Search of human proteins with 27735155

Search of human proteins with 27735155

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27735155 poly(A)-specific ribonuclease (PARN)-like domain
containing 1 [Homo sapiens]
         (520 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27735155 poly(A)-specific ribonuclease (PARN)-like domain con...  1070   0.0  
gi|4505611 poly(A)-specific ribonuclease (deadenylation nuclease...   157   2e-38
gi|197333695 poly(A)-specific ribonuclease (deadenylation nuclea...   140   2e-33
gi|156564398 target of EGR1, member 1 (nuclear) [Homo sapiens]         46   7e-05
gi|109389364 arsenic (+3 oxidation state) methyltransferase [Hom...    30   4.1  
gi|229892308 shugoshin-like 2 isoform 2 [Homo sapiens]                 30   7.0  
gi|229892306 shugoshin-like 2 isoform 1 [Homo sapiens]                 30   7.0  
gi|229892197 shugoshin-like 2 isoform 3 [Homo sapiens]                 30   7.0  
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]           29   9.1  
gi|238550149 tRNA phosphotransferase 1 isoform 3 [Homo sapiens]        29   9.1  

>gi|27735155 poly(A)-specific ribonuclease (PARN)-like domain
           containing 1 [Homo sapiens]
          Length = 520

 Score = 1070 bits (2767), Expect = 0.0
 Identities = 520/520 (100%), Positives = 520/520 (100%)

Query: 1   MFCTRGLLFFAFLAGLDIEFTGLRSNLSGPQQISLFDLPSEWYLKTRQSVQQFTVCQIGL 60
           MFCTRGLLFFAFLAGLDIEFTGLRSNLSGPQQISLFDLPSEWYLKTRQSVQQFTVCQIGL
Sbjct: 1   MFCTRGLLFFAFLAGLDIEFTGLRSNLSGPQQISLFDLPSEWYLKTRQSVQQFTVCQIGL 60

Query: 61  SVFSAIEGEANKYIAHSCNFYLFPTTFGILDSEFSFQASSVQFLNQYGFNYNKFLKNGIP 120
           SVFSAIEGEANKYIAHSCNFYLFPTTFGILDSEFSFQASSVQFLNQYGFNYNKFLKNGIP
Sbjct: 61  SVFSAIEGEANKYIAHSCNFYLFPTTFGILDSEFSFQASSVQFLNQYGFNYNKFLKNGIP 120

Query: 121 YMNEEQEKKIRHDILTGNWRVRSSPDKDQIKVVIDEVTRWLELAKEGDWMTLPGITGFQA 180
           YMNEEQEKKIRHDILTGNWRVRSSPDKDQIKVVIDEVTRWLELAKEGDWMTLPGITGFQA
Sbjct: 121 YMNEEQEKKIRHDILTGNWRVRSSPDKDQIKVVIDEVTRWLELAKEGDWMTLPGITGFQA 180

Query: 181 FEVQLVLRQALPNIWTVLKDEGVVVKKVSKQHRWYLQNTSCDRESCWKENILLSARGFSV 240
           FEVQLVLRQALPNIWTVLKDEGVVVKKVSKQHRWYLQNTSCDRESCWKENILLSARGFSV
Sbjct: 181 FEVQLVLRQALPNIWTVLKDEGVVVKKVSKQHRWYLQNTSCDRESCWKENILLSARGFSV 240

Query: 241 FFQMLVKAQKPLVGHNMMMDLLHLHEKFFRPLPESYDQFKQNIHSLFPVLIDTKSVTKDI 300
           FFQMLVKAQKPLVGHNMMMDLLHLHEKFFRPLPESYDQFKQNIHSLFPVLIDTKSVTKDI
Sbjct: 241 FFQMLVKAQKPLVGHNMMMDLLHLHEKFFRPLPESYDQFKQNIHSLFPVLIDTKSVTKDI 300

Query: 301 WKEMNFPRVSNLSEVYEVLNSDLNPTKNSGPEIVHASRCEKYVETKCPHEAAYDAFLCGS 360
           WKEMNFPRVSNLSEVYEVLNSDLNPTKNSGPEIVHASRCEKYVETKCPHEAAYDAFLCGS
Sbjct: 301 WKEMNFPRVSNLSEVYEVLNSDLNPTKNSGPEIVHASRCEKYVETKCPHEAAYDAFLCGS 360

Query: 361 VLLKVAHLLLQKIYHIDPVPESSFPQYLDVLAPYVNQVNLIRAGVPKINFSGPDYPSIRP 420
           VLLKVAHLLLQKIYHIDPVPESSFPQYLDVLAPYVNQVNLIRAGVPKINFSGPDYPSIRP
Sbjct: 361 VLLKVAHLLLQKIYHIDPVPESSFPQYLDVLAPYVNQVNLIRAGVPKINFSGPDYPSIRP 420

Query: 421 PILILSVKRWPGVSEQQVYHKFQNLCKFDVRRLTRSQFLLLTNKFKDARNILKEYRDHPT 480
           PILILSVKRWPGVSEQQVYHKFQNLCKFDVRRLTRSQFLLLTNKFKDARNILKEYRDHPT
Sbjct: 421 PILILSVKRWPGVSEQQVYHKFQNLCKFDVRRLTRSQFLLLTNKFKDARNILKEYRDHPT 480

Query: 481 LCISLYRYWRHSPNVNCLLQVCGIVTAWALLAFILGRSGT 520
           LCISLYRYWRHSPNVNCLLQVCGIVTAWALLAFILGRSGT
Sbjct: 481 LCISLYRYWRHSPNVNCLLQVCGIVTAWALLAFILGRSGT 520


>gi|4505611 poly(A)-specific ribonuclease (deadenylation nuclease)
           isoform 1 [Homo sapiens]
          Length = 639

 Score =  157 bits (397), Expect = 2e-38
 Identities = 131/466 (28%), Positives = 214/466 (45%), Gaps = 47/466 (10%)

Query: 9   FFAFLAGLDIEFTGLRSNLSGPQQISLFDLPSEWYLKTRQSVQQFTVCQIGLSVFSAIEG 68
           FFA    +D EF+G+    S     + FD P E Y K ++    F + Q GL  F   + 
Sbjct: 24  FFA----IDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFK-YDY 78

Query: 69  EANKYIAHSCNFYLFPTTFGIL--DSEFSFQASSVQFLNQYGFNYNKFLKNGIPYMNEEQ 126
             +KYI  S NFY+FP  F     D +F  Q+SS+ FL   GF++NK  +NGIPY+N+E+
Sbjct: 79  TDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEE 138

Query: 127 EKKIRHDILTGNWRVRS-------SPDKDQIKVVI--------DEVTRWLE---LAKEGD 168
           E+++R        +          SP+  +  V I        D+V   +E    ++E  
Sbjct: 139 ERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENK 198

Query: 169 WMTLPGITGFQAFEVQLVLRQALPN------IWTVLKDEGVVVKKVSKQHRWYLQNTSCD 222
            + L   TGFQ   +   L    P       + T  K+  +V+ KV ++ R   +     
Sbjct: 199 NLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHA 258

Query: 223 RESCWKENILLSARGFSVFFQMLVKAQKPLVGHNMMMDLLHLHEKFFRPLPESYDQFKQN 282
           +E    +  L  A GFS     +  + K ++GHNM++D++H   +F+ PLP    +FK+ 
Sbjct: 259 KE----QEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEM 314

Query: 283 IHSLFPVLIDTKSVTKDIWKEMNFPRVSNLSEVYEVLNSDLNPTKNSGPEIVHASRCEKY 342
              +FP L+DTK +         F  + N + + E L   L  T  + P++  A     Y
Sbjct: 315 TTCVFPRLLDTKLMA----STQPFKDIINNTSLAE-LEKRLKETPFNPPKVESAEGFPSY 369

Query: 343 -VETKCPHEAAYDAFLCGSVLLKVAHLLLQKIYHIDPVPESSFPQYLDVLAPYVNQVNLI 401
              ++  HEA YDA++ G   + +A+ L      + P P+        ++ P+ N++ L+
Sbjct: 370 DTASEQLHEAGYDAYITGLCFISMANYLGS---FLSP-PKIHVSARSKLIEPFFNKLFLM 425

Query: 402 RA-GVPKINFSGPDYPSIRPPIL-ILSVKRWPGVSEQQVYHKFQNL 445
           R   +P +N  GPD    R  +L +   K W      Q++  F N+
Sbjct: 426 RVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNI 471


>gi|197333695 poly(A)-specific ribonuclease (deadenylation nuclease)
           isoform 2 [Homo sapiens]
          Length = 578

 Score =  140 bits (354), Expect = 2e-33
 Identities = 117/422 (27%), Positives = 194/422 (45%), Gaps = 43/422 (10%)

Query: 53  FTVCQIGLSVFSAIEGEANKYIAHSCNFYLFPTTFGIL--DSEFSFQASSVQFLNQYGFN 110
           F + Q GL  F   +   +KYI  S NFY+FP  F     D +F  Q+SS+ FL   GF+
Sbjct: 3   FLLFQFGLCTFK-YDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFD 61

Query: 111 YNKFLKNGIPYMNEEQEKKIRHDILTGNWRVRS-------SPDKDQIKVVI--------D 155
           +NK  +NGIPY+N+E+E+++R        +          SP+  +  V I        D
Sbjct: 62  FNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFID 121

Query: 156 EVTRWLE---LAKEGDWMTLPGITGFQAFEVQLVLRQALPN------IWTVLKDEGVVVK 206
           +V   +E    ++E   + L   TGFQ   +   L    P       + T  K+  +V+ 
Sbjct: 122 QVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVIS 181

Query: 207 KVSKQHRWYLQNTSCDRESCWKENILLSARGFSVFFQMLVKAQKPLVGHNMMMDLLHLHE 266
           KV ++ R   +     +E    +  L  A GFS     +  + K ++GHNM++D++H   
Sbjct: 182 KVDEEERKRREQQKHAKE----QEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVH 237

Query: 267 KFFRPLPESYDQFKQNIHSLFPVLIDTKSVTKDIWKEMNFPRVSNLSEVYEVLNSDLNPT 326
           +F+ PLP    +FK+    +FP L+DTK +         F  + N + + E L   L  T
Sbjct: 238 QFYCPLPADLSEFKEMTTCVFPRLLDTKLMA----STQPFKDIINNTSLAE-LEKRLKET 292

Query: 327 KNSGPEIVHASRCEKY-VETKCPHEAAYDAFLCGSVLLKVAHLLLQKIYHIDPVPESSFP 385
             + P++  A     Y   ++  HEA YDA++ G   + +A+ L      + P P+    
Sbjct: 293 PFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGS---FLSP-PKIHVS 348

Query: 386 QYLDVLAPYVNQVNLIRA-GVPKINFSGPDYPSIRPPIL-ILSVKRWPGVSEQQVYHKFQ 443
               ++ P+ N++ L+R   +P +N  GPD    R  +L +   K W      Q++  F 
Sbjct: 349 ARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFG 408

Query: 444 NL 445
           N+
Sbjct: 409 NI 410


>gi|156564398 target of EGR1, member 1 (nuclear) [Homo sapiens]
          Length = 510

 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 22/54 (40%), Positives = 36/54 (66%), Gaps = 1/54 (1%)

Query: 242 FQMLVKAQKPLVGHNMMMDLLHLHEKFFRPLPESYDQFKQNIHSLFPV-LIDTK 294
           F  L++A++PLV HN ++DL+ L++ F+  LPES   F  ++  +FP  + DTK
Sbjct: 177 FLELIRARRPLVLHNGLIDLVFLYQNFYAHLPESLGTFTADLCEMFPAGIYDTK 230



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 34/128 (26%), Positives = 56/128 (43%), Gaps = 18/128 (14%)

Query: 11  AFLAGLDIEFTGLRSNLSGPQQISLFDLPSEWYLKTRQSVQQFTVCQIGLSVFSAIEGEA 70
           A    +D E +GL     G ++  L     E Y     + +  ++  +GL+ F     + 
Sbjct: 58  ANFVAVDTELSGL-----GDRKSLLNQCIEERYKAVCHAARTRSILSLGLACFKRQPDKG 112

Query: 71  -NKYIAHSCNFYLFPTTFGILDSEFSFQASSVQFLNQYGFNYNKFLKNGIPYM------N 123
            + Y+A   N  L      +   E+  +  SVQFL Q+GFN+N+    GIPY       +
Sbjct: 113 EHSYLAQVFNLTL------LCMEEYVIEPKSVQFLIQHGFNFNQQYAQGIPYHKGNDKGD 166

Query: 124 EEQEKKIR 131
           E Q + +R
Sbjct: 167 ESQSQSVR 174


>gi|109389364 arsenic (+3 oxidation state) methyltransferase [Homo
           sapiens]
          Length = 375

 Score = 30.4 bits (67), Expect = 4.1
 Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 11/58 (18%)

Query: 93  EFSFQASSVQFLNQYGFNYNKFLKNGIPYMNEEQEKKIRHDILTGNWRVRSSPDKDQI 150
           ++ FQAS+V F++ Y           I  + E   K   HDI+  N  +   PDK Q+
Sbjct: 121 KYGFQASNVTFIHGY-----------IEKLGEAGIKNESHDIVVSNCVINLVPDKQQV 167


>gi|229892308 shugoshin-like 2 isoform 2 [Homo sapiens]
          Length = 1260

 Score = 29.6 bits (65), Expect = 7.0
 Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 30/143 (20%)

Query: 86  TFGILDSEFSFQASSVQFLNQYGFNYNKFLK---------NGIPYMNEEQEKKIRHDILT 136
           T  ILD       + +Q   Q   N NK  K         +G+ +M E+ +K + H +  
Sbjct: 586 THNILD--LKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKK 643

Query: 137 GNWRVRSSPDKDQIKVVIDEVTRWLEL--------AKEGDWMTLPGITGFQAFEVQLVLR 188
           GN+  ++  DK+ I   I EV++ L++          + D+ T          +  L L+
Sbjct: 644 GNFFFKTQEDKEPISENI-EVSKELQIPALSTRDNENQCDYRT----------QNVLGLQ 692

Query: 189 QALPNIWTVLKDEGVVVKKVSKQ 211
           + + N++ V ++E  V KK+ ++
Sbjct: 693 KQITNMYPVQQNESKVNKKLRQK 715


>gi|229892306 shugoshin-like 2 isoform 1 [Homo sapiens]
          Length = 1265

 Score = 29.6 bits (65), Expect = 7.0
 Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 30/143 (20%)

Query: 86  TFGILDSEFSFQASSVQFLNQYGFNYNKFLK---------NGIPYMNEEQEKKIRHDILT 136
           T  ILD       + +Q   Q   N NK  K         +G+ +M E+ +K + H +  
Sbjct: 586 THNILD--LKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKK 643

Query: 137 GNWRVRSSPDKDQIKVVIDEVTRWLEL--------AKEGDWMTLPGITGFQAFEVQLVLR 188
           GN+  ++  DK+ I   I EV++ L++          + D+ T          +  L L+
Sbjct: 644 GNFFFKTQEDKEPISENI-EVSKELQIPALSTRDNENQCDYRT----------QNVLGLQ 692

Query: 189 QALPNIWTVLKDEGVVVKKVSKQ 211
           + + N++ V ++E  V KK+ ++
Sbjct: 693 KQITNMYPVQQNESKVNKKLRQK 715


>gi|229892197 shugoshin-like 2 isoform 3 [Homo sapiens]
          Length = 1261

 Score = 29.6 bits (65), Expect = 7.0
 Identities = 34/143 (23%), Positives = 64/143 (44%), Gaps = 30/143 (20%)

Query: 86  TFGILDSEFSFQASSVQFLNQYGFNYNKFLK---------NGIPYMNEEQEKKIRHDILT 136
           T  ILD       + +Q   Q   N NK  K         +G+ +M E+ +K + H +  
Sbjct: 586 THNILD--LKKYVTDIQPSEQNESNINKLRKKVNRKTEIISGMNHMYEDNDKDVVHGLKK 643

Query: 137 GNWRVRSSPDKDQIKVVIDEVTRWLEL--------AKEGDWMTLPGITGFQAFEVQLVLR 188
           GN+  ++  DK+ I   I EV++ L++          + D+ T          +  L L+
Sbjct: 644 GNFFFKTQEDKEPISENI-EVSKELQIPALSTRDNENQCDYRT----------QNVLGLQ 692

Query: 189 QALPNIWTVLKDEGVVVKKVSKQ 211
           + + N++ V ++E  V KK+ ++
Sbjct: 693 KQITNMYPVQQNESKVNKKLRQK 715


>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
          Length = 1434

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 8/66 (12%)

Query: 284 HSLFPVLIDTKSVTKDIWKEMNFPRVSN--LSEVYEVLNS-DLNPTKNSGPEIVHASRCE 340
           H   P+ ++   V  D+W + N P V N   SE  +   S   +PTKN  P     S+C 
Sbjct: 249 HKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSP-----SKCP 303

Query: 341 KYVETK 346
           ++++ K
Sbjct: 304 RFLKVK 309


>gi|238550149 tRNA phosphotransferase 1 isoform 3 [Homo sapiens]
          Length = 255

 Score = 29.3 bits (64), Expect = 9.1
 Identities = 13/40 (32%), Positives = 21/40 (52%), Gaps = 2/40 (5%)

Query: 396 NQVNLIRAGVPKINFSGPDYPSIRPPILILSV--KRWPGV 433
           NQ + ++ GVPK+     + P   PP+L+     K WP +
Sbjct: 103 NQGHSLQVGVPKLELMPLETPQALPPMLVHGTFWKHWPSI 142


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,897,876
Number of Sequences: 37866
Number of extensions: 860424
Number of successful extensions: 1931
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1918
Number of HSP's gapped (non-prelim): 12
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.