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Search of human proteins with 40018614
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40018614 DRE1 protein [Homo sapiens]
(600 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40018614 DRE1 protein [Homo sapiens] 1234 0.0
gi|109150407 kelch-like 6 [Homo sapiens] 502 e-142
gi|88196794 kelch-like 35 [Homo sapiens] 384 e-106
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 364 e-100
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 364 e-100
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 321 1e-87
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 321 1e-87
gi|166235129 kelch-like 3 [Homo sapiens] 320 2e-87
gi|55925608 kelch-like 21 [Homo sapiens] 315 1e-85
gi|40807500 kelch-like 20 [Homo sapiens] 314 1e-85
gi|194097389 kelch-like 38 [Homo sapiens] 302 5e-82
gi|11056006 kelch-like 12 [Homo sapiens] 302 7e-82
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 295 6e-80
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 295 6e-80
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 283 4e-76
gi|38194229 kelch-like 17 [Homo sapiens] 280 3e-75
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 280 4e-75
gi|55925604 kelch-like 18 [Homo sapiens] 278 8e-75
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 277 2e-74
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 277 2e-74
gi|40255071 kelch-like 23 [Homo sapiens] 273 3e-73
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 265 7e-71
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 265 7e-71
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 263 4e-70
gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 261 1e-69
gi|14780904 kelch-like 1 protein [Homo sapiens] 256 5e-68
gi|148664209 kelch-like 10 [Homo sapiens] 252 6e-67
gi|128485503 kelch-like 30 [Homo sapiens] 244 2e-64
gi|34101268 kelch-like 8 [Homo sapiens] 232 8e-61
gi|24308181 kelch-like 9 [Homo sapiens] 224 1e-58
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 1234 bits (3193), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 1 MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFR 60
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFR
Sbjct: 1 MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFR 60
Query: 61 DSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECF 120
DSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECF
Sbjct: 61 DSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECF 120
Query: 121 LQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL 180
LQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
Sbjct: 121 LQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL 180
Query: 181 KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRA 240
KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRA
Sbjct: 181 KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRA 240
Query: 241 VDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMS 300
VDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMS
Sbjct: 241 VDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMS 300
Query: 301 PRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCA 360
PRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCA
Sbjct: 301 PRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCA 360
Query: 361 LRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNR 420
LRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNR
Sbjct: 361 LRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNR 420
Query: 421 LSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETN 480
LSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETN
Sbjct: 421 LSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETN 480
Query: 481 SWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMS 540
SWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMS
Sbjct: 481 SWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMS 540
Query: 541 VCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL 600
VCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL
Sbjct: 541 VCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL 600
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 502 bits (1293), Expect = e-142
Identities = 258/542 (47%), Positives = 338/542 (62%), Gaps = 10/542 (1%)
Query: 60 RDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMEC 119
R TDVI+CV+ +EF CHR VL+A S+YFRAMFCND +E E + I G+ AE M
Sbjct: 66 RMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHT 125
Query: 120 FLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHS 179
L Y YT K IT +NVQ + E ++LFQ + DACA FL E L+P NC+GI R ADTHS
Sbjct: 126 LLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHS 185
Query: 180 LKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYR 239
L +L + +++ +Q F + EEFL+L D L + SD+L + +E VFE VM WV
Sbjct: 186 LDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRH 245
Query: 240 AVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMM 299
R LL +L +VRLPLL P YFV+TVE D LI+ PE + LL EAR YH+ GNE++
Sbjct: 246 KPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSGNEII 305
Query: 300 SPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKS----- 354
S RT+PR SEV +++GGC + F T C DP+ +AKLP
Sbjct: 306 SERTKPRMHEFQSEVFMIIGGCTKDERFVAEVT-CLDPLRRSRLEVAKLPLTEHELESEN 364
Query: 355 ----EYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVY 410
E+A L+N++ +SGG+ DVW YNS +N WI++ LN GRWRHKM VL GKVY
Sbjct: 365 KKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVY 424
Query: 411 VVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSD 470
V+GG+DG R+++VE YD F N W+E APL VSS A TS KL+VIGGGP+ +D
Sbjct: 425 VIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATD 484
Query: 471 KVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNT 530
K Q YDP TN W L+AA+P+ +CI AVS + IYV GG +A+Y Y P+ED W V
Sbjct: 485 KTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCLVTQL 544
Query: 531 FSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTI 590
+ +CG++ CN ++YI GGR E E T+LC+DP +T +PR VS+HG VTI
Sbjct: 545 SHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTI 604
Query: 591 HR 592
+
Sbjct: 605 RK 606
>gi|88196794 kelch-like 35 [Homo sapiens]
Length = 363
Score = 384 bits (987), Expect = e-106
Identities = 189/357 (52%), Positives = 240/357 (67%)
Query: 234 MRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHI 293
MRWV RR L LL HVRLPLL P YF++ VE D+L+Q EC LL EAR I
Sbjct: 1 MRWVRHDAPARRGQLRRLLEHVRLPLLAPAYFLEKVEADELLQACGECRPLLLEARACFI 60
Query: 294 LGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTK 353
LG E + RTRPRR +EVIVV+GGC+R G LP+ + Y P + W L LP +T+
Sbjct: 61 LGREAGALRTRPRRFMDLAEVIVVIGGCDRKGLLKLPFADAYHPESQRWTPLPSLPGYTR 120
Query: 354 SEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVG 413
SE+A CALRND+ VSGG INS DVW+++S L+ WI+VASL+KGRWRHKMAV+ G+++ VG
Sbjct: 121 SEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWRHKMAVVQGQLFAVG 180
Query: 414 GYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQ 473
G+DG RL SVE YD FSN W APL EAVSS AV SC GKLFVIGG +DKVQ
Sbjct: 181 GFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLFVIGGARQGGVNTDKVQ 240
Query: 474 SYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSR 533
+DP+ + W LR+ P ++RC+ AVSL + IYV GGL I+ YDP D W S
Sbjct: 241 CFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGLMSKIFTYDPGTDVWGEAAVLPSP 300
Query: 534 QENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTI 590
E+CG++VC+GK++ILGGR + GE+TD + +DP++ + ++ R S HGCVTI
Sbjct: 301 VESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSLQRCTSSHGCVTI 357
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 364 bits (935), Expect = e-100
Identities = 211/572 (36%), Positives = 317/572 (55%), Gaps = 19/572 (3%)
Query: 37 HEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFC 96
+EF D H +L+ N+ R ++ FTD+ I VEG+EF H+ VL++CS YF+ +
Sbjct: 304 YEFTD----PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQ 359
Query: 97 NDHRES----REML-VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVL 151
++S RE L + ++ + A+ +E L++VYTG + I + N + L E +S FQ
Sbjct: 360 RSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTF 419
Query: 152 RDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDE 211
C FLE+QL NCLG+ A+ L+ K FALQ F +V+ EE L + KD+
Sbjct: 420 CKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDD 479
Query: 212 LIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEV 271
I Y+ +D L EE+V+E V++W+ + R ELL VRLP +HP+Y + V+
Sbjct: 480 FIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
Query: 272 DQLIQNSPECYQLLHEARRYHILGN---EMMSPRTRPRRSTGYSEVIVVVGGCERVG--G 326
++LI++S C L++EA+RYH+L + EM +PRTRPR S G +EVIV+VGG + VG
Sbjct: 540 EELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
Query: 327 FNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGR---INSRDVWIYNSQ 383
+L C++P +W LA LP + + ++V + ++I +SGG + DVW Y S
Sbjct: 600 RSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSL 659
Query: 384 LNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEA 443
L+ W V+ + R RH V GK+Y +GG + VE YD+ +N+W VAPL +A
Sbjct: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKA 719
Query: 444 VSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNL 503
V S A T C GK++V GG + + +QSY P+TN+W + I + AV+LN
Sbjct: 720 VHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGF 779
Query: 504 IYVAGG-LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG-RRENGEATDT 561
+++ GG +A YDP + N ++ C V +GKIY GG G A
Sbjct: 780 VFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
Query: 562 ILCYDPATSIITGVAAMPRPVSYHGCVTIHRY 593
+ Y+P T+ T + MP PV HGCV I +Y
Sbjct: 840 MEAYEPTTNTWTLLPHMPCPVFRHGCVVIKKY 871
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 364 bits (935), Expect = e-100
Identities = 211/572 (36%), Positives = 317/572 (55%), Gaps = 19/572 (3%)
Query: 37 HEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFC 96
+EF D H +L+ N+ R ++ FTD+ I VEG+EF H+ VL++CS YF+ +
Sbjct: 304 YEFTD----PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQ 359
Query: 97 NDHRES----REML-VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVL 151
++S RE L + ++ + A+ +E L++VYTG + I + N + L E +S FQ
Sbjct: 360 RSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTF 419
Query: 152 RDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDE 211
C FLE+QL NCLG+ A+ L+ K FALQ F +V+ EE L + KD+
Sbjct: 420 CKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDD 479
Query: 212 LIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEV 271
I Y+ +D L EE+V+E V++W+ + R ELL VRLP +HP+Y + V+
Sbjct: 480 FIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
Query: 272 DQLIQNSPECYQLLHEARRYHILGN---EMMSPRTRPRRSTGYSEVIVVVGGCERVG--G 326
++LI++S C L++EA+RYH+L + EM +PRTRPR S G +EVIV+VGG + VG
Sbjct: 540 EELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
Query: 327 FNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGR---INSRDVWIYNSQ 383
+L C++P +W LA LP + + ++V + ++I +SGG + DVW Y S
Sbjct: 600 RSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSL 659
Query: 384 LNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEA 443
L+ W V+ + R RH V GK+Y +GG + VE YD+ +N+W VAPL +A
Sbjct: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKA 719
Query: 444 VSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNL 503
V S A T C GK++V GG + + +QSY P+TN+W + I + AV+LN
Sbjct: 720 VHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGF 779
Query: 504 IYVAGG-LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG-RRENGEATDT 561
+++ GG +A YDP + N ++ C V +GKIY GG G A
Sbjct: 780 VFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGN 839
Query: 562 ILCYDPATSIITGVAAMPRPVSYHGCVTIHRY 593
+ Y+P T+ T + MP PV HGCV I +Y
Sbjct: 840 MEAYEPTTNTWTLLPHMPCPVFRHGCVVIKKY 871
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 321 bits (822), Expect = 1e-87
Identities = 204/559 (36%), Positives = 278/559 (49%), Gaps = 19/559 (3%)
Query: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
H + ++ NE R L DV I E E HR VL+ACS YF AMF + ESR V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
I + + + YVYT ++++T ENVQ L + L Q+ ++ C +FLE QL P N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
CLGI+ FAD H+ L K +A Q F DV EEFL L +++ I SD+L I EE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
VFEAV+ WV D+R+ + L+ HVRLPLL Y VQ VE + L++NS C L E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 288 ARRYHILGNE----MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWK 343
A +YH+L E M S RTR R +++VVVGG + ECYD W
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKA---IRSVECYDFKEERWH 338
Query: 344 SLAKLPEFTKSEYAVCALRNDILVSG--GRINSRDVWIYNSQLNIWIRVASLNKGRWRHK 401
+A+LP V V G G + R V Y+ + W VA++ R
Sbjct: 339 QVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLG 398
Query: 402 MAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGG 461
AVL G +Y VGG+DG LSSVE Y+ SN W VAP+ SS V G L+ +GG
Sbjct: 399 AAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG 458
Query: 462 -GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKAIY 515
C V+ Y+ TN W A + + LNNL+Y GG + K++
Sbjct: 459 YDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVE 518
Query: 516 CYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEAT-DTILCYDPATSIITG 574
YDP + W V + + N G+ NG +Y++GG ++G ++ Y+P T T
Sbjct: 519 VYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLASVEYYNPTTDKWTV 576
Query: 575 VAA-MPRPVSYHGCVTIHR 592
V++ M SY G I +
Sbjct: 577 VSSCMSTGRSYAGVTVIDK 595
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 321 bits (822), Expect = 1e-87
Identities = 204/559 (36%), Positives = 278/559 (49%), Gaps = 19/559 (3%)
Query: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
H + ++ NE R L DV I E E HR VL+ACS YF AMF + ESR V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
I + + + YVYT ++++T ENVQ L + L Q+ ++ C +FLE QL P N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
CLGI+ FAD H+ L K +A Q F DV EEFL L +++ I SD+L I EE
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
VFEAV+ WV D+R+ + L+ HVRLPLL Y VQ VE + L++NS C L E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 288 ARRYHILGNE----MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWK 343
A +YH+L E M S RTR R +++VVVGG + ECYD W
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKA---IRSVECYDFKEERWH 334
Query: 344 SLAKLPEFTKSEYAVCALRNDILVSG--GRINSRDVWIYNSQLNIWIRVASLNKGRWRHK 401
+A+LP V V G G + R V Y+ + W VA++ R
Sbjct: 335 QVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLG 394
Query: 402 MAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGG 461
AVL G +Y VGG+DG LSSVE Y+ SN W VAP+ SS V G L+ +GG
Sbjct: 395 AAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGG 454
Query: 462 -GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKAIY 515
C V+ Y+ TN W A + + LNNL+Y GG + K++
Sbjct: 455 YDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVE 514
Query: 516 CYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEAT-DTILCYDPATSIITG 574
YDP + W V + + N G+ NG +Y++GG ++G ++ Y+P T T
Sbjct: 515 VYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLASVEYYNPTTDKWTV 572
Query: 575 VAA-MPRPVSYHGCVTIHR 592
V++ M SY G I +
Sbjct: 573 VSSCMSTGRSYAGVTVIDK 591
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 320 bits (820), Expect = 2e-87
Identities = 194/561 (34%), Positives = 287/561 (51%), Gaps = 21/561 (3%)
Query: 47 SHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREML 106
+H ++ NE R +L DV+I E E HR VL+ACS YF AMF D ES+
Sbjct: 31 AHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKK 90
Query: 107 VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPC 166
+EI + + + + Y+YT ++++T ENVQ L +SL Q+ +R C FL+ QL P
Sbjct: 91 IEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPT 150
Query: 167 NCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKE 226
NCLGI+ FAD H+ L + +A Q F +V EEFL L D++ I SD+L + E
Sbjct: 151 NCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSE 210
Query: 227 EMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLH 286
E VFEAV+ W+ + R + +L+ HVRLPLL +Y VQTVE + LI+N+ C L
Sbjct: 211 EKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLI 270
Query: 287 EARRYHILGNE----MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEW 342
EA +YH+L + + +PRT+PR +V++VVGG + ECYD W
Sbjct: 271 EAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKA---IRSVECYDFEEDRW 327
Query: 343 KSLAKLPEFTKSEYAVCALRNDILVSG---GRINSRDVWIYNSQLNIWIRVASLNKGRWR 399
+A+LP + V + + G G + R V +Y+ + W +AS+ + R
Sbjct: 328 DQIAELPS-RRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRST 386
Query: 400 HKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVI 459
AVL +Y VGG+DG L+SVE Y +N W VAP+ SS V GKL+ +
Sbjct: 387 LGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAV 446
Query: 460 GG-GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKA 513
GG C V+ Y+P TN W+ A + + L+ +Y GG + K+
Sbjct: 447 GGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKS 506
Query: 514 IYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEAT-DTILCYDPATSII 572
+ YDP + W V + + N G+ NG +Y++GG ++G ++ Y+P T
Sbjct: 507 VEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLASVEYYNPVTDKW 564
Query: 573 TGVAA-MPRPVSYHGCVTIHR 592
T + M SY G IH+
Sbjct: 565 TLLPTNMSTGRSYAGVAVIHK 585
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 315 bits (806), Expect = 1e-85
Identities = 188/559 (33%), Positives = 289/559 (51%), Gaps = 21/559 (3%)
Query: 44 SGSSHAENILQIFNEFRDSRLFTDVII-CVEGKEFPCHRAVLSACSSYFRAMFCNDHRES 102
S +HA ++L+ ++ R R F DV + G++FP HRAVL+A S YFRAMF RES
Sbjct: 13 SDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRES 72
Query: 103 REMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQ 162
R V ++G+ + ++ L + YTG+V ++ +N + L + L Q +++AC FL++Q
Sbjct: 73 RAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQ 132
Query: 163 LDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELV 222
LD NCL +Q FA+ S L + + F L+ ++ E+ L L+ Y+ D L
Sbjct: 133 LDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGA-EQLERLPLARLLRYLRDDGLC 191
Query: 223 IGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECY 282
+ KEE ++ +RWV R +LL VRLP + Y + VE + L+ P C
Sbjct: 192 VPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCL 251
Query: 283 QLLHEARRYHILGNEMMS----PRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPV 338
+LL EAR + + PR RPR STG +E++V+VGGC++ L +CY+P
Sbjct: 252 RLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQ-DCDELVTVDCYNPQ 310
Query: 339 TGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVASLNK 395
TG+W+ LA+ P+ Y++ AL NDI V+GG SR VW YNS +N W VA + K
Sbjct: 311 TGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLK 370
Query: 396 GRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGK 455
R H +VL G +YVV S E YD ++ W + P+ + + + T+C G+
Sbjct: 371 AREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGR 423
Query: 456 LFVIGGGPDDNTCSDKVQSYDPETNSWLL--RAAIPIAKRCITAVSLNNLIYVAGGLTKA 513
L+ IG T +Q YDP+T+ W L +P +LN L+Y +
Sbjct: 424 LYAIGSLAGKETM--VMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE 481
Query: 514 IYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIIT 573
+ Y+P + W + + ++V GK+Y+ GG E +D + YDP T +
Sbjct: 482 VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWS 541
Query: 574 GVAAMPRPVSYHGCVTIHR 592
V +P P +HG V+I R
Sbjct: 542 VVGRLPEPTFWHGSVSIFR 560
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 314 bits (805), Expect = 1e-85
Identities = 196/532 (36%), Positives = 279/532 (52%), Gaps = 17/532 (3%)
Query: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
H L++ N R R DV++ V K+ HR +LSACS YFRAMF + ESR+ V
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
Query: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
I I AME + + YT ++ + NVQ L + L Q++ +++AC +FL+ QLDP N
Sbjct: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Query: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
CLGI+ FADTHS + L F F++V + EEF+ L ++LID I SDEL + EE
Sbjct: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
Query: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
VF AVM WV ++ RRP L ++L HVRLPLL P + V TV D LI++ EC L+ E
Sbjct: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
Query: 288 ARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKS 344
A+ Y +L E M PRTRPR+ EV+ VGG G + E YDP T EW+
Sbjct: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGW--CSGDAISSVERYDPQTNEWRM 347
Query: 345 LAKLPEFTKSEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIR-VASLNKGRWRH 400
+A + + + V L + + GG S V Y+ + N W VA + R
Sbjct: 348 VASMSK-RRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSV 406
Query: 401 KMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIG 460
+AVL G +Y VGG DG + L+ VE YD N+WT VA + AV G L+ +G
Sbjct: 407 GVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVG 466
Query: 461 GGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL-----TKAIY 515
G D + + V+ Y+P+ N W A + ++ + ++IY GG +
Sbjct: 467 GS-DGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAE 525
Query: 516 CYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDP 567
Y+P + W V SR+ G++V NG++ +GG + TI +DP
Sbjct: 526 RYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGG-FDGTTYLKTIEVFDP 576
Score = 73.6 bits (179), Expect = 5e-13
Identities = 60/209 (28%), Positives = 90/209 (43%), Gaps = 13/209 (6%)
Query: 285 LHEARRYHILGNEMMS---PRTRPRRSTGYSEV---IVVVGGCERVGGFNLPYTECYDPV 338
L+ RY N+ S P + R S G + + + VGG + V N+ E YDP
Sbjct: 379 LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNI--VERYDPK 436
Query: 339 TGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIRVASLNK 395
+W +A + + AV L + GG + V YN Q N W +A +
Sbjct: 437 ENKWTRVASMST-RRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGT 495
Query: 396 GRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGK 455
R AV +Y VGG D LSS E Y+ +N+W+ V + S + G+
Sbjct: 496 RRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQ 555
Query: 456 LFVIGGGPDDNTCSDKVQSYDPETNSWLL 484
L +GG D T ++ +DP+ N+W L
Sbjct: 556 LMAVGGF-DGTTYLKTIEVFDPDANTWRL 583
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 302 bits (774), Expect = 5e-82
Identities = 194/579 (33%), Positives = 295/579 (50%), Gaps = 25/579 (4%)
Query: 29 MDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACS 88
MD +SL G F D S ++L+ N R SR+ TDV IC +E PCHR VL++ S
Sbjct: 1 MDEESLDGLLFKDHDFSS----DLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSS 56
Query: 89 SYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQI 148
YFRAMFC+ RE E V++ GI ++ + YVYTG+ I T+NV + E +S+ Q
Sbjct: 57 PYFRAMFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQF 116
Query: 149 SVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELD 208
L +AC+ +L+ QL P NCLG+ R ++ S +TL K + AL +F +V+ + EL
Sbjct: 117 PKLFEACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELC 176
Query: 209 KDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQT 268
EL DY+ D+ + G+EE VFEA+M W+ + R+ + EL VRL +HP +F
Sbjct: 177 ALELRDYL-GDDGLCGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHF 235
Query: 269 VEVDQLIQNSPECYQLLHEARR--YHILGNEM----MSPRTRPRRSTGYSEVIVVVGGCE 322
+ D L+Q+SP C +L A+R + + G + + PR S Y + ++++GG
Sbjct: 236 IANDALLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNS--YQDFLILLGG-R 292
Query: 323 RVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRN-----DILVSGGR-INSRD 376
+ Y TG+W+SLAKLP A+ R+ + VS GR + S +
Sbjct: 293 KDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHN 352
Query: 377 VWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGY-DGQNRLSSVECYDSFSNRWT 435
V+I++ +LN W + R+ H+ ++ +GG +GQ + S+E YDS N W
Sbjct: 353 VYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWE 412
Query: 436 EVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCI 495
+A + V PAV +L++ GG +Q Y NSW I C
Sbjct: 413 SMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCA 472
Query: 496 TAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRE- 554
AV L I + GG T+ I YDP + ++ + R+ + G +V K+Y+ GGRR
Sbjct: 473 PAVVLGERIVIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLT 532
Query: 555 ---NGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTI 590
N E + + CYDP T T +P + H C+T+
Sbjct: 533 TDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHACLTL 571
Score = 30.8 bits (68), Expect = 3.7
Identities = 13/47 (27%), Positives = 25/47 (53%)
Query: 546 IYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHR 592
+ +LGGR+++ + T +L Y T +A +P + +T+HR
Sbjct: 286 LILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHR 332
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 302 bits (773), Expect = 7e-82
Identities = 191/540 (35%), Positives = 282/540 (52%), Gaps = 28/540 (5%)
Query: 46 SSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREM 105
++HA++IL N R S DV + VE K+FP HR VL+ACS YF AMF ++ E +
Sbjct: 13 NTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKP 72
Query: 106 LVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDP 165
V+I G+ A ME L +VYT V +T ENVQ L + L Q+ ++ AC +FLE QLDP
Sbjct: 73 YVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDP 132
Query: 166 CNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGK 225
NCLGI+ FA+TH+ L + F+ + F +V QHEEF+ L + E+ I DE+ +
Sbjct: 133 SNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDS 192
Query: 226 EEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLL 285
EE VFEAV+ WV A R L LL +VR+PLL P Y ++ + I+ S +C L+
Sbjct: 193 EEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLV 252
Query: 286 HEARRYHI---LGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLP--YTECYDPVTG 340
EA+++H+ L ++M PRTR R G +EV++VVGG G P E YDP T
Sbjct: 253 DEAKKFHLRPELRSQMQGPRTRAR--LGANEVLLVVGG---FGSQQSPIDVVEKYDPKTQ 307
Query: 341 EWKSLAKLPEFTKSE--YAVCALRNDILVSGG-----RINSRDVWIYNS-QLNIWIRVAS 392
EW + LP T+ A +L + I V GG R++S + Y + + +W VA
Sbjct: 308 EW---SFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAP 364
Query: 393 LNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSC 452
+N R L +YV GG+DG R +S+E YD ++W+ + ++ A +
Sbjct: 365 MNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVA 424
Query: 453 VGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL-- 510
G ++ + GG D + V+ YDP T W + + LN+ IYV GG
Sbjct: 425 SGVIYCL-GGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDG 483
Query: 511 ---TKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDP 567
++ Y+ D W V + + + G +V G++Y + G + +I CYDP
Sbjct: 484 TAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG-YDGNSLLSSIECYDP 542
Score = 70.9 bits (172), Expect = 3e-12
Identities = 49/133 (36%), Positives = 65/133 (48%), Gaps = 8/133 (6%)
Query: 312 SEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRND-ILVSGG 370
S VI +GG + + N E YDP TG W ++ P TK A AL ND I V GG
Sbjct: 425 SGVIYCLGGYDGLNILNS--VEKYDPHTGHWTNVT--PMATKRSGAGVALLNDHIYVVGG 480
Query: 371 ---RINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECY 427
+ V YN + + W V S+ R VL G++Y + GYDG + LSS+ECY
Sbjct: 481 FDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECY 540
Query: 428 DSFSNRWTEVAPL 440
D + W V +
Sbjct: 541 DPIIDSWEVVTSM 553
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 295 bits (756), Expect = 6e-80
Identities = 187/579 (32%), Positives = 301/579 (51%), Gaps = 32/579 (5%)
Query: 18 DSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEF 77
+S T M+P T EFF +HAE + + + DVI+ +
Sbjct: 131 NSSQTLSSCHTMEP--CTSDEFFQ---ALNHAEQTFKKMENYLRHKQLCDVILVAGDRRI 185
Query: 78 PCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQ 137
P HR VLS+ S YF AMF ND RE+R+ +++ G+ ++ +QY YTG++++ +N++
Sbjct: 186 PAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 245
Query: 138 YLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFED 197
L T+ L Q+S + +AC KFL +QL P NCLGI+ FAD L N+ ++ F +
Sbjct: 246 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 305
Query: 198 VSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRL 257
V +++EF+ L E+ + SD++ I EE + A++ WV ++ RR L +LL ++RL
Sbjct: 306 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 365
Query: 258 PLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNE---MMSPRTRPRRSTGYSEV 314
PLL P F+ +E + L ++ EC +L+ EA +YH+L + SPRT+PR+ST
Sbjct: 366 PLLAPQ-FLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST--VGT 422
Query: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS 374
+ VGG + G E YD T W +A + + ++ V L + + V GGR
Sbjct: 423 LFAVGGMDSTKG--ATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVLDDKLYVVGGRDGL 479
Query: 375 R---DVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFS 431
+ V YN + W + ++ R +AVL G +Y VGG+DG + L++VE +D +
Sbjct: 480 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 539
Query: 432 NRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIA 491
+W VA + S+ V GKL+ + GG D ++C V+ +DP TN W L A +
Sbjct: 540 RQWNFVATMSTPRSTVGVAVLSGKLYAV-GGRDGSSCLKSVECFDPHTNKWTLCAQMSKR 598
Query: 492 KRCITAVSLNNLIYVAGG-----------LTKAIYCYDPVEDYWMHVQNTFSRQENCGMS 540
+ + + N L+Y GG L+ + YDP D W V + ++ G+
Sbjct: 599 RGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC 658
Query: 541 VCNGKIYILGGRRENGEA-TDTILCYDPATSIITGVAAM 578
+ K+Y +GG +G+A +T+ YDP T+ T VA +
Sbjct: 659 LLGDKLYAVGG--YDGQAYLNTVEAYDPQTNEWTQVAPL 695
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 295 bits (756), Expect = 6e-80
Identities = 187/579 (32%), Positives = 301/579 (51%), Gaps = 32/579 (5%)
Query: 18 DSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEF 77
+S T M+P T EFF +HAE + + + DVI+ +
Sbjct: 177 NSSQTLSSCHTMEP--CTSDEFFQ---ALNHAEQTFKKMENYLRHKQLCDVILVAGDRRI 231
Query: 78 PCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQ 137
P HR VLS+ S YF AMF ND RE+R+ +++ G+ ++ +QY YTG++++ +N++
Sbjct: 232 PAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 291
Query: 138 YLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFED 197
L T+ L Q+S + +AC KFL +QL P NCLGI+ FAD L N+ ++ F +
Sbjct: 292 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 351
Query: 198 VSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRL 257
V +++EF+ L E+ + SD++ I EE + A++ WV ++ RR L +LL ++RL
Sbjct: 352 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 411
Query: 258 PLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNE---MMSPRTRPRRSTGYSEV 314
PLL P F+ +E + L ++ EC +L+ EA +YH+L + SPRT+PR+ST
Sbjct: 412 PLLAPQ-FLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST--VGT 468
Query: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS 374
+ VGG + G E YD T W +A + + ++ V L + + V GGR
Sbjct: 469 LFAVGGMDSTKG--ATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVLDDKLYVVGGRDGL 525
Query: 375 R---DVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFS 431
+ V YN + W + ++ R +AVL G +Y VGG+DG + L++VE +D +
Sbjct: 526 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 585
Query: 432 NRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIA 491
+W VA + S+ V GKL+ + GG D ++C V+ +DP TN W L A +
Sbjct: 586 RQWNFVATMSTPRSTVGVAVLSGKLYAV-GGRDGSSCLKSVECFDPHTNKWTLCAQMSKR 644
Query: 492 KRCITAVSLNNLIYVAGG-----------LTKAIYCYDPVEDYWMHVQNTFSRQENCGMS 540
+ + + N L+Y GG L+ + YDP D W V + ++ G+
Sbjct: 645 RGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC 704
Query: 541 VCNGKIYILGGRRENGEA-TDTILCYDPATSIITGVAAM 578
+ K+Y +GG +G+A +T+ YDP T+ T VA +
Sbjct: 705 LLGDKLYAVGG--YDGQAYLNTVEAYDPQTNEWTQVAPL 741
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 283 bits (723), Expect = 4e-76
Identities = 184/556 (33%), Positives = 283/556 (50%), Gaps = 31/556 (5%)
Query: 46 SSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREM 105
SS+A+++L N R RLFTDV++ + FPCHRAVL+ACS YF AMF +ES++
Sbjct: 26 SSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDS 85
Query: 106 LVEI-NGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLD 164
V N I E +E L Y Y+ +V I EN + L E + + +RDACA+FLE+ L
Sbjct: 86 EVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLH 145
Query: 165 PCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIG 224
P NCLG+ +D H L+ L F+ + ++E+FL+L +D ++ + S+EL
Sbjct: 146 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETE 205
Query: 225 KEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQL 284
E +V+E+ + W+ + R L ELL VRL LL Y ++ V +++LI + ++
Sbjct: 206 DERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEI 265
Query: 285 LHEARR--YHILGNE--MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTG 340
+ EA R IL N+ + S RPR+ TG++ + ++GG F D
Sbjct: 266 VEEAIRCKLKILQNDGVVTSLCARPRK-TGHA--LFLLGG----QTFMCDKLYLVDQKAK 318
Query: 341 EWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN----SRDVWIYNSQLNIWIRVASLNKG 396
E A +P + E++ CA+ + ++GGR + S+DVW+Y++ W + A +
Sbjct: 319 EIIPKADIPS-PRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVA 377
Query: 397 RWRHKMAVLLGKVYVVGGYDGQN---------RLSSVECYDSFSNRWTEVAPLKEAVSSP 447
R+ H A L +YVVGG+ L VE YD N+WT VAPL+E VS+
Sbjct: 378 RFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNA 437
Query: 448 AVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVA 507
AV S KLF GG + KVQ YD N W + A P R A L N I++
Sbjct: 438 AVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIM 497
Query: 508 GGLTK----AIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTIL 563
GG T+ + Y ++ W V + +++ +C K+Y++GG + T+
Sbjct: 498 GGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGG-YFGIQRCKTLD 556
Query: 564 CYDPATSIITGVAAMP 579
CYDP + + +P
Sbjct: 557 CYDPTLDVWNSITTVP 572
Score = 57.0 bits (136), Expect = 5e-08
Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 3/125 (2%)
Query: 329 LPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG--RINSRDVWIYNSQLNI 386
LP +CYD W A P+ + A L N I + GG ++ + +NS+
Sbjct: 459 LPKVQCYDQCENRWTVPATCPQPWRYT-AAAVLGNQIFIMGGDTEFSACSAYKFNSETYQ 517
Query: 387 WIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSS 446
W +V + R K+YVVGGY G R +++CYD + W + + ++
Sbjct: 518 WTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIP 577
Query: 447 PAVTS 451
A S
Sbjct: 578 TAFVS 582
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/144 (25%), Positives = 55/144 (38%), Gaps = 14/144 (9%)
Query: 455 KLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAI 514
K+++ GG +N S V YD W A + +A+ + L + +YV GG T A
Sbjct: 341 KVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAAT 400
Query: 515 YC--------------YDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATD 560
C YDP + W V N + K++ GG + +
Sbjct: 401 GCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLP 460
Query: 561 TILCYDPATSIITGVAAMPRPVSY 584
+ CYD + T A P+P Y
Sbjct: 461 KVQCYDQCENRWTVPATCPQPWRY 484
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 280 bits (716), Expect = 3e-75
Identities = 175/536 (32%), Positives = 272/536 (50%), Gaps = 20/536 (3%)
Query: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
H + + R L D+++ V KE H+ VL++CS YF AMF N+ ESR+ V
Sbjct: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
Query: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
++ I +A++ +Q+ YT ++ + NVQ L +SL Q++ +RDAC KFL QLDP N
Sbjct: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
Query: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
CLGI+ FAD HS L + LQ F DV++ EEF+ L ++++ + SD L + EE
Sbjct: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
Query: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
V+ AV+ WV VD RR + L+ VRLPLL ++ + V+ + L+++ P+C LL E
Sbjct: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
Query: 288 ARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTEC--YDPVTGEW 342
A ++H+L + + + RTRPRR G V+ VGG G + +C YD T W
Sbjct: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG----GSLFAIHGDCEAYDTRTDRW 369
Query: 343 KSLAKLPEFTKSEYAVCALRNDILVSGGRINSRD---VWIYNSQLNIWIRVASLNKGRWR 399
+A + ++ V A+ N + GG + D V Y+ N W S+ R
Sbjct: 370 HVVASM-STRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSC 428
Query: 400 HKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVI 459
+A L G +Y GGYDG + L+S E YD + WT VA + V + G L+ +
Sbjct: 429 LGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAV 488
Query: 460 GGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKAI 514
GG D ++ V+ Y+P+ N W A++ + L +YVAGG ++
Sbjct: 489 -GGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSV 547
Query: 515 YCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATS 570
Y P W V R+ + +G +Y +GG + + ++I Y+P T+
Sbjct: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG-NDGSSSLNSIEKYNPRTN 602
Score = 89.7 bits (221), Expect = 7e-18
Identities = 61/184 (33%), Positives = 94/184 (51%), Gaps = 8/184 (4%)
Query: 325 GGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYA-VCALRNDILVSGGRINSRD---VWIY 380
G L E YDP+TG W S+A + T+ Y V L ++ GG +S V Y
Sbjct: 446 GASCLNSAERYDPLTGTWTSVAAMS--TRRRYVRVATLDGNLYAVGGYDSSSHLATVEKY 503
Query: 381 NSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPL 440
Q+N+W VAS+ R +AVL G +YV GG DG + L+SVE Y + W VAP+
Sbjct: 504 EPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPM 563
Query: 441 KEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSL 500
S+ + + G L+ +GG D ++ + ++ Y+P TN W + A+ +R V++
Sbjct: 564 NIRRSTHDLVAMDGWLYAVGGN-DGSSSLNSIEKYNPRTNKW-VAASCMFTRRSSVGVAV 621
Query: 501 NNLI 504
L+
Sbjct: 622 LELL 625
Score = 62.8 bits (151), Expect = 9e-10
Identities = 49/172 (28%), Positives = 74/172 (43%), Gaps = 9/172 (5%)
Query: 285 LHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFN----LPYTECYDPVTG 340
L+ A RY L S R Y V + G VGG++ L E Y+P
Sbjct: 450 LNSAERYDPLTGTWTSVAAMSTRRR-YVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVN 508
Query: 341 EWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIRVASLNKGR 397
W +A + +S V L + V+GG + V Y+ + W VA +N R
Sbjct: 509 VWSPVASMLS-RRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRR 567
Query: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAV 449
H + + G +Y VGG DG + L+S+E Y+ +N+W + + SS V
Sbjct: 568 STHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGV 619
Score = 53.5 bits (127), Expect = 5e-07
Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 7/128 (5%)
Query: 456 LFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLT---- 511
LF +GGG D ++YD T+ W + A++ + + ++ N +Y GG
Sbjct: 344 LFAVGGGSLFAIHGD-CEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSD 402
Query: 512 -KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATS 570
+ YDPV + W + +R+ G++ +G +Y GG + ++ YDP T
Sbjct: 403 LATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGY-DGASCLNSAERYDPLTG 461
Query: 571 IITGVAAM 578
T VAAM
Sbjct: 462 TWTSVAAM 469
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 280 bits (715), Expect = 4e-75
Identities = 189/574 (32%), Positives = 283/574 (49%), Gaps = 39/574 (6%)
Query: 32 KSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYF 91
+S TG +SH + +L N R +FTDV + + FPCHRAVL+A S YF
Sbjct: 12 RSSTGSMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYF 71
Query: 92 RAMFCNDHRESREMLVEINGIL-AEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISV 150
AMF + RESR+ V L E +E L + Y+ ++ I EN + L E + Q
Sbjct: 72 EAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHD 131
Query: 151 LRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKD 210
+RDA A+FLE+ L P NCLG+ +D H + L+ L FE V Q E+F L KD
Sbjct: 132 VRDAAAEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKD 191
Query: 211 ELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE 270
L+D I SDEL E +VFEA+++WV ++ R+ L ELL VRL LL + + V
Sbjct: 192 TLLDLISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVS 251
Query: 271 VDQLIQNSPECYQLLHEARR--YHILGNE--MMSPRTRPRRSTGYSEVIVVVGG----CE 322
+ L+ ++ EA R IL N+ + SP RPR++ ++++GG C+
Sbjct: 252 SEALLMADERTKLIMDEALRCKTRILQNDGVVTSPCARPRKA---GHTLLILGGQTFMCD 308
Query: 323 RVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN----SRDVW 378
++ D E A LP + E++ A+ + V+GGR + S+DVW
Sbjct: 309 KI--------YQVDHKAKEIIPKADLPS-PRKEFSASAIGCKVYVTGGRGSENGVSKDVW 359
Query: 379 IYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDG---------QNRLSSVECYDS 429
+Y++ W + A + R+ H A L +YVVGG+ L VE YD
Sbjct: 360 VYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDP 419
Query: 430 FSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIP 489
+N+W VAPL++ VS+ AV S KLFV GG KVQ YDP N W ++A P
Sbjct: 420 GANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECP 479
Query: 490 IAKRCITAVSLNNLIYVAGGLTK----AIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGK 545
R A L + I++ GG T+ + Y +D + W + + +++ +C K
Sbjct: 480 QPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNK 539
Query: 546 IYILGGRRENGEATDTILCYDPATSIITGVAAMP 579
+Y++GG + T+ CYDP + + +P
Sbjct: 540 LYVVGG-YFGTQRCKTLDCYDPTSDTWNCITTVP 572
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/149 (28%), Positives = 62/149 (41%), Gaps = 15/149 (10%)
Query: 451 SCVG-KLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG 509
S +G K++V GG +N S V YD W A + IA+ + L N +YV GG
Sbjct: 336 SAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGG 395
Query: 510 LT--------------KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRREN 555
T K + YDP + WM V N + K+++ GG +
Sbjct: 396 HTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIH 455
Query: 556 GEATDTILCYDPATSIITGVAAMPRPVSY 584
+ + CYDP+ + T A P+P Y
Sbjct: 456 RDMVSKVQCYDPSENRWTIKAECPQPWRY 484
Score = 58.2 bits (139), Expect = 2e-08
Identities = 32/121 (26%), Positives = 54/121 (44%), Gaps = 3/121 (2%)
Query: 333 ECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG--RINSRDVWIYNSQLNIWIRV 390
+CYDP W A+ P+ + A L + I + GG + + ++ + N W R+
Sbjct: 463 QCYDPSENRWTIKAECPQPWRYT-AAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRI 521
Query: 391 ASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVT 450
+ R K+YVVGGY G R +++CYD S+ W + + ++ A
Sbjct: 522 GDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFV 581
Query: 451 S 451
S
Sbjct: 582 S 582
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 278 bits (712), Expect = 8e-75
Identities = 175/537 (32%), Positives = 271/537 (50%), Gaps = 19/537 (3%)
Query: 55 IFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILA 114
+ E R DV + + +F HR VL+A YF AMF ND E ++ + + G+
Sbjct: 27 VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
Query: 115 EAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRF 174
A+E + + Y G + I +NVQ L +S Q+ ++DAC FL E+L P NCLG+++F
Sbjct: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
Query: 175 ADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVM 234
A+T L+ +F Q F +VS EEFL L +++++ + DEL + EE VFEA +
Sbjct: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206
Query: 235 RWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHIL 294
WV + R P L ELL+++RLPL P + V+ D L++ +C L+ EA+ YH++
Sbjct: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM 266
Query: 295 GN---EMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEF 351
+ + RTRPR T + +I VGG G +L E +DP+ W+ P
Sbjct: 267 PERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGD-SLNVVEVFDPIANCWERCR--PMT 323
Query: 352 TKSEYAVCALRNDILVS----GGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLG 407
T A+ N +L + G++ V YN + + W RV S+N R VL G
Sbjct: 324 TARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDG 383
Query: 408 KVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNT 467
++YV GGYDG + LSSVE Y +++WT V + S+ VT G+++V GG D
Sbjct: 384 QIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYV-SGGHDGLQ 442
Query: 468 CSDKVQSYDPETNSWLLRAAIPIAKRC-ITAVSLNNLIYVAGGLTKAIY-----CYDPVE 521
V+ Y+ T +W A + + KRC A SL + ++V GG + + Y V
Sbjct: 443 IFSSVEHYNHHTATWHPAAGM-LNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVA 501
Query: 522 DYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAM 578
D W + +R+ + G++Y +GG + ++ YDP T T +A M
Sbjct: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGG-YDGQSNLSSVEMYDPETDCWTFMAPM 557
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 277 bits (709), Expect = 2e-74
Identities = 182/506 (35%), Positives = 251/506 (49%), Gaps = 19/506 (3%)
Query: 101 ESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLE 160
ESR V I + + + YVYT ++++T ENVQ L + L Q+ ++ C +FLE
Sbjct: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
Query: 161 EQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDE 220
QL P NCLGI+ FAD H+ L K +A Q F DV EEFL L +++ I SD+
Sbjct: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
Query: 221 LVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPE 280
L I EE VFEAV+ WV D+R+ + L+ HVRLPLL Y VQ VE + L++NS
Sbjct: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
Query: 281 CYQLLHEARRYHILGNE----MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYD 336
C L EA +YH+L E M S RTR R +++VVVGG + ECYD
Sbjct: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKA---IRSVECYD 239
Query: 337 PVTGEWKSLAKLPEFTKSEYAVCALRNDILVSG--GRINSRDVWIYNSQLNIWIRVASLN 394
W +A+LP V V G G + R V Y+ + W VA++
Sbjct: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 299
Query: 395 KGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVG 454
R AVL G +Y VGG+DG LSSVE Y+ SN W VAP+ SS V G
Sbjct: 300 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 359
Query: 455 KLFVIGG-GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG---- 509
L+ +GG C V+ Y+ TN W A + + LNNL+Y GG
Sbjct: 360 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP 419
Query: 510 -LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEAT-DTILCYDP 567
+ K++ YDP + W V + + N G+ NG +Y++GG ++G ++ Y+P
Sbjct: 420 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLASVEYYNP 477
Query: 568 ATSIITGVAA-MPRPVSYHGCVTIHR 592
T T V++ M SY G I +
Sbjct: 478 TTDKWTVVSSCMSTGRSYAGVTVIDK 503
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 277 bits (708), Expect = 2e-74
Identities = 171/516 (33%), Positives = 277/516 (53%), Gaps = 27/516 (5%)
Query: 81 RAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLF 140
R VLS+ S YF AMF ND RE+R+ +++ G+ ++ +QY YTG++++ +N++ L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 141 ETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQ 200
T+ L Q+S + +AC KFL +QL P NCLGI+ FAD L N+ ++ F +V +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 201 HEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLL 260
++EF+ L E+ + SD++ I EE + A++ WV ++ RR L +LL ++RLPLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 261 HPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNE---MMSPRTRPRRSTGYSEVIVV 317
P F+ +E + L ++ EC +L+ EA +YH+L + SPRT+PR+ST +
Sbjct: 354 APQ-FLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKST--VGTLFA 410
Query: 318 VGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR-- 375
VGG + G E YD T W +A + + ++ V L + + V GGR +
Sbjct: 411 VGGMDSTKG--ATSIEKYDLRTNMWTPVANM-NGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
Query: 376 -DVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRW 434
V YN + W + ++ R +AVL G +Y VGG+DG + L++VE +D + +W
Sbjct: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW 527
Query: 435 TEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRC 494
VA + S+ V GKL+ + GG D ++C V+ +DP TN W L A + +
Sbjct: 528 NFVATMSTPRSTVGVAVLSGKLYAV-GGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGG 586
Query: 495 ITAVSLNNLIYVAGG-----------LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCN 543
+ + N L+Y GG L+ + YDP D W V + ++ G+ +
Sbjct: 587 VGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG 646
Query: 544 GKIYILGGRRENGEA-TDTILCYDPATSIITGVAAM 578
K+Y +GG +G+A +T+ YDP T+ T VA +
Sbjct: 647 DKLYAVGG--YDGQAYLNTVEAYDPQTNEWTQVAPL 680
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 273 bits (698), Expect = 3e-73
Identities = 177/559 (31%), Positives = 280/559 (50%), Gaps = 31/559 (5%)
Query: 46 SSHAENILQIFNEFRDSRLFTDVII-CVEGKEFPCHRAVLSACSSYFRAMFCNDHRESRE 104
S+H + L F F LFTD+ + C G F CHRAVL+ACS+YF+AMF D +E +
Sbjct: 16 STHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFK 75
Query: 105 MLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLD 164
++++GI + +E + Y YT +++IT NVQ L E + L Q ++ AC +FL LD
Sbjct: 76 NKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLD 135
Query: 165 PCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIG 224
NC+G+ FA+ H L + + F++V Q EEFLE+ ++ + + L +
Sbjct: 136 IDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSVW 195
Query: 225 KEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQL 284
KEE + E V++W V+ R L+ LL+++ + + P Y + + + C L
Sbjct: 196 KEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYLKTALGLQR------SC--L 246
Query: 285 LHEARRYHILGNEMMSPRTR--PRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEW 342
L E + ++ N ++P + +RST + ++GG L +DP+T W
Sbjct: 247 LTENKIRSLIYN-ALNPMHKEISQRSTA---TMYIIGG---YYWHPLSEVHIWDPLTNVW 299
Query: 343 KSLAKLPEFTKSEYAVCALRNDILVSGG----RINSRD-VWIYNSQLNIWIRVASLNKGR 397
A++P++T+ Y V L +I V+GG I + D VWIYNS+ + W + R
Sbjct: 300 IQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEWTEGLPMLNAR 359
Query: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCV--GK 455
+ H L G VY +GGY E YD +W +A + + V + T+CV
Sbjct: 360 YYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGN--ATACVLHDV 417
Query: 456 LFVIGG--GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKA 513
++VIGG G + DKVQSY+ + N W L + P + + +V N +Y+ GG T
Sbjct: 418 IYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTI 477
Query: 514 IYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG-RRENGEATDTILCYDPATSII 572
CYDP ++ W + R+ CG + NG IY+ GG G +I YDP +
Sbjct: 478 TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537
Query: 573 TGVAAMPRPVSYHGCVTIH 591
V +P + HGCV ++
Sbjct: 538 EIVGNLPSAMRSHGCVCVY 556
Score = 77.4 bits (189), Expect = 3e-14
Identities = 59/211 (27%), Positives = 88/211 (41%), Gaps = 18/211 (8%)
Query: 305 PRRSTGYSEVIVVVGGCE-RVGGFN----LPYTECYDPVTGEWKSLAKLPEFTKSEYAVC 359
P + Y V +GGC +GG+ E YDP+ +W +A + + + A C
Sbjct: 354 PMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATA-C 412
Query: 360 ALRNDILVSGGRINSRD------VWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVG 413
L + I V GG R V YNS +N W + S + K+Y+VG
Sbjct: 413 VLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVG 472
Query: 414 GYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGG-GPDDNTCSDKV 472
G + + ECYD N W E+AP+ E G ++V GG T +
Sbjct: 473 G-----QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSI 527
Query: 473 QSYDPETNSWLLRAAIPIAKRCITAVSLNNL 503
+ YDP+ N W + +P A R V + N+
Sbjct: 528 EKYDPDLNKWEIVGNLPSAMRSHGCVCVYNV 558
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 265 bits (678), Expect = 7e-71
Identities = 163/522 (31%), Positives = 262/522 (50%), Gaps = 24/522 (4%)
Query: 47 SHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREML 106
+HAE L+ + + DV++ P HR VLSA S YF AMF ND E+++
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 107 VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPC 166
V + G+ A+ +QY YTG +++ + ++ L + L Q++ + D C+ FL +QL P
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 167 NCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKE 226
NCLGI+ F D L + ++ F +V +++EFL L +E+ +CSD++ + E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 227 EMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLH 286
E +F A+M+WV V R+ L LL+++RLPLL P + +E + EC +LL
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLM 401
Query: 287 EARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWK 343
EA +YH+L M SPRT+PR+ST + VGG + + G E YD T W
Sbjct: 402 EAMKYHLLPERRSMMQSPRTKPRKST--VGALYAVGGMDAMKGTTT--IEKYDLRTNSWL 457
Query: 344 SLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVASLNKGRWRH 400
+ + + ++ V + N + V GGR + V +N IW + ++ R
Sbjct: 458 HIGTM-NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGL 516
Query: 401 KMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIG 460
+A L G +Y VGG+DG + L++VE +D +W VA + S+ V + KL+ I
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAI- 575
Query: 461 GGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG----------- 509
GG D ++C ++ +DP TN W L A + + + + N +YV GG
Sbjct: 576 GGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSR 635
Query: 510 LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG 551
L+ + YDP D W V ++ + K+Y++GG
Sbjct: 636 LSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG 677
Score = 76.6 bits (187), Expect = 6e-14
Identities = 64/198 (32%), Positives = 93/198 (46%), Gaps = 18/198 (9%)
Query: 298 MMSPRTRPRRSTGYSEVIVVVGGCERVGGFN----LPYTECYDPVTGEWKSLAKLPEFTK 353
+M P + R G V + G VGG + L E +DP +W +A + +
Sbjct: 505 VMPPMSTHRHGLG---VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMST-PR 560
Query: 354 SEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVY 410
S V AL N + GGR S + + ++ N W A ++K R +A G +Y
Sbjct: 561 STVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY 620
Query: 411 VVGGYDGQ-----NRLSS-VECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPD 464
VVGG+D +RLS VE YD + W+ VAPL + AV KL+V+GG D
Sbjct: 621 VVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY-D 679
Query: 465 DNTCSDKVQSYDPETNSW 482
+T + V+SYD + N W
Sbjct: 680 GHTYLNTVESYDAQRNEW 697
Score = 62.8 bits (151), Expect = 9e-10
Identities = 45/194 (23%), Positives = 82/194 (42%), Gaps = 10/194 (5%)
Query: 406 LGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDD 465
+G +Y VGG D +++E YD +N W + + V KL+V+GG
Sbjct: 428 VGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGL 487
Query: 466 NTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKAIYCYDPV 520
T + V+ ++P W + + + + +L +Y GG + +DP
Sbjct: 488 KTLNT-VECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPE 546
Query: 521 EDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPR 580
W +V + + + G+ N K+Y +GG R+ ++ +DP T+ + A M +
Sbjct: 547 GRQWNYVASMSTPRSTVGVVALNNKLYAIGG-RDGSSCLKSMEYFDPHTNKWSLCAPMSK 605
Query: 581 PVSYHGCVTIHRYN 594
G V + YN
Sbjct: 606 ---RRGGVGVATYN 616
Score = 53.1 bits (126), Expect = 7e-07
Identities = 50/185 (27%), Positives = 78/185 (42%), Gaps = 17/185 (9%)
Query: 266 VQTVEVDQLIQNSPECYQLLHEARRYHILGNEM--MSPRTRPRRSTGY---SEVIVVVGG 320
V T+E + + L+ R+ G + ++ + PR + G + + +GG
Sbjct: 518 VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG 577
Query: 321 CERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN------- 373
R G L E +DP T +W A + + + V + V GG
Sbjct: 578 --RDGSSCLKSMEYFDPHTNKWSLCAPMSK-RRGGVGVATYNGFLYVVGGHDAPASNHCS 634
Query: 374 --SRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFS 431
S V Y+ + + W VA L+ R + L K+YVVGGYDG L++VE YD+
Sbjct: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQR 694
Query: 432 NRWTE 436
N W E
Sbjct: 695 NEWKE 699
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 265 bits (678), Expect = 7e-71
Identities = 163/522 (31%), Positives = 262/522 (50%), Gaps = 24/522 (4%)
Query: 47 SHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREML 106
+HAE L+ + + DV++ P HR VLSA S YF AMF ND E+++
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEE 222
Query: 107 VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPC 166
V + G+ A+ +QY YTG +++ + ++ L + L Q++ + D C+ FL +QL P
Sbjct: 223 VRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS 282
Query: 167 NCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKE 226
NCLGI+ F D L + ++ F +V +++EFL L +E+ +CSD++ + E
Sbjct: 283 NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDE 342
Query: 227 EMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLH 286
E +F A+M+WV V R+ L LL+++RLPLL P + +E + EC +LL
Sbjct: 343 ETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLM 401
Query: 287 EARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWK 343
EA +YH+L M SPRT+PR+ST + VGG + + G E YD T W
Sbjct: 402 EAMKYHLLPERRSMMQSPRTKPRKST--VGALYAVGGMDAMKGTTT--IEKYDLRTNSWL 457
Query: 344 SLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVASLNKGRWRH 400
+ + + ++ V + N + V GGR + V +N IW + ++ R
Sbjct: 458 HIGTM-NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGL 516
Query: 401 KMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIG 460
+A L G +Y VGG+DG + L++VE +D +W VA + S+ V + KL+ I
Sbjct: 517 GVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAI- 575
Query: 461 GGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG----------- 509
GG D ++C ++ +DP TN W L A + + + + N +YV GG
Sbjct: 576 GGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSR 635
Query: 510 LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGG 551
L+ + YDP D W V ++ + K+Y++GG
Sbjct: 636 LSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG 677
Score = 79.3 bits (194), Expect = 9e-15
Identities = 69/218 (31%), Positives = 100/218 (45%), Gaps = 20/218 (9%)
Query: 298 MMSPRTRPRRSTGYSEVIVVVGGCERVGGFN----LPYTECYDPVTGEWKSLAKLPEFTK 353
+M P + R G V + G VGG + L E +DP +W +A + +
Sbjct: 505 VMPPMSTHRHGLG---VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMST-PR 560
Query: 354 SEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVY 410
S V AL N + GGR S + + ++ N W A ++K R +A G +Y
Sbjct: 561 STVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY 620
Query: 411 VVGGYDGQ-----NRLSS-VECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPD 464
VVGG+D +RLS VE YD + W+ VAPL + AV KL+V+GG D
Sbjct: 621 VVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY-D 679
Query: 465 DNTCSDKVQSYDPETNSWLLRAAIPI--AKRCITAVSL 500
+T + V+SYD + N W + I A C+ V L
Sbjct: 680 GHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVVKL 717
Score = 62.8 bits (151), Expect = 9e-10
Identities = 45/194 (23%), Positives = 82/194 (42%), Gaps = 10/194 (5%)
Query: 406 LGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDD 465
+G +Y VGG D +++E YD +N W + + V KL+V+GG
Sbjct: 428 VGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGL 487
Query: 466 NTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKAIYCYDPV 520
T + V+ ++P W + + + + +L +Y GG + +DP
Sbjct: 488 KTLNT-VECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPE 546
Query: 521 EDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPR 580
W +V + + + G+ N K+Y +GG R+ ++ +DP T+ + A M +
Sbjct: 547 GRQWNYVASMSTPRSTVGVVALNNKLYAIGG-RDGSSCLKSMEYFDPHTNKWSLCAPMSK 605
Query: 581 PVSYHGCVTIHRYN 594
G V + YN
Sbjct: 606 ---RRGGVGVATYN 616
Score = 55.5 bits (132), Expect = 1e-07
Identities = 51/189 (26%), Positives = 80/189 (42%), Gaps = 17/189 (8%)
Query: 266 VQTVEVDQLIQNSPECYQLLHEARRYHILGNEM--MSPRTRPRRSTGY---SEVIVVVGG 320
V T+E + + L+ R+ G + ++ + PR + G + + +GG
Sbjct: 518 VATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG 577
Query: 321 CERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN------- 373
R G L E +DP T +W A + + + V + V GG
Sbjct: 578 --RDGSSCLKSMEYFDPHTNKWSLCAPMSK-RRGGVGVATYNGFLYVVGGHDAPASNHCS 634
Query: 374 --SRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFS 431
S V Y+ + + W VA L+ R + L K+YVVGGYDG L++VE YD+
Sbjct: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQR 694
Query: 432 NRWTEVAPL 440
N W E P+
Sbjct: 695 NEWKEEVPV 703
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 263 bits (671), Expect = 4e-70
Identities = 177/553 (32%), Positives = 267/553 (48%), Gaps = 32/553 (5%)
Query: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
H+E +LQ N R D+I+ V + H+ VL++ S YF+AMF + E V
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
E I A++ ++Y YTG V I+ + V+ L ++L QI ++ C FLE QLDP N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
C+GI RFA+T+ + L+ + Q FE V Q EEF EL +L + + +D L + EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
VF A+ W+ V R+ L +LL VRLPLL + + E + LI++ C LL+E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 288 ARRYHILGNEMMSPR----TRPRRSTGYSEVIVVVGGCERVGGFN-LPYTECYDPVTGEW 342
A +YH + +S + TRPR + +V+ VGG + G F L E Y P W
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCA---PKVLCAVGG--KSGLFACLDSVEMYFPQNDSW 311
Query: 343 KSLAKLPEFTKSEYAVCALRNDILVSGG-----------RINSRDVWIYNSQLNIWIRVA 391
LA L + E+ +C L + V GG R + V +N N W +
Sbjct: 312 IGLAPL-NIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
Query: 392 SLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTS 451
+N+ R + VL G++Y +GGYDGQ+ L SVE Y +W VAP+ S A
Sbjct: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
Query: 452 CVGKLFVIGG-GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL 510
G ++ IGG GP + V+ YDP +SW + A++ + + I+V GG
Sbjct: 431 LDGMIYAIGGYGP---AHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH 487
Query: 511 T-----KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCY 565
+I YDP ++ W + + G +V + +Y++GG +T+ Y
Sbjct: 488 NGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG-HSGSSYLNTVQKY 546
Query: 566 DPATSIITGVAAM 578
DP + A M
Sbjct: 547 DPISDTWLDSAGM 559
>gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 702
Score = 261 bits (668), Expect = 1e-69
Identities = 149/402 (37%), Positives = 228/402 (56%), Gaps = 17/402 (4%)
Query: 37 HEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFC 96
+EF D H +L+ N+ R ++ FTD+ I VEG+EF H+ VL++CS YF+ +
Sbjct: 304 YEFTD----PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQ 359
Query: 97 NDHRES----REML-VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVL 151
++S RE L + ++ + A+ +E L++VYTG + I + N + L E +S FQ
Sbjct: 360 RSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTF 419
Query: 152 RDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDE 211
C FLE+QL NCLG+ A+ L+ K FALQ F +V+ EE L + KD+
Sbjct: 420 CKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDD 479
Query: 212 LIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEV 271
I Y+ +D L EE+V+E V++W+ + R ELL VRLP +HP+Y + V+
Sbjct: 480 FIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
Query: 272 DQLIQNSPECYQLLHEARRYHILGN---EMMSPRTRPRRSTGYSEVIVVVGGCERVG--G 326
++LI++S C L++EA+RYH+L + EM +PRTRPR S G +EVIV+VGG + VG
Sbjct: 540 EELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
Query: 327 FNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGR---INSRDVWIYNSQ 383
+L C++P +W LA LP + + ++V + ++I +SGG + DVW Y S
Sbjct: 600 RSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSL 659
Query: 384 LNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVE 425
L+ W V+ + R RH V GK+Y +GG + VE
Sbjct: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
Score = 30.0 bits (66), Expect = 6.3
Identities = 30/114 (26%), Positives = 54/114 (47%), Gaps = 10/114 (8%)
Query: 401 KMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPL----KEAVSSPAVTSCVGKL 456
++ VL+G +VG Q L +V C++ +N+W +A L +E S V S +
Sbjct: 584 EVIVLVGGRQMVGMT--QRSLVAVTCWNPQNNKWYPLASLPFYDREFFS---VVSAGDNI 638
Query: 457 FVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL 510
++ GG T +D V Y ++W L + + + + ++ + IY GGL
Sbjct: 639 YLSGGMESGVTLAD-VWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGL 691
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 256 bits (653), Expect = 5e-68
Identities = 175/574 (30%), Positives = 283/574 (49%), Gaps = 36/574 (6%)
Query: 33 SLTGHEFF---DFSSGSS--------HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHR 81
S TGH D S SS HAE + + + DVI+ V ++ P HR
Sbjct: 168 SSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHR 227
Query: 82 AVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFE 141
VLS+ S YF AMF +D E+++ +++ GI A+ +Q+ YTG +++ + ++ L
Sbjct: 228 LVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLA 287
Query: 142 TSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQH 201
+ L Q+ + + C FL + L P NCLGI+ FAD L ++ ++ +V ++
Sbjct: 288 AACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRN 347
Query: 202 EEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLH 261
+EFL L +EL + SD++ + EE +F A+M WV + R L LL +RLPLL
Sbjct: 348 QEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLP 407
Query: 262 PNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNE---MMSPRTRPRRSTGYSEVIVVV 318
P + +E L +N EC +L+ EA +YH+L M SPRT+PR+ST + V
Sbjct: 408 PQ-ILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKST--VGTLYAV 464
Query: 319 GGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR--- 375
GG + G E YD T W A + + ++ V + + + V GGR +
Sbjct: 465 GGMDNNKGATT--IEKYDLRTNLWIQ-AGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLN 521
Query: 376 DVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWT 435
V YN + W + ++ R + VL G +Y VGG+DG + L++VE +D S +WT
Sbjct: 522 TVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWT 581
Query: 436 EVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCI 495
VA + A S+ V + GKL+ + GG D ++C ++ YDP TN W + A + + +
Sbjct: 582 FVASMSIARSTVGVAALNGKLYSV-GGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGV 640
Query: 496 TAVSLNNLIYVAGG-----------LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNG 544
+ + +Y GG L + YDP D W V ++ G+ +
Sbjct: 641 GVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGD 700
Query: 545 KIYILGGRRENGEATDTILCYDPATSIITGVAAM 578
++Y +GG + +T+ YDP T+ T +A++
Sbjct: 701 RLYAVGG-YDGQTYLNTMESYDPQTNEWTQMASL 733
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 252 bits (644), Expect = 6e-67
Identities = 164/534 (30%), Positives = 268/534 (50%), Gaps = 27/534 (5%)
Query: 54 QIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGIL 113
+IFNE R DV+I V G EF H+ +L +CSSYFRA+F + + + + I GI
Sbjct: 27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGIS 86
Query: 114 AEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQR 173
+ M+ ++Y YT V IT +NV+ L + F I + C +FL+ +L NC+GI +
Sbjct: 87 PDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICK 146
Query: 174 FADTHSLKTLFTKCKNFALQTFED-VSQHEEFLELDKDELIDYICSDELVIGKEEMVFEA 232
F D + L K F L FE+ V EFLEL EL D I DEL + +E+ VFEA
Sbjct: 147 FTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEA 206
Query: 233 VMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARR-- 290
+++W+ R+ + LL VRL L+H YF+ V+++ +++S EC ++ A +
Sbjct: 207 ILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAM 266
Query: 291 YHILGN-----EMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSL 345
Y + N + +P TRPR ++ +GG GG E YD W ++
Sbjct: 267 YDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWS--GGSPTNAIEAYDARADRWVNV 321
Query: 346 AKLPEFTKSEYAVCALRNDILVSGGRINSRD----VWIYNSQLNIWIRVASLNKGRWRHK 401
E ++ + L+ + + GG +S D V ++ W +VA ++ R
Sbjct: 322 TCEEESPRAYHGAAYLKGYVYIIGG-FDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVS 380
Query: 402 MAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGG 461
+ VL +Y +GG+DG RL++ E Y+ +N+WT +AP+ E S + T+ GK+++ GG
Sbjct: 381 VTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGG 440
Query: 462 GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL-----TKAIYC 516
+ N C + Y+ E+N W + A + + I ++ +Y GG ++
Sbjct: 441 F-NGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEA 499
Query: 517 YDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENG-EATDTILCYDPAT 569
Y PV + W + F+ + N G+ V + ++++GG NG T + CYD T
Sbjct: 500 YSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG--FNGFTTTFNVECYDEKT 551
Score = 74.3 bits (181), Expect = 3e-13
Identities = 51/179 (28%), Positives = 84/179 (46%), Gaps = 9/179 (5%)
Query: 311 YSEVIVVVGGCERVGGFN----LPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDIL 366
Y V V+ +GGF+ L E Y+P T +W +A + E +S+ + L +
Sbjct: 378 YVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHE-QRSDASATTLYGKVY 436
Query: 367 VSGGRINSRDVW---IYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSS 423
+ GG + ++ +YN++ N W +A + R + VY VGG+DG NRL S
Sbjct: 437 ICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRS 496
Query: 424 VECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSW 482
E Y +N W + + S+ + LFV+GG + T + V+ YD +T+ W
Sbjct: 497 AEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF-NGFTTTFNVECYDEKTDEW 554
Score = 47.8 bits (112), Expect = 3e-05
Identities = 46/187 (24%), Positives = 80/187 (42%), Gaps = 27/187 (14%)
Query: 282 YQLLHEARRYHILGNE------MMSPRTRPRRSTGYSEVIVVVGGCERVGGFN----LPY 331
Y L+ A RY N+ M R+ +T Y +V + GGFN L
Sbjct: 397 YVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC-------GGFNGNECLFT 449
Query: 332 TECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG-----RINSRDVWIYNSQLNI 386
E Y+ + +W +A + +S V A + GG R+ S + Y+ N
Sbjct: 450 AEVYNTESNQWTVIAPMRS-RRSGIGVIAYGEHVYAVGGFDGANRLRSAEA--YSPVANT 506
Query: 387 WIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSS 446
W + ++ R + V+ ++VVGG++G +VECYD ++ W + + ++
Sbjct: 507 WRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDM--SIYR 564
Query: 447 PAVTSCV 453
A++ CV
Sbjct: 565 SALSCCV 571
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 244 bits (622), Expect = 2e-64
Identities = 166/557 (29%), Positives = 259/557 (46%), Gaps = 32/557 (5%)
Query: 52 ILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEING 111
+L R DV + V G+E PCHR +L+ S YF AMF D ES VE+
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
Query: 112 ILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGI 171
+ + + +VYTG++ IT NV+ L T++ ++ C ++L++QLD NCLGI
Sbjct: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
Query: 172 QRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFE 231
F + L + K F + FE V++ +EFL+L ++ L+ + D L + E+ E
Sbjct: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
Query: 232 AVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRY 291
A+MRWV R L ELL+ V L + Q + + LIQ S C L +
Sbjct: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDG 240
Query: 292 HILGNEMMSPRTRPRRSTGYSEVIVVVGGC----ERVGGFNLP---YTECYDPVTGEWKS 344
L + EV+VVVGG E G P Y+ W +
Sbjct: 241 APLALQQK-----------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMA 289
Query: 345 LAKLPEFTKSEYAVCALRNDILVSGGRINSR-------DVWIYNSQLNIWIRVASLNKGR 397
L P++ K +++ AL N+I V+GG ++ W + + W VA + K R
Sbjct: 290 LPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPR 349
Query: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLF 457
H A L G++YV+GG + VE YD +++ WT V+P + VS+ + C G+L+
Sbjct: 350 TNHASAALNGEIYVIGGTTLD--VVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLY 407
Query: 458 VIGGGPDDNTCSDKVQSYDPETNSWLLRAA--IPIAKRCITAVSLNNLIYVAGGLTKAIY 515
++G +Q Y+P T++W + A+ +P +L+ +Y+ G TK +Y
Sbjct: 408 LVGSSACKYNAL-ALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDNTKKVY 466
Query: 516 CYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRE--NGEATDTILCYDPATSIIT 573
YDP + W VQ+ S EN + +Y+ GGR + G+ + YD T
Sbjct: 467 VYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWT 526
Query: 574 GVAAMPRPVSYHGCVTI 590
A+PR YHG T+
Sbjct: 527 RHGALPRLWLYHGASTV 543
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 232 bits (591), Expect = 8e-61
Identities = 156/546 (28%), Positives = 263/546 (48%), Gaps = 67/546 (12%)
Query: 59 FRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAME 118
F ++ DV + V K CH+ VL+ YFRAMF ++ E+++ L+EI +A+E
Sbjct: 60 FYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIE 119
Query: 119 CFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTH 178
+++VY+ ++ +T +NVQ L + + Q+ ++ AC ++++ P NCL ++ FA++H
Sbjct: 120 DLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESH 179
Query: 179 SLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVY 238
+ L +A F +V + E+F+ + L + S +L I E+ V+ A ++W+
Sbjct: 180 NRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLL 239
Query: 239 RAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEM 298
L E L VRLPLL ++ + V +Q+++ + +C LL EAR YH+ +
Sbjct: 240 ANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSR 299
Query: 299 MSP------RTRPRRSTGYSEVIVVVGGCERVGGFNLPY--TECYDPVTGEWKSLAKLPE 350
P RT PR+ T + V+ VGG GG P+ ECY
Sbjct: 300 AVPDFEYSIRTTPRKHT--AGVLFCVGG---RGGSGDPFRSIECYS-------------- 340
Query: 351 FTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLL-GKV 409
IN ++ W + ++N R RH + + GKV
Sbjct: 341 ---------------------IN-KNSWFFGPEMN----------SRRRHVGVISVEGKV 368
Query: 410 YVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCS 469
Y VGG+DG L S+E +D +N+W A + A+ S G ++ I GG DDNTC
Sbjct: 369 YAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAI-GGLDDNTCF 427
Query: 470 DKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKAIYCYDPVEDYW 524
+ V+ YD E++ W A + + + +V+L N +Y GG ++ YDP D W
Sbjct: 428 NDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKW 487
Query: 525 MHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSY 584
+ V+ R+ G+S +G +Y++GG +N + ++ YDP ++ VAA+ P
Sbjct: 488 IEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLS-SVERYDPRSNKWDYVAALTTPRGG 546
Query: 585 HGCVTI 590
G T+
Sbjct: 547 VGIATV 552
Score = 81.3 bits (199), Expect = 2e-15
Identities = 55/177 (31%), Positives = 88/177 (49%), Gaps = 7/177 (3%)
Query: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGR--- 371
I +GG + FN E YD + +W ++A + + AL N + GG
Sbjct: 415 IYAIGGLDDNTCFN--DVERYDIESDQWSTVAPM-NTPRGGVGSVALVNHVYAVGGNDGM 471
Query: 372 INSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFS 431
+ V Y+ L+ WI V + + R + ++ L G +YVVGG+D + LSSVE YD S
Sbjct: 472 ASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRS 531
Query: 432 NRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAI 488
N+W VA L + + +GK+F +GG + N + V+++DP N W L ++
Sbjct: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGH-NGNAYLNTVEAFDPVLNRWELVGSV 587
Score = 60.5 bits (145), Expect = 4e-09
Identities = 47/175 (26%), Positives = 82/175 (46%), Gaps = 11/175 (6%)
Query: 286 HEARRYHILGNEM--MSPRTRPRRSTGYSEVI---VVVGGCERVGGFNLPYTECYDPVTG 340
++ RY I ++ ++P PR G ++ VGG + G +L E YDP
Sbjct: 428 NDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGND--GMASLSSVERYDPHLD 485
Query: 341 EWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR---DVWIYNSQLNIWIRVASLNKGR 397
+W + ++ + ++ V L + V GG ++ V Y+ + N W VA+L R
Sbjct: 486 KWIEVKEMGQ-RRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPR 544
Query: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSC 452
+A ++GK++ VGG++G L++VE +D NRW V + + V C
Sbjct: 545 GGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 599
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 224 bits (572), Expect = 1e-58
Identities = 155/550 (28%), Positives = 267/550 (48%), Gaps = 30/550 (5%)
Query: 42 FSSGSSHAENILQIFNEFRDSRLFTDV-IICVEGKE-FPCHRAVLSACSSYFRAMFCNDH 99
F + ++H+ +LQ F++ R L DV ++ +G E FP HRA++++ S YF+AMF
Sbjct: 26 FFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGM 85
Query: 100 RESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFL 159
+E M ++++G+ ++ + ++YT K+ + +N+Q E +S QI + D C FL
Sbjct: 86 KEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 145
Query: 160 EEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSD 219
+ NC+ + R A+T++L + NF L+ F + EFL+L + L + S+
Sbjct: 146 ISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSN 205
Query: 220 ELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSP 279
L E +F+A RW+ R D R +L+ ++R PL+ P + V+ ++
Sbjct: 206 SLKHCTELELFKAACRWL-RLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDN 264
Query: 280 ECYQLLHEARRYHI---LGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYD 336
C LL EA Y + + M S RT R + + +V +GG R YD
Sbjct: 265 TCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTH---LVTLGGVLRQQLVVSKELRMYD 321
Query: 337 PVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN--------SRDVWIYNSQLNIWI 388
EW+SLA + + + ++ + + N + V GG+ N V+ ++ + N W+
Sbjct: 322 ERAQEWRSLAPM-DAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWM 380
Query: 389 RVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPA 448
+VASLN+ R ++ L G +Y VGG L++VECY+ N W+ VA + E A
Sbjct: 381 QVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHA 440
Query: 449 VTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAG 508
T G L I GG +T +++ +DP+T+ W+ +A + + ++ + +YV G
Sbjct: 441 GT-VYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIG 499
Query: 509 G--------LTKAIYC--YDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEA 558
G + C Y P D W + Q + G++V KIY++GG N
Sbjct: 500 GNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRC 559
Query: 559 -TDTILCYDP 567
+ + YDP
Sbjct: 560 MVEIVQKYDP 569
Score = 68.9 bits (167), Expect = 1e-11
Identities = 49/177 (27%), Positives = 80/177 (45%), Gaps = 12/177 (6%)
Query: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS 374
+ VGG G L ECY+P EW +AK+ E +A + +SGG +
Sbjct: 401 LYAVGGRSAAG--ELATVECYNPRMNEWSYVAKMSE-PHYGHAGTVYGGLMYISGGITHD 457
Query: 375 ---RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGY-----DGQNRLSSVEC 426
++ ++ + W++ A + R H M + K+YV+GG + + S E
Sbjct: 458 TFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEY 517
Query: 427 YDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCS-DKVQSYDPETNSW 482
Y ++WT +A + S V K++V+GG +N C + VQ YDPE + W
Sbjct: 518 YSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW 574
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,143,416
Number of Sequences: 37866
Number of extensions: 1023033
Number of successful extensions: 3246
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 1841
Number of HSP's gapped (non-prelim): 382
length of query: 600
length of database: 18,247,518
effective HSP length: 108
effective length of query: 492
effective length of database: 14,157,990
effective search space: 6965731080
effective search space used: 6965731080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.