BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4557599 glucose-6-phosphatase, catalytic subunit [Homo sapiens] (357 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4557599 glucose-6-phosphatase, catalytic subunit [Homo sapiens] 736 0.0 gi|10863975 islet-specific glucose-6-phosphatase-related protein... 373 e-103 gi|24308434 glucose-6-phosphatase catalytic subunit 3 [Homo sapi... 216 3e-56 gi|126273546 islet-specific glucose-6-phosphatase-related protei... 164 9e-41 gi|13540569 sphingosine-1-phosphate phosphatase 1 [Homo sapiens] 41 0.001 gi|23510289 sphingosine-1-phosphate phosphotase 2 [Homo sapiens] 37 0.035 gi|5174445 lanthionine synthetase C-like protein 1 [Homo sapiens] 30 2.5 gi|212274477 lanthionine synthetase C-like protein 1 [Homo sapiens] 30 2.5 gi|212274337 lanthionine synthetase C-like protein 1 [Homo sapiens] 30 2.5 gi|156104869 chloride channel 2 [Homo sapiens] 30 2.5 gi|51921275 olfactory receptor, family 52, subfamily M, member 1... 29 5.7 gi|42822887 Duffy blood group antigen isoform b [Homo sapiens] 28 9.7 gi|171846251 Duffy blood group antigen isoform a [Homo sapiens] 28 9.7 gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F... 28 9.7 gi|197304690 zinc finger, DHHC-type containing 4 [Homo sapiens] 28 9.7 gi|197304688 zinc finger, DHHC-type containing 4 [Homo sapiens] 28 9.7 gi|197304686 zinc finger, DHHC-type containing 4 [Homo sapiens] 28 9.7 gi|8922448 zinc finger, DHHC-type containing 4 [Homo sapiens] 28 9.7 >gi|4557599 glucose-6-phosphatase, catalytic subunit [Homo sapiens] Length = 357 Score = 736 bits (1899), Expect = 0.0 Identities = 357/357 (100%), Positives = 357/357 (100%) Query: 1 MEEGMNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIK 60 MEEGMNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIK Sbjct: 1 MEEGMNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIK 60 Query: 61 LLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHA 120 LLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHA Sbjct: 61 LLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHA 120 Query: 121 MGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQ 180 MGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQ Sbjct: 121 MGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQ 180 Query: 181 VVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEK 240 VVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEK Sbjct: 181 VVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEK 240 Query: 241 AQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIV 300 AQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIV Sbjct: 241 AQRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIV 300 Query: 301 ASLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKSL 357 ASLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKSL Sbjct: 301 ASLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKSL 357 >gi|10863975 islet-specific glucose-6-phosphatase-related protein isoform 1 [Homo sapiens] Length = 355 Score = 373 bits (958), Expect = e-103 Identities = 179/355 (50%), Positives = 237/355 (66%), Gaps = 4/355 (1%) Query: 5 MNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIKLLWV 64 M+ LH G+ +LQ +Y+ + +S + D RN F++ FP+ F + VG K++WV Sbjct: 1 MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV 60 Query: 65 AVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHAMGTA 124 AVIGDWLNL+FKWILFG RPYWWV +T Y N S P ++QFP TCETGPGSPSGHAMG + Sbjct: 61 AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS 120 Query: 125 GVYYVMVTSTLS---IFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQV 181 V+YVMVT+ LS K T R LW FW +Q++VC+SR+++A HFPHQV Sbjct: 121 CVWYVMVTAALSHTVCGMDKFSITLH-RLTWSFLWSVFWLIQISVCISRVFIATHFPHQV 179 Query: 182 VAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEKA 241 + GV+ G+ V E F H I ASL Y FLF FA+GFYLLL+ L +DLLW++ A Sbjct: 180 ILGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIA 239 Query: 242 QRWCEQPEWVHIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIVA 301 ++WC P+W+HIDTTPFA L++NLG LFGLG A+NS M+ SC+G + L FRL + Sbjct: 240 KKWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALT 299 Query: 302 SLVLLHVFDSLKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCLAQVLGQPHKKS 356 SL +L ++ L+ P+ E +FYVLSFCKSA +PL V+ IPY + ++ Q KKS Sbjct: 300 SLTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKS 354 >gi|24308434 glucose-6-phosphatase catalytic subunit 3 [Homo sapiens] Length = 346 Score = 216 bits (549), Expect = 3e-56 Identities = 120/334 (35%), Positives = 187/334 (55%), Gaps = 9/334 (2%) Query: 12 GIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIKLLWVAVIGDWL 71 GI LQ ++ ++ ++ + D + F FP ++ VGI +LW+++I +WL Sbjct: 8 GIVIAEALQNQLAWLENVWLWITFLGDPKILFLFYFPAAYYASRRVGIAVLWISLITEWL 67 Query: 72 NLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHAMGTAGVYYVMV 131 NL+FKW LFG RP+WWV ++ YYS + QFP +CETGPGSPSGH M T + ++ Sbjct: 68 NLIFKWFLFGDRPFWWVHESGYYSQAPAQ-VHQFPSSCETGPGSPSGHCMITGAALWPIM 126 Query: 132 TSTLSIFQGKIKPTYRFRCLNVILWLGFWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAV 191 T+ S ++ R R + V+ L + L V LSRI++ AHFPHQV+AG+++G AV Sbjct: 127 TALSS----QVATRARSRWVRVMPSLAYCTFLLAVGLSRIFILAHFPHQVLAGLITG-AV 181 Query: 192 TETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKGLGVDLLWTLEKAQRWCEQPEWV 251 L Y L L Y L LG+DL W++ A +WCE+PEW+ Sbjct: 182 LGWLMTPRVPMERELSFYGLTALALMLGTSLIYWTLFTLGLDLSWSISLAFKWCERPEWI 241 Query: 252 HIDTTPFASLLKNLGTLFGLGLALNSSMYRESCKGKLSKWLPFRLSSIVASLVLLHVFDS 311 H+D+ PFASL ++ G GLG+AL+S Y + + +L +++ +V ++ LL D Sbjct: 242 HVDSRPFASLSRDSGAALGLGIALHSPCYAQVRRAQLGNGQ--KIACLVLAMGLLGPLDW 299 Query: 312 LKPPSQVELVFYVLSFCKSAVVPLASVSVIPYCL 345 L P Q+ L FY+ +F K + P ++++P+ + Sbjct: 300 LGHPPQISL-FYIFNFLKYTLWPCLVLALVPWAV 332 >gi|126273546 islet-specific glucose-6-phosphatase-related protein isoform 2 [Homo sapiens] Length = 154 Score = 164 bits (416), Expect = 9e-41 Identities = 73/132 (55%), Positives = 94/132 (71%) Query: 5 MNVLHDFGIQSTHYLQVNYQDSQDWFILVSVIADLRNAFYVLFPIWFHLQEAVGIKLLWV 64 M+ LH G+ +LQ +Y+ + +S + D RN F++ FP+ F + VG K++WV Sbjct: 1 MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV 60 Query: 65 AVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVPLIKQFPVTCETGPGSPSGHAMGTA 124 AVIGDWLNL+FKWILFG RPYWWV +T Y N S P ++QFP TCETGPGSPSGHAMG + Sbjct: 61 AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS 120 Query: 125 GVYYVMVTSTLS 136 V+YVMVT+ LS Sbjct: 121 CVWYVMVTAALS 132 >gi|13540569 sphingosine-1-phosphate phosphatase 1 [Homo sapiens] Length = 441 Score = 41.2 bits (95), Expect = 0.001 Identities = 43/155 (27%), Positives = 66/155 (42%), Gaps = 25/155 (16%) Query: 43 FYVLF-PIW-FHLQEAVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNTSVP 100 FY+LF P W ++L VG +L+ + V+ +L K I+ RP S P Sbjct: 143 FYILFFPFWIWNLDPLVGRRLVVIWVLVMYLGQCTKDIIRWPRP------------ASPP 190 Query: 101 LIKQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWLGFW 160 ++K V + PS HAM + MV T +Q + + ++ + W Sbjct: 191 VVK-LEVFYNSEYSMPSTHAMSGTAIPISMVLLTYGRWQ--------YPLIYGLILIPCW 241 Query: 161 AVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVTETF 195 VCLSRIY+ H ++AG L I + F Sbjct: 242 CSL--VCLSRIYMGMHSILDIIAGFLYTILILAVF 274 >gi|23510289 sphingosine-1-phosphate phosphotase 2 [Homo sapiens] Length = 399 Score = 36.6 bits (83), Expect = 0.035 Identities = 37/149 (24%), Positives = 64/149 (42%), Gaps = 25/149 (16%) Query: 40 RNAFYVLFPIWFH--LQEAVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVLDTDYYSNT 97 + FY+ F + H + + +L+ + V+ ++ V K +L RP Sbjct: 98 QEVFYITFLPFTHWNIDPYLSRRLIIIWVLVMYIGQVAKDVLKWPRP------------- 144 Query: 98 SVPLIKQFPVTCETGPGSPSGHAMGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWL 157 S P + + G PS HAM + + ++ ST+ +Q Y F L +++ + Sbjct: 145 SSPPVVKLEKRLIAEYGMPSTHAMAATAIAFTLLISTMDRYQ------YPF-VLGLVMAV 197 Query: 158 GFWAVQLNVCLSRIYLAAHFPHQVVAGVL 186 F + VCLSR+Y H V+ GVL Sbjct: 198 VFSTL---VCLSRLYTGMHTVLDVLGGVL 223 >gi|5174445 lanthionine synthetase C-like protein 1 [Homo sapiens] Length = 399 Score = 30.4 bits (67), Expect = 2.5 Identities = 14/37 (37%), Positives = 22/37 (59%), Gaps = 4/37 (10%) Query: 118 GHAMGTAGVYYVMVTSTLSIFQGK----IKPTYRFRC 150 G A G AG+YY ++ +L + QGK +KP+ + C Sbjct: 216 GAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVC 252 >gi|212274477 lanthionine synthetase C-like protein 1 [Homo sapiens] Length = 399 Score = 30.4 bits (67), Expect = 2.5 Identities = 14/37 (37%), Positives = 22/37 (59%), Gaps = 4/37 (10%) Query: 118 GHAMGTAGVYYVMVTSTLSIFQGK----IKPTYRFRC 150 G A G AG+YY ++ +L + QGK +KP+ + C Sbjct: 216 GAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVC 252 >gi|212274337 lanthionine synthetase C-like protein 1 [Homo sapiens] Length = 399 Score = 30.4 bits (67), Expect = 2.5 Identities = 14/37 (37%), Positives = 22/37 (59%), Gaps = 4/37 (10%) Query: 118 GHAMGTAGVYYVMVTSTLSIFQGK----IKPTYRFRC 150 G A G AG+YY ++ +L + QGK +KP+ + C Sbjct: 216 GAAHGLAGIYYYLMQPSLQVSQGKLHSLVKPSVDYVC 252 >gi|156104869 chloride channel 2 [Homo sapiens] Length = 898 Score = 30.4 bits (67), Expect = 2.5 Identities = 30/124 (24%), Positives = 48/124 (38%), Gaps = 21/124 (16%) Query: 101 LIKQFPVTCETGPGSPSGHA---MGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNVILWL 157 + K +TC G G P G + A + +++ LS+F G Y N + Sbjct: 186 IAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGG----IYENESRNTEMLA 241 Query: 158 GFWAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLF 217 AV + C + + GVL I VT TF + + + + +F TF F Sbjct: 242 AACAVGVGCCFAA----------PIGGVLFSIEVTSTFFAVRNYW----RGFFAATFSAF 287 Query: 218 SFAI 221 F + Sbjct: 288 IFRV 291 >gi|51921275 olfactory receptor, family 52, subfamily M, member 1 [Homo sapiens] Length = 317 Score = 29.3 bits (64), Expect = 5.7 Identities = 32/131 (24%), Positives = 53/131 (40%), Gaps = 23/131 (17%) Query: 116 PSGHAMGTAGVYYVMVTSTLSIFQGKIKPTYRFRCLNV----------------ILWLGF 159 P G A V V + + + I + +P Y F C+ I W G Sbjct: 32 PFGSMYLVAVVGNVTILAVVKIERSLHQPMYFFLCMLAAIDLVLSTSTIPKLLGIFWFGA 91 Query: 160 WAVQLNVCLSRIYLAAHFPHQVVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSF 219 + L+ CL +++L F A V SGI + F +I N L+ ++T+ + Sbjct: 92 CDIGLDACLGQMFLIHCF-----ATVESGIFLAMAFDRYVAICN-PLRHSMVLTYTVVG- 144 Query: 220 AIGFYLLLKGL 230 +G LL+G+ Sbjct: 145 RLGLVSLLRGV 155 >gi|42822887 Duffy blood group antigen isoform b [Homo sapiens] Length = 336 Score = 28.5 bits (62), Expect = 9.7 Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 11/65 (16%) Query: 42 AFYVLFPIWFHLQEAVGIKLLWVAVIGDWLNLVFKWILFGQRPYWW----VLDTDYYSNT 97 A +VL P+ L A G+K G W+N+++ W +F WW VL D+ + Sbjct: 216 AIFVLLPLG--LFGAKGLKKALGMGPGPWMNILWAWFIF-----WWPHGVVLGLDFLVRS 268 Query: 98 SVPLI 102 + L+ Sbjct: 269 KLLLL 273 >gi|171846251 Duffy blood group antigen isoform a [Homo sapiens] Length = 338 Score = 28.5 bits (62), Expect = 9.7 Identities = 19/65 (29%), Positives = 31/65 (47%), Gaps = 11/65 (16%) Query: 42 AFYVLFPIWFHLQEAVGIKLLWVAVIGDWLNLVFKWILFGQRPYWW----VLDTDYYSNT 97 A +VL P+ L A G+K G W+N+++ W +F WW VL D+ + Sbjct: 218 AIFVLLPLG--LFGAKGLKKALGMGPGPWMNILWAWFIF-----WWPHGVVLGLDFLVRS 270 Query: 98 SVPLI 102 + L+ Sbjct: 271 KLLLL 275 >gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F subunit [Homo sapiens] Length = 1977 Score = 28.5 bits (62), Expect = 9.7 Identities = 25/67 (37%), Positives = 32/67 (47%), Gaps = 2/67 (2%) Query: 177 FPHQVVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFF-LFSFAIGFYLLLKGLGV-DL 234 F +V G + IAVTE + H ++ ITFF LF LL KG G+ L Sbjct: 1257 FDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTL 1316 Query: 235 LWTLEKA 241 LWT K+ Sbjct: 1317 LWTFIKS 1323 >gi|197304690 zinc finger, DHHC-type containing 4 [Homo sapiens] Length = 344 Score = 28.5 bits (62), Expect = 9.7 Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 1/77 (1%) Query: 179 HQVVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKG-LGVDLLWT 237 H VV L + H+H + L +Y +TF F +GF ++L LG LL+ Sbjct: 218 HLVVMSDLYQETYIDDLGHLHVMDTVFLIQYLFLTFPRIVFMLGFVVVLSFLLGGYLLFV 277 Query: 238 LEKAQRWCEQPEWVHID 254 L A EW D Sbjct: 278 LYLAATNQTTNEWYRGD 294 >gi|197304688 zinc finger, DHHC-type containing 4 [Homo sapiens] Length = 344 Score = 28.5 bits (62), Expect = 9.7 Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 1/77 (1%) Query: 179 HQVVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKG-LGVDLLWT 237 H VV L + H+H + L +Y +TF F +GF ++L LG LL+ Sbjct: 218 HLVVMSDLYQETYIDDLGHLHVMDTVFLIQYLFLTFPRIVFMLGFVVVLSFLLGGYLLFV 277 Query: 238 LEKAQRWCEQPEWVHID 254 L A EW D Sbjct: 278 LYLAATNQTTNEWYRGD 294 >gi|197304686 zinc finger, DHHC-type containing 4 [Homo sapiens] Length = 344 Score = 28.5 bits (62), Expect = 9.7 Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 1/77 (1%) Query: 179 HQVVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKG-LGVDLLWT 237 H VV L + H+H + L +Y +TF F +GF ++L LG LL+ Sbjct: 218 HLVVMSDLYQETYIDDLGHLHVMDTVFLIQYLFLTFPRIVFMLGFVVVLSFLLGGYLLFV 277 Query: 238 LEKAQRWCEQPEWVHID 254 L A EW D Sbjct: 278 LYLAATNQTTNEWYRGD 294 >gi|8922448 zinc finger, DHHC-type containing 4 [Homo sapiens] Length = 344 Score = 28.5 bits (62), Expect = 9.7 Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 1/77 (1%) Query: 179 HQVVAGVLSGIAVTETFSHIHSIYNASLKKYFLITFFLFSFAIGFYLLLKG-LGVDLLWT 237 H VV L + H+H + L +Y +TF F +GF ++L LG LL+ Sbjct: 218 HLVVMSDLYQETYIDDLGHLHVMDTVFLIQYLFLTFPRIVFMLGFVVVLSFLLGGYLLFV 277 Query: 238 LEKAQRWCEQPEWVHID 254 L A EW D Sbjct: 278 LYLAATNQTTNEWYRGD 294 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.327 0.141 0.460 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,263,968 Number of Sequences: 37866 Number of extensions: 548956 Number of successful extensions: 1471 Number of sequences better than 10.0: 18 Number of HSP's better than 10.0 without gapping: 8 Number of HSP's successfully gapped in prelim test: 10 Number of HSP's that attempted gapping in prelim test: 1457 Number of HSP's gapped (non-prelim): 18 length of query: 357 length of database: 18,247,518 effective HSP length: 103 effective length of query: 254 effective length of database: 14,347,320 effective search space: 3644219280 effective search space used: 3644219280 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.