Search of human proteins with 37595756

Search of human proteins with 37595756

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|37595756 D-lactate dehydrogenase isoform 2 precursor [Homo
sapiens]
         (484 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|37595756 D-lactate dehydrogenase isoform 2 precursor [Homo sa...   979   0.0  
gi|37595754 D-lactate dehydrogenase isoform 1 precursor [Homo sa...   966   0.0  
gi|119964728 D-2-hydroxyglutarate dehydrogenase precursor [Homo ...   162   5e-40
gi|4501993 alkyldihydroxyacetone phosphate synthase precursor [H...    97   3e-20
gi|13375618 24-dehydrocholesterol reductase precursor [Homo sapi...    36   0.089
gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo ...    31   2.9  
gi|4826784 potassium voltage-gated channel, Shab-related subfami...    30   6.4  

>gi|37595756 D-lactate dehydrogenase isoform 2 precursor [Homo
           sapiens]
          Length = 484

 Score =  979 bits (2531), Expect = 0.0
 Identities = 484/484 (100%), Positives = 484/484 (100%)

Query: 1   MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV 60
           MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV
Sbjct: 1   MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV 60

Query: 61  HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD 120
           HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD
Sbjct: 61  HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD 120

Query: 121 RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY 180
           RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY
Sbjct: 121 RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY 180

Query: 181 GTMRDNVLNLEVVLPDGRLLHTAGRGRHFRKSAAGYNLTGLFVGSEGTLGLITATTLRLH 240
           GTMRDNVLNLEVVLPDGRLLHTAGRGRHFRKSAAGYNLTGLFVGSEGTLGLITATTLRLH
Sbjct: 181 GTMRDNVLNLEVVLPDGRLLHTAGRGRHFRKSAAGYNLTGLFVGSEGTLGLITATTLRLH 240

Query: 241 PAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIEFLDEVMMDACNRYSKLNCLVAPT 300
           PAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIEFLDEVMMDACNRYSKLNCLVAPT
Sbjct: 241 PAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIEFLDEVMMDACNRYSKLNCLVAPT 300

Query: 301 LFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEAEERSRLWTARHNAWYAALATRPG 360
           LFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEAEERSRLWTARHNAWYAALATRPG
Sbjct: 301 LFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEAEERSRLWTARHNAWYAALATRPG 360

Query: 361 CKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVGHVGDGNFHCILLVNPDDAEELGR 420
           CKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVGHVGDGNFHCILLVNPDDAEELGR
Sbjct: 361 CKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVGHVGDGNFHCILLVNPDDAEELGR 420

Query: 421 VKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNP 480
           VKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNP
Sbjct: 421 VKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNP 480

Query: 481 GKVL 484
           GKVL
Sbjct: 481 GKVL 484


>gi|37595754 D-lactate dehydrogenase isoform 1 precursor [Homo
           sapiens]
          Length = 507

 Score =  966 bits (2497), Expect = 0.0
 Identities = 484/507 (95%), Positives = 484/507 (95%), Gaps = 23/507 (4%)

Query: 1   MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV 60
           MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV
Sbjct: 1   MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVGGSHVSTAAVVREQHGRDESV 60

Query: 61  HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD 120
           HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD
Sbjct: 61  HRCEPPDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMD 120

Query: 121 RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY 180
           RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY
Sbjct: 121 RILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRY 180

Query: 181 GTMRDNVLNLEVVLPDGRLLHTAGRGRHFR-----------------------KSAAGYN 217
           GTMRDNVLNLEVVLPDGRLLHTAGRGRHFR                       KSAAGYN
Sbjct: 181 GTMRDNVLNLEVVLPDGRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKSAAGYN 240

Query: 218 LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE 277
           LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE
Sbjct: 241 LTGLFVGSEGTLGLITATTLRLHPAPEATVAATCAFPSVQAAVDSTVHILQAAVPVARIE 300

Query: 278 FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA 337
           FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA
Sbjct: 301 FLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEA 360

Query: 338 EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG 397
           EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG
Sbjct: 361 EERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVG 420

Query: 398 HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV 457
           HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV
Sbjct: 421 HVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEV 480

Query: 458 GAVGVETMRQLKAVLDPQGLMNPGKVL 484
           GAVGVETMRQLKAVLDPQGLMNPGKVL
Sbjct: 481 GAVGVETMRQLKAVLDPQGLMNPGKVL 507


>gi|119964728 D-2-hydroxyglutarate dehydrogenase precursor [Homo
           sapiens]
          Length = 521

 Score =  162 bits (411), Expect = 5e-40
 Identities = 126/422 (29%), Positives = 196/422 (46%), Gaps = 19/422 (4%)

Query: 72  PQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTHMDRILELNQEDFS 131
           P+  E+VS +   C+ + + + P G  TG+ GG   V   + ++   M+R+L  +     
Sbjct: 106 PRTSEEVSHILRHCHERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGI 165

Query: 132 VVVEPGVTRKALNAHLRDSGLWFPVDPGADAS--LCGMAATGASGTNAVRYGTMRDNVLN 189
           +V + G   + L+ ++ +     P+D GA  S  + G  AT A G   +RYG++   VL 
Sbjct: 166 LVCQAGCVLEELSRYVEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLHGTVLG 225

Query: 190 LEVVLPDGRLLHTAGRGRHFRKSAAGYNLTGLFVGSEGTLGLITATTLRLHPAPEATVAA 249
           LEVVL DG +L         RK   GY+L  LF+GSEGTLG+IT  ++   P P A   A
Sbjct: 226 LEVVLADGTVLDCL---TSLRKDNTGYDLKQLFIGSEGTLGIITTVSILCPPKPRAVNVA 282

Query: 250 TCAFPSVQAAVD--STVHILQAAVPVARIEFLDEVMMDACNRYSKLNCLVAPTLF---LE 304
               P     +   ST   +   + ++  EF+D V M    R+  L   V  + F   +E
Sbjct: 283 FLGCPGFAEVLQTFSTCKGMLGEI-LSAFEFMDAVCMQLVGRHLHLASPVQESPFYVLIE 341

Query: 305 FHGSQQALE-EQLQRTEEIVQQNG-ASDFSWAKEAEERSRLWTARHNAWYAALATRPGCK 362
             GS    + E+L    E    +G  +D + A +  +   LW  R     A   +R G  
Sbjct: 342 TSGSNAGHDAEKLGHFLEHALGSGLVTDGTMATDQRKVKMLWALRERITEAL--SRDGYV 399

Query: 363 GYSTDVCVPISRLPEIVVQTKEDLNASGLTGSIVGHVGDGNFHCILLVNPDDAEELGRVK 422
            Y  D+ +P+ RL +IV   +  L          GH+GDGN H  +     +A     + 
Sbjct: 400 -YKYDLSLPVERLYDIVTDLRARLGPHAKHVVGYGHLGDGNLHLNVTA---EAFSPSLLA 455

Query: 423 AFAEQLGRRALALHGTCTGEHGIGMGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNPGK 482
           A    +        G+ + EHG+G  KR +L        ++ M+QLKA+LDP+G++NP K
Sbjct: 456 ALEPHVYEWTAGQQGSVSAEHGVGFRKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYK 515

Query: 483 VL 484
            L
Sbjct: 516 TL 517


>gi|4501993 alkyldihydroxyacetone phosphate synthase precursor [Homo
           sapiens]
          Length = 658

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 103/461 (22%), Positives = 193/461 (41%), Gaps = 50/461 (10%)

Query: 66  PDAVVWPQNVEQVSRLAALCYRQGVPIIPFGTGTGLEGGVCA----VQGGVCVNLTHMDR 121
           PD V+WP   + V ++  L  +  + IIP G GT +  G+       +  + ++ + M+R
Sbjct: 206 PDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNR 265

Query: 122 ILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGA--DASLCGMAATGASGTNAVR 179
           IL +++ + +  VE G+T + L   L++SG     +P +   +++ G  +T ASG     
Sbjct: 266 ILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNI 325

Query: 180 YGTMRDNVLNLEVVLPDGRLLHTAGRGRHFRKSAAGYNLTGLFVGSEGTLGLITATTLRL 239
           YG + D V+++++V P G ++  + +G    + + G ++    +GSEGTLG+IT  T+++
Sbjct: 326 YGNIEDLVVHIKMVTPRG-IIEKSCQGP---RMSTGPDIHHFIMGSEGTLGVITEATIKI 381

Query: 240 HPAPEATVAATCAFPSVQAAVDSTV-----------------------HILQAAVPVARI 276
            P PE     + AFP+ +  V                           H L+  V     
Sbjct: 382 RPVPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNKQFQFGHALKPQVSSIFT 441

Query: 277 EFLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKE 336
            FLD +      ++   +        L F G ++ + +  ++  +I  + G    +  ++
Sbjct: 442 SFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGG--LAAGED 499

Query: 337 AEERSRLWTARHNAWYAALATRPGCKGYSTDVCVPISRLPEIVVQTKEDLNASGLTGSI- 395
             +R  L T    A+   LA      G S +   P  R+ ++    KE +        + 
Sbjct: 500 NGQRGYLLTYVI-AYIRDLALEYYVLGESFETSAPWDRVVDLCRNVKERITRECKEKGVQ 558

Query: 396 --------VGHVGDGNFHCILLVNPDDAEELGRVKAFAEQLGRRA----LALHGTCTGEH 443
                   V    D    CI      +   +       EQ    A    LA  G+ +  H
Sbjct: 559 FAPFSTCRVTQTYDAGA-CIYFYFAFNYRGISDPLTVFEQTEAAAREEILANGGSLSHHH 617

Query: 444 GIGMGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNPGKVL 484
           G+G  ++Q L+E +  VG   ++ +K  +DP  +     +L
Sbjct: 618 GVGKLRKQWLKESISDVGFGMLKSVKEYVDPNNIFGNRNLL 658


>gi|13375618 24-dehydrocholesterol reductase precursor [Homo
           sapiens]
          Length = 516

 Score = 35.8 bits (81), Expect = 0.089
 Identities = 39/132 (29%), Positives = 57/132 (43%), Gaps = 12/132 (9%)

Query: 112 VCVNLTHMDRILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVDPGADASLCGMAATG 171
           + +NL  MD ILE++ +   V VEP VT   + A L   G   PV P  D    G    G
Sbjct: 114 IMINL--MD-ILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMG 170

Query: 172 AS-GTNAVRYGTMRDNVLNLEVVLPDGRLLHTAGRGRHFRKSAAGYNLTGLFVGSEGTLG 230
               +++ +YG  +      E+VL DG  +            +   +L      S GTLG
Sbjct: 171 TGIESSSHKYGLFQHICTAYELVLADGSFVRCT--------PSENSDLFYAVPWSCGTLG 222

Query: 231 LITATTLRLHPA 242
            + A  +R+ PA
Sbjct: 223 FLVAAEIRIIPA 234


>gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo
           sapiens]
          Length = 605

 Score = 30.8 bits (68), Expect = 2.9
 Identities = 19/92 (20%), Positives = 40/92 (43%)

Query: 268 QAAVPVARIEFLDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNG 327
           ++ +P   +   ++ ++ +CNR +K +       F   HG   AL+      +  +    
Sbjct: 326 ESTLPTKFMVGTEQGIVISCNRKAKTSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGD 385

Query: 328 ASDFSWAKEAEERSRLWTARHNAWYAALATRP 359
            +   W++++ E S +WT  H A+    A  P
Sbjct: 386 WTARIWSEDSRESSIMWTKYHMAYLTDAAWSP 417


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score = 29.6 bits (65), Expect = 6.4
 Identities = 14/66 (21%), Positives = 32/66 (48%), Gaps = 13/66 (19%)

Query: 279 LDEVMMDACNRYSKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGASDFSWAKEAE 338
           +DE+ +++C +               +H  ++ + E+L+R  E +++    +F     AE
Sbjct: 124 IDEIYLESCCQ-------------ARYHQKKEQMNEELKREAETLREREGEEFDNTCCAE 170

Query: 339 ERSRLW 344
           +R +LW
Sbjct: 171 KRKKLW 176


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,685,752
Number of Sequences: 37866
Number of extensions: 823281
Number of successful extensions: 2021
Number of sequences better than 10.0: 7
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2008
Number of HSP's gapped (non-prelim): 8
length of query: 484
length of database: 18,247,518
effective HSP length: 106
effective length of query: 378
effective length of database: 14,233,722
effective search space: 5380346916
effective search space used: 5380346916
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.