Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4885631
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885631 tyrosine kinase with immunoglobulin-like and
EGF-like domains 1 [Homo sapiens]
(1138 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 2358 0.0
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 955 0.0
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 259 8e-69
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 259 8e-69
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 250 6e-66
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 250 6e-66
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 250 6e-66
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 250 6e-66
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 249 8e-66
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 249 8e-66
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 249 8e-66
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 249 1e-65
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 249 1e-65
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 244 3e-64
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 244 3e-64
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 244 3e-64
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 244 3e-64
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 244 3e-64
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 244 3e-64
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 244 3e-64
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 244 3e-64
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 244 3e-64
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 243 6e-64
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 219 2e-56
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 219 2e-56
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 219 2e-56
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 219 2e-56
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 219 2e-56
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 216 1e-55
gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens] 214 5e-55
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 2358 bits (6110), Expect = 0.0
Identities = 1138/1138 (100%), Positives = 1138/1138 (100%)
Query: 1 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP 60
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
Sbjct: 1 MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP 60
Query: 61 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH 120
LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
Sbjct: 61 LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH 120
Query: 121 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL 180
NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
Sbjct: 121 NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL 180
Query: 181 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH 240
QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
Sbjct: 181 QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH 240
Query: 241 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS 300
DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
Sbjct: 241 DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS 300
Query: 301 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL 360
QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
Sbjct: 301 QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL 360
Query: 361 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD 420
EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
Sbjct: 361 EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD 420
Query: 421 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV 480
SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
Sbjct: 421 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV 480
Query: 481 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT 540
RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
Sbjct: 481 RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT 540
Query: 541 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP 600
DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
Sbjct: 541 DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP 600
Query: 601 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI 660
QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
Sbjct: 601 QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI 660
Query: 661 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA 720
QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
Sbjct: 661 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA 720
Query: 721 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL 780
SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
Sbjct: 721 SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL 780
Query: 781 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT 840
LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
Sbjct: 781 LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT 840
Query: 841 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI 900
FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
Sbjct: 841 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI 900
Query: 901 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA 960
INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
Sbjct: 901 INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA 960
Query: 961 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM 1020
SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
Sbjct: 961 SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM 1020
Query: 1021 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD 1080
AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
Sbjct: 1021 AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD 1080
Query: 1081 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA 1138
EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
Sbjct: 1081 EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA 1138
>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
Length = 1124
Score = 955 bits (2469), Expect = 0.0
Identities = 529/1140 (46%), Positives = 697/1140 (61%), Gaps = 44/1140 (3%)
Query: 13 LFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGP--PLLLEKDDRIV 70
L L+ V A+DL L+ +L L LTC++ W P P+ + +D +
Sbjct: 14 LLLSGTVEGAMDLILINSLPLVSDAETSLTCIAS---------GWRPHEPITIGRDFEAL 64
Query: 71 RTPPGPPLRLARNGSHQVTLRGF---SKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHL 127
PL + ++ + + + K S + G + C G R+ + A
Sbjct: 65 MNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQQASF 124
Query: 128 LPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQP 187
LP +T TV+KGD +S + K+ D + NGS+ +++ HE D + LP+ QP
Sbjct: 125 LPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPD-ILEVHLPHAQP 183
Query: 188 PSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCP 247
+G+YSA Y+ + SAF RLIVR C A +WGP C C C++ GVCH+ GEC+CP
Sbjct: 184 QDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGECICP 243
Query: 248 PGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACA 307
PGF G CE+AC FG++C+E+C G GC+ FCLPDPYGCSC +GW+G QC EAC
Sbjct: 244 PGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNEACH 303
Query: 308 PGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSD---RIPQILNMASELEFNL 364
PG +G DC+L+C C NG CDRF GC+C GW G+ CE+ P+I+++ +E N
Sbjct: 304 PGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIEVNS 363
Query: 365 ETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFW 424
I C A+G P P + L KPDGTVL + A F + R++ DSG W
Sbjct: 364 GKFNPI-CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVW 422
Query: 425 ECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVS-PLVSFSGDGPISTVRLH 483
C V+T G + F ++VKV P PL AP ++ V++ + GDGPI + +L
Sbjct: 423 VCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLL 482
Query: 484 YRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCP 543
Y+P + W I V +E VTL L P+T Y + VQL R GEGGEG GP TT
Sbjct: 483 YKPVNHYEAWQHIQVT-NEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTT--- 538
Query: 544 EPLLQPWLEGWHV--EGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQ 601
+ P G ++ + L ++W P+ P D F + + + + ++N+ P
Sbjct: 539 ASIGLPPPRGLNLLPKSQTTLNLTWQ-PIFPSS--EDDFYVEVERRSVQKSDQQNIKVPG 595
Query: 602 ARTA-LLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI 660
T+ LL L P Y + ++ + L PP P ++ ++ S
Sbjct: 596 NLTSVLLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSA 655
Query: 661 QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTI--IRGLNASTRYLFRM 718
++W + IS + +V G D +DV T T ++GL T Y +
Sbjct: 656 VISWTILDGYS--ISSITIRYKVQGKNEDQ-HVDVKIKNATITQYQLKGLEPETAYQVDI 712
Query: 719 RASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILA 778
A +G SN L +++ P A+ G + L++A++GS TCLT+L
Sbjct: 713 FAE-NNIGS-SNPAFSHELVTLPESQAP------ADLGGGKMLLIAILGSAGMTCLTVLL 764
Query: 779 ALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWED 838
A L ++ ++R+ + RR +Q+ EE +QF+SGTL L R+ K P+P YPVL+W D
Sbjct: 765 AFLIILQLKRANVQRRMAQAFQNVR-EEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWND 823
Query: 839 ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHP 898
I F+D+IGEGNFGQV++A IKKDGL+M+AAIK +KEYAS++DHRDFAGELEVLCKLGHHP
Sbjct: 824 IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHP 883
Query: 899 NIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLR 958
NIINLLGAC++RGYLY+AIEYAP+GNLLDFLRKSRVLETDPAFA + TASTLSS+QLL
Sbjct: 884 NIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLH 943
Query: 959 FASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVR 1018
FA+D A GM YLS+KQFIHRDLAARN+LVGEN +KIADFGLSRG+EVYVKKTMGRLPVR
Sbjct: 944 FAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVR 1003
Query: 1019 WMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNC 1078
WMAIESLNYSVYTT SDVWS+GVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR+E+P NC
Sbjct: 1004 WMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNC 1063
Query: 1079 DDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA 1138
DDEVY+LMRQCWR++PYERP FAQI + L RMLE RK YVN +L+E FTYAGID +AEEA
Sbjct: 1064 DDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEA 1123
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 259 bits (663), Expect = 8e-69
Identities = 158/389 (40%), Positives = 225/389 (57%), Gaps = 43/389 (11%)
Query: 773 CLTILAA-----LLTLVCIRRSCLHRRRTFTYQS--GSGEETILQFS-----SGTLTLTR 820
C T++AA + V + C+H F ++ S E T + + S + + R
Sbjct: 634 CRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGAR 693
Query: 821 RPKL-----QPEPLSYPVLE---WE----DITFEDLIGEGNFGQVIRAM---IKKDGLKM 865
RP L Q ++ +LE WE ++ +GEG FG+V++A +K
Sbjct: 694 RPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT 753
Query: 866 NAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNL 925
A+KMLKE AS ++ RD E VL K +HP++I L GAC G L + +EYA YG+L
Sbjct: 754 TVAVKMLKENASPSELRDLLSEFNVL-KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL 812
Query: 926 LDFLRKSRVLETDPAF----------AREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975
FLR+SR + P + + +H L+ L+ FA + GMQYL+E +
Sbjct: 813 RGFLRESR--KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL 870
Query: 976 IHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTT 1032
+HRDLAARN+LV E KI+DFGLSR E+ YVK++ GR+PV+WMAIESL +YTT
Sbjct: 871 VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTT 930
Query: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092
+SDVWSFGVLLWEIV+LGG PY G+ L+ L G+RME+P NC +E+Y LM QCW+
Sbjct: 931 QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ 990
Query: 1093 RPYERPPFAQIALQLGRMLEARKAYVNMS 1121
P +RP FA I+ L +M+ R+ Y++++
Sbjct: 991 EPDKRPVFADISKDLEKMMVKRRDYLDLA 1019
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 259 bits (663), Expect = 8e-69
Identities = 158/389 (40%), Positives = 225/389 (57%), Gaps = 43/389 (11%)
Query: 773 CLTILAA-----LLTLVCIRRSCLHRRRTFTYQS--GSGEETILQFS-----SGTLTLTR 820
C T++AA + V + C+H F ++ S E T + + S + + R
Sbjct: 634 CRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGAR 693
Query: 821 RPKL-----QPEPLSYPVLE---WE----DITFEDLIGEGNFGQVIRAM---IKKDGLKM 865
RP L Q ++ +LE WE ++ +GEG FG+V++A +K
Sbjct: 694 RPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT 753
Query: 866 NAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNL 925
A+KMLKE AS ++ RD E VL K +HP++I L GAC G L + +EYA YG+L
Sbjct: 754 TVAVKMLKENASPSELRDLLSEFNVL-KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL 812
Query: 926 LDFLRKSRVLETDPAF----------AREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975
FLR+SR + P + + +H L+ L+ FA + GMQYL+E +
Sbjct: 813 RGFLRESR--KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL 870
Query: 976 IHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTT 1032
+HRDLAARN+LV E KI+DFGLSR E+ YVK++ GR+PV+WMAIESL +YTT
Sbjct: 871 VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTT 930
Query: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092
+SDVWSFGVLLWEIV+LGG PY G+ L+ L G+RME+P NC +E+Y LM QCW+
Sbjct: 931 QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ 990
Query: 1093 RPYERPPFAQIALQLGRMLEARKAYVNMS 1121
P +RP FA I+ L +M+ R+ Y++++
Sbjct: 991 EPDKRPVFADISKDLEKMMVKRRDYLDLA 1019
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 250 bits (638), Expect = 6e-66
Identities = 137/288 (47%), Positives = 185/288 (64%), Gaps = 10/288 (3%)
Query: 845 IGEGNFGQVIRA-MIKKDGLKMN----AAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
+GEG FGQV+ A I D K N A+KMLK A+E D D E+E++ +G H N
Sbjct: 393 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 452
Query: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
IINLLGAC G LY+ +EYA GNL ++L+ R + + H LSS+ L+
Sbjct: 453 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 512
Query: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLP 1016
A A GM+YL+ K+ IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLP
Sbjct: 513 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 572
Query: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPR 1076
V+WMA E+L +YT +SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P
Sbjct: 573 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 632
Query: 1077 NCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMSL 1122
NC +E+Y +MR CW P +RP F Q+ L R+ L + + Y+++S+
Sbjct: 633 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM 680
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 250 bits (638), Expect = 6e-66
Identities = 137/288 (47%), Positives = 185/288 (64%), Gaps = 10/288 (3%)
Query: 845 IGEGNFGQVIRA-MIKKDGLKMN----AAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
+GEG FGQV+ A I D K N A+KMLK A+E D D E+E++ +G H N
Sbjct: 395 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 454
Query: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
IINLLGAC G LY+ +EYA GNL ++L+ R + + H LSS+ L+
Sbjct: 455 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 514
Query: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLP 1016
A A GM+YL+ K+ IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLP
Sbjct: 515 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 574
Query: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPR 1076
V+WMA E+L +YT +SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P
Sbjct: 575 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 634
Query: 1077 NCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMSL 1122
NC +E+Y +MR CW P +RP F Q+ L R+ L + + Y+++S+
Sbjct: 635 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM 682
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 250 bits (638), Expect = 6e-66
Identities = 137/288 (47%), Positives = 185/288 (64%), Gaps = 10/288 (3%)
Query: 845 IGEGNFGQVIRA-MIKKDGLKMN----AAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
+GEG FGQV+ A I D K N A+KMLK A+E D D E+E++ +G H N
Sbjct: 482 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 541
Query: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
IINLLGAC G LY+ +EYA GNL ++L+ R + + H LSS+ L+
Sbjct: 542 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 601
Query: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLP 1016
A A GM+YL+ K+ IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLP
Sbjct: 602 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 661
Query: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPR 1076
V+WMA E+L +YT +SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P
Sbjct: 662 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 721
Query: 1077 NCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMSL 1122
NC +E+Y +MR CW P +RP F Q+ L R+ L + + Y+++S+
Sbjct: 722 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM 769
Score = 32.3 bits (72), Expect = 2.6
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 407 TTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNV 443
T E EV V ADSG + C S+ G D+ F VNV
Sbjct: 82 TGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV 118
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 250 bits (638), Expect = 6e-66
Identities = 137/288 (47%), Positives = 185/288 (64%), Gaps = 10/288 (3%)
Query: 845 IGEGNFGQVIRA-MIKKDGLKMN----AAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
+GEG FGQV+ A I D K N A+KMLK A+E D D E+E++ +G H N
Sbjct: 484 LGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKN 543
Query: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
IINLLGAC G LY+ +EYA GNL ++L+ R + + H LSS+ L+
Sbjct: 544 IINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSC 603
Query: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLP 1016
A A GM+YL+ K+ IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLP
Sbjct: 604 AYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLP 663
Query: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPR 1076
V+WMA E+L +YT +SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P
Sbjct: 664 VKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPS 723
Query: 1077 NCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMSL 1122
NC +E+Y +MR CW P +RP F Q+ L R+ L + + Y+++S+
Sbjct: 724 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSM 771
Score = 32.3 bits (72), Expect = 2.6
Identities = 17/37 (45%), Positives = 20/37 (54%)
Query: 407 TTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNV 443
T E EV V ADSG + C S+ G D+ F VNV
Sbjct: 82 TGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV 118
>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
[Homo sapiens]
Length = 808
Score = 249 bits (637), Expect = 8e-66
Identities = 150/349 (42%), Positives = 206/349 (59%), Gaps = 24/349 (6%)
Query: 808 ILQFSSG---TLTLTRRPKLQPEPLSYPVLEWE----DITFEDLIGEGNFGQVIRAM--- 857
I + SSG TL +L +P +WE +T +GEG FGQV+ A
Sbjct: 442 IARLSSGEGPTLANVSELELPADP------KWELSRARLTLGKPLGEGCFGQVVMAEAIG 495
Query: 858 IKKD--GLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYI 915
I KD + A+KMLK+ A++ D D E+E++ +G H NIINLLGAC G LY+
Sbjct: 496 IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 555
Query: 916 AIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975
+EYA GNL +FLR R D +F L+ + L+ A A GM+YL+ ++
Sbjct: 556 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 615
Query: 976 IHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRWMAIESLNYSVYTT 1032
IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLPV+WMA E+L VYT
Sbjct: 616 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 675
Query: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092
+SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P NC ++Y +MR+CW
Sbjct: 676 QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA 735
Query: 1093 RPYERPPFAQIALQLGRMLEARKA--YVNMSL-FENFTYAGIDATAEEA 1138
P +RP F Q+ L R+L Y+++S FE ++ G D + +
Sbjct: 736 APSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSS 784
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 249 bits (637), Expect = 8e-66
Identities = 150/349 (42%), Positives = 206/349 (59%), Gaps = 24/349 (6%)
Query: 808 ILQFSSG---TLTLTRRPKLQPEPLSYPVLEWE----DITFEDLIGEGNFGQVIRAM--- 857
I + SSG TL +L +P +WE +T +GEG FGQV+ A
Sbjct: 328 IARLSSGEGPTLANVSELELPADP------KWELSRARLTLGKPLGEGCFGQVVMAEAIG 381
Query: 858 IKKD--GLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYI 915
I KD + A+KMLK+ A++ D D E+E++ +G H NIINLLGAC G LY+
Sbjct: 382 IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 441
Query: 916 AIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975
+EYA GNL +FLR R D +F L+ + L+ A A GM+YL+ ++
Sbjct: 442 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 501
Query: 976 IHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRWMAIESLNYSVYTT 1032
IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLPV+WMA E+L VYT
Sbjct: 502 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 561
Query: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092
+SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P NC ++Y +MR+CW
Sbjct: 562 QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA 621
Query: 1093 RPYERPPFAQIALQLGRMLEARKA--YVNMSL-FENFTYAGIDATAEEA 1138
P +RP F Q+ L R+L Y+++S FE ++ G D + +
Sbjct: 622 APSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSS 670
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 249 bits (637), Expect = 8e-66
Identities = 150/349 (42%), Positives = 206/349 (59%), Gaps = 24/349 (6%)
Query: 808 ILQFSSG---TLTLTRRPKLQPEPLSYPVLEWE----DITFEDLIGEGNFGQVIRAM--- 857
I + SSG TL +L +P +WE +T +GEG FGQV+ A
Sbjct: 440 IARLSSGEGPTLANVSELELPADP------KWELSRARLTLGKPLGEGCFGQVVMAEAIG 493
Query: 858 IKKD--GLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYI 915
I KD + A+KMLK+ A++ D D E+E++ +G H NIINLLGAC G LY+
Sbjct: 494 IDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 553
Query: 916 AIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975
+EYA GNL +FLR R D +F L+ + L+ A A GM+YL+ ++
Sbjct: 554 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKC 613
Query: 976 IHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRWMAIESLNYSVYTT 1032
IHRDLAARNVLV E+ KIADFGL+R + Y K T GRLPV+WMA E+L VYT
Sbjct: 614 IHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTH 673
Query: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092
+SDVWSFGVLLWEI +LGG+PY G+ EL++ L +G+RM++P NC ++Y +MR+CW
Sbjct: 674 QSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHA 733
Query: 1093 RPYERPPFAQIALQLGRMLEARKA--YVNMSL-FENFTYAGIDATAEEA 1138
P +RP F Q+ L R+L Y+++S FE ++ G D + +
Sbjct: 734 APSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSS 782
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 249 bits (636), Expect = 1e-65
Identities = 164/418 (39%), Positives = 227/418 (54%), Gaps = 39/418 (9%)
Query: 752 AAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRR----------------- 794
AA E +IL GS++ L +LA L R LH R
Sbjct: 361 AAPEARYTDIILYASGSLALAVLLLLAGLY-----RGQALHGRHPRPPATVQKLSRFPLA 415
Query: 795 RTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSY-----PVLEW--EDITFEDLIGE 847
R F+ +SGS ++ G + P L +S P+ E+ + + +GE
Sbjct: 416 RQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGE 475
Query: 848 GNFGQVIRAMI-----KKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIIN 902
G FGQV+RA + A+KMLK+ AS+ D D E+EV+ +G H NIIN
Sbjct: 476 GCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIIN 535
Query: 903 LLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASD 962
LLG C G LY+ +E A GNL +FLR R D + + LS L+ A
Sbjct: 536 LLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQ 595
Query: 963 AANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRW 1019
A GMQYL ++ IHRDLAARNVLV E+ KIADFGL+RG + Y K + GRLPV+W
Sbjct: 596 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW 655
Query: 1020 MAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCD 1079
MA E+L VYT +SDVWSFG+LLWEI +LGG+PY G+ EL+ L +G+RM++P +C
Sbjct: 656 MAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP 715
Query: 1080 DEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA-RKAYVNMSL-FENFTYAGIDATA 1135
E+Y LMR+CW P +RP F Q+ L ++L A + Y+++ L F ++ +G DA++
Sbjct: 716 PELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASS 773
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 249 bits (636), Expect = 1e-65
Identities = 164/418 (39%), Positives = 227/418 (54%), Gaps = 39/418 (9%)
Query: 752 AAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRR----------------- 794
AA E +IL GS++ L +LA L R LH R
Sbjct: 361 AAPEARYTDIILYASGSLALAVLLLLAGLY-----RGQALHGRHPRPPATVQKLSRFPLA 415
Query: 795 RTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSY-----PVLEW--EDITFEDLIGE 847
R F+ +SGS ++ G + P L +S P+ E+ + + +GE
Sbjct: 416 RQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGE 475
Query: 848 GNFGQVIRAMI-----KKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIIN 902
G FGQV+RA + A+KMLK+ AS+ D D E+EV+ +G H NIIN
Sbjct: 476 GCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIIN 535
Query: 903 LLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASD 962
LLG C G LY+ +E A GNL +FLR R D + + LS L+ A
Sbjct: 536 LLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQ 595
Query: 963 AANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLPVRW 1019
A GMQYL ++ IHRDLAARNVLV E+ KIADFGL+RG + Y K + GRLPV+W
Sbjct: 596 VARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKW 655
Query: 1020 MAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCD 1079
MA E+L VYT +SDVWSFG+LLWEI +LGG+PY G+ EL+ L +G+RM++P +C
Sbjct: 656 MAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP 715
Query: 1080 DEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA-RKAYVNMSL-FENFTYAGIDATA 1135
E+Y LMR+CW P +RP F Q+ L ++L A + Y+++ L F ++ +G DA++
Sbjct: 716 PELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASS 773
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 244 bits (624), Expect = 3e-64
Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)
Query: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 362 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 421
Query: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 422 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 481
Query: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 482 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 541
Query: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 542 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 601
Query: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+ L + Y+++S
Sbjct: 602 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 656
>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
[Homo sapiens]
Length = 705
Score = 244 bits (624), Expect = 3e-64
Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)
Query: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 363 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 422
Query: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 423 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 482
Query: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 483 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 542
Query: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 543 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 602
Query: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+ L + Y+++S
Sbjct: 603 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 657
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 244 bits (624), Expect = 3e-64
Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)
Query: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 364 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 423
Query: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 424 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 483
Query: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 484 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 543
Query: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 544 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 603
Query: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+ L + Y+++S
Sbjct: 604 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 658
>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
[Homo sapiens]
Length = 709
Score = 244 bits (624), Expect = 3e-64
Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)
Query: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 367 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 426
Query: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 427 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 486
Query: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 487 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 546
Query: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 547 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 606
Query: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+ L + Y+++S
Sbjct: 607 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 661
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 244 bits (624), Expect = 3e-64
Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)
Query: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 479 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 538
Query: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 539 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 598
Query: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 599 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 658
Query: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 659 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 718
Query: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+ L + Y+++S
Sbjct: 719 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 773
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 244 bits (624), Expect = 3e-64
Identities = 134/295 (45%), Positives = 186/295 (63%), Gaps = 10/295 (3%)
Query: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 480 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 539
Query: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 540 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 599
Query: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 600 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 659
Query: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 660 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 719
Query: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRM--LEARKAYVNMS 1121
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+ L + Y+++S
Sbjct: 720 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLS 774
>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
[Homo sapiens]
Length = 680
Score = 244 bits (623), Expect = 3e-64
Identities = 132/283 (46%), Positives = 180/283 (63%), Gaps = 8/283 (2%)
Query: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 391 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 450
Query: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 451 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 510
Query: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 511 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 570
Query: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 571 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 630
Query: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+L
Sbjct: 631 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 244 bits (623), Expect = 3e-64
Identities = 132/283 (46%), Positives = 180/283 (63%), Gaps = 8/283 (2%)
Query: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 480 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 539
Query: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 540 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 599
Query: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 600 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 659
Query: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 660 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 719
Query: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+L
Sbjct: 720 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762
>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
[Homo sapiens]
Length = 707
Score = 244 bits (623), Expect = 3e-64
Identities = 132/283 (46%), Positives = 180/283 (63%), Gaps = 8/283 (2%)
Query: 837 EDITFEDLIGEGNFGQVIRAM---IKKDGLK--MNAAIKMLKEYASENDHRDFAGELEVL 891
+ +T +GEG FGQV+ A I KD K + A+KMLK+ A+E D D E+E++
Sbjct: 390 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMM 449
Query: 892 CKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTL 951
+G H NIINLLGAC G LY+ +EYA GNL ++LR R + ++ +
Sbjct: 450 KMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM 509
Query: 952 SSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---GEEVYV 1008
+ + L+ A GM+YL+ ++ IHRDLAARNVLV EN KIADFGL+R + Y
Sbjct: 510 TFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK 569
Query: 1009 KKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1068
K T GRLPV+WMA E+L VYT +SDVWSFGVL+WEI +LGG+PY G+ EL++ L +
Sbjct: 570 KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE 629
Query: 1069 GYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111
G+RM++P NC +E+Y +MR CW P +RP F Q+ L R+L
Sbjct: 630 GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 243 bits (621), Expect = 6e-64
Identities = 138/301 (45%), Positives = 187/301 (62%), Gaps = 10/301 (3%)
Query: 845 IGEGNFGQVIRAMI-----KKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPN 899
+GEG FGQV+RA + A+KMLK+ AS+ D D E+EV+ +G H N
Sbjct: 433 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 492
Query: 900 IINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRF 959
IINLLG C G LY+ +E A GNL +FLR R D + + LS L+
Sbjct: 493 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 552
Query: 960 ASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGE---EVYVKKTMGRLP 1016
A A GMQYL ++ IHRDLAARNVLV E+ KIADFGL+RG + Y K + GRLP
Sbjct: 553 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 612
Query: 1017 VRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPR 1076
V+WMA E+L VYT +SDVWSFG+LLWEI +LGG+PY G+ EL+ L +G+RM++P
Sbjct: 613 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 672
Query: 1077 NCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA-RKAYVNMSL-FENFTYAGIDAT 1134
+C E+Y LMR+CW P +RP F Q+ L ++L A + Y+++ L F ++ +G DA+
Sbjct: 673 HCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDAS 732
Query: 1135 A 1135
+
Sbjct: 733 S 733
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 219 bits (557), Expect = 2e-56
Identities = 122/271 (45%), Positives = 165/271 (60%), Gaps = 21/271 (7%)
Query: 834 LEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
+E DIT + +G G +G+V + KK L + A+K LKE E + +F E V+ +
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTV--AVKTLKEDTMEVE--EFLKEAAVMKE 323
Query: 894 LGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSS 953
+ HPN++ LLG C YI EY PYGNLLD+LR+ RE TA L
Sbjct: 324 I-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECN---------REEVTAVVL-- 371
Query: 954 RQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR--GEEVYVKKT 1011
L A+ ++ M+YL +K FIHRDLAARN LVGEN K+ADFGLSR + Y
Sbjct: 372 ---LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA 428
Query: 1012 MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 1071
+ P++W A ESL Y+ ++ KSDVW+FGVLLWEI + G +PY G+ +++Y+ L +GYR
Sbjct: 429 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 488
Query: 1072 MEQPRNCDDEVYELMRQCWRDRPYERPPFAQ 1102
MEQP C +VYELMR CW+ P +RP FA+
Sbjct: 489 MEQPEGCPPKVYELMRACWKWSPADRPSFAE 519
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 219 bits (557), Expect = 2e-56
Identities = 122/271 (45%), Positives = 165/271 (60%), Gaps = 21/271 (7%)
Query: 834 LEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
+E DIT + +G G +G+V + KK L + A+K LKE E + +F E V+ +
Sbjct: 283 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTV--AVKTLKEDTMEVE--EFLKEAAVMKE 338
Query: 894 LGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSS 953
+ HPN++ LLG C YI EY PYGNLLD+LR+ RE TA L
Sbjct: 339 I-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECN---------REEVTAVVL-- 386
Query: 954 RQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR--GEEVYVKKT 1011
L A+ ++ M+YL +K FIHRDLAARN LVGEN K+ADFGLSR + Y
Sbjct: 387 ---LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA 443
Query: 1012 MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 1071
+ P++W A ESL Y+ ++ KSDVW+FGVLLWEI + G +PY G+ +++Y+ L +GYR
Sbjct: 444 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 503
Query: 1072 MEQPRNCDDEVYELMRQCWRDRPYERPPFAQ 1102
MEQP C +VYELMR CW+ P +RP FA+
Sbjct: 504 MEQPEGCPPKVYELMRACWKWSPADRPSFAE 534
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 219 bits (557), Expect = 2e-56
Identities = 122/271 (45%), Positives = 165/271 (60%), Gaps = 21/271 (7%)
Query: 834 LEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
+E DIT + +G G +G+V + KK L + A+K LKE E + +F E V+ +
Sbjct: 262 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTV--AVKTLKEDTMEVE--EFLKEAAVMKE 317
Query: 894 LGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSS 953
+ HPN++ LLG C YI EY PYGNLLD+LR+ RE TA L
Sbjct: 318 I-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECN---------REEVTAVVL-- 365
Query: 954 RQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR--GEEVYVKKT 1011
L A+ ++ M+YL +K FIHRDLAARN LVGEN K+ADFGLSR + Y
Sbjct: 366 ---LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA 422
Query: 1012 MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 1071
+ P++W A ESL Y+ ++ KSDVW+FGVLLWEI + G +PY G+ +++Y+ L +GYR
Sbjct: 423 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 482
Query: 1072 MEQPRNCDDEVYELMRQCWRDRPYERPPFAQ 1102
MEQP C +VYELMR CW+ P +RP FA+
Sbjct: 483 MEQPEGCPPKVYELMRACWKWSPADRPSFAE 513
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 219 bits (557), Expect = 2e-56
Identities = 122/271 (45%), Positives = 165/271 (60%), Gaps = 21/271 (7%)
Query: 834 LEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
+E DIT + +G G +G+V + KK L + A+K LKE E + +F E V+ +
Sbjct: 268 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTV--AVKTLKEDTMEVE--EFLKEAAVMKE 323
Query: 894 LGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSS 953
+ HPN++ LLG C YI EY PYGNLLD+LR+ RE TA L
Sbjct: 324 I-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECN---------REEVTAVVL-- 371
Query: 954 RQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR--GEEVYVKKT 1011
L A+ ++ M+YL +K FIHRDLAARN LVGEN K+ADFGLSR + Y
Sbjct: 372 ---LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA 428
Query: 1012 MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 1071
+ P++W A ESL Y+ ++ KSDVW+FGVLLWEI + G +PY G+ +++Y+ L +GYR
Sbjct: 429 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 488
Query: 1072 MEQPRNCDDEVYELMRQCWRDRPYERPPFAQ 1102
MEQP C +VYELMR CW+ P +RP FA+
Sbjct: 489 MEQPEGCPPKVYELMRACWKWSPADRPSFAE 519
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 219 bits (557), Expect = 2e-56
Identities = 122/271 (45%), Positives = 165/271 (60%), Gaps = 21/271 (7%)
Query: 834 LEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCK 893
+E DIT + +G G +G+V + KK L + A+K LKE E + +F E V+ +
Sbjct: 247 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTV--AVKTLKEDTMEVE--EFLKEAAVMKE 302
Query: 894 LGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSS 953
+ HPN++ LLG C YI EY PYGNLLD+LR+ RE TA L
Sbjct: 303 I-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECN---------REEVTAVVL-- 350
Query: 954 RQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR--GEEVYVKKT 1011
L A+ ++ M+YL +K FIHRDLAARN LVGEN K+ADFGLSR + Y
Sbjct: 351 ---LYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHA 407
Query: 1012 MGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 1071
+ P++W A ESL Y+ ++ KSDVW+FGVLLWEI + G +PY G+ +++Y+ L +GYR
Sbjct: 408 GAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYR 467
Query: 1072 MEQPRNCDDEVYELMRQCWRDRPYERPPFAQ 1102
MEQP C +VYELMR CW+ P +RP FA+
Sbjct: 468 MEQPEGCPPKVYELMRACWKWSPADRPSFAE 498
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 216 bits (550), Expect = 1e-55
Identities = 120/302 (39%), Positives = 178/302 (58%), Gaps = 26/302 (8%)
Query: 808 ILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNA 867
++ SG + L PK + LS+ ED+ +L+G+GNFG+V + +K K +
Sbjct: 537 VITKKSGVVLLNPIPKDKKWILSH-----EDVILGELLGKGNFGEVYKGTLKD---KTSV 588
Query: 868 AIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLD 927
A+K KE + F E ++L K HPNI+ L+G C R +YI +E G+ L
Sbjct: 589 AVKTCKEDLPQELKIKFLQEAKIL-KQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLT 647
Query: 928 FLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLV 987
FLR+ + L +QL++F+ DAA GM YL K IHRDLAARN LV
Sbjct: 648 FLRRKK---------------DELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLV 692
Query: 988 GENLASKIADFGLSRGEE--VYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWE 1045
GEN KI+DFG+SR E+ VY + ++P++W A E+LNY Y+++SDVWSFG+LLWE
Sbjct: 693 GENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWE 752
Query: 1046 IVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIAL 1105
SLG PY GMT + E++ +GYRM P++C +++ ++M +CW +P RP F+++
Sbjct: 753 TFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQK 812
Query: 1106 QL 1107
+L
Sbjct: 813 EL 814
>gi|27597078 TYRO3 protein tyrosine kinase [Homo sapiens]
Length = 890
Score = 214 bits (544), Expect = 5e-55
Identities = 170/540 (31%), Positives = 261/540 (48%), Gaps = 63/540 (11%)
Query: 604 TALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSG---PPAPRHLHAQALSDSEI 660
T LL L P T+Y L V+ + LGP+ V G AP++LHA +DS +
Sbjct: 282 TCLLRDLVPATNYSLRVRCANA--LGPSPYADWVPFQTKGLAPASAPQNLHA-IRTDSGL 338
Query: 661 QLTWKH--PEA-LPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFR 717
L W+ PEA L GP+ Y + G D L + E T + G + + R
Sbjct: 339 ILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTV-----EGTRANLTGWDPQKDLIVR 393
Query: 718 MRAS-IQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTI 776
+ S G G WS + S+ RA ++G V + +
Sbjct: 394 VCVSNAVGCGPWSQPLVVSS------------HDRAGQQGPPHSRTSWVPVVLGVLTALV 441
Query: 777 LAALLTLVCIRRSCLHRR--RTFTYQSGSGEETILQFSSGTLTLTRRPKLQP-------- 826
AA L L+ +R+ R + F GE + ++ + R +++
Sbjct: 442 TAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGIS 501
Query: 827 ----EPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKK-DGLKMNAAIKMLK-EYASEND 880
E L ++ + T ++G+G FG V A +K+ DG + A+KMLK + + +D
Sbjct: 502 DELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSD 561
Query: 881 HRDFAGELEVLCKLGHHPNIINLLGAC---KNRGYLYIAIEYAPY---GNLLDFLRKSRV 934
+F E + K HP++ L+G + +G L I + P+ G+L FL SR+
Sbjct: 562 IEEFLREAACM-KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRI 620
Query: 935 LETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASK 994
E L + L+RF D A GM+YLS + FIHRDLAARN ++ E++
Sbjct: 621 GENP----------FNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVC 670
Query: 995 IADFGLSR---GEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGG 1051
+ADFGLSR + Y + +LPV+W+A+ESL ++YT +SDVW+FGV +WEI++ G
Sbjct: 671 VADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQ 730
Query: 1052 TPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111
TPY G+ AE+Y L G R++QP C ++VY+LM QCW P +RP F + ++L +L
Sbjct: 731 TPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENIL 790
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,553,596
Number of Sequences: 37866
Number of extensions: 2795119
Number of successful extensions: 14448
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 647
Number of HSP's successfully gapped in prelim test: 594
Number of HSP's that attempted gapping in prelim test: 7699
Number of HSP's gapped (non-prelim): 3915
length of query: 1138
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1025
effective length of database: 13,968,660
effective search space: 14317876500
effective search space used: 14317876500
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.