Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 50959205
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50959205 adenylate cyclase 9 [Homo sapiens]
(1353 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50959205 adenylate cyclase 9 [Homo sapiens] 2725 0.0
gi|24497587 adenylate cyclase 4 [Homo sapiens] 393 e-109
gi|148536830 adenylate cyclase 3 [Homo sapiens] 380 e-105
gi|115387102 adenylate cyclase 2 [Homo sapiens] 225 2e-58
gi|4557257 adenylate cyclase 8 [Homo sapiens] 221 4e-57
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 216 9e-56
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 216 9e-56
gi|34486092 adenylate cyclase 5 [Homo sapiens] 215 3e-55
gi|31083193 adenylate cyclase 1 [Homo sapiens] 211 5e-54
gi|4557255 adenylate cyclase 7 [Homo sapiens] 202 2e-51
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 111 4e-24
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 107 1e-22
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 105 2e-22
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 101 6e-21
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 101 6e-21
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 101 6e-21
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 101 6e-21
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 101 6e-21
gi|134152694 guanylate cyclase 2F [Homo sapiens] 100 7e-21
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 99 3e-20
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 98 5e-20
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 98 5e-20
gi|222080083 guanylate cyclase 2C [Homo sapiens] 94 9e-19
gi|209976994 adenylate cyclase 10 [Homo sapiens] 35 0.49
gi|7657307 LIM domains containing 1 [Homo sapiens] 34 1.1
gi|24797143 sorting nexin 14 isoform b [Homo sapiens] 33 1.9
gi|24797145 sorting nexin 14 isoform a [Homo sapiens] 33 1.9
gi|53828698 olfactory receptor, family 13, subfamily G, member 1... 32 4.1
gi|55956788 nucleolin [Homo sapiens] 32 5.4
gi|212549782 caspase 8 associated protein 2 [Homo sapiens] 31 7.1
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 2725 bits (7063), Expect = 0.0
Identities = 1353/1353 (100%), Positives = 1353/1353 (100%)
Query: 1 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS 60
MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS
Sbjct: 1 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDS 60
Query: 61 GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL 120
GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL
Sbjct: 61 GGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYAL 120
Query: 121 FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT 180
FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT
Sbjct: 121 FYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT 180
Query: 181 LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL 240
LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL
Sbjct: 181 LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHL 240
Query: 241 PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV 300
PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV
Sbjct: 241 PLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFV 300
Query: 301 MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR 360
MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR
Sbjct: 301 MSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR 360
Query: 361 HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN 420
HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN
Sbjct: 361 HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN 420
Query: 421 DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK 480
DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK
Sbjct: 421 DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK 480
Query: 481 KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD 540
KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD
Sbjct: 481 KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD 540
Query: 541 DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS 600
DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS
Sbjct: 541 DRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVS 600
Query: 601 SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN 660
SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN
Sbjct: 601 SGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKN 660
Query: 661 STKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI 720
STKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI
Sbjct: 661 STKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNI 720
Query: 721 REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF 780
REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF
Sbjct: 721 REKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTF 780
Query: 781 ASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIR 840
ASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIR
Sbjct: 781 ASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIR 840
Query: 841 MVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGS 900
MVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGS
Sbjct: 841 MVFFLEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGS 900
Query: 901 AALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSER 960
AALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSER
Sbjct: 901 AALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSER 960
Query: 961 NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTK 1020
NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTK
Sbjct: 961 NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTK 1020
Query: 1021 IQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKE 1080
IQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKE
Sbjct: 1021 IQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKE 1080
Query: 1081 CYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFE 1140
CYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFE
Sbjct: 1081 CYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFE 1140
Query: 1141 FAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTT 1200
FAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTT
Sbjct: 1141 FAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTT 1200
Query: 1201 GVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISP 1260
GVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISP
Sbjct: 1201 GVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTDHRVIPQHQLSISP 1260
Query: 1261 DIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEE 1320
DIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEE
Sbjct: 1261 DIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEE 1320
Query: 1321 RGRFGKAIEKDDCDETGIEEANELTKLNVSKSV 1353
RGRFGKAIEKDDCDETGIEEANELTKLNVSKSV
Sbjct: 1321 RGRFGKAIEKDDCDETGIEEANELTKLNVSKSV 1353
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 393 bits (1010), Expect = e-109
Identities = 325/1005 (32%), Positives = 486/1005 (48%), Gaps = 153/1005 (15%)
Query: 276 ALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIH 335
AL +L + +L C + GV+ + + R+TF + S+ + L+ EK +E ++
Sbjct: 169 ALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLL 228
Query: 336 SVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSI 395
S++P +A ++ ++E + A + + F +++ + VS+
Sbjct: 229 SILPAYLAREM------KAEIMARLQAGQGSRPESTNN--------FHSLYVKRHQGVSV 274
Query: 396 LFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPR 455
L+ADIVGFT++++ S LV +LN+LFG+FD++ +E +C +I LGDCYYCV+G P
Sbjct: 275 LYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSL 334
Query: 456 ADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVN 515
DHA C+ MGL M +AI + +NMRVGVH+G+VLCG++G++++++DVWS+DV
Sbjct: 335 PDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVT 394
Query: 516 LANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQR 575
LAN ME GV G+VHI+ AT L Y +ED + R +L G TYL+ R
Sbjct: 395 LANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHR---DPYLREL-GEPTYLVIDPR 450
Query: 576 AKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGI 635
A+E +GTA + + + LK PS +
Sbjct: 451 AEEED------------------------EKGTAGG--------LLSSLEGLKMRPSLLM 478
Query: 636 TFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEI 695
T +S A K S G +P + + +P E+ L + T
Sbjct: 479 TRYLESWGAA-------------KPFAHLSHGDSPVSTS---TPLPEKTLASFST----- 517
Query: 696 LQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFL 755
+W SLD+S P + + DA F VI++ + K + N +L F
Sbjct: 518 -----QW---SLDRSRT-PRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFR 568
Query: 756 DQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVP 815
++E+E+ YR S K + + TF VFLS + L T
Sbjct: 569 EKEMEKEYRLS------AIPAFKYYEACTFL----VFLSNFIIQMLVTN----------- 607
Query: 816 PPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACT---KRLLEWI---AGWLP----- 864
PPA +S LL +L L V F ED+M C ++L W+ +G +
Sbjct: 608 RPPALAITYSITFLLFLLIL-----FVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGL 662
Query: 865 RHCIGAILVSLP-ALAVYSHVTSEYETNIHFPV-------------FTGSAALIAVVHYC 910
R +G + L A+A+ S ++ F GS LI+V +
Sbjct: 663 RIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSM 722
Query: 911 NFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSER---NPCNSSV 967
+ C L S + LLLL + L S+ + R P +S
Sbjct: 723 HCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSR- 781
Query: 968 PRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQ 1027
P L+ P L+G +FF LL+ L R+ E RL + + R + ++M +
Sbjct: 782 PGVLKEP-KLMGAISFFIFFFTLLV---LARQNEYYCRLDFLWKKKLRQEREETETMENL 837
Query: 1028 ADWLLRNIIPYHVAEQL-----KVSQTYSKNHDSGGVIFASIVNFSEFYEE---NYEGGK 1079
LL N++P HVA Q + Y ++++ V+FAS+ +F EFY E N+EG
Sbjct: 838 TRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEG-L 896
Query: 1080 ECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQE----HL 1135
EC R+LNE+I DFDELLSKP +S +EKIKTIG+TYMAA+GLN QD E HL
Sbjct: 897 ECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHL 956
Query: 1136 QILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIAS 1195
+ EFA + +D N + + NF+LRVG NHGP+ AGVIG K YDIWG+TVN+AS
Sbjct: 957 GTMVEFAVALGSKLDVINKHS-FNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVAS 1015
Query: 1196 RMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
RM++TGV +IQV+EE+ L +GY RG + VKGKGQ+ TY
Sbjct: 1016 RMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTY 1060
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 380 bits (975), Expect = e-105
Identities = 304/1011 (30%), Positives = 473/1011 (46%), Gaps = 168/1011 (16%)
Query: 280 ELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMP 339
E+L+ L+ C A+G+ + M+ + R FL+ QS+ +LE + +E ++ S++P
Sbjct: 225 EILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILP 284
Query: 340 RIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFAD 399
+ +AD+++K KK QK F M + E VSILFAD
Sbjct: 285 KHVADEMLKD--------------------MKKDESQKDQQQFNTMYMYRHENVSILFAD 324
Query: 400 IVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHA 459
IVGFT++S+ SA LV LLN+LF RFD+L + +I LGDCYYC+ G P+ R DHA
Sbjct: 325 IVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHA 384
Query: 460 YCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANL 519
C I MGL M++AI ++ K V+MRVGVHTGTVL G+LG +R+++DVWS DV +AN
Sbjct: 385 VCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANK 444
Query: 520 MEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQRAKES 579
ME G+ G+VHIS++T L +++E G R + KG++TYLI + +
Sbjct: 445 MEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYL----EEKGIETYLIIASKPEVK 500
Query: 580 RCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGITFAP 639
+ + L +GS + +G +SS P+ T P
Sbjct: 501 KTATQNGL-------NGSALPNGAPASSKSSS-------------------PALIETKEP 534
Query: 640 KSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEK 699
A + G + +E PNP+ + +
Sbjct: 535 NGSAHSSGSTSEK--PEEQDAQADNPSFPNPRRR-------------------LRLQDLA 573
Query: 700 GRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQEL 759
R S D+ L L + + E+ A V K ++ + S+ F+D E+
Sbjct: 574 DRVVDASEDEHELNQLLNEALLERESAQVVK--KRNTFL-----------LSMRFMDPEM 620
Query: 760 ERSYRTSYQEE---VIKNSPVKTFASPTFSSLLDVFLSTT--------VFLTLSTTCFLK 808
E Y +++ S V + L+D +L T + L + T C L
Sbjct: 621 ETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSL- 679
Query: 809 YEAATVPPP-PAALAVFSAAL------LLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAG 861
AA P P L FS + LA+ I ++ + D+++C L++ G
Sbjct: 680 --AAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSC----LQYYTG 733
Query: 862 WLPRHCIGAILVSLPALAVYSHVTSEYETN---IHFPVFTGSAALIAVVHYCNFCQLSSW 918
S+ T+ ET + P + A+++++ Q+S
Sbjct: 734 -------------------PSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHM 774
Query: 919 MRSSLATVV-GAGPLLLLYV----------SLCPDSSVLTSPLDAVQNFSSERNPCNSSV 967
++ +L +V GA + LY + + L+ +Q F+ N +
Sbjct: 775 VKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTD--- 831
Query: 968 PRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQ 1027
R P + ++ FL++L ++ +R E R + +E + ++ MR
Sbjct: 832 ----RLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRW 887
Query: 1028 ADWLLRNIIPYHVAEQL-----KVSQTYSKNHDSGGVIFASIVNFSEFYEEN--YEGGKE 1080
+ L+ N++P HVA + + YS+ +D GV+FAS+ NF++FY E GG E
Sbjct: 888 NEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIE 947
Query: 1081 CYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLN---------TAQAQDGSHP 1131
C R LNE+I DFD LL P + I KIKTIG+TYMAASG+ ++ +D S
Sbjct: 948 CLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSER 1007
Query: 1132 Q--EHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGD 1189
+ +HL L +FA M + + NN + NF LR+G N G + AGVIG K YDIWG+
Sbjct: 1008 ERWQHLADLADFALAMKDTLTNINNQS-FNNFMLRIGMNKGGVLAGVIGARKPHYDIWGN 1066
Query: 1190 TVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
TVN+ASRM++TGV IQV EE+ +L + G+ F RG + VKGKG++ T+
Sbjct: 1067 TVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTF 1117
Score = 71.6 bits (174), Expect = 5e-12
Identities = 56/250 (22%), Positives = 112/250 (44%), Gaps = 30/250 (12%)
Query: 980 QEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLH---RTKIQSMRDQADWLLRNII 1036
+E++ FL L + + ++ R H +EA + ++ Q + L+ +I+
Sbjct: 224 REILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSIL 283
Query: 1037 PYHVAEQL--------------KVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082
P HVA+++ + + Y H++ ++FA IV F++ + +E
Sbjct: 284 PKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQL--SSACSAQELV 341
Query: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142
++LNEL FD+L +K Y + +IK +G Y GL + ++H
Sbjct: 342 KLLNELFARFDKLAAK--YHQL-RIKILGDCYYCICGLP-------DYREDHAVCSILMG 391
Query: 1143 KEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
M+ + + +RVG + G + GV+G + YD+W V +A++M+ G+
Sbjct: 392 LAMVEAIS-YVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGI 450
Query: 1203 ECRIQVSEES 1212
R+ +S+ +
Sbjct: 451 PGRVHISQST 460
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 225 bits (574), Expect = 2e-58
Identities = 184/564 (32%), Positives = 276/564 (48%), Gaps = 77/564 (13%)
Query: 718 KNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPV 777
K E+ + + I + K + I + SL F ++ LE+ YR +
Sbjct: 547 KRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRAT----------- 595
Query: 778 KTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAV 837
A P F V + +F C + +P F AA LL L
Sbjct: 596 ---ALPAFKYY--VTCACLIFF-----CIFIVQILVLPKTSVLGISFGAAFLLLAFIL-- 643
Query: 838 SIRMVFFLEDVMACTKR---LLEWIAG---------WLPRHCIGAILVSLPAL-AVY--- 881
V F ++ C+K+ LL W+ W PR + I ++ + AV+
Sbjct: 644 ---FVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPW-PRISLTIITTAIILMMAVFNMF 699
Query: 882 ----SHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAG------- 930
S T N F+ S +A++ N L ++ S + ++
Sbjct: 700 FLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNY 759
Query: 931 --PLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFL 988
+L++ V+L +++L V S+ + +DL+ +G + +FF+
Sbjct: 760 ELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKT----MGSVSLSIFFI 815
Query: 989 LLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQ----- 1043
LL+ L R+ E RL + + R +I++M + LL N++P HVAE
Sbjct: 816 TLLV---LGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARS 872
Query: 1044 LKVSQTYSKNHDSGGVIFASIVNFSEFYEEN--YEGGKECYRVLNELIGDFDELLSKPDY 1101
LK + Y +++D V+FASI +F EFY E+ + G EC R+LNE+I DFD+LLSKP +
Sbjct: 873 LKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKF 932
Query: 1102 SSIEKIKTIGATYMAASGLNTAQAQDGSHPQE----HLQILFEFAKEMMRVVDDFNNNML 1157
S +EKIKTIG+TYMAA+GL+ +Q+ S E H+ + EFA ++ +D N +
Sbjct: 933 SGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHS- 991
Query: 1158 WFN-FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVL 1216
FN FKLRVG NHGP+ AGVIG K YDIWG+TVN+ASRMD+TGV +IQV+EE+ VL
Sbjct: 992 -FNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVL 1050
Query: 1217 SKMGYDFDYRGTVNVKGKGQMKTY 1240
+GY RG +NVKGKG +KTY
Sbjct: 1051 QTLGYTCTCRGIINVKGKGDLKTY 1074
Score = 190 bits (482), Expect = 9e-48
Identities = 138/453 (30%), Positives = 232/453 (51%), Gaps = 59/453 (13%)
Query: 108 CFPQTQRRFRYALFYIGFACL-LWSIYFAV------HMRSRLIVMVAPAL---CFLLVCV 157
C Q + L + +CL L +++FA+ H+ + V A A+ F+LVC+
Sbjct: 39 CMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCI 98
Query: 158 GFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTC 217
F KL L L LV + L A + G T P D
Sbjct: 99 ES---VFKKL---------LRLFSLVIWICLVAMGYLFMCFGG---------TVSPWD-- 135
Query: 218 LSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGAL 277
QV F + ++F++YT++ + ++ V S + C + G
Sbjct: 136 --QVSFF---LFIIFVVYTMLPFNMRDAIIASVLTSS-----SHTIVLSVCLSATPGGKE 185
Query: 278 H--WELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIH 335
H W++L+ ++ C + G + + ++ + T+ I LE EK +ER++
Sbjct: 186 HLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLL 245
Query: 336 SVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSI 395
S++P IA ++ + + + PK + +++ F +++ VSI
Sbjct: 246 SLLPAHIAMEMKAEIIQRLQG---------PKAGQMENTNN-----FHNLYVKRHTNVSI 291
Query: 396 LFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPR 455
L+ADIVGFT+++++ S LV +LN+LFG+FD++ +E +C +I LGDCYYCV+G P
Sbjct: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
Query: 456 ADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVN 515
+HA C++MGL M +AI++ +NMRVGVH+G VLCG++G++++++DVWS+DV
Sbjct: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
Query: 516 LANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
LAN ME GV G+VHIS T ++L+ Y++E+G
Sbjct: 412 LANHMEAGGVPGRVHISSVTLEHLNGAYKVEEG 444
Score = 79.0 bits (193), Expect = 3e-14
Identities = 47/170 (27%), Positives = 81/170 (47%), Gaps = 18/170 (10%)
Query: 388 QQIEEVSILFADIVGF----TKMSANKSAHALVGLLNDLFGRFDRLCEETK---CEKIST 440
Q + V ++FA I F T+ NK + LLN++ FD L + K EKI T
Sbjct: 881 QSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKT 940
Query: 441 LGDCYYCVAGC-----------PEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVG 489
+G Y G PE + H +E ++ ++ + +RVG
Sbjct: 941 IGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVG 1000
Query: 490 VHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYL 539
++ G V+ G++G ++ ++D+W N VN+A+ M+ GV K+ ++E T+ L
Sbjct: 1001 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVL 1050
Score = 78.2 bits (191), Expect = 5e-14
Identities = 69/294 (23%), Positives = 123/294 (41%), Gaps = 35/294 (11%)
Query: 983 VLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE 1042
V++F L + E++ + Y R K++ + Q + LL +++P H+A
Sbjct: 195 VIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAM 254
Query: 1043 QLKVS--------------------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082
++K Y K H + +++A IV F+ + G E
Sbjct: 255 EMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPG--ELV 312
Query: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142
+LNEL G FD++ + + +IK +G Y SGL + +H + +++ +
Sbjct: 313 HMLNELFGKFDQIAKE---NECMRIKILGDCYYCVSGLPISLP---NHAKNCVKMGLDMC 366
Query: 1143 KEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
+ + +V D + +RVG + G + GVIG K YD+W V +A+ M+ GV
Sbjct: 367 EAIKKVRDATG-----VDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGV 421
Query: 1203 ECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQ--MKTYLYPKCTDHRVIPQH 1254
R+ +S + L+ + G + Q +KTY R PQH
Sbjct: 422 PGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQH 475
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 221 bits (563), Expect = 4e-57
Identities = 118/323 (36%), Positives = 184/323 (56%), Gaps = 27/323 (8%)
Query: 231 LFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGC 290
LF Y+++ LPL ++ G+ S+L + P +++ +++++ +L C
Sbjct: 278 LFATYSMLPLPLTWAILAGLGTSLLQVIL------QVVIPRLAVISIN-QVVAQAVLFMC 330
Query: 291 IHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQG 350
++ G+ + +S R FL+ + + LE E +ER++ SV+PR + +++
Sbjct: 331 MNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDM 390
Query: 351 DEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANK 410
+ ++ F + + E VSILFAD+ GFT +S
Sbjct: 391 TNVEDEHLQHQ--------------------FHRIYIHRYENVSILFADVKGFTNLSTTL 430
Query: 411 SAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMI 470
SA LV +LN+LF RFDRL E C +I LGDCYYCV+G PEPR DHA+CC+EMGL MI
Sbjct: 431 SAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMI 490
Query: 471 KAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVH 530
K I K V+MR+G+H+G+VLCG+LG+R+++FDVWS DV++AN +E G+ G++H
Sbjct: 491 KTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIH 550
Query: 531 ISEATAKYLDDRYEMEDGKVIER 553
IS+AT L+ Y +E+G ER
Sbjct: 551 ISKATLDCLNGDYNVEEGHGKER 573
Score = 209 bits (532), Expect = 1e-53
Identities = 169/540 (31%), Positives = 268/540 (49%), Gaps = 70/540 (12%)
Query: 727 HFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFS 786
H +D+ D L +++ I FSL F D LE Y + ++EV K++ V F F
Sbjct: 673 HTIDLRSGDKLRREH-----IKPFSLMFKDSSLEHKY-SQMRDEVFKSNLVCAFIVLLFI 726
Query: 787 SLLDVFL--STTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFF 844
+ + L S + +T+ + + +A V A L L + I +
Sbjct: 727 TAIQSLLPSSRVMPMTIQFSILIMLHSALVL---ITTAEDYKCLPLILRKTCCWINETYL 783
Query: 845 LEDVMACTKRLLEWIAGWLPRHCIGAIL--------VSLPALAVYSHVTSEYETNIHFPV 896
+V+ L+ ++ GAIL S+P + + ++ + +P
Sbjct: 784 ARNVIIFASILINFL---------GAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPE 834
Query: 897 FTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLL---LYVSLCPDSSVLTSPLDAV 953
+ ++A+V F +L+S ++ ++ ++ A LL +Y L L
Sbjct: 835 YFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNL------- 887
Query: 954 QNFSSERNPCNSSVPRDLRRPASLIGQEVV--LVFFLLLLLVWFLNREFEVSYRLHYHGD 1011
N S E +G + V L+ + LL V++ ++ E + RL +
Sbjct: 888 -NHSGE----------------DFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWR 930
Query: 1012 VEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVS-----QTYSKNHDSGGVIFASIVN 1066
V+A +++ +R+ + +LRNI+P HVA + YS+++D+ GV+FASI
Sbjct: 931 VQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPG 990
Query: 1067 FSEFYE--ENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQ 1124
F++FY E G EC R+LNE+I DFDELL + + IEKIKTIG+TYMA SGL+ +
Sbjct: 991 FADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSP-E 1049
Query: 1125 AQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLY 1184
Q HL L +F+ + + + N + + NF+LR+G +HG + AGVIG K Y
Sbjct: 1050 KQQCEDKWGHLCALADFSLALTESIQEINKHS-FNNFELRIGISHGSVVAGVIGAKKPQY 1108
Query: 1185 DIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKG----KGQMKTY 1240
DIWG TVN+ASRMD+TGV RIQV EE+Y +L G+ FDYRG + VKG +G++KTY
Sbjct: 1109 DIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTY 1168
Score = 87.8 bits (216), Expect = 6e-17
Identities = 55/203 (27%), Positives = 100/203 (49%), Gaps = 21/203 (10%)
Query: 388 QQIEEVSILFADIVGF----TKMSANKSAHALVGLLNDLFGRFDRLCEETK---CEKIST 440
Q + V ++FA I GF ++ N + LLN++ FD L E + EKI T
Sbjct: 976 QSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKT 1035
Query: 441 LGDCYYCVAGCP------EPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGT 494
+G Y V+G E + H + L + ++I++ + +R+G+ G+
Sbjct: 1036 IGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGS 1095
Query: 495 VLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERL 554
V+ G++G ++ ++D+W VNLA+ M+ GV+G++ + E T L D+ G +
Sbjct: 1096 VVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQ-----GFAFDYR 1150
Query: 555 GQSVV---ADQLKGLKTYLISGQ 574
G+ V ++Q +KTY + G+
Sbjct: 1151 GEIYVKGISEQEGKIKTYFLLGR 1173
Score = 63.5 bits (153), Expect = 1e-09
Identities = 44/186 (23%), Positives = 86/186 (46%), Gaps = 15/186 (8%)
Query: 1032 LRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGD 1091
+ N+ H+ Q + Y +++ ++FA + F+ +E R+LNEL
Sbjct: 390 MTNVEDEHLQHQFH--RIYIHRYENVSILFADVKGFTNL--STTLSAQELVRMLNELFAR 445
Query: 1092 FDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDD 1151
FD L + +IK +G Y SGL + Q+H E M++ +
Sbjct: 446 FDRLAHE---HHCLRIKILGDCYYCVSGLPEPR-------QDHAHCCVEMGLSMIKTIR- 494
Query: 1152 FNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEE 1211
+ + + +R+G + G + GV+G K +D+W V+IA+++++ G+ RI +S+
Sbjct: 495 YVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKA 554
Query: 1212 SYRVLS 1217
+ L+
Sbjct: 555 TLDCLN 560
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 216 bits (551), Expect = 9e-56
Identities = 130/357 (36%), Positives = 201/357 (56%), Gaps = 36/357 (10%)
Query: 231 LFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGC 290
+++ YT++ + + ++ G+ S L + + G L +L + LL C
Sbjct: 246 VYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQL-------NRGDAFLWKQLGANVLLFLC 298
Query: 291 IHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQG 350
+ IG+ ++V R F + I L+ E +ER++ SV+P+ +A ++
Sbjct: 299 TNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM---- 354
Query: 351 DEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANK 410
K+ + +K + F +Q+ + VSILFADI GFT +++
Sbjct: 355 -------------------KEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQC 395
Query: 411 SAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMI 470
+A LV LN+LF RFD+L E C +I LGDCYYCV+G PE RADHA+CC+EMG+ MI
Sbjct: 396 TAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMI 455
Query: 471 KAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVH 530
+AI + VNMRVG+H+G V CG+LG+R+++FDVWSNDV LAN ME G AG++H
Sbjct: 456 EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIH 515
Query: 531 ISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISG--QRAKESRCSCAE 585
I+ AT +YL+ YE+E G+ ER + + +Q ++T+LI G Q+ KE + A+
Sbjct: 516 ITRATLQYLNGDYEVEPGRGGER--NAYLKEQ--HIETFLILGASQKRKEEKAMLAK 568
Score = 196 bits (499), Expect = 1e-49
Identities = 167/554 (30%), Positives = 265/554 (47%), Gaps = 67/554 (12%)
Query: 729 VDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEE--VIKNSPVKTFASPTFS 786
+D D L KD+ + +F L F ++LE+ Y + F F
Sbjct: 632 IDARSIDQLRKDH-----VRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFI 686
Query: 787 SLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALL----LEVLSLAV----- 837
LL +F +T+ L + + FL + AV+S L L+ LS ++
Sbjct: 687 QLL-IFPHSTLMLGIYASIFLLLLITVL-----ICAVYSCGSLFPKALQRLSRSIVRSRA 740
Query: 838 --------SIRMVFF--LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTS- 886
S+ +VF + ++ C + R C +L PA H+
Sbjct: 741 HSTAVGIFSVLLVFTSAIANMFTCNHTPI--------RSCAARMLNLTPADITACHLQQL 792
Query: 887 EYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSS----------LATVVGAGPLLLLY 936
Y + P+ G+ + Y L S + SS LA + G + L+
Sbjct: 793 NYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVL 852
Query: 937 VSLCPDSSVLTSP--LDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVW 994
+ L P +++ + L V +S + R A V+L+ F L L +
Sbjct: 853 LLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALAL--Y 910
Query: 995 FLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIP-----YHVAEQLKVSQT 1049
++ E + RL + ++A + +++ ++ LL NI+P + +A + + +
Sbjct: 911 LHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDEL 970
Query: 1050 YSKNHDSGGVIFASIVNFSEFY---EENYEGGKECYRVLNELIGDFDELLSKPDYSSIEK 1106
Y ++ + V+FASI NFSEFY E N EG EC R+LNE+I DFDE++S+ + +EK
Sbjct: 971 YYQSCECVAVMFASIANFSEFYVELEANNEG-VECLRLLNEIIADFDEIISEERFRQLEK 1029
Query: 1107 IKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVG 1166
IKTIG+TYMAASGLN + + H+ L ++A +M + N + + NF++++G
Sbjct: 1030 IKTIGSTYMAASGLNASTYDQVG--RSHITALADYAMRLMEQMKHINEHS-FNNFQMKIG 1086
Query: 1167 FNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYR 1226
N GP+ AGVIG K YDIWG+TVN++SRMD+TGV RIQV+ + Y+VL+ GY + R
Sbjct: 1087 LNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECR 1146
Query: 1227 GTVNVKGKGQMKTY 1240
G V VKGKG+M TY
Sbjct: 1147 GVVKVKGKGEMTTY 1160
Score = 84.3 bits (207), Expect = 7e-16
Identities = 81/372 (21%), Positives = 162/372 (43%), Gaps = 56/372 (15%)
Query: 218 LSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEAC--FPSPGAG 275
+S +G +M I VL L+Y V+ L L + Y +L G +E P AG
Sbjct: 833 ISSIGKLAM-IFVLGLIYLVLLL-LGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAG 890
Query: 276 ALHWELLSRGLLHGCIHAIGVHLFVMS-QVRSRSTFLKVGQSIMHGKDLEVEKALKERMI 334
+ + ++ +L + A+ ++L + +R FL Q+ +++E +A R++
Sbjct: 891 RVALKYMTPVIL--LVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLL 948
Query: 335 HSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVS 394
H+++P+ +A + + E Q E V+
Sbjct: 949 HNILPKDVAAHFLARERRNDE-----------------------------LYYQSCECVA 979
Query: 395 ILFADIVGFTK----MSANKSAHALVGLLNDLFGRFDRLCEETK---CEKISTLGDCYYC 447
++FA I F++ + AN + LLN++ FD + E + EKI T+G Y
Sbjct: 980 VMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMA 1039
Query: 448 VAGCPEPRAD-----HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGM 502
+G D H + + +++ ++ + M++G++ G V+ G++G
Sbjct: 1040 ASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGA 1099
Query: 503 RRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQ 562
R+ ++D+W N VN+++ M+ GV ++ ++ D Y++ K + + VV +
Sbjct: 1100 RKPQYDIWGNTVNVSSRMDSTGVPDRIQVT-------TDLYQVLAAKGYQLECRGVVKVK 1152
Query: 563 LKG-LKTYLISG 573
KG + TY ++G
Sbjct: 1153 GKGEMTTYFLNG 1164
Score = 82.0 bits (201), Expect = 3e-15
Identities = 104/433 (24%), Positives = 174/433 (40%), Gaps = 80/433 (18%)
Query: 799 LTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEW 858
L L T L + AA P PA +A+ + A L V L V F +D M W
Sbjct: 159 LVLLTAVLLAFHAAPARPQPAYVALLACAAALFV-GLMVVCNRHSFRQDSM--------W 209
Query: 859 IAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSW 918
+ ++ + A+ V ALA S + PVF Y + L
Sbjct: 210 VVSYVVLGILAAVQVG-GALAADPRSPS---AGLWCPVF---------FVYIAYTLLPIR 256
Query: 919 MRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLI 978
MR+++ + +G L L +L L+ F ++ N
Sbjct: 257 MRAAVLSGLGLSTLHL----------ILAWQLNRGDAFLWKQLGAN-------------- 292
Query: 979 GQEVVLVFFLLLLLVWFLNREFEVSYRLHYH---GDVEADLHRTKIQSMRDQADWLLRNI 1035
VL+F ++ + EVS R + G ++A LH +Q Q + LL ++
Sbjct: 293 ----VLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLH---LQHENRQQERLLLSV 345
Query: 1036 IPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRV 1084
+P HVA ++K + Y + HD+ ++FA I F+ + +E
Sbjct: 346 LPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT--AQELVMT 403
Query: 1085 LNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKE 1144
LNEL FD+L ++ + +IK +G Y SGL A+A +H E +
Sbjct: 404 LNELFARFDKLAAE---NHCLRIKILGDCYYCVSGLPEARA-------DHAHCCVEMGVD 453
Query: 1145 MMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1204
M+ + + N +RVG + G + GV+G K +D+W + V +A+ M+ G
Sbjct: 454 MIEAIS-LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAG 512
Query: 1205 RIQVSEESYRVLS 1217
RI ++ + + L+
Sbjct: 513 RIHITRATLQYLN 525
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 216 bits (551), Expect = 9e-56
Identities = 130/357 (36%), Positives = 201/357 (56%), Gaps = 36/357 (10%)
Query: 231 LFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGC 290
+++ YT++ + + ++ G+ S L + + G L +L + LL C
Sbjct: 246 VYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQL-------NRGDAFLWKQLGANVLLFLC 298
Query: 291 IHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQG 350
+ IG+ ++V R F + I L+ E +ER++ SV+P+ +A ++
Sbjct: 299 TNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM---- 354
Query: 351 DEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANK 410
K+ + +K + F +Q+ + VSILFADI GFT +++
Sbjct: 355 -------------------KEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQC 395
Query: 411 SAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMI 470
+A LV LN+LF RFD+L E C +I LGDCYYCV+G PE RADHA+CC+EMG+ MI
Sbjct: 396 TAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMI 455
Query: 471 KAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVH 530
+AI + VNMRVG+H+G V CG+LG+R+++FDVWSNDV LAN ME G AG++H
Sbjct: 456 EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIH 515
Query: 531 ISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISG--QRAKESRCSCAE 585
I+ AT +YL+ YE+E G+ ER + + +Q ++T+LI G Q+ KE + A+
Sbjct: 516 ITRATLQYLNGDYEVEPGRGGER--NAYLKEQ--HIETFLILGASQKRKEEKAMLAK 568
Score = 197 bits (500), Expect = 7e-50
Identities = 165/524 (31%), Positives = 254/524 (48%), Gaps = 60/524 (11%)
Query: 729 VDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEE--VIKNSPVKTFASPTFS 786
+D D L KD+ + +F L F ++LE+ Y + F F
Sbjct: 632 IDARSIDQLRKDH-----VRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFI 686
Query: 787 SLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLE--VLSLAVSIRMVFF 844
LL +F +T+ L + + FL + AV+S L + L+ SI
Sbjct: 687 QLL-IFPHSTLMLGIYASIFLLLLITVL-----ICAVYSCGSLFPKALQRLSRSIVRSRA 740
Query: 845 LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALI 904
+ LL + + + IG +L+SL A +V+ H++S G A+I
Sbjct: 741 HSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISS-----------IGKLAMI 789
Query: 905 AVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCN 964
V+ L + AT+ LLL L + + F P
Sbjct: 790 FVL---GLIYLVLLLLGPPATIFDNYDLLLGVHGLASSN----------ETFDGLDCPAA 836
Query: 965 SSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSM 1024
V P ++LVF L L L ++ E + RL + ++A + +++ +
Sbjct: 837 GRVALKYMTPV------ILLVFALALYLH---AQQVESTARLDFLWKLQATGEKEEMEEL 887
Query: 1025 RDQADWLLRNIIP-----YHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFY---EENYE 1076
+ LL NI+P + +A + + + Y ++ + V+FASI NFSEFY E N E
Sbjct: 888 QAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNE 947
Query: 1077 GGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQ 1136
G EC R+LNE+I DFDE++S+ + +EKIKTIG+TYMAASGLN + + H+
Sbjct: 948 G-VECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVG--RSHIT 1004
Query: 1137 ILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASR 1196
L ++A +M + N + + NF++++G N GP+ AGVIG K YDIWG+TVN++SR
Sbjct: 1005 ALADYAMRLMEQMKHINEHS-FNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSR 1063
Query: 1197 MDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
MD+TGV RIQV+ + Y+VL+ GY + RG V VKGKG+M TY
Sbjct: 1064 MDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTY 1107
Score = 89.0 bits (219), Expect = 3e-17
Identities = 103/508 (20%), Positives = 205/508 (40%), Gaps = 77/508 (15%)
Query: 95 FDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYF-------AVHMRSRLIVMVA 147
F +LE+ + P+ AL F C + + F ++ L++++
Sbjct: 652 FQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLIT 711
Query: 148 PALCFLLVCVGFFLFTFTKLYAR------HYAWTSLALTLLVFALTLAAQFQVLTPVSGR 201
+C + C F +L H + LLVF +A + +
Sbjct: 712 VLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFI------- 764
Query: 202 GDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGY 261
+ L+ A +S +G +M I VL L+Y V+ L L + Y +L G
Sbjct: 765 -GNMLLSLLASSVFLHISSIGKLAM-IFVLGLIYLVLLL-LGPPATIFDNYDLLLGVHGL 821
Query: 262 HFRDEAC--FPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMS-QVRSRSTFLKVGQSIM 318
+E P AG + + ++ +L + A+ ++L + +R FL Q+
Sbjct: 822 ASSNETFDGLDCPAAGRVALKYMTPVIL--LVFALALYLHAQQVESTARLDFLWKLQATG 879
Query: 319 HGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKA 378
+++E +A R++H+++P+ +A + + E
Sbjct: 880 EKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDE----------------------- 916
Query: 379 PIAFRPFKMQQIEEVSILFADIVGFTK----MSANKSAHALVGLLNDLFGRFDRLCEETK 434
Q E V+++FA I F++ + AN + LLN++ FD + E +
Sbjct: 917 ------LYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEER 970
Query: 435 ---CEKISTLGDCYYCVAGCPEPRAD-----HAYCCIEMGLGMIKAIEQFCQEKKEMVNM 486
EKI T+G Y +G D H + + +++ ++ + M
Sbjct: 971 FRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQM 1030
Query: 487 RVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEME 546
++G++ G V+ G++G R+ ++D+W N VN+++ M+ GV ++ ++ D Y++
Sbjct: 1031 KIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVT-------TDLYQVL 1083
Query: 547 DGKVIERLGQSVVADQLKG-LKTYLISG 573
K + + VV + KG + TY ++G
Sbjct: 1084 AAKGYQLECRGVVKVKGKGEMTTYFLNG 1111
Score = 82.0 bits (201), Expect = 3e-15
Identities = 104/433 (24%), Positives = 174/433 (40%), Gaps = 80/433 (18%)
Query: 799 LTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEW 858
L L T L + AA P PA +A+ + A L V L V F +D M W
Sbjct: 159 LVLLTAVLLAFHAAPARPQPAYVALLACAAALFV-GLMVVCNRHSFRQDSM--------W 209
Query: 859 IAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSW 918
+ ++ + A+ V ALA S + PVF Y + L
Sbjct: 210 VVSYVVLGILAAVQVG-GALAADPRSPS---AGLWCPVF---------FVYIAYTLLPIR 256
Query: 919 MRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLI 978
MR+++ + +G L L +L L+ F ++ N
Sbjct: 257 MRAAVLSGLGLSTLHL----------ILAWQLNRGDAFLWKQLGAN-------------- 292
Query: 979 GQEVVLVFFLLLLLVWFLNREFEVSYRLHYH---GDVEADLHRTKIQSMRDQADWLLRNI 1035
VL+F ++ + EVS R + G ++A LH +Q Q + LL ++
Sbjct: 293 ----VLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLH---LQHENRQQERLLLSV 345
Query: 1036 IPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRV 1084
+P HVA ++K + Y + HD+ ++FA I F+ + +E
Sbjct: 346 LPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT--AQELVMT 403
Query: 1085 LNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKE 1144
LNEL FD+L ++ + +IK +G Y SGL A+A +H E +
Sbjct: 404 LNELFARFDKLAAE---NHCLRIKILGDCYYCVSGLPEARA-------DHAHCCVEMGVD 453
Query: 1145 MMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1204
M+ + + N +RVG + G + GV+G K +D+W + V +A+ M+ G
Sbjct: 454 MIEAIS-LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAG 512
Query: 1205 RIQVSEESYRVLS 1217
RI ++ + + L+
Sbjct: 513 RIHITRATLQYLN 525
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 215 bits (547), Expect = 3e-55
Identities = 149/457 (32%), Positives = 218/457 (47%), Gaps = 55/457 (12%)
Query: 94 KFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFL 153
KF S LE F Q + + CL+ + A +L P L L
Sbjct: 220 KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQL-----PYLAVL 274
Query: 154 LVCVGFFLF--TFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATA 211
VG L A H LA L+ A+ LA Q L R S + T
Sbjct: 275 AAAVGVILIMAVLCNRAAFHQDHMGLACYALI-AVVLAVQVVGLLLPQPRSASEGIWWT- 332
Query: 212 RPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPS 271
+ ++ +YT++ + + ++ GV S L + F
Sbjct: 333 ----------------VFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQF-- 374
Query: 272 PGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKE 331
L +L+S L+ C + +GV ++V R F + + I + E +E
Sbjct: 375 -----LLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQE 429
Query: 332 RMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIE 391
R++ SV+PR +A ++ + + E+ + F +Q+ +
Sbjct: 430 RLLLSVLPRHVAMEMKADINAKQEDMM-----------------------FHKIYIQKHD 466
Query: 392 EVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGC 451
VSILFADI GFT +++ +A LV LN+LF RFD+L E C +I LGDCYYCV+G
Sbjct: 467 NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL 526
Query: 452 PEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWS 511
PE RADHA+CC+EMG+ MI+AI + VNMRVG+H+G V CG+LG+R+++FDVWS
Sbjct: 527 PEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS 586
Query: 512 NDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
NDV LAN ME G AG++HI++AT YL+ YE+E G
Sbjct: 587 NDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPG 623
Score = 197 bits (502), Expect = 4e-50
Identities = 160/528 (30%), Positives = 266/528 (50%), Gaps = 46/528 (8%)
Query: 747 INQFSLNFLDQELERSYRTSYQEE----VIKNSPVKTFAS-------PTFSSLLDVFLST 795
+ +F L F + +LE+ Y + V S V F P +L +L+
Sbjct: 737 VRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTC 796
Query: 796 TVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAV----SIRMVFFLEDVMAC 851
++ LTL + Y + P P L S ++ ++ + +I +VF V
Sbjct: 797 SLLLTLVVFVSVIYSCVKLFPSP--LQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMF 854
Query: 852 TKRLLEWIAGWLPRHCIGAILVS---LPALAVYSHVTSEYE------TNIHFPVFTGSAA 902
T + + H I A V+ + AV + E N +FP + +
Sbjct: 855 TCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSV 914
Query: 903 LIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP--DSSVLTSPLDAVQNFSSER 960
L++++ F Q+S + L + +L++ V D++ L +A+ F++
Sbjct: 915 LLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGT 974
Query: 961 NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTK 1020
+ C P + A + +++ F+L L + ++ E + RL + ++A + +
Sbjct: 975 SQC----PEHATKVALKVVTPIIISVFVLAL--YLHAQQVESTARLDFLWKLQATEEKEE 1028
Query: 1021 IQSMRDQADWLLRNIIP-----YHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFY---E 1072
++ ++ LL NI+P + +A + + + Y ++ + V+FASI NFSEFY E
Sbjct: 1029 MEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE 1088
Query: 1073 ENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQ 1132
N EG EC R+LNE+I DFDE++S+ + +EKIKTIG+TYMAASGLN + +
Sbjct: 1089 ANNEG-VECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVG--K 1145
Query: 1133 EHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVN 1192
H++ L +FA ++M + N + + NF++++G N GP+ AGVIG K YDIWG+TVN
Sbjct: 1146 THIKALADFAMKLMDQMKYINEHS-FNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVN 1204
Query: 1193 IASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
+ASRMD+TGV RIQV+ + Y+VL+ Y + RG V VKGKG+M TY
Sbjct: 1205 VASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTY 1252
Score = 85.5 bits (210), Expect = 3e-16
Identities = 72/290 (24%), Positives = 127/290 (43%), Gaps = 35/290 (12%)
Query: 1001 EVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVS-----------QT 1049
EVS R + E R Q Q + LL +++P HVA ++K +
Sbjct: 401 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKI 460
Query: 1050 YSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKT 1109
Y + HD+ ++FA I F+ + +E LNEL FD+L ++ + +IK
Sbjct: 461 YIQKHDNVSILFADIEGFTSLASQCT--AQELVMTLNELFARFDKLAAE---NHCLRIKI 515
Query: 1110 IGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNH 1169
+G Y SGL A+A +H E +M+ + + N +RVG +
Sbjct: 516 LGDCYYCVSGLPEARA-------DHAHCCVEMGMDMIEAIS-LVREVTGVNVNMRVGIHS 567
Query: 1170 GPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTV 1229
G + GV+G K +D+W + V +A+ M+ G RI +++ + L+ + D++
Sbjct: 568 GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKAT---LNYLNGDYEVEPGC 624
Query: 1230 NVKGKGQMK-----TYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSP 1274
+ +K T+L +CT R + + ++ + Q SIG +P
Sbjct: 625 GGERNAYLKEHSIETFLILRCTQKR---KEEKAMIAKMNRQRTNSIGHNP 671
Score = 80.9 bits (198), Expect = 8e-15
Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 61/287 (21%)
Query: 306 SRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSS 365
+R FL Q+ +++E +A R++H+++P+ +A + + E
Sbjct: 1012 ARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDE---------- 1061
Query: 366 PKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTK----MSANKSAHALVGLLND 421
Q E V+++FA I F++ + AN + LLN+
Sbjct: 1062 -------------------LYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNE 1102
Query: 422 LFGRFDRLCEETK---CEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQ 478
+ FD + E + EKI T+G Y +G + D ++G IKA+ F
Sbjct: 1103 IIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYD------KVGKTHIKALADFAM 1156
Query: 479 EKKEMVN-----------MRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAG 527
+ + + M++G++ G V+ G++G R+ ++D+W N VN+A+ M+ GV
Sbjct: 1157 KLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPD 1216
Query: 528 KVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKG-LKTYLISG 573
++ ++ D Y++ + + VV + KG + TY ++G
Sbjct: 1217 RIQVT-------TDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1256
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 211 bits (536), Expect = 5e-54
Identities = 131/375 (34%), Positives = 199/375 (53%), Gaps = 42/375 (11%)
Query: 182 LVFALTLA---AQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVM 238
L+F+LT A F + P G ++ ATA + G + + + V F+ Y ++
Sbjct: 127 LLFSLTFALLCCPFALGGPARGSAGAAGGPATA--------EQGVWQLLL-VTFVSYALL 177
Query: 239 HLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHL 298
+ L++ G+ + H A L L + LL ++ GV +
Sbjct: 178 PVRSLLAIGFGLVVAAS------HLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFV 231
Query: 299 FVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSV 358
++++ R FL+ I LE E +ER++ S++PR +A ++
Sbjct: 232 RILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEM------------ 279
Query: 359 KRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGL 418
K+ ++ F +Q+ + VSILFADIVGFT +++ +A LV L
Sbjct: 280 ------------KEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKL 327
Query: 419 LNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQ 478
LN+LFG+FD L E C +I LGDCYYCV+G +P+ DHA+CC+EMGL MI I +
Sbjct: 328 LNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAE 387
Query: 479 EKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKY 538
+ +NMRVG+HTG VLCG+LG+R++++DVWSNDV LAN+ME G+ GKVHI++ T
Sbjct: 388 ATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLAC 447
Query: 539 LDDRYEMEDGKVIER 553
L+ YE+E G ER
Sbjct: 448 LNGDYEVEPGYGHER 462
Score = 204 bits (520), Expect = 4e-52
Identities = 166/516 (32%), Positives = 238/516 (46%), Gaps = 56/516 (10%)
Query: 747 INQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSL--LDVFLSTTVFLTLSTT 804
+N F+L + E E+ Y Q+E ++ V T L L +F + V L L
Sbjct: 585 LNFFTLKYKHVEREQKYH-QLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVF 643
Query: 805 CFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLP 864
C A + + F L +++ ++ +V C L W P
Sbjct: 644 CICFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKP 703
Query: 865 RHCI-----GAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWM 919
+ G +LP L S H+ C L +
Sbjct: 704 NSSLVVLSSGGQRTALPTLPCES------------------------THHALLCCLVGTL 739
Query: 920 RSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIG 979
++ V + P ++L S LT+ V S +V P I
Sbjct: 740 PLAIFFRVSSLPKMILL-------SGLTTSYILVLELSGYTRTGGGAVSGRSYEPIVAI- 791
Query: 980 QEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYH 1039
L+F L L R+ ++ RL Y +A+ R ++ ++ +L N++P H
Sbjct: 792 ----LLFSCALALH---ARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAH 844
Query: 1040 VAEQLKVSQT-----YSKNHDSGGVIFASIVNFSEFYEE--NYEGGKECYRVLNELIGDF 1092
VA+ +S Y +++ GV+FASI NF++FY E G EC R+LNE+I DF
Sbjct: 845 VAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADF 904
Query: 1093 DELLSKPDYSSIEKIKTIGATYMAASGLN-TAQAQDGSHPQEHLQILFEFAKEMMRVVDD 1151
DEL+ K Y IEKIKTIG+TYMAA GL T+ + HL L +FA EM V+D+
Sbjct: 905 DELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDE 964
Query: 1152 FNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEE 1211
N + +F LRVG N GP+ AGVIG + YDIWG+TVN+ASRMD+TGV+ RIQV+EE
Sbjct: 965 INYQS-YNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEE 1023
Query: 1212 SYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTD 1247
+R+L + Y F RG V+VKGKG+M TY TD
Sbjct: 1024 VHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTD 1059
Score = 92.4 bits (228), Expect = 3e-18
Identities = 97/449 (21%), Positives = 183/449 (40%), Gaps = 75/449 (16%)
Query: 126 ACLLWSIYFAVHMRSRLIVMVAP-ALCFLLVCVGFFLFTFTKLYA-----RHYAWTSLAL 179
A L +Y + +S +++++ +CFL+ CV + T + + + + +
Sbjct: 620 AALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFI 679
Query: 180 TLLVFALTLAAQFQVLTPVSGRGDSSNLTA-------TARPTDTCLSQVGSFSMCIE--- 229
+L++++ L +S+L TA PT C S + C+
Sbjct: 680 VVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTL 739
Query: 230 VLFLLYTVMHLPLYLSLC-LGVAYSVLFETFGYHFRDEACFPSPGAGALH---WELLSRG 285
L + + V LP + L L +Y ++ E GY G GA+ +E +
Sbjct: 740 PLAIFFRVSSLPKMILLSGLTTSYILVLELSGY--------TRTGGGAVSGRSYEPIVAI 791
Query: 286 LLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADD 345
LL C A+ +H + +R R +L Q+ +D+E K R++ +++P +A
Sbjct: 792 LLFSC--ALALHARQVD-IRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQH 848
Query: 346 LMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFT- 404
+ S+P+N Q +V ++FA I F
Sbjct: 849 FLM---------------SNPRNMD--------------LYYQSYSQVGVMFASIPNFND 879
Query: 405 ---KMSANKSAHALVGLLNDLFGRFDRLCEET---KCEKISTLGDCYYCVAG-------- 450
++ N + LLN++ FD L E+ EKI T+G Y G
Sbjct: 880 FYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTK 939
Query: 451 CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVW 510
+ + H + + M +++ + +RVG++ G V+ G++G RR ++D+W
Sbjct: 940 AKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIW 999
Query: 511 SNDVNLANLMEQLGVAGKVHISEATAKYL 539
N VN+A+ M+ GV G++ ++E + L
Sbjct: 1000 GNTVNVASRMDSTGVQGRIQVTEEVHRLL 1028
Score = 80.9 bits (198), Expect = 8e-15
Identities = 58/255 (22%), Positives = 118/255 (46%), Gaps = 29/255 (11%)
Query: 1018 RTKIQSMRDQADWLLRNIIPYHVAEQLKVS----------QTYSKNHDSGGVIFASIVNF 1067
R +++ ++ + LL +++P +VA ++K + Y + HD+ ++FA IV F
Sbjct: 253 RLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGF 312
Query: 1068 SEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQD 1127
+ + +E ++LNEL G FDEL ++ + +IK +G Y SGL +
Sbjct: 313 TGLASQCT--AQELVKLLNELFGKFDELATE---NHCRRIKILGDCYYCVSGLTQPKT-- 365
Query: 1128 GSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIW 1187
+H E +M+ + + +RVG + G + GV+G K YD+W
Sbjct: 366 -----DHAHCCVEMGLDMIDTITSVAE-ATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVW 419
Query: 1188 GDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTD 1247
+ V +A+ M+ G+ ++ +++ + L+ + D++ + +KT+
Sbjct: 420 SNDVTLANVMEAAGLPGKVHITKTT---LACLNGDYEVEPGYGHERNSFLKTH---NIET 473
Query: 1248 HRVIPQHQLSISPDI 1262
++P H+ I P +
Sbjct: 474 FFIVPSHRRKIFPGL 488
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 202 bits (513), Expect = 2e-51
Identities = 120/275 (43%), Positives = 172/275 (62%), Gaps = 18/275 (6%)
Query: 984 LVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQ 1043
LV F + LL L+R+ + RL + + ++M + LL N++P HVA
Sbjct: 803 LVLFYITLLT--LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAH 860
Query: 1044 L---KVSQT-YSKNHDSGGVIFASIVNFSEFYEE---NYEGGKECYRVLNELIGDFDELL 1096
K+++ Y +++D V+FAS+ +F FY E N EG EC R+LNE+I DFDELL
Sbjct: 861 FIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEG-LECLRLLNEIIADFDELL 919
Query: 1097 SKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQE---HLQILFEFAKEMMRVVDDFN 1153
KP +S +EKIKTIG+TYMAA+GL+ A + + H+ ++ EF+ +M +D N
Sbjct: 920 LKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGIN 979
Query: 1154 NNMLWFN-FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEES 1212
+ FN F+LRVG NHGP+ AGVIG K YDIWG+TVN+ASRM++TG +IQV+EE+
Sbjct: 980 RHS--FNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEET 1037
Query: 1213 YRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTD 1247
+L +GY + RG +NVKGKG+++TY CTD
Sbjct: 1038 CTILQGLGYSCECRGLINVKGKGELRTYFV--CTD 1070
Score = 196 bits (497), Expect = 2e-49
Identities = 120/351 (34%), Positives = 193/351 (54%), Gaps = 25/351 (7%)
Query: 230 VLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHG 289
++F++YT++ + ++ +G + PS G +LL+ ++
Sbjct: 132 IVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGL---QLLANAVIFL 188
Query: 290 CIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQ 349
C + G Q SR F + I + L +EK +E ++ SV+P I+ +
Sbjct: 189 CGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLA 248
Query: 350 GDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSAN 409
E + R P N F +++ + VSIL+ADIVGFT+++++
Sbjct: 249 IIERLKEHGDRRCM--PDNN------------FHSLYVKRHQNVSILYADIVGFTQLASD 294
Query: 410 KSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGM 469
S LV +LN+LFG+FD++ + +C +I LGDCYYCV+G P HA C++MGL M
Sbjct: 295 CSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDM 354
Query: 470 IKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKV 529
+AI+Q + +NMRVG+H+G VLCG++G+R++++DVWS+DV+LAN ME GV G+V
Sbjct: 355 CQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRV 414
Query: 530 HISEATAKYLDDRYEMEDGKVIERLGQSVVADQLK--GLKTYLISGQRAKE 578
HI+EAT K+LD YE+EDG +R LK ++TYL+ R+++
Sbjct: 415 HITEATLKHLDKAYEVEDGHGQQR------DPYLKEMNIRTYLVIDPRSQQ 459
Score = 82.8 bits (203), Expect = 2e-15
Identities = 57/208 (27%), Positives = 95/208 (45%), Gaps = 25/208 (12%)
Query: 388 QQIEEVSILFADI----VGFTKMSANKSAHALVGLLNDLFGRFDRLCEETK---CEKIST 440
Q + V ++FA + V +T+ NK + LLN++ FD L + K EKI T
Sbjct: 873 QSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKT 932
Query: 441 LGDCYYCVAGCP----------EPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGV 490
+G Y AG E + H +E + ++ ++ + +RVG+
Sbjct: 933 IGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGI 992
Query: 491 HTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD-RYEMEDGK 549
+ G V+ G++G R+ ++D+W N VN+A+ ME G GK+ ++E T L Y E
Sbjct: 993 NHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRG 1052
Query: 550 VIERLGQSVVADQLKGLKTYLISGQRAK 577
+I G+ L+TY + AK
Sbjct: 1053 LINVKGKG-------ELRTYFVCTDTAK 1073
Score = 82.4 bits (202), Expect = 3e-15
Identities = 65/260 (25%), Positives = 115/260 (44%), Gaps = 42/260 (16%)
Query: 988 LLLLLVWFLNREFEVSYRLHYHGDVEADLH---------RTKIQSMRDQADWLLRNIIPY 1038
LL V FL ++ H D DL R K++ + Q + LL +++P
Sbjct: 180 LLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPA 239
Query: 1039 HVAEQLKVS--------------------QTYSKNHDSGGVIFASIVNFSEFYEENYEGG 1078
H++ +K++ Y K H + +++A IV F++ +
Sbjct: 240 HISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDC--SP 297
Query: 1079 KECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQIL 1138
KE VLNEL G FD++ + +IK +G Y SGL + +H + +++
Sbjct: 298 KELVVVLNELFGKFDQIAKA---NECMRIKILGDCYYCVSGLPVSLP---THARNCVKMG 351
Query: 1139 FEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMD 1198
+ + + +V + +RVG + G + GVIG K YD+W V++A+RM+
Sbjct: 352 LDMCQAIKQV-----REATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRME 406
Query: 1199 TTGVECRIQVSEESYRVLSK 1218
GV R+ ++E + + L K
Sbjct: 407 AAGVPGRVHITEATLKHLDK 426
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 111 bits (278), Expect = 4e-24
Identities = 75/217 (34%), Positives = 117/217 (53%), Gaps = 14/217 (6%)
Query: 1027 QADWLLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVL 1085
+A+ LL I+P+ VAEQLK +T ++ DS + F+ IV F+ E+ + +L
Sbjct: 829 KAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTP--MQVVTLL 886
Query: 1086 NELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEM 1145
N+L FD ++ D + K++TIG YM SGL G + Q H + A +
Sbjct: 887 NDLYTCFDAIIDNFD---VYKVETIGDAYMVVSGL------PGRNGQRHAPEIARMALAL 937
Query: 1146 MRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1204
+ V F + +LR+G + GP+ AGV+G Y ++GDTVN ASRM++ G
Sbjct: 938 LDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAL 997
Query: 1205 RIQVSEESYRVLSKMG-YDFDYRGTVNVKGKGQMKTY 1240
+I VS + L ++G + + RG V +KGKG+M+TY
Sbjct: 998 KIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTY 1034
Score = 103 bits (258), Expect = 9e-22
Identities = 62/193 (32%), Positives = 104/193 (53%), Gaps = 12/193 (6%)
Query: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
+ + V+I F+DIVGFT +SA + +V LLNDL+ FD + + K+ T+GD Y
Sbjct: 855 EAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMV 914
Query: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQF--CQEKKEMVNMRVGVHTGTVLCGILGMRR 504
V+G P HA M L ++ A+ F + + +R+GVHTG V G++G++
Sbjct: 915 VSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKM 974
Query: 505 FKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR--YEMEDGKVIERLGQSVVADQ 562
++ ++ + VN A+ ME G A K+H+S T LD+ +++E +E G+
Sbjct: 975 PRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKG----- 1029
Query: 563 LKGLKTYLISGQR 575
++TY + G+R
Sbjct: 1030 --KMRTYWLLGER 1040
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 107 bits (266), Expect = 1e-22
Identities = 64/198 (32%), Positives = 107/198 (54%), Gaps = 12/198 (6%)
Query: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
+ + V+I F+DIVGFT +SA + +V LLNDL+ FD + + K+ T+GD Y
Sbjct: 870 EAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMV 929
Query: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQF--CQEKKEMVNMRVGVHTGTVLCGILGMRR 504
V+G P HA M L ++ A+ F +E + +R+G+HTG V G++G++
Sbjct: 930 VSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKM 989
Query: 505 FKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD--RYEMEDGKVIERLGQSVVADQ 562
++ ++ + VN A+ ME G A K+H+S T L++ +E+E +E G+ V
Sbjct: 990 PRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKV--- 1046
Query: 563 LKGLKTYLISGQRAKESR 580
+TY + G+R +R
Sbjct: 1047 ----RTYWLLGERGSSTR 1060
Score = 106 bits (264), Expect = 2e-22
Identities = 73/217 (33%), Positives = 117/217 (53%), Gaps = 14/217 (6%)
Query: 1027 QADWLLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVL 1085
+A+ LL I+P+ VAEQLK +T ++ DS + F+ IV F+ E+ + +L
Sbjct: 844 KAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTP--MQVVTLL 901
Query: 1086 NELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEM 1145
N+L FD ++ D + K++TIG YM SGL + H + A +
Sbjct: 902 NDLYTCFDAVIDNFD---VYKVETIGDAYMVVSGLPVRNGR------LHACEVARMALAL 952
Query: 1146 MRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1204
+ V F + +LR+G + GP+ AGV+G Y ++GDTVN ASRM++ G
Sbjct: 953 LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 1012
Query: 1205 RIQVSEESYRVLSKM-GYDFDYRGTVNVKGKGQMKTY 1240
+I +S E+ VL + G++ + RG V +KGKG+++TY
Sbjct: 1013 KIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTY 1049
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 105 bits (263), Expect = 2e-22
Identities = 72/224 (32%), Positives = 113/224 (50%), Gaps = 41/224 (18%)
Query: 323 LEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAF 382
LE EK + +++SV+P +A++L RH
Sbjct: 383 LEDEKKKTDTLLYSVLPPSVANEL-------------RHK-------------------- 409
Query: 383 RPFKMQQIEEVSILFADIVGF----TKMSANKSAHALVGLLNDLFGRFDRLCEETK---C 435
RP ++ + V+ILF+ IVGF +K ++ + A +V LLNDL+ RFD L + K
Sbjct: 410 RPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFV 469
Query: 436 EKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTV 495
K+ T+GD Y V+G PEP HA + L M++ Q Q E V + +G+HTG V
Sbjct: 470 YKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEV 528
Query: 496 LCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYL 539
+ G++G R ++ ++ N VNL + E G GK+++SE T + L
Sbjct: 529 VTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572
Score = 100 bits (248), Expect = 1e-20
Identities = 70/250 (28%), Positives = 126/250 (50%), Gaps = 20/250 (8%)
Query: 996 LNREFEVSYRLHYHGDVEADLHRTKIQSMRDQ---ADWLLRNIIPYHVAEQLKVSQTY-S 1051
L +F Y+L ++ D + ++++ D+ D LL +++P VA +L+ + +
Sbjct: 355 LGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPA 414
Query: 1052 KNHDSGGVIFASIVNFSEFYEENY--EGGKECYRVLNELIGDFDELLSKPDYSSIEKIKT 1109
K +D+ ++F+ IV F+ F ++ EG + +LN+L FD L + K++T
Sbjct: 415 KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVET 474
Query: 1110 IGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNH 1169
+G YM SGL H + + A +MM + + + ++ +G +
Sbjct: 475 VGDKYMTVSGLPEPCIH-------HARSICHLALDMMEIAGQVQVD--GESVQITIGIHT 525
Query: 1170 GPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVL-----SKMGYDFD 1224
G + GVIG Y ++G+TVN+ SR +TTG + +I VSE +YR L S + +
Sbjct: 526 GEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLE 585
Query: 1225 YRGTVNVKGK 1234
+RG V++KGK
Sbjct: 586 HRGPVSMKGK 595
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 101 bits (251), Expect = 6e-21
Identities = 54/155 (34%), Positives = 91/155 (58%), Gaps = 2/155 (1%)
Query: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
++ V++LF+DIVGFT + + S ++ +LN L+ RFD+ C E K+ T+GD YC
Sbjct: 240 KKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YC 298
Query: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFK 506
VAG +D HA M L M++ ++ E + MR+G+H+G+V G++G++ +
Sbjct: 299 VAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPR 358
Query: 507 FDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD 541
+ ++ N+V LAN E V K+++S T + L D
Sbjct: 359 YCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 393
Score = 63.5 bits (153), Expect = 1e-09
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 1031 LLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELI 1089
LL +I P VA+QL Q +K + ++F+ IV F+ + + +LN L
Sbjct: 218 LLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQC--SPLQVITMLNALY 275
Query: 1090 GDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVV 1149
FD+ + D + K++TIG Y A GL+ H + A +MM +
Sbjct: 276 TRFDQQCGELD---VYKVETIGDAYCVAGGLH-------KESDTHAVQIALMALKMMELS 325
Query: 1150 DDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVS 1209
D+ + K+R+G + G + AGV+G Y ++G+ V +A++ ++ V +I VS
Sbjct: 326 DEVMSPH-GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 384
Query: 1210 EESYRVL 1216
+YR+L
Sbjct: 385 PTTYRLL 391
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 101 bits (251), Expect = 6e-21
Identities = 54/155 (34%), Positives = 91/155 (58%), Gaps = 2/155 (1%)
Query: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
++ V++LF+DIVGFT + + S ++ +LN L+ RFD+ C E K+ T+GD YC
Sbjct: 475 KKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YC 533
Query: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFK 506
VAG +D HA M L M++ ++ E + MR+G+H+G+V G++G++ +
Sbjct: 534 VAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPR 593
Query: 507 FDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD 541
+ ++ N+V LAN E V K+++S T + L D
Sbjct: 594 YCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
Score = 63.5 bits (153), Expect = 1e-09
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 1031 LLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELI 1089
LL +I P VA+QL Q +K + ++F+ IV F+ + + +LN L
Sbjct: 453 LLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQC--SPLQVITMLNALY 510
Query: 1090 GDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVV 1149
FD+ + D + K++TIG Y A GL+ H + A +MM +
Sbjct: 511 TRFDQQCGELD---VYKVETIGDAYCVAGGLH-------KESDTHAVQIALMALKMMELS 560
Query: 1150 DDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVS 1209
D+ + K+R+G + G + AGV+G Y ++G+ V +A++ ++ V +I VS
Sbjct: 561 DEVMSPH-GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619
Query: 1210 EESYRVL 1216
+YR+L
Sbjct: 620 PTTYRLL 626
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 101 bits (251), Expect = 6e-21
Identities = 54/155 (34%), Positives = 91/155 (58%), Gaps = 2/155 (1%)
Query: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
++ V++LF+DIVGFT + + S ++ +LN L+ RFD+ C E K+ T+GD YC
Sbjct: 475 KKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YC 533
Query: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFK 506
VAG +D HA M L M++ ++ E + MR+G+H+G+V G++G++ +
Sbjct: 534 VAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPR 593
Query: 507 FDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD 541
+ ++ N+V LAN E V K+++S T + L D
Sbjct: 594 YCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
Score = 63.5 bits (153), Expect = 1e-09
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 1031 LLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELI 1089
LL +I P VA+QL Q +K + ++F+ IV F+ + + +LN L
Sbjct: 453 LLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQC--SPLQVITMLNALY 510
Query: 1090 GDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVV 1149
FD+ + D + K++TIG Y A GL+ H + A +MM +
Sbjct: 511 TRFDQQCGELD---VYKVETIGDAYCVAGGLH-------KESDTHAVQIALMALKMMELS 560
Query: 1150 DDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVS 1209
D+ + K+R+G + G + AGV+G Y ++G+ V +A++ ++ V +I VS
Sbjct: 561 DEVMSPH-GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619
Query: 1210 EESYRVL 1216
+YR+L
Sbjct: 620 PTTYRLL 626
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 101 bits (251), Expect = 6e-21
Identities = 54/155 (34%), Positives = 91/155 (58%), Gaps = 2/155 (1%)
Query: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
++ V++LF+DIVGFT + + S ++ +LN L+ RFD+ C E K+ T+GD YC
Sbjct: 475 KKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YC 533
Query: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFK 506
VAG +D HA M L M++ ++ E + MR+G+H+G+V G++G++ +
Sbjct: 534 VAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPR 593
Query: 507 FDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD 541
+ ++ N+V LAN E V K+++S T + L D
Sbjct: 594 YCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
Score = 63.5 bits (153), Expect = 1e-09
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 1031 LLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELI 1089
LL +I P VA+QL Q +K + ++F+ IV F+ + + +LN L
Sbjct: 453 LLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQC--SPLQVITMLNALY 510
Query: 1090 GDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVV 1149
FD+ + D + K++TIG Y A GL+ H + A +MM +
Sbjct: 511 TRFDQQCGELD---VYKVETIGDAYCVAGGLH-------KESDTHAVQIALMALKMMELS 560
Query: 1150 DDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVS 1209
D+ + K+R+G + G + AGV+G Y ++G+ V +A++ ++ V +I VS
Sbjct: 561 DEVMSPH-GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619
Query: 1210 EESYRVL 1216
+YR+L
Sbjct: 620 PTTYRLL 626
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 101 bits (251), Expect = 6e-21
Identities = 54/155 (34%), Positives = 91/155 (58%), Gaps = 2/155 (1%)
Query: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
++ V++LF+DIVGFT + + S ++ +LN L+ RFD+ C E K+ T+GD YC
Sbjct: 475 KKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YC 533
Query: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFK 506
VAG +D HA M L M++ ++ E + MR+G+H+G+V G++G++ +
Sbjct: 534 VAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPR 593
Query: 507 FDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD 541
+ ++ N+V LAN E V K+++S T + L D
Sbjct: 594 YCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKD 628
Score = 63.5 bits (153), Expect = 1e-09
Identities = 52/187 (27%), Positives = 90/187 (48%), Gaps = 14/187 (7%)
Query: 1031 LLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELI 1089
LL +I P VA+QL Q +K + ++F+ IV F+ + + +LN L
Sbjct: 453 LLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQC--SPLQVITMLNALY 510
Query: 1090 GDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVV 1149
FD+ + D + K++TIG Y A GL+ H + A +MM +
Sbjct: 511 TRFDQQCGELD---VYKVETIGDAYCVAGGLH-------KESDTHAVQIALMALKMMELS 560
Query: 1150 DDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVS 1209
D+ + K+R+G + G + AGV+G Y ++G+ V +A++ ++ V +I VS
Sbjct: 561 DEVMSPH-GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619
Query: 1210 EESYRVL 1216
+YR+L
Sbjct: 620 PTTYRLL 626
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 100 bits (250), Expect = 7e-21
Identities = 77/240 (32%), Positives = 126/240 (52%), Gaps = 19/240 (7%)
Query: 1008 YHGDVEADLHRTKIQSM---RDQADWLLRNIIPYHVAEQLKVSQTYS-KNHDSGGVIFAS 1063
Y ++E DL R + + + + + + LL ++P VAE LK T + D + F+
Sbjct: 831 YSSNLE-DLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSD 889
Query: 1064 IVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTA 1123
IV F+ + E +LN+L FD ++ D + K++TIG YM ASGL
Sbjct: 890 IVGFTTISAMSEP--IEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGL--- 941
Query: 1124 QAQDGSHPQEHLQILFEFAKEMMRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKL 1182
++GS H + + +++ V F +M ++R+G + GP+ AGV+G T
Sbjct: 942 PKRNGSR---HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMP 998
Query: 1183 LYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKM--GYDFDYRGTVNVKGKGQMKTY 1240
Y ++GDTVN ASRM++TG+ RI VS + +L + GY+ + RG +KGKG +T+
Sbjct: 999 RYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETF 1058
Score = 94.0 bits (232), Expect = 9e-19
Identities = 66/251 (26%), Positives = 122/251 (48%), Gaps = 43/251 (17%)
Query: 321 KDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPI 380
++LE+EK E+++ ++P +A+ S+K+ T P+
Sbjct: 844 EELEIEKQKTEKLLTQMLPPSVAE------------SLKKGCTVEPEG------------ 879
Query: 381 AFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKIST 440
+ V++ F+DIVGFT +SA +V LLNDL+ FD + K+ T
Sbjct: 880 ---------FDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVET 930
Query: 441 LGDCYYCVAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQE--KKEMVNMRVGVHTGTVLC 497
+GD Y +G P+ HA M L ++ ++ F + V +R+G+H+G V+
Sbjct: 931 IGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVA 990
Query: 498 GILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQS 557
G++G+ ++ ++ + VN A+ ME G+ ++H+S +T L + + +G +E G++
Sbjct: 991 GVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQN---LSEGYEVELRGRT 1047
Query: 558 VVADQLKGLKT 568
+LKG T
Sbjct: 1048 ----ELKGKGT 1054
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 99.0 bits (245), Expect = 3e-20
Identities = 68/244 (27%), Positives = 125/244 (51%), Gaps = 15/244 (6%)
Query: 316 SIMHGKDL--EVEKALKERMIHSVMPRIIA-----DDLMKQGDEESENSVKRHATSSPKN 368
S+ H DL + K K +I S++ + +DL+++ EE E +++ T
Sbjct: 797 SMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELE--LEKQKTDRLLT 854
Query: 369 RKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDR 428
+ S+ +A P + + E+V++ F+DIVGFT +SA +V LLNDL+ FD
Sbjct: 855 QMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDA 914
Query: 429 LCEETKCEKISTLGDCYYCVAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQE--KKEMVN 485
+ K+ T+GD Y +G P+ HA M L ++ A+ F + V
Sbjct: 915 IIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVR 974
Query: 486 MRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATA---KYLDDR 542
+R+G+H+G + G++G+ ++ ++ + VN A+ ME G+ ++H++ +T + LD
Sbjct: 975 IRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSG 1034
Query: 543 YEME 546
Y++E
Sbjct: 1035 YQVE 1038
Score = 97.8 bits (242), Expect = 6e-20
Identities = 74/240 (30%), Positives = 119/240 (49%), Gaps = 19/240 (7%)
Query: 1008 YHGDVEADLHRTKIQSM---RDQADWLLRNIIPYHVAEQLKVSQTYSKNH-DSGGVIFAS 1063
Y ++E DL R + + + + + D LL ++P VAE LK + + + F+
Sbjct: 827 YSSNLE-DLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSD 885
Query: 1064 IVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTA 1123
IV F+ + E +LN+L FD ++ D + K++TIG YM ASGL
Sbjct: 886 IVGFTTISAMSEP--IEVVDLLNDLYTLFDAIIGSHD---VYKVETIGDAYMVASGLPQR 940
Query: 1124 QAQDGSHPQEHLQILFEFAKEMMRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKL 1182
Q H + + +++ V F +M ++R+G + GP AGV+G T
Sbjct: 941 NGQ------RHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMP 994
Query: 1183 LYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKM--GYDFDYRGTVNVKGKGQMKTY 1240
Y ++GDTVN ASRM++TG+ RI V+ + +L + GY + RG +KGKG T+
Sbjct: 995 RYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTF 1054
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 98.2 bits (243), Expect = 5e-20
Identities = 52/149 (34%), Positives = 88/149 (59%), Gaps = 2/149 (1%)
Query: 388 QQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYC 447
++ V++LF+DIVGFT + + S ++ +LN L+ RFD+ C E K+ T+GD YC
Sbjct: 475 KKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YC 533
Query: 448 VAGCPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFK 506
VAG +D HA M L M++ ++ E + MR+G+H+G+V G++G++ +
Sbjct: 534 VAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPR 593
Query: 507 FDVWSNDVNLANLMEQLGVAGKVHISEAT 535
+ ++ N+V LAN E V K+++S T
Sbjct: 594 YCLFGNNVTLANKFESCSVPRKINVSPTT 622
Score = 61.6 bits (148), Expect = 5e-09
Identities = 51/185 (27%), Positives = 88/185 (47%), Gaps = 14/185 (7%)
Query: 1031 LLRNIIPYHVAEQLKVSQTY-SKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELI 1089
LL +I P VA+QL Q +K + ++F+ IV F+ + + +LN L
Sbjct: 453 LLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQC--SPLQVITMLNALY 510
Query: 1090 GDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVV 1149
FD+ + D + K++TIG Y A GL+ H + A +MM +
Sbjct: 511 TRFDQQCGELD---VYKVETIGDAYCVAGGLH-------KESDTHAVQIALMALKMMELS 560
Query: 1150 DDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVS 1209
D+ + K+R+G + G + AGV+G Y ++G+ V +A++ ++ V +I VS
Sbjct: 561 DEVMSPH-GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619
Query: 1210 EESYR 1214
+YR
Sbjct: 620 PTTYR 624
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 98.2 bits (243), Expect = 5e-20
Identities = 63/231 (27%), Positives = 123/231 (53%), Gaps = 11/231 (4%)
Query: 318 MHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKS---- 373
+H D+ + A ++ ++ V + A D +K+ ++ + +++R + + +KK
Sbjct: 438 LHLSDIPIHDATRDVIL--VGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLY 495
Query: 374 SIQKAPIAFRPFKMQQIE-----EVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDR 428
SI +A + ++ QQ++ +V++LF+DIVGFT + A + ++ +LN+L+ RFD
Sbjct: 496 SIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDH 555
Query: 429 LCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRV 488
C K+ T+GD Y AG HA M L M++ E+ + MR+
Sbjct: 556 QCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRI 615
Query: 489 GVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYL 539
G+H+G+VL G++G+R ++ ++ N+V LA+ E ++++S T + L
Sbjct: 616 GIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
Score = 60.8 bits (146), Expect = 8e-09
Identities = 55/210 (26%), Positives = 101/210 (48%), Gaps = 16/210 (7%)
Query: 1012 VEADLHRTK--IQSMRDQADWLLRNIIPYHVAEQL-KVSQTYSKNHDSGGVIFASIVNFS 1068
++A L RT ++ + + LL +I P VA+QL + Q ++ D ++F+ IV F+
Sbjct: 472 LKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFT 531
Query: 1069 EFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDG 1128
+ + +LNEL FD + I K++TIG Y A+GL+
Sbjct: 532 AICAQCTP--MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVAAGLHRKSLC-- 584
Query: 1129 SHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWG 1188
H + + A +MM + ++ ++R+G + G + AGV+G Y ++G
Sbjct: 585 -----HAKPIALMALKMMELSEEVLTPD-GRPIQMRIGIHSGSVLAGVVGVRMPRYCLFG 638
Query: 1189 DTVNIASRMDTTGVECRIQVSEESYRVLSK 1218
+ V +AS+ ++ RI VS +Y++L +
Sbjct: 639 NNVTLASKFESGSHPRRINVSPTTYQLLKR 668
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 94.0 bits (232), Expect = 9e-19
Identities = 70/228 (30%), Positives = 114/228 (50%), Gaps = 16/228 (7%)
Query: 1018 RTKI-QSMRDQADWLLRNIIPYHVAEQLKVSQTYSKN-HDSGGVIFASIVNFSEFYEENY 1075
RT++ ++ RD+AD L ++P V + LK ++ + F+ IV F+ + Y
Sbjct: 782 RTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICK--Y 839
Query: 1076 EGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHL 1135
E +LN++ FD ++ D+ + K++TIG YM ASGL H
Sbjct: 840 STPMEVVDMLNDIYKSFDHIV---DHHDVYKVETIGDAYMVASGLPKRNGN------RHA 890
Query: 1136 QILFEFAKEMMRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIA 1194
+ + A E++ + F ++ +R+G + GP AGV+G Y ++GDTVN A
Sbjct: 891 IDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTA 950
Query: 1195 SRMDTTGVECRIQVSEESYRVLSKMGYDFDY--RGTVNVKGKGQMKTY 1240
SRM++TG+ RI VS + +L + F Y RG +KG+G TY
Sbjct: 951 SRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTY 998
Score = 85.5 bits (210), Expect = 3e-16
Identities = 47/152 (30%), Positives = 85/152 (55%), Gaps = 3/152 (1%)
Query: 391 EEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG 450
EEV+I F+DIVGFT + + +V +LND++ FD + + K+ T+GD Y +G
Sbjct: 821 EEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASG 880
Query: 451 CPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKE--MVNMRVGVHTGTVLCGILGMRRFKF 507
P+ + HA +M L ++ + F E + +R+GVH+G G++G++ ++
Sbjct: 881 LPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRY 940
Query: 508 DVWSNDVNLANLMEQLGVAGKVHISEATAKYL 539
++ + VN A+ ME G+ ++H+S +T L
Sbjct: 941 CLFGDTVNTASRMESTGLPLRIHVSGSTIAIL 972
>gi|209976994 adenylate cyclase 10 [Homo sapiens]
Length = 1610
Score = 35.0 bits (79), Expect = 0.49
Identities = 25/81 (30%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Query: 442 GDCYYCVAGCP-EPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGIL 500
G + CV G P E D +E + + FC + ++ + +GV +G V CGI+
Sbjct: 341 GCSFLCVFGFPGEKVPDELTHALECAMDIF----DFCSQVHKIQTVSIGVASGIVFCGIV 396
Query: 501 GMR-RFKFDVWSNDVNLANLM 520
G R ++ V VNLA M
Sbjct: 397 GHTVRHEYTVIGQKVNLAARM 417
>gi|7657307 LIM domains containing 1 [Homo sapiens]
Length = 676
Score = 33.9 bits (76), Expect = 1.1
Identities = 25/61 (40%), Positives = 31/61 (50%), Gaps = 5/61 (8%)
Query: 42 HP-KHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNL 100
HP H + S+SSS SS G GG +GG R +K L+ ASS+ P S NL
Sbjct: 225 HPLNHRQLSLSSSRSSEGSLGGQNSGIGG----RSSEKPTGLWSTASSQRVSPGLPSPNL 280
Query: 101 E 101
E
Sbjct: 281 E 281
>gi|24797143 sorting nexin 14 isoform b [Homo sapiens]
Length = 893
Score = 33.1 bits (74), Expect = 1.9
Identities = 33/124 (26%), Positives = 56/124 (45%), Gaps = 25/124 (20%)
Query: 669 NPKTQNGLL------SPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIRE 722
+P T N LL SPP EK T + L LQ ++A + ++L L K IRE
Sbjct: 244 DPDTVNHLLIIFIDDSPP--EKATEPASPLVPFLQ---KFAEPRNKKPSVLKLELKQIRE 298
Query: 723 KTDA--HFVDVIKEDSLM------------KDYFFKPPINQFSLNFLDQELERSYRTSYQ 768
+ D F++ +K++ + D +P ++ + L +EL++ Y+T
Sbjct: 299 QQDLLFRFMNFLKQEGAVHVLQFCLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCL 358
Query: 769 EEVI 772
+E I
Sbjct: 359 DESI 362
>gi|24797145 sorting nexin 14 isoform a [Homo sapiens]
Length = 946
Score = 33.1 bits (74), Expect = 1.9
Identities = 33/124 (26%), Positives = 56/124 (45%), Gaps = 25/124 (20%)
Query: 669 NPKTQNGLL------SPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIRE 722
+P T N LL SPP EK T + L LQ ++A + ++L L K IRE
Sbjct: 288 DPDTVNHLLIIFIDDSPP--EKATEPASPLVPFLQ---KFAEPRNKKPSVLKLELKQIRE 342
Query: 723 KTDA--HFVDVIKEDSLM------------KDYFFKPPINQFSLNFLDQELERSYRTSYQ 768
+ D F++ +K++ + D +P ++ + L +EL++ Y+T
Sbjct: 343 QQDLLFRFMNFLKQEGAVHVLQFCLTVEEFNDRILRPELSNDEMLSLHEELQKIYKTYCL 402
Query: 769 EEVI 772
+E I
Sbjct: 403 DESI 406
>gi|53828698 olfactory receptor, family 13, subfamily G, member 1
[Homo sapiens]
Length = 307
Score = 32.0 bits (71), Expect = 4.1
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 5/109 (4%)
Query: 150 LCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTA 209
L FL+V + FL + A+ Y T L + VF LTLA ++ S
Sbjct: 26 LFFLIVYLVAFLGNMLIIIAKIYNNT-LHTPMYVFLLTLAV-VDIICTTSIIPKMLGTML 83
Query: 210 TARPTDT---CLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVL 255
T+ T + C+SQ+ F+ + +L+T M Y+++C + YS +
Sbjct: 84 TSENTISYAGCMSQLFLFTWSLGAEMVLFTTMAYDRYVAICFPLHYSTI 132
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 31.6 bits (70), Expect = 5.4
Identities = 29/87 (33%), Positives = 44/87 (50%), Gaps = 9/87 (10%)
Query: 344 DDLMKQGDEESENSVKRHATSSPKNRKKKSSIQK-APIAFRPFKMQQIE--EVSILFADI 400
DD + +EE E + +P RKK+ + QK AP A K Q++E E + F
Sbjct: 255 DDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEA----KKQKVEGTEPTTAFNLF 310
Query: 401 VGFTKMSANKSAHALVGLLNDLFGRFD 427
VG ++ NKSA L ++D+F + D
Sbjct: 311 VG--NLNFNKSAPELKTGISDVFAKND 335
>gi|212549782 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 31.2 bits (69), Expect = 7.1
Identities = 44/191 (23%), Positives = 76/191 (39%), Gaps = 28/191 (14%)
Query: 300 VMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGD-EESENSV 358
+ +QV FLK M D ++ K +H V + + + + EE +SV
Sbjct: 1619 IQTQVPDIYEFLKDASDKMGHSDEVADECFK---LHQVWETKVPESIEELPSMEEISHSV 1675
Query: 359 KRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGL 418
H ++ + + K P+ + + EV++L D +G + + N+SA L
Sbjct: 1676 GEHLPNTYVD------LTKDPVT-ETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNS 1728
Query: 419 LN-DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIE-MGLGMIKAIEQF 476
L D G F L ++ E S +H +E +G G+I+ E
Sbjct: 1729 LQADTVGAFIDLTQDASSEAKS---------------EGNHPALAVEDLGCGVIQVDEDN 1773
Query: 477 CQEKKEMVNMR 487
C+E+K V R
Sbjct: 1774 CKEEKAQVANR 1784
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,795,216
Number of Sequences: 37866
Number of extensions: 2267093
Number of successful extensions: 7413
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 7223
Number of HSP's gapped (non-prelim): 105
length of query: 1353
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1239
effective length of database: 13,930,794
effective search space: 17260253766
effective search space used: 17260253766
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.