Search of human proteins with 239747686

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo
sapiens]
         (702 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]    1416   0.0  
gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]    1416   0.0  
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai...  1416   0.0  
gi|40018614 DRE1 protein [Homo sapiens]                               261   1e-69
gi|166235129 kelch-like 3 [Homo sapiens]                              223   5e-58
gi|55925608 kelch-like 21 [Homo sapiens]                              223   5e-58
gi|38194229 kelch-like 17 [Homo sapiens]                              222   1e-57
gi|11056006 kelch-like 12 [Homo sapiens]                              219   5e-57
gi|55925604 kelch-like 18 [Homo sapiens]                              217   3e-56
gi|40807500 kelch-like 20 [Homo sapiens]                              216   4e-56
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]            209   7e-54
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]            209   7e-54
gi|109150407 kelch-like 6 [Homo sapiens]                              201   2e-51
gi|194097389 kelch-like 38 [Homo sapiens]                             196   8e-50
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]              189   8e-48
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]                    186   5e-47
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]                     186   8e-47
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]                     186   8e-47
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo...   185   1e-46
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]               184   2e-46
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]            181   2e-45
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]                    181   2e-45
gi|14780904 kelch-like 1 protein [Homo sapiens]                       176   9e-44
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]                     171   2e-42
gi|148664209 kelch-like 10 [Homo sapiens]                             167   3e-41
gi|128485503 kelch-like 30 [Homo sapiens]                             164   2e-40
gi|40255071 kelch-like 23 [Homo sapiens]                              162   1e-39
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]                     161   2e-39
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]                     161   2e-39
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo...   159   6e-39

>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
          Length = 875

 Score = 1416 bits (3666), Expect = 0.0
 Identities = 702/702 (100%), Positives = 702/702 (100%)

Query: 1   MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60
           MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP
Sbjct: 1   MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60

Query: 61  SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120
           SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI
Sbjct: 61  SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120

Query: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180
           NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA
Sbjct: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180

Query: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240
           PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG
Sbjct: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240

Query: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300
           VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG
Sbjct: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300

Query: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360
           VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR
Sbjct: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360

Query: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420
           SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC
Sbjct: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420

Query: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480
           KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF
Sbjct: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480

Query: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540
           IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE
Sbjct: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540

Query: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600
           ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR
Sbjct: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600

Query: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
           SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL
Sbjct: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660

Query: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
           DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER
Sbjct: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702



 Score = 33.9 bits (76), Expect = 0.53
 Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 2/59 (3%)

Query: 624 YDREFFSVVSAGDNIYLSGGMES--GVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
           + R+F S V     IY +GG+ S  G  L ++  Y    + W L+  M  P  RH  +V
Sbjct: 809 HSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVV 867



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 28/106 (26%), Positives = 44/106 (41%), Gaps = 8/106 (7%)

Query: 586 IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME 645
           I + GG    G   R+   +  + PQ N W  + S P  D ++   V+    +++ GG  
Sbjct: 732 IYVFGGVNEAG---RAAGVLQSYVPQTNTWSFIES-PMIDNKYAPAVTLNGFVFILGGAY 787

Query: 646 SGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGL 691
           +  T      Y     N      M   R   +++V DGKIY  GG+
Sbjct: 788 ARATTI----YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGI 829



 Score = 29.6 bits (65), Expect = 10.0
 Identities = 19/79 (24%), Positives = 36/79 (45%), Gaps = 2/79 (2%)

Query: 613 NKWYPLASLPFYDREFFSVVSAGDNIYLSGGM-ESGVTLADVWCYMSLLDNWNLVSRMTV 671
           N+W  +A LP       + V  G  IY+ GG+ E+G     +  Y+   + W+ +    +
Sbjct: 708 NQWEAVAPLPKAVHSAAATV-CGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMI 766

Query: 672 PRCRHNSLVYDGKIYTLGG 690
                 ++  +G ++ LGG
Sbjct: 767 DNKYAPAVTLNGFVFILGG 785


>gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
          Length = 702

 Score = 1416 bits (3666), Expect = 0.0
 Identities = 702/702 (100%), Positives = 702/702 (100%)

Query: 1   MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60
           MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP
Sbjct: 1   MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60

Query: 61  SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120
           SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI
Sbjct: 61  SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120

Query: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180
           NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA
Sbjct: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180

Query: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240
           PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG
Sbjct: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240

Query: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300
           VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG
Sbjct: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300

Query: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360
           VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR
Sbjct: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360

Query: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420
           SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC
Sbjct: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420

Query: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480
           KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF
Sbjct: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480

Query: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540
           IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE
Sbjct: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540

Query: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600
           ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR
Sbjct: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600

Query: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
           SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL
Sbjct: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660

Query: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
           DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER
Sbjct: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702


>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
           containing 9 [Homo sapiens]
          Length = 875

 Score = 1416 bits (3666), Expect = 0.0
 Identities = 702/702 (100%), Positives = 702/702 (100%)

Query: 1   MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60
           MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP
Sbjct: 1   MSRHHSRFERDYRVGWDRREWSVNGTHGTTSICSVTSGAGGGTASSLSVRPGLLPLPVVP 60

Query: 61  SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120
           SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI
Sbjct: 61  SRLPTPATAPAPCTTGSSEAITSLVASSASAVTTKAPGISKGDSQSQGLATSIRWGQTPI 120

Query: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180
           NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA
Sbjct: 121 NQSTPWDTDEPPSKQMRESDNPGTGPWVTTVAAGNQPTLIAHSYGVAQPPTFSPAVNVQA 180

Query: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240
           PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG
Sbjct: 181 PVIGVTPSLPPHVGPQLPLMPGHYSLPQPPSQPLSSVVVNMPAQALYASPQPLAVSTLPG 240

Query: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300
           VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG
Sbjct: 241 VGQVARPGPTAVGNGHMAGPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIG 300

Query: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360
           VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR
Sbjct: 301 VGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR 360

Query: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420
           SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC
Sbjct: 361 SVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFC 420

Query: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480
           KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF
Sbjct: 421 KVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDF 480

Query: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540
           IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE
Sbjct: 481 IAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNE 540

Query: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600
           ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR
Sbjct: 541 ELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQR 600

Query: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
           SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL
Sbjct: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660

Query: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
           DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER
Sbjct: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702



 Score = 33.9 bits (76), Expect = 0.53
 Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 2/59 (3%)

Query: 624 YDREFFSVVSAGDNIYLSGGMES--GVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
           + R+F S V     IY +GG+ S  G  L ++  Y    + W L+  M  P  RH  +V
Sbjct: 809 HSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVV 867



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 28/106 (26%), Positives = 44/106 (41%), Gaps = 8/106 (7%)

Query: 586 IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME 645
           I + GG    G   R+   +  + PQ N W  + S P  D ++   V+    +++ GG  
Sbjct: 732 IYVFGGVNEAG---RAAGVLQSYVPQTNTWSFIES-PMIDNKYAPAVTLNGFVFILGGAY 787

Query: 646 SGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGL 691
           +  T      Y     N      M   R   +++V DGKIY  GG+
Sbjct: 788 ARATTI----YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGI 829



 Score = 29.6 bits (65), Expect = 10.0
 Identities = 19/79 (24%), Positives = 36/79 (45%), Gaps = 2/79 (2%)

Query: 613 NKWYPLASLPFYDREFFSVVSAGDNIYLSGGM-ESGVTLADVWCYMSLLDNWNLVSRMTV 671
           N+W  +A LP       + V  G  IY+ GG+ E+G     +  Y+   + W+ +    +
Sbjct: 708 NQWEAVAPLPKAVHSAAATV-CGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMI 766

Query: 672 PRCRHNSLVYDGKIYTLGG 690
                 ++  +G ++ LGG
Sbjct: 767 DNKYAPAVTLNGFVFILGG 785


>gi|40018614 DRE1 protein [Homo sapiens]
          Length = 600

 Score =  261 bits (668), Expect = 1e-69
 Identities = 149/402 (37%), Positives = 228/402 (56%), Gaps = 17/402 (4%)

Query: 304 YEFTD----PGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQ 359
           +EF D      H   +L+  N+ R ++ FTD+ I VEG+EF  H+ VL++CS YF+ +  
Sbjct: 37  HEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFC 96

Query: 360 RSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTF 419
              ++S    RE L + ++ + A+ +E  L++VYTG + I + N + L E +S FQ    
Sbjct: 97  NDHRES----REML-VEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVL 151

Query: 420 CKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDD 479
              C  FLE+QL   NCLG+   A+      L+   K FALQ F +V+  EE L + KD+
Sbjct: 152 RDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDE 211

Query: 480 FIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
            I Y+ +D L    EE+V+E V++W+ +    R     ELL  VRLP +HP+Y +  V+ 
Sbjct: 212 LIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEV 271

Query: 540 EELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
           ++LI++S  C  L++EA+RYH+L +   EM +PRTRPR S G +EVIV+VGG + VG   
Sbjct: 272 DQLIQNSPECYQLLHEARRYHILGN---EMMSPRTRPRRSTGYSEVIVVVGGCERVG--G 326

Query: 600 RSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSL 659
            +L    C++P   +W  LA LP + +  ++V +  ++I +SGG    +   DVW Y S 
Sbjct: 327 FNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGR---INSRDVWIYNSQ 383

Query: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
           L+ W  V+ +   R RH   V  GK+Y +GG      +  VE
Sbjct: 384 LNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVE 425



 Score = 30.0 bits (66), Expect = 7.6
 Identities = 30/114 (26%), Positives = 54/114 (47%), Gaps = 10/114 (8%)

Query: 584 EVIVLVGGRQMVGMT--QRSLVAVTCWNPQNNKWYPLASLPFYDREFFS---VVSAGDNI 638
           ++ VL+G   +VG    Q  L +V C++  +N+W  +A L    +E  S   V S    +
Sbjct: 401 KMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPL----KEAVSSPAVTSCVGKL 456

Query: 639 YLSGGMESGVTLAD-VWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGL 691
           ++ GG     T +D V  Y    ++W L + + + +    ++  +  IY  GGL
Sbjct: 457 FVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL 510


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score =  223 bits (568), Expect = 5e-58
 Identities = 128/395 (32%), Positives = 210/395 (53%), Gaps = 12/395 (3%)

Query: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
           +P H  +  K +N+ R  +   D+ IV E  E E H+ VLA+CS YF  +      D  +
Sbjct: 29  NPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMF---TGDMSE 85

Query: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
              +K+E+   ++    L  L++++YT  + +   N + LL AAS  Q     + C  FL
Sbjct: 86  SKAKKIEI--KDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFL 143

Query: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
           + QL  +NCLG+ A A+   C++L   A A+A Q FPEV   EE LS+S D   + +S+D
Sbjct: 144 QSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSD 203

Query: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
            L   +EE V+E VI WI  +  TR ++ A+L+  VRLP +   YL+  V+ E LIK++ 
Sbjct: 204 KLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNN 263

Query: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
            C+D + EA +YH+LP   R  ++ PRT+PR    + +V+++VGG+       +++ +V 
Sbjct: 264 TCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQ-----APKAIRSVE 318

Query: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
           C++ + ++W  +A LP   R    VV    ++Y  GG    + +  V  Y  + D W  +
Sbjct: 319 CYDFEEDRWDQIAELP-SRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSI 377

Query: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
           + M   R    + V +  +Y +GG   +  +  VE
Sbjct: 378 ASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVE 412



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 38/135 (28%), Positives = 59/135 (43%), Gaps = 10/135 (7%)

Query: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
           P    R S GV  V   +  VGG    G +++ L  V  +NP  N+W  +A +    R  
Sbjct: 426 PMNTRRSSVGVGVVEGKLYAVGGYD--GASRQCLSTVEQYNPATNEWIYVADMSTR-RSG 482

Query: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
             V      +Y +GG +  +    V  Y    + W  V+ M +  CR N+ V   +G +Y
Sbjct: 483 AGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNM--CRRNAGVCAVNGLLY 540

Query: 687 TLGGLGVAGNVDHVE 701
            +GG   + N+  VE
Sbjct: 541 VVGGDDGSCNLASVE 555


>gi|55925608 kelch-like 21 [Homo sapiens]
          Length = 597

 Score =  223 bits (568), Expect = 5e-58
 Identities = 137/387 (35%), Positives = 210/387 (54%), Gaps = 15/387 (3%)

Query: 306 FTDPGHPREMLKELNQQRRAKAFTDLKI-VVEGREFEVHQNVLASCSLYFKDLIQRSVQD 364
           F+DP H   +L+ L+Q R  + F D+ +    GR+F  H+ VLA+ S YF+ +       
Sbjct: 12  FSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMF------ 65

Query: 365 SGQGGREKLELV-LSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVC 423
           +GQ    + E V L  +  D+L+LLL+F YTG + +   NA+ LL AA   QF    + C
Sbjct: 66  AGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125

Query: 424 VSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQE-EILSISKDDFIA 482
            +FL++QL  +NCL +   AEA  CS L   A+ F L+   E+ A++ E L +++   + 
Sbjct: 126 GAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR--LLR 183

Query: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
           Y+ +D L    EE  Y+  ++W++ DP  R  +  +LL  VRLPF+   YLL  V+ E L
Sbjct: 184 YLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPL 243

Query: 543 IKSSEACRDLVNEAKRYHMLPHARQEM-QTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS 601
           +     C  L+ EA+ +    + R +    PR RPR S G+AE++VLVGG          
Sbjct: 244 VARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGG---CDQDCDE 300

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
           LV V C+NPQ  +W  LA  P +    +S+V+ G++IY++GG +       VW Y S ++
Sbjct: 301 LVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN 360

Query: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTL 688
            W  V+ M   R  H+S V DG +Y +
Sbjct: 361 EWAEVAPMLKAREYHSSSVLDGLLYVV 387



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 2/76 (2%)

Query: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLAD-VWCYMSLLDNW 663
           V  +NP  N+W  + S+        S+   G  +Y+SGG ++   L+D V  Y      W
Sbjct: 482 VDVYNPTRNEWDKIPSMNQV-HVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW 540

Query: 664 NLVSRMTVPRCRHNSL 679
           ++V R+  P   H S+
Sbjct: 541 SVVGRLPEPTFWHGSV 556


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score =  222 bits (565), Expect = 1e-57
 Identities = 138/444 (31%), Positives = 207/444 (46%), Gaps = 11/444 (2%)

Query: 259 GPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKE 318
           GP  PPPPP QP A            P       +Q+L   G          H  +    
Sbjct: 23  GPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLLSREG-HSVAHNSKRHYHDAFVA 81

Query: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
           +++ R+     D+ + V  +E   H+ VLASCS YF  +    + +S Q       + L 
Sbjct: 82  MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQ-----THVTLH 136

Query: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
           ++    L+ L++F YT  +V+   N +TLL AAS  Q +     C  FL  QL  SNCLG
Sbjct: 137 DIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLG 196

Query: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
           +   A+A  CS+L   A  + LQ F +VA  EE + +     +  VS+DSLN  +EE VY
Sbjct: 197 IRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVY 256

Query: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
             V+ W+K D   R Q+   L+  VRLP +   +LL  VD E L++    C+DL+ EA +
Sbjct: 257 RAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALK 316

Query: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
           +H+LP  R  + T RTRPR   G   V+  VGG  +  +          ++ + ++W+ +
Sbjct: 317 FHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG----DCEAYDTRTDRWHVV 372

Query: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
           AS+    R    V + G+ +Y  GG +    LA V  Y  + + W     M   R     
Sbjct: 373 ASMS-TRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGV 431

Query: 679 LVYDGKIYTLGGLGVAGNVDHVER 702
               G +Y+ GG   A  ++  ER
Sbjct: 432 AALHGLLYSAGGYDGASCLNSAER 455



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 42/152 (27%), Positives = 64/152 (42%), Gaps = 7/152 (4%)

Query: 553 VNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS--LVAVTCWNP 610
           +N A+RY  L      +    TR R       V  L G    VG    S  L  V  + P
Sbjct: 450 LNSAERYDPLTGTWTSVAAMSTRRRY----VRVATLDGNLYAVGGYDSSSHLATVEKYEP 505

Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
           Q N W P+AS+    R    V      +Y++GG +    L  V  Y      W  V+ M 
Sbjct: 506 QVNVWSPVASM-LSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMN 564

Query: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
           + R  H+ +  DG +Y +GG   + +++ +E+
Sbjct: 565 IRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEK 596


>gi|11056006 kelch-like 12 [Homo sapiens]
          Length = 568

 Score =  219 bits (559), Expect = 5e-57
 Identities = 134/395 (33%), Positives = 202/395 (51%), Gaps = 14/395 (3%)

Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
           H + +L  +N  R++    D+ + VE ++F  H+ VLA+CS YF  +    + + G    
Sbjct: 15  HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKG---- 70

Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
            K  + +  L A  +E+LL+FVYT ++ +   N + LL AA   Q     + C  FLE Q
Sbjct: 71  -KPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129

Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
           L  SNCLG+   AE   C +L   A+ F+ + FPEV   EE + +S+ +    +  D + 
Sbjct: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189

Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
             +EE V+E VI W+K     R +    LL  VR+P + P Y+ +V+D E  I+ S  CR
Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249

Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
           DLV+EAK++H+ P  R +MQ PRTR RL  G  EV+++VGG    G  Q  +  V  ++P
Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARL--GANEVLLVVGG---FGSQQSPIDVVEKYDP 304

Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDN---WNLVS 667
           +  +W  L S+    R + + VS  D IY+ GG +    L+ V C     D    W  V+
Sbjct: 305 KTQEWSFLPSIT-RKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVA 363

Query: 668 RMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
            M V R    +      IY  GG   +     +ER
Sbjct: 364 PMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMER 398



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 35/123 (28%), Positives = 55/123 (44%), Gaps = 6/123 (4%)

Query: 568 EMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDRE 627
           +MQT R    L    + VI  +GG   + +    L +V  ++P    W  +  +    R 
Sbjct: 411 DMQTAREGAGLVVA-SGVIYCLGGYDGLNI----LNSVEKYDPHTGHWTNVTPMAT-KRS 464

Query: 628 FFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYT 687
              V    D+IY+ GG +    L+ V  Y    D+W  V+ MT PRC   + V  G++Y 
Sbjct: 465 GAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYA 524

Query: 688 LGG 690
           + G
Sbjct: 525 IAG 527



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 32/128 (25%), Positives = 55/128 (42%), Gaps = 11/128 (8%)

Query: 551 DLVNEAKRYHMLPHARQEMQ-TPRTRPRLSAGVA---EVIVLVGGRQMVGMTQRSLVAVT 606
           +++N  ++Y   PH       TP    R  AGVA   + I +VGG          L +V 
Sbjct: 438 NILNSVEKYD--PHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA----HLSSVE 491

Query: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
            +N + + W  + S+    R +         +Y   G +    L+ + CY  ++D+W +V
Sbjct: 492 AYNIRTDSWTTVTSMTT-PRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVV 550

Query: 667 SRMTVPRC 674
           + M   RC
Sbjct: 551 TSMGTQRC 558



 Score = 30.0 bits (66), Expect = 7.6
 Identities = 24/94 (25%), Positives = 38/94 (40%), Gaps = 1/94 (1%)

Query: 608 WNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVS 667
           ++P  ++W  L  +    RE   +V A   IY  GG +    L  V  Y     +W  V+
Sbjct: 399 YDPNIDQWSMLGDMQTA-REGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVT 457

Query: 668 RMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
            M   R      + +  IY +GG     ++  VE
Sbjct: 458 PMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVE 491


>gi|55925604 kelch-like 18 [Homo sapiens]
          Length = 574

 Score =  217 bits (553), Expect = 3e-56
 Identities = 128/383 (33%), Positives = 188/383 (49%), Gaps = 9/383 (2%)

Query: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
           + + RR     D+ + +   +F  H+ VLA+   YF  +    + +  Q      E+V+ 
Sbjct: 28  MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQD-----EIVMQ 82

Query: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
            +    LE L+ F Y G+L ID  N ++LL  AS  Q  +    C +FL ++L   NCLG
Sbjct: 83  GMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLG 142

Query: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
           V   AE M C+ LY  A +F  Q F EV+  EE L++  +D +  VS D LN K+EE V+
Sbjct: 143 VRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVF 202

Query: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
           E  + W++ D   R  Y  ELL+ +RLP   P +L + V  ++L++    CRDLV+EAK 
Sbjct: 203 EAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKD 262

Query: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
           YH++P  R  +   RTRPR    +A +I  VGG    G    SL  V  ++P  N W   
Sbjct: 263 YHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAG---DSLNVVEVFDPIANCWERC 319

Query: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
             +    R    V      +Y  GG +  + L+ V  Y    D W  V  M   R    +
Sbjct: 320 RPMT-TARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGT 378

Query: 679 LVYDGKIYTLGGLGVAGNVDHVE 701
           +V DG+IY  GG     ++  VE
Sbjct: 379 VVLDGQIYVCGGYDGNSSLSSVE 401



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 26/98 (26%), Positives = 43/98 (43%), Gaps = 1/98 (1%)

Query: 604 AVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNW 663
           +V  +N     W+P A +    R      S G  +++ GG +    L+    Y S+ D W
Sbjct: 446 SVEHYNHHTATWHPAAGM-LNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQW 504

Query: 664 NLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
            L+  M   R R + +   G++Y +GG     N+  VE
Sbjct: 505 CLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVE 542



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 1/95 (1%)

Query: 601 SLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLL 660
           SL +V  ++P+ +KW  + S+   +R    V      IY+SGG +     + V  Y    
Sbjct: 396 SLSSVETYSPETDKWTVVTSMSS-NRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHT 454

Query: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG 695
             W+  + M   RCRH +     K++  GG   +G
Sbjct: 455 ATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSG 489


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score =  216 bits (551), Expect = 4e-56
 Identities = 131/393 (33%), Positives = 204/393 (51%), Gaps = 11/393 (2%)

Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
           HPR+ L+ +N  R+ +   D+ +VV  ++   H+ +L++CS YF+ +    + +S Q   
Sbjct: 50  HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQ--- 106

Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
              E+V+ ++    +ELL++F YT  + ++  N +TLL AA   Q     + C  FL++Q
Sbjct: 107 --TEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQ 164

Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
           L  SNCLG+ A A+   C EL  +A  F    F EV   EE + +  +  I  +S+D LN
Sbjct: 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELN 224

Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
            ++EE V+  V+ W+K     R     ++L  VRLP + P +L+  V ++ LIKS E CR
Sbjct: 225 VRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECR 284

Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
           DLV+EAK Y +LP  R  MQ PRTRPR      EV+  VGG      +  ++ +V  ++P
Sbjct: 285 DLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGG----WCSGDAISSVERYDP 340

Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNL-VSRM 669
           Q N+W  +AS+    R    V    D +Y  GG +    L  V  Y    + W+  V+  
Sbjct: 341 QTNEWRMVASMS-KRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPT 399

Query: 670 TVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
           +  R      V  G +Y +GG      ++ VER
Sbjct: 400 STCRTSVGVAVLGGFLYAVGGQDGVSCLNIVER 432



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 41/153 (26%), Positives = 62/153 (40%), Gaps = 8/153 (5%)

Query: 553 VNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWN 609
           +N  +RY    +       P +  R S GVA +   +  VGG+  V      L  V  ++
Sbjct: 379 LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSC----LNIVERYD 434

Query: 610 PQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRM 669
           P+ NKW  +AS+    R   +V   G  +Y  GG +    L  V  Y    + W+ ++ M
Sbjct: 435 PKENKWTRVASMSTR-RLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPM 493

Query: 670 TVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
              R      VY   IY +GG      +   ER
Sbjct: 494 GTRRKHLGCAVYQDMIYAVGGRDDTTELSSAER 526



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 39/140 (27%), Positives = 60/140 (42%), Gaps = 7/140 (5%)

Query: 553 VNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS--LVAVTCWNP 610
           +N  +RY    +    + +  TR RL   VA   VL G    VG +  +  L  V  +NP
Sbjct: 427 LNIVERYDPKENKWTRVASMSTR-RLGVAVA---VLGGFLYAVGGSDGTSPLNTVERYNP 482

Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
           Q N+W+ +A +    R+        D IY  GG +    L+    Y    + W+ V  MT
Sbjct: 483 QENRWHTIAPMGTR-RKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMT 541

Query: 671 VPRCRHNSLVYDGKIYTLGG 690
             R      V +G++  +GG
Sbjct: 542 SRRSGVGLAVVNGQLMAVGG 561


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score =  209 bits (532), Expect = 7e-54
 Identities = 124/395 (31%), Positives = 203/395 (51%), Gaps = 12/395 (3%)

Query: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
           +P H ++  K +N+ R      D+ IV E  E   H+ VLA+CS YF  +    + +S  
Sbjct: 39  NPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSES-- 96

Query: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
             R K  + +  +    L +L+++VYT  + +   N + LL AA   Q     K C  FL
Sbjct: 97  --RAK-RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 153

Query: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
           E QL   NCLG+ A A+   C++L + A  +A Q F +V   EE L++  +   + +S+D
Sbjct: 154 ESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSD 213

Query: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
            L   +EE V+E VI W+  D   R ++ A L+  VRLP +   YL+  V+ E L+K+S 
Sbjct: 214 KLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSS 273

Query: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
           AC+D + EA +YH+LP   R  M++ RTR R    + +++V+VGG+       +++ +V 
Sbjct: 274 ACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVE 328

Query: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
           C++ +  +W+ +A LP        V  AG  ++  GG    + +  V  Y  + D W  V
Sbjct: 329 CYDFKEERWHQVAELPSRRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSV 387

Query: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
           + M   R    + V +G +Y +GG   +  +  VE
Sbjct: 388 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVE 422



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 38/135 (28%), Positives = 59/135 (43%), Gaps = 10/135 (7%)

Query: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
           P    R S GV  V   +  VGG    G +++ L  V C+N   N+W  +A +    R  
Sbjct: 436 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMS-TRRSG 492

Query: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
             V    + +Y  GG +  +    V  Y    + W  V+ M +  CR N+ V   +G +Y
Sbjct: 493 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 550

Query: 687 TLGGLGVAGNVDHVE 701
            +GG   + N+  VE
Sbjct: 551 VVGGDDGSCNLASVE 565



 Score = 36.6 bits (83), Expect = 0.082
 Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME--SGVTLADVWCYMSL 659
           L +V  +N ++N+W+ +A +    R    V   G  +Y  GG +  S   L+ V CY + 
Sbjct: 418 LSSVEAYNIKSNEWFHVAPMNTR-RSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNAT 476

Query: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            + W  ++ M+  R      V +  +Y +GG
Sbjct: 477 TNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 507


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score =  209 bits (532), Expect = 7e-54
 Identities = 124/395 (31%), Positives = 203/395 (51%), Gaps = 12/395 (3%)

Query: 308 DPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQ 367
           +P H ++  K +N+ R      D+ IV E  E   H+ VLA+CS YF  +    + +S  
Sbjct: 35  NPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSES-- 92

Query: 368 GGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFL 427
             R K  + +  +    L +L+++VYT  + +   N + LL AA   Q     K C  FL
Sbjct: 93  --RAK-RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 149

Query: 428 EKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSND 487
           E QL   NCLG+ A A+   C++L + A  +A Q F +V   EE L++  +   + +S+D
Sbjct: 150 ESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSD 209

Query: 488 SLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSE 547
            L   +EE V+E VI W+  D   R ++ A L+  VRLP +   YL+  V+ E L+K+S 
Sbjct: 210 KLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSS 269

Query: 548 ACRDLVNEAKRYHMLP-HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVT 606
           AC+D + EA +YH+LP   R  M++ RTR R    + +++V+VGG+       +++ +V 
Sbjct: 270 ACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVE 324

Query: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
           C++ +  +W+ +A LP        V  AG  ++  GG    + +  V  Y  + D W  V
Sbjct: 325 CYDFKEERWHQVAELPSRRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSV 383

Query: 667 SRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
           + M   R    + V +G +Y +GG   +  +  VE
Sbjct: 384 ANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVE 418



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 38/135 (28%), Positives = 59/135 (43%), Gaps = 10/135 (7%)

Query: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
           P    R S GV  V   +  VGG    G +++ L  V C+N   N+W  +A +    R  
Sbjct: 432 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMS-TRRSG 488

Query: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
             V    + +Y  GG +  +    V  Y    + W  V+ M +  CR N+ V   +G +Y
Sbjct: 489 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 546

Query: 687 TLGGLGVAGNVDHVE 701
            +GG   + N+  VE
Sbjct: 547 VVGGDDGSCNLASVE 561



 Score = 36.6 bits (83), Expect = 0.082
 Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME--SGVTLADVWCYMSL 659
           L +V  +N ++N+W+ +A +    R    V   G  +Y  GG +  S   L+ V CY + 
Sbjct: 414 LSSVEAYNIKSNEWFHVAPMNTR-RSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNAT 472

Query: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            + W  ++ M+  R      V +  +Y +GG
Sbjct: 473 TNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 503


>gi|109150407 kelch-like 6 [Homo sapiens]
          Length = 621

 Score =  201 bits (511), Expect = 2e-51
 Identities = 122/433 (28%), Positives = 212/433 (48%), Gaps = 27/433 (6%)

Query: 278 APATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEG 337
           AP+T+ P          ++  +   K +F D G    +   L   R   A TD+ + V+ 
Sbjct: 25  APSTDEPSQKTG----DLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDI 80

Query: 338 REFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSL 397
           +EF  H+ VLA+ S YF+ +    +++     + +  +++  + A+ +  LL++ YT   
Sbjct: 81  QEFSCHRVVLAAASNYFRAMFCNDLKE-----KYEKRIIIKGVDAETMHTLLDYTYTSKA 135

Query: 398 VIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKA 457
           +I   N + +LEAA+ FQF      C SFL + L   NC+G+L +A+      L    ++
Sbjct: 136 LITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQS 195

Query: 458 FALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAA 517
           + +Q F ++   EE L +  D     + +D L    E  V+ETV+ W++  P+ R     
Sbjct: 196 YIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLP 255

Query: 518 ELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPR 577
            +L  VRLP + P Y +  V+ + LI+       L+ EA+ YH+   +  E+ + RT+PR
Sbjct: 256 YVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL---SGNEIISERTKPR 312

Query: 578 LSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF--------- 628
           +    +EV +++GG       +R +  VTC +P       +A LP  + E          
Sbjct: 313 MHEFQSEVFMIIGG---CTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVE 369

Query: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTL 688
           F+ V+  + +Y+SGG E   T  DVW Y S ++ W  +  + + R RH  +V  GK+Y +
Sbjct: 370 FACVTLKNEVYISGGKE---TQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVI 426

Query: 689 GGLGVAGNVDHVE 701
           GG      +++VE
Sbjct: 427 GGFDGLQRINNVE 439



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 6/84 (7%)

Query: 607 CWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLV 666
           C++P  NKW   A++P  + +  + VS  D IY+ GG      +  ++ Y  L D+W LV
Sbjct: 488 CYDPSTNKWSLKAAMPV-EAKCINAVSFRDRIYVVGG-----AMRALYAYSPLEDSWCLV 541

Query: 667 SRMTVPRCRHNSLVYDGKIYTLGG 690
           ++++  R        + ++Y  GG
Sbjct: 542 TQLSHERASCGIAPCNNRLYITGG 565



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 2/87 (2%)

Query: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLAD-VWCYMSLLDNW 663
           V  ++P +N W   A L  +   F +  S    +Y+ GG  +G    D   CY    + W
Sbjct: 438 VETYDPFHNCWSEAAPLLVHVSSF-AATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKW 496

Query: 664 NLVSRMTVPRCRHNSLVYDGKIYTLGG 690
           +L + M V     N++ +  +IY +GG
Sbjct: 497 SLKAAMPVEAKCINAVSFRDRIYVVGG 523


>gi|194097389 kelch-like 38 [Homo sapiens]
          Length = 581

 Score =  196 bits (497), Expect = 8e-50
 Identities = 128/399 (32%), Positives = 207/399 (51%), Gaps = 29/399 (7%)

Query: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
           F D     ++L++LN  R+++  TD+ I    RE   H+NVLAS S YF+ +   S ++ 
Sbjct: 11  FKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREK 70

Query: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
            +      ++ L  +    L+ ++ +VYTG   I + N   ++EAAS  QF    + C S
Sbjct: 71  SEA-----KVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSS 125

Query: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
           +L+ QL  SNCLG++ ++E + C  L   A+  AL  FPEVAA  ++  +   +   Y+ 
Sbjct: 126 YLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLG 185

Query: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
           +D L    EE V+E ++ WIK D   R +Y  EL   VRL +IHP++  + + N+ L++S
Sbjct: 186 DDGL-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQS 244

Query: 546 SEACRDLVNEAKRYHM------LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
           S AC+ ++  AKR         +P  +  +  P   PR S    + ++L+GGR+    T 
Sbjct: 245 SPACQIILETAKRQMFSLCGTTVPDCKLLLHVP---PRNS--YQDFLILLGGRKDSQQTT 299

Query: 600 RSLVAVTCWNPQNNKWYPLASLP--FYDREFFSVVSAGDNIYLSGGM--ESGVTLA--DV 653
           R    V  ++ Q  +W  LA LP   Y     S ++   +IY+ GGM   SG +L   +V
Sbjct: 300 RD---VLLYSKQTGQWQSLAKLPTRLYKA---SAITLHRSIYVLGGMAVSSGRSLVSHNV 353

Query: 654 WCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLG 692
           + +   L+ W L   M V R  H S  +   I+++GG+G
Sbjct: 354 YIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIG 392


>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
          Length = 571

 Score =  189 bits (480), Expect = 8e-48
 Identities = 126/403 (31%), Positives = 195/403 (48%), Gaps = 25/403 (6%)

Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
           H  ++L+ LN  R+     D+ + V   +   H+ VLAS S YFK +   ++ +     +
Sbjct: 17  HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSE-----K 71

Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
           E  E+    +    L+ ++E+ YTG++ I     ++LL AA+  Q     K C +FLE Q
Sbjct: 72  ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131

Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
           L   NC+G+   AE   C +LY  A  +  Q F  V   EE   ++  D    VSND LN
Sbjct: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191

Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
              EE V+  +  WIK D   R +Y A+LL  VRLP +   +L  + +   LI+    C+
Sbjct: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251

Query: 551 DLVNEAKRYHMLPHARQEMQTP-RTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWN 609
            L+NEA +YH +P  R   QT   TRPR +    +V+  VGG+  +      L +V  + 
Sbjct: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCA---PKVLCAVGGKSGL---FACLDSVEMYF 305

Query: 610 PQNNKWYPLA--SLPFYDREFFSVVSAGDNIYLSGGMES----GVTLA----DVWCYMSL 659
           PQN+ W  LA  ++P Y+   F +      +Y+ GG+ +    GVT+      V C+   
Sbjct: 306 PQNDSWIGLAPLNIPRYE---FGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPD 362

Query: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
            + W  + RM   R     +V  G++Y LGG      +  VE+
Sbjct: 363 TNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEK 405



 Score = 31.2 bits (69), Expect = 3.4
 Identities = 31/130 (23%), Positives = 55/130 (42%), Gaps = 7/130 (5%)

Query: 574 TRPRLSAGVAE-VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVV 632
           TR   +A V + +I  +GG     M      +V  ++P  + W  +AS+      F   V
Sbjct: 422 TRSCFAAAVLDGMIYAIGGYGPAHMN-----SVERYDPSKDSWEMVASMADKRIHFGVGV 476

Query: 633 SAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLG 692
             G  I++ GG      L+ +  Y    + W +   M  PR    + V D  +Y +GG  
Sbjct: 477 MLGF-IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS 535

Query: 693 VAGNVDHVER 702
            +  ++ V++
Sbjct: 536 GSSYLNTVQK 545


>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
          Length = 586

 Score =  186 bits (473), Expect = 5e-47
 Identities = 118/415 (28%), Positives = 197/415 (47%), Gaps = 54/415 (13%)

Query: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
           +N  R+ K   D+ ++V+ R+   H+ VLA+ S +F  +   ++ +S     +  E+ L 
Sbjct: 34  MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-----KSFEVELK 88

Query: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
           + + D++E L+EF YT  + ++S N ++LL+AA+++Q     K+CV FL++Q+ ASNCLG
Sbjct: 89  DAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLG 148

Query: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
           +  +AE + C EL   A  F  Q F EV   +E L +        ++ D+L  +AE+ VY
Sbjct: 149 ISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVY 208

Query: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
           +  ++W+K D   R  +  ++LA VR P I  ++L   V  E LI+ +  C  +V    R
Sbjct: 209 DAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMR 268

Query: 559 YHMLPHARQEMQTPRTRPR---------LSAGVA-------------------------- 583
           YH+L    +E     TRPR         L  G                            
Sbjct: 269 YHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRD 328

Query: 584 -------EVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGD 636
                   V+ ++GG Q+  + +     + C+N   + WY     P   R+  +  +A  
Sbjct: 329 AACVFWDNVVYILGGSQLFPIKR-----MDCYNVVKDSWYSKLGPP-TPRDSLAACAAEG 382

Query: 637 NIYLSGGMESGVTLADVW-CYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            IY SGG E G +   ++ CY +  ++W+    M   RC H  +  +G IY  GG
Sbjct: 383 KIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGG 437



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 34/140 (24%), Positives = 53/140 (37%), Gaps = 8/140 (5%)

Query: 564 HARQEMQTPRTRPRLSAGVAE---VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
           H +  M T R     S G+ E   +I + GG     ++ R L +   ++P    W  L  
Sbjct: 411 HTKPSMLTQRC----SHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 466

Query: 621 LPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
           +    R+   +V   D I+  GG      L +V  Y   L+ W +VS M           
Sbjct: 467 M-IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAA 525

Query: 681 YDGKIYTLGGLGVAGNVDHV 700
               +Y L G    G + H+
Sbjct: 526 VGSIVYVLAGFQGVGRLGHI 545


>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
          Length = 709

 Score =  186 bits (471), Expect = 8e-47
 Identities = 117/427 (27%), Positives = 206/427 (48%), Gaps = 17/427 (3%)

Query: 276 SGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVV 335
           S    +N   T  S H ++   +       F    H  +  K++    R K   D+ +V 
Sbjct: 125 SSCRTSNSSQTLSSCHTMEPCTSDEF----FQALNHAEQTFKKMENYLRHKQLCDVILVA 180

Query: 336 EGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTG 395
             R    H+ VL+S S YF  +    V+++ Q      E+ +  ++ + L  L+++ YTG
Sbjct: 181 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQE-----EIKMEGVEPNSLWSLIQYAYTG 235

Query: 396 SLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMA 455
            L +   N + LL  A   Q     + C  FL KQL  SNCLG+ + A+A  C++L+ +A
Sbjct: 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVA 295

Query: 456 KAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQY 515
             + ++ F EV   +E + +   +    +++D +N   EE +   ++ W++ D   R + 
Sbjct: 296 HNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD 355

Query: 516 AAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTR 575
            ++LLA +RLP + P +L + ++N  L +    C+ L+ EA +YH+LP  R  +Q+PRT+
Sbjct: 356 LSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTK 414

Query: 576 PRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAG 635
           PR S      +  VGG      + +   ++  ++ + N W P+A++    R  F V    
Sbjct: 415 PRKS--TVGTLFAVGGMD----STKGATSIEKYDLRTNMWTPVANMN-GRRLQFGVAVLD 467

Query: 636 DNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG 695
           D +Y+ GG +   TL  V CY      W+++  M+  R      V +G +Y +GG     
Sbjct: 468 DKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 527

Query: 696 NVDHVER 702
            ++ VER
Sbjct: 528 YLNTVER 534



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 33/121 (27%), Positives = 50/121 (41%), Gaps = 6/121 (4%)

Query: 572 PRTRPRLSAGVAEVIVLVGGRQMVGMTQ--RSLVAVTCWNPQNNKWYPLASLPFYDREFF 629
           P +  R   GVA   VL G    VG       L  V  W+PQ  +W  +A++    R   
Sbjct: 500 PMSTHRHGLGVA---VLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMST-PRSTV 555

Query: 630 SVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLG 689
            V      +Y  GG +    L  V C+    + W L ++M+  R       ++G +Y +G
Sbjct: 556 GVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG 615

Query: 690 G 690
           G
Sbjct: 616 G 616



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 15/149 (10%)

Query: 563 PHARQ-EMQTPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
           P ARQ       + PR + GVA +   +  VGGR         L +V C++P  NKW   
Sbjct: 537 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD----GSSCLKSVECFDPHTNKWTLC 592

Query: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVT-----LAD-VWCYMSLLDNWNLVSRMTVP 672
           A +    R    V +    +Y  GG ++  +     L+D V  Y    D W  V+ M++ 
Sbjct: 593 AQMS-KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSIS 651

Query: 673 RCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
           R      +   K+Y +GG      ++ VE
Sbjct: 652 RDAVGVCLLGDKLYAVGGYDGQAYLNTVE 680



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 20/77 (25%), Positives = 34/77 (44%), Gaps = 1/77 (1%)

Query: 597 MTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCY 656
           +T R    V  ++P+ + W  +AS+    R+   V   GD +Y  GG +    L  V  Y
Sbjct: 624 LTSRLSDCVERYDPKTDMWTAVASMSI-SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 682

Query: 657 MSLLDNWNLVSRMTVPR 673
               + W  V+ + + R
Sbjct: 683 DPQTNEWTQVAPLCLGR 699


>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
          Length = 755

 Score =  186 bits (471), Expect = 8e-47
 Identities = 117/427 (27%), Positives = 206/427 (48%), Gaps = 17/427 (3%)

Query: 276 SGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVV 335
           S    +N   T  S H ++   +       F    H  +  K++    R K   D+ +V 
Sbjct: 171 SSCRTSNSSQTLSSCHTMEPCTSDEF----FQALNHAEQTFKKMENYLRHKQLCDVILVA 226

Query: 336 EGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTG 395
             R    H+ VL+S S YF  +    V+++ Q      E+ +  ++ + L  L+++ YTG
Sbjct: 227 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQE-----EIKMEGVEPNSLWSLIQYAYTG 281

Query: 396 SLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMA 455
            L +   N + LL  A   Q     + C  FL KQL  SNCLG+ + A+A  C++L+ +A
Sbjct: 282 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVA 341

Query: 456 KAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQY 515
             + ++ F EV   +E + +   +    +++D +N   EE +   ++ W++ D   R + 
Sbjct: 342 HNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD 401

Query: 516 AAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTR 575
            ++LLA +RLP + P +L + ++N  L +    C+ L+ EA +YH+LP  R  +Q+PRT+
Sbjct: 402 LSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTK 460

Query: 576 PRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAG 635
           PR S      +  VGG      + +   ++  ++ + N W P+A++    R  F V    
Sbjct: 461 PRKS--TVGTLFAVGGMD----STKGATSIEKYDLRTNMWTPVANMN-GRRLQFGVAVLD 513

Query: 636 DNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAG 695
           D +Y+ GG +   TL  V CY      W+++  M+  R      V +G +Y +GG     
Sbjct: 514 DKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 573

Query: 696 NVDHVER 702
            ++ VER
Sbjct: 574 YLNTVER 580



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 33/121 (27%), Positives = 50/121 (41%), Gaps = 6/121 (4%)

Query: 572 PRTRPRLSAGVAEVIVLVGGRQMVGMTQ--RSLVAVTCWNPQNNKWYPLASLPFYDREFF 629
           P +  R   GVA   VL G    VG       L  V  W+PQ  +W  +A++    R   
Sbjct: 546 PMSTHRHGLGVA---VLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMST-PRSTV 601

Query: 630 SVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLG 689
            V      +Y  GG +    L  V C+    + W L ++M+  R       ++G +Y +G
Sbjct: 602 GVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG 661

Query: 690 G 690
           G
Sbjct: 662 G 662



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 15/149 (10%)

Query: 563 PHARQ-EMQTPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
           P ARQ       + PR + GVA +   +  VGGR         L +V C++P  NKW   
Sbjct: 583 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD----GSSCLKSVECFDPHTNKWTLC 638

Query: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVT-----LAD-VWCYMSLLDNWNLVSRMTVP 672
           A +    R    V +    +Y  GG ++  +     L+D V  Y    D W  V+ M++ 
Sbjct: 639 AQMS-KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSIS 697

Query: 673 RCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
           R      +   K+Y +GG      ++ VE
Sbjct: 698 RDAVGVCLLGDKLYAVGGYDGQAYLNTVE 726



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 20/77 (25%), Positives = 34/77 (44%), Gaps = 1/77 (1%)

Query: 597 MTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCY 656
           +T R    V  ++P+ + W  +AS+    R+   V   GD +Y  GG +    L  V  Y
Sbjct: 670 LTSRLSDCVERYDPKTDMWTAVASMSI-SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 728

Query: 657 MSLLDNWNLVSRMTVPR 673
               + W  V+ + + R
Sbjct: 729 DPQTNEWTQVAPLCLGR 745


>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
           sapiens]
          Length = 589

 Score =  185 bits (470), Expect = 1e-46
 Identities = 125/391 (31%), Positives = 200/391 (51%), Gaps = 20/391 (5%)

Query: 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQ 363
           Y F    +   +L  LN  R+ + FTD+ +    R F  H+ VLA+CS YF+ +    ++
Sbjct: 21  YLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLK 80

Query: 364 DSGQGGREKLELVLSN-LQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
           +S     +  E+   N +  +VLELLL++ Y+  ++I+  NA++LLEA    +F      
Sbjct: 81  ES-----QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDA 135

Query: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
           C  FLEK L  +NCLG+L +++A QC++LY ++    L  F  +   E+ L + +D  + 
Sbjct: 136 CAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQ 195

Query: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
            +S++ L T+ E LVYE+ I WI  D   R  Y  ELL  VRL  +   YL+  V  EEL
Sbjct: 196 LLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEEL 255

Query: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPR-TRPRLSAGVAEVIVLVGGRQMVGMTQRS 601
           I      +++V EA R  +       + T    RPR +      + L+GG+  +   +  
Sbjct: 256 ITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKT---GHALFLLGGQTFM-CDKLY 311

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSG--GMESGVTLADVWCYMSL 659
           LV     + +  +  P A +P   R+ FS  + G  +Y++G  G E+GV+  DVW Y +L
Sbjct: 312 LV-----DQKAKEIIPKADIP-SPRKEFSACAIGCKVYITGGRGSENGVS-KDVWVYDTL 364

Query: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            + W+  + M V R  H S      +Y +GG
Sbjct: 365 HEEWSKAAPMLVARFGHGSAELKHCLYVVGG 395



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 21/89 (23%), Positives = 41/89 (46%), Gaps = 2/89 (2%)

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
           L  V C++   N+W   A+ P   R + +    G+ I++ GG ++  +    + + S   
Sbjct: 459 LPKVQCYDQCENRWTVPATCPQPWR-YTAAAVLGNQIFIMGG-DTEFSACSAYKFNSETY 516

Query: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            W  V  +T  R   +++    K+Y +GG
Sbjct: 517 QWTKVGDVTAKRMSCHAVASGNKLYVVGG 545


>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
          Length = 589

 Score =  184 bits (468), Expect = 2e-46
 Identities = 122/388 (31%), Positives = 196/388 (50%), Gaps = 18/388 (4%)

Query: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
           F    HP  +L  LN  R+   FTD+ +    R F  H+ VLA+ S YF+ +    +++S
Sbjct: 23  FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82

Query: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
               R+       NL  +VLELLL+F Y+  + I+  NA++LLEA    QFH        
Sbjct: 83  ----RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAE 138

Query: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
           FLEK L  SNCLG++ +++A QC  LY  +    L  F  V   E+  S+SKD  +  +S
Sbjct: 139 FLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLIS 198

Query: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
           +D L T+ E +V+E +++W+K D   R  +  ELL  VRL  +    L   V +E L+ +
Sbjct: 199 SDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMA 258

Query: 546 SEACRDLVNEAKRYHMLPHARQEMQT-PRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVA 604
            E  + +++EA R          + T P  RPR +      ++++GG+  +         
Sbjct: 259 DERTKLIMDEALRCKTRILQNDGVVTSPCARPRKA---GHTLLILGGQTFM------CDK 309

Query: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSG--GMESGVTLADVWCYMSLLDN 662
           +   + +  +  P A LP   R+ FS  + G  +Y++G  G E+GV+  DVW Y ++ + 
Sbjct: 310 IYQVDHKAKEIIPKADLP-SPRKEFSASAIGCKVYVTGGRGSENGVS-KDVWVYDTVHEE 367

Query: 663 WNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
           W+  + M + R  H S   +  +Y +GG
Sbjct: 368 WSKAAPMLIARFGHGSAELENCLYVVGG 395



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 2/86 (2%)

Query: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWN 664
           V C++P  N+W   A  P   R + +    G  I++ GG ++  T A  + +    + W 
Sbjct: 462 VQCYDPSENRWTIKAECPQPWR-YTAAAVLGSQIFIMGG-DTEFTAASAYRFDCETNQWT 519

Query: 665 LVSRMTVPRCRHNSLVYDGKIYTLGG 690
            +  MT  R   ++L    K+Y +GG
Sbjct: 520 RIGDMTAKRMSCHALASGNKLYVVGG 545


>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
          Length = 505

 Score =  181 bits (460), Expect = 2e-45
 Identities = 103/318 (32%), Positives = 168/318 (52%), Gaps = 7/318 (2%)

Query: 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAE 444
           L +L+++VYT  + +   N + LL AA   Q     K C  FLE QL   NCLG+ A A+
Sbjct: 19  LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 78

Query: 445 AMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKW 504
              C++L + A  +A Q F +V   EE L++  +   + +S+D L   +EE V+E VI W
Sbjct: 79  MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 138

Query: 505 IKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLP- 563
           +  D   R ++ A L+  VRLP +   YL+  V+ E L+K+S AC+D + EA +YH+LP 
Sbjct: 139 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPT 198

Query: 564 HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPF 623
             R  M++ RTR R    + +++V+VGG+       +++ +V C++ +  +W+ +A LP 
Sbjct: 199 EQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVECYDFKEERWHQVAELPS 253

Query: 624 YDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDG 683
                  V  AG  ++  GG    + +  V  Y  + D W  V+ M   R    + V +G
Sbjct: 254 RRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNG 312

Query: 684 KIYTLGGLGVAGNVDHVE 701
            +Y +GG   +  +  VE
Sbjct: 313 LLYAVGGFDGSTGLSSVE 330



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 38/135 (28%), Positives = 59/135 (43%), Gaps = 10/135 (7%)

Query: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
           P    R S GV  V   +  VGG    G +++ L  V C+N   N+W  +A +    R  
Sbjct: 344 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMS-TRRSG 400

Query: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
             V    + +Y  GG +  +    V  Y    + W  V+ M +  CR N+ V   +G +Y
Sbjct: 401 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 458

Query: 687 TLGGLGVAGNVDHVE 701
            +GG   + N+  VE
Sbjct: 459 VVGGDDGSCNLASVE 473



 Score = 36.6 bits (83), Expect = 0.082
 Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME--SGVTLADVWCYMSL 659
           L +V  +N ++N+W+ +A +    R    V   G  +Y  GG +  S   L+ V CY + 
Sbjct: 326 LSSVEAYNIKSNEWFHVAPMNTR-RSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNAT 384

Query: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            + W  ++ M+  R      V +  +Y +GG
Sbjct: 385 TNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 415


>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
          Length = 564

 Score =  181 bits (459), Expect = 2e-45
 Identities = 116/408 (28%), Positives = 193/408 (47%), Gaps = 54/408 (13%)

Query: 326 KAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVL 385
           K   D+ ++V+ R+   H+ VLA+ S +F  +   ++ +S     +  E+ L + + D++
Sbjct: 19  KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-----KSFEVELKDAEPDII 73

Query: 386 ELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEA 445
           E L+EF YT  + ++S N ++LL+AA+++Q     K+CV FL++Q+ ASNCLG+  +AE 
Sbjct: 74  EQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAEC 133

Query: 446 MQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWI 505
           + C EL   A  F  Q F EV   +E L +        ++ D+L  +AE+ VY+  ++W+
Sbjct: 134 LDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWL 193

Query: 506 KKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHA 565
           K D   R  +  ++LA VR P I  ++L   V  E LI+ +  C  +V    RYH+L   
Sbjct: 194 KYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPE 253

Query: 566 RQEMQTPRTRPR---------LSAGVA--------------------------------- 583
            +E     TRPR         L  G                                   
Sbjct: 254 DREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWD 313

Query: 584 EVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGG 643
            V+ ++GG Q+  + +     + C+N   + WY     P   R+  +  +A   IY SGG
Sbjct: 314 NVVYILGGSQLFPIKR-----MDCYNVVKDSWYSKLGPP-TPRDSLAACAAEGKIYTSGG 367

Query: 644 MESGVTLADVW-CYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            E G +   ++ CY +  ++W+    M   RC H  +  +G IY  GG
Sbjct: 368 SEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGG 415



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 34/140 (24%), Positives = 53/140 (37%), Gaps = 8/140 (5%)

Query: 564 HARQEMQTPRTRPRLSAGVAE---VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
           H +  M T R     S G+ E   +I + GG     ++ R L +   ++P    W  L  
Sbjct: 389 HTKPSMLTQRC----SHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 444

Query: 621 LPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
           +    R+   +V   D I+  GG      L +V  Y   L+ W +VS M           
Sbjct: 445 M-IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAA 503

Query: 681 YDGKIYTLGGLGVAGNVDHV 700
               +Y L G    G + H+
Sbjct: 504 VGSIVYVLAGFQGVGRLGHI 523


>gi|14780904 kelch-like 1 protein [Homo sapiens]
          Length = 748

 Score =  176 bits (445), Expect = 9e-44
 Identities = 113/392 (28%), Positives = 189/392 (48%), Gaps = 13/392 (3%)

Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
           H  +  +++    + +   D+ ++V  R+   H+ VL+S S YF  +    V ++ Q   
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQE-- 251

Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
              E+ +  +  + L  L++F YTG L +     + LL AA   Q     +VC  FL K 
Sbjct: 252 ---EIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKL 308

Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
           L  SNCLG+ A A+A  C EL  +A ++ ++   EV   +E L +  ++    +++D +N
Sbjct: 309 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVN 368

Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
              EE ++  ++ W+K D  +R    + LLA +RLP + P  L + ++N  L K+   C+
Sbjct: 369 VPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQ 427

Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
            L+ EA +YH+LP  R  MQ+PRT+PR S      +  VGG        +    +  ++ 
Sbjct: 428 KLILEAMKYHLLPERRTLMQSPRTKPRKS--TVGTLYAVGGMD----NNKGATTIEKYDL 481

Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
           + N W   A +    R  F V    D +++ GG +   TL  V CY      W ++  M+
Sbjct: 482 RTNLWIQ-AGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMS 540

Query: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
             R      V +G IY +GG      ++ VER
Sbjct: 541 THRHGLGVTVLEGPIYAVGGHDGWSYLNTVER 572



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 7/107 (6%)

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
           L  V  W+PQ+ +W  +AS+    R    V +    +Y  GG +    L+ +  Y    +
Sbjct: 567 LNTVERWDPQSQQWTFVASMSIA-RSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTN 625

Query: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGN------VDHVER 702
            WN+ + M   R        DG +Y +GG     +      +D+VER
Sbjct: 626 KWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVER 672



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 29/117 (24%), Positives = 46/117 (39%), Gaps = 7/117 (5%)

Query: 563 PHARQ-EMQTPRTRPRLSAGVAEV---IVLVGGRQMVGMTQ--RSLVAVTCWNPQNNKWY 616
           PH  +  M  P  + R   GVA     +  VGG          R L  V  ++P+ + W 
Sbjct: 622 PHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWT 681

Query: 617 PLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPR 673
            +A L    R+   V   GD +Y  GG +    L  +  Y    + W  ++ + + R
Sbjct: 682 MVAPLSM-PRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGR 737



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 30/123 (24%), Positives = 52/123 (42%), Gaps = 14/123 (11%)

Query: 577 RLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVS 633
           R + GVA +   +  VGGR         L ++  ++P  NKW   A +    R    V +
Sbjct: 590 RSTVGVAALNGKLYSVGGRD----GSSCLSSMEYYDPHTNKWNMCAPM-CKRRGGVGVAT 644

Query: 634 AGDNIYLSGGMESGVT------LADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYT 687
               +Y  GG ++  +      L  V  Y    D W +V+ +++PR      +   ++Y 
Sbjct: 645 CDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYA 704

Query: 688 LGG 690
           +GG
Sbjct: 705 VGG 707


>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
          Length = 694

 Score =  171 bits (434), Expect = 2e-42
 Identities = 103/357 (28%), Positives = 182/357 (50%), Gaps = 13/357 (3%)

Query: 346 VLASCSLYFKDLIQRSVQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAK 405
           VL+S S YF  +    V+++ Q      E+ +  ++ + L  L+++ YTG L +   N +
Sbjct: 176 VLSSVSDYFAAMFTNDVREARQE-----EIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 230

Query: 406 TLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPE 465
            LL  A   Q     + C  FL KQL  SNCLG+ + A+A  C++L+ +A  + ++ F E
Sbjct: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFME 290

Query: 466 VAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRL 525
           V   +E + +   +    +++D +N   EE +   ++ W++ D   R +  ++LLA +RL
Sbjct: 291 VIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 350

Query: 526 PFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEV 585
           P + P +L + ++N  L +    C+ L+ EA +YH+LP  R  +Q+PRT+PR S      
Sbjct: 351 PLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS--TVGT 407

Query: 586 IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME 645
           +  VGG      + +   ++  ++ + N W P+A++    R  F V    D +Y+ GG +
Sbjct: 408 LFAVGGMD----STKGATSIEKYDLRTNMWTPVANMN-GRRLQFGVAVLDDKLYVVGGRD 462

Query: 646 SGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
              TL  V CY      W+++  M+  R      V +G +Y +GG      ++ VER
Sbjct: 463 GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVER 519



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 33/121 (27%), Positives = 50/121 (41%), Gaps = 6/121 (4%)

Query: 572 PRTRPRLSAGVAEVIVLVGGRQMVGMTQ--RSLVAVTCWNPQNNKWYPLASLPFYDREFF 629
           P +  R   GVA   VL G    VG       L  V  W+PQ  +W  +A++    R   
Sbjct: 485 PMSTHRHGLGVA---VLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMST-PRSTV 540

Query: 630 SVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLG 689
            V      +Y  GG +    L  V C+    + W L ++M+  R       ++G +Y +G
Sbjct: 541 GVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG 600

Query: 690 G 690
           G
Sbjct: 601 G 601



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 15/149 (10%)

Query: 563 PHARQ-EMQTPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
           P ARQ       + PR + GVA +   +  VGGR         L +V C++P  NKW   
Sbjct: 522 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD----GSSCLKSVECFDPHTNKWTLC 577

Query: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVT-----LAD-VWCYMSLLDNWNLVSRMTVP 672
           A +    R    V +    +Y  GG ++  +     L+D V  Y    D W  V+ M++ 
Sbjct: 578 AQMS-KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSIS 636

Query: 673 RCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
           R      +   K+Y +GG      ++ VE
Sbjct: 637 RDAVGVCLLGDKLYAVGGYDGQAYLNTVE 665



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 20/77 (25%), Positives = 34/77 (44%), Gaps = 1/77 (1%)

Query: 597 MTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCY 656
           +T R    V  ++P+ + W  +AS+    R+   V   GD +Y  GG +    L  V  Y
Sbjct: 609 LTSRLSDCVERYDPKTDMWTAVASMSI-SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 667

Query: 657 MSLLDNWNLVSRMTVPR 673
               + W  V+ + + R
Sbjct: 668 DPQTNEWTQVAPLCLGR 684


>gi|148664209 kelch-like 10 [Homo sapiens]
          Length = 608

 Score =  167 bits (423), Expect = 3e-41
 Identities = 110/388 (28%), Positives = 175/388 (45%), Gaps = 17/388 (4%)

Query: 320 NQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLSN 379
           N+ R      D+ I V G EF  H+N+L SCS YF+ L       SG    EK    +  
Sbjct: 30  NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFT-----SGWNNTEKKVYNIPG 84

Query: 380 LQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGV 439
           +  D+++L++E+ YT ++ I   N + LL AA +F      + C  FL+ +L   NC+G+
Sbjct: 85  ISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144

Query: 440 LAMAEAMQCSELYHMAKAFALQIFPE-VAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
               +   C EL   A  F L  F E V    E L +S  +    +  D LN K E+ V+
Sbjct: 145 CKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVF 204

Query: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
           E ++KWI  DP  R Q+ + LL  VRL  +H  Y +N V   + +K SE C+ ++  A +
Sbjct: 205 EAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK 264

Query: 559 ----YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNK 614
                +M   +  +   P TRPRL      ++  +GG      T     A+  ++ + ++
Sbjct: 265 AMYDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWSGGSPTN----AIEAYDARADR 317

Query: 615 WYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRC 674
           W  +       R +         +Y+ GG +S      V  +  +   W+ V+ M   RC
Sbjct: 318 WVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRC 377

Query: 675 RHNSLVYDGKIYTLGGLGVAGNVDHVER 702
             +  V    IY +GG      ++  ER
Sbjct: 378 YVSVTVLGNFIYAMGGFDGYVRLNTAER 405



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 21/89 (23%), Positives = 39/89 (43%), Gaps = 1/89 (1%)

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
           L     +N ++N+W  +A +    R    V++ G+++Y  GG +    L     Y  + +
Sbjct: 447 LFTAEVYNTESNQWTVIAPMRSR-RSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVAN 505

Query: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            W  +  M  PR      V D  ++ +GG
Sbjct: 506 TWRTIPTMFNPRSNFGIEVVDDLLFVVGG 534



 Score = 34.3 bits (77), Expect = 0.40
 Identities = 20/94 (21%), Positives = 37/94 (39%), Gaps = 1/94 (1%)

Query: 608 WNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVS 667
           + P+ N+W  +A +    R   S  +    +Y+ GG      L     Y +  + W +++
Sbjct: 406 YEPETNQWTLIAPM-HEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIA 464

Query: 668 RMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVE 701
            M   R     + Y   +Y +GG   A  +   E
Sbjct: 465 PMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAE 498



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 20/82 (24%), Positives = 34/82 (41%), Gaps = 1/82 (1%)

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
           L +   ++P  N W  + ++ F  R  F +    D +++ GG     T  +V CY    D
Sbjct: 494 LRSAEAYSPVANTWRTIPTM-FNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTD 552

Query: 662 NWNLVSRMTVPRCRHNSLVYDG 683
            W     M++ R   +  V  G
Sbjct: 553 EWYDAHDMSIYRSALSCCVVPG 574


>gi|128485503 kelch-like 30 [Homo sapiens]
          Length = 560

 Score =  164 bits (416), Expect = 2e-40
 Identities = 109/385 (28%), Positives = 183/385 (47%), Gaps = 28/385 (7%)

Query: 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLE 374
           ML  L + R      D+ ++V GRE   H+ +LA  S YF  +      +S     E   
Sbjct: 1   MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVE--- 57

Query: 375 LVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
             L +++  V+  L++FVYTG L I   N + L   A++  F +  KVC  +L++QL A+
Sbjct: 58  --LRDVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAA 115

Query: 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAE 494
           NCLG+    E      +   A AF  + F  VA ++E L + ++  +  ++ D L  + E
Sbjct: 116 NCLGICEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPE 175

Query: 495 ELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVN 554
           +   E +++W++ DP  R  +  ELL++V L  +    +  ++ +E LI+ SEACR  ++
Sbjct: 176 QSRLEALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALS 235

Query: 555 EAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMV-----GMTQRSLVAVTCWN 609
           +   +   P A Q+             + EV+V+VGG+ +            L     +N
Sbjct: 236 QG--HDGAPLALQQK------------LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYN 281

Query: 610 PQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVT----LADVWCYMSLLDNWNL 665
            +  +W  L   P Y +  FS+ +  +NIY++GG     T        WC+     +W  
Sbjct: 282 SKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKP 341

Query: 666 VSRMTVPRCRHNSLVYDGKIYTLGG 690
           V+ M  PR  H S   +G+IY +GG
Sbjct: 342 VAPMLKPRTNHASAALNGEIYVIGG 366



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 31/134 (23%), Positives = 54/134 (40%), Gaps = 14/134 (10%)

Query: 562 LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASL 621
           L  A  +   P  +PR +   A    L G   ++G T   +V V  ++P  + W P++  
Sbjct: 334 LKEASWKPVAPMLKPRTNHASA---ALNGEIYVIGGTTLDVVEVESYDPYTDSWTPVSPA 390

Query: 622 PFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSR------MTVPRCR 675
             Y   F S       +YL G          + CY  + D W++++       ++ PRC 
Sbjct: 391 LKYVSNF-SAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRC- 448

Query: 676 HNSLVYDGKIYTLG 689
                  G++Y +G
Sbjct: 449 ---AALHGELYLIG 459


>gi|40255071 kelch-like 23 [Homo sapiens]
          Length = 558

 Score =  162 bits (409), Expect = 1e-39
 Identities = 120/390 (30%), Positives = 176/390 (45%), Gaps = 27/390 (6%)

Query: 304 YEFTDPGHPREMLKELNQQRRAKAFTDLKIVV-EGREFEVHQNVLASCSLYFKDLIQRSV 362
           Y F D  HP + L           FTD+ +    G  F  H+ VLA+CS YFK +    +
Sbjct: 11  YLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADM 70

Query: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
           ++     + K ++ LS +  D+LE L+ + YT  + I   N ++LLEAA   QF +  K 
Sbjct: 71  KE-----KFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKA 125

Query: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
           C  FL + L   NC+G+ + AE   C EL   ++      F EV  QEE L IS + F+ 
Sbjct: 126 CERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLF 185

Query: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
            +S  +L+   EE + E VIKW   D   R +    LL+ + +  I P YL      +  
Sbjct: 186 ILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYL------KTA 238

Query: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSL 602
           +    +C  L+ E K   ++ +A   M        +S      + ++GG          L
Sbjct: 239 LGLQRSC--LLTENKIRSLIYNALNPM-----HKEISQRSTATMYIIGGYYW-----HPL 286

Query: 603 VAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESG--VTLADVWCYMSLL 660
             V  W+P  N W   A +P Y RE + V   G NIY++GG  +     L  VW Y S  
Sbjct: 287 SEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSES 346

Query: 661 DNWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
           D W     M   R  H ++   G +Y LGG
Sbjct: 347 DEWTEGLPMLNARYYHCAVTLGGCVYALGG 376



 Score = 33.1 bits (74), Expect = 0.90
 Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 4/86 (4%)

Query: 608 WNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGG---MESGVTLADVWCYMSLLDNWN 664
           ++P   KW P+A++        + V   D IY+ GG        T   V  Y S ++ W+
Sbjct: 389 YDPLKEKWIPIANMIKGVGNATACV-LHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWS 447

Query: 665 LVSRMTVPRCRHNSLVYDGKIYTLGG 690
           L++    P     S+ ++ K+Y +GG
Sbjct: 448 LITSSPHPEYGLCSVPFENKLYLVGG 473



 Score = 30.8 bits (68), Expect = 4.5
 Identities = 23/86 (26%), Positives = 38/86 (44%), Gaps = 6/86 (6%)

Query: 605 VTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWN 664
           V  +N   N+W  + S P  +    SV    + +YL GG     T+ +  CY    + W 
Sbjct: 436 VQSYNSDINEWSLITSSPHPEYGLCSVPFE-NKLYLVGGQ---TTITE--CYDPEQNEWR 489

Query: 665 LVSRMTVPRCRHNSLVYDGKIYTLGG 690
            ++ M   R    +++ +G IY  GG
Sbjct: 490 EIAPMMERRMECGAVIMNGCIYVTGG 515


>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
          Length = 720

 Score =  161 bits (408), Expect = 2e-39
 Identities = 103/392 (26%), Positives = 185/392 (47%), Gaps = 13/392 (3%)

Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
           H  + L+++    + K   D+ ++        H+ VL++ S YF  +    V ++ Q   
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQE-- 221

Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
              E+ +  +  + L  L+++ YTG L +     ++LL AA   Q      VC +FL KQ
Sbjct: 222 ---EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQ 278

Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
           L  SNCLG+ +  +A  C+EL ++A  + ++ F EV   +E L +  ++    + +D +N
Sbjct: 279 LHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDIN 338

Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
              EE ++  +++W+  D   R      LL+ +RLP + P  LL  ++   +      C+
Sbjct: 339 VPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLL-PPQLLADLETSSMFTGDLECQ 397

Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
            L+ EA +YH+LP  R  MQ+PRT+PR S      +  VGG        +    +  ++ 
Sbjct: 398 KLLMEAMKYHLLPERRSMMQSPRTKPRKS--TVGALYAVGGMD----AMKGTTTIEKYDL 451

Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
           + N W  + ++    R  F V    + +Y+ GG +   TL  V C+  +   W ++  M+
Sbjct: 452 RTNSWLHIGTMN-GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMS 510

Query: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
             R        +G +Y +GG      ++ VER
Sbjct: 511 THRHGLGVATLEGPMYAVGGHDGWSYLNTVER 542



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 1/89 (1%)

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
           L  V  W+P+  +W  +AS+    R    VV+  + +Y  GG +    L  +  +    +
Sbjct: 537 LNTVERWDPEGRQWNYVASMST-PRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTN 595

Query: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            W+L + M+  R       Y+G +Y +GG
Sbjct: 596 KWSLCAPMSKRRGGVGVATYNGFLYVVGG 624



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 27/107 (25%), Positives = 47/107 (43%), Gaps = 7/107 (6%)

Query: 563 PHARQ-EMQTPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVA--VTCWNPQNNKWY 616
           PH  +  +  P ++ R   GVA     + +VGG         S ++  V  ++P+ + W 
Sbjct: 592 PHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWS 651

Query: 617 PLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNW 663
            +A L    R+  +V   GD +Y+ GG +    L  V  Y +  + W
Sbjct: 652 TVAPLSV-PRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697


>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
          Length = 718

 Score =  161 bits (408), Expect = 2e-39
 Identities = 103/392 (26%), Positives = 185/392 (47%), Gaps = 13/392 (3%)

Query: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
           H  + L+++    + K   D+ ++        H+ VL++ S YF  +    V ++ Q   
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQE-- 221

Query: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
              E+ +  +  + L  L+++ YTG L +     ++LL AA   Q      VC +FL KQ
Sbjct: 222 ---EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQ 278

Query: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
           L  SNCLG+ +  +A  C+EL ++A  + ++ F EV   +E L +  ++    + +D +N
Sbjct: 279 LHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDIN 338

Query: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
              EE ++  +++W+  D   R      LL+ +RLP + P  LL  ++   +      C+
Sbjct: 339 VPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLL-PPQLLADLETSSMFTGDLECQ 397

Query: 551 DLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNP 610
            L+ EA +YH+LP  R  MQ+PRT+PR S      +  VGG        +    +  ++ 
Sbjct: 398 KLLMEAMKYHLLPERRSMMQSPRTKPRKS--TVGALYAVGGMD----AMKGTTTIEKYDL 451

Query: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
           + N W  + ++    R  F V    + +Y+ GG +   TL  V C+  +   W ++  M+
Sbjct: 452 RTNSWLHIGTMN-GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMS 510

Query: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVER 702
             R        +G +Y +GG      ++ VER
Sbjct: 511 THRHGLGVATLEGPMYAVGGHDGWSYLNTVER 542



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 1/89 (1%)

Query: 602 LVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLD 661
           L  V  W+P+  +W  +AS+    R    VV+  + +Y  GG +    L  +  +    +
Sbjct: 537 LNTVERWDPEGRQWNYVASMST-PRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTN 595

Query: 662 NWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            W+L + M+  R       Y+G +Y +GG
Sbjct: 596 KWSLCAPMSKRRGGVGVATYNGFLYVVGG 624



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 27/107 (25%), Positives = 47/107 (43%), Gaps = 7/107 (6%)

Query: 563 PHARQ-EMQTPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVA--VTCWNPQNNKWY 616
           PH  +  +  P ++ R   GVA     + +VGG         S ++  V  ++P+ + W 
Sbjct: 592 PHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWS 651

Query: 617 PLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNW 663
            +A L    R+  +V   GD +Y+ GG +    L  V  Y +  + W
Sbjct: 652 TVAPLSV-PRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697


>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
           sapiens]
          Length = 634

 Score =  159 bits (403), Expect = 6e-39
 Identities = 113/441 (25%), Positives = 198/441 (44%), Gaps = 71/441 (16%)

Query: 305 EFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQR--SV 362
           E TD  +   +L+ L++ R+     DL I  + + F+VH++V+ASCS YF +++++  S+
Sbjct: 49  ELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSI 108

Query: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
           Q           + L+++    L  ++ + YTG L +      +++ AA   Q HT  K+
Sbjct: 109 Q----------RVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKM 158

Query: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
           C  FL ++++  NC+ V+ +AE          A+ F    F E A  ++ + ++ +    
Sbjct: 159 CSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINE 218

Query: 483 YVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEEL 542
            + +D L   +E + ++  +KW++ D   R +YAA+LL+ +R   I    L+N V +   
Sbjct: 219 LLIDDDLQLPSEIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPR 277

Query: 543 IKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSL 602
           +     C  L+ +A  YH+LP+ +  +Q+ RTR R   G   V+V VGGR   G+T++SL
Sbjct: 278 MMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIR---GGCRVLVTVGGRP--GLTEKSL 332

Query: 603 VAVTCWNPQNNKWYPLASLPF--------------------------------------Y 624
                +    N W  L  +P                                       Y
Sbjct: 333 SRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRY 392

Query: 625 DREF---------------FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRM 669
           D  F               FS+      +Y +GG  +  +LA + CY+   + W   + +
Sbjct: 393 DPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPL 452

Query: 670 TVPRCRHNSLVYDGKIYTLGG 690
            V RC H S V DG++   GG
Sbjct: 453 EVARCCHASAVADGRVLVTGG 473



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 5/106 (4%)

Query: 585 VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGM 644
           ++   GGR   G    SL ++ C+ P  N+W P   L        S V+ G  + ++GG 
Sbjct: 420 LVYAAGGRNAEG----SLASLECYVPSTNQWQPKTPLEVARCCHASAVADG-RVLVTGGY 474

Query: 645 ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
            +      V  Y    D+W  +  ++ PR  H ++    ++Y +GG
Sbjct: 475 IANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGG 520


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,422,466
Number of Sequences: 37866
Number of extensions: 1744205
Number of successful extensions: 19778
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 322
Number of HSP's successfully gapped in prelim test: 1015
Number of HSP's that attempted gapping in prelim test: 11586
Number of HSP's gapped (non-prelim): 6029
length of query: 702
length of database: 18,247,518
effective HSP length: 109
effective length of query: 593
effective length of database: 14,120,124
effective search space: 8373233532
effective search space used: 8373233532
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.