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Search of human proteins with 40255071
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40255071 kelch-like 23 [Homo sapiens]
(558 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40255071 kelch-like 23 [Homo sapiens] 1170 0.0
gi|40018614 DRE1 protein [Homo sapiens] 273 3e-73
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 266 4e-71
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 258 1e-68
gi|109150407 kelch-like 6 [Homo sapiens] 254 1e-67
gi|55925608 kelch-like 21 [Homo sapiens] 249 5e-66
gi|40807500 kelch-like 20 [Homo sapiens] 248 8e-66
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 246 3e-65
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 246 3e-65
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 245 7e-65
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 245 7e-65
gi|166235129 kelch-like 3 [Homo sapiens] 241 1e-63
gi|11056006 kelch-like 12 [Homo sapiens] 236 3e-62
gi|148664209 kelch-like 10 [Homo sapiens] 233 3e-61
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 232 6e-61
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 227 2e-59
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 227 2e-59
gi|55925604 kelch-like 18 [Homo sapiens] 227 2e-59
gi|38194229 kelch-like 17 [Homo sapiens] 226 3e-59
gi|128485503 kelch-like 30 [Homo sapiens] 226 3e-59
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 224 2e-58
gi|14780904 kelch-like 1 protein [Homo sapiens] 222 6e-58
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 221 2e-57
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 220 2e-57
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 220 2e-57
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 220 2e-57
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 218 2e-56
gi|34101268 kelch-like 8 [Homo sapiens] 214 2e-55
gi|194097389 kelch-like 38 [Homo sapiens] 207 3e-53
gi|24308181 kelch-like 9 [Homo sapiens] 201 1e-51
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 1170 bits (3026), Expect = 0.0
Identities = 558/558 (100%), Positives = 558/558 (100%)
Query: 1 MALKGQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSN 60
MALKGQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSN
Sbjct: 1 MALKGQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSN 60
Query: 61 YFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFL 120
YFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFL
Sbjct: 61 YFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFL 120
Query: 121 SVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISL 180
SVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISL
Sbjct: 121 SVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISL 180
Query: 181 EKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALG 240
EKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALG
Sbjct: 181 EKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALG 240
Query: 241 LQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMYIIGGYYWHPLSEVHIWDPLTNVWI 300
LQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMYIIGGYYWHPLSEVHIWDPLTNVWI
Sbjct: 241 LQRSCLLTENKIRSLIYNALNPMHKEISQRSTATMYIIGGYYWHPLSEVHIWDPLTNVWI 300
Query: 301 QGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARY 360
QGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARY
Sbjct: 301 QGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARY 360
Query: 361 YHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYV 420
YHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYV
Sbjct: 361 YHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYV 420
Query: 421 IGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITEC 480
IGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITEC
Sbjct: 421 IGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITEC 480
Query: 481 YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIV 540
YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIV
Sbjct: 481 YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIV 540
Query: 541 GNLPSAMRSHGCVCVYNV 558
GNLPSAMRSHGCVCVYNV
Sbjct: 541 GNLPSAMRSHGCVCVYNV 558
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 273 bits (698), Expect = 3e-73
Identities = 177/559 (31%), Positives = 280/559 (50%), Gaps = 31/559 (5%)
Query: 16 STHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFK 75
S+H + L F F LFTD+ + C G F CHRAVL+ACS+YF+AMF D +E +
Sbjct: 46 SSHAENILQIFNEFRDSRLFTDVII-CVEGKEFPCHRAVLSACSSYFRAMFCNDHRESRE 104
Query: 76 NKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLD 135
++++GI + +E + Y YT +++IT NVQ L E + L Q ++ AC +FL LD
Sbjct: 105 MLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLD 164
Query: 136 IDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVW 195
NC+G+ FA+ H L + + F++V Q EEFLE+ ++ + + L +
Sbjct: 165 PCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIG 224
Query: 196 KEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYLKTALGLQR------SC--L 246
KEE + E V++W V+ R L+ LL+++ + + P Y + + + C L
Sbjct: 225 KEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQL 284
Query: 247 LTENKIRSLIYN-ALNPMHKEISQRSTA---TMYIIGG---YYWHPLSEVHIWDPLTNVW 299
L E + ++ N ++P + +RST + ++GG L +DP+T W
Sbjct: 285 LHEARRYHILGNEMMSPRTR--PRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEW 342
Query: 300 IQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNAR 359
A++P++T+ Y V L +I V+GG I + D VWIYNS+ + W + R
Sbjct: 343 KSLAKLPEFTKSEYAVCALRNDILVSGG----RINSRD-VWIYNSQLNIWIRVASLNKGR 397
Query: 360 YYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGN--ATACVLHDV 417
+ H L G VY +GGY E YD +W +A + + V + T+CV
Sbjct: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCV--GK 455
Query: 418 IYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTI 477
++VIGG G + DKVQSY+ + N W L + P + + +V N +Y+ GG T
Sbjct: 456 LFVIGG--GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKA 513
Query: 478 TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537
CYDP ++ W + R+ CG + NG IY+ GG G +I YDP +
Sbjct: 514 IYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG-RRENGEATDTILCYDPATSII 572
Query: 538 EIVGNLPSAMRSHGCVCVY 556
V +P + HGCV ++
Sbjct: 573 TGVAAMPRPVSYHGCVTIH 591
Score = 77.4 bits (189), Expect = 3e-14
Identities = 59/211 (27%), Positives = 88/211 (41%), Gaps = 18/211 (8%)
Query: 354 PMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATA-C 412
P + Y V +GGC +GG+ E YDP+ +W +A + + + A C
Sbjct: 305 PRRSTGYSEVIVVVGGCE-RVGGFN----LPYTECYDPVTGEWKSLAKLPEFTKSEYAVC 359
Query: 413 VLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVG 472
L + I V GG R V YNS +N W + S + K+Y+VG
Sbjct: 360 ALRNDILVSGGRINSRD------VWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVG 413
Query: 473 G-----QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSI 527
G + + ECYD N W E+AP+ E G ++V GG T +
Sbjct: 414 GYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGG-GPDDNTCSDKV 472
Query: 528 EKYDPDLNKWEIVGNLPSAMRSHGCVCVYNV 558
+ YDP+ N W + +P A R V + N+
Sbjct: 473 QSYDPETNSWLLRAAIPIAKRCITAVSLNNL 503
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 266 bits (680), Expect = 4e-71
Identities = 165/568 (29%), Positives = 293/568 (51%), Gaps = 42/568 (7%)
Query: 10 IYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTAD 69
IYLF S++ L LFTD+ L + F CHRAVLAACS YF+AMF+
Sbjct: 20 IYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRT-FPCHRAVLAACSRYFEAMFSGG 78
Query: 70 MKEKFKNKIKL-SGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACER 128
+KE +++ + IH ++LE L++YAY+S++ I + N +SLLEA D+L+F ++ AC
Sbjct: 79 LKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAE 138
Query: 129 FLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILS 188
FL ++L NC+GM ++ H C +L + S R+ S F+ + + E+FL++ + + +LS
Sbjct: 139 FLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLS 198
Query: 189 RKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDP-VYLKTALGLQRSCLL 247
+ L E + E I W ++D++ R L LL + + + P +YL + ++ +
Sbjct: 199 SEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAME-ELIT 257
Query: 248 TENKIRSLIYNALNPMHKEISQRSTAT------------MYIIGGYYWHPLSEVHIWDPL 295
+ K + ++ A+ K + T ++++GG + ++++ D
Sbjct: 258 KQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTF-MCDKLYLVDQK 316
Query: 296 TNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPM 355
I A+IP R+ + +G +Y+TGG ++N + D VW+Y++ +EW++ PM
Sbjct: 317 AKEIIPKADIPS-PRKEFSACAIGCKVYITGGRGSENGVSKD-VWVYDTLHEEWSKAAPM 374
Query: 356 LNARYYHCAVTLGGCVYALGGYRKGA---PA------EEAEFYDPLKEKWIPIANMIKGV 406
L AR+ H + L C+Y +GG+ PA ++ E YDP KW +A + +GV
Sbjct: 375 LVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGV 434
Query: 407 GNATACVLHDVIYVIGGHCGYRGSCTYD---KVQSYNSDINEWSLITSSPHPEYGLCSVP 463
NA ++ GG S ++D KVQ Y+ N W++ + P P +
Sbjct: 435 SNAAVVSAKLKLFAFGG-----TSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAV 489
Query: 464 FENKLYLVGGQTTITEC----YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYS 519
N+++++GG T + C ++ E +W ++ + +RM C AV +YV GGY
Sbjct: 490 LGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGI 549
Query: 520 KGTYLQSIEKYDPDLNKWEIVGNLPSAM 547
+ ++++ YDP L+ W + +P ++
Sbjct: 550 Q--RCKTLDCYDPTLDVWNSITTVPYSL 575
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 258 bits (659), Expect = 1e-68
Identities = 166/564 (29%), Positives = 284/564 (50%), Gaps = 34/564 (6%)
Query: 10 IYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTAD 69
+ LF ++HP L T +FTD+TL F CHRAVLAA S YF+AMF+
Sbjct: 20 VTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRA-FPCHRAVLAASSRYFEAMFSHG 78
Query: 70 MKEKFKNKIKLS-GIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACER 128
++E + + +H ++LE L+++AY+S+I I + N +SLLEA D+LQF V+ A
Sbjct: 79 LRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAE 138
Query: 129 FLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILS 188
FL ++L NC+GM ++ H C L + S R+ F+ V Q E+F +S + L ++S
Sbjct: 139 FLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLIS 198
Query: 189 RKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRSCLLT 248
L E + E +++W HD+E R L LL + + + P + L+
Sbjct: 199 SDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMA 258
Query: 249 ENKIRSLIYNALNPMHKEIS------------QRSTATMYIIGGYYWHPLSEVHIWDPLT 296
+ + + ++ AL + + +++ T+ I+GG + +++ D
Sbjct: 259 DERTKLIMDEALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTF-MCDKIYQVDHKA 317
Query: 297 NVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPML 356
I A++P R+ + + +G +YVTGG ++N + D VW+Y++ +EW++ PML
Sbjct: 318 KEIIPKADLPS-PRKEFSASAIGCKVYVTGGRGSENGVSKD-VWVYDTVHEEWSKAAPML 375
Query: 357 NARYYHCAVTLGGCVYALGGYRKGA---PA------EEAEFYDPLKEKWIPIANMIKGVG 407
AR+ H + L C+Y +GG+ A PA ++ E YDP KW+ +A + GV
Sbjct: 376 IARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVS 435
Query: 408 NATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENK 467
NA ++V GG +R + KVQ Y+ N W++ P P + ++
Sbjct: 436 NAAVVSAKLKLFVFGGTSIHRDMVS--KVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQ 493
Query: 468 LYLVGGQTTITEC----YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTY 523
++++GG T T +D E N+W I M +RM C A+ +YV GGY ++
Sbjct: 494 IFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQ--R 551
Query: 524 LQSIEKYDPDLNKWEIVGNLPSAM 547
++++ YDP + W + +P ++
Sbjct: 552 CKTLDCYDPTSDTWNCITTVPYSL 575
Score = 59.3 bits (142), Expect = 9e-09
Identities = 45/166 (27%), Positives = 67/166 (40%), Gaps = 17/166 (10%)
Query: 397 IPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPE 456
IP A++ +A + +YV GG G V Y++ EWS
Sbjct: 321 IPKADLPSPRKEFSASAIGCKVYVTGGRGSENG--VSKDVWVYDTVHEEWSKAAPMLIAR 378
Query: 457 YGLCSVPFENKLYLVGGQTTIT--------------ECYDPEQNEWREIAPMMERRMECG 502
+G S EN LY+VGG T++ E YDP N+W +AP+ +
Sbjct: 379 FGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAA 438
Query: 503 AVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMR 548
V ++V GG S + + ++ YDP N+W I P R
Sbjct: 439 VVSAKLKLFVFGGTSIHRDM-VSKVQCYDPSENRWTIKAECPQPWR 483
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 254 bits (650), Expect = 1e-67
Identities = 175/571 (30%), Positives = 274/571 (47%), Gaps = 43/571 (7%)
Query: 13 FKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKE 72
F D+ + + T ++ TD+ L C F CHR VLAA SNYF+AMF D+KE
Sbjct: 49 FDDAGLSLILQNGLETLRMENALTDVIL-CVDIQEFSCHRVVLAAASNYFRAMFCNDLKE 107
Query: 73 KFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVR 132
K++ +I + G+ + + L++Y YTS+ ITK+NVQ +LEAA+L QFL + AC FL
Sbjct: 108 KYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTE 167
Query: 133 HLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNL 192
L+ +NC+G+ A+ H L+K+ + + F ++ EEFL++ ++ IL +L
Sbjct: 168 ALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDL 227
Query: 193 SVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYLKTAL---GLQRSC--- 245
V +E + E V+ W H R+ L +L + + +DP Y + L R C
Sbjct: 228 YVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEV 287
Query: 246 --LLTENKIRSLIYNALNPMHKEISQRSTATMY--------IIGGYYWHP--LSEVHIWD 293
LL E ++ L N + IS+R+ M+ IIGG ++EV D
Sbjct: 288 FPLLQEARMYHLSGNEI------ISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLD 341
Query: 294 PLTNVWIQGAEIP--DYTRES-------YGVTCLGPNIYVTGGYRTDNIEALDTVWIYNS 344
PL ++ A++P ++ ES + L +Y++GG T + VW YNS
Sbjct: 342 PLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQH-----DVWKYNS 396
Query: 345 ESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIK 404
++W + + R+ H V LGG VY +GG+ E YDP W A ++
Sbjct: 397 SINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLV 456
Query: 405 GVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPF 464
V + A +YVIGG G G DK Q Y+ N+WSL + P + +V F
Sbjct: 457 HVSSFAATSHKKKLYVIGG--GPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSF 514
Query: 465 ENKLYLVGGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYL 524
+++Y+VGG Y P ++ W + + R CG N +Y+TGG K +
Sbjct: 515 RDRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRD-EKNEVI 573
Query: 525 QSIEKYDPDLNKWEIVGNLPSAMRSHGCVCV 555
++ +DP+ K LP + HG V +
Sbjct: 574 ATVLCWDPEAQKLTEECVLPRGVSHHGSVTI 604
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 249 bits (636), Expect = 5e-66
Identities = 166/565 (29%), Positives = 259/565 (45%), Gaps = 38/565 (6%)
Query: 13 FKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKE 72
F D H + L + F D+TL+ G F HRAVLAA S YF+AMF ++E
Sbjct: 12 FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRE 71
Query: 73 KFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVR 132
+++L G+ D+L+ L++++YT ++ ++ N + LL AADLLQF +VK+AC FL +
Sbjct: 72 SRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQ 131
Query: 133 HLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNL 192
LD+ NC+ M FAE C L ++R + E+ E+ + L + L L L
Sbjct: 132 QLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGL 190
Query: 193 SVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYI------------NIDIDPVYLKTALG 240
V KEEA + ++W D R LL + +++ +P+ +
Sbjct: 191 CVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPC 250
Query: 241 LQRSCLLTENKIRSLIYNALNPMHKEISQRSTAT---MYIIGG--YYWHPLSEVHIWDPL 295
L+ + + + P + + ST + ++GG L V ++P
Sbjct: 251 LRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQ 310
Query: 296 TNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPM 355
T W AE PD+ Y + LG +IYVTGG +D D VW YNS +EW E PM
Sbjct: 311 TGQWRYLAEFPDHLGGGYSIVALGNDIYVTGG--SDGSRLYDCVWRYNSSVNEWAEVAPM 368
Query: 356 LNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLH 415
L AR YH + L G +Y + A+ E YD + W + M + N +
Sbjct: 369 LKAREYHSSSVLDGLLYVVA-------ADSTERYDHTTDSWEALQPMTYPMDNCSTTACR 421
Query: 416 DVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLC--SVPFENKLYLVGG 473
+Y IG G +Q Y+ D + WSL+ P + + +Y V
Sbjct: 422 GRLYAIGSLAGKETMV----MQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRD 477
Query: 474 QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQS--IEKYD 531
+ + Y+P +NEW +I M + + ++ G +YV+GGY T+ S +E YD
Sbjct: 478 DSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYD---NTFELSDVVEAYD 534
Query: 532 PDLNKWEIVGNLPSAMRSHGCVCVY 556
P+ W +VG LP HG V ++
Sbjct: 535 PETRAWSVVGRLPEPTFWHGSVSIF 559
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 248 bits (634), Expect = 8e-66
Identities = 162/548 (29%), Positives = 267/548 (48%), Gaps = 32/548 (5%)
Query: 18 HPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNK 77
HP L+ D+ L + I+ HR +L+ACS YF+AMFT ++ E + +
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIY-AHRVILSACSPYFRAMFTGELAESRQTE 108
Query: 78 IKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDID 137
+ + I +E L+++AYTSQI + + NVQ+LL AA LLQ +++AC FL R LD
Sbjct: 109 VVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPS 168
Query: 138 NCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKE 197
NC+G+ +FA+ H C EL + + + F+EV + EEF+ + + + I+S L+V E
Sbjct: 169 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSE 228
Query: 198 EAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYLKTALGLQRSCLLTENKIRSLI 256
E + V+ W + ++ R L +L ++ + + P +L +G + ++ + R L+
Sbjct: 229 EQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVG-SDPLIKSDEECRDLV 287
Query: 257 YNALN----PMHKEISQ----------RSTATMYIIGGY-YWHPLSEVHIWDPLTNVWIQ 301
A N P + + Q R ++ +GG+ +S V +DP TN W
Sbjct: 288 DEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRM 347
Query: 302 GAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGL-PMLNARY 360
A + R GV+ L +Y GG+ D L++V Y+ ++++W+ + P R
Sbjct: 348 VASM-SKRRCGVGVSVLDDLLYAVGGH--DGSSYLNSVERYDPKTNQWSSDVAPTSTCRT 404
Query: 361 YHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYV 420
LGG +YA+GG + E YDP + KW +A+M VL +Y
Sbjct: 405 SVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYA 464
Query: 421 IGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITEC 480
+GG G+ + V+ YN N W I L +++ +Y VGG+ TE
Sbjct: 465 VGGS---DGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTEL 521
Query: 481 -----YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLN 535
Y+P N+W + M RR G ++NG + GG+ + TYL++IE +DPD N
Sbjct: 522 SSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGT--TYLKTIEVFDPDAN 579
Query: 536 KWEIVGNL 543
W + G +
Sbjct: 580 TWRLYGGM 587
Score = 102 bits (254), Expect = 9e-22
Identities = 62/197 (31%), Positives = 97/197 (49%), Gaps = 17/197 (8%)
Query: 365 VTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGH 424
+ G ++A+GG+ G E YDP +W +A+M K VL D++Y +GGH
Sbjct: 314 IRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGH 373
Query: 425 CGYRGSCTYDKVQSYNSDINEWS---LITSSPHPEYGLCSVPFENKLYLVGGQT-----T 476
GS + V+ Y+ N+WS TS+ G+ + LY VGGQ
Sbjct: 374 ---DGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLG--GFLYAVGGQDGVSCLN 428
Query: 477 ITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTY-LQSIEKYDPDLN 535
I E YDP++N+W +A M RR+ ++ G +Y GG S GT L ++E+Y+P N
Sbjct: 429 IVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGG---SDGTSPLNTVERYNPQEN 485
Query: 536 KWEIVGNLPSAMRSHGC 552
+W + + + + GC
Sbjct: 486 RWHTIAPMGTRRKHLGC 502
Score = 100 bits (248), Expect = 5e-21
Identities = 69/238 (28%), Positives = 102/238 (42%), Gaps = 11/238 (4%)
Query: 275 MYIIGGYYWHP-LSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNI 333
+Y +GG+ L+ V +DP TN W R S GV LG +Y GG D +
Sbjct: 367 LYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQ--DGV 424
Query: 334 EALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLK 393
L+ V Y+ + ++WT M R LGG +YA+GG +P E Y+P +
Sbjct: 425 SCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQE 484
Query: 394 EKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSP 453
+W IA M + V D+IY +GG + + YN N+WS + +
Sbjct: 485 NRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR---DDTTELSSAERYNPRTNQWSPVVAMT 541
Query: 454 HPEYGLCSVPFENKLYLVGGQTTIT-----ECYDPEQNEWREIAPMMERRMECGAVIM 506
G+ +L VGG T E +DP+ N WR M RR+ G ++
Sbjct: 542 SRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 599
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 246 bits (629), Expect = 3e-65
Identities = 170/544 (31%), Positives = 257/544 (47%), Gaps = 31/544 (5%)
Query: 34 LFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVN 93
L D+T+ I HR VLAACS YF AMFT +M E ++++ + L L++
Sbjct: 58 LLCDVTIVAEDMEI-SAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLID 116
Query: 94 YAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPE 153
Y YT++I++T+ NVQ LL AA LLQ VKK C FL L NC+G+ +FA+ H C +
Sbjct: 117 YVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTD 176
Query: 154 LEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVE 213
L ++ F +V EEFL + +E+ ++S L++ EE + E VI W HD +
Sbjct: 177 LLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 236
Query: 214 NRIECLYNLLSYINIDIDP-VYL-----KTALGLQRSCLLTENKIRSLIYNALNPMHKEI 267
R E + L+ ++ + + P YL + AL ++ S + I ++ Y+ L P + I
Sbjct: 237 VRQEFMARLMEHVRLPLLPREYLVQRVEEEAL-VKNSSACKDYLIEAMKYHLL-PTEQRI 294
Query: 268 SQRSTAT-----------MYIIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVT 316
+S T M ++GG + V +D W Q AE+P R G+
Sbjct: 295 LMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPS-RRCRAGMV 353
Query: 317 CLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGG 376
+ ++ GG+ + + TV Y+ D+WT M + R A L G +YA+GG
Sbjct: 354 YMAGLVFAVGGF--NGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG 411
Query: 377 YRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKV 436
+ E Y+ +W +A M + V+ ++Y +GG+ G C V
Sbjct: 412 FDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQC-LSTV 470
Query: 437 QSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQ-----TTITECYDPEQNEWREI 491
+ YN+ NEW+ I G N LY VGG E YDP N WR++
Sbjct: 471 ECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQV 530
Query: 492 APMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHG 551
A M R G +NG +YV GG S L S+E Y+P +KW +V + S RS+
Sbjct: 531 ADMNMCRRNAGVCAVNGLLYVVGGDDGS--CNLASVEYYNPTTDKWTVVSSCMSTGRSYA 588
Query: 552 CVCV 555
V V
Sbjct: 589 GVTV 592
Score = 75.9 bits (185), Expect = 9e-14
Identities = 49/176 (27%), Positives = 79/176 (44%), Gaps = 9/176 (5%)
Query: 387 EFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEW 446
E YD +E+W +A + A + +++ +GG + GS V SY+ ++W
Sbjct: 328 ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG---FNGSLRVRTVDSYDPVKDQW 384
Query: 447 SLITSSPHPEYGLCSVPFENKLYLVGGQTTIT-----ECYDPEQNEWREIAPMMERRMEC 501
+ + + L + LY VGG T E Y+ + NEW +APM RR
Sbjct: 385 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 444
Query: 502 GAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCVYN 557
G ++ G +Y GGY + L ++E Y+ N+W + + S RS V V N
Sbjct: 445 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM-STRRSGAGVGVLN 499
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 246 bits (629), Expect = 3e-65
Identities = 170/544 (31%), Positives = 257/544 (47%), Gaps = 31/544 (5%)
Query: 34 LFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVN 93
L D+T+ I HR VLAACS YF AMFT +M E ++++ + L L++
Sbjct: 54 LLCDVTIVAEDMEI-SAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLID 112
Query: 94 YAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPE 153
Y YT++I++T+ NVQ LL AA LLQ VKK C FL L NC+G+ +FA+ H C +
Sbjct: 113 YVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTD 172
Query: 154 LEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVE 213
L ++ F +V EEFL + +E+ ++S L++ EE + E VI W HD +
Sbjct: 173 LLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKD 232
Query: 214 NRIECLYNLLSYINIDIDP-VYL-----KTALGLQRSCLLTENKIRSLIYNALNPMHKEI 267
R E + L+ ++ + + P YL + AL ++ S + I ++ Y+ L P + I
Sbjct: 233 VRQEFMARLMEHVRLPLLPREYLVQRVEEEAL-VKNSSACKDYLIEAMKYHLL-PTEQRI 290
Query: 268 SQRSTAT-----------MYIIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVT 316
+S T M ++GG + V +D W Q AE+P R G+
Sbjct: 291 LMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPS-RRCRAGMV 349
Query: 317 CLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGG 376
+ ++ GG+ + + TV Y+ D+WT M + R A L G +YA+GG
Sbjct: 350 YMAGLVFAVGGF--NGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG 407
Query: 377 YRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKV 436
+ E Y+ +W +A M + V+ ++Y +GG+ G C V
Sbjct: 408 FDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQC-LSTV 466
Query: 437 QSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQ-----TTITECYDPEQNEWREI 491
+ YN+ NEW+ I G N LY VGG E YDP N WR++
Sbjct: 467 ECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQV 526
Query: 492 APMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHG 551
A M R G +NG +YV GG S L S+E Y+P +KW +V + S RS+
Sbjct: 527 ADMNMCRRNAGVCAVNGLLYVVGGDDGS--CNLASVEYYNPTTDKWTVVSSCMSTGRSYA 584
Query: 552 CVCV 555
V V
Sbjct: 585 GVTV 588
Score = 75.9 bits (185), Expect = 9e-14
Identities = 49/176 (27%), Positives = 79/176 (44%), Gaps = 9/176 (5%)
Query: 387 EFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEW 446
E YD +E+W +A + A + +++ +GG + GS V SY+ ++W
Sbjct: 324 ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG---FNGSLRVRTVDSYDPVKDQW 380
Query: 447 SLITSSPHPEYGLCSVPFENKLYLVGGQTTIT-----ECYDPEQNEWREIAPMMERRMEC 501
+ + + L + LY VGG T E Y+ + NEW +APM RR
Sbjct: 381 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 440
Query: 502 GAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCVYN 557
G ++ G +Y GGY + L ++E Y+ N+W + + S RS V V N
Sbjct: 441 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM-STRRSGAGVGVLN 495
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 245 bits (626), Expect = 7e-65
Identities = 175/570 (30%), Positives = 258/570 (45%), Gaps = 30/570 (5%)
Query: 11 YLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADM 70
Y F D HP + L FTD+ + G F H+ VLA+CS YFK + +
Sbjct: 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVV-EGREFEVHQNVLASCSLYFKDLIQRSV 362
Query: 71 KE-----KFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKA 125
++ + K ++ LS + D+LE L+ + YT + I N ++LLEAA QF + K
Sbjct: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Query: 126 CERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLF 185
C FL + L NC+G+ + AE C EL ++ F EV QEE L IS + F+
Sbjct: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
Query: 186 ILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYL------KTA 238
+S +L+ EE + E VIKW D R + LL+ + + I P YL +
Sbjct: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Query: 239 LGLQRSC--LLTENKIRSLIYNALNPM-----HKEISQRSTATMYIIGGYYW-----HPL 286
+ +C L+ E K ++ +A M +S + ++GG L
Sbjct: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSL 602
Query: 287 SEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSES 346
V W+P N W A +P Y RE + V G NIY++GG + L VW Y S
Sbjct: 603 VAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESG--VTLADVWCYMSLL 660
Query: 347 DEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGV 406
D W M R H ++ G +Y LGG + E YD + +W +A + K V
Sbjct: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV 720
Query: 407 GNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFEN 466
+A A V IYV GG +QSY N WS I S +V
Sbjct: 721 HSAAATVCGGKIYVFGG--VNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNG 778
Query: 467 KLYLVGG-QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQ 525
++++GG T YDPE+ + M R C AV+++G IY TGG S+G L
Sbjct: 779 FVFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALG 838
Query: 526 SIEKYDPDLNKWEIVGNLPSAMRSHGCVCV 555
++E Y+P N W ++ ++P + HGCV +
Sbjct: 839 NMEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 245 bits (626), Expect = 7e-65
Identities = 175/570 (30%), Positives = 258/570 (45%), Gaps = 30/570 (5%)
Query: 11 YLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADM 70
Y F D HP + L FTD+ + G F H+ VLA+CS YFK + +
Sbjct: 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVV-EGREFEVHQNVLASCSLYFKDLIQRSV 362
Query: 71 KE-----KFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKA 125
++ + K ++ LS + D+LE L+ + YT + I N ++LLEAA QF + K
Sbjct: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Query: 126 CERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLF 185
C FL + L NC+G+ + AE C EL ++ F EV QEE L IS + F+
Sbjct: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
Query: 186 ILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYL------KTA 238
+S +L+ EE + E VIKW D R + LL+ + + I P YL +
Sbjct: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
Query: 239 LGLQRSC--LLTENKIRSLIYNALNPM-----HKEISQRSTATMYIIGGYYW-----HPL 286
+ +C L+ E K ++ +A M +S + ++GG L
Sbjct: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSL 602
Query: 287 SEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSES 346
V W+P N W A +P Y RE + V G NIY++GG + L VW Y S
Sbjct: 603 VAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESG--VTLADVWCYMSLL 660
Query: 347 DEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGV 406
D W M R H ++ G +Y LGG + E YD + +W +A + K V
Sbjct: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAV 720
Query: 407 GNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFEN 466
+A A V IYV GG +QSY N WS I S +V
Sbjct: 721 HSAAATVCGGKIYVFGG--VNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNG 778
Query: 467 KLYLVGG-QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQ 525
++++GG T YDPE+ + M R C AV+++G IY TGG S+G L
Sbjct: 779 FVFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALG 838
Query: 526 SIEKYDPDLNKWEIVGNLPSAMRSHGCVCV 555
++E Y+P N W ++ ++P + HGCV +
Sbjct: 839 NMEAYEPTTNTWTLLPHMPCPVFRHGCVVI 868
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 241 bits (616), Expect = 1e-63
Identities = 158/525 (30%), Positives = 244/525 (46%), Gaps = 26/525 (4%)
Query: 51 HRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSL 110
HR VLAACS YF AMFT DM E KI++ + L L++Y YT++IE+T+ NVQ L
Sbjct: 64 HRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVL 123
Query: 111 LEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVW 170
L AA LLQ + V++ C FL L NC+G+ +FA+ H C +L +++ F EV
Sbjct: 124 LPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVM 183
Query: 171 QQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDI 230
EEFL +SL++ ++S L+V EE + E VI W ++ E R+E + L+ ++ + +
Sbjct: 184 LGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPL 243
Query: 231 DPVYLKTALGLQRSCLLTENKIRSLIYNALN----PMHKEISQRSTAT-----------M 275
P + + + N + + A+ P+ + + ++ T M
Sbjct: 244 LPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVM 303
Query: 276 YIIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEA 335
++GG + V +D + W Q AE+P R GV + ++Y GG+ +
Sbjct: 304 IVVGGQAPKAIRSVECYDFEEDRWDQIAELPS-RRCRAGVVFMAGHVYAVGGF--NGSLR 360
Query: 336 LDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEK 395
+ TV +Y+ D+WT M R A L +YA+GG+ E Y +
Sbjct: 361 VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNE 420
Query: 396 WIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHP 455
W +A M + V+ +Y +GG+ G C V+ YN NEW +
Sbjct: 421 WFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQC-LSTVEQYNPATNEWIYVADMSTR 479
Query: 456 EYGLCSVPFENKLYLVGGQ-----TTITECYDPEQNEWREIAPMMERRMECGAVIMNGCI 510
G +LY GG E YDP N W+++A M R G +NG +
Sbjct: 480 RSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLL 539
Query: 511 YVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCV 555
YV GG S L S+E Y+P +KW ++ S RS+ V V
Sbjct: 540 YVVGGDDGS--CNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAV 582
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 236 bits (603), Expect = 3e-62
Identities = 173/566 (30%), Positives = 258/566 (45%), Gaps = 40/566 (7%)
Query: 16 STHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFK 75
+TH L++ + D+TL+ F HR VLAACS+YF AMFT+++ EK K
Sbjct: 13 NTHAKSILNSMNSLRKSNTLCDVTLRVEQKD-FPAHRIVLAACSDYFCAMFTSELSEKGK 71
Query: 76 NKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLD 135
+ + G+ +E L+++ YT + +T NVQ LL AA LLQ VK+AC FL LD
Sbjct: 72 PYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLD 131
Query: 136 IDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVW 195
NC+G+ FAE H C +L + + F EV Q EEF+ +S + ++ + V
Sbjct: 132 PSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVD 191
Query: 196 KEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYLKTAL--------GLQRSCL 246
EE + E VI W H + R E L NLL Y+ + + P Y+ + LQ L
Sbjct: 192 SEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDL 251
Query: 247 LTENK---IRSLIYNALNPMHKEISQRSTATMYIIGGY--YWHPLSEVHIWDPLTNVWIQ 301
+ E K +R + + + + + ++GG+ P+ V +DP T W
Sbjct: 252 VDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEW-- 309
Query: 302 GAEIPDYTRESYGV--TCLGPNIYVTGGY----RTDNIEALDTVWIYNSESD-EWTEGLP 354
+ +P TR+ V L IYV GGY R ++E LD Y ++ D W P
Sbjct: 310 -SFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLD----YTADEDGVWYSVAP 364
Query: 355 MLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVL 414
M R A TLG +Y GG+ E YDP ++W + +M A V
Sbjct: 365 MNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVA 424
Query: 415 HDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGG- 473
VIY +G GY G + V+ Y+ W+ +T G + +Y+VGG
Sbjct: 425 SGVIYCLG---GYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGF 481
Query: 474 ----QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEK 529
+ E Y+ + W + M R GA ++ G +Y G Y + L SIE
Sbjct: 482 DGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG--YDGNSLLSSIEC 539
Query: 530 YDPDLNKWEIVGNLPSAMRSHGCVCV 555
YDP ++ WE+V ++ R VCV
Sbjct: 540 YDPIIDSWEVVTSM-GTQRCDAGVCV 564
Score = 77.0 bits (188), Expect = 4e-14
Identities = 45/152 (29%), Positives = 77/152 (50%), Gaps = 12/152 (7%)
Query: 415 HDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGG- 473
++V+ V+GG + D V+ Y+ EWS + S + SV +++Y++GG
Sbjct: 280 NEVLLVVGGFGSQQSPI--DVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGY 337
Query: 474 ----QTTITECYD---PEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQS 526
+ + EC D E W +APM RR GA + IYV+GG+ S+ S
Sbjct: 338 DGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRH--TS 395
Query: 527 IEKYDPDLNKWEIVGNLPSAMRSHGCVCVYNV 558
+E+YDP++++W ++G++ +A G V V
Sbjct: 396 MERYDPNIDQWSMLGDMQTAREGAGLVVASGV 427
Score = 71.6 bits (174), Expect = 2e-12
Identities = 47/147 (31%), Positives = 68/147 (46%), Gaps = 4/147 (2%)
Query: 271 STATMYIIGGYYW-HPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYR 329
++ +Y +GGY + L+ V +DP T W + R GV L +IYV GG+
Sbjct: 424 ASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMAT-KRSGAGVALLNDHIYVVGGF- 481
Query: 330 TDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFY 389
D L +V YN +D WT M R Y A L G +YA+ GY + E Y
Sbjct: 482 -DGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECY 540
Query: 390 DPLKEKWIPIANMIKGVGNATACVLHD 416
DP+ + W + +M +A CVL +
Sbjct: 541 DPIIDSWEVVTSMGTQRCDAGVCVLRE 567
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 233 bits (595), Expect = 3e-61
Identities = 144/536 (26%), Positives = 260/536 (48%), Gaps = 30/536 (5%)
Query: 24 DAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGI 83
+ F L+G D+ ++ +G F H+ +L +CS+YF+A+FT+ K + GI
Sbjct: 27 EIFNELRLEGKLCDVVIKV-NGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGI 85
Query: 84 HHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMH 143
D+++ ++ YAYT + IT NV+ LL AAD + + + C FL L +DNCIG+
Sbjct: 86 SPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGIC 145
Query: 144 SFAEFHVCPELEKESRRILCSKFKE-VWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIE 202
F +++ CPEL +++ + F+E V EFLE+S+ + I+ + L+V +E+A+ E
Sbjct: 146 KFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFE 205
Query: 203 PVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRSCLLTENKIRSLIYNAL-- 260
++KW +HD +NR + + LL + + + + + + +I NAL
Sbjct: 206 AILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKA 265
Query: 261 -------NPMHKEISQRST------ATMYIIGGYY-WHPLSEVHIWDPLTNVWIQGAEIP 306
P + + + T A ++ IGG+ P + + +D + W+
Sbjct: 266 MYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEE 325
Query: 307 DYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVT 366
+ R +G L +Y+ GG+ D+++ ++V ++ W + PM + R Y
Sbjct: 326 ESPRAYHGAAYLKGYVYIIGGF--DSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTV 383
Query: 367 LGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCG 426
LG +YA+GG+ AE Y+P +W IA M + +A+A L+ +Y+ GG G
Sbjct: 384 LGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNG 443
Query: 427 YRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGG-----QTTITECY 481
C + + YN++ N+W++I G+ + + +Y VGG + E Y
Sbjct: 444 --NECLF-TAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAY 500
Query: 482 DPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537
P N WR I M R G +++ ++V GG++ T+ ++E YD ++W
Sbjct: 501 SPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTF--NVECYDEKTDEW 554
Score = 59.7 bits (143), Expect = 7e-09
Identities = 35/133 (26%), Positives = 70/133 (52%), Gaps = 17/133 (12%)
Query: 417 VIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLIT---SSPHPEYGLCSVPFENKLYLVGG 473
+++ IGG G GS T + +++Y++ + W +T SP +G + + +Y++GG
Sbjct: 292 ILFAIGGWSG--GSPT-NAIEAYDARADRWVNVTCEEESPRAYHGAAYL--KGYVYIIGG 346
Query: 474 QTTI-----TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYS-YSKGTYLQSI 527
++ + +DP + W ++APM RR ++ IY GG+ Y + L +
Sbjct: 347 FDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVR---LNTA 403
Query: 528 EKYDPDLNKWEIV 540
E+Y+P+ N+W ++
Sbjct: 404 ERYEPETNQWTLI 416
Score = 47.4 bits (111), Expect = 4e-05
Identities = 37/163 (22%), Positives = 66/163 (40%), Gaps = 8/163 (4%)
Query: 257 YNALNPMHKEISQRSTATMY----IIGGYYWHP-LSEVHIWDPLTNVWIQGAEIPDYTRE 311
+ + PMH++ S S T+Y I GG+ + L +++ +N W A + R
Sbjct: 413 WTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRS-RRS 471
Query: 312 SYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCV 371
GV G ++Y GG+ D L + Y+ ++ W M N R + +
Sbjct: 472 GIGVIAYGEHVYAVGGF--DGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLL 529
Query: 372 YALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVL 414
+ +GG+ E YD ++W +M + CV+
Sbjct: 530 FVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 232 bits (592), Expect = 6e-61
Identities = 160/514 (31%), Positives = 248/514 (48%), Gaps = 32/514 (6%)
Query: 49 HCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQ 108
H H+ VLA+ S YFKAMFT ++ EK ++++ I L+ +V YAYT + I++ V+
Sbjct: 47 HAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVE 106
Query: 109 SLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKE 168
SLL AA+LLQ V K C FL LD NCIG+ FAE + C +L + + +C F+
Sbjct: 107 SLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEA 166
Query: 169 VWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINI 228
V Q EEF E++ I+S L+V EE + + W +DV+ R + L LL+ + +
Sbjct: 167 VCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRL 226
Query: 229 DIDPVYLKTALGLQRSCLLTENKIRSLIYNALN----PMHKEISQRSTAT--------MY 276
+ V T L + + + L+ AL P H+ Q T +
Sbjct: 227 PLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLC 286
Query: 277 IIGGY--YWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIE 334
+GG + L V ++ P + WI A + + R +G+ L +YV GG T+
Sbjct: 287 AVGGKSGLFACLDSVEMYFPQNDSWIGLAPL-NIPRYEFGICVLDQKVYVIGGIATNVRP 345
Query: 335 AL------DTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEF 388
+ ++V +N +++ WT M +R V L G +YALGGY + + E
Sbjct: 346 GVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEK 405
Query: 389 YDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSL 448
Y P KW P+A M A VL +IY IGG+ G + V+ Y+ + W +
Sbjct: 406 YIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY----GPAHMNSVERYDPSKDSWEM 461
Query: 449 ITSSPHPEYGLCSVPFENKLYLVGGQTTIT-----ECYDPEQNEWREIAPMMERRMECGA 503
+ S +++VGG ++ E YDP QN+W PM E R GA
Sbjct: 462 VASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGA 521
Query: 504 VIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537
+++ +YV GG+S S +YL +++KYDP + W
Sbjct: 522 AVIDNYLYVVGGHSGS--SYLNTVQKYDPISDTW 553
Score = 79.0 bits (193), Expect = 1e-14
Identities = 51/170 (30%), Positives = 78/170 (45%), Gaps = 13/170 (7%)
Query: 384 EEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHC-GYRGSCTYDK----VQS 438
+ E Y P + WI +A + CVL +YVIGG R T K V+
Sbjct: 299 DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVEC 358
Query: 439 YNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQT-----TITECYDPEQNEWREIAP 493
+N D N W+ + L V +LY +GG E Y P+ +W+ +AP
Sbjct: 359 WNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAP 418
Query: 494 MMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNL 543
M R A +++G IY GGY + ++ S+E+YDP + WE+V ++
Sbjct: 419 MTTTRSCFAAAVLDGMIYAIGGYGPA---HMNSVERYDPSKDSWEMVASM 465
Score = 70.5 bits (171), Expect = 4e-12
Identities = 43/139 (30%), Positives = 67/139 (48%), Gaps = 21/139 (15%)
Query: 417 VIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLIT--SSPHPEYGLCSVPFENKLYLVGGQ 474
V+ +GG G D V+ Y + W + + P E+G+C + + K+Y++GG
Sbjct: 284 VLCAVGGKSGL--FACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVL--DQKVYVIGGI 339
Query: 475 TT-------------ITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKG 521
T EC++P+ N W + M E R G V++ G +Y GGY
Sbjct: 340 ATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQ-- 397
Query: 522 TYLQSIEKYDPDLNKWEIV 540
+YLQS+EKY P + KW+ V
Sbjct: 398 SYLQSVEKYIPKIRKWQPV 416
Score = 59.3 bits (142), Expect = 9e-09
Identities = 36/129 (27%), Positives = 62/129 (48%), Gaps = 3/129 (2%)
Query: 275 MYIIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIE 334
+Y IGGY ++ V +DP + W A + D R +GV + I+V GG+ + +
Sbjct: 435 IYAIGGYGPAHMNSVERYDPSKDSWEMVASMAD-KRIHFGVGVMLGFIFVVGGH--NGVS 491
Query: 335 ALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKE 394
L ++ Y+ ++WT PM R A + +Y +GG+ + + YDP+ +
Sbjct: 492 HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISD 551
Query: 395 KWIPIANMI 403
W+ A MI
Sbjct: 552 TWLDSAGMI 560
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 227 bits (579), Expect = 2e-59
Identities = 149/519 (28%), Positives = 254/519 (48%), Gaps = 37/519 (7%)
Query: 51 HRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSL 110
HR VL++ S+YF AMFT D++E + +IK+ G+ + L L+ YAYT ++E+ + N++ L
Sbjct: 188 HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECL 247
Query: 111 LEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVW 170
L A LLQ V +AC +FL++ L NC+G+ SFA+ C +L K + F EV
Sbjct: 248 LSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI 307
Query: 171 QQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID- 229
+ +EF+ + + +L+ ++++ EE I+ ++ W HD+E R + L LL+YI +
Sbjct: 308 RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPL 367
Query: 230 IDPVYLKTALGLQRSCLLTEN-KIRSLIYNALN----PMHKEISQ--------RSTATMY 276
+ P +L ++ + L ++ + + LI A+ P + + Q + T++
Sbjct: 368 LAPQFL---ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLF 424
Query: 277 IIGGY-YWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEA 335
+GG + + +D TN+W A + + R +GV L +YV GG D ++
Sbjct: 425 AVGGMDSTKGATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVLDDKLYVVGG--RDGLKT 481
Query: 336 LDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEK 395
L+TV YN ++ W+ PM R+ L G +YA+GG+ + E +DP +
Sbjct: 482 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 541
Query: 396 WIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHP 455
W +A M VL +Y +GG GS V+ ++ N+W+L
Sbjct: 542 WNFVATMSTPRSTVGVAVLSGKLYAVGGR---DGSSCLKSVECFDPHTNKWTLCAQMSKR 598
Query: 456 EYGLCSVPFENKLYLVGGQ--------TTITEC---YDPEQNEWREIAPMMERRMECGAV 504
G+ + LY +GG + +++C YDP+ + W +A M R G
Sbjct: 599 RGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC 658
Query: 505 IMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNL 543
++ +Y GGY YL ++E YDP N+W V L
Sbjct: 659 LLGDKLYAVGGYDGQ--AYLNTVEAYDPQTNEWTQVAPL 695
Score = 80.5 bits (197), Expect = 4e-15
Identities = 58/197 (29%), Positives = 85/197 (43%), Gaps = 17/197 (8%)
Query: 275 MYIIGGYY-WHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNI 333
MY +GG+ W L+ V WDP W A + R + GV L +Y GG D
Sbjct: 517 MYAVGGHDGWSYLNTVERWDPQARQWNFVATMST-PRSTVGVAVLSGKLYAVGG--RDGS 573
Query: 334 EALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEE-------- 385
L +V ++ +++WT M R T G +YA+GG+ APA
Sbjct: 574 SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGH--DAPASNLTSRLSDC 631
Query: 386 AEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINE 445
E YDP + W +A+M C+L D +Y +GG Y G + V++Y+ NE
Sbjct: 632 VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG---YDGQAYLNTVEAYDPQTNE 688
Query: 446 WSLITSSPHPEYGLCSV 462
W+ + G C V
Sbjct: 689 WTQVAPLCLGRAGACVV 705
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/139 (24%), Positives = 66/139 (47%), Gaps = 10/139 (7%)
Query: 418 IYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTI 477
++ +GG +G+ + +K Y+ N W+ + + ++KLY+VGG+ +
Sbjct: 423 LFAVGGMDSTKGATSIEK---YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 479
Query: 478 -----TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDP 532
ECY+P+ W + PM R G ++ G +Y GG+ +YL ++E++DP
Sbjct: 480 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD--GWSYLNTVERWDP 537
Query: 533 DLNKWEIVGNLPSAMRSHG 551
+W V + + + G
Sbjct: 538 QARQWNFVATMSTPRSTVG 556
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/100 (34%), Positives = 53/100 (53%), Gaps = 10/100 (10%)
Query: 275 MYIIGGY------YWHPLSE-VHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGG 327
+Y IGG+ LS+ V +DP T++W A + +R++ GV LG +Y GG
Sbjct: 611 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASM-SISRDAVGVCLLGDKLYAVGG 669
Query: 328 YRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTL 367
Y D L+TV Y+ +++EWT+ P+ R C VT+
Sbjct: 670 Y--DGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 707
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 227 bits (579), Expect = 2e-59
Identities = 149/519 (28%), Positives = 254/519 (48%), Gaps = 37/519 (7%)
Query: 51 HRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSL 110
HR VL++ S+YF AMFT D++E + +IK+ G+ + L L+ YAYT ++E+ + N++ L
Sbjct: 234 HRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECL 293
Query: 111 LEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVW 170
L A LLQ V +AC +FL++ L NC+G+ SFA+ C +L K + F EV
Sbjct: 294 LSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI 353
Query: 171 QQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID- 229
+ +EF+ + + +L+ ++++ EE I+ ++ W HD+E R + L LL+YI +
Sbjct: 354 RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPL 413
Query: 230 IDPVYLKTALGLQRSCLLTEN-KIRSLIYNALN----PMHKEISQ--------RSTATMY 276
+ P +L ++ + L ++ + + LI A+ P + + Q + T++
Sbjct: 414 LAPQFL---ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLF 470
Query: 277 IIGGY-YWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEA 335
+GG + + +D TN+W A + + R +GV L +YV GG D ++
Sbjct: 471 AVGGMDSTKGATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVLDDKLYVVGG--RDGLKT 527
Query: 336 LDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEK 395
L+TV YN ++ W+ PM R+ L G +YA+GG+ + E +DP +
Sbjct: 528 LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQ 587
Query: 396 WIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHP 455
W +A M VL +Y +GG GS V+ ++ N+W+L
Sbjct: 588 WNFVATMSTPRSTVGVAVLSGKLYAVGGR---DGSSCLKSVECFDPHTNKWTLCAQMSKR 644
Query: 456 EYGLCSVPFENKLYLVGGQ--------TTITEC---YDPEQNEWREIAPMMERRMECGAV 504
G+ + LY +GG + +++C YDP+ + W +A M R G
Sbjct: 645 RGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC 704
Query: 505 IMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNL 543
++ +Y GGY YL ++E YDP N+W V L
Sbjct: 705 LLGDKLYAVGGYDGQ--AYLNTVEAYDPQTNEWTQVAPL 741
Score = 80.5 bits (197), Expect = 4e-15
Identities = 58/197 (29%), Positives = 85/197 (43%), Gaps = 17/197 (8%)
Query: 275 MYIIGGYY-WHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNI 333
MY +GG+ W L+ V WDP W A + R + GV L +Y GG D
Sbjct: 563 MYAVGGHDGWSYLNTVERWDPQARQWNFVATMST-PRSTVGVAVLSGKLYAVGG--RDGS 619
Query: 334 EALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEE-------- 385
L +V ++ +++WT M R T G +YA+GG+ APA
Sbjct: 620 SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGH--DAPASNLTSRLSDC 677
Query: 386 AEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINE 445
E YDP + W +A+M C+L D +Y +GG Y G + V++Y+ NE
Sbjct: 678 VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG---YDGQAYLNTVEAYDPQTNE 734
Query: 446 WSLITSSPHPEYGLCSV 462
W+ + G C V
Sbjct: 735 WTQVAPLCLGRAGACVV 751
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/139 (24%), Positives = 66/139 (47%), Gaps = 10/139 (7%)
Query: 418 IYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTI 477
++ +GG +G+ + +K Y+ N W+ + + ++KLY+VGG+ +
Sbjct: 469 LFAVGGMDSTKGATSIEK---YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 525
Query: 478 -----TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDP 532
ECY+P+ W + PM R G ++ G +Y GG+ +YL ++E++DP
Sbjct: 526 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD--GWSYLNTVERWDP 583
Query: 533 DLNKWEIVGNLPSAMRSHG 551
+W V + + + G
Sbjct: 584 QARQWNFVATMSTPRSTVG 602
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/100 (34%), Positives = 53/100 (53%), Gaps = 10/100 (10%)
Query: 275 MYIIGGY------YWHPLSE-VHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGG 327
+Y IGG+ LS+ V +DP T++W A + +R++ GV LG +Y GG
Sbjct: 657 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASM-SISRDAVGVCLLGDKLYAVGG 715
Query: 328 YRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTL 367
Y D L+TV Y+ +++EWT+ P+ R C VT+
Sbjct: 716 Y--DGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 753
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 227 bits (579), Expect = 2e-59
Identities = 173/555 (31%), Positives = 242/555 (43%), Gaps = 52/555 (9%)
Query: 33 GLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLV 92
G D+TL+ F HR VLAA YF AMFT DM E +++I + G+ LE L+
Sbjct: 35 GKLCDVTLKIGDHK-FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALI 93
Query: 93 NYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCP 152
N+AY + I ++NVQSLL A LQ S+K AC FL L NC+G+ FAE +C
Sbjct: 94 NFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCA 153
Query: 153 ELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDV 212
L + + F EV EEFL + LE L ++SR L+V EE + E + W +D
Sbjct: 154 VLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDR 213
Query: 213 ENRIECLYNLLSYINIDI-DPVYLKTAL---GLQRSCLLTENKIRSLI-----YNALNPM 263
E R L LLS I + + P +L + L R C +K R L+ Y+ +
Sbjct: 214 EQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCC----HKCRDLVDEAKDYHLMPER 269
Query: 264 HKEISQRST---------ATMYIIGGY--YWHPLSEVHIWDPLTNVWIQGAEIPDYTRES 312
+ T +Y +GG L+ V ++DP+ N W + R
Sbjct: 270 RPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCW-ERCRPMTTARSR 328
Query: 313 YGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVY 372
GV + +Y GGY D L TV YN E+D WT M + R V L G +Y
Sbjct: 329 VGVAVVNGLLYAIGGY--DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIY 386
Query: 373 ALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCT 432
GGY + E Y P +KW + +M A V IYV GGH G +
Sbjct: 387 VCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQ---I 443
Query: 433 YDKVQSYNSDINEWSLITSSPHPEYGLC-------SVPFENKLYLVGGQ-----TTITEC 480
+ V+ YN W HP G+ + +K+++ GG +I E
Sbjct: 444 FSSVEHYNHHTATW-------HPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEM 496
Query: 481 YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIV 540
Y ++W I PM RR V G +Y GGY L S+E YDP+ + W +
Sbjct: 497 YSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDPETDCWTFM 554
Query: 541 GNLPSAMRSHGCVCV 555
+ G C+
Sbjct: 555 APMACHEGGVGVGCI 569
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 226 bits (577), Expect = 3e-59
Identities = 172/566 (30%), Positives = 247/566 (43%), Gaps = 51/566 (9%)
Query: 3 LKGQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYF 62
L +E + H D A GL DI L + I H+ VLA+CS YF
Sbjct: 59 LLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEI-RAHKVVLASCSPYF 117
Query: 63 KAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSV 122
AMFT +M E + + L I L+ LV +AYT++I + + NVQ+LL AA LLQ V
Sbjct: 118 HAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGV 177
Query: 123 KKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEK 182
+ AC +FL+ LD NC+G+ FA+ H C +L K + R + F +V + EEF+ + L++
Sbjct: 178 RDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQ 237
Query: 183 FLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQ 242
L ++S +L+V EE + V+ W HDV+ R + + L+ + + + L
Sbjct: 238 VLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPL----------LS 287
Query: 243 RSCLL----TENKIR------SLIYNALNPMHKEISQRST---------------ATMYI 277
R LL E+ +R L+ AL H QR ++
Sbjct: 288 RDFLLGHVDAESLVRHHPDCKDLLIEALK-FHLLPEQRGVLGTSRTRPRRCEGAGPVLFA 346
Query: 278 IGGYYWHPL-SEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEAL 336
+GG + + +D T+ W A + R GV +G +Y GGY D L
Sbjct: 347 VGGGSLFAIHGDCEAYDTRTDRWHVVASM-STRRARVGVAAVGNRLYAVGGY--DGTSDL 403
Query: 337 DTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKW 396
TV Y+ ++ W + M R L G +Y+ GGY + AE YDPL W
Sbjct: 404 ATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTW 463
Query: 397 IPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPE 456
+A M L +Y +G GY S V+ Y +N WS + S
Sbjct: 464 TSVAAMSTRRRYVRVATLDGNLYAVG---GYDSSSHLATVEKYEPQVNVWSPVASMLSRR 520
Query: 457 YGLCSVPFENKLYLVGGQ-----TTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIY 511
E LY+ GG E Y P+ W +APM RR V M+G +Y
Sbjct: 521 SSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLY 580
Query: 512 VTGGYSYSKGTYLQSIEKYDPDLNKW 537
GG S L SIEKY+P NKW
Sbjct: 581 AVGGNDGSSS--LNSIEKYNPRTNKW 604
Score = 98.2 bits (243), Expect = 2e-20
Identities = 71/239 (29%), Positives = 103/239 (43%), Gaps = 14/239 (5%)
Query: 275 MYIIGGYYW-HPLSEVHIWDPLTNVWIQGAEIPDYTRES-YGVTCLGPNIYVTGGYRTDN 332
+Y +GGY L+ V +DP+TN W E+ TR S GV L +Y GGY D
Sbjct: 391 LYAVGGYDGTSDLATVESYDPVTNTW--QPEVSMGTRRSCLGVAALHGLLYSAGGY--DG 446
Query: 333 IEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPL 392
L++ Y+ + WT M R Y TL G +YA+GGY + E Y+P
Sbjct: 447 ASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQ 506
Query: 393 KEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSS 452
W P+A+M+ +A VL +YV GG+ G+ + V+ Y+ W +
Sbjct: 507 VNVWSPVASMLSRRSSAGVAVLEGALYVAGGN---DGTSCLNSVERYSPKAGAWESVAPM 563
Query: 453 PHPEYGLCSVPFENKLYLVGG-----QTTITECYDPEQNEWREIAPMMERRMECGAVIM 506
V + LY VGG E Y+P N+W + M RR G ++
Sbjct: 564 NIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVL 622
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 226 bits (577), Expect = 3e-59
Identities = 154/552 (27%), Positives = 245/552 (44%), Gaps = 27/552 (4%)
Query: 23 LDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIKLSG 82
LD + D+TL G CHR +LA S YF AMF D E F +++L
Sbjct: 2 LDGLQRLRSQPKLADVTLLV-GGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
Query: 83 IHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGM 142
+ ++ LV++ YT ++ IT+ NV++L A L F SV+K C R+L + LD NC+G+
Sbjct: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
Query: 143 HSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVWKEEAIIE 202
F E + ++ L F+ V +++EFL++ E+ + L+ L V E++ +E
Sbjct: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
Query: 203 PVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRSCLLTENKIRSLIYNALNP 262
+++W HD + R L LLS +++D P L + R+ + +
Sbjct: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDG 240
Query: 263 MHKEISQRSTATMYIIGGYYWHP----------LSEVHIWDPLTNVWIQGAEIPDYTRES 312
+ Q+ + ++GG L ++ W+ + PDY +
Sbjct: 241 APLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWG 300
Query: 313 YGVTCLGPNIYVTGGYRTDNIEALDT--VWIYNSESDEWTEGLPMLNARYYHCAVTLGGC 370
+ + L NIYVTGG R + T W + + W PML R H + L G
Sbjct: 301 FSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGE 360
Query: 371 VYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGS 430
+Y +GG E E YDP + W P++ +K V N +A +Y++G +
Sbjct: 361 IYVIGG--TTLDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGS-----SA 413
Query: 431 CTYD--KVQSYNSDINEWSLITSSPHPEYGLCS---VPFENKLYLVGGQTTITECYDPEQ 485
C Y+ +Q YN + WS+I S P+Y L S +LYL+G T YDP
Sbjct: 414 CKYNALALQCYNPVTDAWSVIASPFLPKY-LSSPRCAALHGELYLIGDNTKKVYVYDPGA 472
Query: 486 NEWREIAPMMERRMECGAVIMNGCIYVTGG-YSYSKGTYLQSIEKYDPDLNKWEIVGNLP 544
N W+++ V + +YVTGG + +G Y +E YD + W G LP
Sbjct: 473 NLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHGALP 532
Query: 545 SAMRSHGCVCVY 556
HG V+
Sbjct: 533 RLWLYHGASTVF 544
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 224 bits (571), Expect = 2e-58
Identities = 148/518 (28%), Positives = 253/518 (48%), Gaps = 37/518 (7%)
Query: 52 RAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLL 111
R VL++ S+YF AMFT D++E + +IK+ G+ + L L+ YAYT ++E+ + N++ LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 112 EAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQ 171
A LLQ V +AC +FL++ L NC+G+ SFA+ C +L K + F EV +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 172 QEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-I 230
+EF+ + + +L+ ++++ EE I+ ++ W HD+E R + L LL+YI + +
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 231 DPVYLKTALGLQRSCLLTEN-KIRSLIYNALN----PMHKEISQ--------RSTATMYI 277
P +L ++ + L ++ + + LI A+ P + + Q + T++
Sbjct: 354 APQFL---ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFA 410
Query: 278 IGGY-YWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEAL 336
+GG + + +D TN+W A + + R +GV L +YV GG D ++ L
Sbjct: 411 VGGMDSTKGATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVLDDKLYVVGG--RDGLKTL 467
Query: 337 DTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKW 396
+TV YN ++ W+ PM R+ L G +YA+GG+ + E +DP +W
Sbjct: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW 527
Query: 397 IPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPE 456
+A M VL +Y +GG GS V+ ++ N+W+L
Sbjct: 528 NFVATMSTPRSTVGVAVLSGKLYAVGGR---DGSSCLKSVECFDPHTNKWTLCAQMSKRR 584
Query: 457 YGLCSVPFENKLYLVGGQ--------TTITEC---YDPEQNEWREIAPMMERRMECGAVI 505
G+ + LY +GG + +++C YDP+ + W +A M R G +
Sbjct: 585 GGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCL 644
Query: 506 MNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNL 543
+ +Y GGY YL ++E YDP N+W V L
Sbjct: 645 LGDKLYAVGGYDGQ--AYLNTVEAYDPQTNEWTQVAPL 680
Score = 80.5 bits (197), Expect = 4e-15
Identities = 58/197 (29%), Positives = 85/197 (43%), Gaps = 17/197 (8%)
Query: 275 MYIIGGYY-WHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNI 333
MY +GG+ W L+ V WDP W A + R + GV L +Y GG D
Sbjct: 502 MYAVGGHDGWSYLNTVERWDPQARQWNFVATMST-PRSTVGVAVLSGKLYAVGG--RDGS 558
Query: 334 EALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEE-------- 385
L +V ++ +++WT M R T G +YA+GG+ APA
Sbjct: 559 SCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGH--DAPASNLTSRLSDC 616
Query: 386 AEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINE 445
E YDP + W +A+M C+L D +Y +GG Y G + V++Y+ NE
Sbjct: 617 VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG---YDGQAYLNTVEAYDPQTNE 673
Query: 446 WSLITSSPHPEYGLCSV 462
W+ + G C V
Sbjct: 674 WTQVAPLCLGRAGACVV 690
Score = 65.5 bits (158), Expect = 1e-10
Identities = 34/139 (24%), Positives = 66/139 (47%), Gaps = 10/139 (7%)
Query: 418 IYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTI 477
++ +GG +G+ + +K Y+ N W+ + + ++KLY+VGG+ +
Sbjct: 408 LFAVGGMDSTKGATSIEK---YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 464
Query: 478 -----TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDP 532
ECY+P+ W + PM R G ++ G +Y GG+ +YL ++E++DP
Sbjct: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD--GWSYLNTVERWDP 522
Query: 533 DLNKWEIVGNLPSAMRSHG 551
+W V + + + G
Sbjct: 523 QARQWNFVATMSTPRSTVG 541
Score = 51.6 bits (122), Expect = 2e-06
Identities = 34/100 (34%), Positives = 53/100 (53%), Gaps = 10/100 (10%)
Query: 275 MYIIGGY------YWHPLSE-VHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGG 327
+Y IGG+ LS+ V +DP T++W A + +R++ GV LG +Y GG
Sbjct: 596 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASM-SISRDAVGVCLLGDKLYAVGG 654
Query: 328 YRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTL 367
Y D L+TV Y+ +++EWT+ P+ R C VT+
Sbjct: 655 Y--DGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 692
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 222 bits (566), Expect = 6e-58
Identities = 153/528 (28%), Positives = 257/528 (48%), Gaps = 32/528 (6%)
Query: 51 HRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSL 110
HR VL++ S+YF AMFT+D+ E + +IK+ GI + L LV +AYT +E+ + +++L
Sbjct: 226 HRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENL 285
Query: 111 LEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVW 170
L AA LLQ V + C FL++ L NC+G+ +FA+ C EL K + EV
Sbjct: 286 LAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVI 345
Query: 171 QQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDI 230
+ +EFL + E+ +L+ +++V EE I ++ W +D+++R L LL++I + +
Sbjct: 346 RNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPL 405
Query: 231 DPVYLKTAL---GLQRSCLLTENKIRSLIYNALNPMHKEISQ--------RSTATMYIIG 279
P + L L ++ L + I + L P + + Q + T+Y +G
Sbjct: 406 LPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVG 465
Query: 280 GYYWHP-LSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDT 338
G + + + +D TN+WIQ A + + R +GV + ++V GG D ++ L+T
Sbjct: 466 GMDNNKGATTIEKYDLRTNLWIQ-AGMMNGRRLQFGVAVIDDKLFVIGG--RDGLKTLNT 522
Query: 339 VWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIP 398
V YN ++ WT PM R+ L G +YA+GG+ + E +DP ++W
Sbjct: 523 VECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTF 582
Query: 399 IANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYG 458
+A+M L+ +Y +GG GS ++ Y+ N+W++ G
Sbjct: 583 VASMSIARSTVGVAALNGKLYSVGGR---DGSSCLSSMEYYDPHTNKWNMCAPMCKRRGG 639
Query: 459 LCSVPFENKLYLVGGQTT-----------ITECYDPEQNEWREIAPMMERRMECGAVIMN 507
+ + LY VGG E YDP+ + W +AP+ R G ++
Sbjct: 640 VGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLG 699
Query: 508 GCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCV 555
+Y GGY TYL ++E YDP N+W + +L + R+ CV V
Sbjct: 700 DRLYAVGGYDGQ--TYLNTMESYDPQTNEWTQMASL-NIGRAGACVVV 744
Score = 45.4 bits (106), Expect = 1e-04
Identities = 35/122 (28%), Positives = 54/122 (44%), Gaps = 14/122 (11%)
Query: 257 YNALNPMHKEISQRSTAT----MYIIGGY-------YWHPLSEVHIWDPLTNVWIQGAEI 305
+N PM K AT +Y +GG+ L V +DP T+ W A +
Sbjct: 627 WNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPL 686
Query: 306 PDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAV 365
R++ GV LG +Y GGY D L+T+ Y+ +++EWT+ + R C V
Sbjct: 687 -SMPRDAVGVCLLGDRLYAVGGY--DGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVV 743
Query: 366 TL 367
+
Sbjct: 744 VI 745
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 221 bits (562), Expect = 2e-57
Identities = 156/532 (29%), Positives = 254/532 (47%), Gaps = 40/532 (7%)
Query: 51 HRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSL 110
HR VL+A S+YF AMFT D+ E + ++++ G+ + L LV YAYT +++ + ++SL
Sbjct: 196 HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESL 255
Query: 111 LEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVW 170
L AA LLQ V C FL++ L NC+G+ SF + C EL + + F EV
Sbjct: 256 LAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVI 315
Query: 171 QQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDI 230
+ +EFL + + +L +++V EE I +++W HDV+NR L LLSYI + +
Sbjct: 316 KNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPL 375
Query: 231 DPVYLKTALGLQRSCLLT-ENKIRSLIYNALN----PMHKEISQ--------RSTATMYI 277
P L L+ S + T + + + L+ A+ P + + Q + +Y
Sbjct: 376 LPPQL--LADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYA 433
Query: 278 IGGY-YWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEAL 336
+GG + + +D TN W+ + + R +GV + +YV GG D ++ L
Sbjct: 434 VGGMDAMKGTTTIEKYDLRTNSWLHIGTM-NGRRLQFGVAVIDNKLYVVGG--RDGLKTL 490
Query: 337 DTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKW 396
+TV +N WT PM R+ TL G +YA+GG+ + E +DP +W
Sbjct: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQW 550
Query: 397 IPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPE 456
+A+M L++ +Y IGG GS ++ ++ N+WSL
Sbjct: 551 NYVASMSTPRSTVGVVALNNKLYAIGGR---DGSSCLKSMEYFDPHTNKWSLCAPMSKRR 607
Query: 457 YGLCSVPFENKLYLVGGQ--------TTITEC---YDPEQNEWREIAPMMERRMECGAVI 505
G+ + LY+VGG + +++C YDP+ + W +AP+ R
Sbjct: 608 GGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCP 667
Query: 506 MNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW--EIVGNLPSAMRSHGCVCV 555
+ +YV GG Y TYL ++E YD N+W E+ N+ R+ CV V
Sbjct: 668 LGDKLYVVGG--YDGHTYLNTVESYDAQRNEWKEEVPVNIG---RAGACVVV 714
Score = 67.4 bits (163), Expect = 3e-11
Identities = 39/145 (26%), Positives = 68/145 (46%), Gaps = 10/145 (6%)
Query: 418 IYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTI 477
+Y +GG +G+ T +K Y+ N W I + +NKLY+VGG+ +
Sbjct: 431 LYAVGGMDAMKGTTTIEK---YDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGL 487
Query: 478 -----TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDP 532
EC++P W + PM R G + G +Y GG+ +YL ++E++DP
Sbjct: 488 KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD--GWSYLNTVERWDP 545
Query: 533 DLNKWEIVGNLPSAMRSHGCVCVYN 557
+ +W V ++ + + G V + N
Sbjct: 546 EGRQWNYVASMSTPRSTVGVVALNN 570
Score = 44.7 bits (104), Expect = 2e-04
Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 14/117 (11%)
Query: 262 PMHKEISQRSTAT----MYIIGGY------YWHPLSE-VHIWDPLTNVWIQGAEIPDYTR 310
PM K AT +Y++GG+ + LS+ V +DP + W A + R
Sbjct: 602 PMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPL-SVPR 660
Query: 311 ESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTL 367
++ V LG +YV GGY D L+TV Y+++ +EW E +P+ R C V +
Sbjct: 661 DAVAVCPLGDKLYVVGGY--DGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 715
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 220 bits (561), Expect = 2e-57
Identities = 165/574 (28%), Positives = 259/574 (45%), Gaps = 43/574 (7%)
Query: 5 GQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCP----SGIIFHCHRAVLAACSN 60
G + Y +D H L D+TLQ F H+ VLA+ S
Sbjct: 48 GNRTFSYTLED--HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSP 105
Query: 61 YFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFL 120
FKAMFT ++E+ + + GIH ++E L+ +AYT+ I + ++ V ++ A + Q
Sbjct: 106 VFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQID 165
Query: 121 SVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISL 180
SV +AC FLV+ LD N IG+ +FAE C EL + +R + F EV +QEEF +S
Sbjct: 166 SVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSH 225
Query: 181 EKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINI-DIDPVYLKTAL 239
+ + ++SR +L+V E + I W +D E R + LL + + P +L+ L
Sbjct: 226 CQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQL 285
Query: 240 GLQRSCLLTENKIRSLIYNALNPMHKEIS-QRSTATM-----------YIIGGYYWHPLS 287
+ C + ++ R Y L + +E++ + T M Y GGY+ LS
Sbjct: 286 ---QKCEILQSDSRCKDY--LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLS 340
Query: 288 EVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTD-----NIEALDTVWIY 342
+ ++P W++ A++ R +G +Y GG + ALD Y
Sbjct: 341 YLEAYNPSDGTWLRLADL-QVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALD---CY 396
Query: 343 NSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANM 402
N +++W+ PM R + G +YA+GG E Y+P +++W +A M
Sbjct: 397 NPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM 456
Query: 403 IKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSV 462
+ VL+ ++Y +G G+ G+ + + Y + NEW +IT+ G
Sbjct: 457 LTRRIGVGVAVLNRLLYAVG---GFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVC 513
Query: 463 PFENKLYLVGG-----QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYS 517
N +Y GG Q E YD E W +APM RR G + G IYV GG
Sbjct: 514 VLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG-- 571
Query: 518 YSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHG 551
Y T+L S+E YDPD + W V + S G
Sbjct: 572 YDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVG 605
Score = 87.0 bits (214), Expect = 4e-17
Identities = 55/198 (27%), Positives = 92/198 (46%), Gaps = 10/198 (5%)
Query: 364 AVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGG 423
A +G +Y GGY + + E Y+P W+ +A++ CV+ ++Y +GG
Sbjct: 321 APKVGRLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGG 379
Query: 424 HCGYR-GSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQT-----TI 477
G+ + YN N+WS P + + +Y VGG
Sbjct: 380 RNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNS 439
Query: 478 TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537
E Y+PE++EW +APM+ RR+ G ++N +Y GG+ + L S E Y P+ N+W
Sbjct: 440 VERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEW 497
Query: 538 EIVGNLPSAMRSHGCVCV 555
++ + + +RS VCV
Sbjct: 498 RMITAM-NTIRSGAGVCV 514
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 220 bits (561), Expect = 2e-57
Identities = 165/574 (28%), Positives = 259/574 (45%), Gaps = 43/574 (7%)
Query: 5 GQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCP----SGIIFHCHRAVLAACSN 60
G + Y +D H L D+TLQ F H+ VLA+ S
Sbjct: 48 GNRTFSYTLED--HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSP 105
Query: 61 YFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFL 120
FKAMFT ++E+ + + GIH ++E L+ +AYT+ I + ++ V ++ A + Q
Sbjct: 106 VFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQID 165
Query: 121 SVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISL 180
SV +AC FLV+ LD N IG+ +FAE C EL + +R + F EV +QEEF +S
Sbjct: 166 SVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSH 225
Query: 181 EKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINI-DIDPVYLKTAL 239
+ + ++SR +L+V E + I W +D E R + LL + + P +L+ L
Sbjct: 226 CQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQL 285
Query: 240 GLQRSCLLTENKIRSLIYNALNPMHKEIS-QRSTATM-----------YIIGGYYWHPLS 287
+ C + ++ R Y L + +E++ + T M Y GGY+ LS
Sbjct: 286 ---QKCEILQSDSRCKDY--LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLS 340
Query: 288 EVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTD-----NIEALDTVWIY 342
+ ++P W++ A++ R +G +Y GG + ALD Y
Sbjct: 341 YLEAYNPSDGTWLRLADL-QVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALD---CY 396
Query: 343 NSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANM 402
N +++W+ PM R + G +YA+GG E Y+P +++W +A M
Sbjct: 397 NPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM 456
Query: 403 IKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSV 462
+ VL+ ++Y +G G+ G+ + + Y + NEW +IT+ G
Sbjct: 457 LTRRIGVGVAVLNRLLYAVG---GFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVC 513
Query: 463 PFENKLYLVGG-----QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYS 517
N +Y GG Q E YD E W +APM RR G + G IYV GG
Sbjct: 514 VLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG-- 571
Query: 518 YSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHG 551
Y T+L S+E YDPD + W V + S G
Sbjct: 572 YDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVG 605
Score = 87.0 bits (214), Expect = 4e-17
Identities = 55/198 (27%), Positives = 92/198 (46%), Gaps = 10/198 (5%)
Query: 364 AVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGG 423
A +G +Y GGY + + E Y+P W+ +A++ CV+ ++Y +GG
Sbjct: 321 APKVGRLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGG 379
Query: 424 HCGYR-GSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQT-----TI 477
G+ + YN N+WS P + + +Y VGG
Sbjct: 380 RNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNS 439
Query: 478 TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537
E Y+PE++EW +APM+ RR+ G ++N +Y GG+ + L S E Y P+ N+W
Sbjct: 440 VERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEW 497
Query: 538 EIVGNLPSAMRSHGCVCV 555
++ + + +RS VCV
Sbjct: 498 RMITAM-NTIRSGAGVCV 514
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 220 bits (561), Expect = 2e-57
Identities = 150/513 (29%), Positives = 246/513 (47%), Gaps = 35/513 (6%)
Query: 51 HRAVLAACSNYFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSL 110
HR VL+A S+YF AMFT D+ E + ++++ G+ + L LV YAYT +++ + ++SL
Sbjct: 196 HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESL 255
Query: 111 LEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVW 170
L AA LLQ V C FL++ L NC+G+ SF + C EL + + F EV
Sbjct: 256 LAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVI 315
Query: 171 QQEEFLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDI 230
+ +EFL + + +L +++V EE I +++W HDV+NR L LLSYI + +
Sbjct: 316 KNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPL 375
Query: 231 DPVYLKTALGLQRSCLLT-ENKIRSLIYNALN----PMHKEISQ--------RSTATMYI 277
P L L+ S + T + + + L+ A+ P + + Q + +Y
Sbjct: 376 LPPQL--LADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYA 433
Query: 278 IGGY-YWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEAL 336
+GG + + +D TN W+ + + R +GV + +YV GG D ++ L
Sbjct: 434 VGGMDAMKGTTTIEKYDLRTNSWLHIGTM-NGRRLQFGVAVIDNKLYVVGG--RDGLKTL 490
Query: 337 DTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKW 396
+TV +N WT PM R+ TL G +YA+GG+ + E +DP +W
Sbjct: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQW 550
Query: 397 IPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPE 456
+A+M L++ +Y IGG GS ++ ++ N+WSL
Sbjct: 551 NYVASMSTPRSTVGVVALNNKLYAIGGR---DGSSCLKSMEYFDPHTNKWSLCAPMSKRR 607
Query: 457 YGLCSVPFENKLYLVGGQ--------TTITEC---YDPEQNEWREIAPMMERRMECGAVI 505
G+ + LY+VGG + +++C YDP+ + W +AP+ R
Sbjct: 608 GGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCP 667
Query: 506 MNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWE 538
+ +YV GG Y TYL ++E YD N+W+
Sbjct: 668 LGDKLYVVGG--YDGHTYLNTVESYDAQRNEWK 698
Score = 79.3 bits (194), Expect = 8e-15
Identities = 57/195 (29%), Positives = 84/195 (43%), Gaps = 13/195 (6%)
Query: 369 GCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYR 428
G +YA+GG E YD W+ I M V+ + +YV+GG G +
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 429 GSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQT-----TITECYDP 483
T + V+ +N W+++ +GL E +Y VGG E +DP
Sbjct: 489 ---TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDP 545
Query: 484 EQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNL 543
E +W +A M R G V +N +Y GG S + L+S+E +DP NKW +
Sbjct: 546 EGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGS--SCLKSMEYFDPHTNKWSLCA-- 601
Query: 544 PSAMRSHGC-VCVYN 557
P + R G V YN
Sbjct: 602 PMSKRRGGVGVATYN 616
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 218 bits (554), Expect = 2e-56
Identities = 152/508 (29%), Positives = 236/508 (46%), Gaps = 30/508 (5%)
Query: 70 MKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERF 129
M E ++++ + L L++Y YT++I++T+ NVQ LL AA LLQ VKK C F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 130 LVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSR 189
L L NC+G+ +FA+ H C +L ++ F +V EEFL + +E+ ++S
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 190 KNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDP-VYL-----KTALGLQR 243
L++ EE + E VI W HD + R E + L+ ++ + + P YL + AL ++
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEAL-VKN 179
Query: 244 SCLLTENKIRSLIYNALNPMHKEISQRSTAT-----------MYIIGGYYWHPLSEVHIW 292
S + I ++ Y+ L P + I +S T M ++GG + V +
Sbjct: 180 SSACKDYLIEAMKYHLL-PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECY 238
Query: 293 DPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEG 352
D W Q AE+P R G+ + ++ GG+ + + TV Y+ D+WT
Sbjct: 239 DFKEERWHQVAELPS-RRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVKDQWTSV 295
Query: 353 LPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATAC 412
M + R A L G +YA+GG+ E Y+ +W +A M +
Sbjct: 296 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG 355
Query: 413 VLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVG 472
V+ ++Y +GG+ G C V+ YN+ NEW+ I G N LY VG
Sbjct: 356 VVGGLLYAVGGYDGASRQC-LSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVG 414
Query: 473 GQ-----TTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSI 527
G E YDP N WR++A M R G +NG +YV GG S L S+
Sbjct: 415 GHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGS--CNLASV 472
Query: 528 EKYDPDLNKWEIVGNLPSAMRSHGCVCV 555
E Y+P +KW +V + S RS+ V V
Sbjct: 473 EYYNPTTDKWTVVSSCMSTGRSYAGVTV 500
Score = 75.9 bits (185), Expect = 9e-14
Identities = 49/176 (27%), Positives = 79/176 (44%), Gaps = 9/176 (5%)
Query: 387 EFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEW 446
E YD +E+W +A + A + +++ +GG + GS V SY+ ++W
Sbjct: 236 ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG---FNGSLRVRTVDSYDPVKDQW 292
Query: 447 SLITSSPHPEYGLCSVPFENKLYLVGGQTTIT-----ECYDPEQNEWREIAPMMERRMEC 501
+ + + L + LY VGG T E Y+ + NEW +APM RR
Sbjct: 293 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 352
Query: 502 GAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCVCVYN 557
G ++ G +Y GGY + L ++E Y+ N+W + + S RS V V N
Sbjct: 353 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM-STRRSGAGVGVLN 407
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 214 bits (545), Expect = 2e-55
Identities = 152/577 (26%), Positives = 264/577 (45%), Gaps = 36/577 (6%)
Query: 5 GQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKA 64
G + ++F+ + DF + FY +G D+TL+ S +I CH+ VLA YF+A
Sbjct: 36 GDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLI-SCHKLVLACVIPYFRA 94
Query: 65 MFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKK 124
MF ++M E + I++ D +E LV + Y+S++ +T NVQ LL AA +LQ V +
Sbjct: 95 MFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAR 154
Query: 125 ACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFL 184
AC ++ H NC+ + +FAE H +L + + C F EV + E+F+ +S +
Sbjct: 155 ACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLH 214
Query: 185 FILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTALGLQRS 244
+LS +L++ E+ + IKW + ++ + L L+ + + + PV + +
Sbjct: 215 KLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQ 274
Query: 245 CLLTENKIRSLIYNALNPMHKEISQR----------------STATMYIIGGY--YWHPL 286
+ K R L+ A N H +S R + ++ +GG P
Sbjct: 275 IVKQNLKCRDLLDEARN-YHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPF 333
Query: 287 SEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSES 346
+ + N W G E+ + R GV + +Y GG+ D E L ++ +++ +
Sbjct: 334 RSIECYSINKNSWFFGPEM-NSRRRHVGVISVEGKVYAVGGH--DGNEHLGSMEMFDPLT 390
Query: 347 DEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGV 406
++W M R +LGG +YA+GG + E YD ++W +A M
Sbjct: 391 NKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPR 450
Query: 407 GNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFEN 466
G + L + +Y +GG+ G + V+ Y+ +++W + G
Sbjct: 451 GGVGSVALVNHVYAVGGN---DGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHG 507
Query: 467 KLYLVGG-----QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKG 521
LY+VGG + E YDP N+W +A + R G + G I+ GG ++
Sbjct: 508 CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGG--HNGN 565
Query: 522 TYLQSIEKYDPDLNKWEIVGNLPSAMRSHG---CVCV 555
YL ++E +DP LN+WE+VG++ G C C+
Sbjct: 566 AYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCL 602
Score = 50.4 bits (119), Expect = 4e-06
Identities = 39/148 (26%), Positives = 62/148 (41%), Gaps = 13/148 (8%)
Query: 417 VIYVIGGHCGYRGSCTYDKVQSYNSDINEWSL--ITSSPHPEYGLCSVPFENKLYLVGGQ 474
V++ +GG G + ++ Y+ + N W +S G+ SV E K+Y VGG
Sbjct: 319 VLFCVGGRGG--SGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISV--EGKVYAVGGH 374
Query: 475 TT-----ITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEK 529
E +DP N+W A M +R + G IY GG T +E+
Sbjct: 375 DGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLD--DNTCFNDVER 432
Query: 530 YDPDLNKWEIVGNLPSAMRSHGCVCVYN 557
YD + ++W V + + G V + N
Sbjct: 433 YDIESDQWSTVAPMNTPRGGVGSVALVN 460
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 207 bits (526), Expect = 3e-53
Identities = 152/565 (26%), Positives = 257/565 (45%), Gaps = 28/565 (4%)
Query: 12 LFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMK 71
LFKD D L + + TD+++ C CHR VLA+ S YF+AMF + +
Sbjct: 10 LFKDHDFSSDLLRQLNSLRQSRILTDVSI-CAGAREIPCHRNVLASSSPYFRAMFCSSFR 68
Query: 72 EKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLV 131
EK + K++L GI L+ +V+Y YT + I NV ++EAA +LQF + +AC +L
Sbjct: 69 EKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQ 128
Query: 132 RHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKN 191
L NC+GM +E C L+K++R + + F EV + E+ + L
Sbjct: 129 SQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDG 188
Query: 192 LSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYLKTALG----LQRS-- 244
L +EE + E ++ W HD++ R + L + + I P + + LQ S
Sbjct: 189 L-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPA 247
Query: 245 CLLTENKIRSLIYNALNP--------MHKEISQRSTATMYIIGGY--YWHPLSEVHIWDP 294
C + + +++ +H + ++GG +V ++
Sbjct: 248 CQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSK 307
Query: 295 LTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEAL--DTVWIYNSESDEWTEG 352
T W A++P ++ +T L +IYV GG + +L V+I++ + ++W G
Sbjct: 308 QTGQWQSLAKLPTRLYKASAIT-LHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLG 366
Query: 353 LPMLNARYYHCAVTLGGCVYALGGYRKGAP-AEEAEFYDPLKEKWIPIANMIKGVGNATA 411
PML ARY H + ++++GG +G E YD + W +A+M GV +
Sbjct: 367 EPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAV 426
Query: 412 CVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLV 471
V +Y+ GG + +Q Y+ N W + + +V ++ +V
Sbjct: 427 AVKDQRLYLFGGEDIMQNPVRL--IQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIV 484
Query: 472 GGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQ---SIE 528
GG T YDP+ N++ + A M +RRM GA +M +YVTGG + ++ S +
Sbjct: 485 GGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFD 544
Query: 529 KYDPDLNKWEIVGNLPSAMRSHGCV 553
YDP+ + W G LP + H C+
Sbjct: 545 CYDPETDTWTSQGQLPHKLFDHACL 569
Score = 47.8 bits (112), Expect = 3e-05
Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 8/94 (8%)
Query: 277 IIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYR--TD-NI 333
I+GGY L+ +DP +N +++ A++ D R +G T +G +YVTGG R TD NI
Sbjct: 483 IVGGYTRRILA----YDPQSNKFVKCADMKD-RRMHHGATVMGNKLYVTGGRRLTTDCNI 537
Query: 334 EALDTVWIYNSESDEWTEGLPMLNARYYHCAVTL 367
E + Y+ E+D WT + + + H +TL
Sbjct: 538 EDSASFDCYDPETDTWTSQGQLPHKLFDHACLTL 571
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 201 bits (512), Expect = 1e-51
Identities = 153/560 (27%), Positives = 249/560 (44%), Gaps = 80/560 (14%)
Query: 13 FKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGI-IFHCHRAVLAACSNYFKAMFTADMK 71
F +TH L F ++GL D+TL G IF HRA++A+ S+YFKAMFT MK
Sbjct: 27 FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMK 86
Query: 72 EKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLV 131
E+ IKL G++ L+ ++++ YT+++ + N+Q LEAA LQ L V C+ FL+
Sbjct: 87 EQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 146
Query: 132 RHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKN 191
+ +DNC+ + A + E++K + F + EFL++ E+ F+LS +
Sbjct: 147 SGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNS 206
Query: 192 LSVWKEEAIIEPVIKW-----------------------TAHDVENRIECL--------- 219
L E + + +W T D+ N ++ +
Sbjct: 207 LKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTC 266
Query: 220 ---------YNLLSYIN---------IDIDPVYLKTALGLQRSCLLTENKI-----RSLI 256
Y ++ Y+ I D +L T G+ R L+ ++ R+
Sbjct: 267 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQE 326
Query: 257 YNALNPMHKEISQRSTAT----MYIIGGYYWH------PLSEVHIWDPLTNVWIQGAEIP 306
+ +L PM Q A +Y++GG + + V +DP N W+Q A +
Sbjct: 327 WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 386
Query: 307 DYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVT 366
+ R + ++ L ++Y GG L TV YN +EW+ M Y H
Sbjct: 387 E-KRTFFHLSALKGHLYAVGGRSAAG--ELATVECYNPRMNEWSYVAKMSEPHYGHAGTV 443
Query: 367 LGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCG 426
GG +Y GG E +DP +KW+ A M G C + D +YVIGG+
Sbjct: 444 YGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGN-H 502
Query: 427 YRGSCTYDKVQS---YNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITEC--- 480
+RG+ YD V S Y+ +++W+ I + + + FENK+Y+VGG + C
Sbjct: 503 FRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVE 562
Query: 481 ----YDPEQNEWREIAPMME 496
YDPE++EW ++ + E
Sbjct: 563 IVQKYDPEKDEWHKVFDLPE 582
Score = 87.0 bits (214), Expect = 4e-17
Identities = 50/191 (26%), Positives = 92/191 (48%), Gaps = 10/191 (5%)
Query: 275 MYIIGGYYWH-PLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNI 333
+Y +GG L+ V ++P N W A++ + + T G +Y++GG D
Sbjct: 401 LYAVGGRSAAGELATVECYNPRMNEWSYVAKMSE-PHYGHAGTVYGGLMYISGGITHDTF 459
Query: 334 EALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAE-----EAEF 388
+ + + ++ ++D+W + PM R HC T+G +Y +GG ++ E+
Sbjct: 460 Q--NELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEY 517
Query: 389 YDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSL 448
Y P ++W PIA M++G + V + IYV+GG+ + C + VQ Y+ + +EW
Sbjct: 518 YSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY-SWNNRCMVEIVQKYDPEKDEWHK 576
Query: 449 ITSSPHPEYGL 459
+ P G+
Sbjct: 577 VFDLPESLGGI 587
Score = 53.1 bits (126), Expect = 6e-07
Identities = 32/126 (25%), Positives = 54/126 (42%), Gaps = 12/126 (9%)
Query: 435 KVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTITEC----------YDPE 484
+++ Y+ EW + P Y N LY+VGGQ+ +DP
Sbjct: 316 ELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPR 375
Query: 485 QNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLP 544
N+W ++A + E+R + G +Y GG S + L ++E Y+P +N+W V +
Sbjct: 376 YNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGE--LATVECYNPRMNEWSYVAKMS 433
Query: 545 SAMRSH 550
H
Sbjct: 434 EPHYGH 439
Score = 53.1 bits (126), Expect = 6e-07
Identities = 40/146 (27%), Positives = 63/146 (43%), Gaps = 7/146 (4%)
Query: 275 MYIIGGYYWHPL-SEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNI 333
MYI GG +E+ +DP T+ W+Q A + R + + +G +YV GG
Sbjct: 448 MYISGGITHDTFQNELMCFDPDTDKWMQKAPMTT-VRGLHCMCTVGDKLYVIGGNHFRGT 506
Query: 334 EALDTVW---IYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGY--RKGAPAEEAEF 388
D V Y+ D+WT ML + +Y +GGY E +
Sbjct: 507 SDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK 566
Query: 389 YDPLKEKWIPIANMIKGVGNATACVL 414
YDP K++W + ++ + +G AC L
Sbjct: 567 YDPEKDEWHKVFDLPESLGGIRACTL 592
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,084,933
Number of Sequences: 37866
Number of extensions: 997982
Number of successful extensions: 3305
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 1946
Number of HSP's gapped (non-prelim): 389
length of query: 558
length of database: 18,247,518
effective HSP length: 107
effective length of query: 451
effective length of database: 14,195,856
effective search space: 6402331056
effective search space used: 6402331056
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.