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Search of human proteins with 4557691
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557691 Kell blood group, metallo-endopeptidase [Homo
sapiens]
(732 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens] 1491 0.0
gi|153945836 endothelin converting enzyme 2 isoform E [Homo sapi... 359 4e-99
gi|153945771 endothelin converting enzyme 2 isoform D [Homo sapi... 359 4e-99
gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens] 359 4e-99
gi|153945761 endothelin converting enzyme 2 isoform A [Homo sapi... 359 4e-99
gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo sapi... 351 1e-96
gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo sapi... 351 1e-96
gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo sapi... 351 1e-96
gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens] 351 1e-96
gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens] 278 2e-74
gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens] 253 4e-67
gi|116256333 membrane metallo-endopeptidase [Homo sapiens] 216 6e-56
gi|116256331 membrane metallo-endopeptidase [Homo sapiens] 216 6e-56
gi|116256327 membrane metallo-endopeptidase [Homo sapiens] 216 6e-56
gi|116256329 membrane metallo-endopeptidase [Homo sapiens] 216 6e-56
gi|90403592 phosphate-regulating neutral endopeptidase [Homo sap... 209 1e-53
gi|118498356 kinectin 1 isoform a [Homo sapiens] 30 6.1
gi|118498368 kinectin 1 isoform c [Homo sapiens] 30 6.1
gi|33620775 kinectin 1 isoform a [Homo sapiens] 30 6.1
gi|45545435 COMM domain containing 2 [Homo sapiens] 30 8.0
>gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens]
Length = 732
Score = 1491 bits (3859), Expect = 0.0
Identities = 732/732 (100%), Positives = 732/732 (100%)
Query: 1 MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLC 60
MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLC
Sbjct: 1 MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLC 60
Query: 61 FSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQE 120
FSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQE
Sbjct: 61 FSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQE 120
Query: 121 LATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWR 180
LATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWR
Sbjct: 121 LATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWR 180
Query: 181 ISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQ 240
ISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQ
Sbjct: 181 ISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQ 240
Query: 241 KIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQ 300
KIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQ
Sbjct: 241 KIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQ 300
Query: 301 MVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDF 360
MVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDF
Sbjct: 301 MVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDF 360
Query: 361 LQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEP 420
LQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEP
Sbjct: 361 LQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEP 420
Query: 421 TLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG 480
TLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG
Sbjct: 421 TLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG 480
Query: 481 ASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVN 540
ASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVN
Sbjct: 481 ASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVN 540
Query: 541 AYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACD 600
AYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACD
Sbjct: 541 AYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACD 600
Query: 601 NHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGET 660
NHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGET
Sbjct: 601 NHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGET 660
Query: 661 VLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARG 720
VLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARG
Sbjct: 661 VLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARG 720
Query: 721 ALLNPSSRCQLW 732
ALLNPSSRCQLW
Sbjct: 721 ALLNPSSRCQLW 732
>gi|153945836 endothelin converting enzyme 2 isoform E [Homo
sapiens]
Length = 765
Score = 359 bits (922), Expect = 4e-99
Identities = 224/718 (31%), Positives = 355/718 (49%), Gaps = 53/718 (7%)
Query: 48 VLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFA 107
+L A L+LG L+ V ++ C T C+ + L S + V+PC DF+ F+
Sbjct: 68 LLLAALLLGCLVALGVQYH---RDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFS 124
Query: 108 CGRAKETN---------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDT 158
CG N N+F L +N+ L+ +LE E+K +FY SC+
Sbjct: 125 CGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQV 184
Query: 159 LAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASP 218
IE G PLR +IE++GGW I+G W NF L+ + Y PFF Y+ S
Sbjct: 185 ERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSS 244
Query: 219 HTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSS 273
++ VIQ+DQ P D L + +K + YL Y+ +LG LLGG P+ +E
Sbjct: 245 NSNVIQVDQSGLFLPSRDYYLNRTANEK----VLTAYLDYMEELGMLLGGRPTSTREQMQ 300
Query: 274 LSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQ 333
+ + +L P +QRR + K++ ++I +L+ +AP++DWL L +P+ LS S+
Sbjct: 301 QVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSE 360
Query: 334 SLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLR 393
+VV+ ++YL+ +S+L+ + L +++I LV + +LD +F+ A+ KL + L
Sbjct: 361 PVVVYGMDYLQQVSELINR---TEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLY 417
Query: 394 ELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITR 453
+ PRW C+ T L +LFV+ F ++ A + + IR A
Sbjct: 418 GTKKS----CVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 473
Query: 454 LRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLG-SSFLQSVLSCV 512
L L WM+E+T+ A++K + +G ++ L+P+ Y+ ++ SF Q++L+
Sbjct: 474 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 533
Query: 513 RSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNF 572
+ +P + +W ++P VNAYY + + +VFPAG+LQ PF+ +P+A+NF
Sbjct: 534 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 593
Query: 573 GAAGSIMAHELLHIFYQL---------LLP----GGCLACDNHALQEAHLCLKRHYAAFP 619
G G +M HEL H F L P A NH C++ Y +
Sbjct: 594 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHT-----ACMEEQYNQYQ 648
Query: 620 LPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQ 679
+ + N T EN AD GGL A AY L +H E LP++ L+ Q+FF +AQ
Sbjct: 649 V-NGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQ 707
Query: 680 VMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 732
V C +P+ SH D HSP RV G LS++ F R+F C G+ +NP C++W
Sbjct: 708 VWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 765
>gi|153945771 endothelin converting enzyme 2 isoform D [Homo
sapiens]
Length = 811
Score = 359 bits (922), Expect = 4e-99
Identities = 224/718 (31%), Positives = 355/718 (49%), Gaps = 53/718 (7%)
Query: 48 VLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFA 107
+L A L+LG L+ V ++ C T C+ + L S + V+PC DF+ F+
Sbjct: 114 LLLAALLLGCLVALGVQYH---RDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFS 170
Query: 108 CGRAKETN---------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDT 158
CG N N+F L +N+ L+ +LE E+K +FY SC+
Sbjct: 171 CGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQV 230
Query: 159 LAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASP 218
IE G PLR +IE++GGW I+G W NF L+ + Y PFF Y+ S
Sbjct: 231 ERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSS 290
Query: 219 HTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSS 273
++ VIQ+DQ P D L + +K + YL Y+ +LG LLGG P+ +E
Sbjct: 291 NSNVIQVDQSGLFLPSRDYYLNRTANEK----VLTAYLDYMEELGMLLGGRPTSTREQMQ 346
Query: 274 LSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQ 333
+ + +L P +QRR + K++ ++I +L+ +AP++DWL L +P+ LS S+
Sbjct: 347 QVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSE 406
Query: 334 SLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLR 393
+VV+ ++YL+ +S+L+ + L +++I LV + +LD +F+ A+ KL + L
Sbjct: 407 PVVVYGMDYLQQVSELINR---TEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLY 463
Query: 394 ELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITR 453
+ PRW C+ T L +LFV+ F ++ A + + IR A
Sbjct: 464 GTKKS----CVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 519
Query: 454 LRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLG-SSFLQSVLSCV 512
L L WM+E+T+ A++K + +G ++ L+P+ Y+ ++ SF Q++L+
Sbjct: 520 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 579
Query: 513 RSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNF 572
+ +P + +W ++P VNAYY + + +VFPAG+LQ PF+ +P+A+NF
Sbjct: 580 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 639
Query: 573 GAAGSIMAHELLHIFYQL---------LLP----GGCLACDNHALQEAHLCLKRHYAAFP 619
G G +M HEL H F L P A NH C++ Y +
Sbjct: 640 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHT-----ACMEEQYNQYQ 694
Query: 620 LPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQ 679
+ + N T EN AD GGL A AY L +H E LP++ L+ Q+FF +AQ
Sbjct: 695 V-NGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQ 753
Query: 680 VMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 732
V C +P+ SH D HSP RV G LS++ F R+F C G+ +NP C++W
Sbjct: 754 VWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811
>gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens]
Length = 736
Score = 359 bits (922), Expect = 4e-99
Identities = 224/718 (31%), Positives = 355/718 (49%), Gaps = 53/718 (7%)
Query: 48 VLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFA 107
+L A L+LG L+ V ++ C T C+ + L S + V+PC DF+ F+
Sbjct: 39 LLLAALLLGCLVALGVQYH---RDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFS 95
Query: 108 CGRAKETN---------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDT 158
CG N N+F L +N+ L+ +LE E+K +FY SC+
Sbjct: 96 CGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQV 155
Query: 159 LAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASP 218
IE G PLR +IE++GGW I+G W NF L+ + Y PFF Y+ S
Sbjct: 156 ERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSS 215
Query: 219 HTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSS 273
++ VIQ+DQ P D L + +K + YL Y+ +LG LLGG P+ +E
Sbjct: 216 NSNVIQVDQSGLFLPSRDYYLNRTANEK----VLTAYLDYMEELGMLLGGRPTSTREQMQ 271
Query: 274 LSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQ 333
+ + +L P +QRR + K++ ++I +L+ +AP++DWL L +P+ LS S+
Sbjct: 272 QVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSE 331
Query: 334 SLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLR 393
+VV+ ++YL+ +S+L+ + L +++I LV + +LD +F+ A+ KL + L
Sbjct: 332 PVVVYGMDYLQQVSELINR---TEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLY 388
Query: 394 ELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITR 453
+ PRW C+ T L +LFV+ F ++ A + + IR A
Sbjct: 389 GTKKS----CVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 444
Query: 454 LRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLG-SSFLQSVLSCV 512
L L WM+E+T+ A++K + +G ++ L+P+ Y+ ++ SF Q++L+
Sbjct: 445 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 504
Query: 513 RSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNF 572
+ +P + +W ++P VNAYY + + +VFPAG+LQ PF+ +P+A+NF
Sbjct: 505 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 564
Query: 573 GAAGSIMAHELLHIFYQL---------LLP----GGCLACDNHALQEAHLCLKRHYAAFP 619
G G +M HEL H F L P A NH C++ Y +
Sbjct: 565 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHT-----ACMEEQYNQYQ 619
Query: 620 LPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQ 679
+ + N T EN AD GGL A AY L +H E LP++ L+ Q+FF +AQ
Sbjct: 620 V-NGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQ 678
Query: 680 VMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 732
V C +P+ SH D HSP RV G LS++ F R+F C G+ +NP C++W
Sbjct: 679 VWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
>gi|153945761 endothelin converting enzyme 2 isoform A [Homo
sapiens]
Length = 883
Score = 359 bits (922), Expect = 4e-99
Identities = 224/718 (31%), Positives = 355/718 (49%), Gaps = 53/718 (7%)
Query: 48 VLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFA 107
+L A L+LG L+ V ++ C T C+ + L S + V+PC DF+ F+
Sbjct: 186 LLLAALLLGCLVALGVQYH---RDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFS 242
Query: 108 CGRAKETN---------NSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDT 158
CG N N+F L +N+ L+ +LE E+K +FY SC+
Sbjct: 243 CGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQV 302
Query: 159 LAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASP 218
IE G PLR +IE++GGW I+G W NF L+ + Y PFF Y+ S
Sbjct: 303 ERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSS 362
Query: 219 HTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSS 273
++ VIQ+DQ P D L + +K + YL Y+ +LG LLGG P+ +E
Sbjct: 363 NSNVIQVDQSGLFLPSRDYYLNRTANEK----VLTAYLDYMEELGMLLGGRPTSTREQMQ 418
Query: 274 LSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQ 333
+ + +L P +QRR + K++ ++I +L+ +AP++DWL L +P+ LS S+
Sbjct: 419 QVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSE 478
Query: 334 SLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLR 393
+VV+ ++YL+ +S+L+ + L +++I LV + +LD +F+ A+ KL + L
Sbjct: 479 PVVVYGMDYLQQVSELINR---TEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLY 535
Query: 394 ELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITR 453
+ PRW C+ T L +LFV+ F ++ A + + IR A
Sbjct: 536 GTKKS----CVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 591
Query: 454 LRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLG-SSFLQSVLSCV 512
L L WM+E+T+ A++K + +G ++ L+P+ Y+ ++ SF Q++L+
Sbjct: 592 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 651
Query: 513 RSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNF 572
+ +P + +W ++P VNAYY + + +VFPAG+LQ PF+ +P+A+NF
Sbjct: 652 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 711
Query: 573 GAAGSIMAHELLHIFYQL---------LLP----GGCLACDNHALQEAHLCLKRHYAAFP 619
G G +M HEL H F L P A NH C++ Y +
Sbjct: 712 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHT-----ACMEEQYNQYQ 766
Query: 620 LPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQ 679
+ + N T EN AD GGL A AY L +H E LP++ L+ Q+FF +AQ
Sbjct: 767 V-NGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQ 825
Query: 680 VMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 732
V C +P+ SH D HSP RV G LS++ F R+F C G+ +NP C++W
Sbjct: 826 VWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 883
>gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo
sapiens]
Length = 767
Score = 351 bits (901), Expect = 1e-96
Identities = 230/733 (31%), Positives = 359/733 (48%), Gaps = 49/733 (6%)
Query: 35 PVEGSRPWAVARRV------LTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDH 88
P G R WA +V L +L GL+ C + L +Q P C + C+ +
Sbjct: 49 PRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGI-QYQTRSPSVCLSEACVSVTSS 107
Query: 89 YLASGNTSVAPCTDFFSFACGRAKETN---------NSFQELATKNKNRLRRILEVQNSW 139
L+S + +V PC DFFS+ACG + N +F L N+ ++ +LE ++
Sbjct: 108 ILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLE-NSTA 166
Query: 140 HPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMS 199
E KA +Y +CM+ IE PL ++IE LGGW I+G W NF TL+++ +
Sbjct: 167 SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTA 226
Query: 200 QYGHFPFFRAYLGPHPASPHTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYL 254
Y PFF Y+ + ++ VIQ+DQ P D L + + +K + YL Y+
Sbjct: 227 HYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEK----VLTGYLNYM 282
Query: 255 NQLGTLL-GGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPA 313
QLG LL GGD ++ + + L P E+RR + ++ VT +L+ +APA
Sbjct: 283 VQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPA 342
Query: 314 IDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTL 373
I+WL L F P+ ++ S+ +VV+D EYL+ +S L+ R L ++MI LV
Sbjct: 343 INWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLIN---TTDRCLLNNYMIWNLVRKT 399
Query: 374 SPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGP 433
S LD +FQ+A +K E+ PRW CV +T L +FV+ F
Sbjct: 400 SSFLDQRFQDA----DEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAE 455
Query: 434 STRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQ 493
++S A ++ I+ A L L WM+EET+ A++K + +G + + P+ +
Sbjct: 456 DSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDK 515
Query: 494 EYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHP-QHRWKVSPWDVNAYYSVSDHVVVF 552
+ND + R+ L+ P + +W ++P VNAYYS + + +VF
Sbjct: 516 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVF 575
Query: 553 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF----YQLLLPGGCLACDNHALQEAH 608
PAG+LQ PF+ P+A+NFG G ++ HEL H F + G ++ EA
Sbjct: 576 PAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAF 635
Query: 609 L----CLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPS 664
C+ Y+ + + + N T EN AD GGL A +AY + ++ E LP+
Sbjct: 636 KRQTECMVEQYSNYSV-NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPT 694
Query: 665 LDLSPQQIFFRSYAQVMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCAR 719
L L+ Q+FF +AQV C +P+ SH D HSP RV G LS++ F+ +FRC
Sbjct: 695 LGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPP 754
Query: 720 GALLNPSSRCQLW 732
G+ +NP +C++W
Sbjct: 755 GSPMNPPHKCEVW 767
>gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo
sapiens]
Length = 754
Score = 351 bits (901), Expect = 1e-96
Identities = 230/733 (31%), Positives = 359/733 (48%), Gaps = 49/733 (6%)
Query: 35 PVEGSRPWAVARRV------LTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDH 88
P G R WA +V L +L GL+ C + L +Q P C + C+ +
Sbjct: 36 PRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGI-QYQTRSPSVCLSEACVSVTSS 94
Query: 89 YLASGNTSVAPCTDFFSFACGRAKETN---------NSFQELATKNKNRLRRILEVQNSW 139
L+S + +V PC DFFS+ACG + N +F L N+ ++ +LE ++
Sbjct: 95 ILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLE-NSTA 153
Query: 140 HPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMS 199
E KA +Y +CM+ IE PL ++IE LGGW I+G W NF TL+++ +
Sbjct: 154 SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTA 213
Query: 200 QYGHFPFFRAYLGPHPASPHTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYL 254
Y PFF Y+ + ++ VIQ+DQ P D L + + +K + YL Y+
Sbjct: 214 HYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEK----VLTGYLNYM 269
Query: 255 NQLGTLL-GGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPA 313
QLG LL GGD ++ + + L P E+RR + ++ VT +L+ +APA
Sbjct: 270 VQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPA 329
Query: 314 IDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTL 373
I+WL L F P+ ++ S+ +VV+D EYL+ +S L+ R L ++MI LV
Sbjct: 330 INWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLIN---TTDRCLLNNYMIWNLVRKT 386
Query: 374 SPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGP 433
S LD +FQ+A +K E+ PRW CV +T L +FV+ F
Sbjct: 387 SSFLDQRFQDA----DEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAE 442
Query: 434 STRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQ 493
++S A ++ I+ A L L WM+EET+ A++K + +G + + P+ +
Sbjct: 443 DSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDK 502
Query: 494 EYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHP-QHRWKVSPWDVNAYYSVSDHVVVF 552
+ND + R+ L+ P + +W ++P VNAYYS + + +VF
Sbjct: 503 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVF 562
Query: 553 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF----YQLLLPGGCLACDNHALQEAH 608
PAG+LQ PF+ P+A+NFG G ++ HEL H F + G ++ EA
Sbjct: 563 PAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAF 622
Query: 609 L----CLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPS 664
C+ Y+ + + + N T EN AD GGL A +AY + ++ E LP+
Sbjct: 623 KRQTECMVEQYSNYSV-NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPT 681
Query: 665 LDLSPQQIFFRSYAQVMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCAR 719
L L+ Q+FF +AQV C +P+ SH D HSP RV G LS++ F+ +FRC
Sbjct: 682 LGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPP 741
Query: 720 GALLNPSSRCQLW 732
G+ +NP +C++W
Sbjct: 742 GSPMNPPHKCEVW 754
>gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo
sapiens]
Length = 758
Score = 351 bits (901), Expect = 1e-96
Identities = 230/733 (31%), Positives = 359/733 (48%), Gaps = 49/733 (6%)
Query: 35 PVEGSRPWAVARRV------LTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDH 88
P G R WA +V L +L GL+ C + L +Q P C + C+ +
Sbjct: 40 PRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGI-QYQTRSPSVCLSEACVSVTSS 98
Query: 89 YLASGNTSVAPCTDFFSFACGRAKETN---------NSFQELATKNKNRLRRILEVQNSW 139
L+S + +V PC DFFS+ACG + N +F L N+ ++ +LE ++
Sbjct: 99 ILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLE-NSTA 157
Query: 140 HPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMS 199
E KA +Y +CM+ IE PL ++IE LGGW I+G W NF TL+++ +
Sbjct: 158 SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTA 217
Query: 200 QYGHFPFFRAYLGPHPASPHTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYL 254
Y PFF Y+ + ++ VIQ+DQ P D L + + +K + YL Y+
Sbjct: 218 HYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEK----VLTGYLNYM 273
Query: 255 NQLGTLL-GGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPA 313
QLG LL GGD ++ + + L P E+RR + ++ VT +L+ +APA
Sbjct: 274 VQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPA 333
Query: 314 IDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTL 373
I+WL L F P+ ++ S+ +VV+D EYL+ +S L+ R L ++MI LV
Sbjct: 334 INWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLIN---TTDRCLLNNYMIWNLVRKT 390
Query: 374 SPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGP 433
S LD +FQ+A +K E+ PRW CV +T L +FV+ F
Sbjct: 391 SSFLDQRFQDA----DEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAE 446
Query: 434 STRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQ 493
++S A ++ I+ A L L WM+EET+ A++K + +G + + P+ +
Sbjct: 447 DSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDK 506
Query: 494 EYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHP-QHRWKVSPWDVNAYYSVSDHVVVF 552
+ND + R+ L+ P + +W ++P VNAYYS + + +VF
Sbjct: 507 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVF 566
Query: 553 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF----YQLLLPGGCLACDNHALQEAH 608
PAG+LQ PF+ P+A+NFG G ++ HEL H F + G ++ EA
Sbjct: 567 PAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAF 626
Query: 609 L----CLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPS 664
C+ Y+ + + + N T EN AD GGL A +AY + ++ E LP+
Sbjct: 627 KRQTECMVEQYSNYSV-NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPT 685
Query: 665 LDLSPQQIFFRSYAQVMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCAR 719
L L+ Q+FF +AQV C +P+ SH D HSP RV G LS++ F+ +FRC
Sbjct: 686 LGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPP 745
Query: 720 GALLNPSSRCQLW 732
G+ +NP +C++W
Sbjct: 746 GSPMNPPHKCEVW 758
>gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens]
Length = 770
Score = 351 bits (901), Expect = 1e-96
Identities = 230/733 (31%), Positives = 359/733 (48%), Gaps = 49/733 (6%)
Query: 35 PVEGSRPWAVARRV------LTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDH 88
P G R WA +V L +L GL+ C + L +Q P C + C+ +
Sbjct: 52 PRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGI-QYQTRSPSVCLSEACVSVTSS 110
Query: 89 YLASGNTSVAPCTDFFSFACGRAKETN---------NSFQELATKNKNRLRRILEVQNSW 139
L+S + +V PC DFFS+ACG + N +F L N+ ++ +LE ++
Sbjct: 111 ILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLE-NSTA 169
Query: 140 HPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMS 199
E KA +Y +CM+ IE PL ++IE LGGW I+G W NF TL+++ +
Sbjct: 170 SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTA 229
Query: 200 QYGHFPFFRAYLGPHPASPHTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYL 254
Y PFF Y+ + ++ VIQ+DQ P D L + + +K + YL Y+
Sbjct: 230 HYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEK----VLTGYLNYM 285
Query: 255 NQLGTLL-GGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPA 313
QLG LL GGD ++ + + L P E+RR + ++ VT +L+ +APA
Sbjct: 286 VQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPA 345
Query: 314 IDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTL 373
I+WL L F P+ ++ S+ +VV+D EYL+ +S L+ R L ++MI LV
Sbjct: 346 INWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLIN---TTDRCLLNNYMIWNLVRKT 402
Query: 374 SPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGP 433
S LD +FQ+A +K E+ PRW CV +T L +FV+ F
Sbjct: 403 SSFLDQRFQDA----DEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAE 458
Query: 434 STRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQ 493
++S A ++ I+ A L L WM+EET+ A++K + +G + + P+ +
Sbjct: 459 DSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDK 518
Query: 494 EYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHP-QHRWKVSPWDVNAYYSVSDHVVVF 552
+ND + R+ L+ P + +W ++P VNAYYS + + +VF
Sbjct: 519 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVF 578
Query: 553 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF----YQLLLPGGCLACDNHALQEAH 608
PAG+LQ PF+ P+A+NFG G ++ HEL H F + G ++ EA
Sbjct: 579 PAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAF 638
Query: 609 L----CLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPS 664
C+ Y+ + + + N T EN AD GGL A +AY + ++ E LP+
Sbjct: 639 KRQTECMVEQYSNYSV-NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPT 697
Query: 665 LDLSPQQIFFRSYAQVMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCAR 719
L L+ Q+FF +AQV C +P+ SH D HSP RV G LS++ F+ +FRC
Sbjct: 698 LGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPP 757
Query: 720 GALLNPSSRCQLW 732
G+ +NP +C++W
Sbjct: 758 GSPMNPPHKCEVW 770
>gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens]
Length = 775
Score = 278 bits (710), Expect = 2e-74
Identities = 200/697 (28%), Positives = 330/697 (47%), Gaps = 55/697 (7%)
Query: 74 PRPCETSVCLDLRDHYLASG-NTSVAPCTDFFSFACGR---------AKETNNSFQELAT 123
P C +LA+ + S+ PC DF+SFACG K T + +
Sbjct: 96 PEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGE 155
Query: 124 KNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISG 183
+N+ RLRR+L G+ + K F+ SC+D IE G P+ +VIE+ GGW + G
Sbjct: 156 QNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGG 215
Query: 184 ---------KWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQ-----PE 229
+W + NR L Y F + + VI+IDQ PE
Sbjct: 216 AEERPGVAARW---DLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPE 272
Query: 230 FDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPL 289
+ L QD++ + +I Y ++ ++ +LLG D + + L +
Sbjct: 273 RTLYLAQDEDSE---KILAAYRVFMERVLSLLGADAVEQKAQEILQVEQQLANITVSEHD 329
Query: 290 EQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQL 349
+ RR ++ VT+ QL+++ P + W L F S + +V+ +Y++ +SQL
Sbjct: 330 DLRRDVSSMYNKVTLGQLQKITPHLRWKWLLDQIFQE-DFSEEEEVVLLATDYMQQVSQL 388
Query: 350 VEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMK 409
+ L ++++ +VV LS L F+EA +L+Q++ E +++P AR
Sbjct: 389 IRST---PHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEM-EGSDKPQELARV---- 440
Query: 410 CVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQ 469
C+ + F L ALFV E F ++++ +L I+ L RL L WM+ ET+ A+
Sbjct: 441 CLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAAR 500
Query: 470 DKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQ 529
K+ + V +G ++ LKP+ +EY ++ +++L+ +R V+ Q +
Sbjct: 501 AKLQYMMVMVGYPDFLLKPDAVDKEYEFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDK 560
Query: 530 HRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQ 589
W + P +NAYY + + +VFPAG+LQP + P +P+++N+G G+I+ HEL H +
Sbjct: 561 STWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDD 620
Query: 590 L---------LLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVG 640
LL A + L++A C+ R Y F + ++ N T EN AD+G
Sbjct: 621 WGGQYDRSGNLLHWWTEASYSRFLRKAE-CIVRLYDNFTVYNQ-RVNGKHTLGENIADMG 678
Query: 641 GLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSH-----DTHS 695
GL +A AY K + H E LP L + Q+FF ++AQ C K Q + D H+
Sbjct: 679 GLKLAYHAYQKWVREHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHA 738
Query: 696 PPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 732
P H RV G +S F R F C + + +NP+ +C +W
Sbjct: 739 PEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW 775
>gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens]
Length = 779
Score = 253 bits (646), Expect = 4e-67
Identities = 189/700 (27%), Positives = 327/700 (46%), Gaps = 53/700 (7%)
Query: 77 CETSVCLDLRDHYLASGNTSVAPCTDFFSFACGR------AKETNNS---FQELATKNKN 127
C T C+ L + + + PC DF+ FACG ETN+ F L + +
Sbjct: 89 CTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEV 148
Query: 128 RLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRIS-GKWT 186
L+ +LE ++ EKA Y SCM+ IE G+ PL ++E +GGW ++ +W
Sbjct: 149 ILKAVLE-NSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWN 207
Query: 187 SL-----NFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQK 241
R L L+ SQ+ ++ + +I IDQP +P ++
Sbjct: 208 ETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNG 267
Query: 242 IYAQIFRE-YLTYLNQLGTLLGGDPSK------VQEHSSLSISITSRLFQFLRPLEQRRA 294
+ RE YL ++ + TLL D + VQE + + ++L + P E+R
Sbjct: 268 GSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHD 327
Query: 295 QGKLFQMVTIDQLKEM--APAIDWLSCLQATFTPMSLS--PSQSLVVHDVEYLKNMSQLV 350
L+ + +++L+ +W +Q + + + P + +VV+ + YL+N+ ++
Sbjct: 328 VIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENII 387
Query: 351 EEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKC 410
+ + +Q++++ LV+ +L +F++ R + L M RW +C
Sbjct: 388 DTYSART---IQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGT-----MVEEVRWREC 439
Query: 411 VEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQD 470
V + E + +L+VREAF ++S +L +R + L L WM+EE++ AQ+
Sbjct: 440 VGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQE 499
Query: 471 KVAQLQVEMGASEWALKPELAR--QEYNDIQLGSS-FLQSVLSCVRSLRARIVQSFLQPH 527
K ++ ++G ++ L+ R +EY+++ + ++ L ++ R ++ +
Sbjct: 500 KAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKV 559
Query: 528 PQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF 587
+ W + VNA+YS + + +VFPAG+LQPPFF P+A+NFG G ++ HE+ H F
Sbjct: 560 DPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGF 619
Query: 588 ----YQLLLPGGCL----ACDNHALQEAHLCLKRHYA--AFPLPSRTSFNDSLTFLENAA 637
G + +E C+ Y ++ L + N T EN A
Sbjct: 620 DDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIA 679
Query: 638 DVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDS-----HD 692
D GG+ A +AY K + + LP LDL+ +Q+FF +YAQV C P+ + D
Sbjct: 680 DNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTD 739
Query: 693 THSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 732
HSP RV G L + AFA F CARG ++P RC++W
Sbjct: 740 VHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779
>gi|116256333 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 216 bits (550), Expect = 6e-56
Identities = 173/749 (23%), Positives = 332/749 (44%), Gaps = 80/749 (10%)
Query: 42 WAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCT 101
W L+ +++L ++ +++ Y + G C++S C+ + + + + PCT
Sbjct: 24 WTPLEISLSVLVLLLTIIAVTMIALYATYDDGI--CKSSDCIKSAARLIQNMDATTEPCT 81
Query: 102 DFFSFACGRAKETNNSFQELATK--NKNRLRRILEV-------QNSWHPGSGEEKAFQFY 152
DFF +ACG + N E +++ N + LR LEV + +KA Y
Sbjct: 82 DFFKYACGGWLK-RNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALY 140
Query: 153 NSCMDTLAIEAAGTGPLRQVIEELGGWRIS---------GKWTSLNFNRTLRLLMSQYGH 203
SC++ AI++ G PL +++ ++ GW ++ WT+ + + L S+YG
Sbjct: 141 RSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA---EKAIAQLNSKYGK 197
Query: 204 FPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQE-QKIYAQIFREYLTYLNQLGTLLG 262
++G + VI IDQP +P + E IY + Y+ ++ + L+
Sbjct: 198 KVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIR 257
Query: 263 GDPSKVQEHSSLSISITSRLFQFLRPL-------EQRRAQGKLFQMVTIDQLKEM----- 310
+ + + L++ + +++ + + + E R L+ +T+ Q++
Sbjct: 258 QEERLPIDENQLALEM-NKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEI 316
Query: 311 -APAIDWLSCLQATFTPMSLSPS--QSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMIL 367
WL+ + +++S + + +VV+ EYL + ++ + + LQ+ M
Sbjct: 317 NGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARD---LQNLMSW 373
Query: 368 GLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFV 427
++ L +L ++E+R + L T + W +C E + L+V
Sbjct: 374 RFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-----WRRCANYVNGNMENAVGRLYV 428
Query: 428 REAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG------A 481
AF ++ L IR+ I L +L WM+ ET+ A++K ++ +G +
Sbjct: 429 EAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVS 488
Query: 482 SEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNA 541
++ L E Y + + ++++ ++ +++ ++ + + W VNA
Sbjct: 489 NDNKLNNEYLELNYKE----DEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNA 544
Query: 542 YYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDN 601
+YS + +VFPAG+LQPPFF ++N+G G ++ HE+ H F G D
Sbjct: 545 FYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDD---NGRNFNKDG 601
Query: 602 HAL-----------QEAHLCLKRHYAAF--PLPSRTSFNDSLTFLENAADVGGLAIALQA 648
+ +E C+ Y F L N T EN AD GGL A +A
Sbjct: 602 DLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRA 661
Query: 649 YSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDS-----HDTHSPPHLRVHG 703
Y + ++ E +LP LDL+ +Q+FF ++AQV C P+ + D HSP + R+ G
Sbjct: 662 YQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIG 721
Query: 704 PLSSTPAFARYFRCARGALLNPSSRCQLW 732
L ++ F+ F C + + +NP +C++W
Sbjct: 722 TLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|116256331 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 216 bits (550), Expect = 6e-56
Identities = 173/749 (23%), Positives = 332/749 (44%), Gaps = 80/749 (10%)
Query: 42 WAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCT 101
W L+ +++L ++ +++ Y + G C++S C+ + + + + PCT
Sbjct: 24 WTPLEISLSVLVLLLTIIAVTMIALYATYDDGI--CKSSDCIKSAARLIQNMDATTEPCT 81
Query: 102 DFFSFACGRAKETNNSFQELATK--NKNRLRRILEV-------QNSWHPGSGEEKAFQFY 152
DFF +ACG + N E +++ N + LR LEV + +KA Y
Sbjct: 82 DFFKYACGGWLK-RNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALY 140
Query: 153 NSCMDTLAIEAAGTGPLRQVIEELGGWRIS---------GKWTSLNFNRTLRLLMSQYGH 203
SC++ AI++ G PL +++ ++ GW ++ WT+ + + L S+YG
Sbjct: 141 RSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA---EKAIAQLNSKYGK 197
Query: 204 FPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQE-QKIYAQIFREYLTYLNQLGTLLG 262
++G + VI IDQP +P + E IY + Y+ ++ + L+
Sbjct: 198 KVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIR 257
Query: 263 GDPSKVQEHSSLSISITSRLFQFLRPL-------EQRRAQGKLFQMVTIDQLKEM----- 310
+ + + L++ + +++ + + + E R L+ +T+ Q++
Sbjct: 258 QEERLPIDENQLALEM-NKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEI 316
Query: 311 -APAIDWLSCLQATFTPMSLSPS--QSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMIL 367
WL+ + +++S + + +VV+ EYL + ++ + + LQ+ M
Sbjct: 317 NGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARD---LQNLMSW 373
Query: 368 GLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFV 427
++ L +L ++E+R + L T + W +C E + L+V
Sbjct: 374 RFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-----WRRCANYVNGNMENAVGRLYV 428
Query: 428 REAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG------A 481
AF ++ L IR+ I L +L WM+ ET+ A++K ++ +G +
Sbjct: 429 EAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVS 488
Query: 482 SEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNA 541
++ L E Y + + ++++ ++ +++ ++ + + W VNA
Sbjct: 489 NDNKLNNEYLELNYKE----DEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNA 544
Query: 542 YYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDN 601
+YS + +VFPAG+LQPPFF ++N+G G ++ HE+ H F G D
Sbjct: 545 FYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDD---NGRNFNKDG 601
Query: 602 HAL-----------QEAHLCLKRHYAAF--PLPSRTSFNDSLTFLENAADVGGLAIALQA 648
+ +E C+ Y F L N T EN AD GGL A +A
Sbjct: 602 DLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRA 661
Query: 649 YSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDS-----HDTHSPPHLRVHG 703
Y + ++ E +LP LDL+ +Q+FF ++AQV C P+ + D HSP + R+ G
Sbjct: 662 YQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIG 721
Query: 704 PLSSTPAFARYFRCARGALLNPSSRCQLW 732
L ++ F+ F C + + +NP +C++W
Sbjct: 722 TLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|116256327 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 216 bits (550), Expect = 6e-56
Identities = 173/749 (23%), Positives = 332/749 (44%), Gaps = 80/749 (10%)
Query: 42 WAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCT 101
W L+ +++L ++ +++ Y + G C++S C+ + + + + PCT
Sbjct: 24 WTPLEISLSVLVLLLTIIAVTMIALYATYDDGI--CKSSDCIKSAARLIQNMDATTEPCT 81
Query: 102 DFFSFACGRAKETNNSFQELATK--NKNRLRRILEV-------QNSWHPGSGEEKAFQFY 152
DFF +ACG + N E +++ N + LR LEV + +KA Y
Sbjct: 82 DFFKYACGGWLK-RNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALY 140
Query: 153 NSCMDTLAIEAAGTGPLRQVIEELGGWRIS---------GKWTSLNFNRTLRLLMSQYGH 203
SC++ AI++ G PL +++ ++ GW ++ WT+ + + L S+YG
Sbjct: 141 RSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA---EKAIAQLNSKYGK 197
Query: 204 FPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQE-QKIYAQIFREYLTYLNQLGTLLG 262
++G + VI IDQP +P + E IY + Y+ ++ + L+
Sbjct: 198 KVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIR 257
Query: 263 GDPSKVQEHSSLSISITSRLFQFLRPL-------EQRRAQGKLFQMVTIDQLKEM----- 310
+ + + L++ + +++ + + + E R L+ +T+ Q++
Sbjct: 258 QEERLPIDENQLALEM-NKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEI 316
Query: 311 -APAIDWLSCLQATFTPMSLSPS--QSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMIL 367
WL+ + +++S + + +VV+ EYL + ++ + + LQ+ M
Sbjct: 317 NGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARD---LQNLMSW 373
Query: 368 GLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFV 427
++ L +L ++E+R + L T + W +C E + L+V
Sbjct: 374 RFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-----WRRCANYVNGNMENAVGRLYV 428
Query: 428 REAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG------A 481
AF ++ L IR+ I L +L WM+ ET+ A++K ++ +G +
Sbjct: 429 EAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVS 488
Query: 482 SEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNA 541
++ L E Y + + ++++ ++ +++ ++ + + W VNA
Sbjct: 489 NDNKLNNEYLELNYKE----DEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNA 544
Query: 542 YYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDN 601
+YS + +VFPAG+LQPPFF ++N+G G ++ HE+ H F G D
Sbjct: 545 FYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDD---NGRNFNKDG 601
Query: 602 HAL-----------QEAHLCLKRHYAAF--PLPSRTSFNDSLTFLENAADVGGLAIALQA 648
+ +E C+ Y F L N T EN AD GGL A +A
Sbjct: 602 DLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRA 661
Query: 649 YSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDS-----HDTHSPPHLRVHG 703
Y + ++ E +LP LDL+ +Q+FF ++AQV C P+ + D HSP + R+ G
Sbjct: 662 YQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIG 721
Query: 704 PLSSTPAFARYFRCARGALLNPSSRCQLW 732
L ++ F+ F C + + +NP +C++W
Sbjct: 722 TLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|116256329 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 216 bits (550), Expect = 6e-56
Identities = 173/749 (23%), Positives = 332/749 (44%), Gaps = 80/749 (10%)
Query: 42 WAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCT 101
W L+ +++L ++ +++ Y + G C++S C+ + + + + PCT
Sbjct: 24 WTPLEISLSVLVLLLTIIAVTMIALYATYDDGI--CKSSDCIKSAARLIQNMDATTEPCT 81
Query: 102 DFFSFACGRAKETNNSFQELATK--NKNRLRRILEV-------QNSWHPGSGEEKAFQFY 152
DFF +ACG + N E +++ N + LR LEV + +KA Y
Sbjct: 82 DFFKYACGGWLK-RNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALY 140
Query: 153 NSCMDTLAIEAAGTGPLRQVIEELGGWRIS---------GKWTSLNFNRTLRLLMSQYGH 203
SC++ AI++ G PL +++ ++ GW ++ WT+ + + L S+YG
Sbjct: 141 RSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA---EKAIAQLNSKYGK 197
Query: 204 FPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQE-QKIYAQIFREYLTYLNQLGTLLG 262
++G + VI IDQP +P + E IY + Y+ ++ + L+
Sbjct: 198 KVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIR 257
Query: 263 GDPSKVQEHSSLSISITSRLFQFLRPL-------EQRRAQGKLFQMVTIDQLKEM----- 310
+ + + L++ + +++ + + + E R L+ +T+ Q++
Sbjct: 258 QEERLPIDENQLALEM-NKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEI 316
Query: 311 -APAIDWLSCLQATFTPMSLSPS--QSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMIL 367
WL+ + +++S + + +VV+ EYL + ++ + + LQ+ M
Sbjct: 317 NGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARD---LQNLMSW 373
Query: 368 GLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFV 427
++ L +L ++E+R + L T + W +C E + L+V
Sbjct: 374 RFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-----WRRCANYVNGNMENAVGRLYV 428
Query: 428 REAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMG------A 481
AF ++ L IR+ I L +L WM+ ET+ A++K ++ +G +
Sbjct: 429 EAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVS 488
Query: 482 SEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNA 541
++ L E Y + + ++++ ++ +++ ++ + + W VNA
Sbjct: 489 NDNKLNNEYLELNYKE----DEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNA 544
Query: 542 YYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDN 601
+YS + +VFPAG+LQPPFF ++N+G G ++ HE+ H F G D
Sbjct: 545 FYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDD---NGRNFNKDG 601
Query: 602 HAL-----------QEAHLCLKRHYAAF--PLPSRTSFNDSLTFLENAADVGGLAIALQA 648
+ +E C+ Y F L N T EN AD GGL A +A
Sbjct: 602 DLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRA 661
Query: 649 YSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDS-----HDTHSPPHLRVHG 703
Y + ++ E +LP LDL+ +Q+FF ++AQV C P+ + D HSP + R+ G
Sbjct: 662 YQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIG 721
Query: 704 PLSSTPAFARYFRCARGALLNPSSRCQLW 732
L ++ F+ F C + + +NP +C++W
Sbjct: 722 TLQNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|90403592 phosphate-regulating neutral endopeptidase [Homo
sapiens]
Length = 749
Score = 209 bits (531), Expect = 1e-53
Identities = 175/706 (24%), Positives = 313/706 (44%), Gaps = 60/706 (8%)
Query: 77 CETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQE----------LATKNK 126
C C++ L+ N SV PC +FF FAC +NN E L
Sbjct: 54 CLKPECIEAAAAILSKVNLSVDPCDNFFRFACD-GWISNNPIPEDMPSYGVYPWLRHNVD 112
Query: 127 NRLRRILEVQNSWHPGSGE-EKAFQFYNSCMDTLAIEAAGTGPLRQVIEELG-GWRI--- 181
+L+ +LE S + +KA Y+SCM+ AIE A PL ++ W +
Sbjct: 113 LKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLES 172
Query: 182 ----SGKWTSLNFN--RTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLK 235
G W+ F+ +TL QY + F R Y+ P + + ++++DQ + ++
Sbjct: 173 NIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVR 232
Query: 236 QDQ-EQKIYAQIFREYL-TYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRR 293
+D + A+ +R+ L ++ LLG + S+ + + + ++ + + P E R
Sbjct: 233 EDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRT 292
Query: 294 AQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPM------SLSPSQSLVVHDVEYLKNMS 347
++ ++ + I +L M P DWL ++ +SPS+++VV +Y K++
Sbjct: 293 SEA-MYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLF 351
Query: 348 QLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRW 407
+++ +++ + ++++ +V + P L +FQ + S+ ++ T P+W
Sbjct: 352 RILGS---ERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTT-----LLPQW 403
Query: 408 MKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRL-RNLPWMNEETQN 466
KCV + + +FV F + +L +R A I L + WM+ T+
Sbjct: 404 DKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKR 463
Query: 467 MAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSS-FLQSVLSCVRSLRARIVQSFLQ 525
A++K + ++G E+ + ++ I+ + + +VL + L +
Sbjct: 464 KAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRK 523
Query: 526 PHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFF-HPGYPRAVNFGAAGSIMAHELL 584
P+ W +P VNA+YS S + + FPAG LQ PFF YPR++++GA G I+ HE
Sbjct: 524 AVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFT 583
Query: 585 HIFYQ---------LLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLEN 635
H F L P + ++ + ++ + + + T EN
Sbjct: 584 HGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGEN 643
Query: 636 AADVGGLAIALQAYSKRLL-RHHG--ETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHD 692
AD GGL A +AY K + R G E +LP + + Q+FF SYA V C P+ + +
Sbjct: 644 IADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAARE 703
Query: 693 -----THSPPHLRVHGPLSSTPAFARYFRCARGALLNPS-SRCQLW 732
HSPP RV+G +S+ F + F C + +N C+LW
Sbjct: 704 QVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 30.4 bits (67), Expect = 6.1
Identities = 23/93 (24%), Positives = 47/93 (50%), Gaps = 2/93 (2%)
Query: 268 VQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPM 327
VQ + +SITS++ + L+ + Q + V ++ K++A WL LQ +
Sbjct: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Query: 328 SLSPSQSLVVHDVEYLKNMSQLVE-EMLLKQRD 359
+ Q + H+++ + SQ E E++LK+++
Sbjct: 908 K-AHVQEVAQHNLKEASSASQFEELEIVLKEKE 939
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 30.4 bits (67), Expect = 6.1
Identities = 23/93 (24%), Positives = 47/93 (50%), Gaps = 2/93 (2%)
Query: 268 VQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPM 327
VQ + +SITS++ + L+ + Q + V ++ K++A WL LQ +
Sbjct: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Query: 328 SLSPSQSLVVHDVEYLKNMSQLVE-EMLLKQRD 359
+ Q + H+++ + SQ E E++LK+++
Sbjct: 908 K-AHVQEVAQHNLKEASSASQFEELEIVLKEKE 939
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 30.4 bits (67), Expect = 6.1
Identities = 23/93 (24%), Positives = 47/93 (50%), Gaps = 2/93 (2%)
Query: 268 VQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPM 327
VQ + +SITS++ + L+ + Q + V ++ K++A WL LQ +
Sbjct: 848 VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Query: 328 SLSPSQSLVVHDVEYLKNMSQLVE-EMLLKQRD 359
+ Q + H+++ + SQ E E++LK+++
Sbjct: 908 K-AHVQEVAQHNLKEASSASQFEELEIVLKEKE 939
>gi|45545435 COMM domain containing 2 [Homo sapiens]
Length = 199
Score = 30.0 bits (66), Expect = 8.0
Identities = 20/79 (25%), Positives = 34/79 (43%)
Query: 329 LSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKL 388
L+ S V H VE L + ++++ + DF S +LG L+ L + + R+++
Sbjct: 51 LNVSSDTVQHGVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLDNRKEI 110
Query: 389 SQKLRELTEQPPMPARPRW 407
L EL P W
Sbjct: 111 RTILSELAPSLPSYHNLEW 129
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,407,253
Number of Sequences: 37866
Number of extensions: 1455978
Number of successful extensions: 3838
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 3716
Number of HSP's gapped (non-prelim): 25
length of query: 732
length of database: 18,247,518
effective HSP length: 110
effective length of query: 622
effective length of database: 14,082,258
effective search space: 8759164476
effective search space used: 8759164476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.