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Search of human proteins with 5453918
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453918 solute carrier family 25 (mitochondrial carrier;
peroxisomal membrane protein, 34kDa), member 17 [Homo sapiens]
(307 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453918 solute carrier family 25 (mitochondrial carrier; pero... 604 e-173
gi|21314739 solute carrier family 25, member 32 [Homo sapiens] 110 1e-24
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 86 3e-17
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 86 3e-17
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 86 3e-17
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 84 2e-16
gi|157388989 solute carrier family 25, member 36 isoform a [Homo... 83 3e-16
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 83 3e-16
gi|157388991 solute carrier family 25, member 36 isoform b [Homo... 80 2e-15
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 79 5e-15
gi|13259541 uncoupling protein 2 [Homo sapiens] 79 7e-15
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 78 9e-15
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 78 9e-15
gi|82775373 solute carrier family 25, member 37 [Homo sapiens] 76 4e-14
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 75 6e-14
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 75 6e-14
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 75 6e-14
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 75 6e-14
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 75 6e-14
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 75 6e-14
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 75 6e-14
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 75 6e-14
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 75 1e-13
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 75 1e-13
gi|149274643 solute carrier family 25, member 28 [Homo sapiens] 74 2e-13
gi|60460887 solute carrier family 25, member 42 [Homo sapiens] 73 4e-13
gi|149274607 solute carrier family 25, member 41 [Homo sapiens] 72 6e-13
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 72 8e-13
gi|11225256 uncoupling protein 1 [Homo sapiens] 70 2e-12
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 70 2e-12
>gi|5453918 solute carrier family 25 (mitochondrial carrier;
peroxisomal membrane protein, 34kDa), member 17 [Homo
sapiens]
Length = 307
Score = 604 bits (1557), Expect = e-173
Identities = 307/307 (100%), Positives = 307/307 (100%)
Query: 1 MASVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEG 60
MASVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEG
Sbjct: 1 MASVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEG 60
Query: 61 LLAPYRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTT 120
LLAPYRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTT
Sbjct: 61 LLAPYRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTT 120
Query: 121 PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA 180
PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA
Sbjct: 121 PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA 180
Query: 181 IQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPE 240
IQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPE
Sbjct: 181 IQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPE 240
Query: 241 NRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMG 300
NRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMG
Sbjct: 241 NRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMG 300
Query: 301 LKRAHQH 307
LKRAHQH
Sbjct: 301 LKRAHQH 307
>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
Length = 315
Score = 110 bits (276), Expect = 1e-24
Identities = 85/297 (28%), Positives = 143/297 (48%), Gaps = 26/297 (8%)
Query: 7 YESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEII----KEEGLL 62
YE+L+ V+G V S A+ PLD ++R V + + + + +L + K +GL
Sbjct: 23 YENLIAGVSGGVLSNLAL---HPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLR 79
Query: 63 APYRGWFPVISSLCCSNFVYFYTFNSLKALWVKG--QHSTTGKDLVVGFVAGVVNVLLTT 120
Y+G P I S +YF+ +N++K+ +G + + LV AG + + +T
Sbjct: 80 GLYQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITN 139
Query: 121 PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA 180
PLWV TRL LQ N YKG+ D +I + EG+ L+ G P L + A
Sbjct: 140 PLWVTKTRLMLQYDAVVNSP--HRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGTSHGA 197
Query: 181 IQFMFYEGLKRQLLK-----KRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRH 235
+QFM YE LK + + +LS+++ + A++K A TYP Q V R
Sbjct: 198 LQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVV-------RA 250
Query: 236 RLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLT 292
RL ++ ++ ++ + R+ G+ G YKG+ L++ + F+VYE ++
Sbjct: 251 RLQDQHMFYS---GVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVS 304
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 86.3 bits (212), Expect = 3e-17
Identities = 81/297 (27%), Positives = 129/297 (43%), Gaps = 31/297 (10%)
Query: 13 AVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTT-----HMVLL---EIIKEEGLLAP 64
AVAG+V + + P D ++R Q+ +R S++ H +L +I++EEG A
Sbjct: 19 AVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAF 78
Query: 65 YRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTT---- 120
++G P V F +F L L +G ++ V FV G + + T
Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGS-VYDAREFSVHFVCGGLAACMATLTVH 137
Query: 121 PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA 180
P+ V+ TR QG P Y + A + R EG + G P+L+ +F A
Sbjct: 138 PVDVLRTRFAAQGE--------PKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYA 189
Query: 181 -IQFMFYEGLKR----QLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRH 235
+QF Y LK + + K +L + G+ A I+ T+TYPL + L+ G
Sbjct: 190 GLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGG- 248
Query: 236 RLNPENRTLGSLRNILYLLH---QRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYE 289
G +R L+ Q +++ G +G +KGL LL+ L+ MF YE
Sbjct: 249 -FEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 69.3 bits (168), Expect = 4e-12
Identities = 55/200 (27%), Positives = 96/200 (48%), Gaps = 14/200 (7%)
Query: 96 GQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQ 155
G+++T + V G V+G+V L +P V+ R +LQ + D Y GI+ A Q
Sbjct: 10 GRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSD-PSAKYHGILQASRQ 68
Query: 156 IIRDEGISALWNGTFPS-LLLVFNPAIQFMFYEGLKRQLLKKRMKLSSLDV---FIIGAV 211
I+++EG +A W G P+ +L + A+QF+ +E L +L+ + + + F+ G +
Sbjct: 69 ILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML-TELVHRGSVYDAREFSVHFVCGGL 127
Query: 212 AKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLE 271
A +AT +P+ +++ R E + +LR+ + ++ R G YKGL
Sbjct: 128 AACMATLTVHPVDVLRT-----RFAAQGEPKVYNTLRHAVGTMY---RSEGPQVFYKGLA 179
Query: 272 AKLLQTVLTAALMFLVYEKL 291
L+ A L F Y L
Sbjct: 180 PTLIAIFPYAGLQFSCYSSL 199
Score = 32.3 bits (72), Expect = 0.54
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 10/89 (11%)
Query: 8 ESLVHAVAGAVGSVTAMTVFFPLDTARLRLQV----------DEKRKSKTTHMVLLEIIK 57
E+L + + G+ V + T+ +PLD + RLQV + R+ K ++++
Sbjct: 215 ENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQ 274
Query: 58 EEGLLAPYRGWFPVISSLCCSNFVYFYTF 86
+EG L ++G P + S F+++
Sbjct: 275 KEGALGFFKGLSPSLLKAALSTGFMFFSY 303
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 86.3 bits (212), Expect = 3e-17
Identities = 81/297 (27%), Positives = 129/297 (43%), Gaps = 31/297 (10%)
Query: 13 AVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTT-----HMVLL---EIIKEEGLLAP 64
AVAG+V + + P D ++R Q+ +R S++ H +L +I++EEG A
Sbjct: 19 AVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAF 78
Query: 65 YRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTT---- 120
++G P V F +F L L +G ++ V FV G + + T
Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGS-VYDAREFSVHFVCGGLAACMATLTVH 137
Query: 121 PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA 180
P+ V+ TR QG P Y + A + R EG + G P+L+ +F A
Sbjct: 138 PVDVLRTRFAAQGE--------PKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYA 189
Query: 181 -IQFMFYEGLKR----QLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRH 235
+QF Y LK + + K +L + G+ A I+ T+TYPL + L+ G
Sbjct: 190 GLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGG- 248
Query: 236 RLNPENRTLGSLRNILYLLH---QRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYE 289
G +R L+ Q +++ G +G +KGL LL+ L+ MF YE
Sbjct: 249 -FEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 69.3 bits (168), Expect = 4e-12
Identities = 55/200 (27%), Positives = 96/200 (48%), Gaps = 14/200 (7%)
Query: 96 GQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQ 155
G+++T + V G V+G+V L +P V+ R +LQ + D Y GI+ A Q
Sbjct: 10 GRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSD-PSAKYHGILQASRQ 68
Query: 156 IIRDEGISALWNGTFPS-LLLVFNPAIQFMFYEGLKRQLLKKRMKLSSLDV---FIIGAV 211
I+++EG +A W G P+ +L + A+QF+ +E L +L+ + + + F+ G +
Sbjct: 69 ILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML-TELVHRGSVYDAREFSVHFVCGGL 127
Query: 212 AKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLE 271
A +AT +P+ +++ R E + +LR+ + ++ R G YKGL
Sbjct: 128 AACMATLTVHPVDVLRT-----RFAAQGEPKVYNTLRHAVGTMY---RSEGPQVFYKGLA 179
Query: 272 AKLLQTVLTAALMFLVYEKL 291
L+ A L F Y L
Sbjct: 180 PTLIAIFPYAGLQFSCYSSL 199
Score = 32.3 bits (72), Expect = 0.54
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 10/89 (11%)
Query: 8 ESLVHAVAGAVGSVTAMTVFFPLDTARLRLQV----------DEKRKSKTTHMVLLEIIK 57
E+L + + G+ V + T+ +PLD + RLQV + R+ K ++++
Sbjct: 215 ENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQ 274
Query: 58 EEGLLAPYRGWFPVISSLCCSNFVYFYTF 86
+EG L ++G P + S F+++
Sbjct: 275 KEGALGFFKGLSPSLLKAALSTGFMFFSY 303
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 86.3 bits (212), Expect = 3e-17
Identities = 81/297 (27%), Positives = 129/297 (43%), Gaps = 31/297 (10%)
Query: 13 AVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTT-----HMVLL---EIIKEEGLLAP 64
AVAG+V + + P D ++R Q+ +R S++ H +L +I++EEG A
Sbjct: 19 AVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAF 78
Query: 65 YRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTT---- 120
++G P V F +F L L +G ++ V FV G + + T
Sbjct: 79 WKGHVPAQILSIGYGAVQFLSFEMLTELVHRGS-VYDAREFSVHFVCGGLAACMATLTVH 137
Query: 121 PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA 180
P+ V+ TR QG P Y + A + R EG + G P+L+ +F A
Sbjct: 138 PVDVLRTRFAAQGE--------PKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYA 189
Query: 181 -IQFMFYEGLKR----QLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRH 235
+QF Y LK + + K +L + G+ A I+ T+TYPL + L+ G
Sbjct: 190 GLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGG- 248
Query: 236 RLNPENRTLGSLRNILYLLH---QRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYE 289
G +R L+ Q +++ G +G +KGL LL+ L+ MF YE
Sbjct: 249 -FEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 69.3 bits (168), Expect = 4e-12
Identities = 55/200 (27%), Positives = 96/200 (48%), Gaps = 14/200 (7%)
Query: 96 GQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQ 155
G+++T + V G V+G+V L +P V+ R +LQ + D Y GI+ A Q
Sbjct: 10 GRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSD-PSAKYHGILQASRQ 68
Query: 156 IIRDEGISALWNGTFPS-LLLVFNPAIQFMFYEGLKRQLLKKRMKLSSLDV---FIIGAV 211
I+++EG +A W G P+ +L + A+QF+ +E L +L+ + + + F+ G +
Sbjct: 69 ILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML-TELVHRGSVYDAREFSVHFVCGGL 127
Query: 212 AKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLE 271
A +AT +P+ +++ R E + +LR+ + ++ R G YKGL
Sbjct: 128 AACMATLTVHPVDVLRT-----RFAAQGEPKVYNTLRHAVGTMY---RSEGPQVFYKGLA 179
Query: 272 AKLLQTVLTAALMFLVYEKL 291
L+ A L F Y L
Sbjct: 180 PTLIAIFPYAGLQFSCYSSL 199
Score = 32.3 bits (72), Expect = 0.54
Identities = 21/89 (23%), Positives = 42/89 (47%), Gaps = 10/89 (11%)
Query: 8 ESLVHAVAGAVGSVTAMTVFFPLDTARLRLQV----------DEKRKSKTTHMVLLEIIK 57
E+L + + G+ V + T+ +PLD + RLQV + R+ K ++++
Sbjct: 215 ENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQ 274
Query: 58 EEGLLAPYRGWFPVISSLCCSNFVYFYTF 86
+EG L ++G P + S F+++
Sbjct: 275 KEGALGFFKGLSPSLLKAALSTGFMFFSY 303
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/293 (25%), Positives = 131/293 (44%), Gaps = 26/293 (8%)
Query: 26 VFFPLDTARLRLQVD-EKRKSKTTHMV--------LLEIIKEEGLLAPYRGWFPVISSLC 76
V FPLDTA++RLQ+ E + +T +V +L +++ EG +PY G +
Sbjct: 30 VTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQM 89
Query: 77 CSNFVYFYTFNSLKALWV-KG-QHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGA 134
+ ++S+K ++ KG +S+ ++ G G + V P VV R Q +
Sbjct: 90 SFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRF--QAS 147
Query: 135 KFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLL--LVFNPAIQFMFYEGLKRQ 192
Y G +DA+ I R+EG+ LW GT P+++ + N A + + Y+ LK +
Sbjct: 148 IHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA-EVVTYDILKEK 206
Query: 193 LLKKRMKLSSLDVFIIGAV-AKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNIL 251
LL + + + A A AT V P+ V++ R+ +P + L ++
Sbjct: 207 LLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKT-----RYMNSPPGQYFSPLDCMI 261
Query: 252 YLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKRA 304
++ Q G YKG L+ +MF+ YE+L A V L+ +
Sbjct: 262 KMVAQE----GPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALMKVQMLRES 310
Score = 47.0 bits (110), Expect = 2e-05
Identities = 44/182 (24%), Positives = 78/182 (42%), Gaps = 14/182 (7%)
Query: 117 LLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLV 176
L+T PL RL++QG + Y+G++ ++R EG + +NG L
Sbjct: 29 LVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQ 88
Query: 177 FN-PAIQFMFYEGLKRQLLKKRMKLSSLDVFII-GAVAKAIATTVTYPLQTV----QSIL 230
+ +I+ Y+ +K+ K SSL I+ G A+A T P V Q+ +
Sbjct: 89 MSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASI 148
Query: 231 RFGRHRLNPE-NRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYE 289
G R + + + T+ + R I R G+ GL+KG +++ + + Y+
Sbjct: 149 HLGPSRSDRKYSGTMDAYRTI-------AREEGVRGLWKGTLPNIMRNAIVNCAEVVTYD 201
Query: 290 KL 291
L
Sbjct: 202 IL 203
Score = 30.0 bits (66), Expect = 2.7
Identities = 22/86 (25%), Positives = 36/86 (41%)
Query: 206 FIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMG 265
F+ A A VT+PL T + L+ + L R +L + VR G
Sbjct: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
Query: 266 LYKGLEAKLLQTVLTAALMFLVYEKL 291
Y GL A L + + A++ +Y+ +
Sbjct: 77 PYNGLVAGLQRQMSFASIRIGLYDSV 102
>gi|157388989 solute carrier family 25, member 36 isoform a [Homo
sapiens]
Length = 311
Score = 83.2 bits (204), Expect = 3e-16
Identities = 77/315 (24%), Positives = 135/315 (42%), Gaps = 49/315 (15%)
Query: 8 ESLVHAVAGAVGSVTAMTVFFPLDTARLRLQ------------VDEKRKSKTTHMV---- 51
++LVH AG G + PL+ + RLQ ++ + +V
Sbjct: 5 DTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGP 64
Query: 52 ---LLEIIKEEGLLAPYRGWFPVISSLCCSNFVYFYTFNSLKA-LWVKGQHSTTGKDLVV 107
L I+++EG + +RG P + + S +YF +++ K L +T ++
Sbjct: 65 LHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMIS 124
Query: 108 GFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWN 167
+AG + T P+W++ TRL+L A+ R E G + ++ + +G+ +
Sbjct: 125 AAMAGFTAITATNPIWLIKTRLQLD-ARNRGE-----RRMGAFECVRKVYQTDGLKGFYR 178
Query: 168 GTFPSLLLVFNPAIQFMFYEGLKRQLL-----------KKRMKLSS--LDVFIIGAVAKA 214
G S + I F+ YE +K++LL ++ +K +S + + + A +K
Sbjct: 179 GMSASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKT 238
Query: 215 IATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKL 274
ATT+ YP + V R RL E S L LL V+ G LY+GL L
Sbjct: 239 CATTIAYPHEVV-------RTRLREEGTKYRSFFQTLSLL---VQEEGYGSLYRGLTTHL 288
Query: 275 LQTVLTAALMFLVYE 289
++ + A+M YE
Sbjct: 289 VRQIPNTAIMMATYE 303
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 82.8 bits (203), Expect = 3e-16
Identities = 80/278 (28%), Positives = 124/278 (44%), Gaps = 23/278 (8%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVD--EKRKSKTTHMVLLEIIKEEGLLAPYRG-WFP 70
+AG G V + V P DT ++RLQV EK + + T IIK+E +L Y+G P
Sbjct: 6 LAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLGSP 65
Query: 71 VISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLK 130
++ + V+ N+L+AL H + + G AG + ++ P+ + TRL+
Sbjct: 66 LMGLTFINALVFGVQGNTLRAL----GHDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQ 121
Query: 131 LQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA--IQFMFYEG 188
LQ A YKG +D QI EG+ + N S LL P+ + F+ Y+
Sbjct: 122 LQDAG------PARTYKGSLDCLAQIYGHEGLRGV-NRGMVSTLLRETPSFGVYFLTYDA 174
Query: 189 LKRQL-LKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSL 247
L R L + +L + + G + ++ TYP+ V+S L+ R P
Sbjct: 175 LTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPR------Y 228
Query: 248 RNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMF 285
R IL +HQ R G +GL + LL+ A F
Sbjct: 229 RGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATF 266
>gi|157388991 solute carrier family 25, member 36 isoform b [Homo
sapiens]
Length = 310
Score = 80.1 bits (196), Expect = 2e-15
Identities = 76/315 (24%), Positives = 133/315 (42%), Gaps = 50/315 (15%)
Query: 8 ESLVHAVAGAVGSVTAMTVFFPLDTARLRLQ------------VDEKRKSKTTHMV---- 51
++LVH AG G + PL+ + RLQ ++ + +V
Sbjct: 5 DTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGP 64
Query: 52 ---LLEIIKEEGLLAPYRGWFPVISSLCCSNFVYFYTFNSLKA-LWVKGQHSTTGKDLVV 107
L I+++EG + +RG P + + S +YF +++ K L +T ++
Sbjct: 65 LHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMIS 124
Query: 108 GFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWN 167
+AG + T P+W++ TRL+L A+ R E G + ++ + +G+ +
Sbjct: 125 AAMAGFTAITATNPIWLIKTRLQLD-ARNRGE-----RRMGAFECVRKVYQTDGLKGFYR 178
Query: 168 GTFPSLLLVFNPAIQFMFYEGLKRQLL-----------KKRMKLSS--LDVFIIGAVAKA 214
G S + I F+ YE +K++LL ++ +K +S + + + A +K
Sbjct: 179 GMSASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKT 238
Query: 215 IATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKL 274
ATT+ YP R RL E S L LL V+ G LY+GL L
Sbjct: 239 CATTIAYP--------HVVRTRLREEGTKYRSFFQTLSLL---VQEEGYGSLYRGLTTHL 287
Query: 275 LQTVLTAALMFLVYE 289
++ + A+M YE
Sbjct: 288 VRQIPNTAIMMATYE 302
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 79.0 bits (193), Expect = 5e-15
Identities = 75/293 (25%), Positives = 132/293 (45%), Gaps = 32/293 (10%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLL----EIIKEEGLLAPYRGWF 69
VAGAV + T PLD ++ +QV SKT + +L ++ E G+ + +RG
Sbjct: 190 VAGAVAGAVSRTGTAPLDRLKVFMQV---HASKTNRLNILGGLRSMVLEGGIRSLWRGNG 246
Query: 70 PVISSLCCSNFVYFYTFNSLKALWVKGQHST--TGKDLVVGFVAGVVNVLLTTPLWVVNT 127
+ + + + F + +K + GQ T + V G +AG + P+ V+ T
Sbjct: 247 INVLKIAPESAIKFMAYEQIKRA-ILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKT 305
Query: 128 RLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFY 186
RL L+ YKG++D +I+ EG A + G P++L + A I Y
Sbjct: 306 RLTLRRTG---------QYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVY 356
Query: 187 EGLKRQLLKKRMKLSS----LDVFIIGAVAKAIATTVTYPLQTVQSILRFGRH-RLNPEN 241
E LK L++ S+ L + G ++ +YPL V++ ++ P+
Sbjct: 357 ETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQL 416
Query: 242 RTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAA 294
LG LR+IL + G+ GLY+G+ ++ + ++ ++VYE + A
Sbjct: 417 SMLGLLRHIL-------SQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQA 462
Score = 72.0 bits (175), Expect = 6e-13
Identities = 56/199 (28%), Positives = 93/199 (46%), Gaps = 21/199 (10%)
Query: 97 QHSTTG---KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAF 153
Q TG K LV G VAG V+ T PL + +++ +K TN I+
Sbjct: 178 QEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASK--------TNRLNILGGL 229
Query: 154 HQIIRDEGISALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVA 212
++ + GI +LW G ++L + AI+FM YE +KR +L ++ L + F+ G++A
Sbjct: 230 RSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLA 289
Query: 213 KAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEA 272
A A T+ YP++ +++ L R G + +L + + R G Y+G
Sbjct: 290 GATAQTIIYPMEVLKTRLTL---------RRTGQYKGLLDCARRILEREGPRAFYRGYLP 340
Query: 273 KLLQTVLTAALMFLVYEKL 291
+L + A + VYE L
Sbjct: 341 NVLGIIPYAGIDLAVYETL 359
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/202 (23%), Positives = 91/202 (45%), Gaps = 18/202 (8%)
Query: 3 SVLSYESLVHA----VAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKE 58
++L + +H VAG++ TA T+ +P++ + RL + + K I++
Sbjct: 269 AILGQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILER 328
Query: 59 EGLLAPYRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKD------LVVGFVAG 112
EG A YRG+ P + + + + +LK W++ Q+S D L G ++
Sbjct: 329 EGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQ-QYSHDSADPGILVLLACGTISS 387
Query: 113 VVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPS 172
+ + PL +V TR++ Q + I ++ I+ EG+ L+ G P+
Sbjct: 388 TCGQIASYPLALVRTRMQAQAS------IEGGPQLSMLGLLRHILSQEGMRGLYRGIAPN 441
Query: 173 LLLVFNP-AIQFMFYEGLKRQL 193
+ V +I ++ YE +K+ L
Sbjct: 442 FMKVIPAVSISYVVYENMKQAL 463
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 78.6 bits (192), Expect = 7e-15
Identities = 71/298 (23%), Positives = 121/298 (40%), Gaps = 29/298 (9%)
Query: 11 VHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMV----------LLEIIKEEG 60
V + + A + FPLDTA++RLQ+ + + +L +++ EG
Sbjct: 15 VKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEG 74
Query: 61 LLAPYRGWFPVISSLCCSNFVYFYTFNSLKALWVKG-QHSTTGKDLVVGFVAGVVNVLLT 119
+ Y G + V ++S+K + KG +H++ G L+ G G + V +
Sbjct: 75 PRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVA 134
Query: 120 TPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLL--LVF 177
P VV R + Q Y+ ++A+ I R+EG LW GT P++ +
Sbjct: 135 QPTDVVKVRFQAQARAGGGR-----RYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189
Query: 178 NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTV-TYPLQTVQSILRFGRHR 236
N A + + Y+ +K LLK + L A TTV P+ V++
Sbjct: 190 NCA-ELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKT-------- 240
Query: 237 LNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAA 294
N LG + + +++ G YKG L+ +MF+ YE+L A
Sbjct: 241 -RYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRA 297
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 78.2 bits (191), Expect = 9e-15
Identities = 72/286 (25%), Positives = 126/286 (44%), Gaps = 24/286 (8%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMV-LLEIIKEEGLLAPYRGWFPVI 72
+AG + + T PLD ++ +QV + K +++KE G+ + +RG +
Sbjct: 199 LAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNV 258
Query: 73 SSLCCSNFVYFYTFNSLKALWVK-GQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKL 131
+ V F+ + K L + GQ T + + G +AG P+ V+ TRL +
Sbjct: 259 IKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV 318
Query: 132 QGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFYEGLK 190
Y GI D +I++ EG+ A + G P+LL + A I YE LK
Sbjct: 319 GKTG---------QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLK 369
Query: 191 RQLLKKRMKLS-SLDVFII---GAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGS 246
L K S + V ++ GA++ +YPL V R R+ + GS
Sbjct: 370 SYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALV-------RTRMQAQAMLEGS 422
Query: 247 LR-NILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ N++ L + + + GI GLY+G+ ++ + + ++VYE +
Sbjct: 423 PQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENM 468
Score = 71.2 bits (173), Expect = 1e-12
Identities = 49/190 (25%), Positives = 91/190 (47%), Gaps = 18/190 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGI 162
+ L+ G +AG V+ T PL + +++ G+K ++ I F Q++++ GI
Sbjct: 196 RQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSK--------SDKMNIFGGFRQMVKEGGI 247
Query: 163 SALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTY 221
+LW G +++ + A++F YE K+ L ++ K+ + + FI G++A A A T Y
Sbjct: 248 RSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIY 307
Query: 222 PLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTA 281
P++ +++ L G+ G I + ++ G+ YKG LL + A
Sbjct: 308 PMEVMKTRLAVGK---------TGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYA 358
Query: 282 ALMFLVYEKL 291
+ VYE L
Sbjct: 359 GIDLAVYELL 368
Score = 61.2 bits (147), Expect = 1e-09
Identities = 47/187 (25%), Positives = 89/187 (47%), Gaps = 14/187 (7%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWFPVIS 73
++G++ TA T +P++ + RL V + + + +I+K EGL A Y+G+ P +
Sbjct: 293 ISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLL 352
Query: 74 SLCCSNFVYFYTFNSLKALWVK--GQHSTTGKDLVV---GFVAGVVNVLLTTPLWVVNTR 128
+ + + LK+ W+ + S +V+ G ++ L + PL +V TR
Sbjct: 353 GIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTR 412
Query: 129 LKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA--IQFMFY 186
++ Q + + ++ F +II EGI L+ G P+ + V PA I ++ Y
Sbjct: 413 MQAQAMLEGSPQL------NMVGLFRRIISKEGIPGLYRGITPNFMKVL-PAVGISYVVY 465
Query: 187 EGLKRQL 193
E +K+ L
Sbjct: 466 ENMKQTL 472
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 78.2 bits (191), Expect = 9e-15
Identities = 72/286 (25%), Positives = 126/286 (44%), Gaps = 24/286 (8%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMV-LLEIIKEEGLLAPYRGWFPVI 72
+AG + + T PLD ++ +QV + K +++KE G+ + +RG +
Sbjct: 180 LAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNV 239
Query: 73 SSLCCSNFVYFYTFNSLKALWVK-GQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKL 131
+ V F+ + K L + GQ T + + G +AG P+ V+ TRL +
Sbjct: 240 IKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV 299
Query: 132 QGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFYEGLK 190
Y GI D +I++ EG+ A + G P+LL + A I YE LK
Sbjct: 300 GKTG---------QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLK 350
Query: 191 RQLLKKRMKLS-SLDVFII---GAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGS 246
L K S + V ++ GA++ +YPL V R R+ + GS
Sbjct: 351 SYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALV-------RTRMQAQAMLEGS 403
Query: 247 LR-NILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ N++ L + + + GI GLY+G+ ++ + + ++VYE +
Sbjct: 404 PQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENM 449
Score = 71.2 bits (173), Expect = 1e-12
Identities = 49/190 (25%), Positives = 91/190 (47%), Gaps = 18/190 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGI 162
+ L+ G +AG V+ T PL + +++ G+K ++ I F Q++++ GI
Sbjct: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSK--------SDKMNIFGGFRQMVKEGGI 228
Query: 163 SALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTY 221
+LW G +++ + A++F YE K+ L ++ K+ + + FI G++A A A T Y
Sbjct: 229 RSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIY 288
Query: 222 PLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTA 281
P++ +++ L G+ G I + ++ G+ YKG LL + A
Sbjct: 289 PMEVMKTRLAVGK---------TGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYA 339
Query: 282 ALMFLVYEKL 291
+ VYE L
Sbjct: 340 GIDLAVYELL 349
Score = 61.2 bits (147), Expect = 1e-09
Identities = 47/187 (25%), Positives = 89/187 (47%), Gaps = 14/187 (7%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWFPVIS 73
++G++ TA T +P++ + RL V + + + +I+K EGL A Y+G+ P +
Sbjct: 274 ISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLL 333
Query: 74 SLCCSNFVYFYTFNSLKALWVK--GQHSTTGKDLVV---GFVAGVVNVLLTTPLWVVNTR 128
+ + + LK+ W+ + S +V+ G ++ L + PL +V TR
Sbjct: 334 GIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTR 393
Query: 129 LKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA--IQFMFY 186
++ Q + + ++ F +II EGI L+ G P+ + V PA I ++ Y
Sbjct: 394 MQAQAMLEGSPQL------NMVGLFRRIISKEGIPGLYRGITPNFMKVL-PAVGISYVVY 446
Query: 187 EGLKRQL 193
E +K+ L
Sbjct: 447 ENMKQTL 453
>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
Length = 338
Score = 75.9 bits (185), Expect = 4e-14
Identities = 70/292 (23%), Positives = 129/292 (44%), Gaps = 32/292 (10%)
Query: 12 HAVAGAVGSVTAMTVFFPLDTARLRLQ---VDEKRKSKTTHMVLLEIIKEEGLLAPYRGW 68
H AGA+ + +V +P+D+ + R+Q D K + + + L +I++ EG P RG
Sbjct: 48 HMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGV 107
Query: 69 FPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDL---VVGFVAGVVNVLLTTPLWVV 125
+I ++ +YF + ++K H L + G +A +++ + P VV
Sbjct: 108 NVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVV 167
Query: 126 NTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLL-VFNPAIQFM 184
RL++ ++ R+ I + R EG+ A + L + + +I F+
Sbjct: 168 KQRLQMYNSQHRS----------AISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFI 217
Query: 185 FYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTL 244
YE L+ Q+ R + I G +A A+A T PL +++ LN +
Sbjct: 218 TYEFLQEQVNPHR-TYNPQSHIISGGLAGALAAAATTPLDVCKTL-------LNTQENVA 269
Query: 245 GSLRNILYLLHQRVRRF-------GIMGLYKGLEAKLLQTVLTAALMFLVYE 289
SL NI L F G+ G +KG++A+++ + + A+ + VYE
Sbjct: 270 LSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYE 321
Score = 45.1 bits (105), Expect = 8e-05
Identities = 40/191 (20%), Positives = 84/191 (43%), Gaps = 2/191 (1%)
Query: 10 LVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWF 69
L + +AG++ ++ V P + + RLQ+ + ++ + + + EGL A YR +
Sbjct: 144 LANGIAGSMATLLHDAVMNPAEVVKQRLQM-YNSQHRSAISCIRTVWRTEGLGAFYRSYT 202
Query: 70 PVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRL 129
++ ++F T+ L+ + ++ G +AG + TTPL V T L
Sbjct: 203 TQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIISGGLAGALAAAATTPLDVCKTLL 262
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVF-NPAIQFMFYEG 188
Q + + G+ +AF + + G++ + G ++ + AI + YE
Sbjct: 263 NTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEF 322
Query: 189 LKRQLLKKRMK 199
K L K++++
Sbjct: 323 FKYFLTKRQLE 333
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 75.5 bits (184), Expect = 6e-14
Identities = 72/289 (24%), Positives = 130/289 (44%), Gaps = 26/289 (8%)
Query: 12 HAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMV-LLEIIKEEGLLAPYRGWFP 70
H VAG + T PLD ++ +QV R + + ++I+E G + +RG
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 248
Query: 71 VISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKD-LVVGFVAGVVNVLLTTPLWVVNTRL 129
+ + + + F + +K L Q + + LV G +AG + P+ V+ TR+
Sbjct: 249 NVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 308
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFYEG 188
L+ Y G++D +I+ EG++A + G P++L + A I YE
Sbjct: 309 ALRKTG---------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET 359
Query: 189 LKRQLLKKRMKLSSLD--VFII---GAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRT 243
LK L+ ++S D VF++ G ++ +YPL V++ ++ T
Sbjct: 360 LKNAWLQ-HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT 418
Query: 244 LGSL-RNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ SL ++IL R G GLY+GL ++ + ++ ++VYE L
Sbjct: 419 MSSLFKHIL-------RTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 460
Score = 67.4 bits (163), Expect = 2e-11
Identities = 52/193 (26%), Positives = 90/193 (46%), Gaps = 18/193 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGI 162
+ LV G AG V+ T PL + +++ ++ +N GI+ F Q+IR+ G
Sbjct: 188 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASR--------SNNMGIVGGFTQMIREGGA 239
Query: 163 SALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTY 221
+LW G ++L + AI+FM YE +KR + + L + + G++A AIA + Y
Sbjct: 240 RSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIY 299
Query: 222 PLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTA 281
P++ +++ + R G +L + + R G+ YKG +L + A
Sbjct: 300 PMEVLKTRMAL---------RKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYA 350
Query: 282 ALMFLVYEKLTAA 294
+ VYE L A
Sbjct: 351 GIDLAVYETLKNA 363
Score = 30.0 bits (66), Expect = 2.7
Identities = 22/100 (22%), Positives = 42/100 (42%), Gaps = 8/100 (8%)
Query: 207 IIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGL 266
+ G A A++ T T PL ++ +++ R N G Q +R G L
Sbjct: 191 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG--------FTQMIREGGARSL 242
Query: 267 YKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKRAHQ 306
++G +L+ +A+ F+ YE++ + R H+
Sbjct: 243 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHE 282
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 75.5 bits (184), Expect = 6e-14
Identities = 72/289 (24%), Positives = 130/289 (44%), Gaps = 26/289 (8%)
Query: 12 HAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMV-LLEIIKEEGLLAPYRGWFP 70
H VAG + T PLD ++ +QV R + + ++I+E G + +RG
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 282
Query: 71 VISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKD-LVVGFVAGVVNVLLTTPLWVVNTRL 129
+ + + + F + +K L Q + + LV G +AG + P+ V+ TR+
Sbjct: 283 NVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 342
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFYEG 188
L+ Y G++D +I+ EG++A + G P++L + A I YE
Sbjct: 343 ALRKTG---------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET 393
Query: 189 LKRQLLKKRMKLSSLD--VFII---GAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRT 243
LK L+ ++S D VF++ G ++ +YPL V++ ++ T
Sbjct: 394 LKNAWLQ-HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT 452
Query: 244 LGSL-RNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ SL ++IL R G GLY+GL ++ + ++ ++VYE L
Sbjct: 453 MSSLFKHIL-------RTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 494
Score = 67.4 bits (163), Expect = 2e-11
Identities = 52/193 (26%), Positives = 90/193 (46%), Gaps = 18/193 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGI 162
+ LV G AG V+ T PL + +++ ++ +N GI+ F Q+IR+ G
Sbjct: 222 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASR--------SNNMGIVGGFTQMIREGGA 273
Query: 163 SALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTY 221
+LW G ++L + AI+FM YE +KR + + L + + G++A AIA + Y
Sbjct: 274 RSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIY 333
Query: 222 PLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTA 281
P++ +++ + R G +L + + R G+ YKG +L + A
Sbjct: 334 PMEVLKTRMAL---------RKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYA 384
Query: 282 ALMFLVYEKLTAA 294
+ VYE L A
Sbjct: 385 GIDLAVYETLKNA 397
Score = 30.0 bits (66), Expect = 2.7
Identities = 22/100 (22%), Positives = 42/100 (42%), Gaps = 8/100 (8%)
Query: 207 IIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGL 266
+ G A A++ T T PL ++ +++ R N G Q +R G L
Sbjct: 225 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG--------FTQMIREGGARSL 276
Query: 267 YKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKRAHQ 306
++G +L+ +A+ F+ YE++ + R H+
Sbjct: 277 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHE 316
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 75.5 bits (184), Expect = 6e-14
Identities = 74/298 (24%), Positives = 137/298 (45%), Gaps = 35/298 (11%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQV----DEKRKSKTTHMVLLEIIKEEGLLAPYRGWF 69
+ G++ + +F PLD + RLQ D + VLL++++ E LL ++G
Sbjct: 32 LCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLWKGMS 91
Query: 70 PVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRL 129
P I +YF T SLK +++G T + +++G + V + +P+ V+ TR
Sbjct: 92 PSIVRCVPGVGIYFGTLYSLKQYFLRGHPPTALESVMLGVGSRSVAGVCMSPITVIKTR- 150
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLL--LVFNPAIQFMFYE 187
+ K+ Y+ I A I EG L++G +LL F+ I MFY
Sbjct: 151 -YESGKY--------GYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFS-GIYLMFYN 200
Query: 188 GLKRQLLKKRMKLSSLDV--FIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNP-ENRTL 244
K + ++ + + + F G A +A+ VT P +++ + +L P + + +
Sbjct: 201 QTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHM-----QLYPLKFQWI 255
Query: 245 GSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLK 302
G +++ + +G+ G ++G + L+ L AA+ + VYE++ A MGLK
Sbjct: 256 GQAVTLIF------KDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAK----MGLK 303
>gi|13775208 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 31 [Homo
sapiens]
Length = 315
Score = 75.5 bits (184), Expect = 6e-14
Identities = 53/189 (28%), Positives = 94/189 (49%), Gaps = 17/189 (8%)
Query: 10 LVHAVAGAVGSVTAMTVFFPLDTARLRLQVD-----EKRKSKTTHMVLLEIIKEEGLLAP 64
L + +G T++ V +PLD AR RL VD E+R+ K +++I K +G+
Sbjct: 126 LANLASGGAAGATSLCVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGL 185
Query: 65 YRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNV---LLTTP 121
Y+G+ + + YF ++++K L K + + LV F+A VV +L+ P
Sbjct: 186 YQGFGVSVQGIIVYRASYFGAYDTVKGLLPKPKKTPF---LVSFFIAQVVTTCSGILSYP 242
Query: 122 LWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPAI 181
V R+ +Q + + + YKG +D F +I + EGIS+ + G F ++L A+
Sbjct: 243 FDTVRRRMMMQSGEAKRQ------YKGTLDCFVKIYQHEGISSFFRGAFSNVLRGTGGAL 296
Query: 182 QFMFYEGLK 190
+ Y+ +K
Sbjct: 297 VLVLYDKIK 305
Score = 59.3 bits (142), Expect = 4e-09
Identities = 55/204 (26%), Positives = 89/204 (43%), Gaps = 26/204 (12%)
Query: 99 STTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVP-TNYKGIIDAFHQII 157
S+ GKDL+ G VA V+ P+ V L++Q + ++ I P YKG++D +I
Sbjct: 18 SSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQAS---SKQISPEARYKGMVDCLVRIP 74
Query: 158 RDEGISALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLL-----KKRMKLSSLDVFIIGAV 211
R++G + W G +++ F A+ F F + K+ + +K+ L G
Sbjct: 75 REQGFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGA 134
Query: 212 AKAIATTVTYPLQTVQSILRFGRHRL------NPENRTLGSLRNILYLLHQRVRRFGIMG 265
A A + V YPL F R RL PE R L + + + + GI G
Sbjct: 135 AGATSLCVVYPLD-------FARTRLGVDIGKGPEERQFKGLGDCIMKI---AKSDGIAG 184
Query: 266 LYKGLEAKLLQTVLTAALMFLVYE 289
LY+G + ++ A F Y+
Sbjct: 185 LYQGFGVSVQGIIVYRASYFGAYD 208
Score = 57.4 bits (137), Expect = 2e-08
Identities = 68/292 (23%), Positives = 123/292 (42%), Gaps = 26/292 (8%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVDEKRK-----SKTTHMV--LLEIIKEEGLLAPYR 66
+AG V + + T P++ +L LQV K ++ MV L+ I +E+G + +R
Sbjct: 25 LAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFSFWR 84
Query: 67 GWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTG------KDLVVGFVAGVVNVLLTT 120
G + + + F + K L++ G + +L G AG ++ +
Sbjct: 85 GNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLCVVY 144
Query: 121 PLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLL-LVFNP 179
PL TRL + K E +KG+ D +I + +GI+ L+ G S+ ++
Sbjct: 145 PLDFARTRLGVDIGKGPEE----RQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYR 200
Query: 180 AIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNP 239
A F Y+ +K LL K K L F I V + ++YP TV+ R +
Sbjct: 201 ASYFGAYDTVK-GLLPKPKKTPFLVSFFIAQVVTTCSGILSYPFDTVR------RRMMMQ 253
Query: 240 ENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ L + + GI ++G + +L+ AL+ ++Y+K+
Sbjct: 254 SGEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVLRGT-GGALVLVLYDKI 304
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 75.5 bits (184), Expect = 6e-14
Identities = 72/289 (24%), Positives = 130/289 (44%), Gaps = 26/289 (8%)
Query: 12 HAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMV-LLEIIKEEGLLAPYRGWFP 70
H VAG + T PLD ++ +QV R + + ++I+E G + +RG
Sbjct: 209 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 268
Query: 71 VISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKD-LVVGFVAGVVNVLLTTPLWVVNTRL 129
+ + + + F + +K L Q + + LV G +AG + P+ V+ TR+
Sbjct: 269 NVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 328
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFYEG 188
L+ Y G++D +I+ EG++A + G P++L + A I YE
Sbjct: 329 ALRKTG---------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET 379
Query: 189 LKRQLLKKRMKLSSLD--VFII---GAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRT 243
LK L+ ++S D VF++ G ++ +YPL V++ ++ T
Sbjct: 380 LKNAWLQ-HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT 438
Query: 244 LGSL-RNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ SL ++IL R G GLY+GL ++ + ++ ++VYE L
Sbjct: 439 MSSLFKHIL-------RTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 480
Score = 67.4 bits (163), Expect = 2e-11
Identities = 52/193 (26%), Positives = 90/193 (46%), Gaps = 18/193 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGI 162
+ LV G AG V+ T PL + +++ ++ +N GI+ F Q+IR+ G
Sbjct: 208 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASR--------SNNMGIVGGFTQMIREGGA 259
Query: 163 SALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTY 221
+LW G ++L + AI+FM YE +KR + + L + + G++A AIA + Y
Sbjct: 260 RSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIY 319
Query: 222 PLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTA 281
P++ +++ + R G +L + + R G+ YKG +L + A
Sbjct: 320 PMEVLKTRMAL---------RKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYA 370
Query: 282 ALMFLVYEKLTAA 294
+ VYE L A
Sbjct: 371 GIDLAVYETLKNA 383
Score = 30.0 bits (66), Expect = 2.7
Identities = 22/100 (22%), Positives = 42/100 (42%), Gaps = 8/100 (8%)
Query: 207 IIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGL 266
+ G A A++ T T PL ++ +++ R N G Q +R G L
Sbjct: 211 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG--------FTQMIREGGARSL 262
Query: 267 YKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKRAHQ 306
++G +L+ +A+ F+ YE++ + R H+
Sbjct: 263 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHE 302
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 75.5 bits (184), Expect = 6e-14
Identities = 72/289 (24%), Positives = 130/289 (44%), Gaps = 26/289 (8%)
Query: 12 HAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMV-LLEIIKEEGLLAPYRGWFP 70
H VAG + T PLD ++ +QV R + + ++I+E G + +RG
Sbjct: 189 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 248
Query: 71 VISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKD-LVVGFVAGVVNVLLTTPLWVVNTRL 129
+ + + + F + +K L Q + + LV G +AG + P+ V+ TR+
Sbjct: 249 NVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 308
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFYEG 188
L+ Y G++D +I+ EG++A + G P++L + A I YE
Sbjct: 309 ALRKTG---------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET 359
Query: 189 LKRQLLKKRMKLSSLD--VFII---GAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRT 243
LK L+ ++S D VF++ G ++ +YPL V++ ++ T
Sbjct: 360 LKNAWLQ-HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT 418
Query: 244 LGSL-RNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ SL ++IL R G GLY+GL ++ + ++ ++VYE L
Sbjct: 419 MSSLFKHIL-------RTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 460
Score = 67.4 bits (163), Expect = 2e-11
Identities = 52/193 (26%), Positives = 90/193 (46%), Gaps = 18/193 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGI 162
+ LV G AG V+ T PL + +++ ++ +N GI+ F Q+IR+ G
Sbjct: 188 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASR--------SNNMGIVGGFTQMIREGGA 239
Query: 163 SALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTY 221
+LW G ++L + AI+FM YE +KR + + L + + G++A AIA + Y
Sbjct: 240 RSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIY 299
Query: 222 PLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTA 281
P++ +++ + R G +L + + R G+ YKG +L + A
Sbjct: 300 PMEVLKTRMAL---------RKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYA 350
Query: 282 ALMFLVYEKLTAA 294
+ VYE L A
Sbjct: 351 GIDLAVYETLKNA 363
Score = 30.0 bits (66), Expect = 2.7
Identities = 22/100 (22%), Positives = 42/100 (42%), Gaps = 8/100 (8%)
Query: 207 IIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGL 266
+ G A A++ T T PL ++ +++ R N G Q +R G L
Sbjct: 191 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG--------FTQMIREGGARSL 242
Query: 267 YKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKRAHQ 306
++G +L+ +A+ F+ YE++ + R H+
Sbjct: 243 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHE 282
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 75.5 bits (184), Expect = 6e-14
Identities = 72/289 (24%), Positives = 130/289 (44%), Gaps = 26/289 (8%)
Query: 12 HAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMV-LLEIIKEEGLLAPYRGWFP 70
H VAG + T PLD ++ +QV R + + ++I+E G + +RG
Sbjct: 86 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 145
Query: 71 VISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKD-LVVGFVAGVVNVLLTTPLWVVNTRL 129
+ + + + F + +K L Q + + LV G +AG + P+ V+ TR+
Sbjct: 146 NVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 205
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFYEG 188
L+ Y G++D +I+ EG++A + G P++L + A I YE
Sbjct: 206 ALRKTG---------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET 256
Query: 189 LKRQLLKKRMKLSSLD--VFII---GAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRT 243
LK L+ ++S D VF++ G ++ +YPL V++ ++ T
Sbjct: 257 LKNAWLQ-HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT 315
Query: 244 LGSL-RNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ SL ++IL R G GLY+GL ++ + ++ ++VYE L
Sbjct: 316 MSSLFKHIL-------RTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 357
Score = 67.4 bits (163), Expect = 2e-11
Identities = 52/193 (26%), Positives = 90/193 (46%), Gaps = 18/193 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGI 162
+ LV G AG V+ T PL + +++ ++ +N GI+ F Q+IR+ G
Sbjct: 85 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASR--------SNNMGIVGGFTQMIREGGA 136
Query: 163 SALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTY 221
+LW G ++L + AI+FM YE +KR + + L + + G++A AIA + Y
Sbjct: 137 RSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIY 196
Query: 222 PLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTA 281
P++ +++ + R G +L + + R G+ YKG +L + A
Sbjct: 197 PMEVLKTRMAL---------RKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYA 247
Query: 282 ALMFLVYEKLTAA 294
+ VYE L A
Sbjct: 248 GIDLAVYETLKNA 260
Score = 30.0 bits (66), Expect = 2.7
Identities = 22/100 (22%), Positives = 42/100 (42%), Gaps = 8/100 (8%)
Query: 207 IIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGL 266
+ G A A++ T T PL ++ +++ R N G Q +R G L
Sbjct: 88 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG--------FTQMIREGGARSL 139
Query: 267 YKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKRAHQ 306
++G +L+ +A+ F+ YE++ + R H+
Sbjct: 140 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHE 179
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 75.5 bits (184), Expect = 6e-14
Identities = 72/289 (24%), Positives = 130/289 (44%), Gaps = 26/289 (8%)
Query: 12 HAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMV-LLEIIKEEGLLAPYRGWFP 70
H VAG + T PLD ++ +QV R + + ++I+E G + +RG
Sbjct: 223 HLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGI 282
Query: 71 VISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKD-LVVGFVAGVVNVLLTTPLWVVNTRL 129
+ + + + F + +K L Q + + LV G +AG + P+ V+ TR+
Sbjct: 283 NVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRM 342
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFYEG 188
L+ Y G++D +I+ EG++A + G P++L + A I YE
Sbjct: 343 ALRKTG---------QYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET 393
Query: 189 LKRQLLKKRMKLSSLD--VFII---GAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRT 243
LK L+ ++S D VF++ G ++ +YPL V++ ++ T
Sbjct: 394 LKNAWLQ-HYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVT 452
Query: 244 LGSL-RNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ SL ++IL R G GLY+GL ++ + ++ ++VYE L
Sbjct: 453 MSSLFKHIL-------RTEGAFGLYRGLAPNFMKVIPAVSISYVVYENL 494
Score = 67.4 bits (163), Expect = 2e-11
Identities = 52/193 (26%), Positives = 90/193 (46%), Gaps = 18/193 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGI 162
+ LV G AG V+ T PL + +++ ++ +N GI+ F Q+IR+ G
Sbjct: 222 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASR--------SNNMGIVGGFTQMIREGGA 273
Query: 163 SALWNGTFPSLLLVF-NPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTY 221
+LW G ++L + AI+FM YE +KR + + L + + G++A AIA + Y
Sbjct: 274 RSLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIY 333
Query: 222 PLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTA 281
P++ +++ + R G +L + + R G+ YKG +L + A
Sbjct: 334 PMEVLKTRMAL---------RKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYA 384
Query: 282 ALMFLVYEKLTAA 294
+ VYE L A
Sbjct: 385 GIDLAVYETLKNA 397
Score = 30.0 bits (66), Expect = 2.7
Identities = 22/100 (22%), Positives = 42/100 (42%), Gaps = 8/100 (8%)
Query: 207 IIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGL 266
+ G A A++ T T PL ++ +++ R N G Q +R G L
Sbjct: 225 VAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGG--------FTQMIREGGARSL 276
Query: 267 YKGLEAKLLQTVLTAALMFLVYEKLTAATFTVMGLKRAHQ 306
++G +L+ +A+ F+ YE++ + R H+
Sbjct: 277 WRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHE 316
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 74.7 bits (182), Expect = 1e-13
Identities = 69/289 (23%), Positives = 124/289 (42%), Gaps = 24/289 (8%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVD--------EKRKSKTTHMVLLEIIKEEGLLAPY 65
V G + S+ A FP+D + RLQV ++ K + L I KEEG+LA Y
Sbjct: 45 VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALY 104
Query: 66 RGWFPVISSLCCSNFVYFYTFNSLKALWVKG-QHSTTGKDLVVGFVAGVVNVLLTTPLWV 124
G P + + + SLK L+V+ + T +++ G V+GV++ + P V
Sbjct: 105 SGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDV 164
Query: 125 VNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSL-LLVFNPAIQF 183
+ R++ QG+ F+ +I +F I + EG LW G P+ ++
Sbjct: 165 LKIRMQAQGSLFQG---------SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVEL 215
Query: 184 MFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIA-TTVTYPLQTVQSILRFGRHRLNPENR 242
Y+ K+ L+ M ++ + + +A + P+ V++ + R + +
Sbjct: 216 PVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDL 275
Query: 243 TLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
G++ IL + + G LYKG L+ + F+ YE+L
Sbjct: 276 YKGTVDGILKMW----KHEGFFALYKGFWPNWLRLGPWNIIFFITYEQL 320
Score = 58.2 bits (139), Expect = 9e-09
Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 9/186 (4%)
Query: 10 LVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWF 69
L++ + G V V + T+ P D ++R+Q + ++I ++EG +RG
Sbjct: 142 LINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVV 201
Query: 70 PVISSLCCSNFVYFYTFN-SLKALWVKG-QHSTTGKDLVVGFVAGVVNVLLTTPLWVVNT 127
P V ++ + K L + G T V F G+ L + P+ VV T
Sbjct: 202 PTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRT 261
Query: 128 RLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLV--FNPAIQFMF 185
R+ Q A + D+ YKG +D ++ + EG AL+ G +P+ L + +N I F+
Sbjct: 262 RMMNQRAIVGHVDL----YKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWN-IIFFIT 316
Query: 186 YEGLKR 191
YE LKR
Sbjct: 317 YEQLKR 322
Score = 55.5 bits (132), Expect = 6e-08
Identities = 48/192 (25%), Positives = 91/192 (47%), Gaps = 19/192 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQG----AKFRNEDIVPTNYKGIIDAFHQIIR 158
K V G +A +V T P+ + TRL++QG A+F+ Y+G+ A +I +
Sbjct: 42 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKE-----IKYRGMFHALFRICK 96
Query: 159 DEGISALWNGTFPSLLLVFN-PAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIAT 217
+EG+ AL++G P+LL + I+ Y+ LKR +++ + L I G V+ I++
Sbjct: 97 EEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISS 156
Query: 218 TVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQT 277
T+ P ++ +R + +GS +I ++ G GL++G+ +
Sbjct: 157 TIANPTDVLK--IRMQAQGSLFQGSMIGSFIDI-------YQQEGTRGLWRGVVPTAQRA 207
Query: 278 VLTAALMFLVYE 289
+ + VY+
Sbjct: 208 AIVVGVELPVYD 219
Score = 34.3 bits (77), Expect = 0.14
Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 5/90 (5%)
Query: 10 LVHAVAGAVGSVTAMTVFFPLDTARLRLQ-----VDEKRKSKTTHMVLLEIIKEEGLLAP 64
L H V+ + P+D R R+ V K T +L++ K EG A
Sbjct: 236 LTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFAL 295
Query: 65 YRGWFPVISSLCCSNFVYFYTFNSLKALWV 94
Y+G++P L N ++F T+ LK L +
Sbjct: 296 YKGFWPNWLRLGPWNIIFFITYEQLKRLQI 325
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 74.7 bits (182), Expect = 1e-13
Identities = 69/289 (23%), Positives = 124/289 (42%), Gaps = 24/289 (8%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVD--------EKRKSKTTHMVLLEIIKEEGLLAPY 65
V G + S+ A FP+D + RLQV ++ K + L I KEEG+LA Y
Sbjct: 42 VYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALY 101
Query: 66 RGWFPVISSLCCSNFVYFYTFNSLKALWVKG-QHSTTGKDLVVGFVAGVVNVLLTTPLWV 124
G P + + + SLK L+V+ + T +++ G V+GV++ + P V
Sbjct: 102 SGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDV 161
Query: 125 VNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSL-LLVFNPAIQF 183
+ R++ QG+ F+ +I +F I + EG LW G P+ ++
Sbjct: 162 LKIRMQAQGSLFQG---------SMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVEL 212
Query: 184 MFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIA-TTVTYPLQTVQSILRFGRHRLNPENR 242
Y+ K+ L+ M ++ + + +A + P+ V++ + R + +
Sbjct: 213 PVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDL 272
Query: 243 TLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
G++ IL + + G LYKG L+ + F+ YE+L
Sbjct: 273 YKGTVDGILKMW----KHEGFFALYKGFWPNWLRLGPWNIIFFITYEQL 317
Score = 58.2 bits (139), Expect = 9e-09
Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 9/186 (4%)
Query: 10 LVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWF 69
L++ + G V V + T+ P D ++R+Q + ++I ++EG +RG
Sbjct: 139 LINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVV 198
Query: 70 PVISSLCCSNFVYFYTFN-SLKALWVKG-QHSTTGKDLVVGFVAGVVNVLLTTPLWVVNT 127
P V ++ + K L + G T V F G+ L + P+ VV T
Sbjct: 199 PTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRT 258
Query: 128 RLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLV--FNPAIQFMF 185
R+ Q A + D+ YKG +D ++ + EG AL+ G +P+ L + +N I F+
Sbjct: 259 RMMNQRAIVGHVDL----YKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWN-IIFFIT 313
Query: 186 YEGLKR 191
YE LKR
Sbjct: 314 YEQLKR 319
Score = 55.5 bits (132), Expect = 6e-08
Identities = 48/192 (25%), Positives = 91/192 (47%), Gaps = 19/192 (9%)
Query: 103 KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQG----AKFRNEDIVPTNYKGIIDAFHQIIR 158
K V G +A +V T P+ + TRL++QG A+F+ Y+G+ A +I +
Sbjct: 39 KPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKE-----IKYRGMFHALFRICK 93
Query: 159 DEGISALWNGTFPSLLLVFN-PAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIAT 217
+EG+ AL++G P+LL + I+ Y+ LKR +++ + L I G V+ I++
Sbjct: 94 EEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISS 153
Query: 218 TVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQT 277
T+ P ++ +R + +GS +I ++ G GL++G+ +
Sbjct: 154 TIANPTDVLK--IRMQAQGSLFQGSMIGSFIDI-------YQQEGTRGLWRGVVPTAQRA 204
Query: 278 VLTAALMFLVYE 289
+ + VY+
Sbjct: 205 AIVVGVELPVYD 216
Score = 34.3 bits (77), Expect = 0.14
Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 5/90 (5%)
Query: 10 LVHAVAGAVGSVTAMTVFFPLDTARLRLQ-----VDEKRKSKTTHMVLLEIIKEEGLLAP 64
L H V+ + P+D R R+ V K T +L++ K EG A
Sbjct: 233 LTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFAL 292
Query: 65 YRGWFPVISSLCCSNFVYFYTFNSLKALWV 94
Y+G++P L N ++F T+ LK L +
Sbjct: 293 YKGFWPNWLRLGPWNIIFFITYEQLKRLQI 322
>gi|149274643 solute carrier family 25, member 28 [Homo sapiens]
Length = 364
Score = 73.9 bits (180), Expect = 2e-13
Identities = 72/286 (25%), Positives = 119/286 (41%), Gaps = 21/286 (7%)
Query: 12 HAVAGAVGSVTAMTVFFPLDTARLR---LQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGW 68
H VAGAV + V +P+D + R LQ D + + L II+ EGL P RG
Sbjct: 75 HMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGL 134
Query: 69 FPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLL----TTPLWV 124
+ ++ +YF + LK H G + AG V LL P V
Sbjct: 135 NVTATGAGPAHALYFACYEKLKKTLSDVIH-PGGNSHIANGAAGCVATLLHDAAMNPAEV 193
Query: 125 VNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLL-VFNPAIQF 183
V R+++ + Y + D + ++EG A + L + V AI F
Sbjct: 194 VKQRMQMYNSP----------YHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHF 243
Query: 184 MFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRT 243
M YE L+ +R S V + GA A A+A T PL +++L + L +
Sbjct: 244 MTYEFLQEHFNPQRRYNPSSHV-LSGACAGAVAAAATTPLDVCKTLLN-TQESLALNSHI 301
Query: 244 LGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYE 289
G + + + G+ ++G++A+++ + + A+ + VYE
Sbjct: 302 TGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYE 347
Score = 45.4 bits (106), Expect = 6e-05
Identities = 42/189 (22%), Positives = 80/189 (42%), Gaps = 3/189 (1%)
Query: 10 LVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWF 69
+ + AG V ++ P + + R+Q+ + T V + + EG A YR +
Sbjct: 171 IANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRA-VWQNEGAGAFYRSYT 229
Query: 70 PVISSLCCSNFVYFYTFNSLKALWVKGQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRL 129
++ ++F T+ L+ + + ++ G AG V TTPL V T L
Sbjct: 230 TQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLL 289
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLL-VFNPAIQFMFYEG 188
Q + N I + G+ AF + + G++A + G ++ + + AI + YE
Sbjct: 290 NTQESLALNSHIT-GHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEF 348
Query: 189 LKRQLLKKR 197
K + K++
Sbjct: 349 FKYLITKRQ 357
Score = 31.6 bits (70), Expect = 0.92
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 6/85 (7%)
Query: 207 IIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGL 266
+ GAVA + V YP+ V++ ++ L P+ RN+L L + +R G+
Sbjct: 77 VAGAVAGILEHCVMYPIDCVKTRMQ----SLQPD--PAARYRNVLEALWRIIRTEGLWRP 130
Query: 267 YKGLEAKLLQTVLTAALMFLVYEKL 291
+GL AL F YEKL
Sbjct: 131 MRGLNVTATGAGPAHALYFACYEKL 155
Score = 31.2 bits (69), Expect = 1.2
Identities = 44/202 (21%), Positives = 79/202 (39%), Gaps = 31/202 (15%)
Query: 99 STTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIR 158
+T +V G VAG++ + P+ V TR++ + Y+ +++A +IIR
Sbjct: 70 ATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQ------SLQPDPAARYRNVLEALWRIIR 123
Query: 159 DE-------GISALWNGTFPSLLLVFNPAIQFMFYEGLKRQL--LKKRMKLSSLDVFIIG 209
E G++ G P+ A+ F YE LK+ L + S + G
Sbjct: 124 TEGLWRPMRGLNVTATGAGPA------HALYFACYEKLKKTLSDVIHPGGNSHIANGAAG 177
Query: 210 AVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKG 269
VA + P + V+ ++ +P +R +R + + G Y+
Sbjct: 178 CVATLLHDAAMNPAEVVKQRMQMYN---SPYHRVTDCVRAVW-------QNEGAGAFYRS 227
Query: 270 LEAKLLQTVLTAALMFLVYEKL 291
+L V A+ F+ YE L
Sbjct: 228 YTTQLTMNVPFQAIHFMTYEFL 249
>gi|60460887 solute carrier family 25, member 42 [Homo sapiens]
Length = 318
Score = 72.8 bits (177), Expect = 4e-13
Identities = 75/284 (26%), Positives = 114/284 (40%), Gaps = 26/284 (9%)
Query: 16 GAVGSVTAMTVFFPLDTARLRLQVDEKR-KSKTTHMVLLEIIKEEGLLAPYRGWFPVISS 74
GA+ A T PLD ++ QV KR +K VL EG L+ +RG +
Sbjct: 40 GALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLNEGFLSLWRGNSATMVR 99
Query: 75 LCCSNFVYFYTFNSLKAL-----WVKGQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRL 129
+ + F K + +G+ L G +AG LT PL +V R+
Sbjct: 100 VVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAASLTYPLDLVRARM 159
Query: 130 KLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA-IQFMFYEG 188
+ + Y I F +I R+EG+ L++G P++L V A + F YE
Sbjct: 160 AVTPKEM---------YSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPYAGLSFFTYET 210
Query: 189 LK--RQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGS 246
LK + R + + I GA A I + +YPL V R R+ T
Sbjct: 211 LKSLHREYSGRRQPYPFERMIFGACAGLIGQSASYPLDVV-------RRRMQTAGVTGYP 263
Query: 247 LRNILYLLHQRVRRFG-IMGLYKGLEAKLLQTVLTAALMFLVYE 289
+I L VR G + GLYKGL ++ + + F ++
Sbjct: 264 RASIARTLRTIVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFD 307
Score = 58.9 bits (141), Expect = 5e-09
Identities = 44/160 (27%), Positives = 73/160 (45%), Gaps = 15/160 (9%)
Query: 15 AGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWFPVISS 74
AGA+ TA ++ +PLD R R+ V K V + I +EEGL Y G+ P +
Sbjct: 137 AGALAGTTAASLTYPLDLVRARMAVTPKEMYSNIFHVFIRISREEGLKTLYHGFMPTVLG 196
Query: 75 LCCSNFVYFYTFNSLKAL---WVKGQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKL 131
+ + F+T+ +LK+L + + + ++ G AG++ + PL VV R++
Sbjct: 197 VIPYAGLSFFTYETLKSLHREYSGRRQPYPFERMIFGACAGLIGQSASYPLDVVRRRMQT 256
Query: 132 QGAKFRNEDIVPTNY--KGIIDAFHQIIRDEG-ISALWNG 168
G T Y I I+R+EG + L+ G
Sbjct: 257 AGV---------TGYPRASIARTLRTIVREEGAVRGLYKG 287
Score = 45.1 bits (105), Expect = 8e-05
Identities = 50/202 (24%), Positives = 79/202 (39%), Gaps = 22/202 (10%)
Query: 95 KGQHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFH 154
K H L+ G +AG + PL ++ +F ++ Y ++
Sbjct: 27 KRDHRQVLSSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLN--- 83
Query: 155 QIIRDEGISALWNGTFPSLLLVFN-PAIQFMFYEGLKRQLLK----KRMKLSSLDVFIIG 209
EG +LW G +++ V AIQF +E KR L + L G
Sbjct: 84 -----EGFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAG 138
Query: 210 AVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKG 269
A+A A ++TYPL V++ R + P+ NI ++ + R G+ LY G
Sbjct: 139 ALAGTTAASLTYPLDLVRA-----RMAVTPKEM----YSNIFHVFIRISREEGLKTLYHG 189
Query: 270 LEAKLLQTVLTAALMFLVYEKL 291
+L + A L F YE L
Sbjct: 190 FMPTVLGVIPYAGLSFFTYETL 211
Score = 33.5 bits (75), Expect = 0.24
Identities = 25/102 (24%), Positives = 43/102 (42%), Gaps = 8/102 (7%)
Query: 189 LKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLR 248
L + KR L + GA+A A+A T PL + I + R S +
Sbjct: 20 LSSSVSSKRDHRQVLSSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRF--------SAK 71
Query: 249 NILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEK 290
+L+ G + L++G A +++ V AA+ F +E+
Sbjct: 72 EAFRVLYYTYLNEGFLSLWRGNSATMVRVVPYAAIQFSAHEE 113
>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
Length = 370
Score = 72.0 bits (175), Expect = 6e-13
Identities = 68/281 (24%), Positives = 128/281 (45%), Gaps = 16/281 (5%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLE-IIKEEGLLAPYRGWFPVI 72
++GA+ + T PLD A++ +QV + + T + L+ +++E G + +RG +
Sbjct: 97 LSGAMAGAVSRTGTAPLDRAKVYMQVYSSKTNFTNLLGGLQSMVQEGGFRSLWRGNGINV 156
Query: 73 SSLCCSNFVYFYTFNSLKALWVKGQHSTTGKD-LVVGFVAGVVNVLLTTPLWVVNTRLKL 131
+ + F F K + Q S ++ L+ G +A ++ L P+ V+ TRL L
Sbjct: 157 LKIAPEYAIKFSVFEQCKNYFCGIQGSPPFQERLLAGSLAVAISQTLINPMEVLKTRLTL 216
Query: 132 QGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLL-LVFNPAIQFMFYEGLK 190
+ YKG++D QI++ EG AL+ G P++L ++ YE L+
Sbjct: 217 RRTG---------QYKGLLDCARQILQREGTRALYRGYLPNMLGIIPYACTDLAVYEMLQ 267
Query: 191 RQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNI 250
+K + G V+ + T T Q L R R+ ++ GS +
Sbjct: 268 CFWVKSGRDMGDPS----GLVSLSSVTLSTTCGQMASYPLTLVRTRMQAQDTVEGSNPTM 323
Query: 251 LYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+L + + + G +GLY+G+ LL+ + + ++VYE +
Sbjct: 324 RGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAM 364
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 71.6 bits (174), Expect = 8e-13
Identities = 67/258 (25%), Positives = 116/258 (44%), Gaps = 26/258 (10%)
Query: 26 VFFPLDTARLRLQVD-EKRKSKTTHMV--------LLEIIKEEGLLAPYRGWFPVISSLC 76
V FPLDTA++RLQ+ E + +T +V +L +++ EG +PY G +
Sbjct: 30 VTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQM 89
Query: 77 CSNFVYFYTFNSLKALWV-KG-QHSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGA 134
+ ++S+K ++ KG +S+ ++ G G + V P VV R Q +
Sbjct: 90 SFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRF--QAS 147
Query: 135 KFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLL--LVFNPAIQFMFYEGLKRQ 192
Y G +DA+ I R+EG+ LW GT P+++ + N A + + Y+ LK +
Sbjct: 148 IHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCA-EVVTYDILKEK 206
Query: 193 LLKKRMKLSSLDVFIIGAV-AKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNIL 251
LL + + + A A AT V P+ V++ R+ +P + L ++
Sbjct: 207 LLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKT-----RYMNSPPGQYFSPLDCMI 261
Query: 252 YLLHQRVRRFGIMGLYKG 269
++ Q G YKG
Sbjct: 262 KMVAQE----GPTAFYKG 275
Score = 47.0 bits (110), Expect = 2e-05
Identities = 44/182 (24%), Positives = 78/182 (42%), Gaps = 14/182 (7%)
Query: 117 LLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLV 176
L+T PL RL++QG + Y+G++ ++R EG + +NG L
Sbjct: 29 LVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQ 88
Query: 177 FN-PAIQFMFYEGLKRQLLKKRMKLSSLDVFII-GAVAKAIATTVTYPLQTV----QSIL 230
+ +I+ Y+ +K+ K SSL I+ G A+A T P V Q+ +
Sbjct: 89 MSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASI 148
Query: 231 RFGRHRLNPE-NRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYE 289
G R + + + T+ + R I R G+ GL+KG +++ + + Y+
Sbjct: 149 HLGPSRSDRKYSGTMDAYRTI-------AREEGVRGLWKGTLPNIMRNAIVNCAEVVTYD 201
Query: 290 KL 291
L
Sbjct: 202 IL 203
Score = 30.0 bits (66), Expect = 2.7
Identities = 22/86 (25%), Positives = 36/86 (41%)
Query: 206 FIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMG 265
F+ A A VT+PL T + L+ + L R +L + VR G
Sbjct: 17 FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76
Query: 266 LYKGLEAKLLQTVLTAALMFLVYEKL 291
Y GL A L + + A++ +Y+ +
Sbjct: 77 PYNGLVAGLQRQMSFASIRIGLYDSV 102
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 70.1 bits (170), Expect = 2e-12
Identities = 65/291 (22%), Positives = 124/291 (42%), Gaps = 23/291 (7%)
Query: 11 VHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHM------VLLEIIKEEGLLAP 64
V + + + A + FPLDTA++RLQV + + + + ++K EG +
Sbjct: 15 VQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKL 74
Query: 65 YRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHS--TTGKDLVVGFVAGVVNVLLTTPL 122
Y G + S + +++++ G+ + + G ++ G G V V + P
Sbjct: 75 YSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPT 134
Query: 123 WVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLL-LVFNPAI 181
VV RL+ Q + Y G +A+ I EG++ LW GT P+L+ V
Sbjct: 135 EVVKVRLQAQSHLHG----IKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCT 190
Query: 182 QFMFYEGLKRQLLKKRMKLSSLDVFIIGA-VAKAIATTVTYPLQTVQSILRFGRHRLNPE 240
+ + Y+ +K +K + + ++ A +A AT ++ P+ V++ RF
Sbjct: 191 ELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKT--RF-------I 241
Query: 241 NRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
N G +++ + G +KGL L+ +MF+ +E+L
Sbjct: 242 NSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQL 292
Score = 44.7 bits (104), Expect = 1e-04
Identities = 43/199 (21%), Positives = 84/199 (42%), Gaps = 9/199 (4%)
Query: 98 HSTTGKDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQII 157
H T G L +A + ++T PL RL++QG + I YKG++ ++
Sbjct: 10 HPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVI---RYKGVLGTITAVV 66
Query: 158 RDEGISALWNGTFPSL-LLVFNPAIQFMFYEGLKRQLLKKRMKLSSLDVFII-GAVAKAI 215
+ EG L++G L + + +++ Y+ ++ L + SL I+ G +
Sbjct: 67 KTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGV 126
Query: 216 ATTVTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLL 275
A + P + V+ L+ H + R G+ + G+ GL+KG L+
Sbjct: 127 AVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTE----GLTGLWKGTTPNLM 182
Query: 276 QTVLTAALMFLVYEKLTAA 294
++V+ + Y+ + A
Sbjct: 183 RSVIINCTELVTYDLMKEA 201
Score = 30.8 bits (68), Expect = 1.6
Identities = 19/88 (21%), Positives = 36/88 (40%)
Query: 3 SVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLL 62
++L+ + H V+ + A + P+D + R + K+ +++ EG
Sbjct: 206 NILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPT 265
Query: 63 APYRGWFPVISSLCCSNFVYFYTFNSLK 90
A ++G P L N + F F LK
Sbjct: 266 AFFKGLVPSFLRLGSWNVIMFVCFEQLK 293
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 70.1 bits (170), Expect = 2e-12
Identities = 67/287 (23%), Positives = 113/287 (39%), Gaps = 19/287 (6%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKTTHMVLLEIIKEEGLLAPYRGWFPVIS 73
VAG + + + P DT ++RLQ + MV +I + E LL ++G I+
Sbjct: 7 VAGWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDCMV--KIYRHESLLGFFKGMSFPIA 64
Query: 74 SLCCSNFVYFYTFNSLKALWVKGQHSTTGKD-------LVVGFVAGVVNVLLTTPLWVVN 126
S+ N V F +++ + H + G G + P ++
Sbjct: 65 SIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIK 124
Query: 127 TRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNGTFPSLLLVFNPA--IQFM 184
RL+ Q P Y+G + I R+EG L+ G + +L L P I F+
Sbjct: 125 VRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAW-ALTLRDTPTVGIYFI 183
Query: 185 FYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATTVTYPLQTVQSILRFGRHRLNPENRTL 244
YEGL RQ + SS V + G A + PL ++S R+ +
Sbjct: 184 TYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKS-------RMQMDGLRR 236
Query: 245 GSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQTVLTAALMFLVYEKL 291
+ +L + +R+ G+ ++G+ + A+ FL YE L
Sbjct: 237 RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 283
Score = 54.3 bits (129), Expect = 1e-07
Identities = 48/190 (25%), Positives = 84/190 (44%), Gaps = 20/190 (10%)
Query: 14 VAGAVGSVTAMTVFFPLDTARLRLQVDEKRKSKT----------THMVLLEIIKEEGLLA 63
+AG G P D ++RLQ + +++ H I +EEG
Sbjct: 104 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAA-SIFREEGPRG 162
Query: 64 PYRGWFPVISSLCCSNFVYFYTFNSLKALWV-KGQHSTTGKDLVVGFVAGVVNVLLTTPL 122
+RG + + + +YF T+ L + +GQ+ ++ LV G AG+ + + TPL
Sbjct: 163 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 222
Query: 123 WVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDEGISALWNG-TFPSLLLVFNPAI 181
++ +R+++ G + R Y+G++D IR EG+ + G T S A+
Sbjct: 223 DMIKSRMQMDGLRRR-------VYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAV 275
Query: 182 QFMFYEGLKR 191
F+ YE L R
Sbjct: 276 TFLSYEYLLR 285
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.139 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,484,526
Number of Sequences: 37866
Number of extensions: 365536
Number of successful extensions: 1371
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 901
Number of HSP's gapped (non-prelim): 203
length of query: 307
length of database: 18,247,518
effective HSP length: 102
effective length of query: 205
effective length of database: 14,385,186
effective search space: 2948963130
effective search space used: 2948963130
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.