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Search of human proteins with 116235466
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116235466 solute carrier family 25, member 45 isoform b
[Homo sapiens]
(246 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116235466 solute carrier family 25, member 45 isoform b [Homo... 504 e-143
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 504 e-143
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 208 3e-54
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 166 1e-41
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 127 1e-29
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 103 2e-22
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 103 2e-22
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 102 2e-22
gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens] 101 7e-22
gi|13994341 solute carrier family 25 member 2 [Homo sapiens] 98 8e-21
gi|223468576 mitochondrial carrier protein-like [Homo sapiens] 86 3e-17
gi|157388991 solute carrier family 25, member 36 isoform b [Homo... 86 3e-17
gi|157388989 solute carrier family 25, member 36 isoform a [Homo... 86 3e-17
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 86 4e-17
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 84 9e-17
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 84 1e-16
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 83 3e-16
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 77 1e-14
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 77 1e-14
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 77 1e-14
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 75 7e-14
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 74 2e-13
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 74 2e-13
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 74 2e-13
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 74 2e-13
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 74 2e-13
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 74 2e-13
gi|21361114 solute carrier family 25 (mitochondrial carrier; oxo... 74 2e-13
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 72 3e-13
gi|82775373 solute carrier family 25, member 37 [Homo sapiens] 72 3e-13
>gi|116235466 solute carrier family 25, member 45 isoform b [Homo
sapiens]
Length = 246
Score = 504 bits (1298), Expect = e-143
Identities = 246/246 (100%), Positives = 246/246 (100%)
Query: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI 60
MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI
Sbjct: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI 60
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG
Sbjct: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 180
LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL
Sbjct: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 180
Query: 181 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 240
DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY
Sbjct: 181 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 240
Query: 241 LLRWWG 246
LLRWWG
Sbjct: 241 LLRWWG 246
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 504 bits (1298), Expect = e-143
Identities = 246/246 (100%), Positives = 246/246 (100%)
Query: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI 60
MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI
Sbjct: 43 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI 102
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG
Sbjct: 103 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 162
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 180
LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL
Sbjct: 163 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 222
Query: 181 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 240
DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY
Sbjct: 223 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
Query: 241 LLRWWG 246
LLRWWG
Sbjct: 283 LLRWWG 288
Score = 73.9 bits (180), Expect = 1e-13
Identities = 61/196 (31%), Positives = 82/196 (41%), Gaps = 24/196 (12%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F+AG G L PFD +KVRLQ QT Y+G V C I+R E G
Sbjct: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQT-----------TYRGIVDCMVKIYRHESLLG 54
Query: 121 LFRG----AWALTLRDTPTVGIYFITYEGLCRQYTPE--GQNPSSATVLVAGGFAGIASW 174
F+G ++ + ++ G+Y T L E Q PS + +AG G
Sbjct: 55 FFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQA 114
Query: 175 VAATPLDMIKSRMQ-------MDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARA 227
P D+IK R+Q G YQG + C S R+EG FRG + R
Sbjct: 115 YCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRD 174
Query: 228 FPVNAVTFLSYEYLLR 243
P + F++YE L R
Sbjct: 175 TPTVGIYFITYEGLCR 190
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 208 bits (530), Expect = 3e-54
Identities = 106/259 (40%), Positives = 159/259 (61%), Gaps = 21/259 (8%)
Query: 5 YRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAG 64
Y E + GF++G+S P+ ++++V+SV FG Y + L + + A+P I L+G
Sbjct: 44 YHRERVWGFYRGLSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTK-ADITLSG 102
Query: 65 CTGGFLQAYCLAPFDLIKVRLQNQTEPRAQ-------------------PGSPPPRYQGP 105
C G ++ + +P ++ KVRLQ QT+ + Q P P P+Y+GP
Sbjct: 103 CASGLVRVFLTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGP 162
Query: 106 VHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQN-PSSATVLV 164
+HC A++ REEG GL++G+ AL LRD + YF++Y LC +P G + P VLV
Sbjct: 163 LHCLATVAREEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLV 222
Query: 165 AGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINS 224
AGG AG+ +W ATP+D+IKSR+Q DG +R Y+G+L CMV+S+R+EG V F+G+ +N
Sbjct: 223 AGGCAGVLAWAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNC 282
Query: 225 ARAFPVNAVTFLSYEYLLR 243
RAFPVN V F++YE +LR
Sbjct: 283 CRAFPVNMVVFVAYEAVLR 301
Score = 60.8 bits (146), Expect = 1e-09
Identities = 53/215 (24%), Positives = 85/215 (39%), Gaps = 42/215 (19%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F+AG GG P D +KVR+Q + P+Y G HC + E G
Sbjct: 3 FVAGAIGGVCGVAVGYPLDTVKVRIQTE-----------PKYTGIWHCVRDTYHRERVWG 51
Query: 121 LFRG----AWALTLRDTPTVGIYFITYEGLCR-QYTPEGQNPSSATVLVAGGFAGIASWV 175
+RG ++L + + G Y +CR +Y P+ A + ++G +G+
Sbjct: 52 FYRGLSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVF 111
Query: 176 AATPLDMIKSRM----QMDGLRRRV----------------------YQGMLDCMVSSIR 209
+P ++ K R+ Q +RR+ Y+G L C+ + R
Sbjct: 112 LTSPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAR 171
Query: 210 QEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRW 244
+EGL ++G + R A FLSY L W
Sbjct: 172 EEGLCGLYKGSSALVLRDGHSFATYFLSYAVLCEW 206
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 166 bits (421), Expect = 1e-41
Identities = 97/243 (39%), Positives = 137/243 (56%), Gaps = 18/243 (7%)
Query: 4 IYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLA 63
I + ES+LG +KG+ P+ + +N+++FGV NTL L H S ++ FLA
Sbjct: 49 IIKQESVLGLYKGLGSPLMGLTFINALVFGVQGNTLRAL---GHD-------SPLNQFLA 98
Query: 64 GCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFR 123
G G +Q P +L K RLQ Q P Y+G + C A I+ EG RG+ R
Sbjct: 99 GAAAGAIQCVICCPMELAKTRLQ------LQDAGPARTYKGSLDCLAQIYGHEGLRGVNR 152
Query: 124 GAWALTLRDTPTVGIYFITYEGLCRQYTPE-GQNPSSATVLVAGGFAGIASWVAATPLDM 182
G + LR+TP+ G+YF+TY+ L R E G +L+AGG +GI SW++ P+D+
Sbjct: 153 GMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDV 212
Query: 183 IKSRMQMDGLRRRV-YQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
+KSR+Q DGLR Y+G+LDC+ S R EG VF RG+ RAFPVNA TF + +
Sbjct: 213 VKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFATVTVV 272
Query: 242 LRW 244
L +
Sbjct: 273 LTY 275
Score = 89.7 bits (221), Expect = 2e-18
Identities = 63/189 (33%), Positives = 90/189 (47%), Gaps = 16/189 (8%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
FLAGC GG PFD +KVRLQ Q+ + P+Y+G +HC SI ++E G
Sbjct: 5 FLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEK-------PQYRGTLHCFKSIIKQESVLG 57
Query: 121 LFRGAWALTLRDTPTVGIYFIT--YEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAAT 178
L++G +P +G+ FI G+ + S +AG AG V
Sbjct: 58 LYKGL------GSPLMGLTFINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVICC 111
Query: 179 PLDMIKSRMQM-DGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLS 237
P+++ K+R+Q+ D R Y+G LDC+ EGL RG+ R P V FL+
Sbjct: 112 PMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLT 171
Query: 238 YEYLLRWWG 246
Y+ L R G
Sbjct: 172 YDALTRALG 180
Score = 50.1 bits (118), Expect = 2e-06
Identities = 51/167 (30%), Positives = 65/167 (38%), Gaps = 15/167 (8%)
Query: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQER--RAQPPSYM 58
+ +IY HE L G +GM S + + FGVY T LT E R P
Sbjct: 138 LAQIYGHEGLRGVNRGM----VSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPK-- 191
Query: 59 HIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGP 118
+ LAG T G + P D++K RLQ A PRY+G + C +R EG
Sbjct: 192 -LLLAGGTSGIVSWLSTYPVDVVKSRLQ------ADGLRGAPRYRGILDCVHQSYRAEGW 244
Query: 119 RGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVA 165
R RG + LR P F T + E P V A
Sbjct: 245 RVFTRGLASTLLRAFPVNAATFATVTVVLTYARGEEAGPEGEAVPAA 291
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 127 bits (318), Expect = 1e-29
Identities = 79/240 (32%), Positives = 118/240 (49%), Gaps = 15/240 (6%)
Query: 8 ESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTG 67
E + G ++GM+ PI + + +V F + L Q+ SY +F AG
Sbjct: 66 EGITGLYRGMAAPIIGVTPMFAVCFFGFG-----LGKKLQQKHPEDVLSYPQLFAAGMLS 120
Query: 68 GFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWA 127
G + P + IK LQ Q S +Y G + CA +++E G RG+++G
Sbjct: 121 GVFTTGIMTPGERIKCLLQ------IQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVL 174
Query: 128 LTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSAT---VLVAGGFAGIASWVAATPLDMIK 184
+RD P G+YF+TYE L +TPEG+ S + +LVAGG AGI +W A P D++K
Sbjct: 175 TLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLK 234
Query: 185 SRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRW 244
SR Q + G D + IR EG+ ++G RAFP NA FL +E +++
Sbjct: 235 SRFQ-TAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
Score = 77.0 bits (188), Expect = 1e-14
Identities = 60/193 (31%), Positives = 89/193 (46%), Gaps = 9/193 (4%)
Query: 53 QPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASI 112
+P S + LAG GG + P D +KVRLQ T+P + PG PP Y G C
Sbjct: 6 KPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQ--TQPPSLPGQPP-MYSGTFDCFRKT 62
Query: 113 FREEGPRGLFRGAWALTLRDTPTVGIYFITYEGL---CRQYTPEGQNPSSATVLVAGGFA 169
EG GL+RG A + TP + F + GL +Q PE S + AG +
Sbjct: 63 LFREGITGLYRGMAAPIIGVTPMFAVCFFGF-GLGKKLQQKHPE-DVLSYPQLFAAGMLS 120
Query: 170 GIASWVAATPLDMIKSRMQMDGLR-RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAF 228
G+ + TP + IK +Q+ Y G LDC ++ G+ ++G + R
Sbjct: 121 GVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDV 180
Query: 229 PVNAVTFLSYEYL 241
P + + F++YE+L
Sbjct: 181 PASGMYFMTYEWL 193
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 103 bits (256), Expect = 2e-22
Identities = 70/244 (28%), Positives = 110/244 (45%), Gaps = 17/244 (6%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
K+ R+E G ++G+ + +A ++ V + P I
Sbjct: 380 KVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVND-----FVRDKFMHKDGSVPLAAEILA 434
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
GC GG Q P +++K+RLQ E GP A S+ R+ G G++
Sbjct: 435 GGCAGGS-QVIFTNPLEIVKIRLQVAGEITT----------GPRVSALSVVRDLGFFGIY 483
Query: 123 RGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDM 182
+GA A LRD P IYF Y + + E S ++L+AG AG+ + TP D+
Sbjct: 484 KGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADV 543
Query: 183 IKSRMQMDG-LRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
IK+R+Q+ + Y G++DC +R+EG ++G R+ P VT L+YE L
Sbjct: 544 IKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELL 603
Query: 242 LRWW 245
RW+
Sbjct: 604 QRWF 607
Score = 62.4 bits (150), Expect = 3e-10
Identities = 47/181 (25%), Positives = 79/181 (43%), Gaps = 5/181 (2%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F G G + A + P DL+K R+QNQ + G Y+ C + R EG G
Sbjct: 332 FGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGE--LMYKNSFDCFKKVLRYEGFFG 389
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 180
L+RG L P I + + ++ + + A ++AGG AG + + PL
Sbjct: 390 LYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPL 449
Query: 181 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 240
+++K R+Q+ G + G +S +R G ++G R P +A+ F Y +
Sbjct: 450 EIVKIRLQVAG---EITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAH 506
Query: 241 L 241
+
Sbjct: 507 V 507
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 103 bits (256), Expect = 2e-22
Identities = 70/244 (28%), Positives = 110/244 (45%), Gaps = 17/244 (6%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
K+ R+E G ++G+ + +A ++ V + P I
Sbjct: 381 KVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVND-----FVRDKFMHKDGSVPLAAEILA 435
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
GC GG Q P +++K+RLQ E GP A S+ R+ G G++
Sbjct: 436 GGCAGGS-QVIFTNPLEIVKIRLQVAGEITT----------GPRVSALSVVRDLGFFGIY 484
Query: 123 RGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDM 182
+GA A LRD P IYF Y + + E S ++L+AG AG+ + TP D+
Sbjct: 485 KGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADV 544
Query: 183 IKSRMQMDG-LRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
IK+R+Q+ + Y G++DC +R+EG ++G R+ P VT L+YE L
Sbjct: 545 IKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELL 604
Query: 242 LRWW 245
RW+
Sbjct: 605 QRWF 608
Score = 62.4 bits (150), Expect = 3e-10
Identities = 47/181 (25%), Positives = 79/181 (43%), Gaps = 5/181 (2%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F G G + A + P DL+K R+QNQ + G Y+ C + R EG G
Sbjct: 333 FGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGE--LMYKNSFDCFKKVLRYEGFFG 390
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 180
L+RG L P I + + ++ + + A ++AGG AG + + PL
Sbjct: 391 LYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPL 450
Query: 181 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 240
+++K R+Q+ G + G +S +R G ++G R P +A+ F Y +
Sbjct: 451 EIVKIRLQVAG---EITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAH 507
Query: 241 L 241
+
Sbjct: 508 V 508
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 102 bits (255), Expect = 2e-22
Identities = 69/244 (28%), Positives = 107/244 (43%), Gaps = 17/244 (6%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
K+ R+E G ++G+ + +A ++ V R P +
Sbjct: 378 KVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVND-----FVRDKFTRRDGSVPLPAEVLA 432
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
GC GG Q P +++K+RLQ E GP A ++ R+ G GL+
Sbjct: 433 GGCAGGS-QVIFTNPLEIVKIRLQVAGEITT----------GPRVSALNVLRDLGIFGLY 481
Query: 123 RGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDM 182
+GA A LRD P IYF Y E + +L AG AG+ + TP D+
Sbjct: 482 KGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADV 541
Query: 183 IKSRMQMDG-LRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
IK+R+Q+ + Y G++DC +R+EG F++G R+ P VT ++YE L
Sbjct: 542 IKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELL 601
Query: 242 LRWW 245
RW+
Sbjct: 602 QRWF 605
Score = 61.6 bits (148), Expect = 6e-10
Identities = 50/181 (27%), Positives = 81/181 (44%), Gaps = 7/181 (3%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F G G + A + P DL+K R+QNQ + G Y+ C + R EG G
Sbjct: 330 FTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGE--LMYKNSFDCFKKVLRYEGFFG 387
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYT-PEGQNPSSATVLVAGGFAGIASWVAATP 179
L+RG + P I + + ++T +G P A VL AGG AG + + P
Sbjct: 388 LYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVL-AGGCAGGSQVIFTNP 446
Query: 180 LDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 239
L+++K R+Q+ G + G ++ +R G+ ++G R P +A+ F Y
Sbjct: 447 LEIVKIRLQVAG---EITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYA 503
Query: 240 Y 240
+
Sbjct: 504 H 504
Score = 35.8 bits (81), Expect = 0.035
Identities = 33/129 (25%), Positives = 48/129 (37%), Gaps = 16/129 (12%)
Query: 121 LFRGAWALTLRDTPTV-----GIYFITYEGLCRQYTPEGQNP------SSATVLVAGGFA 169
L+ + LTL D + G L RQ +P P SA G A
Sbjct: 277 LYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVA 336
Query: 170 GIASWVAATPLDMIKSRMQMDG-----LRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINS 224
G A P+D++K+RMQ + +Y+ DC +R EG +RG+
Sbjct: 337 GAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQL 396
Query: 225 ARAFPVNAV 233
P A+
Sbjct: 397 IGVAPEKAI 405
>gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
Length = 301
Score = 101 bits (251), Expect = 7e-22
Identities = 70/242 (28%), Positives = 111/242 (45%), Gaps = 7/242 (2%)
Query: 2 VKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIF 61
+K Y GF+KG S + + NSVLF Y V+ + +++A+ +
Sbjct: 52 LKTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNA- 110
Query: 62 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 121
AG A L P +L+K RLQ E G SI R++GP G
Sbjct: 111 AAGSFASAFAALVLCPTELVKCRLQTMYEMETS-GKIAKSQNTVWSVIKSILRKDGPLGF 169
Query: 122 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAAT 178
+ G + LR+ P +F YE L R + G++ ++++GG GI W+A
Sbjct: 170 YHGLSSTLLREVPGYFFFFGGYE-LSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVY 228
Query: 179 PLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSY 238
P+D IKSR+Q+ + + G + ++ ++ EG+ + G+ RAFP N FL+Y
Sbjct: 229 PVDCIKSRIQVLSMSGK-QAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAY 287
Query: 239 EY 240
EY
Sbjct: 288 EY 289
Score = 47.4 bits (111), Expect = 1e-05
Identities = 43/189 (22%), Positives = 72/189 (38%), Gaps = 23/189 (12%)
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
AG GG PFD +KV++Q P Y+G C + + G RG +
Sbjct: 15 AGAAGGTACVLTGQPFDTMKVKMQTF----------PDLYRGLTDCCLKTYSQVGFRGFY 64
Query: 123 RGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVL------VAGGFAGIASWVA 176
+G + + + F+ Y G C+Q + L AG FA + +
Sbjct: 65 KGTSPALIANIAENSVLFMCY-GFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALV 123
Query: 177 ATPLDMIKSR------MQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPV 230
P +++K R M+ G + + + S +R++G F+ G++ R P
Sbjct: 124 LCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPG 183
Query: 231 NAVTFLSYE 239
F YE
Sbjct: 184 YFFFFGGYE 192
Score = 38.5 bits (88), Expect = 0.005
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 5/87 (5%)
Query: 156 NPS--SATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGL 213
NP+ +A L AG G A + P D +K +MQ +Y+G+ DC + + Q G
Sbjct: 4 NPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFP---DLYRGLTDCCLKTYSQVGF 60
Query: 214 GVFFRGVTINSARAFPVNAVTFLSYEY 240
F++G + N+V F+ Y +
Sbjct: 61 RGFYKGTSPALIANIAENSVLFMCYGF 87
>gi|13994341 solute carrier family 25 member 2 [Homo sapiens]
Length = 301
Score = 97.8 bits (242), Expect = 8e-21
Identities = 67/242 (27%), Positives = 111/242 (45%), Gaps = 7/242 (2%)
Query: 2 VKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIF 61
+K Y L GF+KG + + NSVLF Y + + +++A+ S +
Sbjct: 52 LKTYAQVGLRGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKL-SDLQTA 110
Query: 62 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 121
AG A L P +L+K RLQ E G + I +++GP G
Sbjct: 111 AAGSFASAFAALALCPTELVKCRLQTMYEMEMS-GKIAKSHNTIWSVVKGILKKDGPLGF 169
Query: 122 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAAT 178
+ G + L++ P +F YE L R + G++ ++++GG AGI W+
Sbjct: 170 YHGLSSTLLQEVPGYFFFFGGYE-LSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVF 228
Query: 179 PLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSY 238
P+D IKSR+Q+ + + G + ++S +R EG+ + G+ RA P N F++Y
Sbjct: 229 PVDCIKSRIQVLSMYGK-QAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAY 287
Query: 239 EY 240
EY
Sbjct: 288 EY 289
Score = 50.4 bits (119), Expect = 1e-06
Identities = 43/189 (22%), Positives = 75/189 (39%), Gaps = 23/189 (12%)
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
AG GG PFD IKV++Q + P Y+G C + + G RG +
Sbjct: 15 AGAAGGTACVLTGQPFDTIKVKMQ----------TFPDLYKGLTDCFLKTYAQVGLRGFY 64
Query: 123 RGAWALTLRDTPTVGIYFITYEGLCRQYT------PEGQNPSSATVLVAGGFAGIASWVA 176
+G + + F+ Y G C+Q+ + S AG FA + +A
Sbjct: 65 KGTGPALMAYVAENSVLFMCY-GFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALA 123
Query: 177 ATPLDMIKSR------MQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPV 230
P +++K R M+M G + + + + ++++G F+ G++ + P
Sbjct: 124 LCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPG 183
Query: 231 NAVTFLSYE 239
F YE
Sbjct: 184 YFFFFGGYE 192
Score = 40.4 bits (93), Expect = 0.001
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 3/87 (3%)
Query: 154 GQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGL 213
G +A L AG G A + P D IK +MQ +Y+G+ DC + + Q GL
Sbjct: 4 GPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFP---DLYKGLTDCFLKTYAQVGL 60
Query: 214 GVFFRGVTINSARAFPVNAVTFLSYEY 240
F++G N+V F+ Y +
Sbjct: 61 RGFYKGTGPALMAYVAENSVLFMCYGF 87
>gi|223468576 mitochondrial carrier protein-like [Homo sapiens]
Length = 157
Score = 85.9 bits (211), Expect = 3e-17
Identities = 46/89 (51%), Positives = 57/89 (64%), Gaps = 1/89 (1%)
Query: 4 IYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPP-SYMHIFL 62
+YR ES+ GFFKGMSFP+ASIAV NSV+FGV+SNT L+ E A PP + + L
Sbjct: 49 VYRRESMFGFFKGMSFPLASIAVYNSVVFGVFSNTQRFLSQHRCGEPEASPPRTLSDLLL 108
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEP 91
A G + P DLIK+RLQ QT+P
Sbjct: 109 ASMVAGVVSVGLGGPVDLIKIRLQMQTQP 137
Score = 42.0 bits (97), Expect = 5e-04
Identities = 38/136 (27%), Positives = 59/136 (43%), Gaps = 18/136 (13%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F AG GG P D +K RLQ A G Y + C ++R E G
Sbjct: 9 FAAGWIGGAASVIVGHPLDTVKTRLQ------AGVG-----YGNTLSCIRVVYRRESMFG 57
Query: 121 LFRGAW----ALTLRDTPTVGIYFITYEGLCRQYT--PEGQNPSSAT-VLVAGGFAGIAS 173
F+G ++ + ++ G++ T L + PE P + + +L+A AG+ S
Sbjct: 58 FFKGMSFPLASIAVYNSVVFGVFSNTQRFLSQHRCGEPEASPPRTLSDLLLASMVAGVVS 117
Query: 174 WVAATPLDMIKSRMQM 189
P+D+IK R+QM
Sbjct: 118 VGLGGPVDLIKIRLQM 133
Score = 36.6 bits (83), Expect = 0.021
Identities = 24/71 (33%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 165 AGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINS 224
AG G AS + PLD +K+R+Q G+ Y L C+ R+E + FF+G++
Sbjct: 11 AGWIGGAASVIVGHPLDTVKTRLQA-GVG---YGNTLSCIRVVYRRESMFGFFKGMSFPL 66
Query: 225 ARAFPVNAVTF 235
A N+V F
Sbjct: 67 ASIAVYNSVVF 77
>gi|157388991 solute carrier family 25, member 36 isoform b [Homo
sapiens]
Length = 310
Score = 85.9 bits (211), Expect = 3e-17
Identities = 58/200 (29%), Positives = 97/200 (48%), Gaps = 15/200 (7%)
Query: 52 AQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN--------QTEPRAQPGSPPPRY- 102
+Q + +H+F GC GG + A P +++K RLQ+ + + G+ R
Sbjct: 2 SQRDTLVHLFAGGC-GGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVV 60
Query: 103 -QGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSAT 161
GP+HC I +EGPR LFRG + P+ IYF Y C++ + +P S
Sbjct: 61 SPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSN-CKEKLNDVFDPDSTQ 119
Query: 162 V-LVAGGFAGIASWVAATPLDMIKSRMQMDGLRR-RVYQGMLDCMVSSIRQEGLGVFFRG 219
V +++ AG + A P+ +IK+R+Q+D R G +C+ + +GL F+RG
Sbjct: 120 VHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRG 179
Query: 220 VTINSARAFPVNAVTFLSYE 239
++ + A + F+ YE
Sbjct: 180 MSASYA-GISETVIHFVIYE 198
Score = 66.2 bits (160), Expect = 2e-11
Identities = 60/251 (23%), Positives = 103/251 (41%), Gaps = 28/251 (11%)
Query: 4 IYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLA 63
I E F+G+ + +A ++ F YSN L P S ++
Sbjct: 71 ILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVF------DPDSTQVHMIS 124
Query: 64 GCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFR 123
GF P LIK RLQ R + R G C +++ +G +G +R
Sbjct: 125 AAMAGFTAITATNPIWLIKTRLQLDARNRGE------RRMGAFECVRKVYQTDGLKGFYR 178
Query: 124 GAWALTLRDTPTVGIYFITYEGLCRQY----TPEGQNPSSATVLVAGGFAGI-----ASW 174
G A + TV I+F+ YE + ++ T +V A F G+ S
Sbjct: 179 GMSASYAGISETV-IHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSK 237
Query: 175 VAATPL---DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVN 231
AT + ++++R++ +G + R + L +V ++EG G +RG+T + R P
Sbjct: 238 TCATTIAYPHVVRTRLREEGTKYRSFFQTLSLLV---QEEGYGSLYRGLTTHLVRQIPNT 294
Query: 232 AVTFLSYEYLL 242
A+ +YE ++
Sbjct: 295 AIMMATYELVV 305
Score = 41.6 bits (96), Expect = 6e-04
Identities = 36/148 (24%), Positives = 65/148 (43%), Gaps = 17/148 (11%)
Query: 3 KIYRHESLLGFFKGMSFPIASIA--VVNSVLFGVYSNTLL----VLTATSHQERRAQPPS 56
K+Y+ + L GF++GMS A I+ V++ V++ LL T + +E +
Sbjct: 166 KVYQTDGLKGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASD 225
Query: 57 YMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREE 116
++ + LA T A +A +++ RL+ + +Y+ + + +EE
Sbjct: 226 FVGMMLAAATSKTC-ATTIAYPHVVRTRLREE----------GTKYRSFFQTLSLLVQEE 274
Query: 117 GPRGLFRGAWALTLRDTPTVGIYFITYE 144
G L+RG +R P I TYE
Sbjct: 275 GYGSLYRGLTTHLVRQIPNTAIMMATYE 302
>gi|157388989 solute carrier family 25, member 36 isoform a [Homo
sapiens]
Length = 311
Score = 85.9 bits (211), Expect = 3e-17
Identities = 58/200 (29%), Positives = 97/200 (48%), Gaps = 15/200 (7%)
Query: 52 AQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN--------QTEPRAQPGSPPPRY- 102
+Q + +H+F GC GG + A P +++K RLQ+ + + G+ R
Sbjct: 2 SQRDTLVHLFAGGC-GGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVV 60
Query: 103 -QGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSAT 161
GP+HC I +EGPR LFRG + P+ IYF Y C++ + +P S
Sbjct: 61 SPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSN-CKEKLNDVFDPDSTQ 119
Query: 162 V-LVAGGFAGIASWVAATPLDMIKSRMQMDGLRR-RVYQGMLDCMVSSIRQEGLGVFFRG 219
V +++ AG + A P+ +IK+R+Q+D R G +C+ + +GL F+RG
Sbjct: 120 VHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRG 179
Query: 220 VTINSARAFPVNAVTFLSYE 239
++ + A + F+ YE
Sbjct: 180 MSASYA-GISETVIHFVIYE 198
Score = 68.6 bits (166), Expect = 5e-12
Identities = 60/252 (23%), Positives = 103/252 (40%), Gaps = 29/252 (11%)
Query: 4 IYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLA 63
I E F+G+ + +A ++ F YSN L P S ++
Sbjct: 71 ILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVF------DPDSTQVHMIS 124
Query: 64 GCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFR 123
GF P LIK RLQ R + R G C +++ +G +G +R
Sbjct: 125 AAMAGFTAITATNPIWLIKTRLQLDARNRGE------RRMGAFECVRKVYQTDGLKGFYR 178
Query: 124 GAWALTLRDTPTVGIYFITYEGLCRQY----TPEGQNPSSATVLVAGGFAGIASWVA--- 176
G A + TV I+F+ YE + ++ T +V A F G+ A
Sbjct: 179 GMSASYAGISETV-IHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSK 237
Query: 177 ------ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPV 230
A P +++++R++ +G + R + L +V ++EG G +RG+T + R P
Sbjct: 238 TCATTIAYPHEVVRTRLREEGTKYRSFFQTLSLLV---QEEGYGSLYRGLTTHLVRQIPN 294
Query: 231 NAVTFLSYEYLL 242
A+ +YE ++
Sbjct: 295 TAIMMATYELVV 306
Score = 47.0 bits (110), Expect = 2e-05
Identities = 35/148 (23%), Positives = 64/148 (43%), Gaps = 16/148 (10%)
Query: 3 KIYRHESLLGFFKGMSFPIASIA--VVNSVLFGVYSNTLL----VLTATSHQERRAQPPS 56
K+Y+ + L GF++GMS A I+ V++ V++ LL T + +E +
Sbjct: 166 KVYQTDGLKGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASD 225
Query: 57 YMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREE 116
++ + LA T P ++++ RL+ + +Y+ + + +EE
Sbjct: 226 FVGMMLAAATSKTCATTIAYPHEVVRTRLREE----------GTKYRSFFQTLSLLVQEE 275
Query: 117 GPRGLFRGAWALTLRDTPTVGIYFITYE 144
G L+RG +R P I TYE
Sbjct: 276 GYGSLYRGLTTHLVRQIPNTAIMMATYE 303
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 85.5 bits (210), Expect = 4e-17
Identities = 67/242 (27%), Positives = 108/242 (44%), Gaps = 19/242 (7%)
Query: 6 RHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGC 65
R +LG ++G+S + +V FG++ ++H L G
Sbjct: 76 RSHGVLGLYRGLSSLLYGSIPKAAVRFGMFE------FLSNHMRDAQGRLDSTRGLLCGL 129
Query: 66 TGGFLQAYCLA-PFDLIKVR-LQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFR 123
G +A + P + IKV+ + +QT SP P+Y+G H I RE+G +G ++
Sbjct: 130 GAGVAEAVVVVCPMETIKVKFIHDQT-------SPNPKYRGFFHGVREIVREQGLKGTYQ 182
Query: 124 GAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVL--VAGGFAGIASWVAATPLD 181
G A L+ I F L Y + N ++ V G AG AS TPLD
Sbjct: 183 GLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLD 242
Query: 182 MIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
+IK+RMQ GL Y+ DC + +++EGL F++G R A+ F+ Y+ +
Sbjct: 243 VIKTRMQ--GLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEV 300
Query: 242 LR 243
++
Sbjct: 301 VK 302
Score = 57.4 bits (137), Expect = 1e-08
Identities = 48/186 (25%), Positives = 75/186 (40%), Gaps = 8/186 (4%)
Query: 62 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 121
LAG G ++ P + +K +LQ S PPRY+G C R G GL
Sbjct: 30 LAGGLAGGIEICITFPTEYVKTQLQLDER------SHPPRYRGIGDCVRQTVRSHGVLGL 83
Query: 122 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIA-SWVAATPL 180
+RG +L P + F +E L S L+ G AG+A + V P+
Sbjct: 84 YRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPM 143
Query: 181 DMIKSRMQMDGLR-RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 239
+ IK + D Y+G + +R++GL ++G+T + A+ F
Sbjct: 144 ETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMT 203
Query: 240 YLLRWW 245
L W+
Sbjct: 204 SLRNWY 209
Score = 40.4 bits (93), Expect = 0.001
Identities = 23/80 (28%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRV-YQGMLDCMVSSIRQEGLGVFFRGVT 221
++AGG AG P + +K+++Q+D Y+G+ DC+ ++R G+ +RG++
Sbjct: 29 ILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLS 88
Query: 222 INSARAFPVNAVTFLSYEYL 241
+ P AV F +E+L
Sbjct: 89 SLLYGSIPKAAVRFGMFEFL 108
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 84.3 bits (207), Expect = 9e-17
Identities = 74/249 (29%), Positives = 111/249 (44%), Gaps = 24/249 (9%)
Query: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI 60
++K+ R ESLLG +KGMS I + V V G+Y TL L R PP+ +
Sbjct: 74 LLKVVRTESLLGLWKGMSPSI--VRCVPGV--GIYFGTLYSL---KQYFLRGHPPTALES 126
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
+ G + C++P +IK R + S Y+ SI+ EG RG
Sbjct: 127 VMLGVGSRSVAGVCMSPITVIKTRYE----------SGKYGYESIYAALRSIYHSEGHRG 176
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAA 177
LF G A LRD P GIY + Y + P Q ++ T G FAGI + +
Sbjct: 177 LFSGLTATLLRDAPFSGIYLMFY-NQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVT 235
Query: 178 TPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLS 237
P D+IK+ MQ+ L+ +Q + + + GL FF+G + R + A+ +
Sbjct: 236 QPADVIKTHMQLYPLK---FQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTV 292
Query: 238 YEYLLRWWG 246
YE ++ G
Sbjct: 293 YEEMMAKMG 301
Score = 62.0 bits (149), Expect = 5e-10
Identities = 49/178 (27%), Positives = 75/178 (42%), Gaps = 9/178 (5%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
FL G G P DL+K RLQ QP R G + + R E G
Sbjct: 31 FLCGSISGTCSTLLFQPLDLLKTRLQT-----LQPSDHGSRRVGMLAVLLKVVRTESLLG 85
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 180
L++G +R P VGIYF T L +QY G P++ ++ G + + V +P+
Sbjct: 86 LWKGMSPSIVRCVPGVGIYFGTLYSL-KQYFLRGHPPTALESVMLGVGSRSVAGVCMSPI 144
Query: 181 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSY 238
+IK+R + + Y+ + + S EG F G+T R P + + + Y
Sbjct: 145 TVIKTRYESG---KYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLMFY 199
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 84.0 bits (206), Expect = 1e-16
Identities = 64/216 (29%), Positives = 96/216 (44%), Gaps = 10/216 (4%)
Query: 29 SVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQ 88
S+ G+Y + V T + A S LAGCT G + C P D++KVR Q
Sbjct: 93 SIRIGLYDSVKQVYTP-----KGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQAS 147
Query: 89 TEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCR 148
P +Y G + +I REEG RGL++G +R+ +TY+ L
Sbjct: 148 IH--LGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKE 205
Query: 149 QYTPEGQNPSSATVLVAGGF-AGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSS 207
+ + F AG + V A+P+D++K+R + Y LDCM+
Sbjct: 206 KLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQ--YFSPLDCMIKM 263
Query: 208 IRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLR 243
+ QEG F++G T + R N V F++YE L R
Sbjct: 264 VAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKR 299
Score = 72.4 bits (176), Expect = 3e-13
Identities = 58/194 (29%), Positives = 86/194 (44%), Gaps = 6/194 (3%)
Query: 54 PPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIF 113
PP+ FL T P D KVRLQ Q E +A + +Y+G + ++
Sbjct: 10 PPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMV 69
Query: 114 REEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATV-LVAGGFAGIA 172
R EGP + G A R I Y+ + + YTP+G + SS T ++AG G
Sbjct: 70 RTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAM 129
Query: 173 SWVAATPLDMIKSRMQMD---GLRR--RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARA 227
+ A P D++K R Q G R R Y G +D + R+EG+ ++G N R
Sbjct: 130 AVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRN 189
Query: 228 FPVNAVTFLSYEYL 241
VN ++Y+ L
Sbjct: 190 AIVNCAEVVTYDIL 203
Score = 31.6 bits (70), Expect = 0.66
Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 7/68 (10%)
Query: 152 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRV-------YQGMLDCM 204
P P+ A + G A + + PLD K R+Q+ G + V Y+G+L +
Sbjct: 6 PSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTI 65
Query: 205 VSSIRQEG 212
++ +R EG
Sbjct: 66 LTMVRTEG 73
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 82.8 bits (203), Expect = 3e-16
Identities = 71/264 (26%), Positives = 107/264 (40%), Gaps = 36/264 (13%)
Query: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATS---HQ-ERRAQPPS 56
++K R E G ++G A VN L V + L A HQ + Q +
Sbjct: 53 LIKTVRSEGYFGMYRG--------AAVNLTL--VTPEKAIKLAANDFFRHQLSKDGQKLT 102
Query: 57 YMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQ------------PGSPPPRYQG 104
+ LAGC G Q P +++K++LQ+ AQ G P +
Sbjct: 103 LLKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEA 162
Query: 105 PV-------HCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNP 157
P + R G GL++G A LRD P +YF + L + P +
Sbjct: 163 PAAPRPTATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEK 222
Query: 158 SSATV-LVAGGFAGIASWVAATPLDMIKSRMQ--MDGLRRRVYQGMLDCMVSSIRQEGLG 214
S V +AG AG A+ VA P D++K+R+Q G+ Y G+LDC +R EG
Sbjct: 223 SPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPS 282
Query: 215 VFFRGVTINSARAFPVNAVTFLSY 238
F +G + P+ + + Y
Sbjct: 283 AFLKGAYCRALVIAPLFGIAQVVY 306
Score = 55.1 bits (131), Expect = 6e-08
Identities = 24/78 (30%), Positives = 41/78 (52%)
Query: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 222
L+ GG AG+ P+D+ K+R+Q +RVY M DC++ ++R EG +RG +
Sbjct: 12 LINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAV 71
Query: 223 NSARAFPVNAVTFLSYEY 240
N P A+ + ++
Sbjct: 72 NLTLVTPEKAIKLAANDF 89
Score = 54.7 bits (130), Expect = 7e-08
Identities = 37/128 (28%), Positives = 54/128 (42%), Gaps = 7/128 (5%)
Query: 64 GCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFR 123
G G + C+ P DL K RLQNQ + Y C R EG G++R
Sbjct: 15 GGIAGLIGVTCVFPIDLAKTRLQNQQNGQRV-------YTSMSDCLIKTVRSEGYFGMYR 67
Query: 124 GAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMI 183
GA TP I + Q + +GQ + ++AG AG + TP++M+
Sbjct: 68 GAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIVTTPMEML 127
Query: 184 KSRMQMDG 191
K ++Q G
Sbjct: 128 KIQLQDAG 135
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 77.4 bits (189), Expect = 1e-14
Identities = 50/192 (26%), Positives = 84/192 (43%), Gaps = 20/192 (10%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F+ G + + P D+++ R Q EP+ Y H +++R EGP+
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKV--------YNTLRHAVGTMYRSEGPQV 173
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYT----PEGQNPSSATVLVAGGFAGIASWVA 176
++G + P G+ F Y L Y EG+ + L+ G AG+ S
Sbjct: 174 FYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTL 233
Query: 177 ATPLDMIKSRMQMDGLRR--------RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAF 228
PLD+ K R+Q+ G R Y+G++DC +++EG FF+G++ + +A
Sbjct: 234 TYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAA 293
Query: 229 PVNAVTFLSYEY 240
F SYE+
Sbjct: 294 LSTGFMFFSYEF 305
Score = 70.1 bits (170), Expect = 2e-12
Identities = 47/191 (24%), Positives = 87/191 (45%), Gaps = 9/191 (4%)
Query: 60 IFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPR 119
+ +AG G + ++PFD+IK+R Q Q E R P +Y G + + I +EEGP
Sbjct: 18 VAVAGSVSGLVTRALISPFDVIKIRFQLQHE-RLSRSDPSAKYHGILQASRQILQEEGPT 76
Query: 120 GLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVA 176
++G + + F+++E + + G + + V GG A + +
Sbjct: 77 AFWKGHVPAQILSIGYGAVQFLSFE-MLTELVHRGSVYDAREFSVHFVCGGLAACMATLT 135
Query: 177 ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFL 236
P+D++++R G +VY + + + R EG VF++G+ FP + F
Sbjct: 136 VHPVDVLRTRFAAQG-EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
Query: 237 SY---EYLLRW 244
Y ++L +W
Sbjct: 195 CYSSLKHLYKW 205
Score = 50.1 bits (118), Expect = 2e-06
Identities = 38/148 (25%), Positives = 61/148 (41%), Gaps = 3/148 (2%)
Query: 4 IYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLA 63
+YR E F+KG++ + +I + F YS+ + E + + L
Sbjct: 165 MYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN--ENLQNLLC 222
Query: 64 GCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPG-SPPPRYQGPVHCAASIFREEGPRGLF 122
G G + P DL K RLQ A+ RY+G + CA + ++EG G F
Sbjct: 223 GSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFF 282
Query: 123 RGAWALTLRDTPTVGIYFITYEGLCRQY 150
+G L+ + G F +YE C +
Sbjct: 283 KGLSPSLLKAALSTGFMFFSYEFFCNVF 310
Score = 46.6 bits (109), Expect = 2e-05
Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 152 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLR------RRVYQGMLDCMV 205
P+G+N + V VAG +G+ + +P D+IK R Q+ R Y G+L
Sbjct: 8 PDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
Query: 206 SSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
+++EG F++G + AV FLS+E L
Sbjct: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML 103
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 77.4 bits (189), Expect = 1e-14
Identities = 50/192 (26%), Positives = 84/192 (43%), Gaps = 20/192 (10%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F+ G + + P D+++ R Q EP+ Y H +++R EGP+
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKV--------YNTLRHAVGTMYRSEGPQV 173
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYT----PEGQNPSSATVLVAGGFAGIASWVA 176
++G + P G+ F Y L Y EG+ + L+ G AG+ S
Sbjct: 174 FYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTL 233
Query: 177 ATPLDMIKSRMQMDGLRR--------RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAF 228
PLD+ K R+Q+ G R Y+G++DC +++EG FF+G++ + +A
Sbjct: 234 TYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAA 293
Query: 229 PVNAVTFLSYEY 240
F SYE+
Sbjct: 294 LSTGFMFFSYEF 305
Score = 70.1 bits (170), Expect = 2e-12
Identities = 47/191 (24%), Positives = 87/191 (45%), Gaps = 9/191 (4%)
Query: 60 IFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPR 119
+ +AG G + ++PFD+IK+R Q Q E R P +Y G + + I +EEGP
Sbjct: 18 VAVAGSVSGLVTRALISPFDVIKIRFQLQHE-RLSRSDPSAKYHGILQASRQILQEEGPT 76
Query: 120 GLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVA 176
++G + + F+++E + + G + + V GG A + +
Sbjct: 77 AFWKGHVPAQILSIGYGAVQFLSFE-MLTELVHRGSVYDAREFSVHFVCGGLAACMATLT 135
Query: 177 ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFL 236
P+D++++R G +VY + + + R EG VF++G+ FP + F
Sbjct: 136 VHPVDVLRTRFAAQG-EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
Query: 237 SY---EYLLRW 244
Y ++L +W
Sbjct: 195 CYSSLKHLYKW 205
Score = 50.1 bits (118), Expect = 2e-06
Identities = 38/148 (25%), Positives = 61/148 (41%), Gaps = 3/148 (2%)
Query: 4 IYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLA 63
+YR E F+KG++ + +I + F YS+ + E + + L
Sbjct: 165 MYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN--ENLQNLLC 222
Query: 64 GCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPG-SPPPRYQGPVHCAASIFREEGPRGLF 122
G G + P DL K RLQ A+ RY+G + CA + ++EG G F
Sbjct: 223 GSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFF 282
Query: 123 RGAWALTLRDTPTVGIYFITYEGLCRQY 150
+G L+ + G F +YE C +
Sbjct: 283 KGLSPSLLKAALSTGFMFFSYEFFCNVF 310
Score = 46.6 bits (109), Expect = 2e-05
Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 152 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLR------RRVYQGMLDCMV 205
P+G+N + V VAG +G+ + +P D+IK R Q+ R Y G+L
Sbjct: 8 PDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
Query: 206 SSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
+++EG F++G + AV FLS+E L
Sbjct: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML 103
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 77.4 bits (189), Expect = 1e-14
Identities = 50/192 (26%), Positives = 84/192 (43%), Gaps = 20/192 (10%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F+ G + + P D+++ R Q EP+ Y H +++R EGP+
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKV--------YNTLRHAVGTMYRSEGPQV 173
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYT----PEGQNPSSATVLVAGGFAGIASWVA 176
++G + P G+ F Y L Y EG+ + L+ G AG+ S
Sbjct: 174 FYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTL 233
Query: 177 ATPLDMIKSRMQMDGLRR--------RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAF 228
PLD+ K R+Q+ G R Y+G++DC +++EG FF+G++ + +A
Sbjct: 234 TYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAA 293
Query: 229 PVNAVTFLSYEY 240
F SYE+
Sbjct: 294 LSTGFMFFSYEF 305
Score = 70.1 bits (170), Expect = 2e-12
Identities = 47/191 (24%), Positives = 87/191 (45%), Gaps = 9/191 (4%)
Query: 60 IFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPR 119
+ +AG G + ++PFD+IK+R Q Q E R P +Y G + + I +EEGP
Sbjct: 18 VAVAGSVSGLVTRALISPFDVIKIRFQLQHE-RLSRSDPSAKYHGILQASRQILQEEGPT 76
Query: 120 GLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVA 176
++G + + F+++E + + G + + V GG A + +
Sbjct: 77 AFWKGHVPAQILSIGYGAVQFLSFE-MLTELVHRGSVYDAREFSVHFVCGGLAACMATLT 135
Query: 177 ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFL 236
P+D++++R G +VY + + + R EG VF++G+ FP + F
Sbjct: 136 VHPVDVLRTRFAAQG-EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
Query: 237 SY---EYLLRW 244
Y ++L +W
Sbjct: 195 CYSSLKHLYKW 205
Score = 50.1 bits (118), Expect = 2e-06
Identities = 38/148 (25%), Positives = 61/148 (41%), Gaps = 3/148 (2%)
Query: 4 IYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLA 63
+YR E F+KG++ + +I + F YS+ + E + + L
Sbjct: 165 MYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN--ENLQNLLC 222
Query: 64 GCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPG-SPPPRYQGPVHCAASIFREEGPRGLF 122
G G + P DL K RLQ A+ RY+G + CA + ++EG G F
Sbjct: 223 GSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFF 282
Query: 123 RGAWALTLRDTPTVGIYFITYEGLCRQY 150
+G L+ + G F +YE C +
Sbjct: 283 KGLSPSLLKAALSTGFMFFSYEFFCNVF 310
Score = 46.6 bits (109), Expect = 2e-05
Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 152 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLR------RRVYQGMLDCMV 205
P+G+N + V VAG +G+ + +P D+IK R Q+ R Y G+L
Sbjct: 8 PDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
Query: 206 SSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
+++EG F++G + AV FLS+E L
Sbjct: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML 103
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 74.7 bits (182), Expect = 7e-14
Identities = 57/234 (24%), Positives = 99/234 (42%), Gaps = 26/234 (11%)
Query: 14 FKGMSFPIASIAVVNSVLFGVYSN---TLLVLTATSHQERRAQPPSYMHIFLAGCTGGFL 70
++G + IA +++ F Y +L T H + R F+AG G
Sbjct: 242 WRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQER---------FVAGSLAGAT 292
Query: 71 QAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTL 130
+ P +++K RL + + Y+G + CA I EGPR +RG L
Sbjct: 293 AQTIIYPMEVLKTRLTLRRTGQ---------YKGLLDCARRILEREGPRAFYRGYLPNVL 343
Query: 131 RDTPTVGIYFITYEGL----CRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSR 186
P GI YE L +QY+ + +P +L G + +A+ PL ++++R
Sbjct: 344 GIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTR 403
Query: 187 MQMD-GLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 239
MQ + ML + + QEG+ +RG+ N + P +++++ YE
Sbjct: 404 MQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYE 457
Score = 66.2 bits (160), Expect = 2e-11
Identities = 49/184 (26%), Positives = 76/184 (41%), Gaps = 10/184 (5%)
Query: 62 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 121
+AG G + AP D +KV +Q + + S+ E G R L
Sbjct: 190 VAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNI--------LGGLRSMVLEGGIRSL 241
Query: 122 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLD 181
+RG L+ P I F+ YE + R + + VAG AG + P++
Sbjct: 242 WRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGATAQTIIYPME 301
Query: 182 MIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
++K+R+ + R Y+G+LDC + +EG F+RG N P + YE L
Sbjct: 302 VLKTRLTLR--RTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETL 359
Query: 242 LRWW 245
WW
Sbjct: 360 KNWW 363
Score = 41.6 bits (96), Expect = 6e-04
Identities = 26/81 (32%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Query: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 222
LVAG AG S PLD +K MQ+ + +L + S + + G+ +RG I
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTN-RLNILGGLRSMVLEGGIRSLWRGNGI 247
Query: 223 NSARAFPVNAVTFLSYEYLLR 243
N + P +A+ F++YE + R
Sbjct: 248 NVLKIAPESAIKFMAYEQIKR 268
Score = 32.3 bits (72), Expect = 0.39
Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 6/70 (8%)
Query: 77 PFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTV 136
P L++ R+Q Q G P G + I +EG RGL+RG ++ P V
Sbjct: 396 PLALVRTRMQAQASIE---GGPQLSMLGLLR---HILSQEGMRGLYRGIAPNFMKVIPAV 449
Query: 137 GIYFITYEGL 146
I ++ YE +
Sbjct: 450 SISYVVYENM 459
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 73.6 bits (179), Expect = 2e-13
Identities = 61/218 (27%), Positives = 92/218 (42%), Gaps = 13/218 (5%)
Query: 28 NSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN 87
+S +F V N L V + +ER Q + +AG G + C AP D +KV +Q
Sbjct: 160 HSTIFDVGEN-LTVPDEFTVEER--QTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQV 216
Query: 88 QTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLC 147
G V + RE G R L+RG L+ P I F+ YE +
Sbjct: 217 HASRSNN--------MGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIK 268
Query: 148 RQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSS 207
R + + LVAG AG + + P++++K+RM + + Y GMLDC
Sbjct: 269 RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALR--KTGQYSGMLDCARRI 326
Query: 208 IRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWW 245
+ +EG+ F++G N P + YE L W
Sbjct: 327 LAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAW 364
Score = 47.8 bits (112), Expect = 9e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 222
LVAGG AG S PLD +K MQ+ R G++ IR+ G +RG I
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSN-NMGIVGGFTQMIREGGARSLWRGNGI 248
Query: 223 NSARAFPVNAVTFLSYEYLLRWWG 246
N + P +A+ F++YE + R G
Sbjct: 249 NVLKIAPESAIKFMAYEQIKRLVG 272
Score = 33.5 bits (75), Expect = 0.17
Identities = 33/144 (22%), Positives = 49/144 (34%), Gaps = 8/144 (5%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
+I E + F+KG + I + VY L H + P +
Sbjct: 325 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET--LKNAWLQHYAVNSADPGVFVLLA 382
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
G P L++ R+Q Q G+P I R EG GL+
Sbjct: 383 CGTMSSTCGQLASYPLALVRTRMQAQASIE---GAPEVTMSS---LFKHILRTEGAFGLY 436
Query: 123 RGAWALTLRDTPTVGIYFITYEGL 146
RG ++ P V I ++ YE L
Sbjct: 437 RGLAPNFMKVIPAVSISYVVYENL 460
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 73.6 bits (179), Expect = 2e-13
Identities = 61/218 (27%), Positives = 92/218 (42%), Gaps = 13/218 (5%)
Query: 28 NSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN 87
+S +F V N L V + +ER Q + +AG G + C AP D +KV +Q
Sbjct: 194 HSTIFDVGEN-LTVPDEFTVEER--QTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQV 250
Query: 88 QTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLC 147
G V + RE G R L+RG L+ P I F+ YE +
Sbjct: 251 HASRSNN--------MGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIK 302
Query: 148 RQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSS 207
R + + LVAG AG + + P++++K+RM + + Y GMLDC
Sbjct: 303 RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALR--KTGQYSGMLDCARRI 360
Query: 208 IRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWW 245
+ +EG+ F++G N P + YE L W
Sbjct: 361 LAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAW 398
Score = 47.8 bits (112), Expect = 9e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 222
LVAGG AG S PLD +K MQ+ R G++ IR+ G +RG I
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSN-NMGIVGGFTQMIREGGARSLWRGNGI 282
Query: 223 NSARAFPVNAVTFLSYEYLLRWWG 246
N + P +A+ F++YE + R G
Sbjct: 283 NVLKIAPESAIKFMAYEQIKRLVG 306
Score = 33.5 bits (75), Expect = 0.17
Identities = 33/144 (22%), Positives = 49/144 (34%), Gaps = 8/144 (5%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
+I E + F+KG + I + VY L H + P +
Sbjct: 359 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET--LKNAWLQHYAVNSADPGVFVLLA 416
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
G P L++ R+Q Q G+P I R EG GL+
Sbjct: 417 CGTMSSTCGQLASYPLALVRTRMQAQASIE---GAPEVTMSS---LFKHILRTEGAFGLY 470
Query: 123 RGAWALTLRDTPTVGIYFITYEGL 146
RG ++ P V I ++ YE L
Sbjct: 471 RGLAPNFMKVIPAVSISYVVYENL 494
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 73.6 bits (179), Expect = 2e-13
Identities = 61/218 (27%), Positives = 92/218 (42%), Gaps = 13/218 (5%)
Query: 28 NSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN 87
+S +F V N L V + +ER Q + +AG G + C AP D +KV +Q
Sbjct: 180 HSTIFDVGEN-LTVPDEFTVEER--QTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQV 236
Query: 88 QTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLC 147
G V + RE G R L+RG L+ P I F+ YE +
Sbjct: 237 HASRSNN--------MGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIK 288
Query: 148 RQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSS 207
R + + LVAG AG + + P++++K+RM + + Y GMLDC
Sbjct: 289 RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALR--KTGQYSGMLDCARRI 346
Query: 208 IRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWW 245
+ +EG+ F++G N P + YE L W
Sbjct: 347 LAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAW 384
Score = 47.8 bits (112), Expect = 9e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 222
LVAGG AG S PLD +K MQ+ R G++ IR+ G +RG I
Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSN-NMGIVGGFTQMIREGGARSLWRGNGI 268
Query: 223 NSARAFPVNAVTFLSYEYLLRWWG 246
N + P +A+ F++YE + R G
Sbjct: 269 NVLKIAPESAIKFMAYEQIKRLVG 292
Score = 33.5 bits (75), Expect = 0.17
Identities = 33/144 (22%), Positives = 49/144 (34%), Gaps = 8/144 (5%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
+I E + F+KG + I + VY L H + P +
Sbjct: 345 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET--LKNAWLQHYAVNSADPGVFVLLA 402
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
G P L++ R+Q Q G+P I R EG GL+
Sbjct: 403 CGTMSSTCGQLASYPLALVRTRMQAQASIE---GAPEVTMSS---LFKHILRTEGAFGLY 456
Query: 123 RGAWALTLRDTPTVGIYFITYEGL 146
RG ++ P V I ++ YE L
Sbjct: 457 RGLAPNFMKVIPAVSISYVVYENL 480
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 73.6 bits (179), Expect = 2e-13
Identities = 61/218 (27%), Positives = 92/218 (42%), Gaps = 13/218 (5%)
Query: 28 NSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN 87
+S +F V N L V + +ER Q + +AG G + C AP D +KV +Q
Sbjct: 160 HSTIFDVGEN-LTVPDEFTVEER--QTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQV 216
Query: 88 QTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLC 147
G V + RE G R L+RG L+ P I F+ YE +
Sbjct: 217 HASRSNN--------MGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIK 268
Query: 148 RQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSS 207
R + + LVAG AG + + P++++K+RM + + Y GMLDC
Sbjct: 269 RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALR--KTGQYSGMLDCARRI 326
Query: 208 IRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWW 245
+ +EG+ F++G N P + YE L W
Sbjct: 327 LAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAW 364
Score = 47.8 bits (112), Expect = 9e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 222
LVAGG AG S PLD +K MQ+ R G++ IR+ G +RG I
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSN-NMGIVGGFTQMIREGGARSLWRGNGI 248
Query: 223 NSARAFPVNAVTFLSYEYLLRWWG 246
N + P +A+ F++YE + R G
Sbjct: 249 NVLKIAPESAIKFMAYEQIKRLVG 272
Score = 33.5 bits (75), Expect = 0.17
Identities = 33/144 (22%), Positives = 49/144 (34%), Gaps = 8/144 (5%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
+I E + F+KG + I + VY L H + P +
Sbjct: 325 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET--LKNAWLQHYAVNSADPGVFVLLA 382
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
G P L++ R+Q Q G+P I R EG GL+
Sbjct: 383 CGTMSSTCGQLASYPLALVRTRMQAQASIE---GAPEVTMSS---LFKHILRTEGAFGLY 436
Query: 123 RGAWALTLRDTPTVGIYFITYEGL 146
RG ++ P V I ++ YE L
Sbjct: 437 RGLAPNFMKVIPAVSISYVVYENL 460
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 73.6 bits (179), Expect = 2e-13
Identities = 61/218 (27%), Positives = 92/218 (42%), Gaps = 13/218 (5%)
Query: 28 NSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN 87
+S +F V N L V + +ER Q + +AG G + C AP D +KV +Q
Sbjct: 57 HSTIFDVGEN-LTVPDEFTVEER--QTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQV 113
Query: 88 QTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLC 147
G V + RE G R L+RG L+ P I F+ YE +
Sbjct: 114 HASRSNN--------MGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIK 165
Query: 148 RQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSS 207
R + + LVAG AG + + P++++K+RM + + Y GMLDC
Sbjct: 166 RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALR--KTGQYSGMLDCARRI 223
Query: 208 IRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWW 245
+ +EG+ F++G N P + YE L W
Sbjct: 224 LAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAW 261
Score = 47.8 bits (112), Expect = 9e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 222
LVAGG AG S PLD +K MQ+ R G++ IR+ G +RG I
Sbjct: 87 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSN-NMGIVGGFTQMIREGGARSLWRGNGI 145
Query: 223 NSARAFPVNAVTFLSYEYLLRWWG 246
N + P +A+ F++YE + R G
Sbjct: 146 NVLKIAPESAIKFMAYEQIKRLVG 169
Score = 33.5 bits (75), Expect = 0.17
Identities = 33/144 (22%), Positives = 49/144 (34%), Gaps = 8/144 (5%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
+I E + F+KG + I + VY L H + P +
Sbjct: 222 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET--LKNAWLQHYAVNSADPGVFVLLA 279
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
G P L++ R+Q Q G+P I R EG GL+
Sbjct: 280 CGTMSSTCGQLASYPLALVRTRMQAQASIE---GAPEVTMSS---LFKHILRTEGAFGLY 333
Query: 123 RGAWALTLRDTPTVGIYFITYEGL 146
RG ++ P V I ++ YE L
Sbjct: 334 RGLAPNFMKVIPAVSISYVVYENL 357
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 73.6 bits (179), Expect = 2e-13
Identities = 61/218 (27%), Positives = 92/218 (42%), Gaps = 13/218 (5%)
Query: 28 NSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN 87
+S +F V N L V + +ER Q + +AG G + C AP D +KV +Q
Sbjct: 194 HSTIFDVGEN-LTVPDEFTVEER--QTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQV 250
Query: 88 QTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLC 147
G V + RE G R L+RG L+ P I F+ YE +
Sbjct: 251 HASRSNN--------MGIVGGFTQMIREGGARSLWRGNGINVLKIAPESAIKFMAYEQIK 302
Query: 148 RQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSS 207
R + + LVAG AG + + P++++K+RM + + Y GMLDC
Sbjct: 303 RLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALR--KTGQYSGMLDCARRI 360
Query: 208 IRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWW 245
+ +EG+ F++G N P + YE L W
Sbjct: 361 LAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETLKNAW 398
Score = 47.8 bits (112), Expect = 9e-06
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 222
LVAGG AG S PLD +K MQ+ R G++ IR+ G +RG I
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSN-NMGIVGGFTQMIREGGARSLWRGNGI 282
Query: 223 NSARAFPVNAVTFLSYEYLLRWWG 246
N + P +A+ F++YE + R G
Sbjct: 283 NVLKIAPESAIKFMAYEQIKRLVG 306
Score = 33.5 bits (75), Expect = 0.17
Identities = 33/144 (22%), Positives = 49/144 (34%), Gaps = 8/144 (5%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
+I E + F+KG + I + VY L H + P +
Sbjct: 359 RILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYET--LKNAWLQHYAVNSADPGVFVLLA 416
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
G P L++ R+Q Q G+P I R EG GL+
Sbjct: 417 CGTMSSTCGQLASYPLALVRTRMQAQASIE---GAPEVTMSS---LFKHILRTEGAFGLY 470
Query: 123 RGAWALTLRDTPTVGIYFITYEGL 146
RG ++ P V I ++ YE L
Sbjct: 471 RGLAPNFMKVIPAVSISYVVYENL 494
>gi|21361114 solute carrier family 25 (mitochondrial carrier;
oxoglutarate carrier), member 11 [Homo sapiens]
Length = 314
Score = 73.6 bits (179), Expect = 2e-13
Identities = 58/186 (31%), Positives = 81/186 (43%), Gaps = 16/186 (8%)
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
FL G G + P DL+K R+Q E G+ Y+ H SI + EG RG
Sbjct: 25 FLFGGLAGMGATVFVQPLDLVKNRMQLSGE-----GAKTREYKTSFHALTSILKAEGLRG 79
Query: 121 LFRGAWALTLRD----TPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVA 176
++ G A LR T +GIY + +E L +G P V G AG
Sbjct: 80 IYTGLSAGLLRQATYTTTRLGIYTVLFERLTGA---DGTPPGFLLKAVIGMTAGATGAFV 136
Query: 177 ATPLDMIKSRMQMDGL----RRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNA 232
TP ++ RM DG +RR Y+ + + ++ R+EG+ +RG ARA VNA
Sbjct: 137 GTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNA 196
Query: 233 VTFLSY 238
SY
Sbjct: 197 AQLASY 202
Score = 58.5 bits (140), Expect = 5e-09
Identities = 57/246 (23%), Positives = 97/246 (39%), Gaps = 15/246 (6%)
Query: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI 60
+ I + E L G + G+S + A + G+Y+ LT PP ++
Sbjct: 68 LTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGAD-----GTPPGFLLK 122
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
+ G T G A+ P ++ +R+ T P Y+ + I REEG
Sbjct: 123 AVIGMTAGATGAFVGTPAEVALIRM---TADGRLPADQRRGYKNVFNALIRITREEGVLT 179
Query: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATV-LVAGGFAGIASWVAATP 179
L+RG R +Y + G + A +G+ + A+ P
Sbjct: 180 LWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMP 239
Query: 180 LDMIKSRMQ----MDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTF 235
+D+ K+R+Q +DG + Y+ LD + +R EG ++G T AR P +TF
Sbjct: 240 VDIAKTRIQNMRMIDG--KPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTF 297
Query: 236 LSYEYL 241
+ E +
Sbjct: 298 IFLEQM 303
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 72.4 bits (176), Expect = 3e-13
Identities = 58/194 (29%), Positives = 86/194 (44%), Gaps = 6/194 (3%)
Query: 54 PPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIF 113
PP+ FL T P D KVRLQ Q E +A + +Y+G + ++
Sbjct: 10 PPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMV 69
Query: 114 REEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATV-LVAGGFAGIA 172
R EGP + G A R I Y+ + + YTP+G + SS T ++AG G
Sbjct: 70 RTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAM 129
Query: 173 SWVAATPLDMIKSRMQMD---GLRR--RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARA 227
+ A P D++K R Q G R R Y G +D + R+EG+ ++G N R
Sbjct: 130 AVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRN 189
Query: 228 FPVNAVTFLSYEYL 241
VN ++Y+ L
Sbjct: 190 AIVNCAEVVTYDIL 203
Score = 72.0 bits (175), Expect = 4e-13
Identities = 55/192 (28%), Positives = 84/192 (43%), Gaps = 10/192 (5%)
Query: 29 SVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQ 88
S+ G+Y + V T + A S LAGCT G + C P D++KVR Q
Sbjct: 93 SIRIGLYDSVKQVYTP-----KGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQAS 147
Query: 89 TEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCR 148
P +Y G + +I REEG RGL++G +R+ +TY+ L
Sbjct: 148 IH--LGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKE 205
Query: 149 QYTPEGQNPSSATVLVAGGF-AGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSS 207
+ + F AG + V A+P+D++K+R + Y LDCM+
Sbjct: 206 KLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQ--YFSPLDCMIKM 263
Query: 208 IRQEGLGVFFRG 219
+ QEG F++G
Sbjct: 264 VAQEGPTAFYKG 275
Score = 40.8 bits (94), Expect = 0.001
Identities = 31/124 (25%), Positives = 50/124 (40%), Gaps = 20/124 (16%)
Query: 4 IYRHESLLGFFKGMSFPIASIAVVNS---VLFGVYSNTLLVLTATSHQERRAQPPSYMHI 60
I R E + G +KG I A+VN V + + LL + ++
Sbjct: 169 IAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLL--------DYHLLTDNFPCH 220
Query: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
F++ GF +P D++K R N SPP +Y P+ C + +EGP
Sbjct: 221 FVSAFGAGFCATVVASPVDVVKTRYMN---------SPPGQYFSPLDCMIKMVAQEGPTA 271
Query: 121 LFRG 124
++G
Sbjct: 272 FYKG 275
Score = 31.6 bits (70), Expect = 0.66
Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 7/68 (10%)
Query: 152 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRV-------YQGMLDCM 204
P P+ A + G A + + PLD K R+Q+ G + V Y+G+L +
Sbjct: 6 PSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTI 65
Query: 205 VSSIRQEG 212
++ +R EG
Sbjct: 66 LTMVRTEG 73
>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
Length = 338
Score = 72.4 bits (176), Expect = 3e-13
Identities = 62/246 (25%), Positives = 101/246 (41%), Gaps = 24/246 (9%)
Query: 3 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 62
KI R E +G++ I +++ F Y N L H Q S++ +
Sbjct: 93 KIMRTEGFWRPLRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHH----QGNSHLANGI 148
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
AG L + P +++K RLQ +++ + C +++R EG +
Sbjct: 149 AGSMATLLHDAVMNPAEVVKQRLQMYNS----------QHRSAISCIRTVWRTEGLGAFY 198
Query: 123 RGAWALTLRDTPTVGIYFITYEGLCRQYTP-EGQNPSSATVLVAGGFAGIASWVAATPLD 181
R + P I+FITYE L Q P NP S +++GG AG + A TPLD
Sbjct: 199 RSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSH--IISGGLAGALAAAATTPLD 256
Query: 182 MIKSRMQMD---GLRRRVYQGMLDCMVSSIRQ----EGLGVFFRGVTINSARAFPVNAVT 234
+ K+ + L G L M ++ R GL +F+G+ P A++
Sbjct: 257 VCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAIS 316
Query: 235 FLSYEY 240
+ YE+
Sbjct: 317 WSVYEF 322
Score = 68.2 bits (165), Expect = 6e-12
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 13/182 (7%)
Query: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQT-EPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 121
AG G L+ + P D +K R+Q+ + +P+AQ Y I R EG
Sbjct: 51 AGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQ-------YTSIYGALKKIMRTEGFWRP 103
Query: 122 FRGAWALTLRDTPTVGIYFITYEGLCRQYTP--EGQNPSSATVLVAGGFAGIASWVAATP 179
RG + + P +YF YE + R Q S +AG A + P
Sbjct: 104 LRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNP 163
Query: 180 LDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 239
+++K R+QM + R + C+ + R EGLG F+R T P ++ F++YE
Sbjct: 164 AEVVKQRLQMYNSQHR---SAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYE 220
Query: 240 YL 241
+L
Sbjct: 221 FL 222
Score = 41.2 bits (95), Expect = 8e-04
Identities = 29/91 (31%), Positives = 44/91 (48%), Gaps = 4/91 (4%)
Query: 157 PSSATV---LVAGGFAGIASWVAATPLDMIKSRMQ-MDGLRRRVYQGMLDCMVSSIRQEG 212
P+SA+V + AG AGI P+D +K+RMQ + + Y + + +R EG
Sbjct: 40 PTSASVSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEG 99
Query: 213 LGVFFRGVTINSARAFPVNAVTFLSYEYLLR 243
RGV + A P +A+ F YE + R
Sbjct: 100 FWRPLRGVNVMIMGAGPAHAMYFACYENMKR 130
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,808,343
Number of Sequences: 37866
Number of extensions: 452356
Number of successful extensions: 2319
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 1718
Number of HSP's gapped (non-prelim): 251
length of query: 246
length of database: 18,247,518
effective HSP length: 100
effective length of query: 146
effective length of database: 14,460,918
effective search space: 2111294028
effective search space used: 2111294028
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.