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Search of human proteins with 128485503
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|128485503 kelch-like 30 [Homo sapiens]
(560 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|128485503 kelch-like 30 [Homo sapiens] 1151 0.0
gi|55925608 kelch-like 21 [Homo sapiens] 352 5e-97
gi|40018614 DRE1 protein [Homo sapiens] 244 2e-64
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 242 8e-64
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 236 5e-62
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 236 5e-62
gi|166235129 kelch-like 3 [Homo sapiens] 232 8e-61
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 229 7e-60
gi|40255071 kelch-like 23 [Homo sapiens] 226 3e-59
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 225 7e-59
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 225 7e-59
gi|194097389 kelch-like 38 [Homo sapiens] 222 6e-58
gi|40807500 kelch-like 20 [Homo sapiens] 217 2e-56
gi|38194229 kelch-like 17 [Homo sapiens] 217 3e-56
gi|109150407 kelch-like 6 [Homo sapiens] 215 8e-56
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 209 4e-54
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 209 4e-54
gi|14780904 kelch-like 1 protein [Homo sapiens] 208 1e-53
gi|38327518 BTB and kelch domain containing 3 [Homo sapiens] 201 2e-51
gi|38327516 BTB and kelch domain containing 3 [Homo sapiens] 201 2e-51
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 200 3e-51
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 197 2e-50
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 197 2e-50
gi|55925604 kelch-like 18 [Homo sapiens] 194 1e-49
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 192 5e-49
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 192 9e-49
gi|11056006 kelch-like 12 [Homo sapiens] 184 1e-46
gi|148664209 kelch-like 10 [Homo sapiens] 184 2e-46
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 183 3e-46
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 179 8e-45
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 1151 bits (2977), Expect = 0.0
Identities = 560/560 (100%), Positives = 560/560 (100%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
Query: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI
Sbjct: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
Query: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE
Sbjct: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
Query: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDG 240
ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDG
Sbjct: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDG 240
Query: 241 APLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWG 300
APLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWG
Sbjct: 241 APLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWG 300
Query: 301 FSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGE 360
FSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGE
Sbjct: 301 FSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGE 360
Query: 361 IYVIGGTTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALA 420
IYVIGGTTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALA
Sbjct: 361 IYVIGGTTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALA 420
Query: 421 LQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDNTKKVYVYDPGANLWQKVQS 480
LQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDNTKKVYVYDPGANLWQKVQS
Sbjct: 421 LQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDNTKKVYVYDPGANLWQKVQS 480
Query: 481 QHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHGALPRLWLYHGA 540
QHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHGALPRLWLYHGA
Sbjct: 481 QHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHGALPRLWLYHGA 540
Query: 541 STVFLDVSKWTQPSGPTQEH 560
STVFLDVSKWTQPSGPTQEH
Sbjct: 541 STVFLDVSKWTQPSGPTQEH 560
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 352 bits (903), Expect = 5e-97
Identities = 214/560 (38%), Positives = 302/560 (53%), Gaps = 37/560 (6%)
Query: 1 MLDGLQRLRSQPKLADVTL-LVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELR 59
+L GL +LR++ K DVTL GGR+ P HR +LA +SPYF AMFAG ES + RV L
Sbjct: 21 LLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLH 80
Query: 60 DVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLG 119
V P ++ L+DF YTGR+ ++ N E L R A L FP+V++ CG +LQQQLD ANCL
Sbjct: 81 GVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLD 140
Query: 120 ICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRL 179
+ +F E G+A+ A F+ + + E + +LP RL+ L D L V E++
Sbjct: 141 MQDFAEAFSCSGLASAAQRFILRHVGELGAE-QLERLPLARLLRYLRDDGLCVPKEEAAY 199
Query: 180 EALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEAC--------- 230
+ +RWVR DP RAAH P+LL V L V R + + +EPL+ C
Sbjct: 200 QLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARD 259
Query: 231 -RAALSQGHDGAPLALQQK-----LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKA 284
+AA HD P + L E+LV+VGG + +E L YN +
Sbjct: 260 FQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDE--------LVTVDCYNPQT 311
Query: 285 KRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAP 344
+W L +FPD+ G+S+ AL N+IYVTGGS G++ W + W VAP
Sbjct: 312 GQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRL----YDCVWRYNSSVNEWAEVAP 367
Query: 345 MLKPRTNHASAALNGEIYVIGGTTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRG 404
MLK R H+S+ L+G +YV+ + E YD TDSW + P + N S CRG
Sbjct: 368 MLKAREYHSSSVLDGLLYVVAADS-----TERYDHTTDSWEALQPMTYPMDNCSTTACRG 422
Query: 405 RLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDNTKK 464
RLY +GS A K + +QCY+P TD WS++ LP + +P+ A L+G +Y + D++ +
Sbjct: 423 RLYAIGSLAGK-ETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE 481
Query: 465 VYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDT 524
V VY+P N W K+ S + +H G+L LG LYV+GG E +EAYD
Sbjct: 482 VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFE--LSDVVEAYDPETRA 539
Query: 525 WTRHGALPRLWLYHGASTVF 544
W+ G LP +HG+ ++F
Sbjct: 540 WSVVGRLPEPTFWHGSVSIF 559
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 244 bits (622), Expect = 2e-64
Identities = 166/557 (29%), Positives = 259/557 (46%), Gaps = 32/557 (5%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
+L R DV + V G+E PCHR +L+ S YF AMF D ES VE+
Sbjct: 52 ILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEING 111
Query: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
+ + + +VYTG++ IT NV+ L T++ ++ C ++L++QLD NCLGI
Sbjct: 112 ILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGI 171
Query: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
F + L + K F + FE V++ +EFL+L ++ L+ + D L + E+ E
Sbjct: 172 QRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFE 231
Query: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDG 240
A+MRWV R L ELL+ V L + Q + + LIQ S C L +
Sbjct: 232 AVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRY 291
Query: 241 APLALQQK-----------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMA 289
L + EV+VVVGG E G P Y+ W +
Sbjct: 292 HILGNEMMSPRTRPRRSTGYSEVIVVVGGC----ERVGGFNLP---YTECYDPVTGEWKS 344
Query: 290 LPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPR 349
L P++ K +++ AL N+I V+GG ++ W + + W VA + K R
Sbjct: 345 LAKLPEFTKSEYAVCALRNDILVSGGRINSR-------DVWIYNSQLNIWIRVASLNKGR 397
Query: 350 TNHASAALNGEIYVIGGTTLD--VVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLY 407
H A L G++YV+GG + VE YD +++ WT V+P + VS+ + C G+L+
Sbjct: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLF 457
Query: 408 LVGSSACKYNAL-ALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDNTKKVY 466
++G +Q Y+P T++W + A+ +P +L+ +Y+ G TK +Y
Sbjct: 458 VIGGGPDDNTCSDKVQSYDPETNSWLLRAA--IPIAKRCITAVSLNNLIYVAGGLTKAIY 515
Query: 467 VYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWT 526
YDP + W VQ+ S EN + +Y+ GGR + G+ + YD T
Sbjct: 516 CYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRE--NGEATDTILCYDPATSIIT 573
Query: 527 RHGALPRLWLYHGASTV 543
A+PR YHG T+
Sbjct: 574 GVAAMPRPVSYHGCVTI 590
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 242 bits (617), Expect = 8e-64
Identities = 166/579 (28%), Positives = 271/579 (46%), Gaps = 55/579 (9%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
+L L LR DVTL G R PCHR +LA SS YF AMF+ ES V +D
Sbjct: 32 VLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQD 91
Query: 61 -VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLG 119
+ P V+ L+DF Y+ R+ I + N E+L L F V+ +L++ L +NCLG
Sbjct: 92 NLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCLG 151
Query: 120 ICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRL 179
+ + + +W +FE V + ++F L ++ L+ ++ D L+ + E+
Sbjct: 152 MMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVVF 211
Query: 180 EALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQG-- 237
EA+++WV+HD + R HLPELL V L +P C+Q+ ++SE L+ E + + +
Sbjct: 212 EAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEALR 271
Query: 238 -------HDG---APLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRW 287
+DG +P A +K L+++GGQ ++ + + KAK
Sbjct: 272 CKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQ-----------VDHKAKEI 320
Query: 288 MALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLK 347
+ D P K FS +A+ +YVTGG RG++ + W + W APML
Sbjct: 321 IPKADLPSPRK-EFSASAIGCKVYVTGG-RGSENGV--SKDVWVYDTVHEEWSKAAPMLI 376
Query: 348 PRTNHASAALNGEIYVIGGTT-----------LDVVEVESYDPYTDSWTPVSPALKYVSN 396
R H SA L +YV+GG T + + +VE YDP + W V+P VSN
Sbjct: 377 ARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSN 436
Query: 397 FSAAGCRGRLYLVGSSACKYNALA-LQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGEL 455
+ + +L++ G ++ + ++ +QCY+P + W++ A P+ A L ++
Sbjct: 437 AAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAE--CPQPWRYTAAAVLGSQI 494
Query: 456 YLIGDNTK----KVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDY 511
+++G +T+ Y +D N W ++ + + + G+ LYV GG +
Sbjct: 495 FIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCK- 553
Query: 512 HVEMEAYDTVRDTWTRHGALPRLWLYHGASTVFLDVSKW 550
++ YD DTW +P Y T F VS W
Sbjct: 554 --TLDCYDPTSDTWNCITTVP----YSLIPTAF--VSTW 584
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 236 bits (601), Expect = 5e-62
Identities = 160/551 (29%), Positives = 258/551 (46%), Gaps = 54/551 (9%)
Query: 5 LQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPA 64
+ LRSQ L DVT++ E+ HR +LA SPYFHAMF G+ +ES + RV +++V+
Sbjct: 50 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 109
Query: 65 VVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFG 124
+ L+D+VYT + +T+ NV+ L A L V+K C +L+ QL NCLGI F
Sbjct: 110 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 169
Query: 125 EQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMR 184
+ + KA + ++F V +EFL L E++ + ++ D L + E+ EA++
Sbjct: 170 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 229
Query: 185 WVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLA 244
WV HD R + L+ V L +PR + Q + E L++ S AC+ L + L
Sbjct: 230 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 289
Query: 245 LQQK---------------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMA 289
+Q+ L +++VVVGGQA + + Y+ K +RW
Sbjct: 290 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQA----------PKAIRSVECYDFKEERWHQ 339
Query: 290 LPDFPDYHKWGFSLAALNNNIYVTGGSRGT----KTDTWSTTQAWCFPLKEASWKPVAPM 345
+ + P + + + ++ GG G+ D++ P+K+ W VA M
Sbjct: 340 VAELPS-RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYD-------PVKD-QWTSVANM 390
Query: 346 LKPRTNHASAALNGEIYVIGG--TTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCR 403
R+ +A LNG +Y +GG + + VE+Y+ ++ W V+P S+
Sbjct: 391 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 450
Query: 404 GRLYLVG--SSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN 461
G LY VG A + ++CYN T+ W+ IA + S L+ LY +G +
Sbjct: 451 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE--MSTRRSGAGVGVLNNLLYAVGGH 508
Query: 462 -----TKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHV-EM 515
K V VYDP N W++V + N + + LYV GG +G ++ +
Sbjct: 509 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD----DGSCNLASV 564
Query: 516 EAYDTVRDTWT 526
E Y+ D WT
Sbjct: 565 EYYNPTTDKWT 575
Score = 76.6 bits (187), Expect = 5e-14
Identities = 47/172 (27%), Positives = 74/172 (43%), Gaps = 5/172 (2%)
Query: 267 GEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWST 326
G + + GL + YN K+ W + + + + + +Y GG G ST
Sbjct: 411 GFDGSTGLSSVEAYNIKSNEWFHVAPM-NTRRSSVGVGVVGGLLYAVGGYDGASRQCLST 469
Query: 327 TQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTTLDVVE--VESYDPYTDSW 384
+ C+ W +A M R+ LN +Y +GG +V VE YDP T++W
Sbjct: 470 VE--CYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAW 527
Query: 385 TPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIAS 436
V+ N G LY+VG N +++ YNP TD W+V++S
Sbjct: 528 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 579
Score = 54.7 bits (130), Expect = 2e-07
Identities = 34/114 (29%), Positives = 51/114 (44%), Gaps = 7/114 (6%)
Query: 280 YNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASW 339
YN+ W + + + G + LNN +Y GG G + +W
Sbjct: 473 YNATTNEWTYIAEMST-RRSGAGVGVLNNLLYAVGGHDGPLV----RKSVEVYDPTTNAW 527
Query: 340 KPVAPMLKPRTNHASAALNGEIYVIGGT--TLDVVEVESYDPYTDSWTPVSPAL 391
+ VA M R N A+NG +YV+GG + ++ VE Y+P TD WT VS +
Sbjct: 528 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCM 581
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 236 bits (601), Expect = 5e-62
Identities = 160/551 (29%), Positives = 258/551 (46%), Gaps = 54/551 (9%)
Query: 5 LQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPA 64
+ LRSQ L DVT++ E+ HR +LA SPYFHAMF G+ +ES + RV +++V+
Sbjct: 46 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 105
Query: 65 VVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFG 124
+ L+D+VYT + +T+ NV+ L A L V+K C +L+ QL NCLGI F
Sbjct: 106 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 165
Query: 125 EQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMR 184
+ + KA + ++F V +EFL L E++ + ++ D L + E+ EA++
Sbjct: 166 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 225
Query: 185 WVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLA 244
WV HD R + L+ V L +PR + Q + E L++ S AC+ L + L
Sbjct: 226 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 285
Query: 245 LQQK---------------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMA 289
+Q+ L +++VVVGGQA + + Y+ K +RW
Sbjct: 286 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQA----------PKAIRSVECYDFKEERWHQ 335
Query: 290 LPDFPDYHKWGFSLAALNNNIYVTGGSRGT----KTDTWSTTQAWCFPLKEASWKPVAPM 345
+ + P + + + ++ GG G+ D++ P+K+ W VA M
Sbjct: 336 VAELPS-RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYD-------PVKD-QWTSVANM 386
Query: 346 LKPRTNHASAALNGEIYVIGG--TTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCR 403
R+ +A LNG +Y +GG + + VE+Y+ ++ W V+P S+
Sbjct: 387 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 446
Query: 404 GRLYLVG--SSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN 461
G LY VG A + ++CYN T+ W+ IA + S L+ LY +G +
Sbjct: 447 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE--MSTRRSGAGVGVLNNLLYAVGGH 504
Query: 462 -----TKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHV-EM 515
K V VYDP N W++V + N + + LYV GG +G ++ +
Sbjct: 505 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD----DGSCNLASV 560
Query: 516 EAYDTVRDTWT 526
E Y+ D WT
Sbjct: 561 EYYNPTTDKWT 571
Score = 76.6 bits (187), Expect = 5e-14
Identities = 47/172 (27%), Positives = 74/172 (43%), Gaps = 5/172 (2%)
Query: 267 GEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWST 326
G + + GL + YN K+ W + + + + + +Y GG G ST
Sbjct: 407 GFDGSTGLSSVEAYNIKSNEWFHVAPM-NTRRSSVGVGVVGGLLYAVGGYDGASRQCLST 465
Query: 327 TQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTTLDVVE--VESYDPYTDSW 384
+ C+ W +A M R+ LN +Y +GG +V VE YDP T++W
Sbjct: 466 VE--CYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAW 523
Query: 385 TPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIAS 436
V+ N G LY+VG N +++ YNP TD W+V++S
Sbjct: 524 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 575
Score = 54.7 bits (130), Expect = 2e-07
Identities = 34/114 (29%), Positives = 51/114 (44%), Gaps = 7/114 (6%)
Query: 280 YNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASW 339
YN+ W + + + G + LNN +Y GG G + +W
Sbjct: 469 YNATTNEWTYIAEMST-RRSGAGVGVLNNLLYAVGGHDGPLV----RKSVEVYDPTTNAW 523
Query: 340 KPVAPMLKPRTNHASAALNGEIYVIGGT--TLDVVEVESYDPYTDSWTPVSPAL 391
+ VA M R N A+NG +YV+GG + ++ VE Y+P TD WT VS +
Sbjct: 524 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCM 577
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 232 bits (591), Expect = 8e-61
Identities = 155/551 (28%), Positives = 259/551 (47%), Gaps = 54/551 (9%)
Query: 5 LQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPA 64
+ LRS+ L DV ++ E+ HR +LA SPYF AMF GD +ES + ++E++DV+
Sbjct: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99
Query: 65 VVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFG 124
+ +L+D++YT + +T+ NV+ L A+ L V++ C +LQ QL NCLGI F
Sbjct: 100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFA 159
Query: 125 EQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMR 184
+ + +A A+ ++F V +EFL L +++ + ++ D L V E+ EA++
Sbjct: 160 DVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
Query: 185 WVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLA 244
W+ ++ + R H+ +L+ V L +PR + Q + E LI+ + C+ L + L
Sbjct: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLP 279
Query: 245 LQQK---------------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMA 289
L Q+ L +V++VVGGQA + + Y+ + RW
Sbjct: 280 LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQA----------PKAIRSVECYDFEEDRWDQ 329
Query: 290 LPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPR 349
+ + P + + + ++Y GG G + + + W +A M + R
Sbjct: 330 IAELPS-RRCRAGVVFMAGHVYAVGGFNG----SLRVRTVDVYDGVKDQWTSIASMQERR 384
Query: 350 TNHASAALNGEIYVIGG--TTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLY 407
+ +A LN +Y +GG + + VE+Y T+ W V+P S+ G+LY
Sbjct: 385 STLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLY 444
Query: 408 LVGSSACKYNALALQC------YNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN 461
VG Y+ + QC YNP T+ W +A + S L G+LY G +
Sbjct: 445 AVGG----YDGASRQCLSTVEQYNPATNEWIYVAD--MSTRRSGAGVGVLSGQLYATGGH 498
Query: 462 -----TKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHV-EM 515
K V VYDPG N W++V + N + + LYV GG +G ++ +
Sbjct: 499 DGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGD----DGSCNLASV 554
Query: 516 EAYDTVRDTWT 526
E Y+ V D WT
Sbjct: 555 EYYNPVTDKWT 565
Score = 70.9 bits (172), Expect = 3e-12
Identities = 51/186 (27%), Positives = 79/186 (42%), Gaps = 10/186 (5%)
Query: 267 GEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWST 326
G + + GL + Y+ K W + + + + + +Y GG G ST
Sbjct: 401 GFDGSTGLASVEAYSYKTNEWFFVAPM-NTRRSSVGVGVVEGKLYAVGGYDGASRQCLST 459
Query: 327 TQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTTLDVVE--VESYDPYTDSW 384
+ + E W VA M R+ L+G++Y GG +V VE YDP T++W
Sbjct: 460 VEQYNPATNE--WIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTW 517
Query: 385 TPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLS 444
V+ N G LY+VG N +++ YNPVTD W++ LP +S
Sbjct: 518 KQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTL-----LPTNMS 572
Query: 445 SPRCAA 450
+ R A
Sbjct: 573 TGRSYA 578
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 229 bits (583), Expect = 7e-60
Identities = 164/580 (28%), Positives = 268/580 (46%), Gaps = 57/580 (9%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVEL-R 59
+L L LR Q DV L G R PCHR +LA S YF AMF+G ES + V
Sbjct: 32 VLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDN 91
Query: 60 DVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLG 119
+ P V+ L+D+ Y+ R+ I + N E+L L F ++ C +L++ L NCLG
Sbjct: 92 SIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLG 151
Query: 120 ICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRL 179
+ + + +W NF+ + + ++FLQLP++ +V L+ + L+ + E+
Sbjct: 152 MLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVY 211
Query: 180 EALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLI----------QESEA 229
E+ + W+ +D + R +LPELL V L +P + + +A E LI +E+
Sbjct: 212 ESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIR 271
Query: 230 CRAALSQGHDGAPLAL---QQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKR 286
C+ + Q +DG +L +K L ++GGQ ++ + KAK
Sbjct: 272 CKLKILQ-NDGVVTSLCARPRKTGHALFLLGGQTFMCDK-----------LYLVDQKAKE 319
Query: 287 WMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPML 346
+ D P K FS A+ +Y+TGG RG++ + W + W APML
Sbjct: 320 IIPKADIPSPRK-EFSACAIGCKVYITGG-RGSENGV--SKDVWVYDTLHEEWSKAAPML 375
Query: 347 KPRTNHASAALNGEIYVIGGTT-----------LDVVEVESYDPYTDSWTPVSPALKYVS 395
R H SA L +YV+GG T + + +VE YDP + WT V+P + VS
Sbjct: 376 VARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVS 435
Query: 396 NFSAAGCRGRLYLVGSSACKYNAL-ALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGE 454
N + + +L+ G ++ ++ L +QCY+ + W+V A+ P+ A L +
Sbjct: 436 NAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPAT--CPQPWRYTAAAVLGNQ 493
Query: 455 LYLIGDNTK----KVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGD 510
++++G +T+ Y ++ W KV + + V G+ LYV GG + G++
Sbjct: 494 IFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGG-YFGIQ-- 550
Query: 511 YHVEMEAYDTVRDTWTRHGALPRLWLYHGASTVFLDVSKW 550
++ YD D W +P Y T F VS W
Sbjct: 551 RCKTLDCYDPTLDVWNSITTVP----YSLIPTAF--VSTW 584
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 226 bits (577), Expect = 3e-59
Identities = 154/552 (27%), Positives = 245/552 (44%), Gaps = 27/552 (4%)
Query: 2 LDGLQRLRSQPKLADVTLLV-GGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
LD + D+TL G CHR +LA S YF AMF D E F +++L
Sbjct: 23 LDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSG 82
Query: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
+ ++ LV++ YT ++ IT+ NV++L A L F SV+K C R+L + LD NC+G+
Sbjct: 83 IHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGM 142
Query: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
F E + ++ L F+ V +++EFL++ E+ + L+ L V E++ +E
Sbjct: 143 HSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIE 202
Query: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDG 240
+++W HD + R L LLS +++D P L + R+ + +
Sbjct: 203 PVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRSCLLTENKIRSLIYNALNP 262
Query: 241 APLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWG 300
+ Q+ + ++GG L ++ W+ + PDY +
Sbjct: 263 MHKEISQRSTATMYIIGGYYWHP----------LSEVHIWDPLTNVWIQGAEIPDYTRES 312
Query: 301 FSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGE 360
+ + L NIYVTGG R + T W + + W PML R H + L G
Sbjct: 313 YGVTCLGPNIYVTGGYRTDNIEALDT--VWIYNSESDEWTEGLPMLNARYYHCAVTLGGC 370
Query: 361 IYVIGG--TTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGS-----SA 413
+Y +GG E E YDP + W P++ +K V N +A +Y++G +
Sbjct: 371 VYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGS 430
Query: 414 CKYNALALQCYNPVTDAWSVIASPFLPKY-LSSPRCAALHGELYLIGDNTKKVYVYDPGA 472
C Y+ +Q YN + WS+I S P+Y L S +LYL+G T YDP
Sbjct: 431 CTYD--KVQSYNSDINEWSLITSSPHPEYGLCS---VPFENKLYLVGGQTTITECYDPEQ 485
Query: 473 NLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHGALP 532
N W+++ V + +YVTGG + +G Y +E YD + W G LP
Sbjct: 486 NEWREIAPMMERRMECGAVIMNGCIYVTGG-YSYSKGTYLQSIEKYDPDLNKWEIVGNLP 544
Query: 533 RLWLYHGASTVF 544
HG V+
Sbjct: 545 SAMRSHGCVCVY 556
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 225 bits (574), Expect = 7e-59
Identities = 166/568 (29%), Positives = 267/568 (47%), Gaps = 39/568 (6%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVE--- 57
ML L + R D+ ++V GRE H+ +LA S YF + +S E
Sbjct: 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLE 374
Query: 58 --LRDVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAA 115
L +++ V+ L++FVYTG L I N + L A++ F + KVC +L++QL A+
Sbjct: 375 LVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
Query: 116 NCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPE 175
NCLG+ E + A AF + F VA ++E L + ++ + ++ D L + E
Sbjct: 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAE 494
Query: 176 QSRLEALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALS 235
+ E +++W++ DP R + ELL++V L + + ++ +E LI+ SEACR ++
Sbjct: 495 ELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVN 554
Query: 236 QG--HDGAPLALQQK------------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYN 281
+ + P A Q+ + EV+V+VGG+ + L +N
Sbjct: 555 EAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMV-----GMTQRSLVAVTCWN 609
Query: 282 SKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKP 341
+ +W L P Y + FS+ + +NIY++GG T WC+ +W
Sbjct: 610 PQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVT----LADVWCYMSLLDNWNL 665
Query: 342 VAPMLKPRTNHASAALNGEIYVIGGTTL--DVVEVESYDPYTDSWTPVSPALKYVSNFSA 399
V+ M PR H S +G+IY +GG + +V VE YD T+ W V+P K V + +A
Sbjct: 666 VSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAA 725
Query: 400 AGCRGRLYLVGS-SACKYNALALQCYNPVTDAWSVIASPFLP-KYLSSPRCAALHGELYL 457
C G++Y+ G + A LQ Y P T+ WS I SP + KY + L+G +++
Sbjct: 726 TVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPA---VTLNGFVFI 782
Query: 458 IGD-NTKKVYVYDP-GANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEM 515
+G + +YDP N+ HS A+V L +Y TGG EG M
Sbjct: 783 LGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVV-LDGKIYATGG-IVSSEGPALGNM 840
Query: 516 EAYDTVRDTWTRHGALPRLWLYHGASTV 543
EAY+ +TWT +P HG +
Sbjct: 841 EAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 225 bits (574), Expect = 7e-59
Identities = 166/568 (29%), Positives = 267/568 (47%), Gaps = 39/568 (6%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVE--- 57
ML L + R D+ ++V GRE H+ +LA S YF + +S E
Sbjct: 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLE 374
Query: 58 --LRDVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAA 115
L +++ V+ L++FVYTG L I N + L A++ F + KVC +L++QL A+
Sbjct: 375 LVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
Query: 116 NCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPE 175
NCLG+ E + A AF + F VA ++E L + ++ + ++ D L + E
Sbjct: 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAE 494
Query: 176 QSRLEALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALS 235
+ E +++W++ DP R + ELL++V L + + ++ +E LI+ SEACR ++
Sbjct: 495 ELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVN 554
Query: 236 QG--HDGAPLALQQK------------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYN 281
+ + P A Q+ + EV+V+VGG+ + L +N
Sbjct: 555 EAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMV-----GMTQRSLVAVTCWN 609
Query: 282 SKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKP 341
+ +W L P Y + FS+ + +NIY++GG T WC+ +W
Sbjct: 610 PQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVT----LADVWCYMSLLDNWNL 665
Query: 342 VAPMLKPRTNHASAALNGEIYVIGGTTL--DVVEVESYDPYTDSWTPVSPALKYVSNFSA 399
V+ M PR H S +G+IY +GG + +V VE YD T+ W V+P K V + +A
Sbjct: 666 VSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAA 725
Query: 400 AGCRGRLYLVGS-SACKYNALALQCYNPVTDAWSVIASPFLP-KYLSSPRCAALHGELYL 457
C G++Y+ G + A LQ Y P T+ WS I SP + KY + L+G +++
Sbjct: 726 TVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPA---VTLNGFVFI 782
Query: 458 IGD-NTKKVYVYDP-GANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEM 515
+G + +YDP N+ HS A+V L +Y TGG EG M
Sbjct: 783 LGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVV-LDGKIYATGG-IVSSEGPALGNM 840
Query: 516 EAYDTVRDTWTRHGALPRLWLYHGASTV 543
EAY+ +TWT +P HG +
Sbjct: 841 EAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 222 bits (566), Expect = 6e-58
Identities = 164/566 (28%), Positives = 254/566 (44%), Gaps = 37/566 (6%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
+L L LR L DV++ G RE+PCHR +LA SSPYF AMF F E A+V+L+
Sbjct: 20 LLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKG 79
Query: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
++P + Q+V +VYTG I NV + A+ L FP + + C YLQ QL +NCLG+
Sbjct: 80 IDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGM 139
Query: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
E + KA +F VA + +L L L D L E+ E
Sbjct: 140 IRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGEEEKVFE 198
Query: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGH-- 238
ALM W++HD QAR ++ EL V L + +A++ L+Q S AC+ L
Sbjct: 199 ALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQ 258
Query: 239 ---------DGAPLAL----QQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAK 285
L L + ++ L+++GG+ ++ + Y+ +
Sbjct: 259 MFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRD--------VLLYSKQTG 310
Query: 286 RWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPM 345
+W +L P + S L+ +IYV GG + + + + F LK W+ PM
Sbjct: 311 QWQSLAKLPT-RLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPM 369
Query: 346 LKPRTNHASAALNGEIYVIGGTTLD---VVEVESYDPYTDSWTPVSPALKYVSNFSAAGC 402
L R +H S A I+ IGG + +E YD + W ++ V + + A
Sbjct: 370 LVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVK 429
Query: 403 RGRLYLVGSSACKYNALAL-QCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN 461
RLYL G N + L Q Y+ ++W + + + K + +P L + ++G
Sbjct: 430 DQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMI-KNVCAP-AVVLGERIVIVGGY 487
Query: 462 TKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVE----MEA 517
T+++ YDP +N + K + +G+ LYVTGGR + D ++E +
Sbjct: 488 TRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGR--RLTTDCNIEDSASFDC 545
Query: 518 YDTVRDTWTRHGALPRLWLYHGASTV 543
YD DTWT G LP H T+
Sbjct: 546 YDPETDTWTSQGQLPHKLFDHACLTL 571
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 217 bits (553), Expect = 2e-56
Identities = 159/566 (28%), Positives = 257/566 (45%), Gaps = 69/566 (12%)
Query: 2 LDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDV 61
L+ + LR +L DV L+VG +++ HR +L+ SPYF AMF G+ AES V +RD+
Sbjct: 55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI 114
Query: 62 EPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGIC 121
+ + L+DF YT ++T+ +GNV+ L A L +Q+ C +L++QLD +NCLGI
Sbjct: 115 DERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIR 174
Query: 122 EFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEA 181
F + + A F + NF+ V +EF+ LP +L+ ++ D L V+ E+ A
Sbjct: 175 AFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNA 234
Query: 182 LMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGA 241
+M WV++ Q R LP++L V L + + + S+PLI+ E CR + + +
Sbjct: 235 VMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYL 294
Query: 242 PLALQQKL--------------EEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRW 287
L ++ L EVL VGG + + + Y+ + W
Sbjct: 295 LLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGD---------AISSVERYDPQTNEW 345
Query: 288 MALPDFPDYHKWGFSLAALNNNIYVTGGSRGT-----------KTDTWSTTQAWCFPLKE 336
+ + G ++ L++ +Y GG G+ KT+ WS+
Sbjct: 346 RMVASM-SKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSS---------- 394
Query: 337 ASWKPVAPMLKPRTNHASAALNGEIYVIGG----TTLDVVEVESYDPYTDSWTPVSPALK 392
VAP RT+ A L G +Y +GG + L++ VE YDP + WT V+
Sbjct: 395 ----DVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNI--VERYDPKENKWTRVASMST 448
Query: 393 YVSNFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIA-SPFLPKYLSSPRCAAL 451
+ A G LY VG S ++ YNP + W IA K+L CA
Sbjct: 449 RRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLG---CAVY 505
Query: 452 HGELYLIG--DNTKKVYV---YDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQG 506
+Y +G D+T ++ Y+P N W V + S L + L G G
Sbjct: 506 QDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVG----G 561
Query: 507 MEGDYHVE-MEAYDTVRDTWTRHGAL 531
+G +++ +E +D +TW +G +
Sbjct: 562 FDGTTYLKTIEVFDPDANTWRLYGGM 587
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 217 bits (552), Expect = 3e-56
Identities = 161/575 (28%), Positives = 256/575 (44%), Gaps = 44/575 (7%)
Query: 5 LQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPA 64
+ R+R + L D+ L V +E+ H+ +LA SPYFHAMF + +ES V L D++P
Sbjct: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
Query: 65 VVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFG 124
+ QLV F YT + + +GNV+ L A+ L V+ C ++L QLD +NCLGI F
Sbjct: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
Query: 125 EQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMR 184
+ + A ++ ++F VA+ +EF+ LP ++++ ++ D L V E+ A++
Sbjct: 202 DAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
Query: 185 WVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAAL---------- 234
WV+HD AR H+P L+ V L + R + + +E L++ C+ L
Sbjct: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP 321
Query: 235 -SQGHDGAPLALQQKLE---EVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMAL 290
+G G ++ E VL VGG +L G+ Y+++ RW +
Sbjct: 322 EQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIH---------GDCEAYDTRTDRWHVV 372
Query: 291 PDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRT 350
+ +AA+ N +Y GG G T +T +++ P+ +W+P M R+
Sbjct: 373 ASM-STRRARVGVAAVGNRLYAVGGYDG--TSDLATVESY-DPVTN-TWQPEVSMGTRRS 427
Query: 351 NHASAALNGEIYVIGG--TTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYL 408
AAL+G +Y GG + E YDP T +WT V+ A G LY
Sbjct: 428 CLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYA 487
Query: 409 VGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN-----TK 463
VG + ++ Y P + WS +AS + SS A L G LY+ G N
Sbjct: 488 VGGYDSSSHLATVEKYEPQVNVWSPVASMLSRR--SSAGVAVLEGALYVAGGNDGTSCLN 545
Query: 464 KVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHV-EMEAYDTVR 522
V Y P A W+ V + LV + LY GG +G + +E Y+
Sbjct: 546 SVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGN----DGSSSLNSIEKYNPRT 601
Query: 523 DTWTRHGALPRLWLYHGASTVFLDVSKWTQPSGPT 557
+ W + L++ + PS PT
Sbjct: 602 NKWVAASCM--FTRRSSVGVAVLELLNFPPPSSPT 634
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 215 bits (548), Expect = 8e-56
Identities = 148/564 (26%), Positives = 251/564 (44%), Gaps = 42/564 (7%)
Query: 3 DGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVE 62
+GL+ LR + L DV L V +E CHR +LA +S YF AMF D E + R+ ++ V+
Sbjct: 60 NGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVD 119
Query: 63 PAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICE 122
+ L+D+ YT + IT+ NV+ + A F + C +L + L+ NC+GI
Sbjct: 120 AETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILR 179
Query: 123 FGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEAL 182
+ L + + +++ +NF + +EFL LP + L L D L V E E +
Sbjct: 180 LADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETV 239
Query: 183 MRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGH---- 238
M WVRH P R LP +L V L + + + ++PLI++ L +
Sbjct: 240 MSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL 299
Query: 239 -------DGAPLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALP 291
+ + + EV +++GG +E E + + + +
Sbjct: 300 SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAE--------VTCLDPLRRSRLEVA 351
Query: 292 DFP--------DYHKW-GFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPV 342
P + KW F+ L N +Y++GG + T+ D W + W +
Sbjct: 352 KLPLTEHELESENKKWVEFACVTLKNEVYISGG-KETQHDVWK------YNSSINKWIQI 404
Query: 343 APMLKPRTNHASAALNGEIYVIGG--TTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAA 400
+ R H L G++YVIGG + VE+YDP+ + W+ +P L +VS+F+A
Sbjct: 405 EYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAAT 464
Query: 401 GCRGRLYLVGSSA-CKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIG 459
+ +LY++G K QCY+P T+ WS+ A+ +P + +Y++G
Sbjct: 465 SHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAA--MPVEAKCINAVSFRDRIYVVG 522
Query: 460 DNTKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYD 519
+ +Y Y P + W V + + P + LY+TGGR + + + + +D
Sbjct: 523 GAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDE--KNEVIATVLCWD 580
Query: 520 TVRDTWTRHGALPRLWLYHGASTV 543
T LPR +HG+ T+
Sbjct: 581 PEAQKLTEECVLPRGVSHHGSVTI 604
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 209 bits (533), Expect = 4e-54
Identities = 151/534 (28%), Positives = 239/534 (44%), Gaps = 33/534 (6%)
Query: 13 KLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAVVGQLVDF 72
+L DV L+ G R +P HR +L+ S YF AMF D E+ +++ VEP + L+ +
Sbjct: 172 QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQY 231
Query: 73 VYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGEQQGLLGV 132
YTGRL + + N+E L TA L V + C ++L +QL +NCLGI F + QG +
Sbjct: 232 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDL 291
Query: 133 AAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMRWVRHDPQA 192
A + E+F V R EF+ LP + LA D + + E++ L AL+ WVRHD +
Sbjct: 292 HKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQ 351
Query: 193 RAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQG------HDGAPLALQ 246
R L +LL+ + L + P + + L ++ C+ + + + P+
Sbjct: 352 RRKDLSKLLAYIRLPLL-APQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQS 410
Query: 247 QKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAAL 306
+ + VG G + T G + Y+ + W + + + + F +A L
Sbjct: 411 PRTKPRKSTVGTLF---AVGGMDSTKGATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVL 466
Query: 307 NNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGG 366
++ +YV GG G KT C+ K +W + PM R A L G +Y +GG
Sbjct: 467 DDKLYVVGGRDGLKT----LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG 522
Query: 367 TT--LDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCY 424
+ VE +DP W V+ S A G+LY VG +++C+
Sbjct: 523 HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECF 582
Query: 425 NPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN-----------TKKVYVYDPGAN 473
+P T+ W++ A + K +G LY IG + + V YDP +
Sbjct: 583 DPHTNKWTLCAQ--MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTD 640
Query: 474 LWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTR 527
+W V S + + LGD LY GG + G Y +EAYD + WT+
Sbjct: 641 MWTAVASMSISRDAVGVCLLGDKLYAVGG-YDGQA--YLNTVEAYDPQTNEWTQ 691
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/247 (24%), Positives = 88/247 (35%), Gaps = 79/247 (31%)
Query: 249 LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNN 308
L++ L VVGG+ + L YN K K W +P H+ G +A L
Sbjct: 466 LDDKLYVVGGR---------DGLKTLNTVECYNPKTKTWSVMPPMST-HRHGLGVAVLEG 515
Query: 309 NIYVTGGSRGTKTDTWS---TTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVI- 364
+Y GG G WS T + W ++ W VA M PR+ A L+G++Y +
Sbjct: 516 PMYAVGGHDG-----WSYLNTVERWDPQARQ--WNFVATMSTPRSTVGVAVLSGKLYAVG 568
Query: 365 ---GGTTLDVVE------------------------------------------------ 373
G + L VE
Sbjct: 569 GRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 628
Query: 374 ---VESYDPYTDSWTPVSPALKYVSNFSAAGCR--GRLYLVGSSACKYNALALQCYNPVT 428
VE YDP TD WT V A +S + C +LY VG + ++ Y+P T
Sbjct: 629 SDCVERYDPKTDMWTAV--ASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQT 686
Query: 429 DAWSVIA 435
+ W+ +A
Sbjct: 687 NEWTQVA 693
Score = 37.0 bits (84), Expect = 0.048
Identities = 26/94 (27%), Positives = 37/94 (39%), Gaps = 4/94 (4%)
Query: 300 GFSLAALNNNIYVTGGSRGTKTDTWSTTQAWC--FPLKEASWKPVAPMLKPRTNHASAAL 357
G + N +Y GG ++ S + K W VA M R L
Sbjct: 601 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 660
Query: 358 NGEIYVIGGTTLDVV--EVESYDPYTDSWTPVSP 389
++Y +GG VE+YDP T+ WT V+P
Sbjct: 661 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP 694
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 209 bits (533), Expect = 4e-54
Identities = 151/534 (28%), Positives = 239/534 (44%), Gaps = 33/534 (6%)
Query: 13 KLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAVVGQLVDF 72
+L DV L+ G R +P HR +L+ S YF AMF D E+ +++ VEP + L+ +
Sbjct: 218 QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQY 277
Query: 73 VYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGEQQGLLGV 132
YTGRL + + N+E L TA L V + C ++L +QL +NCLGI F + QG +
Sbjct: 278 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDL 337
Query: 133 AAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMRWVRHDPQA 192
A + E+F V R EF+ LP + LA D + + E++ L AL+ WVRHD +
Sbjct: 338 HKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQ 397
Query: 193 RAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQG------HDGAPLALQ 246
R L +LL+ + L + P + + L ++ C+ + + + P+
Sbjct: 398 RRKDLSKLLAYIRLPLL-APQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQS 456
Query: 247 QKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAAL 306
+ + VG G + T G + Y+ + W + + + + F +A L
Sbjct: 457 PRTKPRKSTVGTLF---AVGGMDSTKGATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVL 512
Query: 307 NNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGG 366
++ +YV GG G KT C+ K +W + PM R A L G +Y +GG
Sbjct: 513 DDKLYVVGGRDGLKT----LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG 568
Query: 367 TT--LDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCY 424
+ VE +DP W V+ S A G+LY VG +++C+
Sbjct: 569 HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECF 628
Query: 425 NPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN-----------TKKVYVYDPGAN 473
+P T+ W++ A + K +G LY IG + + V YDP +
Sbjct: 629 DPHTNKWTLCAQ--MSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTD 686
Query: 474 LWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTR 527
+W V S + + LGD LY GG + G Y +EAYD + WT+
Sbjct: 687 MWTAVASMSISRDAVGVCLLGDKLYAVGG-YDGQA--YLNTVEAYDPQTNEWTQ 737
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/247 (24%), Positives = 88/247 (35%), Gaps = 79/247 (31%)
Query: 249 LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNN 308
L++ L VVGG+ + L YN K K W +P H+ G +A L
Sbjct: 512 LDDKLYVVGGR---------DGLKTLNTVECYNPKTKTWSVMPPMST-HRHGLGVAVLEG 561
Query: 309 NIYVTGGSRGTKTDTWS---TTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVI- 364
+Y GG G WS T + W ++ W VA M PR+ A L+G++Y +
Sbjct: 562 PMYAVGGHDG-----WSYLNTVERWDPQARQ--WNFVATMSTPRSTVGVAVLSGKLYAVG 614
Query: 365 ---GGTTLDVVE------------------------------------------------ 373
G + L VE
Sbjct: 615 GRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 674
Query: 374 ---VESYDPYTDSWTPVSPALKYVSNFSAAGCR--GRLYLVGSSACKYNALALQCYNPVT 428
VE YDP TD WT V A +S + C +LY VG + ++ Y+P T
Sbjct: 675 SDCVERYDPKTDMWTAV--ASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQT 732
Query: 429 DAWSVIA 435
+ W+ +A
Sbjct: 733 NEWTQVA 739
Score = 37.0 bits (84), Expect = 0.048
Identities = 26/94 (27%), Positives = 37/94 (39%), Gaps = 4/94 (4%)
Query: 300 GFSLAALNNNIYVTGGSRGTKTDTWSTTQAWC--FPLKEASWKPVAPMLKPRTNHASAAL 357
G + N +Y GG ++ S + K W VA M R L
Sbjct: 647 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 706
Query: 358 NGEIYVIGGTTLDVV--EVESYDPYTDSWTPVSP 389
++Y +GG VE+YDP T+ WT V+P
Sbjct: 707 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP 740
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 208 bits (529), Expect = 1e-53
Identities = 156/536 (29%), Positives = 232/536 (43%), Gaps = 77/536 (14%)
Query: 11 QPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAVVGQLV 70
Q +L DV L+VG R++P HR +L+ S YF AMF D E+ +++ ++P + LV
Sbjct: 208 QQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLV 267
Query: 71 DFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGEQQGLL 130
F YTG L + + +E L A L P V +VC +L + L +NCLGI F + QG +
Sbjct: 268 QFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCI 327
Query: 131 GVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMRWVRHDP 190
+ A ++ EN V R EFL LP E L LA D + V E++ ALM WV++D
Sbjct: 328 ELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDM 387
Query: 191 QARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLALQQKLE 250
Q+R L LL+ + L +P P + L + L + C+ + + L ++ L
Sbjct: 388 QSRCNDLSMLLAFIRLPLLP-PQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLM 446
Query: 251 E------------VLVVVGGQ-------ALEEEE-------------------------- 265
+ L VGG +E+ +
Sbjct: 447 QSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDD 506
Query: 266 -----AGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTK 320
G + L YN K K W LP H+ G + L IY GG
Sbjct: 507 KLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPM-STHRHGLGVTVLEGPIYAVGGH---- 561
Query: 321 TDTWS---TTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGT--TLDVVEVE 375
D WS T + W + W VA M R+ AALNG++Y +GG + + +E
Sbjct: 562 -DGWSYLNTVERW--DPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSME 618
Query: 376 SYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVG------SSACKYNALALQCYNPVTD 429
YDP+T+ W +P K A C G LY VG S+ C ++ Y+P TD
Sbjct: 619 YYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTD 678
Query: 430 AWSVIASPFLPKYLSSPRCAALHGELYLIGDNTKKVYV-----YDPGANLWQKVQS 480
W+++A +P+ + L LY +G + Y+ YDP N W ++ S
Sbjct: 679 TWTMVAPLSMPR--DAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMAS 732
>gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 201 bits (510), Expect = 2e-51
Identities = 149/563 (26%), Positives = 253/563 (44%), Gaps = 43/563 (7%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
+L LQ R Q D +++ +PCHR +LA S +F AMF + E V + +
Sbjct: 38 ILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITN 97
Query: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
+ V +D+ YTG+ IT NVE + ++ L + K C +L + ++ NCL +
Sbjct: 98 LSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQL 157
Query: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
+ G + A F++ +F + + +FL++ L CL D L V E+ L+
Sbjct: 158 LSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLK 217
Query: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALS----- 235
++ W +H+ ++R +LP L+ V L + +Q L +E + +S C +
Sbjct: 218 VVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKC 277
Query: 236 -QGHDGA-PLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAF-YNSKAKRWMALPD 292
QG G P A E+ + + + EE GE + F YN K+ W LP
Sbjct: 278 VQGSGGLFPDARPSTTEKYIFI-----HKTEENGE------NQYTFCYNIKSDSWKILPQ 326
Query: 293 FPDYHKWGFSLAALNNNIYVTGGSRGTKTDTW----------STTQAWCFPLKEASWKPV 342
G SL++ I++TGG +G T +T Q WC+ + + V
Sbjct: 327 SHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLV 386
Query: 343 APMLKPRTNHASAALNGEIYVIGGTT------LDVVEVESYDPYTDSWTPVSPALKYVSN 396
+ M PRT H S ++VIGG T +++VESY+P + W VSP + +
Sbjct: 387 STMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYY 446
Query: 397 FSAAGCRGRLYLVGSSACKYNAL--ALQC---YNPVTDAWSVIASPFLPKYLSS-PRCAA 450
A+ C+ +Y++GS +A +L C YN TD WS + + F + ++ +
Sbjct: 447 PEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVP 506
Query: 451 LHGELYLIGDNTKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGD 510
++ LY+ +T KVY + P +W+ S N + + D +Y+ GG + +
Sbjct: 507 VNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDY--APDE 564
Query: 511 YHVEMEAYDTVRDTWTRHGALPR 533
E++ Y + R W +PR
Sbjct: 565 ITDEVQVYHSNRSEWEEVSPMPR 587
Score = 32.7 bits (73), Expect = 0.90
Identities = 32/140 (22%), Positives = 55/140 (39%), Gaps = 21/140 (15%)
Query: 423 CYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIG-------------------DNTK 463
CYN +D+W ++ L L ++ +++L G D T
Sbjct: 313 CYNIKSDSWKILPQSHLID-LPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATD 371
Query: 464 KVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHV-EMEAYDTVR 522
+ + Y P N + V + + V D L+V GG+ +G + ++E+Y+ +
Sbjct: 372 QTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLS 431
Query: 523 DTWTRHGALPRLWLYHGAST 542
W LPR Y AST
Sbjct: 432 KEWISVSPLPRGIYYPEAST 451
>gi|38327516 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 201 bits (510), Expect = 2e-51
Identities = 149/563 (26%), Positives = 253/563 (44%), Gaps = 43/563 (7%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
+L LQ R Q D +++ +PCHR +LA S +F AMF + E V + +
Sbjct: 38 ILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITN 97
Query: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
+ V +D+ YTG+ IT NVE + ++ L + K C +L + ++ NCL +
Sbjct: 98 LSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQL 157
Query: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
+ G + A F++ +F + + +FL++ L CL D L V E+ L+
Sbjct: 158 LSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLK 217
Query: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALS----- 235
++ W +H+ ++R +LP L+ V L + +Q L +E + +S C +
Sbjct: 218 VVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFDIIMDAIKC 277
Query: 236 -QGHDGA-PLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAF-YNSKAKRWMALPD 292
QG G P A E+ + + + EE GE + F YN K+ W LP
Sbjct: 278 VQGSGGLFPDARPSTTEKYIFI-----HKTEENGE------NQYTFCYNIKSDSWKILPQ 326
Query: 293 FPDYHKWGFSLAALNNNIYVTGGSRGTKTDTW----------STTQAWCFPLKEASWKPV 342
G SL++ I++TGG +G T +T Q WC+ + + V
Sbjct: 327 SHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYCPVKNDFFLV 386
Query: 343 APMLKPRTNHASAALNGEIYVIGGTT------LDVVEVESYDPYTDSWTPVSPALKYVSN 396
+ M PRT H S ++VIGG T +++VESY+P + W VSP + +
Sbjct: 387 STMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWISVSPLPRGIYY 446
Query: 397 FSAAGCRGRLYLVGSSACKYNAL--ALQC---YNPVTDAWSVIASPFLPKYLSS-PRCAA 450
A+ C+ +Y++GS +A +L C YN TD WS + + F + ++ +
Sbjct: 447 PEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVP 506
Query: 451 LHGELYLIGDNTKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGD 510
++ LY+ +T KVY + P +W+ S N + + D +Y+ GG + +
Sbjct: 507 VNCTLYICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDY--APDE 564
Query: 511 YHVEMEAYDTVRDTWTRHGALPR 533
E++ Y + R W +PR
Sbjct: 565 ITDEVQVYHSNRSEWEEVSPMPR 587
Score = 32.7 bits (73), Expect = 0.90
Identities = 32/140 (22%), Positives = 55/140 (39%), Gaps = 21/140 (15%)
Query: 423 CYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIG-------------------DNTK 463
CYN +D+W ++ L L ++ +++L G D T
Sbjct: 313 CYNIKSDSWKILPQSHLID-LPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATD 371
Query: 464 KVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHV-EMEAYDTVR 522
+ + Y P N + V + + V D L+V GG+ +G + ++E+Y+ +
Sbjct: 372 QTWCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLS 431
Query: 523 DTWTRHGALPRLWLYHGAST 542
W LPR Y AST
Sbjct: 432 KEWISVSPLPRGIYYPEAST 451
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 200 bits (509), Expect = 3e-51
Identities = 147/552 (26%), Positives = 246/552 (44%), Gaps = 46/552 (8%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
+L GL LR +L D+ L VG ++ H+ +LA SPYF AMF G+ +E ++ VE +
Sbjct: 21 LLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQC 80
Query: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
++ + +V++ YTG + I+Q VE+L A L V K C +L+ QLD NC+GI
Sbjct: 81 IDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGI 140
Query: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
F E G + A ++ +NFEAV + +EF +L L ++ D L V E++
Sbjct: 141 SRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFY 200
Query: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQ---- 236
AL W+++D Q R +L +LL+ V L + + +L + LI++ C+ L++
Sbjct: 201 ALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKY 260
Query: 237 --------GHDGAPLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWM 288
H + + +VL VGG++ L + Y + W+
Sbjct: 261 HFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKS--------GLFACLDSVEMYFPQNDSWI 312
Query: 289 ALPDFPDYHKWGFSLAALNNNIYVTGG----SRGTKTDTWSTTQAWCFPLKEASWKPVAP 344
L + ++ F + L+ +YV GG R T C+ +W +
Sbjct: 313 GLAPL-NIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
Query: 345 MLKPRTNHASAALNGEIYVIGGTTLD--VVEVESYDPYTDSWTPVSPALKYVSNFSAAGC 402
M + R+ L GE+Y +GG + VE Y P W PV+P S F+AA
Sbjct: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
Query: 403 RGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPR----CAALHGELYLI 458
G +Y +G + +++ Y+P D+W ++AS ++ R + G ++++
Sbjct: 432 DGMIYAIGGYG-PAHMNSVERYDPSKDSWEMVAS------MADKRIHFGVGVMLGFIFVV 484
Query: 459 G-----DNTKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHV 513
G + + YDP N W + + + LYV GG Y
Sbjct: 485 GGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGH---SGSSYLN 541
Query: 514 EMEAYDTVRDTW 525
++ YD + DTW
Sbjct: 542 TVQKYDPISDTW 553
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 197 bits (501), Expect = 2e-50
Identities = 152/546 (27%), Positives = 231/546 (42%), Gaps = 45/546 (8%)
Query: 5 LQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPA 64
++ + +L DV L+ G +P HR +L+ S YF AMF D E+ V + V+P
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 65 VVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFG 124
+ LV + YTG L + + +E+L A L V VC +L +QL +NCLGI FG
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 125 EQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMR 184
+ QG + A + E+F V + EFL LP + L D + V E++ ALM+
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 185 WVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLA 244
WV HD Q R L LLS + L +P + L S + E C+ L + L
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLE-CQKLLMEAMKYHLLP 410
Query: 245 LQQKLEE------------VLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPD 292
++ + + L VGG + G Y+ + W+ +
Sbjct: 411 ERRSMMQSPRTKPRKSTVGALYAVGGM---------DAMKGTTTIEKYDLRTNSWLHIGT 461
Query: 293 FPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNH 352
+ + F +A ++N +YV GG G KT CF W + PM R
Sbjct: 462 M-NGRRLQFGVAVIDNKLYVVGGRDGLKT----LNTVECFNPVGKIWTVMPPMSTHRHGL 516
Query: 353 ASAALNGEIYVIGGTT--LDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVG 410
A L G +Y +GG + VE +DP W V+ S +LY +G
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIG 576
Query: 411 SSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN--------- 461
+++ ++P T+ WS+ A + K A +G LY++G +
Sbjct: 577 GRDGSSCLKSMEYFDPHTNKWSLCAP--MSKRRGGVGVATYNGFLYVVGGHDAPASNHCS 634
Query: 462 --TKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYD 519
+ V YDP + W V + A+ PLGD LYV GG + G Y +E+YD
Sbjct: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG--HTYLNTVESYD 691
Query: 520 TVRDTW 525
R+ W
Sbjct: 692 AQRNEW 697
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 197 bits (501), Expect = 2e-50
Identities = 152/546 (27%), Positives = 231/546 (42%), Gaps = 45/546 (8%)
Query: 5 LQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPA 64
++ + +L DV L+ G +P HR +L+ S YF AMF D E+ V + V+P
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 65 VVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFG 124
+ LV + YTG L + + +E+L A L V VC +L +QL +NCLGI FG
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 125 EQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMR 184
+ QG + A + E+F V + EFL LP + L D + V E++ ALM+
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 185 WVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLA 244
WV HD Q R L LLS + L +P + L S + E C+ L + L
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLE-CQKLLMEAMKYHLLP 410
Query: 245 LQQKLEE------------VLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPD 292
++ + + L VGG + G Y+ + W+ +
Sbjct: 411 ERRSMMQSPRTKPRKSTVGALYAVGGM---------DAMKGTTTIEKYDLRTNSWLHIGT 461
Query: 293 FPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNH 352
+ + F +A ++N +YV GG G KT CF W + PM R
Sbjct: 462 M-NGRRLQFGVAVIDNKLYVVGGRDGLKT----LNTVECFNPVGKIWTVMPPMSTHRHGL 516
Query: 353 ASAALNGEIYVIGGTT--LDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVG 410
A L G +Y +GG + VE +DP W V+ S +LY +G
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIG 576
Query: 411 SSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN--------- 461
+++ ++P T+ WS+ A + K A +G LY++G +
Sbjct: 577 GRDGSSCLKSMEYFDPHTNKWSLCAP--MSKRRGGVGVATYNGFLYVVGGHDAPASNHCS 634
Query: 462 --TKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYD 519
+ V YDP + W V + A+ PLGD LYV GG + G Y +E+YD
Sbjct: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG--HTYLNTVESYD 691
Query: 520 TVRDTW 525
R+ W
Sbjct: 692 AQRNEW 697
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 194 bits (494), Expect = 1e-49
Identities = 146/533 (27%), Positives = 235/533 (44%), Gaps = 68/533 (12%)
Query: 5 LQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPA 64
++ +R Q KL DVTL +G + HR +LA S PYFHAMF D E + ++ ++P+
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 65 VVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFG 124
+ L++F Y G L I Q NV++L A+ L S++ C +L+++L NCLG+ +F
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 125 EQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMR 184
E + A +F+ ++F V+ +EFL LP E ++ ++ D L V+ E+ EA +
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
Query: 185 WVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLA 244
WVR+D + R +LPELLS + L + + + L++ CR + + D
Sbjct: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD----- 262
Query: 245 LQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLA 304
Y+ +R LP F + S+A
Sbjct: 263 -----------------------------------YHLMPERRPHLPAFRTRPRCCTSIA 287
Query: 305 ALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVI 364
L IY GG + D+ + + F W+ PM R+ A +NG +Y I
Sbjct: 288 GL---IYAVGG-LNSAGDSLNVVEV--FDPIANCWERCRPMTTARSRVGVAVVNGLLYAI 341
Query: 365 GG--TTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQ 422
GG L + VE+Y+P TD+WT V S G++Y+ G + +++
Sbjct: 342 GGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVE 401
Query: 423 CYNPVTDAWSVIASPFLPKYLSSPRCAA----LHGELYLIGDNT-----KKVYVYDPGAN 473
Y+P TD W+V+ S +SS R AA G +Y+ G + V Y+
Sbjct: 402 TYSPETDKWTVVTS------MSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTA 455
Query: 474 LWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEM-EAYDTVRDTW 525
W + LG ++V G G +G + + E Y +V D W
Sbjct: 456 TWHPAAGMLNKRCRHGAASLGSKMFVCG----GYDGSGFLSIAEMYSSVADQW 504
Score = 65.5 bits (158), Expect = 1e-10
Identities = 45/173 (26%), Positives = 76/173 (43%), Gaps = 11/173 (6%)
Query: 267 GEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWST 326
G + L + Y+ + +W + ++ + IYV+GG G + +S+
Sbjct: 390 GYDGNSSLSSVETYSPETDKWTVVTSMSS-NRSAAGVTVFEGRIYVSGGHDGLQI--FSS 446
Query: 327 TQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTT----LDVVEVESYDPYTD 382
+ + A+W P A ML R H +A+L +++V GG L + E+ Y D
Sbjct: 447 VEHYNH--HTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEM--YSSVAD 502
Query: 383 SWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIA 435
W + P S S GRLY VG + N +++ Y+P TD W+ +A
Sbjct: 503 QWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMA 555
Score = 51.6 bits (122), Expect = 2e-06
Identities = 31/103 (30%), Positives = 51/103 (49%), Gaps = 12/103 (11%)
Query: 437 PFLPKYLSSPRCA-ALHGELYLIG------DNTKKVYVYDPGANLWQKVQSQHSLHENGA 489
P LP + + PRC ++ G +Y +G D+ V V+DP AN W++ + +
Sbjct: 271 PHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVG 330
Query: 490 LVPLGDALYVTGGRWQGMEGDYHVE-MEAYDTVRDTWTRHGAL 531
+ + LY GG +G + +EAY+ DTWTR G++
Sbjct: 331 VAVVNGLLYAIGG----YDGQLRLSTVEAYNPETDTWTRVGSM 369
Score = 38.9 bits (89), Expect = 0.013
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 6/88 (6%)
Query: 304 AALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYV 363
A+L + ++V GG G+ + A + W + PM R+ + A G +Y
Sbjct: 473 ASLGSKMFVCGGYDGSGF----LSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYA 528
Query: 364 IGGTT--LDVVEVESYDPYTDSWTPVSP 389
+GG ++ VE YDP TD WT ++P
Sbjct: 529 VGGYDGQSNLSSVEMYDPETDCWTFMAP 556
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 192 bits (489), Expect = 5e-49
Identities = 138/507 (27%), Positives = 230/507 (45%), Gaps = 54/507 (10%)
Query: 49 AESFSARVELRDVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYL 108
+ES + RV +++V+ + L+D+VYT + +T+ NV+ L A L V+K C +L
Sbjct: 2 SESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 61
Query: 109 QQQLDAANCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGD 168
+ QL NCLGI F + + KA + ++F V +EFL L E++ + ++ D
Sbjct: 62 ESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSD 121
Query: 169 LLQVQPEQSRLEALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESE 228
L + E+ EA++ WV HD R + L+ V L +PR + Q + E L++ S
Sbjct: 122 KLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSS 181
Query: 229 ACRAALSQGHDGAPLALQQK---------------LEEVLVVVGGQALEEEEAGEEPTPG 273
AC+ L + L +Q+ L +++VVVGGQA
Sbjct: 182 ACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA----------PKA 231
Query: 274 LGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGT----KTDTWSTTQA 329
+ + Y+ K +RW + + P + + + ++ GG G+ D++
Sbjct: 232 IRSVECYDFKEERWHQVAELPS-RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYD---- 286
Query: 330 WCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGG--TTLDVVEVESYDPYTDSWTPV 387
P+K+ W VA M R+ +A LNG +Y +GG + + VE+Y+ ++ W V
Sbjct: 287 ---PVKD-QWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHV 342
Query: 388 SPALKYVSNFSAAGCRGRLYLVG--SSACKYNALALQCYNPVTDAWSVIASPFLPKYLSS 445
+P S+ G LY VG A + ++CYN T+ W+ IA + S
Sbjct: 343 APMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE--MSTRRSG 400
Query: 446 PRCAALHGELYLIGDN-----TKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVT 500
L+ LY +G + K V VYDP N W++V + N + + LYV
Sbjct: 401 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVV 460
Query: 501 GGRWQGMEGDYHV-EMEAYDTVRDTWT 526
GG +G ++ +E Y+ D WT
Sbjct: 461 GGD----DGSCNLASVEYYNPTTDKWT 483
Score = 76.6 bits (187), Expect = 5e-14
Identities = 47/172 (27%), Positives = 74/172 (43%), Gaps = 5/172 (2%)
Query: 267 GEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWST 326
G + + GL + YN K+ W + + + + + +Y GG G ST
Sbjct: 319 GFDGSTGLSSVEAYNIKSNEWFHVAPM-NTRRSSVGVGVVGGLLYAVGGYDGASRQCLST 377
Query: 327 TQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTTLDVVE--VESYDPYTDSW 384
+ C+ W +A M R+ LN +Y +GG +V VE YDP T++W
Sbjct: 378 VE--CYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAW 435
Query: 385 TPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIAS 436
V+ N G LY+VG N +++ YNP TD W+V++S
Sbjct: 436 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 487
Score = 54.7 bits (130), Expect = 2e-07
Identities = 34/114 (29%), Positives = 51/114 (44%), Gaps = 7/114 (6%)
Query: 280 YNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASW 339
YN+ W + + + G + LNN +Y GG G + +W
Sbjct: 381 YNATTNEWTYIAEMST-RRSGAGVGVLNNLLYAVGGHDGPLV----RKSVEVYDPTTNAW 435
Query: 340 KPVAPMLKPRTNHASAALNGEIYVIGGT--TLDVVEVESYDPYTDSWTPVSPAL 391
+ VA M R N A+NG +YV+GG + ++ VE Y+P TD WT VS +
Sbjct: 436 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCM 489
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 192 bits (487), Expect = 9e-49
Identities = 143/517 (27%), Positives = 228/517 (44%), Gaps = 33/517 (6%)
Query: 30 RGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAVVGQLVDFVYTGRLTITQGNVEALT 89
R +L+ S YF AMF D E+ +++ VEP + L+ + YTGRL + + N+E L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 90 RTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAR 149
TA L V + C ++L +QL +NCLGI F + QG + A + E+F V R
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 150 EDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMRWVRHDPQARAAHLPELLSLVHLDAV 209
EF+ LP + LA D + + E++ L AL+ WVRHD + R L +LL+ + L +
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 210 PRPCVQQLLASEPLIQESEACRAALSQG------HDGAPLALQQKLEEVLVVVGGQALEE 263
P + + L ++ C+ + + + P+ + + VG
Sbjct: 354 -APQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLF--- 409
Query: 264 EEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDT 323
G + T G + Y+ + W + + + + F +A L++ +YV GG G KT
Sbjct: 410 AVGGMDSTKGATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVLDDKLYVVGGRDGLKT-- 466
Query: 324 WSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTT--LDVVEVESYDPYT 381
C+ K +W + PM R A L G +Y +GG + VE +DP
Sbjct: 467 --LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 524
Query: 382 DSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPK 441
W V+ S A G+LY VG +++C++P T+ W++ A + K
Sbjct: 525 RQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQ--MSK 582
Query: 442 YLSSPRCAALHGELYLIGDN-----------TKKVYVYDPGANLWQKVQSQHSLHENGAL 490
+G LY IG + + V YDP ++W V S + +
Sbjct: 583 RRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGV 642
Query: 491 VPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTR 527
LGD LY GG + G Y +EAYD + WT+
Sbjct: 643 CLLGDKLYAVGG-YDGQA--YLNTVEAYDPQTNEWTQ 676
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/247 (24%), Positives = 88/247 (35%), Gaps = 79/247 (31%)
Query: 249 LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNN 308
L++ L VVGG+ + L YN K K W +P H+ G +A L
Sbjct: 451 LDDKLYVVGGR---------DGLKTLNTVECYNPKTKTWSVMPPMST-HRHGLGVAVLEG 500
Query: 309 NIYVTGGSRGTKTDTWS---TTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVI- 364
+Y GG G WS T + W ++ W VA M PR+ A L+G++Y +
Sbjct: 501 PMYAVGGHDG-----WSYLNTVERWDPQARQ--WNFVATMSTPRSTVGVAVLSGKLYAVG 553
Query: 365 ---GGTTLDVVE------------------------------------------------ 373
G + L VE
Sbjct: 554 GRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 613
Query: 374 ---VESYDPYTDSWTPVSPALKYVSNFSAAGCR--GRLYLVGSSACKYNALALQCYNPVT 428
VE YDP TD WT V A +S + C +LY VG + ++ Y+P T
Sbjct: 614 SDCVERYDPKTDMWTAV--ASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQT 671
Query: 429 DAWSVIA 435
+ W+ +A
Sbjct: 672 NEWTQVA 678
Score = 37.0 bits (84), Expect = 0.048
Identities = 26/94 (27%), Positives = 37/94 (39%), Gaps = 4/94 (4%)
Query: 300 GFSLAALNNNIYVTGGSRGTKTDTWSTTQAWC--FPLKEASWKPVAPMLKPRTNHASAAL 357
G + N +Y GG ++ S + K W VA M R L
Sbjct: 586 GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL 645
Query: 358 NGEIYVIGGTTLDVV--EVESYDPYTDSWTPVSP 389
++Y +GG VE+YDP T+ WT V+P
Sbjct: 646 GDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP 679
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 184 bits (468), Expect = 1e-46
Identities = 151/554 (27%), Positives = 239/554 (43%), Gaps = 94/554 (16%)
Query: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
+L+ + LR L DVTL V ++ P HR +LA S YF AMF + +E V+++
Sbjct: 19 ILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQG 78
Query: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
+ + + L+DFVYT + +T NV+ L A L V++ C +L+ QLD +NCLGI
Sbjct: 79 LTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGI 138
Query: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPR---ERLVTCLAGDLLQVQPEQS 177
+F E + + A F +++F V + +EF+ L + E+L+ C D +QV E+
Sbjct: 139 RDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKC---DEIQVDSEEP 195
Query: 178 RLEALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQG 237
EA++ WV+H + R LP LL V + + + ++ +EP I+ S CR + +
Sbjct: 196 VFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEA 255
Query: 238 H------------DGAPLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAK 285
G + EVL+VVGG G + +P + Y+ K +
Sbjct: 256 KKFHLRPELRSQMQGPRTRARLGANEVLLVVGG-------FGSQQSP-IDVVEKYDPKTQ 307
Query: 286 RWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKE-ASWKPVAP 344
W LP ++ S+ +L++ IYV GG G S+ + + E W VAP
Sbjct: 308 EWSFLPSITRKRRYVASV-SLHDRIYVIGGYDG--RSRLSSVECLDYTADEDGVWYSVAP 364
Query: 345 MLKPRTNHASAALNGEIYVIGG-------TTLD--------------------------- 370
M R + L IYV GG T+++
Sbjct: 365 MNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVA 424
Query: 371 ---------------VVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACK 415
+ VE YDP+T WT V+P S A +Y+VG
Sbjct: 425 SGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGT 484
Query: 416 YNALALQCYNPVTDAWSVIASPFLPKYLSSPRC----AALHGELYLI-----GDNTKKVY 466
+ +++ YN TD+W+ + S +++PRC L G LY I +
Sbjct: 485 AHLSSVEAYNIRTDSWTTVTS------MTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIE 538
Query: 467 VYDPGANLWQKVQS 480
YDP + W+ V S
Sbjct: 539 CYDPIIDSWEVVTS 552
Score = 69.7 bits (169), Expect = 7e-12
Identities = 50/173 (28%), Positives = 71/173 (41%), Gaps = 13/173 (7%)
Query: 280 YNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASW 339
Y+ +W L D + G L + IY GG G + W
Sbjct: 399 YDPNIDQWSMLGDMQTARE-GAGLVVASGVIYCLGGYDGLNI----LNSVEKYDPHTGHW 453
Query: 340 KPVAPMLKPRTNHASAALNGEIYVIGGT--TLDVVEVESYDPYTDSWTPVSPALKYVSNF 397
V PM R+ A LN IYV+GG T + VE+Y+ TDSWT V+
Sbjct: 454 TNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYV 513
Query: 398 SAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAA 450
A RGRLY + +++CY+P+ D+W V+ S + + RC A
Sbjct: 514 GATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTS------MGTQRCDA 560
Score = 40.8 bits (94), Expect = 0.003
Identities = 40/142 (28%), Positives = 56/142 (39%), Gaps = 22/142 (15%)
Query: 401 GCRGRLYLVGSSACKYNAL-ALQCYNPVTDAWSVIASPFLPKYLSSPRCAA---LHGELY 456
G L +VG + + + ++ Y+P T WS FLP R A LH +Y
Sbjct: 278 GANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWS-----FLPSITRKRRYVASVSLHDRIY 332
Query: 457 LIG-----DNTKKVYVYDPGAN---LWQKVQSQHSLHENGALVPLGDALYVTGGRWQGME 508
+IG V D A+ +W V + LGD +YV+GG +
Sbjct: 333 VIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGG----FD 388
Query: 509 GDY-HVEMEAYDTVRDTWTRHG 529
G H ME YD D W+ G
Sbjct: 389 GSRRHTSMERYDPNIDQWSMLG 410
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 184 bits (466), Expect = 2e-46
Identities = 139/541 (25%), Positives = 240/541 (44%), Gaps = 41/541 (7%)
Query: 8 LRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAVVG 67
LR + KL DV + V G E H+ +L S YF A+F + + + + P ++
Sbjct: 32 LRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMK 91
Query: 68 QLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGEQQ 127
++++ YT + IT NVE L A + + + + C +L+ +L NC+GIC+F +
Sbjct: 92 LIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYY 151
Query: 128 GLLGVAAKAWAFLRENFEAVAR-EDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMRWV 186
+ KA+ F+ NFE + + EFL+L L + D L V+ E + EA+++W+
Sbjct: 152 YCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWI 211
Query: 187 RHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAAL------------ 234
HDPQ R H+ LL V L + + +++SE C+ +
Sbjct: 212 SHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNM 271
Query: 235 ---SQGHDGAPLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALP 291
S PL + +L +GG +G PT + Y+++A RW+ +
Sbjct: 272 NGPSNSDFTNPLTRPRLPYAILFAIGGW------SGGSPTNAI---EAYDARADRWVNVT 322
Query: 292 DFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTN 351
+ + A L +Y+ GG D +++ + + P+K+ +W VAPM R
Sbjct: 323 CEEESPRAYHGAAYLKGYVYIIGGF--DSVDYFNSVKRF-DPVKK-TWHQVAPMHSRRCY 378
Query: 352 HASAALNGEIYVIGGTT--LDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLV 409
+ L IY +GG + + E Y+P T+ WT ++P + S+ SA G++Y+
Sbjct: 379 VSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438
Query: 410 GSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIG-----DNTKK 464
G + YN ++ W+VIA + S A +Y +G + +
Sbjct: 439 GGFNGNECLFTAEVYNTESNQWTVIAP--MRSRRSGIGVIAYGEHVYAVGGFDGANRLRS 496
Query: 465 VYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDT 524
Y P AN W+ + + + N + + D L+V GG + G ++V E YD D
Sbjct: 497 AEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG-FNGFTTTFNV--ECYDEKTDE 553
Query: 525 W 525
W
Sbjct: 554 W 554
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 183 bits (465), Expect = 3e-46
Identities = 141/540 (26%), Positives = 249/540 (46%), Gaps = 37/540 (6%)
Query: 5 LQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPA 64
+ +R Q L DV L+V R++P HR +LA +S +F+ MF + ES S VEL+D EP
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
Query: 65 VVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFG 124
++ QLV+F YT R+++ NV++L A + V+K+C +L++Q+DA+NCLGI
Sbjct: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
Query: 125 EQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMR 184
E + A A F+ ++F V + DEFLQL +R+ L D L V+ E +A +R
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
Query: 185 WVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLA 244
W+++D R + ++L+ V + + + + + +EPLIQ++ C + G L+
Sbjct: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
Query: 245 LQQKLEEVLVVVGGQALEEEE-------AGEEPTPGLGNFAFYNSKAKRWMALPDFPDYH 297
+ + E +V G + ++ G +P + ++N K W + P
Sbjct: 274 PEDREE---LVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDI-RCPFEK 325
Query: 298 KWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAAL 357
+ + +N +Y+ GGS+ + + C+ + + SW PR + A+ A
Sbjct: 326 RRDAACVFWDNVVYILGGSQ-----LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAA 380
Query: 358 NGEIYVIGGTTLD---VVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSAC 414
G+IY GG+ + + E YD T+SW L + G +Y+ G S
Sbjct: 381 EGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLG 440
Query: 415 KYNA----LALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDNT-----KKV 465
+ + + Y+P T+ W+ + + + + + +++ +G V
Sbjct: 441 NNVSGRVLNSCEVYDPATETWTELCP--MIEARKNHGLVFVKDKIFAVGGQNGLGGLDNV 498
Query: 466 YVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTW 525
YD N W+ V +G +YV G +QG+ H+ Y+T D W
Sbjct: 499 EYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAG-FQGVGRLGHI--LEYNTETDKW 555
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 179 bits (453), Expect = 8e-45
Identities = 139/531 (26%), Positives = 245/531 (46%), Gaps = 37/531 (6%)
Query: 14 LADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAVVGQLVDFV 73
L DV L+V R++P HR +LA +S +F+ MF + ES S VEL+D EP ++ QLV+F
Sbjct: 21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
Query: 74 YTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGEQQGLLGVA 133
YT R+++ NV++L A + V+K+C +L++Q+DA+NCLGI E +
Sbjct: 81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
Query: 134 AKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMRWVRHDPQAR 193
A A F+ ++F V + DEFLQL +R+ L D L V+ E +A +RW+++D R
Sbjct: 141 ATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 200
Query: 194 AAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLALQQKLEEVL 253
+ ++L+ V + + + + + +EPLIQ++ C + G L+ + + E
Sbjct: 201 QPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREE--- 257
Query: 254 VVVGGQALEEEE-------AGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAAL 306
+V G + ++ G +P + ++N K W + P + +
Sbjct: 258 LVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDI-RCPFEKRRDAACVFW 312
Query: 307 NNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGG 366
+N +Y+ GGS+ + + C+ + + SW PR + A+ A G+IY GG
Sbjct: 313 DNVVYILGGSQ-----LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGG 367
Query: 367 TTLD---VVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSACKYNA----L 419
+ + + E YD T+SW L + G +Y+ G S +
Sbjct: 368 SEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLN 427
Query: 420 ALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDNT-----KKVYVYDPGANL 474
+ + Y+P T+ W+ + + + + + +++ +G V YD N
Sbjct: 428 SCEVYDPATETWTELCP--MIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNE 485
Query: 475 WQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTW 525
W+ V +G +YV G +QG+ H+ Y+T D W
Sbjct: 486 WKMVSPMPWKGVTVKCAAVGSIVYVLAG-FQGVGRLGHI--LEYNTETDKW 533
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,381,884
Number of Sequences: 37866
Number of extensions: 1086555
Number of successful extensions: 3359
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 2269
Number of HSP's gapped (non-prelim): 345
length of query: 560
length of database: 18,247,518
effective HSP length: 107
effective length of query: 453
effective length of database: 14,195,856
effective search space: 6430722768
effective search space used: 6430722768
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.