Search of human proteins with 22547189

Search of human proteins with 22547189

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22547189 serine hydroxymethyltransferase 1 (soluble) isoform
2 [Homo sapiens]
         (444 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22547189 serine hydroxymethyltransferase 1 (soluble) isoform ...   897   0.0  
gi|22547186 serine hydroxymethyltransferase 1 (soluble) isoform ...   878   0.0  
gi|19923315 serine hydroxymethyltransferase 2 (mitochondrial) [H...   536   e-152
gi|195546900 suppressor of Ty 5 homolog isoform a [Homo sapiens]       33   0.52 
gi|161169023 suppressor of Ty 5 homolog isoform a [Homo sapiens]       33   0.52 
gi|20149524 suppressor of Ty 5 homolog isoform a [Homo sapiens]        33   0.52 
gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens]         29   7.5  
gi|195546902 suppressor of Ty 5 homolog isoform b [Homo sapiens]       29   7.5  
gi|58000461 zinc finger protein 648 [Homo sapiens]                     29   9.8  

>gi|22547189 serine hydroxymethyltransferase 1 (soluble) isoform 2
           [Homo sapiens]
          Length = 444

 Score =  897 bits (2318), Expect = 0.0
 Identities = 444/444 (100%), Positives = 444/444 (100%)

Query: 1   MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA 60
           MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
Sbjct: 1   MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA 60

Query: 61  VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG 120
           VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
Sbjct: 61  VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG 120

Query: 121 SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY 180
           SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
Sbjct: 121 SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY 180

Query: 181 INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV 240
           INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
Sbjct: 181 INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV 240

Query: 241 VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVAVALKQAMTLEFKVYQHQVVANCRALS 300
           VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVAVALKQAMTLEFKVYQHQVVANCRALS
Sbjct: 241 VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVAVALKQAMTLEFKVYQHQVVANCRALS 300

Query: 301 EALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPS 360
           EALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPS
Sbjct: 301 EALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPS 360

Query: 361 GLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQA 420
           GLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQA
Sbjct: 361 GLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQA 420

Query: 421 AVQALREEVESFASLFPLPGLPDF 444
           AVQALREEVESFASLFPLPGLPDF
Sbjct: 421 AVQALREEVESFASLFPLPGLPDF 444


>gi|22547186 serine hydroxymethyltransferase 1 (soluble) isoform 1
           [Homo sapiens]
          Length = 483

 Score =  878 bits (2268), Expect = 0.0
 Identities = 444/483 (91%), Positives = 444/483 (91%), Gaps = 39/483 (8%)

Query: 1   MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA 60
           MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
Sbjct: 1   MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA 60

Query: 61  VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG 120
           VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
Sbjct: 61  VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG 120

Query: 121 SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY 180
           SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
Sbjct: 121 SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY 180

Query: 181 INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV 240
           INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
Sbjct: 181 INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV 240

Query: 241 VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRK----------------------------- 271
           VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRK                             
Sbjct: 241 VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL 300

Query: 272 ----------GVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL 321
                     GVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
Sbjct: 301 QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL 360

Query: 322 VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK 381
           VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
Sbjct: 361 VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK 420

Query: 382 VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL 441
           VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
Sbjct: 421 VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL 480

Query: 442 PDF 444
           PDF
Sbjct: 481 PDF 483


>gi|19923315 serine hydroxymethyltransferase 2 (mitochondrial) [Homo
           sapiens]
          Length = 504

 Score =  536 bits (1382), Expect = e-152
 Identities = 275/460 (59%), Positives = 335/460 (72%), Gaps = 43/460 (9%)

Query: 24  QPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYY 83
           + L DSD E++ ++++E +RQ  GLELIASENF SRA LEALGSCLNNKYSEGYPG+RYY
Sbjct: 47  ESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYY 106

Query: 84  GGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDL 143
           GG E +DE+E LCQ+RAL+A+ LDP  WGVNVQPYSGSPAN AVYTAL++PH RIMGLDL
Sbjct: 107 GGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDL 166

Query: 144 PDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTS 203
           PDGGHLTHG+M+D K+ISATSIFFESMPYK+NP TG I+Y+QL   ARLF P+LIIAGTS
Sbjct: 167 PDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTS 226

Query: 204 CYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCR 263
            Y+R ++YAR+R++ DE  A+L+ADMAHISGLVAA V+PSPF+H  +VTTTTHKTLRG R
Sbjct: 227 AYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGAR 286

Query: 264 AGMIFYRKG---------------------------------------VAVALKQAMTLE 284
           +G+IFYRKG                                       VAVALKQA T  
Sbjct: 287 SGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPM 346

Query: 285 FKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIA 344
           F+ Y  QV+ N RA+++AL E GY +V+GG+DNHL+LVDLR KG DG RAE+VLE  SI 
Sbjct: 347 FREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSIT 406

Query: 345 CNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRA 404
            NKNTCPGDRSA+ P GLRLG PALTSR   E DF++V  FI  G+ + L+++S T   A
Sbjct: 407 ANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKT---A 463

Query: 405 TLKEFKERLAGDKYQAAVQA-LREEVESFASLFPLPGLPD 443
            L++FK  L  D   +   A LR+ VE FA  FP+PG  +
Sbjct: 464 KLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDE 503


>gi|195546900 suppressor of Ty 5 homolog isoform a [Homo sapiens]
          Length = 1087

 Score = 33.1 bits (74), Expect = 0.52
 Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 10/110 (9%)

Query: 5   VNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEA 64
           V+  ++D D W    + +   L+  ++E  NI     +  R G   +  +N       E 
Sbjct: 82  VDDEYEDEDQWEDGAEDI---LEKEEIEASNIDNVVLDEDRSGARRL--QNLWRDQREEE 136

Query: 65  LGSCLNNKYSEGYPGQRYYGGTEFIDEL-ETLCQKRALQAYKLDPQCWGV 113
           LG     KY++   G+  YGG+   DEL + + Q++ L   K DP  W V
Sbjct: 137 LGEYYMKKYAKSSVGETVYGGS---DELSDDITQQQLLPGVK-DPNLWTV 182


>gi|161169023 suppressor of Ty 5 homolog isoform a [Homo sapiens]
          Length = 1087

 Score = 33.1 bits (74), Expect = 0.52
 Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 10/110 (9%)

Query: 5   VNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEA 64
           V+  ++D D W    + +   L+  ++E  NI     +  R G   +  +N       E 
Sbjct: 82  VDDEYEDEDQWEDGAEDI---LEKEEIEASNIDNVVLDEDRSGARRL--QNLWRDQREEE 136

Query: 65  LGSCLNNKYSEGYPGQRYYGGTEFIDEL-ETLCQKRALQAYKLDPQCWGV 113
           LG     KY++   G+  YGG+   DEL + + Q++ L   K DP  W V
Sbjct: 137 LGEYYMKKYAKSSVGETVYGGS---DELSDDITQQQLLPGVK-DPNLWTV 182


>gi|20149524 suppressor of Ty 5 homolog isoform a [Homo sapiens]
          Length = 1087

 Score = 33.1 bits (74), Expect = 0.52
 Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 10/110 (9%)

Query: 5   VNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEA 64
           V+  ++D D W    + +   L+  ++E  NI     +  R G   +  +N       E 
Sbjct: 82  VDDEYEDEDQWEDGAEDI---LEKEEIEASNIDNVVLDEDRSGARRL--QNLWRDQREEE 136

Query: 65  LGSCLNNKYSEGYPGQRYYGGTEFIDEL-ETLCQKRALQAYKLDPQCWGV 113
           LG     KY++   G+  YGG+   DEL + + Q++ L   K DP  W V
Sbjct: 137 LGEYYMKKYAKSSVGETVYGGS---DELSDDITQQQLLPGVK-DPNLWTV 182


>gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens]
          Length = 815

 Score = 29.3 bits (64), Expect = 7.5
 Identities = 15/41 (36%), Positives = 27/41 (65%), Gaps = 4/41 (9%)

Query: 223 AYLMADMAHISG---LVAAGVVPSPFEHCHVVTTTTHKTLR 260
           AYL A++ H+SG   L+A+GVV  P+   + ++  +H T++
Sbjct: 341 AYLSAELFHLSGIMALIASGVVMRPYVEAN-ISHKSHTTIK 380


>gi|195546902 suppressor of Ty 5 homolog isoform b [Homo sapiens]
          Length = 1083

 Score = 29.3 bits (64), Expect = 7.5
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 10/85 (11%)

Query: 35  NIIKKESNRQRVGLELIAS-----ENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFI 89
           +I++K SN   V L+   S     +N       E LG     KY++   G+  YGG+   
Sbjct: 98  DILEKASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGS--- 154

Query: 90  DEL-ETLCQKRALQAYKLDPQCWGV 113
           DEL + + Q++ L   K DP  W V
Sbjct: 155 DELSDDITQQQLLPGVK-DPNLWTV 178


>gi|58000461 zinc finger protein 648 [Homo sapiens]
          Length = 568

 Score = 28.9 bits (63), Expect = 9.8
 Identities = 13/36 (36%), Positives = 20/36 (55%)

Query: 316 DNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCP 351
           D  ++ ++L S   DGG AEK   A  +AC + + P
Sbjct: 25  DTQMLSMNLESDDEDGGEAEKEGTADPVACPRGSSP 60


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,967,715
Number of Sequences: 37866
Number of extensions: 751568
Number of successful extensions: 1455
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1448
Number of HSP's gapped (non-prelim): 10
length of query: 444
length of database: 18,247,518
effective HSP length: 105
effective length of query: 339
effective length of database: 14,271,588
effective search space: 4838068332
effective search space used: 4838068332
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.