Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 55925608
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55925608 kelch-like 21 [Homo sapiens]
(597 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55925608 kelch-like 21 [Homo sapiens] 1233 0.0
gi|128485503 kelch-like 30 [Homo sapiens] 352 6e-97
gi|40018614 DRE1 protein [Homo sapiens] 315 1e-85
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 310 2e-84
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 310 2e-84
gi|38194229 kelch-like 17 [Homo sapiens] 275 9e-74
gi|40807500 kelch-like 20 [Homo sapiens] 274 1e-73
gi|109150407 kelch-like 6 [Homo sapiens] 268 1e-71
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 262 8e-70
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 262 8e-70
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 260 2e-69
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 260 2e-69
gi|166235129 kelch-like 3 [Homo sapiens] 255 7e-68
gi|55925604 kelch-like 18 [Homo sapiens] 252 6e-67
gi|40255071 kelch-like 23 [Homo sapiens] 249 5e-66
gi|11056006 kelch-like 12 [Homo sapiens] 249 7e-66
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 248 1e-65
gi|194097389 kelch-like 38 [Homo sapiens] 244 1e-64
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 240 3e-63
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 239 4e-63
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 235 8e-62
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 235 8e-62
gi|14780904 kelch-like 1 protein [Homo sapiens] 229 5e-60
gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 223 4e-58
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 219 4e-57
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 213 4e-55
gi|24308181 kelch-like 9 [Homo sapiens] 211 2e-54
gi|34101268 kelch-like 8 [Homo sapiens] 208 1e-53
gi|8922854 kelch-like 26 [Homo sapiens] 208 1e-53
gi|223890235 intracisternal A particle-promoted polypeptide isof... 207 2e-53
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 1233 bits (3189), Expect = 0.0
Identities = 597/597 (100%), Positives = 597/597 (100%)
Query: 1 MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPY 60
MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPY
Sbjct: 1 MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPY 60
Query: 61 FRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPA 120
FRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPA
Sbjct: 61 FRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPA 120
Query: 121 VKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR 180
VKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR
Sbjct: 121 VKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR 180
Query: 181 LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEA 240
LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEA
Sbjct: 181 LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEA 240
Query: 241 EPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDE 300
EPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDE
Sbjct: 241 EPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDE 300
Query: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360
LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN
Sbjct: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360
Query: 361 EWAEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTAC 420
EWAEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTAC
Sbjct: 361 EWAEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTAC 420
Query: 421 RGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSA 480
RGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSA
Sbjct: 421 RGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSA 480
Query: 481 EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW 540
EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW
Sbjct: 481 EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW 540
Query: 541 SVVGRLPEPTFWHGSVSIFRQFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH 597
SVVGRLPEPTFWHGSVSIFRQFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH
Sbjct: 541 SVVGRLPEPTFWHGSVSIFRQFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH 597
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 352 bits (903), Expect = 6e-97
Identities = 214/560 (38%), Positives = 302/560 (53%), Gaps = 37/560 (6%)
Query: 21 LLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLH 80
+L GL +LR++ K DVTL GGR+ P HR +LA +SPYF AMFAG ES + RV L
Sbjct: 1 MLDGLQRLRSQPKLADVTL-LVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELR 59
Query: 81 GVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLD 140
V P ++ L+DF YTGR+ ++ N E L R A L FP+V++ CG +LQQQLD ANCL
Sbjct: 60 DVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLG 119
Query: 141 MQDFAEAFSCSGLASAAQRFILRHVGELGAE-QLERLPLARLLRYLRDDGLCVPKEEAAY 199
+ +F E G+A+ A F+ + + E + +LP RL+ L D L V E++
Sbjct: 120 ICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRL 179
Query: 200 QLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARD 259
+ +RWVR DP RAAH P+LL V L V R + + +EPL+ C
Sbjct: 180 EALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEAC--------- 230
Query: 260 FQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDE--------LVTVDCYNPQT 311
+AA HD P + L E+LV+VGG + +E L YN +
Sbjct: 231 -RAALSQGHDGAPLALQQK-----LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKA 284
Query: 312 GQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRL----YDCVWRYNSSVNEWAEVAP 367
+W L +FPD+ G+S+ AL N+IYVTGGS G++ W + W VAP
Sbjct: 285 KRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAP 344
Query: 368 MLKAREYHSSSVLDGLLYVVAADS-----TERYDHTTDSWEALQPMTYPMDNCSTTACRG 422
MLK R H+S+ L+G +YV+ + E YD TDSW + P + N S CRG
Sbjct: 345 MLKPRTNHASAALNGEIYVIGGTTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRG 404
Query: 423 RLYAIGSLAGK-ETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE 481
RLY +GS A K + +QCY+P TD WS++ LP + +P+ A L+G +Y + D++ +
Sbjct: 405 RLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDNTKK 464
Query: 482 VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFE--LSDVVEAYDPETRA 539
V VY+P N W K+ S + +H G+L LG LYV+GG E +EAYD
Sbjct: 465 VYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDT 524
Query: 540 WSVVGRLPEPTFWHGSVSIF 559
W+ G LP +HG+ ++F
Sbjct: 525 WTRHGALPRLWLYHGASTVF 544
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 315 bits (806), Expect = 1e-85
Identities = 188/559 (33%), Positives = 289/559 (51%), Gaps = 21/559 (3%)
Query: 13 SDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRES 72
S +HA ++L+ ++ R R F DV + G++FP HRAVL+A S YFRAMF RES
Sbjct: 44 SGSSHAENILQIFNEFRDSRLFTDVII-CVEGKEFPCHRAVLSACSSYFRAMFCNDHRES 102
Query: 73 RAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQ 132
R V ++G+ + ++ L + YTG+V ++ +N + L + L Q +++AC FL++Q
Sbjct: 103 REMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQ 162
Query: 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLC 191
LD NCL +Q FA+ S L + + F L+ ++ E+ L L+ Y+ D L
Sbjct: 163 LDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELV 222
Query: 192 VPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCL 251
+ KEE ++ +RWV R +LL VRLP + Y + VE + L+ P C
Sbjct: 223 IGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECY 282
Query: 252 RLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQ-DCDELVTVDCYNPQ 310
+LL EAR + + PR RPR STG +E++V+VGGC++ L +CY+P
Sbjct: 283 QLLHEARRYHILGNEMMS----PRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPV 338
Query: 311 TGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLK 370
TG+W+ LA+ P+ Y++ AL NDI V+GG SR VW YNS +N W VA + K
Sbjct: 339 TGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVASLNK 395
Query: 371 AREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGR 423
R H +VL G +YVV S E YD ++ W + P+ + + + T+C G+
Sbjct: 396 GRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGK 455
Query: 424 LYAIGSLAGKETM--VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE 481
L+ IG T +Q YDP+T+ W L +P +LN L+Y +
Sbjct: 456 LFVIGGGPDDNTCSDKVQSYDPETNSWLL--RAAIPIAKRCITAVSLNNLIYVAGGLTKA 513
Query: 482 VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWS 541
+ Y+P + W + + ++V GK+Y+ GG E +D + YDP T +
Sbjct: 514 IYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIIT 573
Query: 542 VVGRLPEPTFWHGSVSIFR 560
V +P P +HG V+I R
Sbjct: 574 GVAAMPRPVSYHGCVTIHR 592
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 310 bits (795), Expect = 2e-84
Identities = 194/569 (34%), Positives = 299/569 (52%), Gaps = 28/569 (4%)
Query: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMF------ 65
F+DP H +L+ L+Q R + F D+ + GR+F H+ VLA+ S YF+ +
Sbjct: 306 FTDPGHPREMLKELNQQRRAKAFTDLKI-VVEGREFEVHQNVLASCSLYFKDLIQRSVQD 364
Query: 66 AGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
+GQ + E V L + D+L+LLL+F YTG + + NA+ LL AA QF + C
Sbjct: 365 SGQGGREKLELV-LSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Query: 126 GAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR--LLR 183
+FL++QL +NCL + AEA CS L A+ F L+ E+ A++ E L +++ +
Sbjct: 424 VSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQE-EILSISKDDFIA 482
Query: 184 YLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPL 243
Y+ +D L EE Y+ ++W++ DP R + +LL VRLPF+ YLL V+ E L
Sbjct: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Query: 244 VARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGG---CDQDCDE 300
+ C L+ EA+ + + R + PR RPR S G+AE++VLVGG
Sbjct: 543 IKSSEACRDLVNEAKRYHMLPHARQEM-QTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS 601
Query: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360
LV V C+NPQ +W LA P + +S+V+ G++IY++GG + VW Y S ++
Sbjct: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
Query: 361 EWAEVAPMLKAREYHSSSVLDGLLYVVA-------ADSTERYDHTTDSWEALQPMTYPMD 413
W V+ M R H+S V DG +Y + D ERYD T+ WEA+ P+ +
Sbjct: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVH 721
Query: 414 NCSTTACRGRLYAIGSL--AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGL 471
+ + T C G++Y G + AG+ V+Q Y P T+ WS ++ + +AP TLNG
Sbjct: 722 SAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDN-KYAP-AVTLNGF 779
Query: 472 MYFVRDDSAE-VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGG-YDNTFELSDV 529
++ + A +Y+P + P+MN S VL GK+Y +GG +
Sbjct: 780 VFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
Query: 530 VEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
+EAY+P T W+++ +P P F HG V I
Sbjct: 840 MEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 310 bits (795), Expect = 2e-84
Identities = 194/569 (34%), Positives = 299/569 (52%), Gaps = 28/569 (4%)
Query: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMF------ 65
F+DP H +L+ L+Q R + F D+ + GR+F H+ VLA+ S YF+ +
Sbjct: 306 FTDPGHPREMLKELNQQRRAKAFTDLKI-VVEGREFEVHQNVLASCSLYFKDLIQRSVQD 364
Query: 66 AGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
+GQ + E V L + D+L+LLL+F YTG + + NA+ LL AA QF + C
Sbjct: 365 SGQGGREKLELV-LSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Query: 126 GAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR--LLR 183
+FL++QL +NCL + AEA CS L A+ F L+ E+ A++ E L +++ +
Sbjct: 424 VSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQE-EILSISKDDFIA 482
Query: 184 YLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPL 243
Y+ +D L EE Y+ ++W++ DP R + +LL VRLPF+ YLL V+ E L
Sbjct: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Query: 244 VARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGG---CDQDCDE 300
+ C L+ EA+ + + R + PR RPR S G+AE++VLVGG
Sbjct: 543 IKSSEACRDLVNEAKRYHMLPHARQEM-QTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS 601
Query: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360
LV V C+NPQ +W LA P + +S+V+ G++IY++GG + VW Y S ++
Sbjct: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
Query: 361 EWAEVAPMLKAREYHSSSVLDGLLYVVA-------ADSTERYDHTTDSWEALQPMTYPMD 413
W V+ M R H+S V DG +Y + D ERYD T+ WEA+ P+ +
Sbjct: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVH 721
Query: 414 NCSTTACRGRLYAIGSL--AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGL 471
+ + T C G++Y G + AG+ V+Q Y P T+ WS ++ + +AP TLNG
Sbjct: 722 SAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDN-KYAP-AVTLNGF 779
Query: 472 MYFVRDDSAE-VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGG-YDNTFELSDV 529
++ + A +Y+P + P+MN S VL GK+Y +GG +
Sbjct: 780 VFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
Query: 530 VEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
+EAY+P T W+++ +P P F HG V I
Sbjct: 840 MEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 275 bits (703), Expect = 9e-74
Identities = 181/535 (33%), Positives = 254/535 (47%), Gaps = 31/535 (5%)
Query: 25 LSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPP 84
+S++R D+ L A ++ AH+ VLA+ SPYF AMF ++ ESR V LH + P
Sbjct: 82 MSRMRQRGLLCDIVLHVAA-KEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDP 140
Query: 85 DMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDF 144
L L+ F+YT + V N + LL AA LLQ V++AC FL QLD +NCL ++ F
Sbjct: 141 QALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGF 200
Query: 145 AEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLAL 203
A+A SCS L AA R++L+H ++ E+ LPL ++L + D L VP EE Y+ L
Sbjct: 201 ADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVL 260
Query: 204 RWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAA 263
WV+ D R H P+L++ VRLP + R +LL HV+AE LV P C LL EA F
Sbjct: 261 SWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLL 320
Query: 264 RYDRHDRGPCPRMRPRPSTGLAEILVLVGG-----CDQDCDELVTVDCYNPQTGQWRYLA 318
R G R RPR G +L VGG DC + Y+ +T +W +A
Sbjct: 321 PEQRGVLG-TSRTRPRRCEGAGPVLFAVGGGSLFAIHGDC------EAYDTRTDRWHVVA 373
Query: 319 EFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSS 378
+ A+GN +Y GG DG+ V Y+ N W M R +
Sbjct: 374 SMSTR-RARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVA 432
Query: 379 VLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSL- 430
L GLLY +S ERYD T +W ++ M+ G LYA+G
Sbjct: 433 ALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYD 492
Query: 431 AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSA-----EVDVY 485
+ ++ Y+P ++WS V L S A A L G +Y + V+ Y
Sbjct: 493 SSSHLATVEKYEPQVNVWSPV-ASMLSRRSSA-GVAVLEGALYVAGGNDGTSCLNSVERY 550
Query: 486 NPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW 540
+P W+ + MN L + G LY GG D + L+ +E Y+P T W
Sbjct: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNS-IEKYNPRTNKW 604
Score = 71.6 bits (174), Expect = 2e-12
Identities = 52/176 (29%), Positives = 76/176 (43%), Gaps = 20/176 (11%)
Query: 382 GLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMV-MQC 440
G L+ + D E YD TD W + M+ A RLYA+G G + ++
Sbjct: 350 GSLFAIHGDC-EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVES 408
Query: 441 YDPDTDLWSLVDCGQLPPWSFAPK-----TATLNGLMYFVRD-DSAE----VDVYNPTRN 490
YDP T+ W P S + A L+GL+Y D A + Y+P
Sbjct: 409 YDPVTNTWQ-------PEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTG 461
Query: 491 EWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRL 546
W + +M+ +A L G LY GGYD++ L+ VE Y+P+ WS V +
Sbjct: 462 TWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLA-TVEKYEPQVNVWSPVASM 516
Score = 47.0 bits (110), Expect = 5e-05
Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 3/105 (2%)
Query: 279 RPSTGLA--EILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGND 336
R S G+A E + V G + L +V+ Y+P+ G W +A + + +VA+
Sbjct: 520 RSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPM-NIRRSTHDLVAMDGW 578
Query: 337 IYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLD 381
+Y GG+DGS + + +YN N+W + M R +VL+
Sbjct: 579 LYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 274 bits (701), Expect = 1e-73
Identities = 183/560 (32%), Positives = 275/560 (49%), Gaps = 31/560 (5%)
Query: 4 PAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRA 63
P P A +P+ H L ++ LR R+ DV L G + AHR +L+A SPYFRA
Sbjct: 38 PQP-ARMPYISDKHPRQTLEVINLLRKHRELCDVVL-VVGAKKIYAHRVILSACSPYFRA 95
Query: 64 MFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKE 123
MF G+L ESR V + + ++LL+DF+YT ++ V N + LL AA LLQ ++E
Sbjct: 96 MFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQE 155
Query: 124 ACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLL 182
AC FL++QLD +NCL ++ FA+ SC L A +F + E + +E+ LP +L+
Sbjct: 156 ACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLI 215
Query: 183 RYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEP 242
+ D L V EE + + WV+ R PQ+L+ VRLP + +L+ V ++P
Sbjct: 216 DIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDP 275
Query: 243 LVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGG-CDQDCDEL 301
L+ C L+ EA+++ +R PR RPR E+L VGG C D +
Sbjct: 276 LIKSDEECRDLVDEAKNYLLLPQER-PLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA--I 332
Query: 302 VTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNE 361
+V+ Y+PQT +WR +A G + L + +Y GG DGS + V RY+ N+
Sbjct: 333 SSVERYDPQTNEWRMVASMSKR-RCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQ 391
Query: 362 W-AEVAPMLKAREYHSSSVLDGLLYVVAADS-------TERYDHTTDSWEALQPMTYPMD 413
W ++VAP R +VL G LY V ERYD + W + M+
Sbjct: 392 WSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRL 451
Query: 414 NCSTTACRGRLYAIGSLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPK---TATLN 469
+ G LYA+G G + ++ Y+P + W + P K A
Sbjct: 452 GVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTI-----APMGTRRKHLGCAVYQ 506
Query: 470 GLMYFV--RDDSAEV---DVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTF 524
++Y V RDD+ E+ + YNP N+W + +M G LAV+ G+L GG+D T
Sbjct: 507 DMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTT 566
Query: 525 ELSDVVEAYDPETRAWSVVG 544
L +E +DP+ W + G
Sbjct: 567 YLK-TIEVFDPDANTWRLYG 585
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 10/134 (7%)
Query: 420 CRGRLYAIGS-LAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--R 476
C L+A+G +G ++ YDP T+ W +V + + L+ L+Y V
Sbjct: 316 CGEVLFAVGGWCSGDAISSVERYDPQTNEWRMV--ASMSKRRCGVGVSVLDDLLYAVGGH 373
Query: 477 DDSA---EVDVYNPTRNEWDK-IPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEA 532
D S+ V+ Y+P N+W + + +AVLGG LY GG D L+ +VE
Sbjct: 374 DGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLN-IVER 432
Query: 533 YDPETRAWSVVGRL 546
YDP+ W+ V +
Sbjct: 433 YDPKENKWTRVASM 446
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 268 bits (684), Expect = 1e-71
Identities = 172/573 (30%), Positives = 280/573 (48%), Gaps = 35/573 (6%)
Query: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71
F D +L L GL LR E DV L ++F HR VLAAAS YFRAMF L+E
Sbjct: 49 FDDAGLSLILQNGLETLRMENALTDVIL-CVDIQEFSCHRVVLAAASNYFRAMFCNDLKE 107
Query: 72 SRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
+R+ + GV + + LLD++YT + ++ N + +L AA+L QF + +AC +FL +
Sbjct: 108 KYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTE 167
Query: 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRH-VGELGAEQLERLPLARLLRYLRDDGL 190
L+ NC+ + A+ S L Q +I+++ V L +E+ LP+ L L+ D L
Sbjct: 168 ALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDL 227
Query: 191 CVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPC 250
V +E ++ + WVR P R P +LE VRLP + +Y + VEA+PL+ +CP
Sbjct: 228 YVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEV 287
Query: 251 LRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQ 310
LL+EAR + + + R +PR +E+ +++GGC +D + V C +P
Sbjct: 288 FPLLQEARMYHLSGNEIISE----RTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPL 343
Query: 311 TGQWRYLAEFP---------DHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNE 361
+A+ P + ++ V L N++Y++GG + VW+YNSS+N+
Sbjct: 344 RRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQH---DVWKYNSSINK 400
Query: 362 WAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDN 414
W ++ + R H VL G +YV+ ++ E YD + W P+ + +
Sbjct: 401 WIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSS 460
Query: 415 CSTTACRGRLYAI-----GSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLN 469
+ T+ + +LY I G LA +T QCYDP T+ WSL +P + +
Sbjct: 461 FAATSHKKKLYVIGGGPNGKLATDKT---QCYDPSTNKWSLK--AAMPVEAKCINAVSFR 515
Query: 470 GLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDV 529
+Y V + Y+P + W + ++ +A +LY++GG D E+
Sbjct: 516 DRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIAT 575
Query: 530 VEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQF 562
V +DPE + + LP HGSV+I + +
Sbjct: 576 VLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSY 608
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 262 bits (669), Expect = 8e-70
Identities = 173/558 (31%), Positives = 272/558 (48%), Gaps = 27/558 (4%)
Query: 2 ERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYF 61
E+ P+ V P+ H + +++LR++ DVT+ A + AHR VLAA SPYF
Sbjct: 31 EKHCPVTVNPW----HMKKAFKVMNELRSQNLLCDVTI-VAEDMEISAHRVVLAACSPYF 85
Query: 62 RAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAV 121
AMF G++ ESRA+RVR+ V L++L+D+ YT + V+ +N + LL AA LLQ V
Sbjct: 86 HAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDV 145
Query: 122 KEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLAR 180
K+ C FL+ QL NCL ++ FA+ +C+ L + A + +H ++ +E+ L + +
Sbjct: 146 KKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQ 205
Query: 181 LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEA 240
+ + D L + EE ++ + WV D R +L+E VRLP + R YL+ VE
Sbjct: 206 VCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEE 265
Query: 241 EPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDE 300
E LV C L EA + ++ R R R L +++V+VGG Q
Sbjct: 266 EALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKA 323
Query: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360
+ +V+CY+ + +W +AE P +V + ++ GG +GS V Y+ +
Sbjct: 324 IRSVECYDFKEERWHQVAELPSRRCRA-GMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKD 382
Query: 361 EWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMD 413
+W VA M R ++VL+GLLY V S E Y+ ++ W + PM
Sbjct: 383 QWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 442
Query: 414 NCSTTACRGRLYAIGSLAGKETM---VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNG 470
+ G LYA+G G ++CY+ T+ W+ + ++ LN
Sbjct: 443 SVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYI--AEMSTRRSGAGVGVLNN 500
Query: 471 LMYFVRDDSA-----EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFE 525
L+Y V V+VY+PT N W ++ MN + + G LYV GG D +
Sbjct: 501 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN 560
Query: 526 LSDVVEAYDPETRAWSVV 543
L+ VE Y+P T W+VV
Sbjct: 561 LAS-VEYYNPTTDKWTVV 577
Score = 43.9 bits (102), Expect = 4e-04
Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 3/99 (3%)
Query: 284 LAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGS 343
L +L VGG D +V+ Y+P T WR +A+ + + A+ +YV GG
Sbjct: 498 LNNLLYAVGGHDGPLVRK-SVEVYDPTTNAWRQVADM-NMCRRNAGVCAVNGLLYVVGGD 555
Query: 344 DGSRLYDCVWRYNSSVNEWAEVAP-MLKAREYHSSSVLD 381
DGS V YN + ++W V+ M R Y +V+D
Sbjct: 556 DGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVID 594
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 262 bits (669), Expect = 8e-70
Identities = 173/558 (31%), Positives = 272/558 (48%), Gaps = 27/558 (4%)
Query: 2 ERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYF 61
E+ P+ V P+ H + +++LR++ DVT+ A + AHR VLAA SPYF
Sbjct: 27 EKHCPVTVNPW----HMKKAFKVMNELRSQNLLCDVTI-VAEDMEISAHRVVLAACSPYF 81
Query: 62 RAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAV 121
AMF G++ ESRA+RVR+ V L++L+D+ YT + V+ +N + LL AA LLQ V
Sbjct: 82 HAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDV 141
Query: 122 KEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLAR 180
K+ C FL+ QL NCL ++ FA+ +C+ L + A + +H ++ +E+ L + +
Sbjct: 142 KKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQ 201
Query: 181 LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEA 240
+ + D L + EE ++ + WV D R +L+E VRLP + R YL+ VE
Sbjct: 202 VCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEE 261
Query: 241 EPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDE 300
E LV C L EA + ++ R R R L +++V+VGG Q
Sbjct: 262 EALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKA 319
Query: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360
+ +V+CY+ + +W +AE P +V + ++ GG +GS V Y+ +
Sbjct: 320 IRSVECYDFKEERWHQVAELPSRRCRA-GMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKD 378
Query: 361 EWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMD 413
+W VA M R ++VL+GLLY V S E Y+ ++ W + PM
Sbjct: 379 QWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 438
Query: 414 NCSTTACRGRLYAIGSLAGKETM---VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNG 470
+ G LYA+G G ++CY+ T+ W+ + ++ LN
Sbjct: 439 SVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYI--AEMSTRRSGAGVGVLNN 496
Query: 471 LMYFVRDDSA-----EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFE 525
L+Y V V+VY+PT N W ++ MN + + G LYV GG D +
Sbjct: 497 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN 556
Query: 526 LSDVVEAYDPETRAWSVV 543
L+ VE Y+P T W+VV
Sbjct: 557 LAS-VEYYNPTTDKWTVV 573
Score = 43.9 bits (102), Expect = 4e-04
Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 3/99 (3%)
Query: 284 LAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGS 343
L +L VGG D +V+ Y+P T WR +A+ + + A+ +YV GG
Sbjct: 494 LNNLLYAVGGHDGPLVRK-SVEVYDPTTNAWRQVADM-NMCRRNAGVCAVNGLLYVVGGD 551
Query: 344 DGSRLYDCVWRYNSSVNEWAEVAP-MLKAREYHSSSVLD 381
DGS V YN + ++W V+ M R Y +V+D
Sbjct: 552 DGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVID 590
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 260 bits (665), Expect = 2e-69
Identities = 175/553 (31%), Positives = 264/553 (47%), Gaps = 36/553 (6%)
Query: 17 HALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER 76
HA + + ++ DV L AG R PAHR VL++ S YF AMF +RE+R E
Sbjct: 156 HAEQTFKKMENYLRHKQLCDVIL-VAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEE 214
Query: 77 VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
+++ GV P+ L L+ ++YTGR+ + DN E LL A LLQ V EAC FL +QL +
Sbjct: 215 IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPS 274
Query: 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKE 195
NCL ++ FA+A C+ L A + + H E + ++ LP + + + L D + +P E
Sbjct: 275 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 334
Query: 196 EAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLR 255
E L WVR D +R +LL +RLP + + LA +E L C +L+
Sbjct: 335 ETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF-LADMENNVLFRDDIECQKLIM 393
Query: 256 EARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWR 315
EA + +R PR +PR ST L VGG D +++ Y+ +T W
Sbjct: 394 EAMKYHLLP-ERRPMLQSPRTKPRKST--VGTLFAVGGMD-STKGATSIEKYDLRTNMWT 449
Query: 316 YLAEFPDHLGG---GYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
+A ++ G + + L + +YV GG DG + + V YN W+ + PM R
Sbjct: 450 PVA----NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHR 505
Query: 373 EYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLY 425
+VL+G +Y V ++ ER+D W + M+ P G+LY
Sbjct: 506 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 565
Query: 426 AIGSLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE--- 481
A+G G + ++C+DP T+ W+L C Q+ T NGL+Y + A
Sbjct: 566 AVGGRDGSSCLKSVECFDPHTNKWTL--CAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 623
Query: 482 --------VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAY 533
V+ Y+P + W + SM+ + +LG KLY GGYD L + VEAY
Sbjct: 624 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL-NTVEAY 682
Query: 534 DPETRAWSVVGRL 546
DP+T W+ V L
Sbjct: 683 DPQTNEWTQVAPL 695
Score = 56.2 bits (134), Expect = 8e-08
Identities = 42/134 (31%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 422 GRLYAIGSL-AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--RDD 478
G L+A+G + + K ++ YD T++W+ V F A L+ +Y V RD
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFG--VAVLDDKLYVVGGRDG 478
Query: 479 SAE---VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDP 535
V+ YNP W +P M+ G +AVL G +Y GG+D L+ VE +DP
Sbjct: 479 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLN-TVERWDP 537
Query: 536 ETRAWSVVGRLPEP 549
+ R W+ V + P
Sbjct: 538 QARQWNFVATMSTP 551
Score = 48.9 bits (115), Expect = 1e-05
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 12/94 (12%)
Query: 287 ILVLVGGCDQDCDELVT-----VDCYNPQTGQWRYLAEFP---DHLGGGYSIVALGNDIY 338
+L +GG D L + V+ Y+P+T W +A D +G + LG+ +Y
Sbjct: 610 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG----VCLLGDKLY 665
Query: 339 VTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
GG DG + V Y+ NEW +VAP+ R
Sbjct: 666 AVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 699
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 260 bits (665), Expect = 2e-69
Identities = 175/553 (31%), Positives = 264/553 (47%), Gaps = 36/553 (6%)
Query: 17 HALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER 76
HA + + ++ DV L AG R PAHR VL++ S YF AMF +RE+R E
Sbjct: 202 HAEQTFKKMENYLRHKQLCDVIL-VAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEE 260
Query: 77 VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
+++ GV P+ L L+ ++YTGR+ + DN E LL A LLQ V EAC FL +QL +
Sbjct: 261 IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPS 320
Query: 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKE 195
NCL ++ FA+A C+ L A + + H E + ++ LP + + + L D + +P E
Sbjct: 321 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNE 380
Query: 196 EAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLR 255
E L WVR D +R +LL +RLP + + LA +E L C +L+
Sbjct: 381 ETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF-LADMENNVLFRDDIECQKLIM 439
Query: 256 EARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWR 315
EA + +R PR +PR ST L VGG D +++ Y+ +T W
Sbjct: 440 EAMKYHLLP-ERRPMLQSPRTKPRKST--VGTLFAVGGMD-STKGATSIEKYDLRTNMWT 495
Query: 316 YLAEFPDHLGG---GYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
+A ++ G + + L + +YV GG DG + + V YN W+ + PM R
Sbjct: 496 PVA----NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHR 551
Query: 373 EYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLY 425
+VL+G +Y V ++ ER+D W + M+ P G+LY
Sbjct: 552 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 611
Query: 426 AIGSLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE--- 481
A+G G + ++C+DP T+ W+L C Q+ T NGL+Y + A
Sbjct: 612 AVGGRDGSSCLKSVECFDPHTNKWTL--CAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 669
Query: 482 --------VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAY 533
V+ Y+P + W + SM+ + +LG KLY GGYD L + VEAY
Sbjct: 670 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL-NTVEAY 728
Query: 534 DPETRAWSVVGRL 546
DP+T W+ V L
Sbjct: 729 DPQTNEWTQVAPL 741
Score = 56.2 bits (134), Expect = 8e-08
Identities = 42/134 (31%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 422 GRLYAIGSL-AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--RDD 478
G L+A+G + + K ++ YD T++W+ V F A L+ +Y V RD
Sbjct: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFG--VAVLDDKLYVVGGRDG 524
Query: 479 SAE---VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDP 535
V+ YNP W +P M+ G +AVL G +Y GG+D L+ VE +DP
Sbjct: 525 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLN-TVERWDP 583
Query: 536 ETRAWSVVGRLPEP 549
+ R W+ V + P
Sbjct: 584 QARQWNFVATMSTP 597
Score = 48.9 bits (115), Expect = 1e-05
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 12/94 (12%)
Query: 287 ILVLVGGCDQDCDELVT-----VDCYNPQTGQWRYLAEFP---DHLGGGYSIVALGNDIY 338
+L +GG D L + V+ Y+P+T W +A D +G + LG+ +Y
Sbjct: 656 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG----VCLLGDKLY 711
Query: 339 VTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
GG DG + V Y+ NEW +VAP+ R
Sbjct: 712 AVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 745
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 255 bits (652), Expect = 7e-68
Identities = 167/547 (30%), Positives = 263/547 (48%), Gaps = 25/547 (4%)
Query: 14 DPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESR 73
+PAH + +++LR+++ DV + A + AHR VLAA SPYF AMF G + ES+
Sbjct: 29 NPAHMGKAFKVMNELRSKQLLCDVMI-VAEDVEIEAHRVVLAACSPYFCAMFTGDMSESK 87
Query: 74 AERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQL 133
A+++ + V L L+D+ YT + V+ +N + LL AA LLQ V++ C FLQ QL
Sbjct: 88 AKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 147
Query: 134 DLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE--LGAEQLERLPLARLLRYLRDDGLC 191
NCL ++ FA+ +C+ L A + +H E LG E L L L ++ + D L
Sbjct: 148 HPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLS-LSLDQVCSLISSDKLT 206
Query: 192 VPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCL 251
V EE ++ + W+ + R H +L+E VRLP + R YL+ VE E L+ C
Sbjct: 207 VSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCK 266
Query: 252 RLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQT 311
L EA + D+ PR +PR L +++++VGG Q + +V+CY+ +
Sbjct: 267 DFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG--QAPKAIRSVECYDFEE 324
Query: 312 GQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKA 371
+W +AE P +V + +Y GG +GS V Y+ ++W +A M +
Sbjct: 325 DRWDQIAELPSRRCRA-GVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQER 383
Query: 372 REYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRL 424
R ++VL+ LLY V S E Y + T+ W + PM + G+L
Sbjct: 384 RSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKL 443
Query: 425 YAIGSLAGKETM---VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSA- 480
YA+G G ++ Y+P T+ W V + L+G +Y
Sbjct: 444 YAVGGYDGASRQCLSTVEQYNPATNEWIYV--ADMSTRRSGAGVGVLSGQLYATGGHDGP 501
Query: 481 ----EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPE 536
V+VY+P N W ++ MN + + G LYV GG D + L+ VE Y+P
Sbjct: 502 LVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLAS-VEYYNPV 560
Query: 537 TRAWSVV 543
T W+++
Sbjct: 561 TDKWTLL 567
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 252 bits (644), Expect = 6e-67
Identities = 172/534 (32%), Positives = 253/534 (47%), Gaps = 26/534 (4%)
Query: 25 LSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPP 84
+ ++R + K DVTL+ G F AHR VLAA+ PYF AMF + E + + + + G+ P
Sbjct: 28 MEEIRRQGKLCDVTLKI-GDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
Query: 85 DMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDF 144
L+ L++F+Y G +A+ N + LL A LQ ++K+AC FL+++L NCL ++ F
Sbjct: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
Query: 145 AEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLAL 203
AE C+ L AA FI +H E+ +E+ LPL +L + D L V EE ++ AL
Sbjct: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206
Query: 204 RWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAA 263
WVR D +R + P+LL +RLP R +L V+ + LV C C L+ EA+D+
Sbjct: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM 266
Query: 264 RYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQW---RYLAEF 320
+R P R RPR T +A ++ VGG + D L V+ ++P W R +
Sbjct: 267 P-ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTA 325
Query: 321 PDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVL 380
+G + + +Y GG DG V YN + W V M R + VL
Sbjct: 326 RSRVG----VAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
Query: 381 DGLLYVV-------AADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGK 433
DG +YV + S E Y TD W + M+ T GR+Y G G
Sbjct: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL 441
Query: 434 ETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--RDDS---AEVDVYNP 487
+ ++ Y+ T W G L A+L M+ D S + ++Y+
Sbjct: 442 QIFSSVEHYNHHTATWHPA-AGMLNK-RCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
Query: 488 TRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWS 541
++W I M+ SL G+LY GGYD LS VE YDPET W+
Sbjct: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSS-VEMYDPETDCWT 552
Score = 80.5 bits (197), Expect = 4e-15
Identities = 50/172 (29%), Positives = 77/172 (44%), Gaps = 10/172 (5%)
Query: 288 LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSR 347
+ + GG D + L +V+ Y+P+T +W + + V G IYV+GG DG +
Sbjct: 385 IYVCGGYDGN-SSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGR-IYVSGGHDGLQ 442
Query: 348 LYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTD 400
++ V YN W A ML R H ++ L ++V E Y D
Sbjct: 443 IFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVAD 502
Query: 401 SWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMV-MQCYDPDTDLWSLV 451
W + PM S A GRLYA+G G+ + ++ YDP+TD W+ +
Sbjct: 503 QWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFM 554
Score = 76.6 bits (187), Expect = 6e-14
Identities = 46/133 (34%), Positives = 65/133 (48%), Gaps = 10/133 (7%)
Query: 418 TACRGRLYAIGSL--AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV 475
T+ G +YA+G L AG V++ +DP + W C + A +NGL+Y +
Sbjct: 284 TSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWER--CRPMTTARSRVGVAVVNGLLYAI 341
Query: 476 RDDSAE-----VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVV 530
+ V+ YNP + W ++ SMN VL G++YV GGYD LS V
Sbjct: 342 GGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSV- 400
Query: 531 EAYDPETRAWSVV 543
E Y PET W+VV
Sbjct: 401 ETYSPETDKWTVV 413
Score = 57.4 bits (137), Expect = 4e-08
Identities = 36/98 (36%), Positives = 50/98 (51%), Gaps = 8/98 (8%)
Query: 456 LPPWSFAPKTAT-LNGLMYFVR------DDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLA 508
LP + P+ T + GL+Y V D V+V++P N W++ M +A
Sbjct: 273 LPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVA 332
Query: 509 VLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRL 546
V+ G LY GGYD LS VEAY+PET W+ VG +
Sbjct: 333 VVNGLLYAIGGYDGQLRLS-TVEAYNPETDTWTRVGSM 369
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/127 (28%), Positives = 50/127 (39%), Gaps = 8/127 (6%)
Query: 289 VLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRL 348
+ V G +V+ YN T W A + + +LG+ ++V GG DGS
Sbjct: 432 IYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCR-HGAASLGSKMFVCGGYDGSGF 490
Query: 349 YDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDS 401
Y+S ++W + PM R S G LY V S E YD TD
Sbjct: 491 LSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDC 550
Query: 402 WEALQPM 408
W + PM
Sbjct: 551 WTFMAPM 557
Score = 29.6 bits (65), Expect = 8.2
Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 288 LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGG 326
L VGG D + L +V+ Y+P+T W ++A H GG
Sbjct: 526 LYAVGGYDGQSN-LSSVEMYDPETDCWTFMAPMACHEGG 563
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 249 bits (636), Expect = 5e-66
Identities = 166/565 (29%), Positives = 259/565 (45%), Gaps = 38/565 (6%)
Query: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71
F D H + L + F D+TL+ G F HRAVLAA S YF+AMF ++E
Sbjct: 13 FKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKE 72
Query: 72 SRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
+++L G+ D+L+ L++++YT ++ ++ N + LL AADLLQF +VK+AC FL +
Sbjct: 73 KFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVR 132
Query: 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGL 190
LD+ NC+ M FAE C L ++R + E+ E+ + L + L L L
Sbjct: 133 HLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNL 192
Query: 191 CVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPC 250
V KEEA + ++W D R LL + +++ +P+ +
Sbjct: 193 SVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYI------------NIDIDPVYLKTALG 240
Query: 251 LRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQ 310
L+ + + + P + + ST + ++GG L V ++P
Sbjct: 241 LQRSCLLTENKIRSLIYNALNPMHKEISQRSTAT---MYIIGG--YYWHPLSEVHIWDPL 295
Query: 311 TGQWRYLAEFPDHLGGGYSIVALGNDIYVTGG--SDGSRLYDCVWRYNSSVNEWAEVAPM 368
T W AE PD+ Y + LG +IYVTGG +D D VW YNS +EW E PM
Sbjct: 296 TNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPM 355
Query: 369 LKAREYHSSSVLDGLLYVVA-------ADSTERYDHTTDSWEALQPMTYPMDNCSTTACR 421
L AR YH + L G +Y + A+ E YD + W + M + N +
Sbjct: 356 LNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLH 415
Query: 422 GRLYAIGSLAGKETMV----MQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRD 477
+Y IG G +Q Y+ D + WSL+ P + + +Y V
Sbjct: 416 DVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLC--SVPFENKLYLVGG 473
Query: 478 DSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYD---NTFELSDVVEAYD 534
+ + Y+P +NEW +I M + + ++ G +YV+GGY T+ S +E YD
Sbjct: 474 QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQS--IEKYD 531
Query: 535 PETRAWSVVGRLPEPTFWHGSVSIF 559
P+ W +VG LP HG V ++
Sbjct: 532 PDLNKWEIVGNLPSAMRSHGCVCVY 556
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 249 bits (635), Expect = 7e-66
Identities = 181/544 (33%), Positives = 258/544 (47%), Gaps = 25/544 (4%)
Query: 17 HALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER 76
HA S+L ++ LR DVTL +DFPAHR VLAA S YF AMF +L E
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQ-KDFPAHRIVLAACSDYFCAMFTSELSEKGKPY 73
Query: 77 VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
V + G+ +++LLDF YT V V+ +N + LL AA LLQ VK+AC FL+ QLD +
Sbjct: 74 VDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPS 133
Query: 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKE 195
NCL ++DFAE +C L AA+ F +H E + E+ L + + ++ D + V E
Sbjct: 134 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSE 193
Query: 196 EAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLR 255
E ++ + WV+ R P LL+ VR+P + Y+ ++AEP + C L+
Sbjct: 194 EPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVD 253
Query: 256 EARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWR 315
EA+ F R + + PR R R G E+L++VGG + V+ Y+P+T +W
Sbjct: 254 EAKKFH-LRPELRSQMQGPRTRAR--LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWS 310
Query: 316 YLAEFPDHLGGGYSIVALGNDIYVTGGSDG-SRL--YDCVWRYNSSVNEWAEVAPMLKAR 372
+L + V+L + IYV GG DG SRL +C+ W VAPM R
Sbjct: 311 FLPSI-TRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRR 369
Query: 373 EYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLY 425
++ L ++YV S ERYD D W L M + G +Y
Sbjct: 370 GLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIY 429
Query: 426 AIGSLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVR--DDSA-- 480
+G G + ++ YDP T W+ V + A LN +Y V D +A
Sbjct: 430 CLGGYDGLNILNSVEKYDPHTGHWTNVT--PMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
Query: 481 -EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRA 539
V+ YN + W + SM VL G+LY GYD LS +E YDP +
Sbjct: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSS-IECYDPIIDS 546
Query: 540 WSVV 543
W VV
Sbjct: 547 WEVV 550
Score = 33.9 bits (76), Expect = 0.44
Identities = 17/45 (37%), Positives = 25/45 (55%)
Query: 514 LYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
L V GG+ + DVVE YDP+T+ WS + + + SVS+
Sbjct: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSL 327
Score = 32.0 bits (71), Expect = 1.7
Identities = 28/114 (24%), Positives = 45/114 (39%), Gaps = 14/114 (12%)
Query: 264 RYDRHD---RGPCPRMRPRPSTGLAEI---LVLVGGCDQDCDELVTVDCYNPQTGQWRYL 317
+YD H P R G+A + + +VGG D L +V+ YN +T W +
Sbjct: 445 KYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA-HLSSVEAYNIRTDSWTTV 503
Query: 318 AEFPD---HLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPM 368
++G L +Y G DG+ L + Y+ ++ W V M
Sbjct: 504 TSMTTPRCYVGA----TVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 248 bits (632), Expect = 1e-65
Identities = 168/534 (31%), Positives = 254/534 (47%), Gaps = 35/534 (6%)
Query: 36 DVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY 95
D T E D + R VL++ S YF AMF +RE+R E +++ GV P+ L L+ ++Y
Sbjct: 159 DGTSEEENESDSSSCRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAY 218
Query: 96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLAS 155
TGR+ + DN E LL A LLQ V EAC FL +QL +NCL ++ FA+A C+ L
Sbjct: 219 TGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK 278
Query: 156 AAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
A + + H E + ++ LP + + + L D + +P EE L WVR D +R
Sbjct: 279 VAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRR 338
Query: 215 AHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCP 274
+LL +RLP + + LA +E L C +L+ EA + +R P
Sbjct: 339 KDLSKLLAYIRLPLLAPQF-LADMENNVLFRDDIECQKLIMEAMKYHLLP-ERRPMLQSP 396
Query: 275 RMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGG---GYSIV 331
R +PR ST L VGG D +++ Y+ +T W +A ++ G + +
Sbjct: 397 RTKPRKST--VGTLFAVGGMD-STKGATSIEKYDLRTNMWTPVA----NMNGRRLQFGVA 449
Query: 332 ALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-- 389
L + +YV GG DG + + V YN W+ + PM R +VL+G +Y V
Sbjct: 450 VLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD 509
Query: 390 -----DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETM-VMQCYDP 443
++ ER+D W + M+ P G+LYA+G G + ++C+DP
Sbjct: 510 GWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDP 569
Query: 444 DTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE-----------VDVYNPTRNEW 492
T+ W+L C Q+ T NGL+Y + A V+ Y+P + W
Sbjct: 570 HTNKWTL--CAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMW 627
Query: 493 DKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRL 546
+ SM+ + +LG KLY GGYD L + VEAYDP+T W+ V L
Sbjct: 628 TAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYL-NTVEAYDPQTNEWTQVAPL 680
Score = 56.2 bits (134), Expect = 8e-08
Identities = 42/134 (31%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 422 GRLYAIGSL-AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--RDD 478
G L+A+G + + K ++ YD T++W+ V F A L+ +Y V RD
Sbjct: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFG--VAVLDDKLYVVGGRDG 463
Query: 479 SAE---VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDP 535
V+ YNP W +P M+ G +AVL G +Y GG+D L+ VE +DP
Sbjct: 464 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLN-TVERWDP 522
Query: 536 ETRAWSVVGRLPEP 549
+ R W+ V + P
Sbjct: 523 QARQWNFVATMSTP 536
Score = 48.9 bits (115), Expect = 1e-05
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 12/94 (12%)
Query: 287 ILVLVGGCDQDCDELVT-----VDCYNPQTGQWRYLAEFP---DHLGGGYSIVALGNDIY 338
+L +GG D L + V+ Y+P+T W +A D +G + LG+ +Y
Sbjct: 595 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG----VCLLGDKLY 650
Query: 339 VTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
GG DG + V Y+ NEW +VAP+ R
Sbjct: 651 AVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 684
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 244 bits (624), Expect = 1e-64
Identities = 177/578 (30%), Positives = 269/578 (46%), Gaps = 30/578 (5%)
Query: 10 LPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQL 69
L F D + LLR L+ LR R DV++ AG R+ P HR VLA++SPYFRAMF
Sbjct: 9 LLFKDHDFSSDLLRQLNSLRQSRILTDVSI-CAGAREIPCHRNVLASSSPYFRAMFCSSF 67
Query: 70 RESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
RE +V+L G+ P L ++ + YTG ++ DN P++ AA +LQFP + EAC ++L
Sbjct: 68 REKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYL 127
Query: 130 QQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAE-QLERLPLARLLRYLRDD 188
Q QL +NCL M +E SC L A+ L E+ A L+ L L YL DD
Sbjct: 128 QSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDD 187
Query: 189 GLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCP 248
GLC +EE ++ + W++ D R + +L + VRL ++ + + + L+ P
Sbjct: 188 GLC-GEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSP 246
Query: 249 PCLRLLREARD--FQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDC 306
C +L A+ F D + PR S + L+L+GG V
Sbjct: 247 ACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNS--YQDFLILLGGRKDSQQTTRDVLL 304
Query: 307 YNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGG----SDGSRLYDCVWRYNSSVNEW 362
Y+ QTGQW+ LA+ P L S + L IYV GG S S + V+ ++ +N+W
Sbjct: 305 YSKQTGQWQSLAKLPTRLYKA-SAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQW 363
Query: 363 AEVAPMLKAREYHSSSVLDGLLYVVAA--------DSTERYDHTTDSWEALQPMTYPMDN 414
PML AR H S+ ++ + S ERYD + WE++ M + +
Sbjct: 364 RLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLH 423
Query: 415 CSTTACRGRLYAIG--SLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLM 472
+ RLY G + ++Q Y + W ++ + + L +
Sbjct: 424 PAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIK--NVCAPAVVLGERI 481
Query: 473 YFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGG----YDNTFELSD 528
V + + Y+P N++ K M + V+G KLYV+GG D E S
Sbjct: 482 VIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSA 541
Query: 529 VVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQT 566
+ YDPET W+ G+LP F H +++ Q +P+T
Sbjct: 542 SFDCYDPETDTWTSQGQLPHKLFDHACLTL--QCIPRT 577
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 240 bits (612), Expect = 3e-63
Identities = 174/565 (30%), Positives = 273/565 (48%), Gaps = 44/565 (7%)
Query: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71
F ++A S+L L+ LR +R F DV L A G R FP HRAVLAA S YF AMF+G L+E
Sbjct: 23 FHKSSYADSVLTHLNLLRQQRLFTDVLLHA-GNRTFPCHRAVLAACSRYFEAMFSGGLKE 81
Query: 72 SRAERVRL-HGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
S+ V + + P++L+LLLD++Y+ RV ++ +NAE LL A D+L+F +++AC FL+
Sbjct: 82 SQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLE 141
Query: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDG 189
+ L NCL M ++A C+ L + R L + + E +LP +++ L +
Sbjct: 142 KNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEE 201
Query: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPP 249
L E Y+ A+ W+ D +R + P+LL+ VRL + YL+ +V E L+ +
Sbjct: 202 LETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRK 261
Query: 250 CLRLLREA--RDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCY 307
++ EA + + D C R R TG A L L+GG CD+L VD
Sbjct: 262 SKEIVEEAIRCKLKILQNDGVVTSLCARPR---KTGHA--LFLLGGQTFMCDKLYLVD-- 314
Query: 308 NPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSR-LYDCVWRYNSSVNEWAEVA 366
+ + A+ P +S A+G +Y+TGG + VW Y++ EW++ A
Sbjct: 315 -QKAKEIIPKADIPSP-RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAA 372
Query: 367 PMLKAREYHSSSVLDGLLYVVAADS----------------TERYDHTTDSWEALQPMTY 410
PML AR H S+ L LYVV + E YD T + W + P+
Sbjct: 373 PMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLRE 432
Query: 411 PMDNCSTTACRGRLYAIG--SLAGKETMVMQCYDPDTDLWSL-VDCGQLPPWSFAPKTAT 467
+ N + + + +L+A G S++ + +QCYD + W++ C Q PW + A
Sbjct: 433 GVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ--PWRYT--AAA 488
Query: 468 LNGLMYFVRDDSAEVDV-----YNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDN 522
+ G F+ E +N +W K+ + + G KLYV GGY
Sbjct: 489 VLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFG 548
Query: 523 TFELSDVVEAYDPETRAWSVVGRLP 547
+ ++ YDP W+ + +P
Sbjct: 549 -IQRCKTLDCYDPTLDVWNSITTVP 572
Score = 44.3 bits (103), Expect = 3e-04
Identities = 35/134 (26%), Positives = 55/134 (41%), Gaps = 13/134 (9%)
Query: 288 LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVA-LGNDIYVTGGSDGS 346
L GG D+L V CY+ +W A P Y+ A LGN I++ GG +
Sbjct: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWR--YTAAAVLGNQIFIMGGD--T 501
Query: 347 RLYDC-VWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-------DSTERYDHT 398
C +++NS +W +V + R + LYVV + + YD T
Sbjct: 502 EFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPT 561
Query: 399 TDSWEALQPMTYPM 412
D W ++ + Y +
Sbjct: 562 LDVWNSITTVPYSL 575
Score = 35.4 bits (80), Expect = 0.15
Identities = 17/69 (24%), Positives = 32/69 (46%)
Query: 481 EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW 540
+V+ Y+PT N+W + + + ++ KL+ GG + + V+ YD W
Sbjct: 413 QVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRW 472
Query: 541 SVVGRLPEP 549
+V P+P
Sbjct: 473 TVPATCPQP 481
Score = 30.4 bits (67), Expect = 4.8
Identities = 16/53 (30%), Positives = 24/53 (45%)
Query: 506 SLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
S +G K+Y++GG + +S V YD WS + F HGS +
Sbjct: 334 SACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAEL 386
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 239 bits (611), Expect = 4e-63
Identities = 177/563 (31%), Positives = 268/563 (47%), Gaps = 40/563 (7%)
Query: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71
F +H +L L+ LR F DVTL A G R FP HRAVLAA+S YF AMF+ LRE
Sbjct: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWA-GDRAFPCHRAVLAASSRYFEAMFSHGLRE 81
Query: 72 SRAERVRLH-GVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
SR + V + P++L+LLLDF+Y+ R+A++ +NAE LL A D+LQF V++A FL+
Sbjct: 82 SRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Query: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDG 189
+ L +NCL M ++A C L + R L H + +E L LL + D
Sbjct: 142 KNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDE 201
Query: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPP 249
L E ++ L+WV+ D R H P+LL +VRL + L V +E L+
Sbjct: 202 LETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADER 261
Query: 250 CLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNP 309
++ EA + P RPR + L+++GG CD++ VD
Sbjct: 262 TKLIMDEALRCKTRILQNDGVVTSPCARPRKA---GHTLLILGGQTFMCDKIYQVD---H 315
Query: 310 QTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSR-LYDCVWRYNSSVNEWAEVAPM 368
+ + A+ P +S A+G +YVTGG + VW Y++ EW++ APM
Sbjct: 316 KAKEIIPKADLPSP-RKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPM 374
Query: 369 LKAREYHSSSVLDGLLYVVAADST----------------ERYDHTTDSWEALQPMTYPM 412
L AR H S+ L+ LYVV ++ E+YD + W + P+ +
Sbjct: 375 LIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGV 434
Query: 413 DNCSTTACRGRLYAIGSLAGKETMV--MQCYDPDTDLWSL-VDCGQLPPWSFAPKTATLN 469
N + + + +L+ G + MV +QCYDP + W++ +C Q PW + A +
Sbjct: 435 SNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQ--PWRYT--AAAVL 490
Query: 470 GLMYFVRDDSAEVDVYNPTR-----NEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTF 524
G F+ E + R N+W +I M + G KLYV GGY T
Sbjct: 491 GSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGT- 549
Query: 525 ELSDVVEAYDPETRAWSVVGRLP 547
+ ++ YDP + W+ + +P
Sbjct: 550 QRCKTLDCYDPTSDTWNCITTVP 572
Score = 50.4 bits (119), Expect = 5e-06
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 11/133 (8%)
Query: 288 LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVA-LGNDIYVTGGSDGS 346
L + GG D + V CY+P +W AE P Y+ A LG+ I++ GG D
Sbjct: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWR--YTAAAVLGSQIFIMGG-DTE 502
Query: 347 RLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAAD-STER------YDHTT 399
+R++ N+W + M R + LYVV T+R YD T+
Sbjct: 503 FTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTS 562
Query: 400 DSWEALQPMTYPM 412
D+W + + Y +
Sbjct: 563 DTWNCITTVPYSL 575
Score = 31.2 bits (69), Expect = 2.8
Identities = 17/53 (32%), Positives = 25/53 (47%)
Query: 506 SLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
S + +G K+YV+GG + +S V YD WS + F HGS +
Sbjct: 334 SASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAEL 386
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 235 bits (600), Expect = 8e-62
Identities = 167/544 (30%), Positives = 250/544 (45%), Gaps = 30/544 (5%)
Query: 17 HALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER 76
HA LR + E++ DV L AG PAHR VL+A S YF AMF + E++ E
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLL-IAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 77 VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
VR+ GV P+ L L+ ++YTG + + D E LL AA LLQ V + C FL +QL +
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKE 195
NCL ++ F +A C+ L + A ++ + H E + ++ LP + + L D + VP E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 196 EAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLR 255
E + ++WV D R LL +RLP + LLA +E + C +LL
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPP-QLLADLETSSMFTGDLECQKLLM 401
Query: 256 EARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWR 315
EA + +R PR +PR ST L VGG D T++ Y+ +T W
Sbjct: 402 EAMKYHLLP-ERRSMMQSPRTKPRKST--VGALYAVGGMDA-MKGTTTIEKYDLRTNSWL 457
Query: 316 YLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYH 375
++ + + + + N +YV GG DG + + V +N W + PM R
Sbjct: 458 HIGTM-NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGL 516
Query: 376 SSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIG 428
+ L+G +Y V ++ ER+D W + M+ P A +LYAIG
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIG 576
Query: 429 SLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE------ 481
G + M+ +DP T+ WSL C + AT NG +Y V A
Sbjct: 577 GRDGSSCLKSMEYFDPHTNKWSL--CAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCS 634
Query: 482 -----VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPE 536
V+ Y+P + W + ++ ++ LG KLYV GGYD L + VE+YD +
Sbjct: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL-NTVESYDAQ 693
Query: 537 TRAW 540
W
Sbjct: 694 RNEW 697
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/143 (30%), Positives = 67/143 (46%), Gaps = 9/143 (6%)
Query: 422 GRLYAIGSL-AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--RDD 478
G LYA+G + A K T ++ YD T+ W + G + A ++ +Y V RD
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSW--LHIGTMNGRRLQFGVAVIDNKLYVVGGRDG 486
Query: 479 SAE---VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDP 535
V+ +NP W +P M+ G +A L G +Y GG+D L+ VE +DP
Sbjct: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLN-TVERWDP 545
Query: 536 ETRAWSVVGRLPEPTFWHGSVSI 558
E R W+ V + P G V++
Sbjct: 546 EGRQWNYVASMSTPRSTVGVVAL 568
Score = 39.7 bits (91), Expect = 0.008
Identities = 33/118 (27%), Positives = 50/118 (42%), Gaps = 9/118 (7%)
Query: 274 PRMRPRPSTGLAE---ILVLVGGCD----QDCDELVT-VDCYNPQTGQWRYLAEFPDHLG 325
P + R G+A L +VGG D C L V+ Y+P+ W +A
Sbjct: 602 PMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRD 661
Query: 326 GGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGL 383
++ LG+ +YV GG DG + V Y++ NEW E L Y + + + L
Sbjct: 662 A-VAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKESMQELLQNFYTTQKLKETL 718
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 235 bits (600), Expect = 8e-62
Identities = 167/544 (30%), Positives = 250/544 (45%), Gaps = 30/544 (5%)
Query: 17 HALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER 76
HA LR + E++ DV L AG PAHR VL+A S YF AMF + E++ E
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLL-IAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 77 VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
VR+ GV P+ L L+ ++YTG + + D E LL AA LLQ V + C FL +QL +
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKE 195
NCL ++ F +A C+ L + A ++ + H E + ++ LP + + L D + VP E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 196 EAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLR 255
E + ++WV D R LL +RLP + LLA +E + C +LL
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPP-QLLADLETSSMFTGDLECQKLLM 401
Query: 256 EARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWR 315
EA + +R PR +PR ST L VGG D T++ Y+ +T W
Sbjct: 402 EAMKYHLLP-ERRSMMQSPRTKPRKST--VGALYAVGGMDA-MKGTTTIEKYDLRTNSWL 457
Query: 316 YLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYH 375
++ + + + + N +YV GG DG + + V +N W + PM R
Sbjct: 458 HIGTM-NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGL 516
Query: 376 SSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIG 428
+ L+G +Y V ++ ER+D W + M+ P A +LYAIG
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIG 576
Query: 429 SLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE------ 481
G + M+ +DP T+ WSL C + AT NG +Y V A
Sbjct: 577 GRDGSSCLKSMEYFDPHTNKWSL--CAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCS 634
Query: 482 -----VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPE 536
V+ Y+P + W + ++ ++ LG KLYV GGYD L + VE+YD +
Sbjct: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYL-NTVESYDAQ 693
Query: 537 TRAW 540
W
Sbjct: 694 RNEW 697
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/143 (30%), Positives = 67/143 (46%), Gaps = 9/143 (6%)
Query: 422 GRLYAIGSL-AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--RDD 478
G LYA+G + A K T ++ YD T+ W + G + A ++ +Y V RD
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSW--LHIGTMNGRRLQFGVAVIDNKLYVVGGRDG 486
Query: 479 SAE---VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDP 535
V+ +NP W +P M+ G +A L G +Y GG+D L+ VE +DP
Sbjct: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLN-TVERWDP 545
Query: 536 ETRAWSVVGRLPEPTFWHGSVSI 558
E R W+ V + P G V++
Sbjct: 546 EGRQWNYVASMSTPRSTVGVVAL 568
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 9/103 (8%)
Query: 274 PRMRPRPSTGLAE---ILVLVGGCD----QDCDELVT-VDCYNPQTGQWRYLAEFPDHLG 325
P + R G+A L +VGG D C L V+ Y+P+ W +A
Sbjct: 602 PMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRD 661
Query: 326 GGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPM 368
++ LG+ +YV GG DG + V Y++ NEW E P+
Sbjct: 662 A-VAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPV 703
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 229 bits (584), Expect = 5e-60
Identities = 160/550 (29%), Positives = 254/550 (46%), Gaps = 30/550 (5%)
Query: 17 HALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAER 76
HA R + +++ DV L G R PAHR VL++ S YF AMF + E++ E
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVIL-IVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEE 252
Query: 77 VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLA 136
+++ G+ P+ L L+ F+YTG + + D E LL AA LLQ P V E C FL + L +
Sbjct: 253 IKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPS 312
Query: 137 NCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKE 195
NCL ++ FA+A C L A + + ++ E + ++ LP L + L D + VP E
Sbjct: 313 NCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDE 372
Query: 196 EAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLR 255
E + + WV+ D R LL +RLP + +LA +E L C +L+
Sbjct: 373 ETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPP-QILADLENHALFKNDLECQKLIL 431
Query: 256 EARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWR 315
EA + +R PR +PR ST L VGG D + T++ Y+ +T W
Sbjct: 432 EAMKYHLLP-ERRTLMQSPRTKPRKST--VGTLYAVGGMDNN-KGATTIEKYDLRTNLW- 486
Query: 316 YLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYH 375
A + + + + + ++V GG DG + + V YN W + PM R
Sbjct: 487 IQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGL 546
Query: 376 SSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIG 428
+VL+G +Y V ++ ER+D + W + M+ A G+LY++G
Sbjct: 547 GVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVG 606
Query: 429 SLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE------ 481
G + M+ YDP T+ W++ C + AT +G +Y V A
Sbjct: 607 GRDGSSCLSSMEYYDPHTNKWNM--CAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCS 664
Query: 482 -----VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPE 536
V+ Y+P + W + ++ + +LG +LY GGYD L + +E+YDP+
Sbjct: 665 RLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYL-NTMESYDPQ 723
Query: 537 TRAWSVVGRL 546
T W+ + L
Sbjct: 724 TNEWTQMASL 733
>gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 702
Score = 223 bits (568), Expect = 4e-58
Identities = 137/387 (35%), Positives = 210/387 (54%), Gaps = 15/387 (3%)
Query: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMF------ 65
F+DP H +L+ L+Q R + F D+ + GR+F H+ VLA+ S YF+ +
Sbjct: 306 FTDPGHPREMLKELNQQRRAKAFTDLKI-VVEGREFEVHQNVLASCSLYFKDLIQRSVQD 364
Query: 66 AGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125
+GQ + E V L + D+L+LLL+F YTG + + NA+ LL AA QF + C
Sbjct: 365 SGQGGREKLELV-LSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
Query: 126 GAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR--LLR 183
+FL++QL +NCL + AEA CS L A+ F L+ E+ A++ E L +++ +
Sbjct: 424 VSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQE-EILSISKDDFIA 482
Query: 184 YLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPL 243
Y+ +D L EE Y+ ++W++ DP R + +LL VRLPF+ YLL V+ E L
Sbjct: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Query: 244 VARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGG---CDQDCDE 300
+ C L+ EA+ + + R + PR RPR S G+AE++VLVGG
Sbjct: 543 IKSSEACRDLVNEAKRYHMLPHARQEM-QTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS 601
Query: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360
LV V C+NPQ +W LA P + +S+V+ G++IY++GG + VW Y S ++
Sbjct: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
Query: 361 EWAEVAPMLKAREYHSSSVLDGLLYVV 387
W V+ M R H+S V DG +Y +
Sbjct: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTL 688
Score = 32.3 bits (72), Expect = 1.3
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 2/76 (2%)
Query: 482 VDVYNPTRNEWDKIPSMNQV-HVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW 540
V +NP N+W + S+ S+ G +Y+SGG ++ L+D V Y W
Sbjct: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLAD-VWCYMSLLDNW 663
Query: 541 SVVGRLPEPTFWHGSV 556
++V R+ P H S+
Sbjct: 664 NLVSRMTVPRCRHNSL 679
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 219 bits (559), Expect = 4e-57
Identities = 147/491 (29%), Positives = 234/491 (47%), Gaps = 22/491 (4%)
Query: 69 LRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAF 128
+ ESRA+RVR+ V L++L+D+ YT + V+ +N + LL AA LLQ VK+ C F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 129 LQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRD 187
L+ QL NCL ++ FA+ +C+ L + A + +H ++ +E+ L + ++ +
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 188 DGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARC 247
D L + EE ++ + WV D R +L+E VRLP + R YL+ VE E LV
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 248 PPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCY 307
C L EA + ++ R R R L +++V+VGG Q + +V+CY
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECY 238
Query: 308 NPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAP 367
+ + +W +AE P +V + ++ GG +GS V Y+ ++W VA
Sbjct: 239 DFKEERWHQVAELPSRRCRA-GMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVAN 297
Query: 368 MLKAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTAC 420
M R ++VL+GLLY V S E Y+ ++ W + PM +
Sbjct: 298 MRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVV 357
Query: 421 RGRLYAIGSLAGKETM---VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRD 477
G LYA+G G ++CY+ T+ W+ + ++ LN L+Y V
Sbjct: 358 GGLLYAVGGYDGASRQCLSTVECYNATTNEWTYI--AEMSTRRSGAGVGVLNNLLYAVGG 415
Query: 478 DSA-----EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEA 532
V+VY+PT N W ++ MN + + G LYV GG D + L+ VE
Sbjct: 416 HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLAS-VEY 474
Query: 533 YDPETRAWSVV 543
Y+P T W+VV
Sbjct: 475 YNPTTDKWTVV 485
Score = 43.9 bits (102), Expect = 4e-04
Identities = 31/99 (31%), Positives = 47/99 (47%), Gaps = 3/99 (3%)
Query: 284 LAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGS 343
L +L VGG D +V+ Y+P T WR +A+ + + A+ +YV GG
Sbjct: 406 LNNLLYAVGGHDGPLVRK-SVEVYDPTTNAWRQVADM-NMCRRNAGVCAVNGLLYVVGGD 463
Query: 344 DGSRLYDCVWRYNSSVNEWAEVAP-MLKAREYHSSSVLD 381
DGS V YN + ++W V+ M R Y +V+D
Sbjct: 464 DGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVID 502
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 213 bits (542), Expect = 4e-55
Identities = 157/567 (27%), Positives = 255/567 (44%), Gaps = 38/567 (6%)
Query: 11 PFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLR 70
PFS HA +L ++++R + F DV L+ G F AHR VLAA+SPYF A+F G ++
Sbjct: 13 PFSSDKHAQLILAQINKMRNGQHFCDVQLQV-GQESFKAHRLVLAASSPYFAALFTGGMK 71
Query: 71 ESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
ES + V + G+ + Q+LLDF YTG V + +N + L+ AAD+LQ V C FL+
Sbjct: 72 ESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLK 131
Query: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDG 189
Q+D NC+ + F+E +C L ++ +I H E+ E+ L +L++ LR +
Sbjct: 132 GQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEE 191
Query: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPP 249
L + E + A++W+ D +R H ++L+ +R P + LL ++E
Sbjct: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVA 251
Query: 250 CLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQ-------DCDELV 302
LL+E + + + + RP + L VGG + D L
Sbjct: 252 LQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALS 311
Query: 303 TVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEW 362
V+ ++ + W ++ G + LG +Y GG S ++DC Y+ +W
Sbjct: 312 CVERFDTFSQYWTTVSSL-HQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQW 370
Query: 363 AEVAPMLKAREYHSSSVLDGLLYVVA-------ADSTERYDHTTDSWEALQPMTYPMDNC 415
VA M R V G +Y + ++ ER+D + WE + M
Sbjct: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
Query: 416 STTACRGRLYAIGSLA--GKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPK---TATLNG 470
+G +Y IG ++ G E + YDP + WS LPP A LN
Sbjct: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWS-----PLPPMGTRRAYLGVAALND 485
Query: 471 LMYFV------RDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTF 524
+Y V +D V+ Y+ +W ++ SM G + + G LYVSGG ++
Sbjct: 486 CIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSH 545
Query: 525 EL-----SDVVEAYDPETRAWSVVGRL 546
+ D VE Y+P + W+ +G +
Sbjct: 546 DFLAPGTLDSVEVYNPHSDTWTEIGNM 572
Score = 75.1 bits (183), Expect = 2e-13
Identities = 62/250 (24%), Positives = 103/250 (41%), Gaps = 25/250 (10%)
Query: 282 TGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTG 341
T L ++ +GG ++D +CY+P T QW +A +H G + IY G
Sbjct: 339 TVLGGMVYAIGG-EKDSMIFDCTECYDPVTKQWTTVASM-NHPRCGLGVCVCYGAIYALG 396
Query: 342 GSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAADSTER------- 394
G G+ + + + R++ N+W V M +R Y + GL+YV+ S E
Sbjct: 397 GWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFE 456
Query: 395 -YDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMV--MQCYDPDTDLWSLV 451
YD + W L PM A +Y++G + + ++ Y + + W V
Sbjct: 457 VYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEV 516
Query: 452 DCGQLPPWSFAPKTATLNGLMYFVRDDSAE-----------VDVYNPTRNEWDKIPSMNQ 500
++P +NGL+Y S+ V+VYNP + W +I +M
Sbjct: 517 ASMKVPRAGMC--VVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMIT 574
Query: 501 VHVGGSLAVL 510
G +AVL
Sbjct: 575 SRCEGGVAVL 584
Score = 53.1 bits (126), Expect = 7e-07
Identities = 35/167 (20%), Positives = 58/167 (34%), Gaps = 44/167 (26%)
Query: 388 AADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDL 447
A ER+D + W + + T G +YAIG K++M+ C
Sbjct: 309 ALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGG--EKDSMIFDC------- 359
Query: 448 WSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSL 507
+ Y+P +W + SMN G +
Sbjct: 360 ----------------------------------TECYDPVTKQWTTVASMNHPRCGLGV 385
Query: 508 AVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHG 554
V G +Y GG+ E+ + +E +DP+ W VVG + ++ G
Sbjct: 386 CVCYGAIYALGGWVGA-EIGNTIERFDPDENKWEVVGNMAVSRYYFG 431
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 211 bits (537), Expect = 2e-54
Identities = 163/569 (28%), Positives = 260/569 (45%), Gaps = 45/569 (7%)
Query: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRD-FPAHRAVLAAASPYFRAMFAGQLR 70
F+ H+ +L+G QLR E DVTL G + FP HRA++A+AS YF+AMF G ++
Sbjct: 27 FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMK 86
Query: 71 ESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
E ++LHGV L+ ++DF YT +++++ DN + L AA LQ V + C FL
Sbjct: 87 EQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 146
Query: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHV-GELGAEQLERLPLARLLRYLRDDG 189
+ L NC+++ A ++ + FIL++ L + +LP RL L +
Sbjct: 147 SGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNS 206
Query: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPP 249
L E ++ A RW+R + P R + +L++ +R P + L+ +V+ +
Sbjct: 207 LKHCTELELFKAACRWLRLEDP-RMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNT 265
Query: 250 CLRLLREARDFQAARYDRHDRGPCPRM---RPRPSTGLAEILVLVGGCDQDCDELVTVDC 306
C+ LL EA ++Q Y + P M R + ++ L G Q +
Sbjct: 266 CVNLLLEASNYQMMPYMQ------PVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRM 319
Query: 307 YNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGG-----SDGSRLYDCVWRYNSSVNE 361
Y+ + +WR LA D + I +GN +YV GG + G D V+R++ N+
Sbjct: 320 YDERAQEWRSLAPM-DAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 378
Query: 362 WAEVAPMLKAREYHSSSVLDGLLYVVAADS-------TERYDHTTDSWEALQPMTYPMDN 414
W +VA + + R + S L G LY V S E Y+ + W + M+ P
Sbjct: 379 WMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYG 438
Query: 415 CSTTACRGRLYAIGSLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPK---TATLNG 470
+ T G +Y G + + C+DPDTD W Q P + T+
Sbjct: 439 HAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWM-----QKAPMTTVRGLHCMCTVGD 493
Query: 471 LMYFV----------RDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGY 520
+Y + DD + Y+PT ++W I +M + +AV K+YV GGY
Sbjct: 494 KLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 553
Query: 521 D-NTFELSDVVEAYDPETRAWSVVGRLPE 548
N + ++V+ YDPE W V LPE
Sbjct: 554 SWNNRCMVEIVQKYDPEKDEWHKVFDLPE 582
Score = 52.4 bits (124), Expect = 1e-06
Identities = 42/165 (25%), Positives = 68/165 (41%), Gaps = 19/165 (11%)
Query: 405 LQPMTYPMDNCSTTACRG---RLYAIGSLAGKETMV---MQCYDPDTDLWSLVDCGQLPP 458
+ P P+ TA R L +G + ++ +V ++ YD W + P
Sbjct: 278 MMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPR 337
Query: 459 WSFAPKTATLNGLMYFVRDDS-------AEVDV---YNPTRNEWDKIPSMNQVHVGGSLA 508
+ A + +Y V S VD ++P N+W ++ S+N+ L+
Sbjct: 338 YQHG--IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLS 395
Query: 509 VLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWH 553
L G LY GG EL+ VE Y+P WS V ++ EP + H
Sbjct: 396 ALKGHLYAVGGRSAAGELA-TVECYNPRMNEWSYVAKMSEPHYGH 439
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 208 bits (530), Expect = 1e-53
Identities = 143/526 (27%), Positives = 245/526 (46%), Gaps = 25/526 (4%)
Query: 36 DVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY 95
DVTL+ G + H+ VLA PYFRAMF ++ E++ + + D ++ L+ F Y
Sbjct: 68 DVTLKV-GSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVY 126
Query: 96 TGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLAS 155
+ R+ ++ DN +PLL AA +LQ V AC +++ +NCL ++ FAE+ + L
Sbjct: 127 SSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMD 186
Query: 156 AAQRFILRHVGE-LGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214
A ++ H E + E + L + L L + E+ Y A++W+ A+P +
Sbjct: 187 MADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHS 246
Query: 215 AHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCP 274
+ L VRLP + +L+ V E +V + C LL EAR++ R
Sbjct: 247 KWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEY 306
Query: 275 RMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPD---HLGGGYSIV 331
+R P A +L VGG D +++CY+ W + E H+G ++
Sbjct: 307 SIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG----VI 362
Query: 332 ALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA-- 389
++ +Y GG DG+ + ++ N+W A M R + + L G +Y +
Sbjct: 363 SVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLD 422
Query: 390 -----DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETM-VMQCYDP 443
+ ERYD +D W + PM P + A +YA+G G ++ ++ YDP
Sbjct: 423 DNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDP 482
Query: 444 DTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVR--DDS---AEVDVYNPTRNEWDKIPSM 498
D W ++ ++ + L+G +Y V DD+ + V+ Y+P N+WD + ++
Sbjct: 483 HLDKW--IEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL 540
Query: 499 NQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVG 544
G +A + GK++ GG++ L + VEA+DP W +VG
Sbjct: 541 TTPRGGVGIATVMGKIFAVGGHNGNAYL-NTVEAFDPVLNRWELVG 585
Score = 52.0 bits (123), Expect = 2e-06
Identities = 35/114 (30%), Positives = 54/114 (47%), Gaps = 15/114 (13%)
Query: 459 WSFAPK---------TATLNGLMYFV-----RDDSAEVDVYNPTRNEWDKIPSMNQVHVG 504
W F P+ ++ G +Y V + +++++P N+W SMN G
Sbjct: 346 WFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRG 405
Query: 505 GSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSI 558
+LA LGG +Y GG D+ +DV E YD E+ WS V + P GSV++
Sbjct: 406 IALASLGGPIYAIGGLDDNTCFNDV-ERYDIESDQWSTVAPMNTPRGGVGSVAL 458
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/97 (27%), Positives = 48/97 (49%), Gaps = 5/97 (5%)
Query: 279 RPSTGLAEI---LVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGN 335
R G++++ L +VGG D D L +V+ Y+P++ +W Y+A GG I +
Sbjct: 497 RAGNGVSKLHGCLYVVGGFD-DNSPLSSVERYDPRSNKWDYVAALTTPRGG-VGIATVMG 554
Query: 336 DIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAR 372
I+ GG +G+ + V ++ +N W V + R
Sbjct: 555 KIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCR 591
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 208 bits (529), Expect = 1e-53
Identities = 168/565 (29%), Positives = 260/565 (46%), Gaps = 36/565 (6%)
Query: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71
FS P+H+ SLL+GL+ LRA+ + LDV L FPAH+ VLAA S YFRAMF G +RE
Sbjct: 40 FSAPSHSTSLLQGLATLRAQGQLLDVVL-TINREAFPAHKVVLAACSDYFRAMFTGGMRE 98
Query: 72 SRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
+ + + L GV L+ ++DF+Y+ V + D + +L AA LQ V E C FL+
Sbjct: 99 ASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKA 158
Query: 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQ-LERLPLARLLRYLRDDGL 190
+ + CL++ A FS + L + F RH ++ E+ RLPL RL+ +L+ + L
Sbjct: 159 AMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRL 218
Query: 191 CVPKEEAAYQLALRWVRADPPR--RAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCP 248
E ++ A+RW++ DP R RA+H +L +R P ++ L+ V+ ++
Sbjct: 219 QSCAEIDLFRAAVRWLQHDPARRPRASH---VLCHIRFPLMQSSELVDSVQTLDIMVEDV 275
Query: 249 PCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCD-QDCDELVTVDCY 307
C + L EA ++Q + +H+ PR R LV GG D D V+ Y
Sbjct: 276 LCRQYLLEAFNYQVLPFRQHEM-QSPRTAVRSD---VPSLVTFGGTPYTDSDRSVSSKVY 331
Query: 308 N-PQTGQWRYLAEFPDHLGGGYSIVA-LGNDIYVTGGS-----DGSRLYDCVWRYNSSVN 360
P+ G + +G ++ VA L N +YV GG G D +RY+ +N
Sbjct: 332 QLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLN 391
Query: 361 EWAEVAPMLKAREYHSSSVLDGLLYVV-------AADSTERYDHTTDSWEALQPMTYPMD 413
W + M ++R +VL G++Y + S ERY + W +
Sbjct: 392 RWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTW 451
Query: 414 NCSTTACRGRLYAIG--SLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTA----- 466
+ A GRLY G ++ ++ + CYDP D W P A A
Sbjct: 452 GHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIY 511
Query: 467 TLNGLMYFVRD--DSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYD-NT 523
L G M V D V+ Y P ++W + M +L K+Y+ GGY+
Sbjct: 512 ALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRL 571
Query: 524 FELSDVVEAYDPETRAWSVVGRLPE 548
++ +V+ Y+ +T W PE
Sbjct: 572 NNVTGIVQVYNTDTDEWERDLHFPE 596
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 207 bits (527), Expect = 2e-53
Identities = 151/554 (27%), Positives = 241/554 (43%), Gaps = 59/554 (10%)
Query: 11 PFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLR 70
PFS HA +L ++++R + F DV L+ G F AHR VLAA+SPYF A+F G ++
Sbjct: 13 PFSSDKHAQLILAQINKMRNGQHFCDVQLQV-GQESFKAHRLVLAASSPYFAALFTGGMK 71
Query: 71 ESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
ES + V + G+ + Q+LLDF YTG V + +N + L+ AAD+LQ V C FL+
Sbjct: 72 ESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLK 131
Query: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDG 189
Q+D NC+ + F+E +C L ++ +I H E+ E+ L +L++ LR +
Sbjct: 132 GQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEE 191
Query: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPP 249
L + E + A++W+ D +R H ++L+ +R P + LL ++E
Sbjct: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVA 251
Query: 250 CLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNP 309
LL+E + + + + RP + L VGG +
Sbjct: 252 LQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTR------------L 299
Query: 310 QTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPML 369
Q G+W SR CV R+++ W V+ +
Sbjct: 300 QGGRW-----------------------------SDSRALSCVERFDTFSQYWTTVSSLH 330
Query: 370 KAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRG 422
+AR +VL G++Y + D TE YD T W + M +P C G
Sbjct: 331 QARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYG 390
Query: 423 RLYAIGSLAGKET-MVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE 481
+YA+G G E ++ +DPD + W +V + + F + GL+Y + S E
Sbjct: 391 AIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFG--CCEMQGLIYVIGGISNE 448
Query: 482 ------VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDP 535
+VY+P W +P M +A L +Y GG++ T + VE Y
Sbjct: 449 GIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
Query: 536 ETRAWSVVGRLPEP 549
E W V + P
Sbjct: 509 EEEKWVEVASMKVP 522
Score = 53.1 bits (126), Expect = 7e-07
Identities = 35/167 (20%), Positives = 58/167 (34%), Gaps = 44/167 (26%)
Query: 388 AADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDL 447
A ER+D + W + + T G +YAIG K++M+ C
Sbjct: 309 ALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGG--EKDSMIFDC------- 359
Query: 448 WSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSL 507
+ Y+P +W + SMN G +
Sbjct: 360 ----------------------------------TECYDPVTKQWTTVASMNHPRCGLGV 385
Query: 508 AVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHG 554
V G +Y GG+ E+ + +E +DP+ W VVG + ++ G
Sbjct: 386 CVCYGAIYALGGWVGA-EIGNTIERFDPDENKWEVVGNMAVSRYYFG 431
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,313,982
Number of Sequences: 37866
Number of extensions: 1198771
Number of successful extensions: 4056
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 161
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 2553
Number of HSP's gapped (non-prelim): 393
length of query: 597
length of database: 18,247,518
effective HSP length: 108
effective length of query: 489
effective length of database: 14,157,990
effective search space: 6923257110
effective search space used: 6923257110
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.