Search of human proteins with 4557255

Search of human proteins with 4557255

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557255 adenylate cyclase 7 [Homo sapiens]
         (1080 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557255 adenylate cyclase 7 [Homo sapiens]                        2190   0.0  
gi|115387102 adenylate cyclase 2 [Homo sapiens]                      1123   0.0  
gi|24497587 adenylate cyclase 4 [Homo sapiens]                       1016   0.0  
gi|34486092 adenylate cyclase 5 [Homo sapiens]                        644   0.0  
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]              639   0.0  
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]              638   0.0  
gi|4557257 adenylate cyclase 8 [Homo sapiens]                         595   e-170
gi|31083193 adenylate cyclase 1 [Homo sapiens]                        592   e-169
gi|148536830 adenylate cyclase 3 [Homo sapiens]                       563   e-160
gi|50959205 adenylate cyclase 9 [Homo sapiens]                        202   2e-51
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]            118   3e-26
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho...   118   3e-26
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   118   3e-26
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   118   3e-26
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom...   118   3e-26
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   118   3e-26
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho...   117   4e-26
gi|134152694 guanylate cyclase 2F [Homo sapiens]                      113   8e-25
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]    113   1e-24
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]       112   2e-24
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom...   110   9e-24
gi|222080083 guanylate cyclase 2C [Homo sapiens]                      103   9e-22
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]        102   2e-21
gi|209976994 adenylate cyclase 10 [Homo sapiens]                       39   0.035
gi|157388953 G protein-coupled receptor 172B [Homo sapiens]            34   0.65 
gi|157388951 G protein-coupled receptor 172B [Homo sapiens]            34   0.65 
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     34   0.65 
gi|239756380 PREDICTED: hypothetical protein [Homo sapiens]            33   1.1  
gi|239750901 PREDICTED: hypothetical protein XP_002347602 [Homo ...    33   1.1  
gi|239745293 PREDICTED: hypothetical protein XP_002343426 [Homo ...    33   1.1  

>gi|4557255 adenylate cyclase 7 [Homo sapiens]
          Length = 1080

 Score = 2190 bits (5675), Expect = 0.0
 Identities = 1080/1080 (100%), Positives = 1080/1080 (100%)

Query: 1    MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS 60
            MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS
Sbjct: 1    MPAKGRYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPS 60

Query: 61   RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA 120
            RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA
Sbjct: 61   RHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAA 120

Query: 121  CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL 180
            CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL
Sbjct: 121  CAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQL 180

Query: 181  LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH 240
            LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH
Sbjct: 181  LANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAH 240

Query: 241  ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL 300
            ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL
Sbjct: 241  ISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL 300

Query: 301  VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ 360
            VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ
Sbjct: 301  VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQ 360

Query: 361  VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT 420
            VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT
Sbjct: 361  VREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT 420

Query: 421  LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA 480
            LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA
Sbjct: 421  LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA 480

Query: 481  SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS 540
            SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS
Sbjct: 481  SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRS 540

Query: 541  EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA 600
            EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA
Sbjct: 541  EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACA 600

Query: 601  SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER 660
            SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER
Sbjct: 601  SLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISER 660

Query: 661  VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP 720
            VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP
Sbjct: 661  VETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP 720

Query: 721  YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP 780
            YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP
Sbjct: 721  YYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKP 780

Query: 781  NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET 840
            NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET
Sbjct: 781  NGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFET 840

Query: 841  MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE 900
            MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE
Sbjct: 841  MENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKE 900

Query: 901  GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH 960
            GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH
Sbjct: 901  GLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAH 960

Query: 961  IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS 1020
            IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS
Sbjct: 961  IGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVAS 1020

Query: 1021 RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN 1080
            RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN
Sbjct: 1021 RMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTDTAKFQGLGLN 1080


>gi|115387102 adenylate cyclase 2 [Homo sapiens]
          Length = 1091

 Score = 1123 bits (2904), Expect = 0.0
 Identities = 597/1091 (54%), Positives = 760/1091 (69%), Gaps = 41/1091 (3%)

Query: 6    RYFLNEGEEGP--------DQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQG 57
            RY  +  EE           +D LYE Y   SQ  PL++ LLL+   +C+AL+ + F+ G
Sbjct: 10   RYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALG 69

Query: 58   -DPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAW 116
             +   H A L      LA+F A+ +L+ +E + ++ LR  +L+ W CLVA+GY+  F  +
Sbjct: 70   LEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYL--FMCF 127

Query: 117  TKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRV 176
                  W+QV FFLFI+FVVYT+LPF+MR A+    ++++SH +VL   +         +
Sbjct: 128  GGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHL 187

Query: 177  GLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSV 236
              Q+LAN +IF+CGNL GA+HKH M+ A +  +  T  CI+ R KL  EKRQQE LLLS+
Sbjct: 188  VWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSL 247

Query: 237  LPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCS 296
            LPAHI+M MK  II+RL+     +    NNFH+LYVKRH NVSILYADIVGFT+LASDCS
Sbjct: 248  LPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCS 307

Query: 297  PKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQ 356
            P ELV +LNELFGKFDQIAK NECMRIKILGDCYYCVSGLP+SLP HA+NCVKMGLDMC+
Sbjct: 308  PGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCE 367

Query: 357  AIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHI 416
            AIK+VR+ATGVDINMRVG+HSGNVLCGVIGL+KWQYDVWSHDV+LAN MEA GVPGRVHI
Sbjct: 368  AIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHI 427

Query: 417  TEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDA-A 475
            +  TL+HL+ AY+VE+G G  RDPYLK+  ++TY VI+P+ ++  P  QHL RP+     
Sbjct: 428  SSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSP--QHLFRPRHTLDG 485

Query: 476  LKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMS 535
             KMRASVRMTRYLESWGAA+PFAHL+HR+S+++    +     P        RT  R+ S
Sbjct: 486  AKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL-RTKS 544

Query: 536  PKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARH 595
             K R E++  ++ M+ AI+G+++ +    KS+D      +F  K  E+EYR   +P  ++
Sbjct: 545  QKKRFEEE-LNERMIQAIDGINAQKQWL-KSEDIQRISLLFYNKVLEKEYRATALPAFKY 602

Query: 596  DFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRC----CPAR 651
               CA LIF CI +V +L++P+T+ LG+SFG    +L  +L +CFA +  +C     P  
Sbjct: 603  YVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLL 662

Query: 652  GTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPEL-PVGNETGL-LAAS 709
              L   S  +  +P  R++L ++T   +L +A+ N+  +      + P  N T    +AS
Sbjct: 663  MWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSAS 722

Query: 710  SKTRALCEP-----LPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPC 764
            +   A+        LPY+  SC+LG I+CSVFLR++ E K++++ VALV Y  +      
Sbjct: 723  NNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTIL----- 777

Query: 765  WQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLD 824
                     LG+ ++      G     WKDLKTM +  L +F+ITLL L RQ +YYCRLD
Sbjct: 778  --LHTHAHVLGDYSQVLFERPGI----WKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLD 831

Query: 825  CLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKL-NEDWYHQSYDCVCVMFA 883
             LWK KFKKE EE ETMEN+NR+LLENVLPAHVA HF+   L NE+ YHQSYDCVCVMFA
Sbjct: 832  FLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFA 891

Query: 884  SVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGL 943
            S+PDFK FYTE DVNKEGLECLRLLNEIIADFD+LL KPKFSGVEKIKTIGSTYMAA GL
Sbjct: 892  SIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGL 951

Query: 944  S-VASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVI 1002
            S V S   +QE ERQ+ HIG MVEF+ AL+ KLD IN+HSFN F+LRVGINHGPVIAGVI
Sbjct: 952  SAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVI 1011

Query: 1003 GARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGEL 1062
            GA+KPQYDIWGNTVNVASRM+STG L KIQVTEET  +LQ LGY+C CRG+INVKGKG+L
Sbjct: 1012 GAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDL 1071

Query: 1063 RTYFVCTDTAK 1073
            +TYFV T+ ++
Sbjct: 1072 KTYFVNTEMSR 1082


>gi|24497587 adenylate cyclase 4 [Homo sapiens]
          Length = 1077

 Score = 1016 bits (2626), Expect = 0.0
 Identities = 572/1083 (52%), Positives = 713/1083 (65%), Gaps = 50/1083 (4%)

Query: 16   PDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQG-----DPSRHQAILGMAF 70
            P +D  YE Y   SQ  PLLL LL +   A  AL+ +A++ G     DPS     L    
Sbjct: 11   PSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPS----FLTTVL 66

Query: 71   LVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFL 130
              L  F+ L  L   E  L+RW R L+ L W  L+ALG+  +F     +A  W+QV +FL
Sbjct: 67   CALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSA--WDQVSYFL 124

Query: 131  FIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGL--QLLANAVIFL 188
            F++F  Y +LP  MR A   G  S+ SHLLVLG  +G    P  R  L  QL ANAV+FL
Sbjct: 125  FVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLG--PQPDSRPALLPQLAANAVLFL 182

Query: 189  CGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLA 248
            CGN+ G +HK  M+ A R  F   +  +  RR+L  EK+ QE+LLLS+LPA+++  MK  
Sbjct: 183  CGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAE 242

Query: 249  IIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELF 308
            I+ RL+     R    NNFHSLYVKRHQ VS+LYADIVGFT+LAS+CSPKELV++LNELF
Sbjct: 243  IMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELF 302

Query: 309  GKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVD 368
            GKFDQIAK +ECMRIKILGDCYYCVSGLP+SLP HA NCV+MGLDMC+AI+++R ATGVD
Sbjct: 303  GKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVD 362

Query: 369  INMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAY 428
            INMRVG+HSG+VLCGVIGL+KWQYDVWSHDV+LAN MEA GVPGRVHIT ATL  L  AY
Sbjct: 363  INMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAY 422

Query: 429  EVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYL 488
             VED   + RDPYL+E+   TYLVIDPR+++                LKMR S+ MTRYL
Sbjct: 423  AVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYL 482

Query: 489  ESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSED-DSYDD 547
            ESWGAA+PFAHL+H +S  S  T +P         Q    + DRS +P+G  ++ D+ D 
Sbjct: 483  ESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQ---WSLDRSRTPRGLDDELDTGDA 539

Query: 548  EMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCI 607
            +    IE L+S +    +S DF      F EK  E+EYRL+ IP  ++  AC  L+F+  
Sbjct: 540  KFFQVIEQLNSQKQ-WKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSN 598

Query: 608  LLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGT-----LCTISERVE 662
             ++ +L+  R  AL +++ +   +  L+L +CF+    RC   +G      L  +S  V 
Sbjct: 599  FIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCV-LKGPKMLHWLPALSGLVA 657

Query: 663  TQPLLRLTLAVLTIGSLLTVAIINLPLM------PFQVPELP--VGNETGLLAASSKTRA 714
            T+P LR+ L   TI  +  +AI +L         PFQ P +   + N +  L  S    +
Sbjct: 658  TRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLIS 717

Query: 715  LCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDC--CGQ 772
                +PY    C LGF++CS+FL MS E K++LL + L A   LF  S  W  +C     
Sbjct: 718  ----VPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRL 773

Query: 773  GLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFK 832
             LG L    G          K+ K M      +F+ TLL L+RQ +YYCRLD LWKKK +
Sbjct: 774  YLGPLDSRPGVL--------KEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLR 825

Query: 833  KEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKLNEDWYHQSYDCVCVMFASVPDFKVF 891
            +E EE ETMEN+ RLLLENVLPAHVA  FIG ++ NED YHQSY+CVCV+FASVPDFK F
Sbjct: 826  QEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEF 885

Query: 892  YTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHE- 950
            Y+E ++N EGLECLRLLNEIIADFDELL KPKFSGVEKIKTIGSTYMAA GL+  SG + 
Sbjct: 886  YSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDA 945

Query: 951  NQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYD 1010
             Q+ ER  +H+G MVEF++AL SKLD IN+HSFN+FRLRVG+NHGPV+AGVIGA+KPQYD
Sbjct: 946  QQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYD 1005

Query: 1011 IWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTD 1070
            IWGNTVNVASRMESTG LGKIQVTEET   LQ LGY+C  RG+I VKGKG+L TYF+ TD
Sbjct: 1006 IWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTD 1065

Query: 1071 TAK 1073
              +
Sbjct: 1066 LTR 1068


>gi|34486092 adenylate cyclase 5 [Homo sapiens]
          Length = 1261

 Score =  644 bits (1662), Expect = 0.0
 Identities = 413/1088 (37%), Positives = 600/1088 (55%), Gaps = 99/1088 (9%)

Query: 19   DALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAA 78
            + LY++Y        L +   L+A    V L+++AF    P      L     VLA  AA
Sbjct: 227  ERLYQRYFFRLNQSSLTM---LMAVLVLVCLVMLAFHAARPPLQLPYLA----VLA--AA 277

Query: 79   LSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDA----WTKAACAWEQVPFFLFIVF 134
            + V++ +  L  R       +  AC   +  VL          +   A E + + +F ++
Sbjct: 278  VGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIY 337

Query: 135  VVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGL--QLLANAVIFLCGNL 192
             +YTLLP  MR AV  G + +A HL +         T +    L  QL++N +IF C N+
Sbjct: 338  TIYTLLPVRMRAAVLSGVLLSALHLAI------ALRTNAQDQFLLKQLVSNVLIFSCTNI 391

Query: 193  TGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIER 252
             G    +  + + R  F  T +CIQ R   + E +QQE LLLSVLP H++M MK  I  +
Sbjct: 392  VGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK 451

Query: 253  LKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFD 312
             +         D  FH +Y+++H NVSIL+ADI GFT LAS C+ +ELV+ LNELF +FD
Sbjct: 452  QE---------DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFD 502

Query: 313  QIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMR 372
            ++A  N C+RIKILGDCYYCVSGLP +   HA  CV+MG+DM +AI  VRE TGV++NMR
Sbjct: 503  KLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMR 562

Query: 373  VGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVED 432
            VGIHSG V CGV+GLRKWQ+DVWS+DV+LAN MEA G  GR+HIT+ATL +L+  YEVE 
Sbjct: 563  VGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEP 622

Query: 433  GHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYL---- 488
            G G +R+ YLKE +I T+L++  R  Q         + K + A+  + + + T  +    
Sbjct: 623  GCGGERNAYLKEHSIETFLIL--RCTQ---------KRKEEKAMIAKMNRQRTNSIGHNP 671

Query: 489  ESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDE 548
              WGA RPF +            H+   +  K + +     P    + +  + +D  D+ 
Sbjct: 672  PHWGAERPFYN------------HLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEF 719

Query: 549  MLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCIL 608
            +  AI+  S  R    +S+    F   F E   E++Y      R     ACASL+F+ I 
Sbjct: 720  LGRAIDARSIDR---LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFIC 776

Query: 609  LVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLR 668
             V + ++P +  + +SF L  C L L L +  +  +S        L T+S ++    +  
Sbjct: 777  FVQITIVPHSIFM-LSFYL-TCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNS 834

Query: 669  LTLAVLTIGSLLTVAIINL---------------------PLMPFQVPELPV----GNET 703
              + V TI  +   A +N+                      +    V E  V    G+E 
Sbjct: 835  TLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQ 894

Query: 704  GLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSP 763
            G   +       C    Y+T S +L  +ACSVFL++S   K+VL+    + Y+++  +  
Sbjct: 895  GFCGSPWPN---CNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPG 951

Query: 764  CWQWDCCG--QGLGNLTKPNGTTSGTPSCSWK-DLKTMTNFYLVLFYITLLTLSRQIDYY 820
               +D          +   N  TS  P  + K  LK +T   + +F + L   ++Q++  
Sbjct: 952  VTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVEST 1011

Query: 821  CRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKLNEDWYHQSYDCVC 879
             RLD LWK +  +E EE E ++  NR LL N+LP  VAAHF+  ++ N++ Y+QS +CV 
Sbjct: 1012 ARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVA 1071

Query: 880  VMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMA 939
            VMFAS+ +F  FY E + N EG+ECLRLLNEIIADFDE++ + +F  +EKIKTIGSTYMA
Sbjct: 1072 VMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMA 1131

Query: 940  AAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIA 999
            A+GL+ ++  +  +      HI  + +F++ LM ++  IN HSFN+F++++G+N GPV+A
Sbjct: 1132 ASGLNDSTYDKVGK-----THIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVA 1186

Query: 1000 GVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGK 1059
            GVIGARKPQYDIWGNTVNVASRM+STG   +IQVT +   +L    Y  ECRG++ VKGK
Sbjct: 1187 GVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGK 1246

Query: 1060 GELRTYFV 1067
            GE+ TYF+
Sbjct: 1247 GEMMTYFL 1254


>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
          Length = 1168

 Score =  639 bits (1648), Expect = 0.0
 Identities = 411/1079 (38%), Positives = 592/1079 (54%), Gaps = 83/1079 (7%)

Query: 19   DALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAA 78
            + LY++Y        L L   L+A    +  +++AF         A + +     A+F  
Sbjct: 137  ERLYQRYFFQMNQSSLTL---LMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVG 193

Query: 79   LSVLMYVECLLR--RWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVV 136
            L V+       +   W+ +  +L     V +G  L  D  + +A  W  V    F V++ 
Sbjct: 194  LMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPV----FFVYIA 249

Query: 137  YTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAF 196
            YTLLP  MR AV  G   +  HL++   L  G       +  QL AN ++FLC N+ G  
Sbjct: 250  YTLLPIRMRAAVLSGLGLSTLHLILAWQLNRG----DAFLWKQLGANVLLFLCTNVIGIC 305

Query: 197  HKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEH 256
              +  + + R  F  T   IQ R  L+ E RQQE LLLSVLP H++M MK  I  + +  
Sbjct: 306  THYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE-- 363

Query: 257  GDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAK 316
                   D  FH +Y+++H NVSIL+ADI GFT LAS C+ +ELV+ LNELF +FD++A 
Sbjct: 364  -------DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAA 416

Query: 317  ANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIH 376
             N C+RIKILGDCYYCVSGLP +   HA  CV+MG+DM +AI  VRE TGV++NMRVGIH
Sbjct: 417  ENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIH 476

Query: 377  SGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQ 436
            SG V CGV+GLRKWQ+DVWS+DV+LAN MEA G  GR+HIT ATL++L+  YEVE G G 
Sbjct: 477  SGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGG 536

Query: 437  QRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARP 496
            +R+ YLKE +I T+L++    ++    +         A L+   +  M   +  W   R 
Sbjct: 537  ERNAYLKEQHIETFLILGASQKRKEEKAML-------AKLQRTRANSMEGLMPRWVPDRA 589

Query: 497  FAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGL 556
            F+    ++S +  +  + +  +       +R T D +++P     +D  D+ +  AI+  
Sbjct: 590  FSRT--KDSKAFRQMGIDDSSKD------NRGTQD-ALNP-----EDEVDEFLSRAIDAR 635

Query: 557  SSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMP 616
            S  +    + D    F   F  +  E++Y     PR     ACA L+F  I  + +L+ P
Sbjct: 636  SIDQ---LRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFP 692

Query: 617  R-TAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLT 675
              T  LG+   +   +L  VL +C         P    L  +S  +         + + +
Sbjct: 693  HSTLMLGIYASIFLLLLITVL-ICAVYSCGSLFPK--ALQRLSRSIVRSRAHSTAVGIFS 749

Query: 676  IGSLLTVAIIN----------------LPLMPFQVPEL---PVGNETGLLAASSK-TRAL 715
            +  + T AI N                L L P  +       +    GL A   + T   
Sbjct: 750  VLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPT 809

Query: 716  CEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSP----CWQWDCCG 771
            C    Y+  + +L  +A SVFL +S   K+ ++ V  + YLVL  L P       +D   
Sbjct: 810  CSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLL- 868

Query: 772  QGLGNLTKPNGTTSG--TPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKK 829
             G+  L   N T  G   P+     LK MT   L++F + L   ++Q++   RLD LWK 
Sbjct: 869  LGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKL 928

Query: 830  KFKKEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKLNEDWYHQSYDCVCVMFASVPDF 888
            +   E EE E ++  NR LL N+LP  VAAHF+  ++ N++ Y+QS +CV VMFAS+ +F
Sbjct: 929  QATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF 988

Query: 889  KVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASG 948
              FY E + N EG+ECLRLLNEIIADFDE++ + +F  +EKIKTIGSTYMAA+GL+ AS 
Sbjct: 989  SEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN-AST 1047

Query: 949  HENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQ 1008
            ++    +   +HI  + ++++ LM ++  IN HSFN+F++++G+N GPV+AGVIGARKPQ
Sbjct: 1048 YD----QVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQ 1103

Query: 1009 YDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFV 1067
            YDIWGNTVNV+SRM+STG   +IQVT +   +L   GY  ECRG++ VKGKGE+ TYF+
Sbjct: 1104 YDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFL 1162


>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
          Length = 1115

 Score =  638 bits (1646), Expect = 0.0
 Identities = 405/1060 (38%), Positives = 588/1060 (55%), Gaps = 98/1060 (9%)

Query: 19   DALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAA 78
            + LY++Y        L L   L+A    +  +++AF         A + +     A+F  
Sbjct: 137  ERLYQRYFFQMNQSSLTL---LMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVG 193

Query: 79   LSVLMYVECLLR--RWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVV 136
            L V+       +   W+ +  +L     V +G  L  D  + +A  W  V    F V++ 
Sbjct: 194  LMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPV----FFVYIA 249

Query: 137  YTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAF 196
            YTLLP  MR AV  G   +  HL++   L  G       +  QL AN ++FLC N+ G  
Sbjct: 250  YTLLPIRMRAAVLSGLGLSTLHLILAWQLNRG----DAFLWKQLGANVLLFLCTNVIGIC 305

Query: 197  HKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEH 256
              +  + + R  F  T   IQ R  L+ E RQQE LLLSVLP H++M MK  I  + +  
Sbjct: 306  THYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE-- 363

Query: 257  GDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAK 316
                   D  FH +Y+++H NVSIL+ADI GFT LAS C+ +ELV+ LNELF +FD++A 
Sbjct: 364  -------DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAA 416

Query: 317  ANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIH 376
             N C+RIKILGDCYYCVSGLP +   HA  CV+MG+DM +AI  VRE TGV++NMRVGIH
Sbjct: 417  ENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIH 476

Query: 377  SGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQ 436
            SG V CGV+GLRKWQ+DVWS+DV+LAN MEA G  GR+HIT ATL++L+  YEVE G G 
Sbjct: 477  SGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGG 536

Query: 437  QRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARP 496
            +R+ YLKE +I T+L++    ++    +         A L+   +  M   +  W   R 
Sbjct: 537  ERNAYLKEQHIETFLILGASQKRKEEKAML-------AKLQRTRANSMEGLMPRWVPDRA 589

Query: 497  FAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGL 556
            F+    ++S +  +  + +  +       +R T D +++P     +D  D+ +  AI+  
Sbjct: 590  FSRT--KDSKAFRQMGIDDSSKD------NRGTQD-ALNP-----EDEVDEFLSRAIDAR 635

Query: 557  SSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMP 616
            S  +    + D    F   F  +  E++Y     PR     ACA L+F  I  + +L+ P
Sbjct: 636  SIDQ---LRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFP 692

Query: 617  RTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLTI 676
             +  +    G+ A +  L+L                             +  L  AV + 
Sbjct: 693  HSTLM---LGIYASIFLLLL-----------------------------ITVLICAVYSC 720

Query: 677  GSLLTVAI--INLPLMPFQVPELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACS 734
            GSL   A+  ++  ++  +     VG  + LL  +S    +     Y+  + +L  +A S
Sbjct: 721  GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM-----YFIGNMLLSLLASS 775

Query: 735  VFLRMSLEPKVVLLTVALVAYLVLFNLSP----CWQWDCCGQGLGNLTKPNGTTSG--TP 788
            VFL +S   K+ ++ V  + YLVL  L P       +D    G+  L   N T  G   P
Sbjct: 776  VFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLL-LGVHGLASSNETFDGLDCP 834

Query: 789  SCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLL 848
            +     LK MT   L++F + L   ++Q++   RLD LWK +   E EE E ++  NR L
Sbjct: 835  AAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRL 894

Query: 849  LENVLPAHVAAHFIG-DKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRL 907
            L N+LP  VAAHF+  ++ N++ Y+QS +CV VMFAS+ +F  FY E + N EG+ECLRL
Sbjct: 895  LHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRL 954

Query: 908  LNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEF 967
            LNEIIADFDE++ + +F  +EKIKTIGSTYMAA+GL+ AS ++    +   +HI  + ++
Sbjct: 955  LNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN-ASTYD----QVGRSHITALADY 1009

Query: 968  SIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGE 1027
            ++ LM ++  IN HSFN+F++++G+N GPV+AGVIGARKPQYDIWGNTVNV+SRM+STG 
Sbjct: 1010 AMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGV 1069

Query: 1028 LGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFV 1067
              +IQVT +   +L   GY  ECRG++ VKGKGE+ TYF+
Sbjct: 1070 PDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFL 1109


>gi|4557257 adenylate cyclase 8 [Homo sapiens]
          Length = 1251

 Score =  595 bits (1535), Expect = e-170
 Identities = 388/1102 (35%), Positives = 592/1102 (53%), Gaps = 103/1102 (9%)

Query: 2    PAKGRYFLNEGE--------------EGPDQDALYEKYQLTSQHGPLLLTLLLVAATACV 47
            P+   +FLN G               +  D + LY++Y L  +    ++  +L   T   
Sbjct: 136  PSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLT 195

Query: 48   ALII---IAFSQGDPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACL 104
             L++   +A +  DP +   +LG    +  V  AL V++  +     +L+   ++TW  +
Sbjct: 196  LLVLHLSLASAPMDPLKG-ILLGFFTGIEVVICAL-VVVRKDTTSHTYLQYSGVVTWVAM 253

Query: 105  VA------LGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASH 158
                    LGY L+ D           + + LF +F  Y++LP  +  A+  G + T+  
Sbjct: 254  TTQILAAGLGYGLLGDG----------IGYVLFTLFATYSMLPLPLTWAILAG-LGTSLL 302

Query: 159  LLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQI 218
             ++L  ++      S+    Q++A AV+F+C N  G F  +    A R  F  T +C++ 
Sbjct: 303  QVILQVVIPRLAVISIN---QVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEA 359

Query: 219  RRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNV 278
            R +L  E ++QE L+LSVLP  + + M   +     EH        + FH +Y+ R++NV
Sbjct: 360  RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEH------LQHQFHRIYIHRYENV 413

Query: 279  SILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV 338
            SIL+AD+ GFT L++  S +ELV +LNELF +FD++A  + C+RIKILGDCYYCVSGLP 
Sbjct: 414  SILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPE 473

Query: 339  SLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHD 398
                HA  CV+MGL M + I+ VR  T  D++MR+GIHSG+VLCGV+GLRKWQ+DVWS D
Sbjct: 474  PRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWD 533

Query: 399  VSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQ 458
            V +AN++E+ G+PGR+HI++ATL  L+  Y VE+GHG++R+ +L++ NI TYL+  P   
Sbjct: 534  VDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDS 593

Query: 459  QPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRR 518
                P   +   K   +   R +   T    SW    PF ++  +++  +  T       
Sbjct: 594  LLSLPEDIV---KESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLL 650

Query: 519  PKSVPQR-HRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFL 577
            P  + Q  H ++    ++ +     D    + L              + +    F  +F 
Sbjct: 651  PNHLAQALHVQSGPEEINKRIEHTIDLRSGDKL--------------RREHIKPFSLMFK 696

Query: 578  EKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLL-MPRTAALGVSFGLVACVLGLVL 636
            +   E +Y        + +  CA ++ + I  +  LL   R   + + F ++  +L   L
Sbjct: 697  DSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILI-MLHSAL 755

Query: 637  GLCFATKFSRCCPA--RGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQV 694
             L    +  +C P   R T C I+E      L R  +   +I      AI+N+    F  
Sbjct: 756  VLITTAEDYKCLPLILRKTCCWINETY----LARNVIIFASILINFLGAILNILWCDFD- 810

Query: 695  PELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVA 754
              +P+ N T    +S+    +C    Y+  + VL  + C+VFLR++   K+ +L + +  
Sbjct: 811  KSIPLKNLT--FNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAI 868

Query: 755  YLVLFNLSPCWQWDCCGQGL----GNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITL 810
            Y +L         +    GL     NL        GT   S   L  M  F L +FY   
Sbjct: 869  YALLT--------ETVYAGLFLRYDNLNHSGEDFLGTKEVS---LLLMAMFLLAVFYH-- 915

Query: 811  LTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKLNED 869
                +Q++Y  RLD LW+ + K+E  E + +   N  +L N+LP+HVA HF+  D+ NE+
Sbjct: 916  ---GQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEE 972

Query: 870  WYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEK 929
             Y QSYD V VMFAS+P F  FY++ ++N +G+ECLRLLNEIIADFDELL + +F  +EK
Sbjct: 973  LYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEK 1032

Query: 930  IKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLR 989
            IKTIGSTYMA +GLS     E Q+ E +  H+  + +FS+AL   +  IN+HSFN+F LR
Sbjct: 1033 IKTIGSTYMAVSGLSP----EKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELR 1088

Query: 990  VGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCE 1049
            +GI+HG V+AGVIGA+KPQYDIWG TVN+ASRM+STG  G+IQV EET  IL+  G++ +
Sbjct: 1089 IGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFD 1148

Query: 1050 CRGLINVKG----KGELRTYFV 1067
             RG I VKG    +G+++TYF+
Sbjct: 1149 YRGEIYVKGISEQEGKIKTYFL 1170


>gi|31083193 adenylate cyclase 1 [Homo sapiens]
          Length = 1119

 Score =  592 bits (1526), Expect = e-169
 Identities = 411/1086 (37%), Positives = 587/1086 (54%), Gaps = 108/1086 (9%)

Query: 16   PDQDALYEKYQLTSQHGPLLLTL----LLVAATACVALI-----IIAFSQGDPSRHQAIL 66
            P+ +AL+  Y L  +    L  L    LL  A A   L+         ++G    H  +L
Sbjct: 43   PELEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVH-CVL 101

Query: 67   GMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKA--ACAWE 124
             +A LV+    +L V    +      L +L      C  ALG      A      A A +
Sbjct: 102  FLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQ 161

Query: 125  QVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANA 184
             V   L + FV Y LLP     A+  G V  ASHLLV  +L+        R+   L ANA
Sbjct: 162  GVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLV---PAKRPRLWRTLGANA 218

Query: 185  VIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMG 244
            ++F+  N+ G F +   + + R  F     CI+ R +L  E  +QE LL+S+LP +++M 
Sbjct: 219  LLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAME 278

Query: 245  MKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVL 304
            MK   ++           P+  FH +Y++RH NVSIL+ADIVGFT LAS C+ +ELV +L
Sbjct: 279  MKEDFLKP----------PERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLL 328

Query: 305  NELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREA 364
            NELFGKFD++A  N C RIKILGDCYYCVSGL      HA  CV+MGLDM   I  V EA
Sbjct: 329  NELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEA 388

Query: 365  TGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHL 424
            T VD+NMRVG+H+G VLCGV+GLRKWQYDVWS+DV+LAN MEAAG+PG+VHIT+ TL  L
Sbjct: 389  TEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACL 448

Query: 425  DKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA---- 480
            +  YEVE G+G +R+ +LK  NI T+ ++ P  ++   P   L   K    +K +     
Sbjct: 449  NGDYEVEPGYGHERNSFLKTHNIETFFIV-PSHRRKIFPGLILSDIKPAKRMKFKTVCYL 507

Query: 481  SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSM---SPK 537
             V++    + + A  PF+++     ++  +       R  S   R+R +   ++   +P 
Sbjct: 508  LVQLMHCRKMFKAEIPFSNV-----MTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPG 562

Query: 538  GRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDF 597
             R   + Y   +L A +             +F+T     +E+  E++Y      + + ++
Sbjct: 563  TRV--NRYISRLLEARQTELEMADL-----NFFTLKYKHVER--EQKYH-----QLQDEY 608

Query: 598  ACASLIFVCIL-----LVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARG 652
              ++++   IL     LV++L+ P++         V  +L LV  +CF       C    
Sbjct: 609  FTSAVVLTLILAALFGLVYLLIFPQS---------VVVLLLLVFCICFLV----AC---- 651

Query: 653  TLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELP------VGNETGLL 706
             L     RV+  P   LT+ + T+  +  V +I        V  LP        +   +L
Sbjct: 652  VLYLHITRVQCFPGC-LTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVL 710

Query: 707  AASSKTRAL----CEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLS 762
            ++  +  AL    CE   +    C++G +  ++F R+S  PK++LL+    +Y+++  LS
Sbjct: 711  SSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELS 770

Query: 763  PCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCR 822
                        G      G  SG    S++ +       ++LF   L   +RQ+D   R
Sbjct: 771  ------------GYTRTGGGAVSGR---SYEPIVA-----ILLFSCALALHARQVDIRLR 810

Query: 823  LDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFI-GDKLNEDWYHQSYDCVCVM 881
            LD LW  + ++E E+ E ++  NR +L N+LPAHVA HF+  +  N D Y+QSY  V VM
Sbjct: 811  LDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVM 870

Query: 882  FASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAA 941
            FAS+P+F  FY E D N  G+ECLRLLNEIIADFDEL+ K  +  +EKIKTIGSTYMAA 
Sbjct: 871  FASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAV 930

Query: 942  GLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGV 1001
            GL+  SG   +  +   +H+  + +F+I +   LD IN  S+N F LRVGIN GPV+AGV
Sbjct: 931  GLAPTSG--TKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGV 988

Query: 1002 IGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGE 1061
            IGAR+PQYDIWGNTVNVASRM+STG  G+IQVTEE   +L+   Y   CRG ++VKGKGE
Sbjct: 989  IGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGE 1048

Query: 1062 LRTYFV 1067
            + TYF+
Sbjct: 1049 MLTYFL 1054


>gi|148536830 adenylate cyclase 3 [Homo sapiens]
          Length = 1144

 Score =  563 bits (1450), Expect = e-160
 Identities = 381/1083 (35%), Positives = 569/1083 (52%), Gaps = 64/1083 (5%)

Query: 21   LYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFS-QGDPSRHQAILGMAFLVLAVFAAL 79
            LY+ Y    +H  LL+ ++  A   C  +++ A     D     A+ G+  +       L
Sbjct: 65   LYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLV-------L 117

Query: 80   SVLMYVEC---LL--RRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVF 134
             ++++V C   LL  R   R L  + W  + A  +  +   + +A  A + V + +F VF
Sbjct: 118  DIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVF 177

Query: 135  VVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLL----ANAVIFLCG 190
              +  LP S+   V +  VS   H LVLG  +       ++ G+QLL    AN  ++LC 
Sbjct: 178  SFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELK-GMQLLREILANVFLYLCA 236

Query: 191  NLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAII 250
               G    +      R  F    + ++++  L  + +QQENL+LS+LP H++  M    +
Sbjct: 237  IAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEM----L 292

Query: 251  ERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGK 310
            + +K+  D        F+++Y+ RH+NVSIL+ADIVGFTQL+S CS +ELV +LNELF +
Sbjct: 293  KDMKK--DESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFAR 350

Query: 311  FDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDIN 370
            FD++A     +RIKILGDCYYC+ GLP     HA   + MGL M +AI  VRE T   ++
Sbjct: 351  FDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVD 410

Query: 371  MRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEV 430
            MRVG+H+G VL GV+G ++WQYDVWS DV++AN+MEA G+PGRVHI+++T+  L   ++V
Sbjct: 411  MRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDV 470

Query: 431  EDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQH----LPRPKGDAALKMRASVRMTR 486
            E G G  R  YL+E  I TYL+I  + +     +Q+       P G  A    +S  +  
Sbjct: 471  EPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIE 530

Query: 487  YLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYD 546
              E  G+A      + +      +   P+   P+    R  R  D +      SED+   
Sbjct: 531  TKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPR----RRLRLQDLADRVVDASEDEHEL 586

Query: 547  DEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVC 606
            +++L+    L        K  + +     F++   E  Y +    ++   F+C+ ++ +C
Sbjct: 587  NQLLNEAL-LERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLC 645

Query: 607  ILLVHVLLMPRTAALGVSFGLVACVLGLVLGLC-FATKFSRCCPARGTLCTISERVETQP 665
              LV +L+ P      V+F +V  +L L+L +C  A  F R  P +  L   S  ++   
Sbjct: 646  TALVEILIDPWLMTNYVTF-MVGEILLLILTICSLAAIFPRAFPKK--LVAFSTWIDRTR 702

Query: 666  LLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLLAASSKTRALCEPLP-YYTC 724
              R T A+L I  L+   ++++ L   Q    P     G+     +T   C   P YY  
Sbjct: 703  WARNTWAMLAIFILVMANVVDM-LSCLQYYTGPSNATAGM-----ETEGSCLENPKYYNY 756

Query: 725  SCVLGFIACSVFLRMS--LEPKVVLLTVALVAYLVLFNLSPCW---------QWDCCGQG 773
              VL  IA  + +++S  ++  ++LL    VA + L+   P +         + D     
Sbjct: 757  VAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVA 816

Query: 774  LGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFKK 833
            L  +   N   +GT        K      + L  ++    SR ++   R   LWK +   
Sbjct: 817  LEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHD 876

Query: 834  EHEEFETMENVNRLLLENVLPAHVAAHFIGD-KLNEDWYHQSYDCVCVMFASVPDFKVFY 892
            + E    M   N  L+ N+LP HVA HF+G  K +E+ Y Q+YD + VMFAS+P+F  FY
Sbjct: 877  QKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFY 936

Query: 893  TECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLS-------V 945
            TE  +N  G+ECLR LNEII+DFD LL  PKF  + KIKTIGSTYMAA+G++        
Sbjct: 937  TEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGF 996

Query: 946  ASGHENQELERQH-AHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGA 1004
            AS ++  + ER+   H+  + +F++A+   L  IN  SFN+F LR+G+N G V+AGVIGA
Sbjct: 997  ASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGA 1056

Query: 1005 RKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRT 1064
            RKP YDIWGNTVNVASRMESTG +G IQV EET  IL+  G+    RG I VKGKGEL T
Sbjct: 1057 RKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLT 1116

Query: 1065 YFV 1067
            +F+
Sbjct: 1117 FFL 1119


>gi|50959205 adenylate cyclase 9 [Homo sapiens]
          Length = 1353

 Score =  202 bits (513), Expect = 2e-51
 Identities = 120/275 (43%), Positives = 172/275 (62%), Gaps = 18/275 (6%)

Query: 803  LVLFYITLLT--LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAH 860
            LV F + LL   L+R+ +   RL      +      + ++M +    LL N++P HVA  
Sbjct: 984  LVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQ 1043

Query: 861  FIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEG-LECLRLLNEIIADFDELL 919
                K+++  Y +++D   V+FAS+ +F  FY E   N EG  EC R+LNE+I DFDELL
Sbjct: 1044 L---KVSQT-YSKNHDSGGVIFASIVNFSEFYEE---NYEGGKECYRVLNELIGDFDELL 1096

Query: 920  LKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGIN 979
             KP +S +EKIKTIG+TYMAA+GL+ A   +    +    H+ ++ EF+  +M  +D  N
Sbjct: 1097 SKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQE---HLQILFEFAKEMMRVVDDFN 1153

Query: 980  RHS--FNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEET 1037
             +   FN F+LRVG NHGP+ AGVIG  K  YDIWG+TVN+ASRM++TG   +IQV+EE+
Sbjct: 1154 NNMLWFN-FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEES 1212

Query: 1038 CTILQGLGYSCECRGLINVKGKGELRTYFV--CTD 1070
              +L  +GY  + RG +NVKGKG+++TY    CTD
Sbjct: 1213 YRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTD 1247



 Score =  196 bits (497), Expect = 1e-49
 Identities = 120/351 (34%), Positives = 193/351 (54%), Gaps = 25/351 (7%)

Query: 132 IVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGL---QLLANAVIFL 188
           ++F++YT++   +  ++ +G   +                PS   G    +LL+  ++  
Sbjct: 230 VLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHG 289

Query: 189 CGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLA 248
           C +  G       Q  SR  F    + I   + L +EK  +E ++ SV+P  I+  +   
Sbjct: 290 CIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQ 349

Query: 249 IIERLKEHGDRRCM--PDNN------------FHSLYVKRHQNVSILYADIVGFTQLASD 294
             E  +    R     P N             F    +++ + VSIL+ADIVGFT+++++
Sbjct: 350 GDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSAN 409

Query: 295 CSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDM 354
            S   LV +LN+LFG+FD++ +  +C +I  LGDCYYCV+G P     HA  C++MGL M
Sbjct: 410 KSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGM 469

Query: 355 CQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRV 414
            +AI+Q  +     +NMRVG+H+G VLCG++G+R++++DVWS+DV+LAN ME  GV G+V
Sbjct: 470 IKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKV 529

Query: 415 HITEATLKHLDKAYEVEDGHGQQR------DPYLKEMNIRTYLVIDPRSQQ 459
           HI+EAT K+LD  YE+EDG   +R         LK   ++TYL+   R+++
Sbjct: 530 HISEATAKYLDDRYEMEDGKVIERLGQSVVADQLK--GLKTYLISGQRAKE 578



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 57/208 (27%), Positives = 95/208 (45%), Gaps = 25/208 (12%)

Query: 873  QSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKT 932
            Q  + V ++FA +    V +T+   NK     + LLN++   FD L  + K    EKI T
Sbjct: 388  QQIEEVSILFADI----VGFTKMSANKSAHALVGLLNDLFGRFDRLCEETK---CEKIST 440

Query: 933  IGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGI 992
            +G  Y   AG            E +  H    +E  + ++  ++   +       +RVG+
Sbjct: 441  LGDCYYCVAGCP----------EPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGV 490

Query: 993  NHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRG 1052
            + G V+ G++G R+ ++D+W N VN+A+ ME  G  GK+ ++E T   L    Y  E   
Sbjct: 491  HTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDD-RYEMEDGK 549

Query: 1053 LINVKGKG-------ELRTYFVCTDTAK 1073
            +I   G+         L+TY +    AK
Sbjct: 550  VIERLGQSVVADQLKGLKTYLISGQRAK 577



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 65/260 (25%), Positives = 115/260 (44%), Gaps = 42/260 (16%)

Query: 180  LLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPA 239
            LL   V FL      ++  H   D   DL          R K++  + Q + LL +++P 
Sbjct: 988  LLLLLVWFLNREFEVSYRLHYHGDVEADLH---------RTKIQSMRDQADWLLRNIIPY 1038

Query: 240  HISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDC--SP 297
            H++  +K++                      Y K H +  +++A IV F++   +     
Sbjct: 1039 HVAEQLKVS--------------------QTYSKNHDSGGVIFASIVNFSEFYEENYEGG 1078

Query: 298  KELVVVLNELFGKFDQIAKA---NECMRIKILGDCYYCVSGLPVSLP---THARNCVKMG 351
            KE   VLNEL G FD++      +   +IK +G  Y   SGL  +     +H +  +++ 
Sbjct: 1079 KECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQIL 1138

Query: 352  LDMCQAIKQV-----REATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRME 406
             +  + + +V           +  +RVG + G +  GVIG  K  YD+W   V++A+RM+
Sbjct: 1139 FEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMD 1198

Query: 407  AAGVPGRVHITEATLKHLDK 426
              GV  R+ ++E + + L K
Sbjct: 1199 TTGVECRIQVSEESYRVLSK 1218


>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
          Length = 1061

 Score =  118 bits (295), Expect = 3e-26
 Identities = 85/258 (32%), Positives = 133/258 (51%), Gaps = 26/258 (10%)

Query: 813  LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYH 872
            LSR   Y   L+ L +++ +   EE    E     LL  +LP  VA      K  E    
Sbjct: 817  LSRMEQYANNLEELVEERTQAYLEEKRKAE----ALLYQILPHSVAEQL---KRGETVQA 869

Query: 873  QSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKT 932
            +++D V + F+ +    V +T        ++ + LLN++   FD ++    F  V K++T
Sbjct: 870  EAFDSVTIYFSDI----VGFTALSAESTPMQVVTLLNDLYTCFDAVI--DNFD-VYKVET 922

Query: 933  IGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDG--INRHSFNSFRLRV 990
            IG  YM  +GL V +G           H   +   ++AL+  +    I        RLR+
Sbjct: 923  IGDAYMVVSGLPVRNGR---------LHACEVARMALALLDAVRSFRIRHRPQEQLRLRI 973

Query: 991  GINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGL-GYSCE 1049
            GI+ GPV AGV+G + P+Y ++G+TVN ASRMES GE  KI ++ ET  +L+   G+  E
Sbjct: 974  GIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELE 1033

Query: 1050 CRGLINVKGKGELRTYFV 1067
             RG + +KGKG++RTY++
Sbjct: 1034 LRGDVEMKGKGKVRTYWL 1051



 Score =  103 bits (258), Expect = 7e-22
 Identities = 70/238 (29%), Positives = 130/238 (54%), Gaps = 29/238 (12%)

Query: 225  EKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYAD 284
            EKR+ E LL  +LP  ++        E+LK              ++  +   +V+I ++D
Sbjct: 841  EKRKAEALLYQILPHSVA--------EQLKRG-----------ETVQAEAFDSVTIYFSD 881

Query: 285  IVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV-SLPTH 343
            IVGFT L+++ +P ++V +LN+L+  FD +    +  +++ +GD Y  VSGLPV +   H
Sbjct: 882  IVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLH 941

Query: 344  ARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSL 401
            A    +M L +  A++  ++R      + +R+GIH+G V  GV+GL+  +Y ++   V+ 
Sbjct: 942  ACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNT 1001

Query: 402  ANRMEAAGVPGRVHITEATLKHLDK--AYEVEDGHGQQRDPYLK-EMNIRTYLVIDPR 456
            A+RME+ G   ++H++  T   L++   +E+E     + D  +K +  +RTY ++  R
Sbjct: 1002 ASRMESNGEALKIHLSSETKAVLEEFGGFELE----LRGDVEMKGKGKVRTYWLLGER 1055


>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
           sapiens]
          Length = 455

 Score =  118 bits (295), Expect = 3e-26
 Identities = 62/208 (29%), Positives = 111/208 (53%), Gaps = 19/208 (9%)

Query: 217 QIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQ 276
           Q  + L  EK++  +LL S+ P  ++  +    +                   +  K+  
Sbjct: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV-------------------VQAKKFS 243

Query: 277 NVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGL 336
           NV++L++DIVGFT + S CSP +++ +LN L+ +FDQ     +  +++ +GD Y    GL
Sbjct: 244 NVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL 303

Query: 337 PVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWS 396
                THA     M L M +   +V    G  I MR+G+HSG+V  GV+G++  +Y ++ 
Sbjct: 304 HKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFG 363

Query: 397 HDVSLANRMEAAGVPGRVHITEATLKHL 424
           ++V+LAN+ E+  VP +++++  T + L
Sbjct: 364 NNVTLANKFESCSVPRKINVSPTTYRLL 391



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 54/227 (23%), Positives = 105/227 (46%), Gaps = 26/227 (11%)

Query: 828  KKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPD 887
            K   ++ H+  E  +     LL ++ P  VA      ++ +    + +  V ++F+ +  
Sbjct: 198  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQA---KKFSNVTMLFSDIVG 254

Query: 888  FKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVAS 947
            F    ++C      L+ + +LN +   FD+   +     V K++TIG  Y  A GL    
Sbjct: 255  FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGL---- 303

Query: 948  GHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKP 1007
               ++E +     I +M   ++ +M   D +        ++R+G++ G V AGV+G + P
Sbjct: 304  ---HKESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 357

Query: 1008 QYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLI 1054
            +Y ++GN V +A++ ES     KI V+  T  +L+      +C G +
Sbjct: 358  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLK------DCPGFV 398


>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  118 bits (295), Expect = 3e-26
 Identities = 62/208 (29%), Positives = 111/208 (53%), Gaps = 19/208 (9%)

Query: 217 QIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQ 276
           Q  + L  EK++  +LL S+ P  ++  +    +                   +  K+  
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV-------------------VQAKKFS 478

Query: 277 NVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGL 336
           NV++L++DIVGFT + S CSP +++ +LN L+ +FDQ     +  +++ +GD Y    GL
Sbjct: 479 NVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL 538

Query: 337 PVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWS 396
                THA     M L M +   +V    G  I MR+G+HSG+V  GV+G++  +Y ++ 
Sbjct: 539 HKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFG 598

Query: 397 HDVSLANRMEAAGVPGRVHITEATLKHL 424
           ++V+LAN+ E+  VP +++++  T + L
Sbjct: 599 NNVTLANKFESCSVPRKINVSPTTYRLL 626



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 54/227 (23%), Positives = 105/227 (46%), Gaps = 26/227 (11%)

Query: 828  KKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPD 887
            K   ++ H+  E  +     LL ++ P  VA      ++ +    + +  V ++F+ +  
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQA---KKFSNVTMLFSDIVG 489

Query: 888  FKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVAS 947
            F    ++C      L+ + +LN +   FD+   +     V K++TIG  Y  A GL    
Sbjct: 490  FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGL---- 538

Query: 948  GHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKP 1007
               ++E +     I +M   ++ +M   D +        ++R+G++ G V AGV+G + P
Sbjct: 539  ---HKESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1008 QYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLI 1054
            +Y ++GN V +A++ ES     KI V+  T  +L+      +C G +
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLK------DCPGFV 633


>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  118 bits (295), Expect = 3e-26
 Identities = 62/208 (29%), Positives = 111/208 (53%), Gaps = 19/208 (9%)

Query: 217 QIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQ 276
           Q  + L  EK++  +LL S+ P  ++  +    +                   +  K+  
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV-------------------VQAKKFS 478

Query: 277 NVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGL 336
           NV++L++DIVGFT + S CSP +++ +LN L+ +FDQ     +  +++ +GD Y    GL
Sbjct: 479 NVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL 538

Query: 337 PVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWS 396
                THA     M L M +   +V    G  I MR+G+HSG+V  GV+G++  +Y ++ 
Sbjct: 539 HKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFG 598

Query: 397 HDVSLANRMEAAGVPGRVHITEATLKHL 424
           ++V+LAN+ E+  VP +++++  T + L
Sbjct: 599 NNVTLANKFESCSVPRKINVSPTTYRLL 626



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 54/227 (23%), Positives = 105/227 (46%), Gaps = 26/227 (11%)

Query: 828  KKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPD 887
            K   ++ H+  E  +     LL ++ P  VA      ++ +    + +  V ++F+ +  
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQA---KKFSNVTMLFSDIVG 489

Query: 888  FKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVAS 947
            F    ++C      L+ + +LN +   FD+   +     V K++TIG  Y  A GL    
Sbjct: 490  FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGL---- 538

Query: 948  GHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKP 1007
               ++E +     I +M   ++ +M   D +        ++R+G++ G V AGV+G + P
Sbjct: 539  ---HKESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1008 QYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLI 1054
            +Y ++GN V +A++ ES     KI V+  T  +L+      +C G +
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLK------DCPGFV 633


>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  118 bits (295), Expect = 3e-26
 Identities = 62/208 (29%), Positives = 111/208 (53%), Gaps = 19/208 (9%)

Query: 217 QIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQ 276
           Q  + L  EK++  +LL S+ P  ++  +    +                   +  K+  
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV-------------------VQAKKFS 478

Query: 277 NVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGL 336
           NV++L++DIVGFT + S CSP +++ +LN L+ +FDQ     +  +++ +GD Y    GL
Sbjct: 479 NVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL 538

Query: 337 PVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWS 396
                THA     M L M +   +V    G  I MR+G+HSG+V  GV+G++  +Y ++ 
Sbjct: 539 HKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFG 598

Query: 397 HDVSLANRMEAAGVPGRVHITEATLKHL 424
           ++V+LAN+ E+  VP +++++  T + L
Sbjct: 599 NNVTLANKFESCSVPRKINVSPTTYRLL 626



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 54/227 (23%), Positives = 105/227 (46%), Gaps = 26/227 (11%)

Query: 828  KKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPD 887
            K   ++ H+  E  +     LL ++ P  VA      ++ +    + +  V ++F+ +  
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQA---KKFSNVTMLFSDIVG 489

Query: 888  FKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVAS 947
            F    ++C      L+ + +LN +   FD+   +     V K++TIG  Y  A GL    
Sbjct: 490  FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGL---- 538

Query: 948  GHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKP 1007
               ++E +     I +M   ++ +M   D +        ++R+G++ G V AGV+G + P
Sbjct: 539  ---HKESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1008 QYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLI 1054
            +Y ++GN V +A++ ES     KI V+  T  +L+      +C G +
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLK------DCPGFV 633


>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  118 bits (295), Expect = 3e-26
 Identities = 62/208 (29%), Positives = 111/208 (53%), Gaps = 19/208 (9%)

Query: 217 QIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQ 276
           Q  + L  EK++  +LL S+ P  ++  +    +                   +  K+  
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV-------------------VQAKKFS 478

Query: 277 NVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGL 336
           NV++L++DIVGFT + S CSP +++ +LN L+ +FDQ     +  +++ +GD Y    GL
Sbjct: 479 NVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL 538

Query: 337 PVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWS 396
                THA     M L M +   +V    G  I MR+G+HSG+V  GV+G++  +Y ++ 
Sbjct: 539 HKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFG 598

Query: 397 HDVSLANRMEAAGVPGRVHITEATLKHL 424
           ++V+LAN+ E+  VP +++++  T + L
Sbjct: 599 NNVTLANKFESCSVPRKINVSPTTYRLL 626



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 54/227 (23%), Positives = 105/227 (46%), Gaps = 26/227 (11%)

Query: 828  KKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPD 887
            K   ++ H+  E  +     LL ++ P  VA      ++ +    + +  V ++F+ +  
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQA---KKFSNVTMLFSDIVG 489

Query: 888  FKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVAS 947
            F    ++C      L+ + +LN +   FD+   +     V K++TIG  Y  A GL    
Sbjct: 490  FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGL---- 538

Query: 948  GHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKP 1007
               ++E +     I +M   ++ +M   D +        ++R+G++ G V AGV+G + P
Sbjct: 539  ---HKESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1008 QYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLI 1054
            +Y ++GN V +A++ ES     KI V+  T  +L+      +C G +
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLK------DCPGFV 633


>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
           sapiens]
          Length = 624

 Score =  117 bits (294), Expect = 4e-26
 Identities = 61/206 (29%), Positives = 110/206 (53%), Gaps = 19/206 (9%)

Query: 217 QIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQ 276
           Q  + L  EK++  +LL S+ P  ++  +    +                   +  K+  
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV-------------------VQAKKFS 478

Query: 277 NVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGL 336
           NV++L++DIVGFT + S CSP +++ +LN L+ +FDQ     +  +++ +GD Y    GL
Sbjct: 479 NVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGL 538

Query: 337 PVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWS 396
                THA     M L M +   +V    G  I MR+G+HSG+V  GV+G++  +Y ++ 
Sbjct: 539 HKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFG 598

Query: 397 HDVSLANRMEAAGVPGRVHITEATLK 422
           ++V+LAN+ E+  VP +++++  T +
Sbjct: 599 NNVTLANKFESCSVPRKINVSPTTYR 624



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 51/210 (24%), Positives = 98/210 (46%), Gaps = 20/210 (9%)

Query: 828  KKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPD 887
            K   ++ H+  E  +     LL ++ P  VA      ++ +    + +  V ++F+ +  
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQA---KKFSNVTMLFSDIVG 489

Query: 888  FKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVAS 947
            F    ++C      L+ + +LN +   FD+   +     V K++TIG  Y  A GL    
Sbjct: 490  FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGL---- 538

Query: 948  GHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKP 1007
               ++E +     I +M   ++ +M   D +        ++R+G++ G V AGV+G + P
Sbjct: 539  ---HKESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592

Query: 1008 QYDIWGNTVNVASRMESTGELGKIQVTEET 1037
            +Y ++GN V +A++ ES     KI V+  T
Sbjct: 593  RYCLFGNNVTLANKFESCSVPRKINVSPTT 622


>gi|134152694 guanylate cyclase 2F [Homo sapiens]
          Length = 1108

 Score =  113 bits (283), Expect = 8e-25
 Identities = 69/217 (31%), Positives = 122/217 (56%), Gaps = 25/217 (11%)

Query: 221  KLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSI 280
            +L IEK++ E LL  +LP  ++  +K            + C  +     L       V++
Sbjct: 845  ELEIEKQKTEKLLTQMLPPSVAESLK------------KGCTVEPEGFDL-------VTL 885

Query: 281  LYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSL 340
             ++DIVGFT +++   P E+V +LN+L+  FD I  +++  +++ +GD Y   SGLP   
Sbjct: 886  YFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRN 945

Query: 341  PT-HARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSH 397
             + HA     M LD+  ++   ++R    V + +R+G+HSG V+ GV+GL   +Y ++  
Sbjct: 946  GSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGD 1005

Query: 398  DVSLANRMEAAGVPGRVHITEAT---LKHLDKAYEVE 431
             V+ A+RME+ G+P R+H++ +T   L++L + YEVE
Sbjct: 1006 TVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042



 Score =  110 bits (275), Expect = 7e-24
 Identities = 78/240 (32%), Positives = 119/240 (49%), Gaps = 23/240 (9%)

Query: 832  KKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVF 891
            ++  EE E  +     LL  +LP  VA         E    + +D V + F+ +    V 
Sbjct: 840  RERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEP---EGFDLVTLYFSDI----VG 892

Query: 892  YTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHEN 951
            +T      E +E + LLN++   FD ++       V K++TIG  YM A+GL   +G   
Sbjct: 893  FTTISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPKRNGSR- 948

Query: 952  QELERQHAHIGVMVEFSIALMSKLDGINRHSFNSF--RLRVGINHGPVIAGVIGARKPQY 1009
                    H   +   S+ ++S +             R+R+G++ GPV+AGV+G   P+Y
Sbjct: 949  --------HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRY 1000

Query: 1010 DIWGNTVNVASRMESTGELGKIQVTEETCTILQGL--GYSCECRGLINVKGKGELRTYFV 1067
             ++G+TVN ASRMESTG   +I V+  T TILQ L  GY  E RG   +KGKG   T+++
Sbjct: 1001 CLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060


>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
          Length = 1047

 Score =  113 bits (282), Expect = 1e-24
 Identities = 82/258 (31%), Positives = 130/258 (50%), Gaps = 26/258 (10%)

Query: 813  LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYH 872
            L R   Y   L+ L +++ +   EE    E     LL  +LP  VA      K  E    
Sbjct: 802  LLRMEQYANNLEKLVEERTQAYLEEKRKAE----ALLYQILPHSVAEQL---KRGETVQA 854

Query: 873  QSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKT 932
            +++D V + F+ +    V +T        ++ + LLN++   FD ++    F  V K++T
Sbjct: 855  EAFDSVTIYFSDI----VGFTALSAESTPMQVVTLLNDLYTCFDAII--DNFD-VYKVET 907

Query: 933  IGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDG--INRHSFNSFRLRV 990
            IG  YM  +GL   +G           H   +   ++AL+  +    I     +  RLR+
Sbjct: 908  IGDAYMVVSGLPGRNGQR---------HAPEIARMALALLDAVSSFRIRHRPHDQLRLRI 958

Query: 991  GINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLG-YSCE 1049
            G++ GPV AGV+G + P+Y ++G+TVN ASRMES G+  KI V+  T   L  LG +  E
Sbjct: 959  GVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLE 1018

Query: 1050 CRGLINVKGKGELRTYFV 1067
             RG + +KGKG++RTY++
Sbjct: 1019 LRGDVEMKGKGKMRTYWL 1036



 Score =  103 bits (256), Expect = 1e-21
 Identities = 70/242 (28%), Positives = 129/242 (53%), Gaps = 29/242 (11%)

Query: 225  EKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYAD 284
            EKR+ E LL  +LP  ++        E+LK              ++  +   +V+I ++D
Sbjct: 826  EKRKAEALLYQILPHSVA--------EQLKRG-----------ETVQAEAFDSVTIYFSD 866

Query: 285  IVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLP-VSLPTH 343
            IVGFT L+++ +P ++V +LN+L+  FD I    +  +++ +GD Y  VSGLP  +   H
Sbjct: 867  IVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRH 926

Query: 344  ARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSL 401
            A    +M L +  A+   ++R      + +R+G+H+G V  GV+GL+  +Y ++   V+ 
Sbjct: 927  APEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNT 986

Query: 402  ANRMEAAGVPGRVHITEATLKHLDK--AYEVEDGHGQQRDPYLK-EMNIRTYLVIDPRSQ 458
            A+RME+ G   ++H++  T   LD+   +++E     + D  +K +  +RTY ++  R  
Sbjct: 987  ASRMESNGQALKIHVSSTTKDALDELGCFQLE----LRGDVEMKGKGKMRTYWLLGERKG 1042

Query: 459  QP 460
             P
Sbjct: 1043 PP 1044


>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
          Length = 732

 Score =  112 bits (280), Expect = 2e-24
 Identities = 69/253 (27%), Positives = 127/253 (50%), Gaps = 22/253 (8%)

Query: 222 LRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSIL 281
           L  EK++  +LL S+ P  ++  +                        +  ++  +V++L
Sbjct: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQG-------------------QQVQARKFDDVTML 523

Query: 282 YADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLP 341
           ++DIVGFT + + C+P +++ +LNEL+ +FD      +  +++ +GD Y   +GL     
Sbjct: 524 FSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSL 583

Query: 342 THARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSL 401
            HA+    M L M +  ++V    G  I MR+GIHSG+VL GV+G+R  +Y ++ ++V+L
Sbjct: 584 CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTL 643

Query: 402 ANRMEAAGVPGRVHITEAT---LKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQ 458
           A++ E+   P R++++  T   LK  +    +     +  D + KE+    Y +      
Sbjct: 644 ASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGP 703

Query: 459 QPPPPSQHLPRPK 471
           +PP PS    R K
Sbjct: 704 KPPKPSLSSSRIK 716



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 57/222 (25%), Positives = 105/222 (47%), Gaps = 23/222 (10%)

Query: 822  RLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAH-FIGDKLNEDWYHQSYDCVCV 880
            R+D L K   ++ H+  E  +     LL ++ P  VA   + G ++      + +D V +
Sbjct: 468  RMDKL-KATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQA----RKFDDVTM 522

Query: 881  MFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAA 940
            +F+ +  F     +C      ++ + +LNE+   FD    +  F  + K++TIG  Y  A
Sbjct: 523  LFSDIVGFTAICAQCTP----MQVISMLNELYTRFDH---QCGFLDIYKVETIGDAYCVA 575

Query: 941  AGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAG 1000
            AGL            +   H   +   ++ +M   + +        ++R+GI+ G V+AG
Sbjct: 576  AGLH----------RKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAG 625

Query: 1001 VIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQ 1042
            V+G R P+Y ++GN V +AS+ ES     +I V+  T  +L+
Sbjct: 626  VVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLK 667


>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
            sapiens]
          Length = 1103

 Score =  110 bits (274), Expect = 9e-24
 Identities = 65/217 (29%), Positives = 118/217 (54%), Gaps = 25/217 (11%)

Query: 221  KLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSI 280
            +L +EK++ + LL  +LP  ++  +K                       +  +  + V++
Sbjct: 841  ELELEKQKTDRLLTQMLPPSVAEALKTGT-------------------PVEPEYFEQVTL 881

Query: 281  LYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV-S 339
             ++DIVGFT +++   P E+V +LN+L+  FD I  +++  +++ +GD Y   SGLP  +
Sbjct: 882  YFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRN 941

Query: 340  LPTHARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSH 397
               HA     M LD+  A+   ++R    V + +R+G+HSG  + GV+GL   +Y ++  
Sbjct: 942  GQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGD 1001

Query: 398  DVSLANRMEAAGVPGRVHITEAT---LKHLDKAYEVE 431
             V+ A+RME+ G+P R+H+  +T   L+ LD  Y+VE
Sbjct: 1002 TVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038



 Score =  102 bits (255), Expect = 1e-21
 Identities = 76/241 (31%), Positives = 119/241 (49%), Gaps = 25/241 (10%)

Query: 832  KKEHEEFETMENVNRLLLENVLPAHVA-AHFIGDKLNEDWYHQSYDCVCVMFASVPDFKV 890
            ++  EE E  +     LL  +LP  VA A   G  +  +++ Q    V + F+ +    V
Sbjct: 836  RERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDI----V 887

Query: 891  FYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHE 950
             +T      E +E + LLN++   FD ++       V K++TIG  YM A+GL   +G  
Sbjct: 888  GFTTISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPQRNGQR 944

Query: 951  NQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSF--RLRVGINHGPVIAGVIGARKPQ 1008
                     H   +   S+ ++S +             R+R+G++ GP +AGV+G   P+
Sbjct: 945  ---------HAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPR 995

Query: 1009 YDIWGNTVNVASRMESTGELGKIQVTEETCTILQGL--GYSCECRGLINVKGKGELRTYF 1066
            Y ++G+TVN ASRMESTG   +I V   T  IL+ L  GY  E RG   +KGKG   T++
Sbjct: 996  YCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFW 1055

Query: 1067 V 1067
            +
Sbjct: 1056 L 1056


>gi|222080083 guanylate cyclase 2C [Homo sapiens]
          Length = 1073

 Score =  103 bits (257), Expect = 9e-22
 Identities = 62/197 (31%), Positives = 114/197 (57%), Gaps = 8/197 (4%)

Query: 275  HQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVS 334
            ++ V+I ++DIVGFT +    +P E+V +LN+++  FD I   ++  +++ +GD Y   S
Sbjct: 820  YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879

Query: 335  GLPV-SLPTHARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQ 391
            GLP  +   HA +  KM L++   +   ++    G+ I +R+G+HSG    GV+G++  +
Sbjct: 880  GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939

Query: 392  YDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLK-EMNIRTY 450
            Y ++   V+ A+RME+ G+P R+H++ +T+  L K  E +  +  + + YLK   N  TY
Sbjct: 940  YCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL-KRTECQFLYEVRGETYLKGRGNETTY 998

Query: 451  LVIDPRSQQ---PPPPS 464
             +   + Q+   P PP+
Sbjct: 999  WLTGMKDQKFNLPTPPT 1015



 Score = 87.4 bits (215), Expect = 6e-17
 Identities = 73/260 (28%), Positives = 131/260 (50%), Gaps = 26/260 (10%)

Query: 812  TLSRQIDYYCR-LDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAH-FIGDKLNED 869
            TL R++  Y R L+ L +++ +    E +  + +N +LL  ++   +    F+  +L E+
Sbjct: 763  TLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEE 822

Query: 870  WYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEK 929
                    V + F+ +  F    T C  +   +E + +LN+I   FD ++       V K
Sbjct: 823  --------VTIYFSDIVGFT---TICKYSTP-MEVVDMLNDIYKSFDHIV---DHHDVYK 867

Query: 930  IKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLR 989
            ++TIG  YM A+GL   +G+ +  ++     + ++       +  L G+         +R
Sbjct: 868  VETIGDAYMVASGLPKRNGNRHA-IDIAKMALEILSFMGTFELEHLPGL------PIWIR 920

Query: 990  VGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQ--GLGYS 1047
            +G++ GP  AGV+G + P+Y ++G+TVN ASRMESTG   +I V+  T  IL+     + 
Sbjct: 921  IGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFL 980

Query: 1048 CECRGLINVKGKGELRTYFV 1067
             E RG   +KG+G   TY++
Sbjct: 981  YEVRGETYLKGRGNETTYWL 1000


>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
          Length = 619

 Score =  102 bits (254), Expect = 2e-21
 Identities = 67/212 (31%), Positives = 114/212 (53%), Gaps = 27/212 (12%)

Query: 220 RKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVS 279
           R L  EK++ + LL SVLP  ++  ++            +R +P         KR+ NV+
Sbjct: 381 RALEDEKKKTDTLLYSVLPPSVANELR-----------HKRPVP--------AKRYDNVT 421

Query: 280 ILYADIVGFTQLASDCSPKE----LVVVLNELFGKFDQIAKANE---CMRIKILGDCYYC 332
           IL++ IVGF    S  +  E    +V +LN+L+ +FD +  + +     +++ +GD Y  
Sbjct: 422 ILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMT 481

Query: 333 VSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQY 392
           VSGLP     HAR+   + LDM +   QV +  G  + + +GIH+G V+ GVIG R  +Y
Sbjct: 482 VSGLPEPCIHHARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRY 540

Query: 393 DVWSHDVSLANRMEAAGVPGRVHITEATLKHL 424
            ++ + V+L +R E  G  G+++++E T + L
Sbjct: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572



 Score =  100 bits (248), Expect = 1e-20
 Identities = 71/219 (32%), Positives = 112/219 (51%), Gaps = 19/219 (8%)

Query: 848  LLENVLPAHVAAHFIGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRL 907
            LL +VLP  VA      +       + YD V ++F+ +  F  F ++    +  ++ + L
Sbjct: 393  LLYSVLPPSVANEL---RHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNL 449

Query: 908  LNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEF 967
            LN++   FD L    K   V K++T+G  YM  +GL     H  + +     H+ + +  
Sbjct: 450  LNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSI----CHLALDM-M 504

Query: 968  SIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGE 1027
             IA   ++DG       S ++ +GI+ G V+ GVIG R P+Y ++GNTVN+ SR E+TGE
Sbjct: 505  EIAGQVQVDG------ESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGE 558

Query: 1028 LGKIQVTEETCTILQG-----LGYSCECRGLINVKGKGE 1061
             GKI V+E T   L         +  E RG +++KGK E
Sbjct: 559  KGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKE 597


>gi|209976994 adenylate cyclase 10 [Homo sapiens]
          Length = 1610

 Score = 38.5 bits (88), Expect = 0.035
 Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 12/84 (14%)

Query: 327 GDCYYCVSGLP-VSLP---THARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLC 382
           G  + CV G P   +P   THA  C     D C  + +++  +       +G+ SG V C
Sbjct: 341 GCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVS-------IGVASGIVFC 393

Query: 383 GVIG-LRKWQYDVWSHDVSLANRM 405
           G++G   + +Y V    V+LA RM
Sbjct: 394 GIVGHTVRHEYTVIGQKVNLAARM 417


>gi|157388953 G protein-coupled receptor 172B [Homo sapiens]
          Length = 448

 Score = 34.3 bits (77), Expect = 0.65
 Identities = 52/173 (30%), Positives = 73/173 (42%), Gaps = 36/173 (20%)

Query: 15  GPDQDALYEKYQLTSQHGPLLLTLLLV--AATACVALIIIAFS---QGDPSRHQA-ILGM 68
           GPD +A    +QL S HG  LL L+    A T  V   + +FS    G  + H A +LG 
Sbjct: 266 GPDPEA----HQLFSAHGAFLLGLMAFTSAVTNGVLPSVQSFSCLPYGRLAYHLAVVLGS 321

Query: 69  AFLVLAVFAALSV----------LMYVECLLRRWLRALALLTWACL----VALGYVLVFD 114
           A   LA F A+ V          L  +  L   +L ALA+L+  C        G VLV  
Sbjct: 322 AANPLACFLAMGVLCRSLAGLVGLSLLGMLFGAYLMALAILS-PCPPLVGTTAGVVLVVL 380

Query: 115 AWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMG 167
           +W    C       F ++     +LL    R A+    V+     + +GSL+G
Sbjct: 381 SWVLCLCV------FSYVKVAASSLLHGGGRPALLAAGVA-----IQVGSLLG 422


>gi|157388951 G protein-coupled receptor 172B [Homo sapiens]
          Length = 448

 Score = 34.3 bits (77), Expect = 0.65
 Identities = 52/173 (30%), Positives = 73/173 (42%), Gaps = 36/173 (20%)

Query: 15  GPDQDALYEKYQLTSQHGPLLLTLLLV--AATACVALIIIAFS---QGDPSRHQA-ILGM 68
           GPD +A    +QL S HG  LL L+    A T  V   + +FS    G  + H A +LG 
Sbjct: 266 GPDPEA----HQLFSAHGAFLLGLMAFTSAVTNGVLPSVQSFSCLPYGRLAYHLAVVLGS 321

Query: 69  AFLVLAVFAALSV----------LMYVECLLRRWLRALALLTWACL----VALGYVLVFD 114
           A   LA F A+ V          L  +  L   +L ALA+L+  C        G VLV  
Sbjct: 322 AANPLACFLAMGVLCRSLAGLVGLSLLGMLFGAYLMALAILS-PCPPLVGTTAGVVLVVL 380

Query: 115 AWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMG 167
           +W    C       F ++     +LL    R A+    V+     + +GSL+G
Sbjct: 381 SWVLCLCV------FSYVKVAASSLLHGGGRPALLAAGVA-----IQVGSLLG 422


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 34.3 bits (77), Expect = 0.65
 Identities = 32/120 (26%), Positives = 43/120 (35%), Gaps = 26/120 (21%)

Query: 455 PRSQQPPPPSQHLPRPKGDA-----ALKMRASVRMTRYLESWGAA--------------R 495
           P  QQ PPP Q  P P+G A     A +  +   + RYL   G A               
Sbjct: 220 PPQQQQPPPPQPQPPPEGGAVRAGGAARPVSLREVVRYLGGSGGAGGRLTRGRVQGLLEE 279

Query: 496 PFAHLNHRESVSSGETHVPNGRRP-------KSVPQRHRRTPDRSMSPKGRSEDDSYDDE 548
             A     E    G   +P G RP        + P R +R  +  +  K   EDD  D++
Sbjct: 280 EAAARGRLERTRLGALALPRGDRPGRAPPAASARPSRSKRGGEERVLEKEEEEDDDEDED 339


>gi|239756380 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 151

 Score = 33.5 bits (75), Expect = 1.1
 Identities = 30/78 (38%), Positives = 35/78 (44%), Gaps = 6/78 (7%)

Query: 468 PRPKGDAALKMRASV-RMTRYLESWGAARPF--AHLNHRESVSSGETHVPNGRRPKSVPQ 524
           PRP G    +  AS  R +R L S  A  PF  A L    ++SSG   VP  RRP   P 
Sbjct: 51  PRPPGHGCARAAASFGRASRPLGSGAAFDPFKSAPLGAEPALSSGA--VPRARRPPRRPH 108

Query: 525 RHRRTPDRSMSPKGRSED 542
              R P R  +P G   D
Sbjct: 109 PPARLPGRG-TPFGPPRD 125


>gi|239750901 PREDICTED: hypothetical protein XP_002347602 [Homo
           sapiens]
          Length = 151

 Score = 33.5 bits (75), Expect = 1.1
 Identities = 30/78 (38%), Positives = 35/78 (44%), Gaps = 6/78 (7%)

Query: 468 PRPKGDAALKMRASV-RMTRYLESWGAARPF--AHLNHRESVSSGETHVPNGRRPKSVPQ 524
           PRP G    +  AS  R +R L S  A  PF  A L    ++SSG   VP  RRP   P 
Sbjct: 51  PRPPGHGCARAAASFGRASRPLGSGAAFDPFKSAPLGAEPALSSGA--VPRARRPPRRPH 108

Query: 525 RHRRTPDRSMSPKGRSED 542
              R P R  +P G   D
Sbjct: 109 PPARLPGRG-TPFGPPRD 125


>gi|239745293 PREDICTED: hypothetical protein XP_002343426 [Homo
           sapiens]
          Length = 151

 Score = 33.5 bits (75), Expect = 1.1
 Identities = 30/78 (38%), Positives = 35/78 (44%), Gaps = 6/78 (7%)

Query: 468 PRPKGDAALKMRASV-RMTRYLESWGAARPF--AHLNHRESVSSGETHVPNGRRPKSVPQ 524
           PRP G    +  AS  R +R L S  A  PF  A L    ++SSG   VP  RRP   P 
Sbjct: 51  PRPPGHGCARAAASFGRASRPLGSGAAFDPFKSAPLGAEPALSSGA--VPRARRPPRRPH 108

Query: 525 RHRRTPDRSMSPKGRSED 542
              R P R  +P G   D
Sbjct: 109 PPARLPGRG-TPFGPPRD 125


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.430 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,334,537
Number of Sequences: 37866
Number of extensions: 1870467
Number of successful extensions: 7375
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 7180
Number of HSP's gapped (non-prelim): 91
length of query: 1080
length of database: 18,247,518
effective HSP length: 113
effective length of query: 967
effective length of database: 13,968,660
effective search space: 13507694220
effective search space used: 13507694220
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.