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Search of human proteins with 13375983
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
(323 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 632 0.0
gi|13899342 solute carrier [Homo sapiens] 402 e-112
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 214 8e-56
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 213 2e-55
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 213 2e-55
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 118 8e-27
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 114 2e-25
gi|13775208 solute carrier family 25 (mitochondrial carrier; ade... 109 3e-24
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 105 4e-23
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 105 7e-23
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 93 3e-19
gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 92 6e-19
gi|156071462 solute carrier family 25, member A6 [Homo sapiens] 91 2e-18
gi|115430257 solute carrier family 25, member 26 [Homo sapiens] 91 2e-18
gi|45237193 solute carrier family 25, member 44 isoform 1 [Homo ... 89 5e-18
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 89 5e-18
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 87 2e-17
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 87 2e-17
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 86 6e-17
gi|13259543 solute carrier family 25, member 14 isoform UCP5S [H... 86 6e-17
gi|55749577 solute carrier family 25 (mitochondrial carrier; ade... 85 8e-17
gi|116235466 solute carrier family 25, member 45 isoform b [Homo... 83 4e-16
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 83 4e-16
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 83 4e-16
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 82 5e-16
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 82 5e-16
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 82 5e-16
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 82 5e-16
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 82 5e-16
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 82 5e-16
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 632 bits (1629), Expect = 0.0
Identities = 323/323 (100%), Positives = 323/323 (100%)
Query: 1 MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSE 60
MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSE
Sbjct: 1 MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSE 60
Query: 61 GYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIV 120
GYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIV
Sbjct: 61 GYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIV 120
Query: 121 TTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRS 180
TTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRS
Sbjct: 121 TTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRS 180
Query: 181 RGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAA 240
RGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAA
Sbjct: 181 RGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAA 240
Query: 241 VAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFG 300
VAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFG
Sbjct: 241 VAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFG 300
Query: 301 IAQVVYFLGIAESLLGLLQDPQA 323
IAQVVYFLGIAESLLGLLQDPQA
Sbjct: 301 IAQVVYFLGIAESLLGLLQDPQA 323
>gi|13899342 solute carrier [Homo sapiens]
Length = 315
Score = 402 bits (1034), Expect = e-112
Identities = 208/317 (65%), Positives = 249/317 (78%), Gaps = 8/317 (2%)
Query: 1 MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSE 60
M + +S+ AKLINGG+AGL+GVTCVFPIDLAKTRLQNQ +G+ +Y M DCL+KT R+E
Sbjct: 1 MTHQDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQ-HGKAMYKGMIDCLMKTARAE 59
Query: 61 GYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIV 120
G+FGMYRGAAVNLTLVTPEKAIKLAANDFFR L +DG + L EMLAGCGAG CQV+V
Sbjct: 60 GFFGMYRGAAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKMEMLAGCGAGMCQVVV 119
Query: 121 TTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAP--RPTATQLTRDLL 178
T PMEMLKIQLQDAGR+A QG SA ++ A+ RP+AT + +LL
Sbjct: 120 TCPMEMLKIQLQDAGRLAVHH-----QGSASAPSTSRSYTTGSASTHRRPSATLIAWELL 174
Query: 179 RSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSA 238
R++G+AGLY+GLGATLLRD+PFS++YFPLFANLN LG K+ F SF++GCVAGS
Sbjct: 175 RTQGLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSFVSGCVAGSI 234
Query: 239 AAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPL 298
AAVAV P DV+KTR+Q+L++G+ ED YSGI DCARK+ EGPSAF+KGA CRALVIAPL
Sbjct: 235 AAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKGAGCRALVIAPL 294
Query: 299 FGIAQVVYFLGIAESLL 315
FGIAQ VYF+GI E +L
Sbjct: 295 FGIAQGVYFIGIGERIL 311
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 214 bits (545), Expect = 8e-56
Identities = 132/300 (44%), Positives = 168/300 (56%), Gaps = 38/300 (12%)
Query: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQN-----GQRVYTSMSDCLIKTVRSEGYFGMYRGA 69
G +AG +G T V+PIDL KTR+QNQ+ G+ +Y + DC K +R EG+FG+YRG
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL 392
Query: 70 AVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKI 129
L V PEKAIKL NDF R + ++ + L E+LAG AG QVI T P+E++KI
Sbjct: 393 IPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKI 452
Query: 130 QLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKG 189
+LQ AG I PR +A + RDL GI GLYKG
Sbjct: 453 RLQVAGEIT-------------------------TGPRVSALNVLRDL----GIFGLYKG 483
Query: 190 LGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFL-AGCVAGSAAAVAVNPCDV 248
A LRD+PFS +YFP++A+ L A E ++ L AG +AG AA V P DV
Sbjct: 484 AKACFLRDIPFSAIYFPVYAHCKLL--LADENGHVGGLNLLAAGAMAGVPAASLVTPADV 541
Query: 249 VKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFL 308
+KTRLQ R + TYSG++DC RKILR EGPSAF KG R +P FG+ V Y L
Sbjct: 542 IKTRLQVAAR-AGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYEL 600
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/141 (34%), Positives = 67/141 (47%), Gaps = 17/141 (12%)
Query: 171 TQLTRDLLRSRGIAGLYKGLGATLLRDV----PFSVVYFPL-FANLNQ-----LGRPASE 220
T L D+L +A LY G L D+ P + P A L + LGRP
Sbjct: 264 TPLEIDILYQ--LADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWL 321
Query: 221 EKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRG----VNEDTYSGILDCARKIL 276
+ + F G VAG+ A AV P D+VKTR+Q+ QRG V E Y DC +K+L
Sbjct: 322 QIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQN-QRGSGSVVGELMYKNSFDCFKKVL 380
Query: 277 RHEGPSAFLKGAYCRALVIAP 297
R+EG +G + + +AP
Sbjct: 381 RYEGFFGLYRGLIPQLIGVAP 401
Score = 55.1 bits (131), Expect = 8e-08
Identities = 51/186 (27%), Positives = 81/186 (43%), Gaps = 13/186 (6%)
Query: 3 DKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGY 62
D + LPA+++ GG AG V P+++ K RL Q + T + +R G
Sbjct: 421 DGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRL---QVAGEITTGPRVSALNVLRDLGI 477
Query: 63 FGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTT 122
FG+Y+GA P AI + L+ + + L + AG AG + T
Sbjct: 478 FGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVT 537
Query: 123 PMEMLKIQLQDAGR---------IAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQL 173
P +++K +LQ A R I RKIL +G + G V ++P+ T +
Sbjct: 538 PADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARV-FRSSPQFGVTLV 596
Query: 174 TRDLLR 179
T +LL+
Sbjct: 597 TYELLQ 602
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 213 bits (541), Expect = 2e-55
Identities = 127/299 (42%), Positives = 164/299 (54%), Gaps = 36/299 (12%)
Query: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQN-----GQRVYTSMSDCLIKTVRSEGYFGMYRGA 69
G +AG +G T V+PIDL KTR+QNQ++ G+ +Y + DC K +R EG+FG+YRG
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 394
Query: 70 AVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKI 129
L V PEKAIKL NDF R + + L E+LAG AG QVI T P+E++KI
Sbjct: 395 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKI 454
Query: 130 QLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKG 189
+LQ AG I PR +A + RDL G G+YKG
Sbjct: 455 RLQVAGEIT-------------------------TGPRVSALSVVRDL----GFFGIYKG 485
Query: 190 LGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVV 249
A LRD+PFS +YFP +A++ + SP + LAG +AG AA V P DV+
Sbjct: 486 AKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSL-LLAGAIAGMPAASLVTPADVI 544
Query: 250 KTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFL 308
KTRLQ R + TYSG++DC RKILR EGP A KGA R +P FG+ + Y L
Sbjct: 545 KTRLQVAAR-AGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYEL 602
Score = 58.2 bits (139), Expect = 1e-08
Identities = 51/197 (25%), Positives = 79/197 (40%), Gaps = 28/197 (14%)
Query: 3 DKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGY 62
D + L A+++ GG AG V P+++ K RL Q + T + VR G+
Sbjct: 423 DGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRL---QVAGEITTGPRVSALSVVRDLGF 479
Query: 63 FGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTT 122
FG+Y+GA P AI + + + +++ +LAG AG + T
Sbjct: 480 FGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVT 539
Query: 123 PMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRG 182
P +++K +LQ A R GQ + G R +LR G
Sbjct: 540 PADVIKTRLQVAAR----------AGQTTYSG---------------VIDCFRKILREEG 574
Query: 183 IAGLYKGLGATLLRDVP 199
L+KG GA + R P
Sbjct: 575 PKALWKGAGARVFRSSP 591
Score = 52.4 bits (124), Expect = 5e-07
Identities = 41/130 (31%), Positives = 58/130 (44%), Gaps = 16/130 (12%)
Query: 183 IAGLYKGLGATLLRDV-----------PFSVVYFPLFANLNQLGRPASEEKSPFYVSFLA 231
+A LY+ G L D+ PF++ RP + + F
Sbjct: 275 LADLYEPRGRMTLADIERIAPLEEGTLPFNLAEAQRQKASGDSARPVLLQVAESAYRFGL 334
Query: 232 GCVAGSAAAVAVNPCDVVKTRLQSLQRG----VNEDTYSGILDCARKILRHEGPSAFLKG 287
G VAG+ A AV P D+VKTR+Q+ QR V E Y DC +K+LR+EG +G
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQN-QRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRG 393
Query: 288 AYCRALVIAP 297
+ L +AP
Sbjct: 394 LLPQLLGVAP 403
Score = 52.0 bits (123), Expect = 7e-07
Identities = 29/83 (34%), Positives = 46/83 (55%), Gaps = 1/83 (1%)
Query: 3 DKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQ-NQQNGQRVYTSMSDCLIKTVRSEG 61
D Q+S + L+ G IAG+ + V P D+ KTRLQ + GQ Y+ + DC K +R EG
Sbjct: 515 DGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEG 574
Query: 62 YFGMYRGAAVNLTLVTPEKAIKL 84
+++GA + +P+ + L
Sbjct: 575 PKALWKGAGARVFRSSPQFGVTL 597
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 213 bits (541), Expect = 2e-55
Identities = 127/299 (42%), Positives = 164/299 (54%), Gaps = 36/299 (12%)
Query: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQN-----GQRVYTSMSDCLIKTVRSEGYFGMYRGA 69
G +AG +G T V+PIDL KTR+QNQ++ G+ +Y + DC K +R EG+FG+YRG
Sbjct: 336 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 395
Query: 70 AVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKI 129
L V PEKAIKL NDF R + + L E+LAG AG QVI T P+E++KI
Sbjct: 396 LPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKI 455
Query: 130 QLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKG 189
+LQ AG I PR +A + RDL G G+YKG
Sbjct: 456 RLQVAGEIT-------------------------TGPRVSALSVVRDL----GFFGIYKG 486
Query: 190 LGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVV 249
A LRD+PFS +YFP +A++ + SP + LAG +AG AA V P DV+
Sbjct: 487 AKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSL-LLAGAIAGMPAASLVTPADVI 545
Query: 250 KTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFL 308
KTRLQ R + TYSG++DC RKILR EGP A KGA R +P FG+ + Y L
Sbjct: 546 KTRLQVAAR-AGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYEL 603
Score = 58.2 bits (139), Expect = 1e-08
Identities = 51/197 (25%), Positives = 79/197 (40%), Gaps = 28/197 (14%)
Query: 3 DKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGY 62
D + L A+++ GG AG V P+++ K RL Q + T + VR G+
Sbjct: 424 DGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRL---QVAGEITTGPRVSALSVVRDLGF 480
Query: 63 FGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTT 122
FG+Y+GA P AI + + + +++ +LAG AG + T
Sbjct: 481 FGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVT 540
Query: 123 PMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRG 182
P +++K +LQ A R GQ + G R +LR G
Sbjct: 541 PADVIKTRLQVAAR----------AGQTTYSG---------------VIDCFRKILREEG 575
Query: 183 IAGLYKGLGATLLRDVP 199
L+KG GA + R P
Sbjct: 576 PKALWKGAGARVFRSSP 592
Score = 52.0 bits (123), Expect = 7e-07
Identities = 29/83 (34%), Positives = 46/83 (55%), Gaps = 1/83 (1%)
Query: 3 DKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQ-NQQNGQRVYTSMSDCLIKTVRSEG 61
D Q+S + L+ G IAG+ + V P D+ KTRLQ + GQ Y+ + DC K +R EG
Sbjct: 516 DGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEG 575
Query: 62 YFGMYRGAAVNLTLVTPEKAIKL 84
+++GA + +P+ + L
Sbjct: 576 PKALWKGAGARVFRSSPQFGVTL 598
Score = 50.8 bits (120), Expect = 2e-06
Identities = 33/86 (38%), Positives = 45/86 (52%), Gaps = 5/86 (5%)
Query: 216 RPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRG----VNEDTYSGILDC 271
RP + + F G VAG+ A AV P D+VKTR+Q+ QR V E Y DC
Sbjct: 320 RPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQN-QRSTGSFVGELMYKNSFDC 378
Query: 272 ARKILRHEGPSAFLKGAYCRALVIAP 297
+K+LR+EG +G + L +AP
Sbjct: 379 FKKVLRYEGFFGLYRGLLPQLLGVAP 404
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 118 bits (295), Expect = 8e-27
Identities = 92/316 (29%), Positives = 138/316 (43%), Gaps = 25/316 (7%)
Query: 13 INGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVN 72
+ G I G+ GV +P+D K R+Q + YT + C+ T E +G YRG ++
Sbjct: 4 VAGAIGGVCGVAVGYPLDTVKVRIQTEPK----YTGIWHCVRDTYHRERVWGFYRGLSLP 59
Query: 73 LTLVTPEKAIKLAANDFFRHQLS--------KDGQKLTLLKEMLAGCGAGTCQVIVTTPM 124
+ V+ ++ +RH L+ K T L+GC +G +V +T+P
Sbjct: 60 VCTVSLVSSVSFGT---YRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPT 116
Query: 125 EMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPT---ATQLTRDLLRSR 181
E+ K++LQ + Q++ L+A G L+ PA P P + R
Sbjct: 117 EVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVP---PACPEPKYRGPLHCLATVAREE 173
Query: 182 GIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAV 241
G+ GLYKG A +LRD YF +A L + PA + +AG AG A
Sbjct: 174 GLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWA 233
Query: 242 AVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGI 301
P DV+K+RLQ+ G + Y G+L C +R EGP KG P+ +
Sbjct: 234 VATPMDVIKSRLQA--DGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMV 291
Query: 302 AQVVY--FLGIAESLL 315
V Y L +A LL
Sbjct: 292 VFVAYEAVLRLARGLL 307
Score = 52.4 bits (124), Expect = 5e-07
Identities = 25/79 (31%), Positives = 41/79 (51%)
Query: 8 LPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYR 67
+P L+ GG AG++ P+D+ K+RLQ GQR Y + C++ +VR EG +++
Sbjct: 217 VPGVLVAGGCAGVLAWAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFK 276
Query: 68 GAAVNLTLVTPEKAIKLAA 86
G +N P + A
Sbjct: 277 GLVLNCCRAFPVNMVVFVA 295
Score = 34.3 bits (77), Expect = 0.15
Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 6/61 (9%)
Query: 227 VSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLK 286
+ F+AG + G P D VK R+Q+ E Y+GI C R E F +
Sbjct: 1 MDFVAGAIGGVCGVAVGYPLDTVKVRIQT------EPKYTGIWHCVRDTYHRERVWGFYR 54
Query: 287 G 287
G
Sbjct: 55 G 55
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 114 bits (284), Expect = 2e-25
Identities = 85/310 (27%), Positives = 145/310 (46%), Gaps = 41/310 (13%)
Query: 5 QISLPAK-LINGGIAGLIGVTCVFPIDLAKTRLQ-NQQNGQRVYTSMSDCLIKTVRSEGY 62
+++ P K ++ GG+AG I + FP + KT+LQ ++++ Y + DC+ +TVRS G
Sbjct: 21 KLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGV 80
Query: 63 FGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQ-VIVT 121
G+YRG + L P+ A++ +F + + +L + +L G GAG + V+V
Sbjct: 81 LGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVV 140
Query: 122 TPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQL---TRDLL 178
PME +K++ + +P P R+++
Sbjct: 141 CPMETIKVKF----------------------------IHDQTSPNPKYRGFFHGVREIV 172
Query: 179 RSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEK--SPFYVSFLAGCVAG 236
R +G+ G Y+GL AT+L+ + F + +L R + K +P ++ + G +AG
Sbjct: 173 REQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPL-ITGVFGAIAG 231
Query: 237 SAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIA 296
+A+ P DV+KTR+Q G+ Y DC +IL+ EG AF KG R +
Sbjct: 232 AASVFGNTPLDVIKTRMQ----GLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVC 287
Query: 297 PLFGIAQVVY 306
I V+Y
Sbjct: 288 LDVAIVFVIY 297
Score = 36.2 bits (82), Expect = 0.040
Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 5/80 (6%)
Query: 12 LINGGIAGLIGVTCVF---PIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
LI G + G VF P+D+ KTR+Q + Y + DC ++ ++ EG Y+G
Sbjct: 221 LITGVFGAIAGAASVFGNTPLDVIKTRMQGLE--AHKYRNTWDCGLQILKKEGLKAFYKG 278
Query: 69 AAVNLTLVTPEKAIKLAAND 88
L V + AI D
Sbjct: 279 TVPRLGRVCLDVAIVFVIYD 298
Score = 35.4 bits (80), Expect = 0.069
Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 8/96 (8%)
Query: 228 SFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
+ LAG +AG P + VKT+LQ +R + Y GI DC R+ +R G +G
Sbjct: 28 AILAGGLAGGIEICITFPTEYVKTQLQLDERS-HPPRYRGIGDCVRQTVRSHGVLGLYRG 86
Query: 288 AYCRALVIAPLFG-IAQVVYFLGIAESLLGLLQDPQ 322
+ + L+G I + G+ E L ++D Q
Sbjct: 87 ------LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQ 116
>gi|13775208 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 31 [Homo
sapiens]
Length = 315
Score = 109 bits (273), Expect = 3e-24
Identities = 82/293 (27%), Positives = 132/293 (45%), Gaps = 38/293 (12%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-----YTSMSDCLIKTVRSEGYFGMY 66
L+ GG+A + T V PI+ K LQ Q + +++ Y M DCL++ R +G+F +
Sbjct: 24 LLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFSFW 83
Query: 67 RGAAVNLTLVTPEKAIKLAAND----FFRHQLSKDGQKLT-LLKEMLAGCGAGTCQVIVT 121
RG N+ P +A+ A D F ++K+ Q L + +G AG + V
Sbjct: 84 RGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLCVV 143
Query: 122 TPMEMLKIQLQ-DAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRS 180
P++ + +L D G+ +R Q G + +S
Sbjct: 144 YPLDFARTRLGVDIGKGPEER-------QFKGLGDC-----------------IMKIAKS 179
Query: 181 RGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAA 240
GIAGLY+G G ++ + + YF + + G +K+PF VSF V + +
Sbjct: 180 DGIAGLYQGFGVSVQGIIVYRASYFGAYDTVK--GLLPKPKKTPFLVSFFIAQVVTTCSG 237
Query: 241 VAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRAL 293
+ P D V+ R+ +Q G + Y G LDC KI +HEG S+F +GA+ L
Sbjct: 238 ILSYPFDTVRRRMM-MQSGEAKRQYKGTLDCFVKIYQHEGISSFFRGAFSNVL 289
Score = 55.1 bits (131), Expect = 8e-08
Identities = 34/122 (27%), Positives = 60/122 (49%), Gaps = 4/122 (3%)
Query: 10 AKLINGGIAGLIGVTCVFPIDLAKTRLQ---NQQNGQRVYTSMSDCLIKTVRSEGYFGMY 66
A L +GG AG + V+P+D A+TRL + +R + + DC++K +S+G G+Y
Sbjct: 127 ANLASGGAAGATSLCVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSDGIAGLY 186
Query: 67 RGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEM 126
+G V++ + +A A D + L K +K L TC I++ P +
Sbjct: 187 QGFGVSVQGIIVYRASYFGAYDTVKGLLPKP-KKTPFLVSFFIAQVVTTCSGILSYPFDT 245
Query: 127 LK 128
++
Sbjct: 246 VR 247
Score = 53.1 bits (126), Expect = 3e-07
Identities = 56/229 (24%), Positives = 95/229 (41%), Gaps = 43/229 (18%)
Query: 105 KEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPA 164
K++LAG A P+E +K+ LQ + A+ Q+S + + V+
Sbjct: 22 KDLLAGGVAAAVSKTAVAPIERVKLLLQ----------VQASSKQISPEARYKGMVDC-- 69
Query: 165 APRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSP 224
L R + R +G ++G A ++R P + F QL ++
Sbjct: 70 --------LVR-IPREQGFFSFWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQ 120
Query: 225 FYVSFLAGCVAGSAAAVA----VNPCDVVKTRL-QSLQRGVNEDTYSGILDCARKILRHE 279
F+ FLA +G AA V P D +TRL + +G E + G+ DC KI + +
Sbjct: 121 FWRWFLANLASGGAAGATSLCVVYPLDFARTRLGVDIGKGPEERQFKGLGDCIMKIAKSD 180
Query: 280 GPSAFLKGAYCRALVIAPLFGIAQ---VVY---FLGIAESLLGLLQDPQ 322
G + +G FG++ +VY + G +++ GLL P+
Sbjct: 181 GIAGLYQG-----------FGVSVQGIIVYRASYFGAYDTVKGLLPKPK 218
Score = 37.0 bits (84), Expect = 0.024
Identities = 25/70 (35%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 221 EKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQ---SLQRGVNEDTYSGILDCARKILR 277
+ S F LAG VA + + AV P + VK LQ S ++ E Y G++DC +I R
Sbjct: 16 DASSFGKDLLAGGVAAAVSKTAVAPIERVKLLLQVQASSKQISPEARYKGMVDCLVRIPR 75
Query: 278 HEGPSAFLKG 287
+G +F +G
Sbjct: 76 EQGFFSFWRG 85
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 105 bits (263), Expect = 4e-23
Identities = 85/306 (27%), Positives = 127/306 (41%), Gaps = 40/306 (13%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG-- 68
+ + G I+G +G+ P D K RLQ Q Y + DC++K R E G ++G
Sbjct: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQTT----YRGIVDCMVKIYRHESLLGFFKGMS 60
Query: 69 ------AAVNLTL--VTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIV 120
A VN L V + L A HQ + Q + + LAGC G Q
Sbjct: 61 FPIASIAVVNSVLFGVYSNTLLVLTATS---HQ-ERRAQPPSYMHIFLAGCTGGFLQAYC 116
Query: 121 TTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRS 180
P +++K++LQ+ AQ G P + P + R
Sbjct: 117 LAPFDLIKVRLQNQTEPRAQ------------PGSPPPRYQGPV-------HCAASIFRE 157
Query: 181 RGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAA 240
G GL++G A LRD P +YF + L + P + S V +AG AG A+
Sbjct: 158 EGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATV-LVAGGFAGIASW 216
Query: 241 VAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFG 300
VA P D++K+R+Q G+ Y G+LDC +R EG F +G + P+
Sbjct: 217 VAATPLDMIKSRMQ--MDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNA 274
Query: 301 IAQVVY 306
+ + Y
Sbjct: 275 VTFLSY 280
Score = 55.1 bits (131), Expect = 8e-08
Identities = 24/78 (30%), Positives = 41/78 (52%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAV 71
L+ GG AG+ P+D+ K+R+Q +RVY M DC++ ++R EG +RG +
Sbjct: 205 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 264
Query: 72 NLTLVTPEKAIKLAANDF 89
N P A+ + ++
Sbjct: 265 NSARAFPVNAVTFLSYEY 282
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 105 bits (261), Expect = 7e-23
Identities = 82/300 (27%), Positives = 132/300 (44%), Gaps = 31/300 (10%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQ--NGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
+++ GG AGL+ + + P+D+ KTR Q Q+ Y S+ D + EG FG Y+G
Sbjct: 16 QIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKG 75
Query: 69 AAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
+ TP++A+K + ++ L L +AG G+G + IV P E++K
Sbjct: 76 ILPPILAETPKRAVKFFTFEQYKKLLGYVSLS-PALTFAIAGLGSGLTEAIVVNPFEVVK 134
Query: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRG--IAGL 186
+ LQ A R A Q P+ R +++ G + GL
Sbjct: 135 VGLQ------ANRNTFAEQ--------------------PSTVGYARQIIKKEGWGLQGL 168
Query: 187 YKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPC 246
KGL ATL R F++VYF + N+ + + F+ F G ++G+ A+V P
Sbjct: 169 NKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPF 228
Query: 247 DVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVY 306
DV K+R+Q Q E Y + + EG A KG + + + P + +VY
Sbjct: 229 DVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVY 288
Score = 34.7 bits (78), Expect = 0.12
Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 6/80 (7%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQNQQN--GQRVYTSMSDCLIKTVRSEGYFGMYRGA 69
L++G IA +I + P D+AK+R+Q Q G+ Y + + + EG +Y+G
Sbjct: 215 LLSGTIASVINI----PFDVAKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGL 270
Query: 70 AVNLTLVTPEKAIKLAANDF 89
+ + P A+ L ++
Sbjct: 271 LPKIMRLGPGGAVMLLVYEY 290
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 93.2 bits (230), Expect = 3e-19
Identities = 95/303 (31%), Positives = 133/303 (43%), Gaps = 51/303 (16%)
Query: 1 MAD--KQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQN---GQR-VYTSMSDCLI 54
MAD K IS L+ GG G+ V P+D K RLQ Q GQ +Y+ DC
Sbjct: 1 MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR 60
Query: 55 KTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQK------LTLLKEML 108
KT+ EG G+YRG A + VTP A+ FF L K Q+ L+ +
Sbjct: 61 KTLFREGITGLYRGMAAPIIGVTPMFAVC-----FFGFGLGKKLQQKHPEDVLSYPQLFA 115
Query: 109 AGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRP 168
AG +G + TP E +K LQ I A+ G+ G
Sbjct: 116 AGMLSGVFTTGIMTPGERIKCLLQ----------IQASSGESKYTG-------------- 151
Query: 169 TATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQL----GRPASEEKSP 224
+ L + GI G+YKG TL+RDVP S +YF + L + G+ SE +P
Sbjct: 152 -TLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAP 210
Query: 225 FYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAF 284
+ +AG +AG P DV+K+R Q+ G +G D R+++R EG ++
Sbjct: 211 RIL--VAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYP---NGFRDVLRELIRDEGVTSL 265
Query: 285 LKG 287
KG
Sbjct: 266 YKG 268
Score = 65.5 bits (158), Expect = 6e-11
Identities = 55/204 (26%), Positives = 83/204 (40%), Gaps = 25/204 (12%)
Query: 104 LKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAP 163
LK +LAG G C V V P++ +K++LQ QP
Sbjct: 11 LKNLLAGGFGGVCLVFVGHPLDTVKVRLQ-----------------------TQPPSLPG 47
Query: 164 AAPRPTAT-QLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEK 222
P + T R L GI GLY+G+ A ++ P V F F +L + E+
Sbjct: 48 QPPMYSGTFDCFRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDV 107
Query: 223 SPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPS 282
+ F AG ++G + P + +K LQ +Q E Y+G LDCA+K+ + G
Sbjct: 108 LSYPQLFAAGMLSGVFTTGIMTPGERIKCLLQ-IQASSGESKYTGTLDCAKKLYQEFGIR 166
Query: 283 AFLKGAYCRALVIAPLFGIAQVVY 306
KG + P G+ + Y
Sbjct: 167 GIYKGTVLTLMRDVPASGMYFMTY 190
Score = 56.2 bits (134), Expect = 4e-08
Identities = 48/204 (23%), Positives = 84/204 (41%), Gaps = 31/204 (15%)
Query: 6 ISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQ-QNGQRVYTSMSDCLIKTVRSEGYFG 64
+S P G ++G+ + P + K LQ Q +G+ YT DC K + G G
Sbjct: 108 LSYPQLFAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRG 167
Query: 65 MYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKE---MLAGCGAGTCQVIVT 121
+Y+G + L P + ++ ++ + +G++++ L ++AG AG V
Sbjct: 168 IYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVA 227
Query: 122 TPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSR 181
P ++LK + Q A P + P R + R+L+R
Sbjct: 228 IPPDVLKSRFQTA-----------------------PPGKYPNGFR----DVLRELIRDE 260
Query: 182 GIAGLYKGLGATLLRDVPFSVVYF 205
G+ LYKG A ++R P + F
Sbjct: 261 GVTSLYKGFNAVMIRAFPANAACF 284
Score = 42.7 bits (99), Expect = 4e-04
Identities = 26/84 (30%), Positives = 37/84 (44%), Gaps = 2/84 (2%)
Query: 228 SFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGV--NEDTYSGILDCARKILRHEGPSAFL 285
+ LAG G +P D VK RLQ+ + YSG DC RK L EG +
Sbjct: 13 NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
Query: 286 KGAYCRALVIAPLFGIAQVVYFLG 309
+G + + P+F + + LG
Sbjct: 73 RGMAAPIIGVTPMFAVCFFGFGLG 96
>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
Length = 298
Score = 92.0 bits (227), Expect = 6e-19
Identities = 75/306 (24%), Positives = 128/306 (41%), Gaps = 40/306 (13%)
Query: 1 MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-----YTSMSDCLIK 55
M D +S + GG+A I T V PI+ K LQ Q +++ Y + DC+++
Sbjct: 1 MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVR 60
Query: 56 TVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLT-----LLKEMLAG 110
+ +G +RG N+ P +A+ A D ++ K T + +G
Sbjct: 61 IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASG 120
Query: 111 CGAGTCQVIVTTPMEMLKIQLQ-DAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPT 169
AG + P++ + +L D G+ A+R+ R
Sbjct: 121 GAAGATSLCFVYPLDFARTRLAADVGKAGAEREF-----------------------RGL 157
Query: 170 ATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSF 229
L + + +S GI GLY+G ++ + + YF ++ G + + +S+
Sbjct: 158 GDCLVK-IYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAK--GMLPDPKNTHIVISW 214
Query: 230 LAGCVAGSAAAVAVNPCDVVKTRL--QSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
+ + A + P D V+ R+ QS ++G + Y+G LDC RKI R EG AF KG
Sbjct: 215 MIAQTVTAVAGLTSYPFDTVRRRMMMQSGRKGT-DIMYTGTLDCWRKIARDEGGKAFFKG 273
Query: 288 AYCRAL 293
A+ L
Sbjct: 274 AWSNVL 279
>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
Length = 298
Score = 90.5 bits (223), Expect = 2e-18
Identities = 76/306 (24%), Positives = 128/306 (41%), Gaps = 40/306 (13%)
Query: 1 MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-----YTSMSDCLIK 55
M ++ IS + GGIA I T V PI+ K LQ Q +++ Y + DC+++
Sbjct: 1 MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVR 60
Query: 56 TVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLT-----LLKEMLAG 110
+ +G +RG N+ P +A+ A D ++ K T + +G
Sbjct: 61 IPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASG 120
Query: 111 CGAGTCQVIVTTPMEMLKIQLQ-DAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPT 169
AG + P++ + +L D G+ +R+ R
Sbjct: 121 GAAGATSLCFVYPLDFARTRLAADVGKSGTEREF-----------------------RGL 157
Query: 170 ATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSF 229
L + + +S GI GLY+G ++ + + YF ++ G + + VS+
Sbjct: 158 GDCLVK-ITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAK--GMLPDPKNTHIVVSW 214
Query: 230 LAGCVAGSAAAVAVNPCDVVKTRL--QSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
+ + A V P D V+ R+ QS ++G + Y+G +DC RKI R EG AF KG
Sbjct: 215 MIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGA-DIMYTGTVDCWRKIFRDEGGKAFFKG 273
Query: 288 AYCRAL 293
A+ L
Sbjct: 274 AWSNVL 279
Score = 49.7 bits (117), Expect = 4e-06
Identities = 54/229 (23%), Positives = 93/229 (40%), Gaps = 31/229 (13%)
Query: 99 QKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQP 158
Q ++ K+ LAG A P+E +K+ LQ + K +AA Q +G
Sbjct: 4 QAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQ----VQHASKQIAADKQY--KGIVDC 57
Query: 159 SVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPA 218
V P + +G+ ++G A ++R P + F Q+
Sbjct: 58 IVRIP---------------KEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGG 102
Query: 219 SEEKSPFYVSFLAGCVAGSAAAVA----VNPCDVVKTRLQS-LQRGVNEDTYSGILDCAR 273
++ + F+ F +G AA V P D +TRL + + + E + G+ DC
Sbjct: 103 VDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLV 162
Query: 274 KILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQDPQ 322
KI + +G ++G Y V I + YF G+ ++ G+L DP+
Sbjct: 163 KITKSDG----IRGLYQGFSVSVQGIIIYRAAYF-GVYDTAKGMLPDPK 206
>gi|115430257 solute carrier family 25, member 26 [Homo sapiens]
Length = 274
Score = 90.5 bits (223), Expect = 2e-18
Identities = 73/288 (25%), Positives = 118/288 (40%), Gaps = 47/288 (16%)
Query: 10 AKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGA 69
A L+ GG+AG+ +FP+D KTRLQ+ Q + + G+ G+Y G
Sbjct: 8 AALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNK--------------AGGFHGIYAGV 53
Query: 70 AVNLTLVTPEKAIKLAANDFFRHQLSKDGQK-LTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
P A ++ + L D LT +K MLA ++ P E++K
Sbjct: 54 PSAAIGSFPNAAAFFITYEYVKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVK 113
Query: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYK 188
+ Q ++A + Q+ ++L GI GLY+
Sbjct: 114 QRAQ----VSASTRTF---------------------------QIFSNILYEEGIQGLYR 142
Query: 189 GLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDV 248
G +T+LR++PFS+V FPL+ +L L + + S + G AG AA P DV
Sbjct: 143 GYKSTVLREIPFSLVQFPLWESLKALWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDV 202
Query: 249 VKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIA 296
KTR+ + G + +L + R +G + G + R I+
Sbjct: 203 AKTRIMLAKAG-SSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAIS 249
Score = 31.2 bits (69), Expect = 1.3
Identities = 15/37 (40%), Positives = 23/37 (62%)
Query: 221 EKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQ 257
++ F + +AG VAG + + + P D +KTRLQS Q
Sbjct: 2 DRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQ 38
Score = 30.0 bits (66), Expect = 2.9
Identities = 25/91 (27%), Positives = 41/91 (45%), Gaps = 9/91 (9%)
Query: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTV-----RSEGYFGMYRGA 69
G AG P+D+AKTR+ + G +S +D + +V RS+G G++ G
Sbjct: 186 GAFAGGFAAAVTTPLDVAKTRIMLAKAG----SSTADGNVLSVLHGVWRSQGLAGLFAGV 241
Query: 70 AVNLTLVTPEKAIKLAANDFFRHQLSKDGQK 100
+ ++ I L A D L + G+K
Sbjct: 242 FPRMAAISLGGFIFLGAYDRTHSLLLEVGRK 272
>gi|45237193 solute carrier family 25, member 44 isoform 1 [Homo
sapiens]
Length = 314
Score = 89.0 bits (219), Expect = 5e-18
Identities = 74/274 (27%), Positives = 129/274 (47%), Gaps = 23/274 (8%)
Query: 26 VFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVN-LTLVTPEKAIKL 84
V+P L +TRLQ Q+ G+ +Y D IK +R++G G+YRG VN TL++ + +
Sbjct: 35 VYPFTLIRTRLQVQK-GKSLYHGTFDAFIKILRADGITGLYRGFLVNTFTLISGQCYVTT 93
Query: 85 AANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKIL 144
+ D + +K ++AG A +T P++++ L QRK
Sbjct: 94 YE---LTRKFVADYSQSNTVKSLVAGGSASLVAQSITVPIDVVSQHLM------MQRK-G 143
Query: 145 AAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVY 204
G+ +G P + A T + R +L++ G+ G Y+G A+LL +P S V+
Sbjct: 144 EKMGRFQVRG--NPEGQGVVAFGQT-KDIIRQILQADGLRGFYRGYVASLLTYIPNSAVW 200
Query: 205 FPLF-ANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNED 263
+P + QL +E ++G +A + A++ NP DV++TR+Q +
Sbjct: 201 WPFYHFYAEQLSYLCPKECPHIVFQAVSGPLAAATASILTNPMDVIRTRVQ-------VE 253
Query: 264 TYSGILDCARKILRHEGPSAFLKGAYCRALVIAP 297
+ I+ R+++ EGP +KG R + P
Sbjct: 254 GKNSIILTFRQLMAEEGPWGLMKGLSARIISATP 287
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 89.0 bits (219), Expect = 5e-18
Identities = 78/276 (28%), Positives = 111/276 (40%), Gaps = 36/276 (13%)
Query: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAVNLT 74
G G+ GV P D K RLQ Q + Y C ++ E G+Y+G L
Sbjct: 8 GCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLGSPLM 67
Query: 75 LVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK--IQLQ 132
+T A+ L D L + LAG AG Q ++ PME+ K +QLQ
Sbjct: 68 GLTFINALVFGVQGNTLRALGHDSP----LNQFLAGAAAGAIQCVICCPMELAKTRLQLQ 123
Query: 133 DAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGA 192
DAG PA + + G+ G+ +G+ +
Sbjct: 124 DAG---------------------------PARTYKGSLDCLAQIYGHEGLRGVNRGMVS 156
Query: 193 TLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTR 252
TLLR+ P VYF + L + ++ LAG +G + ++ P DVVK+R
Sbjct: 157 TLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSR 216
Query: 253 LQS-LQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
LQ+ RG Y GILDC + R EG F +G
Sbjct: 217 LQADGLRGA--PRYRGILDCVHQSYRAEGWRVFTRG 250
Score = 71.2 bits (173), Expect = 1e-12
Identities = 58/203 (28%), Positives = 86/203 (42%), Gaps = 36/203 (17%)
Query: 106 EMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAA 165
+ LAGC G V+V P + +K++LQ V++
Sbjct: 4 DFLAGCAGGVAGVLVGHPFDTVKVRLQ---------------------------VQSVEK 36
Query: 166 PRPTAT-QLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFAN-LNQLGRPASEEKS 223
P+ T + +++ + GLYKGLG+ L+ + + F + N L LG + +
Sbjct: 37 PQYRGTLHCFKSIIKQESVLGLYKGLGSPLMGLTFINALVFGVQGNTLRALGHDSPLNQ- 95
Query: 224 PFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSA 283
FLAG AG+ V P ++ KTRLQ LQ TY G LDC +I HEG
Sbjct: 96 -----FLAGAAAGAIQCVICCPMELAKTRLQ-LQDAGPARTYKGSLDCLAQIYGHEGLRG 149
Query: 284 FLKGAYCRALVIAPLFGIAQVVY 306
+G L P FG+ + Y
Sbjct: 150 VNRGMVSTLLRETPSFGVYFLTY 172
Score = 60.8 bits (146), Expect = 2e-09
Identities = 44/133 (33%), Positives = 62/133 (46%), Gaps = 2/133 (1%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNG-QRVYTSMSDCLIKTVRSEGYFGMYRGA 69
+ + G AG I P++LAKTRLQ Q G R Y DCL + EG G+ RG
Sbjct: 95 QFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGM 154
Query: 70 AVNLTLVTPEKAIKLAANDFFRHQLS-KDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
L TP + D L + G +L + K +LAG +G + T P++++K
Sbjct: 155 VSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVK 214
Query: 129 IQLQDAGRIAAQR 141
+LQ G A R
Sbjct: 215 SRLQADGLRGAPR 227
Score = 45.1 bits (105), Expect = 9e-05
Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Query: 5 QISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQ-NQQNGQRVYTSMSDCLIKTVRSEGYF 63
++ +P L+ GG +G++ +P+D+ K+RLQ + G Y + DC+ ++ R+EG+
Sbjct: 186 RLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWR 245
Query: 64 GMYRGAAVNLTLVTPEKAIKLA 85
RG A L P A A
Sbjct: 246 VFTRGLASTLLRAFPVNAATFA 267
Score = 43.9 bits (102), Expect = 2e-04
Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 2/61 (3%)
Query: 227 VSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLK 286
+ FLAGC G A + +P D VK RLQ + V + Y G L C + I++ E K
Sbjct: 3 LDFLAGCAGGVAGVLVGHPFDTVKVRLQ--VQSVEKPQYRGTLHCFKSIIKQESVLGLYK 60
Query: 287 G 287
G
Sbjct: 61 G 61
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 87.4 bits (215), Expect = 2e-17
Identities = 74/294 (25%), Positives = 114/294 (38%), Gaps = 33/294 (11%)
Query: 2 ADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-------YTSMSDCLI 54
+D ++ K + G A FP+D AK RLQ Q Q V Y + ++
Sbjct: 7 SDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTIL 66
Query: 55 KTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLS-KDGQKLTLLKEMLAGCGA 113
VR+EG Y G L +I++ D + + K +L +LAGC
Sbjct: 67 TMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTT 126
Query: 114 GTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQL 173
G V P +++K++ Q + + R G + A
Sbjct: 127 GAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAY-------------------- 166
Query: 174 TRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGC 233
R + R G+ GL+KG ++R+ + + L + F F++
Sbjct: 167 -RTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAF 225
Query: 234 VAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
AG A V +P DVVKTR + G Y LDC K++ EGP+AF KG
Sbjct: 226 GAGFCATVVASPVDVVKTRYMNSPPG----QYFSPLDCMIKMVAQEGPTAFYKG 275
Score = 69.3 bits (168), Expect = 4e-12
Identities = 61/212 (28%), Positives = 92/212 (43%), Gaps = 28/212 (13%)
Query: 110 GCGAGTCQV-IVTTPMEMLKIQLQDAGRIAAQR--KILAAQGQLSAQGGAQPSVEAPAAP 166
G G C +VT P++ K++LQ G A + +++ +G L
Sbjct: 19 GAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLG--------------- 63
Query: 167 RPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFY 226
T LT ++R+ G Y GL A L R + F+ + L+ ++ Q+ P + S
Sbjct: 64 ----TILT--MVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLT 117
Query: 227 VSFLAGCVAGSAAAVAVNPCDVVKTRLQS---LQRGVNEDTYSGILDCARKILRHEGPSA 283
LAGC G+ A P DVVK R Q+ L ++ YSG +D R I R EG
Sbjct: 118 TRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRG 177
Query: 284 FLKGAYCRALVIAPLFGIAQVVYFLGIAESLL 315
KG + A + A+VV + + E LL
Sbjct: 178 LWKGTLPNIMRNA-IVNCAEVVTYDILKEKLL 208
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 87.4 bits (215), Expect = 2e-17
Identities = 74/294 (25%), Positives = 114/294 (38%), Gaps = 33/294 (11%)
Query: 2 ADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-------YTSMSDCLI 54
+D ++ K + G A FP+D AK RLQ Q Q V Y + ++
Sbjct: 7 SDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTIL 66
Query: 55 KTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLS-KDGQKLTLLKEMLAGCGA 113
VR+EG Y G L +I++ D + + K +L +LAGC
Sbjct: 67 TMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTT 126
Query: 114 GTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQL 173
G V P +++K++ Q + + R G + A
Sbjct: 127 GAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAY-------------------- 166
Query: 174 TRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGC 233
R + R G+ GL+KG ++R+ + + L + F F++
Sbjct: 167 -RTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAF 225
Query: 234 VAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
AG A V +P DVVKTR + G Y LDC K++ EGP+AF KG
Sbjct: 226 GAGFCATVVASPVDVVKTRYMNSPPG----QYFSPLDCMIKMVAQEGPTAFYKG 275
Score = 69.3 bits (168), Expect = 4e-12
Identities = 61/212 (28%), Positives = 92/212 (43%), Gaps = 28/212 (13%)
Query: 110 GCGAGTCQV-IVTTPMEMLKIQLQDAGRIAAQR--KILAAQGQLSAQGGAQPSVEAPAAP 166
G G C +VT P++ K++LQ G A + +++ +G L
Sbjct: 19 GAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLG--------------- 63
Query: 167 RPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFY 226
T LT ++R+ G Y GL A L R + F+ + L+ ++ Q+ P + S
Sbjct: 64 ----TILT--MVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLT 117
Query: 227 VSFLAGCVAGSAAAVAVNPCDVVKTRLQS---LQRGVNEDTYSGILDCARKILRHEGPSA 283
LAGC G+ A P DVVK R Q+ L ++ YSG +D R I R EG
Sbjct: 118 TRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRG 177
Query: 284 FLKGAYCRALVIAPLFGIAQVVYFLGIAESLL 315
KG + A + A+VV + + E LL
Sbjct: 178 LWKGTLPNIMRNA-IVNCAEVVTYDILKEKLL 208
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 85.5 bits (210), Expect = 6e-17
Identities = 80/295 (27%), Positives = 122/295 (41%), Gaps = 41/295 (13%)
Query: 13 INGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV--------YTSMSDCLIKTVRSEGYFG 64
+ GG+A ++ FP+DL KTRLQ Q GQ + Y M L + + EG
Sbjct: 45 VYGGLASIVAEFGTFPVDLTKTRLQVQ--GQSIDARFKEIKYRGMFHALFRICKEEGVLA 102
Query: 65 MYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPM 124
+Y G A L IK+ + + + TLL M+ G +G + P
Sbjct: 103 LYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPT 162
Query: 125 EMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIA 184
++LKI++Q AQG L QG S D+ + G
Sbjct: 163 DVLKIRMQ-------------AQGSLF-QGSMIGSFI--------------DIYQQEGTR 194
Query: 185 GLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVN 244
GL++G+ T R V P++ + + F++ G A A+A N
Sbjct: 195 GLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASN 254
Query: 245 PCDVVKTRLQSLQRGV--NEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAP 297
P DVV+TR+ + QR + + D Y G +D K+ +HEG A KG + L + P
Sbjct: 255 PVDVVRTRMMN-QRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGP 308
Score = 47.0 bits (110), Expect = 2e-05
Identities = 30/130 (23%), Positives = 57/130 (43%), Gaps = 5/130 (3%)
Query: 177 LLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAG 236
+ + G+ LY G+ LLR + + ++ +L +L E+++ ++ + G V+G
Sbjct: 94 ICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDET-LLINMICGVVSG 152
Query: 237 SAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIA 296
++ NP DV+K R+Q+ +D I + EG +G A A
Sbjct: 153 VISSTIANPTDVLKIRMQAQGSLFQGSMIGSFID----IYQQEGTRGLWRGVVPTAQRAA 208
Query: 297 PLFGIAQVVY 306
+ G+ VY
Sbjct: 209 IVVGVELPVY 218
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/209 (21%), Positives = 83/209 (39%), Gaps = 26/209 (12%)
Query: 7 SLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMY 66
+L +I G ++G+I T P D+ K R+Q Q G SM I + EG G++
Sbjct: 140 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQ--GSLFQGSMIGSFIDIYQQEGTRGLW 197
Query: 67 RGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKL-TLLKEMLAGCGAGTCQVIVTTPME 125
RG ++L D + L G T+L ++ G + + P++
Sbjct: 198 RGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVD 257
Query: 126 MLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAG 185
+++ ++ + QR I+ G + G + + + G
Sbjct: 258 VVRTRMMN------QRAIV---GHVDLYKGTVDGI--------------LKMWKHEGFFA 294
Query: 186 LYKGLGATLLRDVPFSVVYFPLFANLNQL 214
LYKG LR P+++++F + L +L
Sbjct: 295 LYKGFWPNWLRLGPWNIIFFITYEQLKRL 323
Score = 32.0 bits (71), Expect = 0.76
Identities = 35/141 (24%), Positives = 58/141 (41%), Gaps = 9/141 (6%)
Query: 185 GLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPF-YVSFLAGCVAGSAAAVAV 243
G++ G+ LR V F+ + + +Q S E S + F+ G +A A
Sbjct: 2 GIFPGIILIFLR-VKFATA--AVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGT 58
Query: 244 NPCDVVKTRL----QSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLF 299
P D+ KTRL QS+ E Y G+ +I + EG A G AL+ +
Sbjct: 59 FPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSG-IAPALLRQASY 117
Query: 300 GIAQVVYFLGIAESLLGLLQD 320
G ++ + + + L+D
Sbjct: 118 GTIKIGIYQSLKRLFVERLED 138
>gi|13259543 solute carrier family 25, member 14 isoform UCP5S [Homo
sapiens]
Length = 322
Score = 85.5 bits (210), Expect = 6e-17
Identities = 80/295 (27%), Positives = 122/295 (41%), Gaps = 41/295 (13%)
Query: 13 INGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV--------YTSMSDCLIKTVRSEGYFG 64
+ GG+A ++ FP+DL KTRLQ Q GQ + Y M L + + EG
Sbjct: 42 VYGGLASIVAEFGTFPVDLTKTRLQVQ--GQSIDARFKEIKYRGMFHALFRICKEEGVLA 99
Query: 65 MYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPM 124
+Y G A L IK+ + + + TLL M+ G +G + P
Sbjct: 100 LYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPT 159
Query: 125 EMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIA 184
++LKI++Q AQG L QG S D+ + G
Sbjct: 160 DVLKIRMQ-------------AQGSLF-QGSMIGSFI--------------DIYQQEGTR 191
Query: 185 GLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVN 244
GL++G+ T R V P++ + + F++ G A A+A N
Sbjct: 192 GLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASN 251
Query: 245 PCDVVKTRLQSLQRGV--NEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAP 297
P DVV+TR+ + QR + + D Y G +D K+ +HEG A KG + L + P
Sbjct: 252 PVDVVRTRMMN-QRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGP 305
Score = 47.0 bits (110), Expect = 2e-05
Identities = 30/130 (23%), Positives = 57/130 (43%), Gaps = 5/130 (3%)
Query: 177 LLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAG 236
+ + G+ LY G+ LLR + + ++ +L +L E+++ ++ + G V+G
Sbjct: 91 ICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDET-LLINMICGVVSG 149
Query: 237 SAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIA 296
++ NP DV+K R+Q+ +D I + EG +G A A
Sbjct: 150 VISSTIANPTDVLKIRMQAQGSLFQGSMIGSFID----IYQQEGTRGLWRGVVPTAQRAA 205
Query: 297 PLFGIAQVVY 306
+ G+ VY
Sbjct: 206 IVVGVELPVY 215
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/209 (21%), Positives = 83/209 (39%), Gaps = 26/209 (12%)
Query: 7 SLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMY 66
+L +I G ++G+I T P D+ K R+Q Q G SM I + EG G++
Sbjct: 137 TLLINMICGVVSGVISSTIANPTDVLKIRMQAQ--GSLFQGSMIGSFIDIYQQEGTRGLW 194
Query: 67 RGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKL-TLLKEMLAGCGAGTCQVIVTTPME 125
RG ++L D + L G T+L ++ G + + P++
Sbjct: 195 RGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVD 254
Query: 126 MLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAG 185
+++ ++ + QR I+ G + G + + + G
Sbjct: 255 VVRTRMMN------QRAIV---GHVDLYKGTVDGI--------------LKMWKHEGFFA 291
Query: 186 LYKGLGATLLRDVPFSVVYFPLFANLNQL 214
LYKG LR P+++++F + L +L
Sbjct: 292 LYKGFWPNWLRLGPWNIIFFITYEQLKRL 320
Score = 35.0 bits (79), Expect = 0.090
Identities = 36/141 (25%), Positives = 57/141 (40%), Gaps = 12/141 (8%)
Query: 185 GLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPF-YVSFLAGCVAGSAAAVAV 243
G++ G+ LR V F A ++Q S E S + F+ G +A A
Sbjct: 2 GIFPGIILIFLR------VKFATAAVIHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGT 55
Query: 244 NPCDVVKTRL----QSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLF 299
P D+ KTRL QS+ E Y G+ +I + EG A G AL+ +
Sbjct: 56 FPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSG-IAPALLRQASY 114
Query: 300 GIAQVVYFLGIAESLLGLLQD 320
G ++ + + + L+D
Sbjct: 115 GTIKIGIYQSLKRLFVERLED 135
>gi|55749577 solute carrier family 25 (mitochondrial carrier;
adenine nucleotide translocator), member 4 [Homo
sapiens]
Length = 298
Score = 85.1 bits (209), Expect = 8e-17
Identities = 73/306 (23%), Positives = 129/306 (42%), Gaps = 40/306 (13%)
Query: 1 MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-----YTSMSDCLIK 55
M D S + GG+A + T V PI+ K LQ Q +++ Y + DC+++
Sbjct: 1 MGDHAWSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVR 60
Query: 56 TVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQL--SKDGQKLT---LLKEMLAG 110
+ +G+ +RG N+ P +A+ A D ++ D K + +G
Sbjct: 61 IPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASG 120
Query: 111 CGAGTCQVIVTTPMEMLKIQLQ-DAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPT 169
AG + P++ + +L D G+ AAQR+ G ++
Sbjct: 121 GAAGATSLCFVYPLDFARTRLAADVGKGAAQREF---------HGLGDCIIK-------- 163
Query: 170 ATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSF 229
+ +S G+ GLY+G ++ + + YF ++ G + +VS+
Sbjct: 164 -------IFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAK--GMLPDPKNVHIFVSW 214
Query: 230 LAGCVAGSAAAVAVNPCDVVKTRL--QSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
+ + A + P D V+ R+ QS ++G + Y+G +DC RKI + EG AF KG
Sbjct: 215 MIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGA-DIMYTGTVDCWRKIAKDEGAKAFFKG 273
Query: 288 AYCRAL 293
A+ L
Sbjct: 274 AWSNVL 279
>gi|116235466 solute carrier family 25, member 45 isoform b [Homo
sapiens]
Length = 246
Score = 82.8 bits (203), Expect = 4e-16
Identities = 71/264 (26%), Positives = 107/264 (40%), Gaps = 36/264 (13%)
Query: 53 LIKTVRSEGYFGMYRG--------AAVNLTL--VTPEKAIKLAANDFFRHQLSKDGQKLT 102
++K R E G ++G A VN L V + L A HQ + Q +
Sbjct: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATS---HQ-ERRAQPPS 56
Query: 103 LLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEA 162
+ LAGC G Q P +++K++LQ+ AQ G P +
Sbjct: 57 YMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQ------------PGSPPPRYQG 104
Query: 163 PAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEK 222
P + R G GL++G A LRD P +YF + L + P +
Sbjct: 105 PV-------HCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNP 157
Query: 223 SPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPS 282
S V +AG AG A+ VA P D++K+R+Q G+ Y G+LDC +R EG
Sbjct: 158 SSATV-LVAGGFAGIASWVAATPLDMIKSRMQ--MDGLRRRVYQGMLDCMVSSIRQEGLG 214
Query: 283 AFLKGAYCRALVIAPLFGIAQVVY 306
F +G + P+ + + Y
Sbjct: 215 VFFRGVTINSARAFPVNAVTFLSY 238
Score = 55.1 bits (131), Expect = 8e-08
Identities = 24/78 (30%), Positives = 41/78 (52%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAV 71
L+ GG AG+ P+D+ K+R+Q +RVY M DC++ ++R EG +RG +
Sbjct: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 222
Query: 72 NLTLVTPEKAIKLAANDF 89
N P A+ + ++
Sbjct: 223 NSARAFPVNAVTFLSYEY 240
Score = 54.7 bits (130), Expect = 1e-07
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 7/128 (5%)
Query: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-------YTSMSDCLIKTVRSEGYFGMYR 67
G G + C+ P DL K RLQNQ + Y C R EG G++R
Sbjct: 64 GCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFR 123
Query: 68 GAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEML 127
GA TP I + Q + +GQ + ++AG AG + TP++M+
Sbjct: 124 GAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMI 183
Query: 128 KIQLQDAG 135
K ++Q G
Sbjct: 184 KSRMQMDG 191
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 82.8 bits (203), Expect = 4e-16
Identities = 68/225 (30%), Positives = 101/225 (44%), Gaps = 35/225 (15%)
Query: 84 LAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKI 143
L D F K GQ +++LAG AG T P++ LKI +Q G
Sbjct: 178 LTIPDEFTEDEKKSGQ---WWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHG-------- 226
Query: 144 LAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVV 203
+ +++ GG R +++ GI L++G G +++ P + V
Sbjct: 227 -SKSDKMNIFGG------------------FRQMVKEGGIRSLWRGNGTNVIKIAPETAV 267
Query: 204 YFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNED 263
F + +L +K + F++G +AG+ A + P +V+KTRL + G
Sbjct: 268 KFWAYEQYKKL-LTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTG---- 322
Query: 264 TYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFL 308
YSGI DCA+KIL+HEG AF KG L I P GI VY L
Sbjct: 323 QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYEL 367
Score = 81.3 bits (199), Expect = 1e-15
Identities = 72/305 (23%), Positives = 130/305 (42%), Gaps = 45/305 (14%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLI------KTVRSEGYFG 64
+L+ GGIAG + T P+D K +Q V+ S SD + + V+ G
Sbjct: 197 QLLAGGIAGAVSRTSTAPLDRLKIMMQ-------VHGSKSDKMNIFGGFRQMVKEGGIRS 249
Query: 65 MYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPM 124
++RG N+ + PE A+K A + ++ L+++GQK+ + ++G AG PM
Sbjct: 250 LWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPM 309
Query: 125 EMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIA 184
E++K +L A G+ G + +L+ G+
Sbjct: 310 EVMKTRL--------------AVGKTGQYSGIY--------------DCAKKILKHEGLG 341
Query: 185 GLYKGLGATLLRDVPFSVVYFPLFANLNQ--LGRPASEEKSPFYVSFL-AGCVAGSAAAV 241
YKG LL +P++ + ++ L L A + +P + L G ++ + +
Sbjct: 342 AFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQL 401
Query: 242 AVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGI 301
A P +V+TR+Q+ Q + ++ R+I+ EG +G + + P GI
Sbjct: 402 ASYPLALVRTRMQA-QAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGI 460
Query: 302 AQVVY 306
+ VVY
Sbjct: 461 SYVVY 465
Score = 71.2 bits (173), Expect = 1e-12
Identities = 52/209 (24%), Positives = 95/209 (45%), Gaps = 35/209 (16%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
+ I+G +AG T ++P+++ KTRL + GQ Y+ + DC K ++ EG Y+G
Sbjct: 291 RFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQ--YSGIYDCAKKILKHEGLGAFYKGYV 348
Query: 71 VNLTLVTPEKAIKLAA----NDFFRHQLSKDGQKLTLLKEMLAGCGA--GTCQVIVTTPM 124
NL + P I LA ++ +KD ++ +L GCGA TC + + P+
Sbjct: 349 PNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVM--VLLGCGALSSTCGQLASYPL 406
Query: 125 EMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIA 184
+++ ++Q AQ L +P+ L R ++ GI
Sbjct: 407 ALVRTRMQ-------------AQAMLE------------GSPQLNMVGLFRRIISKEGIP 441
Query: 185 GLYKGLGATLLRDVPFSVVYFPLFANLNQ 213
GLY+G+ ++ +P + + ++ N+ Q
Sbjct: 442 GLYRGITPNFMKVLPAVGISYVVYENMKQ 470
Score = 30.8 bits (68), Expect = 1.7
Identities = 20/81 (24%), Positives = 33/81 (40%), Gaps = 1/81 (1%)
Query: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQNGQ-RVYTSMSDCLIKTVRSEGYFGMYRGAAVNL 73
G ++ G +P+ L +TR+Q Q + +M + + EG G+YRG N
Sbjct: 392 GALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNF 451
Query: 74 TLVTPEKAIKLAANDFFRHQL 94
V P I + + L
Sbjct: 452 MKVLPAVGISYVVYENMKQTL 472
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 82.8 bits (203), Expect = 4e-16
Identities = 68/225 (30%), Positives = 101/225 (44%), Gaps = 35/225 (15%)
Query: 84 LAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKI 143
L D F K GQ +++LAG AG T P++ LKI +Q G
Sbjct: 159 LTIPDEFTEDEKKSGQ---WWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHG-------- 207
Query: 144 LAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVV 203
+ +++ GG R +++ GI L++G G +++ P + V
Sbjct: 208 -SKSDKMNIFGG------------------FRQMVKEGGIRSLWRGNGTNVIKIAPETAV 248
Query: 204 YFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNED 263
F + +L +K + F++G +AG+ A + P +V+KTRL + G
Sbjct: 249 KFWAYEQYKKL-LTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTG---- 303
Query: 264 TYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQVVYFL 308
YSGI DCA+KIL+HEG AF KG L I P GI VY L
Sbjct: 304 QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYEL 348
Score = 81.3 bits (199), Expect = 1e-15
Identities = 72/305 (23%), Positives = 130/305 (42%), Gaps = 45/305 (14%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLI------KTVRSEGYFG 64
+L+ GGIAG + T P+D K +Q V+ S SD + + V+ G
Sbjct: 178 QLLAGGIAGAVSRTSTAPLDRLKIMMQ-------VHGSKSDKMNIFGGFRQMVKEGGIRS 230
Query: 65 MYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPM 124
++RG N+ + PE A+K A + ++ L+++GQK+ + ++G AG PM
Sbjct: 231 LWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPM 290
Query: 125 EMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIA 184
E++K +L A G+ G + +L+ G+
Sbjct: 291 EVMKTRL--------------AVGKTGQYSGIY--------------DCAKKILKHEGLG 322
Query: 185 GLYKGLGATLLRDVPFSVVYFPLFANLNQ--LGRPASEEKSPFYVSFL-AGCVAGSAAAV 241
YKG LL +P++ + ++ L L A + +P + L G ++ + +
Sbjct: 323 AFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQL 382
Query: 242 AVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGI 301
A P +V+TR+Q+ Q + ++ R+I+ EG +G + + P GI
Sbjct: 383 ASYPLALVRTRMQA-QAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGI 441
Query: 302 AQVVY 306
+ VVY
Sbjct: 442 SYVVY 446
Score = 71.2 bits (173), Expect = 1e-12
Identities = 52/209 (24%), Positives = 95/209 (45%), Gaps = 35/209 (16%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
+ I+G +AG T ++P+++ KTRL + GQ Y+ + DC K ++ EG Y+G
Sbjct: 272 RFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQ--YSGIYDCAKKILKHEGLGAFYKGYV 329
Query: 71 VNLTLVTPEKAIKLAA----NDFFRHQLSKDGQKLTLLKEMLAGCGA--GTCQVIVTTPM 124
NL + P I LA ++ +KD ++ +L GCGA TC + + P+
Sbjct: 330 PNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVM--VLLGCGALSSTCGQLASYPL 387
Query: 125 EMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIA 184
+++ ++Q AQ L +P+ L R ++ GI
Sbjct: 388 ALVRTRMQ-------------AQAMLE------------GSPQLNMVGLFRRIISKEGIP 422
Query: 185 GLYKGLGATLLRDVPFSVVYFPLFANLNQ 213
GLY+G+ ++ +P + + ++ N+ Q
Sbjct: 423 GLYRGITPNFMKVLPAVGISYVVYENMKQ 451
Score = 30.8 bits (68), Expect = 1.7
Identities = 20/81 (24%), Positives = 33/81 (40%), Gaps = 1/81 (1%)
Query: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQNGQ-RVYTSMSDCLIKTVRSEGYFGMYRGAAVNL 73
G ++ G +P+ L +TR+Q Q + +M + + EG G+YRG N
Sbjct: 373 GALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNF 432
Query: 74 TLVTPEKAIKLAANDFFRHQL 94
V P I + + L
Sbjct: 433 MKVLPAVGISYVVYENMKQTL 453
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 82.4 bits (202), Expect = 5e-16
Identities = 75/303 (24%), Positives = 125/303 (41%), Gaps = 43/303 (14%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQ---NQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
L+ GG AG + TC P+D K +Q ++ N + + + +R G ++RG
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFT----QMIREGGARSLWRG 245
Query: 69 AAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
+N+ + PE AIK A + + + D + L + + ++AG AG PME+LK
Sbjct: 246 NGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 305
Query: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYK 188
++ A RK G L R +L G+A YK
Sbjct: 306 TRM-------ALRKTGQYSGMLDC---------------------ARRILAREGVAAFYK 337
Query: 189 GLGATLLRDVPFSVVYFPLFANLNQ--LGRPASEEKSP-FYVSFLAGCVAGSAAAVAVNP 245
G +L +P++ + ++ L L A P +V G ++ + +A P
Sbjct: 338 GYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYP 397
Query: 246 CDVVKTRLQSLQ--RGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQ 303
+V+TR+Q+ G E T S + + ILR EG +G + + P I+
Sbjct: 398 LALVRTRMQAQASIEGAPEVTMSSLF---KHILRTEGAFGLYRGLAPNFMKVIPAVSISY 454
Query: 304 VVY 306
VVY
Sbjct: 455 VVY 457
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/202 (28%), Positives = 93/202 (46%), Gaps = 32/202 (15%)
Query: 105 KEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPA 164
+ ++AG GAG T P++ LK+ +Q + I+ Q+ +GGA+
Sbjct: 188 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR------- 240
Query: 165 APRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSP 224
L++G G +L+ P S + F + + +L + +E
Sbjct: 241 --------------------SLWRGNGINVLKIAPESAIKFMAYEQIKRL-VGSDQETLR 279
Query: 225 FYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAF 284
+ +AG +AG+ A ++ P +V+KTR+ + G YSG+LDCAR+IL EG +AF
Sbjct: 280 IHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG----QYSGMLDCARRILAREGVAAF 335
Query: 285 LKGAYCRALVIAPLFGIAQVVY 306
KG L I P GI VY
Sbjct: 336 YKGYVPNMLGIIPYAGIDLAVY 357
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 37/208 (17%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
+L+ G +AG I + ++P+++ KTR+ ++ GQ Y+ M DC + + EG Y+G
Sbjct: 283 RLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQ--YSGMLDCARRILAREGVAAFYKGYV 340
Query: 71 VNLTLVTPEKAIKLAA-----NDFFRHQLSKDGQKLTLLKEMLAGCG--AGTCQVIVTTP 123
N+ + P I LA N + +H + L CG + TC + + P
Sbjct: 341 PNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV---LLACGTMSSTCGQLASYP 397
Query: 124 MEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGI 183
+ +++ ++Q AQ S+E AP T + L + +LR+ G
Sbjct: 398 LALVRTRMQ-----------------------AQASIEG--APEVTMSSLFKHILRTEGA 432
Query: 184 AGLYKGLGATLLRDVPFSVVYFPLFANL 211
GLY+GL ++ +P + + ++ NL
Sbjct: 433 FGLYRGLAPNFMKVIPAVSISYVVYENL 460
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 82.4 bits (202), Expect = 5e-16
Identities = 75/303 (24%), Positives = 125/303 (41%), Gaps = 43/303 (14%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQ---NQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
L+ GG AG + TC P+D K +Q ++ N + + + +R G ++RG
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFT----QMIREGGARSLWRG 279
Query: 69 AAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
+N+ + PE AIK A + + + D + L + + ++AG AG PME+LK
Sbjct: 280 NGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 339
Query: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYK 188
++ A RK G L R +L G+A YK
Sbjct: 340 TRM-------ALRKTGQYSGMLDC---------------------ARRILAREGVAAFYK 371
Query: 189 GLGATLLRDVPFSVVYFPLFANLNQ--LGRPASEEKSP-FYVSFLAGCVAGSAAAVAVNP 245
G +L +P++ + ++ L L A P +V G ++ + +A P
Sbjct: 372 GYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYP 431
Query: 246 CDVVKTRLQSLQ--RGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQ 303
+V+TR+Q+ G E T S + + ILR EG +G + + P I+
Sbjct: 432 LALVRTRMQAQASIEGAPEVTMSSLF---KHILRTEGAFGLYRGLAPNFMKVIPAVSISY 488
Query: 304 VVY 306
VVY
Sbjct: 489 VVY 491
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/202 (28%), Positives = 93/202 (46%), Gaps = 32/202 (15%)
Query: 105 KEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPA 164
+ ++AG GAG T P++ LK+ +Q + I+ Q+ +GGA+
Sbjct: 222 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR------- 274
Query: 165 APRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSP 224
L++G G +L+ P S + F + + +L + +E
Sbjct: 275 --------------------SLWRGNGINVLKIAPESAIKFMAYEQIKRL-VGSDQETLR 313
Query: 225 FYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAF 284
+ +AG +AG+ A ++ P +V+KTR+ + G YSG+LDCAR+IL EG +AF
Sbjct: 314 IHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG----QYSGMLDCARRILAREGVAAF 369
Query: 285 LKGAYCRALVIAPLFGIAQVVY 306
KG L I P GI VY
Sbjct: 370 YKGYVPNMLGIIPYAGIDLAVY 391
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 37/208 (17%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
+L+ G +AG I + ++P+++ KTR+ ++ GQ Y+ M DC + + EG Y+G
Sbjct: 317 RLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQ--YSGMLDCARRILAREGVAAFYKGYV 374
Query: 71 VNLTLVTPEKAIKLAA-----NDFFRHQLSKDGQKLTLLKEMLAGCG--AGTCQVIVTTP 123
N+ + P I LA N + +H + L CG + TC + + P
Sbjct: 375 PNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV---LLACGTMSSTCGQLASYP 431
Query: 124 MEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGI 183
+ +++ ++Q AQ S+E AP T + L + +LR+ G
Sbjct: 432 LALVRTRMQ-----------------------AQASIEG--APEVTMSSLFKHILRTEGA 466
Query: 184 AGLYKGLGATLLRDVPFSVVYFPLFANL 211
GLY+GL ++ +P + + ++ NL
Sbjct: 467 FGLYRGLAPNFMKVIPAVSISYVVYENL 494
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 82.4 bits (202), Expect = 5e-16
Identities = 75/303 (24%), Positives = 125/303 (41%), Gaps = 43/303 (14%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQ---NQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
L+ GG AG + TC P+D K +Q ++ N + + + +R G ++RG
Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFT----QMIREGGARSLWRG 265
Query: 69 AAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
+N+ + PE AIK A + + + D + L + + ++AG AG PME+LK
Sbjct: 266 NGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 325
Query: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYK 188
++ A RK G L R +L G+A YK
Sbjct: 326 TRM-------ALRKTGQYSGMLDC---------------------ARRILAREGVAAFYK 357
Query: 189 GLGATLLRDVPFSVVYFPLFANLNQ--LGRPASEEKSP-FYVSFLAGCVAGSAAAVAVNP 245
G +L +P++ + ++ L L A P +V G ++ + +A P
Sbjct: 358 GYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYP 417
Query: 246 CDVVKTRLQSLQ--RGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQ 303
+V+TR+Q+ G E T S + + ILR EG +G + + P I+
Sbjct: 418 LALVRTRMQAQASIEGAPEVTMSSLF---KHILRTEGAFGLYRGLAPNFMKVIPAVSISY 474
Query: 304 VVY 306
VVY
Sbjct: 475 VVY 477
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/202 (28%), Positives = 93/202 (46%), Gaps = 32/202 (15%)
Query: 105 KEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPA 164
+ ++AG GAG T P++ LK+ +Q + I+ Q+ +GGA+
Sbjct: 208 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR------- 260
Query: 165 APRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSP 224
L++G G +L+ P S + F + + +L + +E
Sbjct: 261 --------------------SLWRGNGINVLKIAPESAIKFMAYEQIKRL-VGSDQETLR 299
Query: 225 FYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAF 284
+ +AG +AG+ A ++ P +V+KTR+ + G YSG+LDCAR+IL EG +AF
Sbjct: 300 IHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG----QYSGMLDCARRILAREGVAAF 355
Query: 285 LKGAYCRALVIAPLFGIAQVVY 306
KG L I P GI VY
Sbjct: 356 YKGYVPNMLGIIPYAGIDLAVY 377
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 37/208 (17%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
+L+ G +AG I + ++P+++ KTR+ ++ GQ Y+ M DC + + EG Y+G
Sbjct: 303 RLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQ--YSGMLDCARRILAREGVAAFYKGYV 360
Query: 71 VNLTLVTPEKAIKLAA-----NDFFRHQLSKDGQKLTLLKEMLAGCG--AGTCQVIVTTP 123
N+ + P I LA N + +H + L CG + TC + + P
Sbjct: 361 PNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV---LLACGTMSSTCGQLASYP 417
Query: 124 MEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGI 183
+ +++ ++Q AQ S+E AP T + L + +LR+ G
Sbjct: 418 LALVRTRMQ-----------------------AQASIEG--APEVTMSSLFKHILRTEGA 452
Query: 184 AGLYKGLGATLLRDVPFSVVYFPLFANL 211
GLY+GL ++ +P + + ++ NL
Sbjct: 453 FGLYRGLAPNFMKVIPAVSISYVVYENL 480
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 82.4 bits (202), Expect = 5e-16
Identities = 75/303 (24%), Positives = 125/303 (41%), Gaps = 43/303 (14%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQ---NQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
L+ GG AG + TC P+D K +Q ++ N + + + +R G ++RG
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFT----QMIREGGARSLWRG 245
Query: 69 AAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
+N+ + PE AIK A + + + D + L + + ++AG AG PME+LK
Sbjct: 246 NGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 305
Query: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYK 188
++ A RK G L R +L G+A YK
Sbjct: 306 TRM-------ALRKTGQYSGMLDC---------------------ARRILAREGVAAFYK 337
Query: 189 GLGATLLRDVPFSVVYFPLFANLNQ--LGRPASEEKSP-FYVSFLAGCVAGSAAAVAVNP 245
G +L +P++ + ++ L L A P +V G ++ + +A P
Sbjct: 338 GYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYP 397
Query: 246 CDVVKTRLQSLQ--RGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQ 303
+V+TR+Q+ G E T S + + ILR EG +G + + P I+
Sbjct: 398 LALVRTRMQAQASIEGAPEVTMSSLF---KHILRTEGAFGLYRGLAPNFMKVIPAVSISY 454
Query: 304 VVY 306
VVY
Sbjct: 455 VVY 457
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/202 (28%), Positives = 93/202 (46%), Gaps = 32/202 (15%)
Query: 105 KEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPA 164
+ ++AG GAG T P++ LK+ +Q + I+ Q+ +GGA+
Sbjct: 188 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR------- 240
Query: 165 APRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSP 224
L++G G +L+ P S + F + + +L + +E
Sbjct: 241 --------------------SLWRGNGINVLKIAPESAIKFMAYEQIKRL-VGSDQETLR 279
Query: 225 FYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAF 284
+ +AG +AG+ A ++ P +V+KTR+ + G YSG+LDCAR+IL EG +AF
Sbjct: 280 IHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG----QYSGMLDCARRILAREGVAAF 335
Query: 285 LKGAYCRALVIAPLFGIAQVVY 306
KG L I P GI VY
Sbjct: 336 YKGYVPNMLGIIPYAGIDLAVY 357
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 37/208 (17%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
+L+ G +AG I + ++P+++ KTR+ ++ GQ Y+ M DC + + EG Y+G
Sbjct: 283 RLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQ--YSGMLDCARRILAREGVAAFYKGYV 340
Query: 71 VNLTLVTPEKAIKLAA-----NDFFRHQLSKDGQKLTLLKEMLAGCG--AGTCQVIVTTP 123
N+ + P I LA N + +H + L CG + TC + + P
Sbjct: 341 PNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV---LLACGTMSSTCGQLASYP 397
Query: 124 MEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGI 183
+ +++ ++Q AQ S+E AP T + L + +LR+ G
Sbjct: 398 LALVRTRMQ-----------------------AQASIEG--APEVTMSSLFKHILRTEGA 432
Query: 184 AGLYKGLGATLLRDVPFSVVYFPLFANL 211
GLY+GL ++ +P + + ++ NL
Sbjct: 433 FGLYRGLAPNFMKVIPAVSISYVVYENL 460
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 82.4 bits (202), Expect = 5e-16
Identities = 75/303 (24%), Positives = 125/303 (41%), Gaps = 43/303 (14%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQ---NQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
L+ GG AG + TC P+D K +Q ++ N + + + +R G ++RG
Sbjct: 87 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFT----QMIREGGARSLWRG 142
Query: 69 AAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
+N+ + PE AIK A + + + D + L + + ++AG AG PME+LK
Sbjct: 143 NGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 202
Query: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYK 188
++ A RK G L R +L G+A YK
Sbjct: 203 TRM-------ALRKTGQYSGMLDC---------------------ARRILAREGVAAFYK 234
Query: 189 GLGATLLRDVPFSVVYFPLFANLNQ--LGRPASEEKSP-FYVSFLAGCVAGSAAAVAVNP 245
G +L +P++ + ++ L L A P +V G ++ + +A P
Sbjct: 235 GYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYP 294
Query: 246 CDVVKTRLQSLQ--RGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQ 303
+V+TR+Q+ G E T S + + ILR EG +G + + P I+
Sbjct: 295 LALVRTRMQAQASIEGAPEVTMSSLF---KHILRTEGAFGLYRGLAPNFMKVIPAVSISY 351
Query: 304 VVY 306
VVY
Sbjct: 352 VVY 354
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/202 (28%), Positives = 93/202 (46%), Gaps = 32/202 (15%)
Query: 105 KEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPA 164
+ ++AG GAG T P++ LK+ +Q + I+ Q+ +GGA+
Sbjct: 85 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR------- 137
Query: 165 APRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSP 224
L++G G +L+ P S + F + + +L + +E
Sbjct: 138 --------------------SLWRGNGINVLKIAPESAIKFMAYEQIKRL-VGSDQETLR 176
Query: 225 FYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAF 284
+ +AG +AG+ A ++ P +V+KTR+ + G YSG+LDCAR+IL EG +AF
Sbjct: 177 IHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG----QYSGMLDCARRILAREGVAAF 232
Query: 285 LKGAYCRALVIAPLFGIAQVVY 306
KG L I P GI VY
Sbjct: 233 YKGYVPNMLGIIPYAGIDLAVY 254
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 37/208 (17%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
+L+ G +AG I + ++P+++ KTR+ ++ GQ Y+ M DC + + EG Y+G
Sbjct: 180 RLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQ--YSGMLDCARRILAREGVAAFYKGYV 237
Query: 71 VNLTLVTPEKAIKLAA-----NDFFRHQLSKDGQKLTLLKEMLAGCG--AGTCQVIVTTP 123
N+ + P I LA N + +H + L CG + TC + + P
Sbjct: 238 PNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV---LLACGTMSSTCGQLASYP 294
Query: 124 MEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGI 183
+ +++ ++Q AQ S+E AP T + L + +LR+ G
Sbjct: 295 LALVRTRMQ-----------------------AQASIEG--APEVTMSSLFKHILRTEGA 329
Query: 184 AGLYKGLGATLLRDVPFSVVYFPLFANL 211
GLY+GL ++ +P + + ++ NL
Sbjct: 330 FGLYRGLAPNFMKVIPAVSISYVVYENL 357
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 82.4 bits (202), Expect = 5e-16
Identities = 75/303 (24%), Positives = 125/303 (41%), Gaps = 43/303 (14%)
Query: 12 LINGGIAGLIGVTCVFPIDLAKTRLQ---NQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
L+ GG AG + TC P+D K +Q ++ N + + + +R G ++RG
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFT----QMIREGGARSLWRG 279
Query: 69 AAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEMLK 128
+N+ + PE AIK A + + + D + L + + ++AG AG PME+LK
Sbjct: 280 NGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLK 339
Query: 129 IQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIAGLYK 188
++ A RK G L R +L G+A YK
Sbjct: 340 TRM-------ALRKTGQYSGMLDC---------------------ARRILAREGVAAFYK 371
Query: 189 GLGATLLRDVPFSVVYFPLFANLNQ--LGRPASEEKSP-FYVSFLAGCVAGSAAAVAVNP 245
G +L +P++ + ++ L L A P +V G ++ + +A P
Sbjct: 372 GYVPNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYP 431
Query: 246 CDVVKTRLQSLQ--RGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGIAQ 303
+V+TR+Q+ G E T S + + ILR EG +G + + P I+
Sbjct: 432 LALVRTRMQAQASIEGAPEVTMSSLF---KHILRTEGAFGLYRGLAPNFMKVIPAVSISY 488
Query: 304 VVY 306
VVY
Sbjct: 489 VVY 491
Score = 79.3 bits (194), Expect = 4e-15
Identities = 58/202 (28%), Positives = 93/202 (46%), Gaps = 32/202 (15%)
Query: 105 KEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPA 164
+ ++AG GAG T P++ LK+ +Q + I+ Q+ +GGA+
Sbjct: 222 RHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR------- 274
Query: 165 APRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSP 224
L++G G +L+ P S + F + + +L + +E
Sbjct: 275 --------------------SLWRGNGINVLKIAPESAIKFMAYEQIKRL-VGSDQETLR 313
Query: 225 FYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAF 284
+ +AG +AG+ A ++ P +V+KTR+ + G YSG+LDCAR+IL EG +AF
Sbjct: 314 IHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTG----QYSGMLDCARRILAREGVAAF 369
Query: 285 LKGAYCRALVIAPLFGIAQVVY 306
KG L I P GI VY
Sbjct: 370 YKGYVPNMLGIIPYAGIDLAVY 391
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/208 (25%), Positives = 95/208 (45%), Gaps = 37/208 (17%)
Query: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
+L+ G +AG I + ++P+++ KTR+ ++ GQ Y+ M DC + + EG Y+G
Sbjct: 317 RLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQ--YSGMLDCARRILAREGVAAFYKGYV 374
Query: 71 VNLTLVTPEKAIKLAA-----NDFFRHQLSKDGQKLTLLKEMLAGCG--AGTCQVIVTTP 123
N+ + P I LA N + +H + L CG + TC + + P
Sbjct: 375 PNMLGIIPYAGIDLAVYETLKNAWLQHYAVNSADPGVFV---LLACGTMSSTCGQLASYP 431
Query: 124 MEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGI 183
+ +++ ++Q AQ S+E AP T + L + +LR+ G
Sbjct: 432 LALVRTRMQ-----------------------AQASIEG--APEVTMSSLFKHILRTEGA 466
Query: 184 AGLYKGLGATLLRDVPFSVVYFPLFANL 211
GLY+GL ++ +P + + ++ NL
Sbjct: 467 FGLYRGLAPNFMKVIPAVSISYVVYENL 494
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,358,255
Number of Sequences: 37866
Number of extensions: 474158
Number of successful extensions: 2025
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 1353
Number of HSP's gapped (non-prelim): 336
length of query: 323
length of database: 18,247,518
effective HSP length: 102
effective length of query: 221
effective length of database: 14,385,186
effective search space: 3179126106
effective search space used: 3179126106
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.