +D +Y CL Sbjct: 385 PESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTCDKTCKAFQICAIMNLDNISYADCL 444 >gi|56117840 sphingomyelin phosphodiesterase 1, acid lysosomal isoform 1 precursor [Homo sapiens] Length = 631 Score = 194 bits (492), Expect = 2e-49 Identities = 135/440 (30%), Positives = 202/440 (45%), Gaps = 49/440 (11%) Query: 26 IADLHLDPDYKVSKDPFQVCP-----SAGSQPV--PDAGPWGDYL-CDSPWALINSSIYA 77 + DLH D DY DP P +G P P AG WG+Y CD P + S + Sbjct: 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265 Query: 78 MKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDF 137 + P D + WTGD H + + L + +T L+R+ VY A+GNH+ Sbjct: 266 LGPAGPF-DMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLGPVPVYPAVGNHES 323 Query: 138 HPKNQFPA-------GSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIV 190 P N FP S +Y +A+ W+PWL E++ + G FY P R++ Sbjct: 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALS---PYPGLRLI 380 Query: 191 VLNTNLYYTSNA-LTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKA 249 LN N N L + DP Q QWL L A GD V+I+GH+PPG K+ Sbjct: 381 SLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKS---- 436 Query: 250 WFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGV--PISAMFITPGVTPWK 307 ++ Y ++V ++ +A QFFGH H D F + YD+ + P++ F+ P Sbjct: 437 -----WSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSA---- 487 Query: 308 TTLPGVVNGANNPAIRVFE----YDRATLSLKDMVTYFMNLSQANAQGT-PRWELEYQLT 362 TT G+ NP RV++ Y ++ + D TY +NL+QAN G P W+L Y+ Sbjct: 488 TTYIGL-----NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRAR 542 Query: 363 EAYGVPDASAHSMHTVLDRIAGDQSTLQRY-YVYNSVSYSAGVCDEACSMQHVCAMRQVD 421 E YG+P+ + H ++ R+ GD Q + ++Y+ + C C + +CA Sbjct: 543 ETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSAR 602 Query: 422 IDAYTTC--LYASGTTPVPQ 439 D+ C L G+ P Q Sbjct: 603 ADSPALCRHLMPDGSLPEAQ 622 >gi|56117842 sphingomyelin phosphodiesterase 1, acid lysosomal isoform 2 precursor [Homo sapiens] Length = 587 Score = 152 bits (384), Expect = 6e-37 Identities = 120/439 (27%), Positives = 185/439 (42%), Gaps = 91/439 (20%) Query: 26 IADLHLDPDYKVSKDPFQVCP-----SAGSQPV--PDAGPWGDYL-CDSPWALINSSIYA 77 + DLH D DY DP P +G P P AG WG+Y CD P + S + Sbjct: 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265 Query: 78 MKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDF 137 + P D + WTGD H + + L + +T L+R+ VY A+GNH+ Sbjct: 266 LGPAGPF-DMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLGPVPVYPAVGNHES 323 Query: 138 HPKNQFPA-------GSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIV 190 P N FP S +Y +A+ W+PWL E++ Sbjct: 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL----------------------- 360 Query: 191 VLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW 250 + ++L V T K V+I+GH+PPG K+ + W Sbjct: 361 ---------------------RTLRYLSSVETQEGKR--KVHIIGHIPPGHCLKSWS--W 395 Query: 251 FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGV--PISAMFITPGVTPWKT 308 Y ++V ++ +A QFFGH H D F + YD+ + P++ F+ P T Sbjct: 396 -------NYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSA----T 444 Query: 309 TLPGVVNGANNPAIRVFE----YDRATLSLKDMVTYFMNLSQANAQGT-PRWELEYQLTE 363 T G+ NP RV++ Y ++ + D TY +NL+QAN G P W+L Y+ E Sbjct: 445 TYIGL-----NPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARE 499 Query: 364 AYGVPDASAHSMHTVLDRIAGDQSTLQRY-YVYNSVSYSAGVCDEACSMQHVCAMRQVDI 422 YG+P+ + H ++ R+ GD Q + ++Y+ + C C + +CA Sbjct: 500 TYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARA 559 Query: 423 DAYTTC--LYASGTTPVPQ 439 D+ C L G+ P Q Sbjct: 560 DSPALCRHLMPDGSLPEAQ 578 >gi|153251270 calcineurin-like phosphoesterase domain containing 1 isoform a [Homo sapiens] Length = 314 Score = 31.2 bits (69), Expect = 2.0 Identities = 43/215 (20%), Positives = 80/215 (37%), Gaps = 31/215 (14%) Query: 70 LINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVY 129 L ++ A+ ++ P+P F + GD +P G+ E E L +++R V + Sbjct: 67 LTEQAVQAINKLNPKPKFFVLCGDLIHAMP----GKPWRTEQTEDLKRVLRAVDRAIPLV 122 Query: 130 AALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRI 189 GNHD G+ + E + W ++ + + G + Sbjct: 123 LVSGNHDI--------GNTPTAETVEEFCRTW-GDDYFSFWVGGVLF------------- 160 Query: 190 VVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKA 249 +VLN+ Y + + Q QWL++ L+ A + IV P F E Sbjct: 161 LVLNSQFYENPSKCPSLKQ---AQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDD 217 Query: 250 WFREGFNEKYLKVVRKH--HRVIAGQFFGHHHTDS 282 + ++ K + H + F GH+H ++ Sbjct: 218 DYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNA 252 >gi|219842266 usherin isoform B [Homo sapiens] Length = 5202 Score = 30.0 bits (66), Expect = 4.5 Identities = 29/116 (25%), Positives = 42/116 (36%), Gaps = 22/116 (18%) Query: 301 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKDMVTYFMNLSQANAQGTPRWELEYQ 360 P W T P G P V +A +++ +A G P Sbjct: 4722 PSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNI-------------SAPGKPNG----- 4763 Query: 361 LTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYVYNSVSYSAGVCDEACSMQHVCA 416 + Y + +SAH TVL Q TL + +YS GV EAC+ + C+ Sbjct: 4764 IVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAF--TNYSIGV--EACTCFNCCS 4815 >gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo sapiens] Length = 5537 Score = 30.0 bits (66), Expect = 4.5 Identities = 27/101 (26%), Positives = 41/101 (40%), Gaps = 16/101 (15%) Query: 38 SKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH 97 S D P+ D D DSP +++ +S P+ IL G++ P Sbjct: 4673 SLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPAS---------SPESIL--GEEAPR 4721 Query: 98 VPDEKLG-----EAAVLEIVERLTKLIREVFPDTKVYAALG 133 P G + A+ ++ + + VFPDTK Y ALG Sbjct: 4722 FPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGALG 4762 >gi|39812027 amino-terminal enhancer of split isoform c [Homo sapiens] Length = 196 Score = 29.6 bits (65), Expect = 5.9 Identities = 13/46 (28%), Positives = 27/46 (58%), Gaps = 1/46 (2%) Query: 360 QLTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYV-YNSVSYSAGV 404 ++ + + + A HS+ D++A ++S +QR+YV Y +SY + Sbjct: 28 RIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNI 73 >gi|39812019 amino-terminal enhancer of split isoform a [Homo sapiens] Length = 264 Score = 29.6 bits (65), Expect = 5.9 Identities = 13/46 (28%), Positives = 27/46 (58%), Gaps = 1/46 (2%) Query: 360 QLTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYV-YNSVSYSAGV 404 ++ + + + A HS+ D++A ++S +QR+YV Y +SY + Sbjct: 95 RIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNI 140 >gi|5706731 amino-terminal enhancer of split isoform b [Homo sapiens] Length = 197 Score = 29.6 bits (65), Expect = 5.9 Identities = 13/46 (28%), Positives = 27/46 (58%), Gaps = 1/46 (2%) Query: 360 QLTEAYGVPDASAHSMHTVLDRIAGDQSTLQRYYV-YNSVSYSAGV 404 ++ + + + A HS+ D++A ++S +QR+YV Y +SY + Sbjct: 28 RIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNI 73 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.137 0.438 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,243,628 Number of Sequences: 37866 Number of extensions: 908628 Number of successful extensions: 1746 Number of sequences better than 10.0: 11 Number of HSP's better than 10.0 without gapping: 5 Number of HSP's successfully gapped in prelim test: 6 Number of HSP's that attempted gapping in prelim test: 1725 Number of HSP's gapped (non-prelim): 13 length of query: 455 length of database: 18,247,518 effective HSP length: 106 effective length of query: 349 effective length of database: 14,233,722 effective search space: 4967568978 effective search space used: 4967568978 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.