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Search of human proteins with 223468659
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223468659 kelch repeat and BTB (POZ) domain containing 2
[Homo sapiens]
(623 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 1272 0.0
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 332 6e-91
gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo... 218 1e-56
gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo... 218 1e-56
gi|40807500 kelch-like 20 [Homo sapiens] 200 3e-51
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 197 3e-50
gi|148664248 kelch domain containing 6 [Homo sapiens] 193 3e-49
gi|166235129 kelch-like 3 [Homo sapiens] 190 4e-48
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 187 2e-47
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 187 2e-47
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 186 4e-47
gi|40018614 DRE1 protein [Homo sapiens] 183 4e-46
gi|11056006 kelch-like 12 [Homo sapiens] 181 1e-45
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 179 5e-45
gi|14780904 kelch-like 1 protein [Homo sapiens] 178 1e-44
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 177 2e-44
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 177 3e-44
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 177 3e-44
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 176 4e-44
gi|40255071 kelch-like 23 [Homo sapiens] 176 4e-44
gi|38327518 BTB and kelch domain containing 3 [Homo sapiens] 176 7e-44
gi|38327516 BTB and kelch domain containing 3 [Homo sapiens] 176 7e-44
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 175 1e-43
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 175 1e-43
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 175 1e-43
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 174 3e-43
gi|128485503 kelch-like 30 [Homo sapiens] 174 3e-43
gi|194097389 kelch-like 38 [Homo sapiens] 172 6e-43
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 169 5e-42
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 169 5e-42
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 1272 bits (3292), Expect = 0.0
Identities = 623/623 (100%), Positives = 623/623 (100%)
Query: 1 MSTQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMF 60
MSTQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMF
Sbjct: 1 MSTQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMF 60
Query: 61 MSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRC 120
MSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRC
Sbjct: 61 MSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRC 120
Query: 121 REYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDI 180
REYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDI
Sbjct: 121 REYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDI 180
Query: 181 LSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPN 240
LSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPN
Sbjct: 181 LSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPN 240
Query: 241 DKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCS 300
DKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCS
Sbjct: 241 DKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCS 300
Query: 301 PPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTW 360
PPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTW
Sbjct: 301 PPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTW 360
Query: 361 FPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQ 420
FPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQ
Sbjct: 361 FPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQ 420
Query: 421 WSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIA 480
WSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIA
Sbjct: 421 WSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIA 480
Query: 481 TNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRE 540
TNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRE
Sbjct: 481 TNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRE 540
Query: 541 THLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPT 600
THLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPT
Sbjct: 541 THLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPT 600
Query: 601 YLFSTDGTEEFELDGEMVALPPV 623
YLFSTDGTEEFELDGEMVALPPV
Sbjct: 601 YLFSTDGTEEFELDGEMVALPPV 623
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 332 bits (851), Expect = 6e-91
Identities = 199/594 (33%), Positives = 307/594 (51%), Gaps = 38/594 (6%)
Query: 13 YAVSLLEQLKLFYEQQLFTDIVLIVE-GTEFPCHKMVLATCSSYFRAMFMSGLSESKQTH 71
+A S+L+QLK Y++ TDIV+ V+ G F CH+ VLA S YFR+MF SGL+ES Q
Sbjct: 31 HACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE 90
Query: 72 VHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 131
V + V+A ++ +++ YAYT + + ++ V+ L+ A Q+ + +C +Y+I ++ +
Sbjct: 91 VRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQ 150
Query: 132 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKE 191
N + + FAD + +EL +K + KF V + F+QL+ D LI IL SD+LNV++E
Sbjct: 151 NSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDRE 210
Query: 192 ETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYK 251
E V E+ + W E+ R +L + ++ L E T + + +PP + + +
Sbjct: 211 EHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDT---FIEKIPPQFAQAIAKSCVE 267
Query: 252 SMPKFFK---PRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKV 308
P RLGMT EM+I +A+ ++ + C +V+KLC PP DL +V
Sbjct: 268 KGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREV 327
Query: 309 GTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLF 368
G +V+PDNDIYIAGG P +S++ + N F+ +D N W K +L
Sbjct: 328 GILVSPDNDIYIAGGYRP---------SSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLR 378
Query: 369 VRIKPSLVCCEGYIYAIGGDSVGGE--LNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVV 426
RI LV C G +YAIGG G+ + ++VE YD+ ++ WT V +P A ++ AV
Sbjct: 379 ARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVE 438
Query: 427 VHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIR 486
+ IYV+ Y P+ D W + R AA + D I+YI G + R
Sbjct: 439 YKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAG---TCGNHQR 495
Query: 487 LPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHL--- 543
+ TVE YD+ N+W + P + +P ++ V+ N L +F+R T +
Sbjct: 496 M---------FTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVE 546
Query: 544 ----NERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEE 593
K YQYD D+W +R LWDLGR F C V KLYP CL++
Sbjct: 547 EHVFRTSRKNSLYQYDDIADQWMKVYETPDR-LWDLGRHFECAVAKLYPQCLQK 599
>gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo
sapiens]
Length = 674
Score = 218 bits (556), Expect = 1e-56
Identities = 167/643 (25%), Positives = 291/643 (45%), Gaps = 106/643 (16%)
Query: 3 TQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIV--------EGTEFPCHKMVLATCSS 54
T E +T ++ +LL QLK FY+ +L D+ + V G FPC++ VLA
Sbjct: 35 TGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACP 94
Query: 55 YFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVE 114
YF++MF G+ ES+Q V + +VDA + ++++ Y YTG ++++++ VE+LY + LQ+E
Sbjct: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLE 154
Query: 115 DVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYH-----QDAF 169
V + C +L ++++ NC +L FAD F +L+ A+ + F + H ++
Sbjct: 155 YVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETL 214
Query: 170 MQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVT 229
L+ L+ +L D+L+VE E+TV A+ WLE + R + V +R +E
Sbjct: 215 ADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEED 274
Query: 230 QRAWFQGL--PPNDKSV---VVQG---------LYKSM-------------------PKF 256
Q + +GL P K V++G LYKS+ +
Sbjct: 275 Q-DYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAEN 333
Query: 257 FKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVT--- 313
RLGM +EM+IF + +C P + +YK+ SP L TV T
Sbjct: 334 PPQRLGMCAKEMVIFFGHPRD------PFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAV 387
Query: 314 ---PDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVR 370
PD+DIY+A +T+ + + QN+W L R
Sbjct: 388 CISPDHDIYLAA------QPRTD----------------LWVYKPAQNSWQQLADRLLCR 425
Query: 371 IKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDC 430
+ GYIY +GG + + VE Y+ ++++W +V+PLP ++ +V+ D
Sbjct: 426 EGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDY 485
Query: 431 IYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSG 490
+Y + M+CY P + W++ + + F A F ++I+ I + +
Sbjct: 486 LYALNSKRMFCYDPSHNMWLKCVSLKRN-DFQEACVFNEEIYCICDIPV----------- 533
Query: 491 TVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYV 550
+++Y+ + EW+ NIP ++ R + L + T ++ +
Sbjct: 534 --------MKVYNPVRAEWRQMNNIPLVSETNN-YRIIKHGQKLLLITSRTPQWKKNRVT 584
Query: 551 TYQYDLELDRWSLRQHISERV-LWDLGRDFRCTVGKLYPSCLE 592
Y+YD+ D+W +I + L +F C ++YPSCLE
Sbjct: 585 VYEYDIRGDQWI---NIGTTLGLLQFDSNFFCLSARVYPSCLE 624
>gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo
sapiens]
Length = 684
Score = 218 bits (556), Expect = 1e-56
Identities = 173/672 (25%), Positives = 297/672 (44%), Gaps = 117/672 (17%)
Query: 3 TQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIV--------EGTEFPCHKMVLATCSS 54
T E +T ++ +LL QLK FY+ +L D+ + V G F C++ VLA
Sbjct: 35 TGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACP 94
Query: 55 YFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVE 114
YF++MF G+ ES+Q V + +VDA + ++++ Y YTG ++++++ V++LY + LQ+E
Sbjct: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLE 154
Query: 115 DVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAV-----YHQDAF 169
V + C +L ++++ NC +L FAD F +L+ A+ + H F + ++
Sbjct: 155 YVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETL 214
Query: 170 MQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVT 229
L+ L+ +L D+L++E E TV A+ WLE + R + V +R +E
Sbjct: 215 ADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEED 274
Query: 230 QRAWFQGL--PPNDKSV---VVQG---------LYKSM-------------------PKF 256
Q + +GL P K V++G LYKS+ +
Sbjct: 275 Q-DYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAEN 333
Query: 257 FKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTV----- 311
RLGM +EM+IF + +CY P + +Y + SP TV
Sbjct: 334 PPQRLGMCAKEMVIFFGHPRD------PFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAV 387
Query: 312 -VTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVR 370
V+PD+DIY+A P K+ + + QN+W L R
Sbjct: 388 CVSPDHDIYLAA--QPRKD--------------------LWVYKPAQNSWQQLADRLLCR 425
Query: 371 IKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDC 430
+ GYIY +GG + + VE Y ++++W +V+P+P ++ +VV +
Sbjct: 426 EGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNY 485
Query: 431 IYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSG 490
+Y + M CY P + W+ A + S F A F D+I+ I + +
Sbjct: 486 LYAVNSKRMLCYDPSHNMWLNCASLKRS-DFQEACVFNDEIYCICDIPV----------- 533
Query: 491 TVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYV 550
+++Y+ + EW+ +NIP + + V L + T ++ +
Sbjct: 534 --------MKVYNPARGEWRRISNIPLDSETHN-YQIVNHDQKLLLITSTTPQWKKNRVT 584
Query: 551 TYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPTYLFST----- 605
Y+YD D+W + + +D G F C ++YPSCLE P F T
Sbjct: 585 VYEYDTREDQWINIGTMLGLLQFDSG--FICLCARVYPSCLE------PGQSFITEEDDA 636
Query: 606 --DGTEEFELDG 615
+ + E++LDG
Sbjct: 637 RSESSTEWDLDG 648
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 200 bits (509), Expect = 3e-51
Identities = 148/566 (26%), Positives = 255/566 (45%), Gaps = 75/566 (13%)
Query: 9 INTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESK 68
I+ ++ LE + L + + D+VL+V + H+++L+ CS YFRAMF L+ES+
Sbjct: 46 ISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR 105
Query: 69 QTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKI 128
QT V +R++D ++++I +AYT + + + V+ L AC LQ+ ++ + C E+L +++
Sbjct: 106 QTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQL 165
Query: 129 NAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNV 188
+ NC+ + +FAD SC EL + A + +H F V + FM L + LIDI+SSD LNV
Sbjct: 166 DPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNV 225
Query: 189 EKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSE------------VTQRAWFQG 236
EE V A M W++Y+ + R L VL +R+ LS + +
Sbjct: 226 RSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRD 285
Query: 237 LPPNDKSVVVQGLYKSMPKFFKPRLGMTKE---EMMIFIEASSENPCSLYSSVCYSPQAE 293
L K+ ++ L + P PR K ++F + ++ S Y PQ
Sbjct: 286 LVDEAKNYLL--LPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTN 343
Query: 294 KVYKLCSPPADLHKVGTVVTPDNDIYIAGG--------QVPLKNTKTNH-----SKTSKL 340
+ + S VG V D+ +Y GG V + KTN + TS
Sbjct: 344 EWRMVASMSKRRCGVGVSVL-DDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTC 402
Query: 341 QTA------------------FRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYI 382
+T+ +N +D ++N W M R+ ++ G++
Sbjct: 403 RTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFL 462
Query: 383 YAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM-------T 435
YA+GG LN TVERY+ +++ W ++P+ + V D IY +
Sbjct: 463 YAVGGSDGTSPLN--TVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTE 520
Query: 436 LNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGS 495
L+ Y PR++ W + + RS A ++ +GG DG+
Sbjct: 521 LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGF---------------DGT 565
Query: 496 SV--TVEIYDVNKNEWKMAANIPAKR 519
+ T+E++D + N W++ + +R
Sbjct: 566 TYLKTIEVFDPDANTWRLYGGMNYRR 591
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 197 bits (500), Expect = 3e-50
Identities = 148/553 (26%), Positives = 236/553 (42%), Gaps = 76/553 (13%)
Query: 13 YAVSLLEQ-LKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTH 71
Y +LL+ LK +++ F D L PCH+++L+ CS YFR F+S + E+K+
Sbjct: 14 YQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKE 73
Query: 72 VHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 131
V L NVD A L +II Y Y+ ++ +ND V+ ++ A Q+ V C YL K++
Sbjct: 74 VVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPG 133
Query: 132 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKE 191
NC+ +L L C L SA+ V +F + ++ FMQLS LI ++S+D+LNVEKE
Sbjct: 134 NCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKE 193
Query: 192 ETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSE------------------------ 227
E V EA M W+ + E+R + LS V IR ++E
Sbjct: 194 EAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIK 253
Query: 228 VTQRAWFQGLPPNDKSVVVQGLYK---------SMPKFFK--PRLGMTKEEMMIFIEASS 276
V + A+ LP K+ G + +P + PR GM +++++ + +
Sbjct: 254 VLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDT- 312
Query: 277 ENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSK 336
++V Y P + Y ++VT N IY+ GG +K
Sbjct: 313 -------AAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLY-----VDEENK 360
Query: 337 TSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNR 396
LQ + F+ D+ + W P+ R L + IY + G + E +
Sbjct: 361 DQPLQ------SYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASL 414
Query: 397 RTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM--------TLNLMYCYFPRSDS 448
+V YD +W V LP + IY + N ++ + P+
Sbjct: 415 DSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGD 474
Query: 449 WVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNE 508
W ++A + RS A KI GG+ T DG S +VE +D+ N+
Sbjct: 475 WKDLAPMKIPRSMFGVAVHKGKIVIAGGV-------------TEDGLSASVEAFDLTTNK 521
Query: 509 WKMAANIPAKRYS 521
W + P +R S
Sbjct: 522 WDVMTEFPQERSS 534
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 193 bits (491), Expect = 3e-49
Identities = 159/634 (25%), Positives = 283/634 (44%), Gaps = 60/634 (9%)
Query: 1 MSTQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMF 60
M + E + +++++LL +++ E D+VL EG +FPCH++VLA S YF+AMF
Sbjct: 1 MECKIEGKEKYQHSLNLLNKIQNMKELAEMIDVVLTAEGEKFPCHRLVLAAFSPYFKAMF 60
Query: 61 MSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRC 120
GL E Q V L ++ A ++ +++ Y Y L +N++ V+ + A F+Q+E+V C
Sbjct: 61 TCGLLECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVC 120
Query: 121 REYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDI 180
++Y++ ++A NC+ + FA E+L +K+ + F V + +++ + +
Sbjct: 121 QKYMMDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEVSLHEEILEIEVHQFLTL 180
Query: 181 LSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPN 240
+ SD+LN+ +EE++ + + W+ +N E R+ +L +L Q+R++ ++ R Q L N
Sbjct: 181 IKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVRLELVNPSFLR---QALRRN 237
Query: 241 -------DKSVVVQGLYKSM----PKFFKPRLGMTKEEMMIFIEASSENPCSLY-----S 284
D ++Q +K++ R GM +++ I +S S + +
Sbjct: 238 TMLLCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYGDA 297
Query: 285 SVCYSPQAEKVYKLCSPP--ADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQT 342
S CY P + K Y + SP L V T V +N+ I G+ +K ++
Sbjct: 298 SFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENNTIIVAGEASASKLSRQKNKNVEI-- 355
Query: 343 AFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDS--VGGELNRRTVE 400
Y + + N ++ K R +L +Y IGG L V+
Sbjct: 356 --------YRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQYLITNCVD 407
Query: 401 RYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM----------------TLNLMYCYFP 444
+Y E+D W VSPLP A V V++ +YV+ N + Y P
Sbjct: 408 KYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYDP 467
Query: 445 RSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDV 504
D W A + S+ S A +I+ +GG+ + G V VEIY+
Sbjct: 468 SQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGI-----GCVGQDKGQVRKCLDVVEIYNP 522
Query: 505 NKNEWKMAANIPAKRYS--DPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWS 562
+ + W+ +P+ S A + L V H +R + ++ + LELD W
Sbjct: 523 DGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYV-CGGFHGADRHEVISKEI-LELDPWE 580
Query: 563 LRQH-ISERVLWDLGRDFRCTVGKLYPSCLEESP 595
+ + ++ VL D C V ++ P L P
Sbjct: 581 NQWNVVAINVLMHDSYDV-CLVARMNPRDLIPPP 613
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 190 bits (482), Expect = 4e-48
Identities = 137/502 (27%), Positives = 224/502 (44%), Gaps = 76/502 (15%)
Query: 27 QQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIII 86
+QL D++++ E E H++VLA CS YF AMF +SESK + +++VD TL +I
Sbjct: 46 KQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLI 105
Query: 87 TYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCE 146
Y YT + + + V+ L A LQ+ DV Q C ++L +++ NC+ + +FAD+ +C
Sbjct: 106 DYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCT 165
Query: 147 ELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNT 206
+L Q A E F V + F+ LS D + ++SSD L V EE V EA + W+ Y
Sbjct: 166 DLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEK 225
Query: 207 ESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMTKE 266
E+R ++++ ++ +R+ L P D V +E
Sbjct: 226 ETRLEHMAKLMEHVRLPLL-------------PRDYLVQT-----------------VEE 255
Query: 267 EMMIFIEASSENPCS--LYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQ 324
E +I + N C L ++ Y L P K T V+ + + GGQ
Sbjct: 256 EALI----KNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRT--KPRTPVSLPKVMIVVGGQ 309
Query: 325 VPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYA 384
P A R+V C+ D +++ W + R + +V G++YA
Sbjct: 310 AP---------------KAIRSVECY---DFEEDRWDQIAELPSRRCRAGVVFMAGHVYA 351
Query: 385 IGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVMT-------LN 437
+GG G L RTV+ YD KD+WT ++ + A V++D +Y + L
Sbjct: 352 VGG--FNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLA 409
Query: 438 LMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSV 497
+ Y +++ W +A T RS K++ +GG A+ +
Sbjct: 410 SVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLS----------- 458
Query: 498 TVEIYDVNKNEWKMAANIPAKR 519
TVE Y+ NEW A++ +R
Sbjct: 459 TVEQYNPATNEWIYVADMSTRR 480
Score = 50.8 bits (120), Expect = 4e-06
Identities = 39/143 (27%), Positives = 59/143 (41%), Gaps = 26/143 (18%)
Query: 390 VGGELNR--RTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYV-------MTLNLMY 440
VGG+ + R+VE YD E+D W ++ LP + V + +Y + + +
Sbjct: 306 VGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVD 365
Query: 441 CYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSS--VT 498
Y D W +A Q RS AA D ++ +GG DGS+ +
Sbjct: 366 VYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGF---------------DGSTGLAS 410
Query: 499 VEIYDVNKNEWKMAANIPAKRYS 521
VE Y NEW A + +R S
Sbjct: 411 VEAYSYKTNEWFFVAPMNTRRSS 433
Score = 39.7 bits (91), Expect = 0.008
Identities = 21/77 (27%), Positives = 35/77 (45%), Gaps = 3/77 (3%)
Query: 353 FDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMV 412
+D NTW M R + G +Y +GGD G N +VE Y+ D+WT++
Sbjct: 510 YDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDD--GSCNLASVEYYNPVTDKWTLL 567
Query: 413 -SPLPCAWQWSAAVVVH 428
+ + ++ V+H
Sbjct: 568 PTNMSTGRSYAGVAVIH 584
Score = 38.5 bits (88), Expect = 0.019
Identities = 31/121 (25%), Positives = 49/121 (40%), Gaps = 10/121 (8%)
Query: 353 FDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMV 412
++ N W M R + G +YA GG G L R++VE YD + W V
Sbjct: 463 YNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHD--GPLVRKSVEVYDPGTNTWKQV 520
Query: 413 SPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMR-QTSRSFASA 464
+ + + + V+ +YV+ L + Y P +D W + T RS+A
Sbjct: 521 ADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGV 580
Query: 465 A 465
A
Sbjct: 581 A 581
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 187 bits (475), Expect = 2e-47
Identities = 131/502 (26%), Positives = 223/502 (44%), Gaps = 76/502 (15%)
Query: 27 QQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIII 86
Q L D+ ++ E E H++VLA CS YF AMF +SES+ V ++ VD TL+++I
Sbjct: 56 QNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLI 115
Query: 87 TYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCE 146
Y YT + + + V+ L A LQ++DV + C E+L +++ NC+ + +FAD+ +C
Sbjct: 116 DYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACT 175
Query: 147 ELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNT 206
+L A E F V + F+ L + + ++SSD L + EE V EA + W+ ++
Sbjct: 176 DLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 235
Query: 207 ESRSQYLSSVLSQIRIDALSE--VTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMT 264
+ R ++++ ++ +R+ L + QR + L N S L ++M P T
Sbjct: 236 DVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKN-SSACKDYLIEAMKYHLLP----T 290
Query: 265 KEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQ 324
++ +++ + V P +L K+ VV GGQ
Sbjct: 291 EQRILM----------------------KSVRTRLRTPMNLPKLMVVV---------GGQ 319
Query: 325 VPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYA 384
P A R+V C +D ++ W + R + +V G ++A
Sbjct: 320 AP---------------KAIRSVEC---YDFKEERWHQVAELPSRRCRAGMVYMAGLVFA 361
Query: 385 IGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM-------TLN 437
+GG G L RTV+ YD KD+WT V+ + A V++ +Y + L+
Sbjct: 362 VGG--FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLS 419
Query: 438 LMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSV 497
+ Y +S+ W +A T RS G ++ +GG A+ +
Sbjct: 420 SVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLS----------- 468
Query: 498 TVEIYDVNKNEWKMAANIPAKR 519
TVE Y+ NEW A + +R
Sbjct: 469 TVECYNATTNEWTYIAEMSTRR 490
Score = 40.8 bits (94), Expect = 0.004
Identities = 34/125 (27%), Positives = 53/125 (42%), Gaps = 13/125 (10%)
Query: 346 TVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTE 405
TV C+ +A N W M R + +YA+GG G L R++VE YD
Sbjct: 469 TVECY---NATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD--GPLVRKSVEVYDPT 523
Query: 406 KDEWTMVSPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSW-VEMAMRQT 457
+ W V+ + + + V+ +YV+ L + Y P +D W V + T
Sbjct: 524 TNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMST 583
Query: 458 SRSFA 462
RS+A
Sbjct: 584 GRSYA 588
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 187 bits (475), Expect = 2e-47
Identities = 131/502 (26%), Positives = 223/502 (44%), Gaps = 76/502 (15%)
Query: 27 QQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIII 86
Q L D+ ++ E E H++VLA CS YF AMF +SES+ V ++ VD TL+++I
Sbjct: 52 QNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLI 111
Query: 87 TYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCE 146
Y YT + + + V+ L A LQ++DV + C E+L +++ NC+ + +FAD+ +C
Sbjct: 112 DYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACT 171
Query: 147 ELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNT 206
+L A E F V + F+ L + + ++SSD L + EE V EA + W+ ++
Sbjct: 172 DLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDK 231
Query: 207 ESRSQYLSSVLSQIRIDALSE--VTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMT 264
+ R ++++ ++ +R+ L + QR + L N S L ++M P T
Sbjct: 232 DVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKN-SSACKDYLIEAMKYHLLP----T 286
Query: 265 KEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQ 324
++ +++ + V P +L K+ VV GGQ
Sbjct: 287 EQRILM----------------------KSVRTRLRTPMNLPKLMVVV---------GGQ 315
Query: 325 VPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYA 384
P A R+V C +D ++ W + R + +V G ++A
Sbjct: 316 AP---------------KAIRSVEC---YDFKEERWHQVAELPSRRCRAGMVYMAGLVFA 357
Query: 385 IGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM-------TLN 437
+GG G L RTV+ YD KD+WT V+ + A V++ +Y + L+
Sbjct: 358 VGG--FNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLS 415
Query: 438 LMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSV 497
+ Y +S+ W +A T RS G ++ +GG A+ +
Sbjct: 416 SVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLS----------- 464
Query: 498 TVEIYDVNKNEWKMAANIPAKR 519
TVE Y+ NEW A + +R
Sbjct: 465 TVECYNATTNEWTYIAEMSTRR 486
Score = 40.8 bits (94), Expect = 0.004
Identities = 34/125 (27%), Positives = 53/125 (42%), Gaps = 13/125 (10%)
Query: 346 TVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTE 405
TV C+ +A N W M R + +YA+GG G L R++VE YD
Sbjct: 465 TVECY---NATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD--GPLVRKSVEVYDPT 519
Query: 406 KDEWTMVSPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSW-VEMAMRQT 457
+ W V+ + + + V+ +YV+ L + Y P +D W V + T
Sbjct: 520 TNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMST 579
Query: 458 SRSFA 462
RS+A
Sbjct: 580 GRSYA 584
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 186 bits (473), Expect = 4e-47
Identities = 153/558 (27%), Positives = 252/558 (45%), Gaps = 49/558 (8%)
Query: 13 YAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHV 72
++ LL+ L L + DI+L V + HK+VLA+ S YF+AMF LSE + + V
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 73 HLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAEN 132
+ +D LQ I+ YAYTG + ++ TVE L A LQ++ VL+ C +L +++ N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 133 CVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEE 192
C+ + FA+ + C +L +A + + F AV + F +L+H L +I+S+D LNV EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 193 TVREAAMLWLEYNTESRSQYLSSVLSQIRIDALS-EVTQRAWFQGLPPNDKSVVVQGLYK 251
TV A W++Y+ + R +YL+ +L+ +R+ LS + R + D L +
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 252 SMPKFFKPRLGMTKE-----------EMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCS 300
++ F P ++ + +++ + S L S Y PQ + L
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAP 316
Query: 301 PPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTW 360
++ G V D +Y+ GG TN ++ +V C ++ NTW
Sbjct: 317 LNIPRYEFGICVL-DQKVYVIGG------IATNVRPGVTIRKHENSVEC---WNPDTNTW 366
Query: 361 FPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQ 420
M R +V G +YA+GG G+ ++VE+Y + +W V+P+
Sbjct: 367 TSLERMNESRSTLGVVVLAGELYALGG--YDGQSYLQSVEKYIPKIRKWQPVAPMTTTRS 424
Query: 421 WSAAVVVHDCIYVM------TLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYI 474
AA V+ IY + +N + Y P DSW +A R IF +
Sbjct: 425 CFAAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVV 484
Query: 475 GGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSL 534
GG ++G+ S ++E YD ++N+W + + R V A VI N L
Sbjct: 485 GG-----HNGVSHLS--------SIERYDPHQNQWTVCRPMKEPRTG---VGAAVIDNYL 528
Query: 535 CV---FMRETHLNERAKY 549
V ++LN KY
Sbjct: 529 YVVGGHSGSSYLNTVQKY 546
Score = 48.1 bits (113), Expect = 2e-05
Identities = 29/108 (26%), Positives = 54/108 (50%), Gaps = 9/108 (8%)
Query: 353 FDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMV 412
+D +++W M RI + G+I+ +GG + G + ++ERYD +++WT+
Sbjct: 452 YDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN--GVSHLSSIERYDPHQNQWTVC 509
Query: 413 SPLPCAWQWSAAVVVHDCIYVMT-------LNLMYCYFPRSDSWVEMA 453
P+ A V+ + +YV+ LN + Y P SD+W++ A
Sbjct: 510 RPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSA 557
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 183 bits (465), Expect = 4e-46
Identities = 131/510 (25%), Positives = 221/510 (43%), Gaps = 48/510 (9%)
Query: 11 TEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQT 70
+ +A ++L+ F + +LFTD+++ VEG EFPCH+ VL+ CSSYFRAMF + ES++
Sbjct: 46 SSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREM 105
Query: 71 HVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINA 130
V + + A ++ + Y YTG + + V+ L+ET+ Q+ + C ++L ++++
Sbjct: 106 LVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDP 165
Query: 131 ENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEK 190
NC+ + FAD S + L K F V + F++L D LID + SD L + K
Sbjct: 166 CNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGK 225
Query: 191 EETVREAAMLWLEYNTESRSQYLSSVLSQIRIDAL------SEVTQRAWFQGLPPNDKSV 244
EE V EA M W+ + R L +L+ +R+ L V Q P + +
Sbjct: 226 EEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLL 285
Query: 245 VVQGLY-----KSMPKFFKPRLGMTKEEMMIFIEASSE-NPCSLYSSVCYSPQAEKVYKL 298
Y + M +PR E+++ + +L + CY P + L
Sbjct: 286 HEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSL 345
Query: 299 CSPPADLHKVGTVVTPDNDIYIAGGQV-------------------PLKNTKTNHSKTSK 339
P V NDI ++GG++ L + H
Sbjct: 346 AKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVL 405
Query: 340 L-----------QTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGD 388
L Q +V C +D+ N W P+ P++ C G ++ IGG
Sbjct: 406 LGKVYVVGGYDGQNRLSSVEC---YDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGG 462
Query: 389 SVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM--TLNLMYCYFPRS 446
+ + V+ YD E + W + + +P A + AV +++ IYV +YCY P
Sbjct: 463 PDDNTCSDK-VQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVE 521
Query: 447 DSWVEMAMRQTSRSFASAAAFGDKIFYIGG 476
D W+ + + + + KI+ +GG
Sbjct: 522 DYWMHVQNTFSRQENCGMSVCNGKIYILGG 551
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 28/156 (17%)
Query: 391 GGELNRRTVERYDTEKDEWTMVSPLPCA-WQWSAAVVVHDCIYVM-------TLNLMYCY 442
GG +N R V Y+++ + W V+ L W+ AV++ +YV+ L+ + CY
Sbjct: 369 GGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGK-VYVVGGYDGQNRLSSVECY 427
Query: 443 FPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGS-SVTVEI 501
S+ W E+A + + S + + K+F IGG G D + S V+
Sbjct: 428 DSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGG-------------GPDDNTCSDKVQS 474
Query: 502 YDVNKNEWKMAANIP-AKRYSDPCVRAVVISNSLCV 536
YD N W + A IP AKR C+ AV ++N + V
Sbjct: 475 YDPETNSWLLRAAIPIAKR----CITAVSLNNLIYV 506
Score = 32.0 bits (71), Expect = 1.7
Identities = 25/116 (21%), Positives = 44/116 (37%), Gaps = 2/116 (1%)
Query: 314 PDNDIYIAGGQVPL-KNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIK 372
P+ + ++ +P+ K T S + + A Y +D ++ W +
Sbjct: 477 PETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQEN 536
Query: 373 PSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVH 428
+ C G IY +GG GE T+ YD T V+ +P + V +H
Sbjct: 537 CGMSVCNGKIYILGGRRENGEAT-DTILCYDPATSIITGVAAMPRPVSYHGCVTIH 591
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 181 bits (460), Expect = 1e-45
Identities = 136/528 (25%), Positives = 231/528 (43%), Gaps = 53/528 (10%)
Query: 13 YAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHV 72
+A S+L + + D+ L VE +FP H++VLA CS YF AMF S LSE + +V
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 73 HLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAEN 132
++ + A+T++I++ + YT + + V++L AC LQ++ V Q C E+L +++ N
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 133 CVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEE 192
C+ + FA+ +C +L Q+A+ + F V + F+ LS + ++ D + V+ EE
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
Query: 193 TVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKS 252
V EA + W+++ + R + L ++L +R+ L+ P S+ + L
Sbjct: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
Query: 253 MPKFF--------------KPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKL 298
KF + RLG + +++ S ++P + Y P+ ++ L
Sbjct: 255 AKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEK--YDPKTQEWSFL 312
Query: 299 CSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQN 358
S V +V D IY+ GG + S+L +V C + +
Sbjct: 313 PSITRKRRYVASVSLHDR-IYVIGG----------YDGRSRLS----SVECLDYTADEDG 357
Query: 359 TWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCA 418
W+ PM R IY GG G ++ERYD D+W+M+ + A
Sbjct: 358 VWYSVAPMNVRRGLAGATTLGDMIYVSGG--FDGSRRHTSMERYDPNIDQWSMLGDMQTA 415
Query: 419 WQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKI 471
+ + VV IY + LN + Y P + W + T RS A A D I
Sbjct: 416 REGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHI 475
Query: 472 FYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKR 519
+ +GG GT SS VE Y++ + W ++ R
Sbjct: 476 YVVGGF-----------DGTAHLSS--VEAYNIRTDSWTTVTSMTTPR 510
Score = 47.4 bits (111), Expect = 4e-05
Identities = 32/125 (25%), Positives = 49/125 (39%), Gaps = 9/125 (7%)
Query: 353 FDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMV 412
+D W TPM R + +IY +GG G + +VE Y+ D WT V
Sbjct: 446 YDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG--FDGTAHLSSVEAYNIRTDSWTTV 503
Query: 413 SPLPCAWQWSAAVVVHDCIYVMT-------LNLMYCYFPRSDSWVEMAMRQTSRSFASAA 465
+ + + A V+ +Y + L+ + CY P DSW + T R A
Sbjct: 504 TSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVC 563
Query: 466 AFGDK 470
+K
Sbjct: 564 VLREK 568
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 179 bits (455), Expect = 5e-45
Identities = 144/569 (25%), Positives = 243/569 (42%), Gaps = 85/569 (14%)
Query: 26 EQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQII 85
+Q+ D++L+V+ + P H++VLA S +F MF + + ESK V L++ + ++ +
Sbjct: 39 KQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQL 98
Query: 86 ITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSC 145
+ +AYT +++N + V+ L + A Q+E V + C ++L ++++A NC+ + A+ C
Sbjct: 99 VEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDC 158
Query: 146 EELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYN 205
ELK +A + FT VY D F+QL + +L+ D L V E+ V +AA+ WL+Y+
Sbjct: 159 PELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYD 218
Query: 206 TESRSQYLSSVLSQIRIDALSEVTQRAWFQGLP-----PNDKSVVVQGL---------YK 251
+R ++ +L+++R +S+ Q P P +V+ G+ +
Sbjct: 219 EPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDRE 278
Query: 252 SMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTV 311
+ +PR + +F S C ++ YS + P + +
Sbjct: 279 ELVDGTRPRRKKHDYRIALF-GGSQPQSCRYFNPKDYS------WTDIRCPFEKRRDAAC 331
Query: 312 VTPDNDIYIAGGQ--VPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWF----PKTP 365
V DN +YI GG P+K ++C ++ +++W+ P TP
Sbjct: 332 VFWDNVVYILGGSQLFPIKR-----------------MDC---YNVVKDSWYSKLGPPTP 371
Query: 366 MLFVRIKPSLVCC--EGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSA 423
+ SL C EG IY GG VG E YDT + W +
Sbjct: 372 ------RDSLAACAAEGKIYTSGGSEVGNSA-LYLFECYDTRTESWHTKPSMLTQRCSHG 424
Query: 424 AVVVHDCIYV-----------MTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIF 472
V + IYV LN Y P +++W E+ +R DKIF
Sbjct: 425 MVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIF 484
Query: 473 YIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISN 532
+GG +G+ G VE YD+ NEWKM + +P K + C I
Sbjct: 485 AVGG-----QNGL--------GGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVY 531
Query: 533 SLCVFMRETHLNERAKYVTYQYDLELDRW 561
L F L +Y+ E D+W
Sbjct: 532 VLAGFQGVGRLGH-----ILEYNTETDKW 555
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 178 bits (452), Expect = 1e-44
Identities = 145/588 (24%), Positives = 245/588 (41%), Gaps = 111/588 (18%)
Query: 2 STQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFM 61
S+ +E +A +++ + +QQ D++LIV + P H++VL++ S YF AMF
Sbjct: 183 SSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFT 242
Query: 62 SGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCR 121
S + E+KQ + + +D L ++ +AYTG L + + T+E L AC LQ+ V++ C
Sbjct: 243 SDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCC 302
Query: 122 EYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDIL 181
+L+K ++ NC+ + +FAD C EL + A V F+ L + L +L
Sbjct: 303 HFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLL 362
Query: 182 SSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRI-----DALSEVTQRAWFQG 236
+SD++NV EET+ A M+W++Y+ +SR LS +L+ IR+ L+++ A F+
Sbjct: 363 ASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALFKN 422
Query: 237 LPPNDKSVVVQGLYKSMPK--------FFKPR---------------------------- 260
K ++ Y +P+ KPR
Sbjct: 423 DLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLR 482
Query: 261 ----------------LGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPAD 304
G+ + +F+ + +L + CY+P+ + L PP
Sbjct: 483 TNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVL--PPMS 540
Query: 305 LHKVGTVVTP-DNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPK 363
H+ G VT + IY GG H S L T R +D Q W
Sbjct: 541 THRHGLGVTVLEGPIYAVGG----------HDGWSYLNTVER-------WDPQSQQWTFV 583
Query: 364 TPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSA 423
M R + G +Y++GG G ++E YD ++W M +P+ C +
Sbjct: 584 ASMSIARSTVGVAALNGKLYSVGGRD--GSSCLSSMEYYDPHTNKWNMCAPM-CKRRGGV 640
Query: 424 AVVVHD-CIYVM-------------TLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGD 469
V D +Y + L+ + Y P++D+W +A R GD
Sbjct: 641 GVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGD 700
Query: 470 KIFYIGGLHIATNSGIRLPSGTVDGSSV--TVEIYDVNKNEWKMAANI 515
+++ +GG DG + T+E YD NEW A++
Sbjct: 701 RLYAVGG---------------YDGQTYLNTMESYDPQTNEWTQMASL 733
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/146 (24%), Positives = 58/146 (39%), Gaps = 14/146 (9%)
Query: 282 LYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQ 341
L S Y P K + +C+P V T D +Y GG +NH
Sbjct: 614 LSSMEYYDPHTNK-WNMCAPMCKRRGGVGVATCDGFLYAVGGH---DAPASNHCS----- 664
Query: 342 TAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVER 401
R ++ +D + +TW P+ R + +YA+GG G+ T+E
Sbjct: 665 ---RLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG--YDGQTYLNTMES 719
Query: 402 YDTEKDEWTMVSPLPCAWQWSAAVVV 427
YD + +EWT ++ L + VV+
Sbjct: 720 YDPQTNEWTQMASLNIGRAGACVVVI 745
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 177 bits (450), Expect = 2e-44
Identities = 143/563 (25%), Positives = 240/563 (42%), Gaps = 85/563 (15%)
Query: 32 DIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 91
D++L+V+ + P H++VLA S +F MF + + ESK V L++ + ++ ++ +AYT
Sbjct: 23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYT 82
Query: 92 GNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQS 151
+++N + V+ L + A Q+E V + C ++L ++++A NC+ + A+ C ELK +
Sbjct: 83 ARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKAT 142
Query: 152 AKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 211
A + FT VY D F+QL + +L+ D L V E+ V +AA+ WL+Y+ +R
Sbjct: 143 ADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQP 202
Query: 212 YLSSVLSQIRIDALSEVTQRAWFQGLP-----PNDKSVVVQGL---------YKSMPKFF 257
++ +L+++R +S+ Q P P +V+ G+ + +
Sbjct: 203 FMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGT 262
Query: 258 KPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDND 317
+PR + +F S C ++ YS + P + + V DN
Sbjct: 263 RPRRKKHDYRIALF-GGSQPQSCRYFNPKDYS------WTDIRCPFEKRRDAACVFWDNV 315
Query: 318 IYIAGGQ--VPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWF----PKTPMLFVRI 371
+YI GG P+K ++C ++ +++W+ P TP
Sbjct: 316 VYILGGSQLFPIKR-----------------MDC---YNVVKDSWYSKLGPPTP------ 349
Query: 372 KPSLVCC--EGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHD 429
+ SL C EG IY GG VG E YDT + W + V +
Sbjct: 350 RDSLAACAAEGKIYTSGGSEVGNSA-LYLFECYDTRTESWHTKPSMLTQRCSHGMVEANG 408
Query: 430 CIYV-----------MTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLH 478
IYV LN Y P +++W E+ +R DKIF +GG
Sbjct: 409 LIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGG-- 466
Query: 479 IATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFM 538
+G+ G VE YD+ NEWKM + +P K + C I L F
Sbjct: 467 ---QNGL--------GGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQ 515
Query: 539 RETHLNERAKYVTYQYDLELDRW 561
L +Y+ E D+W
Sbjct: 516 GVGRLGH-----ILEYNTETDKW 533
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 177 bits (449), Expect = 3e-44
Identities = 127/492 (25%), Positives = 226/492 (45%), Gaps = 49/492 (9%)
Query: 17 LLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQ-----TH 71
+L++L + FTD+ ++VEG EF H+ VLA+CS YF+ + + +S Q
Sbjct: 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLE 374
Query: 72 VHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 131
+ L N+ A L++++ + YTG+L ++ + + L E A Q + C +L K++ A
Sbjct: 375 LVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
Query: 132 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKE 191
NC+ +L+ A+ C EL AK F V Q+ + +S D I +S+D+LN + E
Sbjct: 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAE 494
Query: 192 ETVREAAMLWLEYNTESRSQYLSSVLSQIRID------ALSEVTQRAWFQGLPPNDKSVV 245
E V E + W++ + +R+QY + +L+ +R+ L+ V + V
Sbjct: 495 ELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVN 554
Query: 246 VQGLYKSMPKF--------FKPRLGMTKEEMMIFI---EASSENPCSLYSSVCYSPQAEK 294
Y +P +PRL E+++ + + SL + C++PQ K
Sbjct: 555 EAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNK 614
Query: 295 VYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFD 354
Y L S P + +VV+ ++IY++GG +++ + + +
Sbjct: 615 WYPLASLPFYDREFFSVVSAGDNIYLSGG----------------MESGVTLADVWCYMS 658
Query: 355 AQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSP 414
N W + M R + + + +G IY +GG V G ++ VERYDT ++W V+P
Sbjct: 659 LLDN-WNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDH--VERYDTITNQWEAVAP 715
Query: 415 LPCAWQWSAAVVVHDCIYVM--------TLNLMYCYFPRSDSWVEMAMRQTSRSFASAAA 466
LP A +AA V IYV ++ Y P++++W + +A A
Sbjct: 716 LPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVT 775
Query: 467 FGDKIFYIGGLH 478
+F +GG +
Sbjct: 776 LNGFVFILGGAY 787
Score = 45.4 bits (106), Expect = 2e-04
Identities = 50/193 (25%), Positives = 83/193 (43%), Gaps = 31/193 (16%)
Query: 382 IYAIGGDSVGGELNRR--TVERYDTEKDEWTMVSPLPCA-WQWSAAVVVHDCIYV----- 433
I +GG + G R V ++ + ++W ++ LP ++ + V D IY+
Sbjct: 586 IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME 645
Query: 434 --MTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGT 491
+TL ++CY D+W ++ R ++ + KI+ +GGL +A G
Sbjct: 646 SGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVA---------GN 696
Query: 492 VDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNE--RAKY 549
VD VE YD N+W+ A +P +S A V + VF +NE RA
Sbjct: 697 VD----HVERYDTITNQWEAVAPLPKAVHS---AAATVCGGKIYVF---GGVNEAGRAAG 746
Query: 550 VTYQYDLELDRWS 562
V Y + + WS
Sbjct: 747 VLQSYVPQTNTWS 759
Score = 30.8 bits (68), Expect = 3.9
Identities = 20/62 (32%), Positives = 29/62 (46%), Gaps = 10/62 (16%)
Query: 374 SLVCCEGYIYAIGG--DSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCI 431
S V +G IYA GG S G L +E Y+ + WT++ +PC V H C+
Sbjct: 815 SAVVLDGKIYATGGIVSSEGPALGN--MEAYEPTTNTWTLLPHMPC------PVFRHGCV 866
Query: 432 YV 433
+
Sbjct: 867 VI 868
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 177 bits (449), Expect = 3e-44
Identities = 127/492 (25%), Positives = 226/492 (45%), Gaps = 49/492 (9%)
Query: 17 LLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQ-----TH 71
+L++L + FTD+ ++VEG EF H+ VLA+CS YF+ + + +S Q
Sbjct: 315 MLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLE 374
Query: 72 VHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 131
+ L N+ A L++++ + YTG+L ++ + + L E A Q + C +L K++ A
Sbjct: 375 LVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTAS 434
Query: 132 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKE 191
NC+ +L+ A+ C EL AK F V Q+ + +S D I +S+D+LN + E
Sbjct: 435 NCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAE 494
Query: 192 ETVREAAMLWLEYNTESRSQYLSSVLSQIRID------ALSEVTQRAWFQGLPPNDKSVV 245
E V E + W++ + +R+QY + +L+ +R+ L+ V + V
Sbjct: 495 ELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVN 554
Query: 246 VQGLYKSMPKF--------FKPRLGMTKEEMMIFI---EASSENPCSLYSSVCYSPQAEK 294
Y +P +PRL E+++ + + SL + C++PQ K
Sbjct: 555 EAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNK 614
Query: 295 VYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFD 354
Y L S P + +VV+ ++IY++GG +++ + + +
Sbjct: 615 WYPLASLPFYDREFFSVVSAGDNIYLSGG----------------MESGVTLADVWCYMS 658
Query: 355 AQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSP 414
N W + M R + + + +G IY +GG V G ++ VERYDT ++W V+P
Sbjct: 659 LLDN-WNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDH--VERYDTITNQWEAVAP 715
Query: 415 LPCAWQWSAAVVVHDCIYVM--------TLNLMYCYFPRSDSWVEMAMRQTSRSFASAAA 466
LP A +AA V IYV ++ Y P++++W + +A A
Sbjct: 716 LPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVT 775
Query: 467 FGDKIFYIGGLH 478
+F +GG +
Sbjct: 776 LNGFVFILGGAY 787
Score = 45.4 bits (106), Expect = 2e-04
Identities = 50/193 (25%), Positives = 83/193 (43%), Gaps = 31/193 (16%)
Query: 382 IYAIGGDSVGGELNRR--TVERYDTEKDEWTMVSPLPCA-WQWSAAVVVHDCIYV----- 433
I +GG + G R V ++ + ++W ++ LP ++ + V D IY+
Sbjct: 586 IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGME 645
Query: 434 --MTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGT 491
+TL ++CY D+W ++ R ++ + KI+ +GGL +A G
Sbjct: 646 SGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVA---------GN 696
Query: 492 VDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNE--RAKY 549
VD VE YD N+W+ A +P +S A V + VF +NE RA
Sbjct: 697 VD----HVERYDTITNQWEAVAPLPKAVHS---AAATVCGGKIYVF---GGVNEAGRAAG 746
Query: 550 VTYQYDLELDRWS 562
V Y + + WS
Sbjct: 747 VLQSYVPQTNTWS 759
Score = 30.8 bits (68), Expect = 3.9
Identities = 20/62 (32%), Positives = 29/62 (46%), Gaps = 10/62 (16%)
Query: 374 SLVCCEGYIYAIGG--DSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCI 431
S V +G IYA GG S G L +E Y+ + WT++ +PC V H C+
Sbjct: 815 SAVVLDGKIYATGGIVSSEGPALGN--MEAYEPTTNTWTLLPHMPC------PVFRHGCV 866
Query: 432 YV 433
+
Sbjct: 867 VI 868
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 176 bits (447), Expect = 4e-44
Identities = 154/604 (25%), Positives = 253/604 (41%), Gaps = 64/604 (10%)
Query: 2 STQDERQINT-EYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMF 60
+T+ E Q + +A L +++ + +++ D++LI P H++VL+ S YF AMF
Sbjct: 152 ATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMF 211
Query: 61 MSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRC 120
+ + E+KQ V + VD L ++ YAYTG L + + T+E L AC LQ+ V+ C
Sbjct: 212 TNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVC 271
Query: 121 REYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDI 180
+LIK+++ NC+ + SF D C EL A + F V F+ L + + +
Sbjct: 272 SNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKL 331
Query: 181 LSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRI-----DALSEVTQRAWFQ 235
L SD++NV EET+ A M W+ ++ ++R L +LS IR+ L+++ + F
Sbjct: 332 LCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFT 391
Query: 236 GLPPNDKSVVVQGLYKSMPK----FFKPRLGMTKEEMMIFIEASSENPCSLYSSV-CYSP 290
G K ++ Y +P+ PR K + + +++ Y
Sbjct: 392 GDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDL 451
Query: 291 QAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCF 350
+ + + + G V DN +Y+ GG+ LK TV C
Sbjct: 452 RTNSWLHIGTMNGRRLQFGVAVI-DNKLYVVGGRDGLK--------------TLNTVEC- 495
Query: 351 YWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWT 410
F+ W PM R + EG +YA+GG LN TVER+D E +W
Sbjct: 496 --FNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLN--TVERWDPEGRQWN 551
Query: 411 MVSPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQTSRSFAS 463
V+ + V +++ +Y + L M + P ++ W A R
Sbjct: 552 YVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVG 611
Query: 464 AAAFGDKIFYIGGLHI-ATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSD 522
A + ++ +GG A+N RL S VE YD + W A + R
Sbjct: 612 VATYNGFLYVVGGHDAPASNHCSRL--------SDCVERYDPKGDSWSTVAPLSVPR--- 660
Query: 523 PCVRAVVISNSLCV---FMRETHLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDF 579
V + + L V + T+LN YD + + W E V ++GR
Sbjct: 661 DAVAVCPLGDKLYVVGGYDGHTYLN-----TVESYDAQRNEW------KEEVPVNIGRAG 709
Query: 580 RCTV 583
C V
Sbjct: 710 ACVV 713
Score = 41.2 bits (95), Expect = 0.003
Identities = 35/146 (23%), Positives = 58/146 (39%), Gaps = 14/146 (9%)
Query: 282 LYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQ 341
L S + P K + LC+P + V T + +Y+ GG +NH
Sbjct: 584 LKSMEYFDPHTNK-WSLCAPMSKRRGGVGVATYNGFLYVVGGH---DAPASNHCS----- 634
Query: 342 TAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVER 401
R +C +D + ++W P+ R ++ +Y +GG G TVE
Sbjct: 635 ---RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG--YDGHTYLNTVES 689
Query: 402 YDTEKDEWTMVSPLPCAWQWSAAVVV 427
YD +++EW P+ + VVV
Sbjct: 690 YDAQRNEWKEEVPVNIGRAGACVVVV 715
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 176 bits (447), Expect = 4e-44
Identities = 143/580 (24%), Positives = 260/580 (44%), Gaps = 81/580 (13%)
Query: 10 NTEYAVSLLEQLKLFYEQQLFTDIVL-IVEGTEFPCHKMVLATCSSYFRAMFMSGLSESK 68
++ + V L+ + FY LFTDI L G F CH+ VLA CS+YF+AMF + + E
Sbjct: 15 DSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKF 74
Query: 69 QTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKI 128
+ + L + L+ ++ YAYT + + V+ L E A LQ V + C +L++ +
Sbjct: 75 KNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHL 134
Query: 129 NAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNV 188
+ +NC+ + SFA+ C EL++ ++R++ KF V+ Q+ F+++S + + ILS NL+V
Sbjct: 135 DIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKNLSV 194
Query: 189 EKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPN---DKSVV 245
KEE + E + W ++ E+R + L ++LS I ID + A GL + ++ +
Sbjct: 195 WKEEAIIEPVIKWTAHDVENRIECLYNLLSYINIDIDPVYLKTA--LGLQRSCLLTENKI 252
Query: 246 VQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADL 305
+Y ++ K E S + ++Y Y P +++
Sbjct: 253 RSLIYNALNPMHK--------------EISQRSTATMYIIGGY---------YWHPLSEV 289
Query: 306 HKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTS-----KLQTAFRTVN-----CFYWFDA 355
H + P +++I G ++P T+ ++ T + +RT N + +++
Sbjct: 290 H----IWDPLTNVWIQGAEIP-DYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNS 344
Query: 356 QQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPL 415
+ + W PML R V G +YA+GG G E YD K++W ++ +
Sbjct: 345 ESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEE--AEFYDPLKEKWIPIANM 402
Query: 416 PCAWQWSAAVVVHDCIYVM----------TLNLMYCYFPRSDSWVEMAMRQTSRSFASAA 465
+ A V+HD IYV+ T + + Y + W + +
Sbjct: 403 IKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSV 462
Query: 466 AFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCV 525
F +K++ +G G + E YD +NEW+ A + +R C
Sbjct: 463 PFENKLYLVG------------------GQTTITECYDPEQNEWREIAPMMERRME--C- 501
Query: 526 RAVVISNSLCVFMRETHLNERAKYV--TYQYDLELDRWSL 563
VI N C+++ + + Y+ +YD +L++W +
Sbjct: 502 -GAVIMNG-CIYVTGGYSYSKGTYLQSIEKYDPDLNKWEI 539
Score = 52.0 bits (123), Expect = 2e-06
Identities = 38/147 (25%), Positives = 60/147 (40%), Gaps = 35/147 (23%)
Query: 283 YSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQT 342
+S + SP E Y LCS P + N +Y+ GGQ +
Sbjct: 446 WSLITSSPHPE--YGLCSVPFE-----------NKLYLVGGQTTITEC------------ 480
Query: 343 AFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERY 402
+D +QN W PM+ R++ V G IY GG S +++E+Y
Sbjct: 481 ----------YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKY 530
Query: 403 DTEKDEWTMVSPLPCAWQWSAAVVVHD 429
D + ++W +V LP A + V V++
Sbjct: 531 DPDLNKWEIVGNLPSAMRSHGCVCVYN 557
>gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 176 bits (445), Expect = 7e-44
Identities = 129/474 (27%), Positives = 219/474 (46%), Gaps = 44/474 (9%)
Query: 9 INTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESK 68
++ ++ +L L+ F EQ +F D +I++ PCH+ VLA CS +FRAMF + E
Sbjct: 30 VSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERD 89
Query: 69 QTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKI 128
V + N+ + ++ + YAYTG + D VE ++ + FLQV + + C ++LIK I
Sbjct: 90 DGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSI 149
Query: 129 NAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNV 188
N NC++LLS +D + L A V+H F+ ++ F++++ +L L SD LNV
Sbjct: 150 NLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNV 209
Query: 189 EKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQG 248
+EE V + + W ++N ESR +YL ++ ++R+ LSE T + KS
Sbjct: 210 PEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFD 269
Query: 249 LYKSMPKFFKPRLGM------TKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPP 302
+ K + G+ + E IFI + EN + Y + CY+ +++ +K+
Sbjct: 270 IIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQY-TFCYNIKSDS-WKILPQS 327
Query: 303 ADLHKVGTVVTPDND-IYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTW- 360
+ G+ ++ + I++ GG K +T +L A + DA TW
Sbjct: 328 HLIDLPGSSLSSYGEKIFLTGG------CKGKCCRTVRLHIAES------YHDATDQTWC 375
Query: 361 --------FPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGE--LNRRTVERYDTEKDEWT 410
F + M R + V ++ IGG + G + VE Y+ EW
Sbjct: 376 YCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWI 435
Query: 411 MVSPLPCAWQWSAAVVVHDCIYVM------------TLNLMYCYFPRSDSWVEM 452
VSPLP + A + IYV+ +L+ + Y +D W E+
Sbjct: 436 SVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSEL 489
Score = 31.6 bits (70), Expect = 2.3
Identities = 33/152 (21%), Positives = 61/152 (40%), Gaps = 22/152 (14%)
Query: 440 YCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTV 499
+CY P + + ++ +T R+ ++ D++F IGG G R +D V
Sbjct: 374 WCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGG----KTRGSRDIKSLLD-----V 424
Query: 500 EIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNER---AKYVTYQYDL 556
E Y+ EW + +P Y A N + V E + + + ++Y+
Sbjct: 425 ESYNPLSKEWISVSPLPRGIYYP---EASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNA 481
Query: 557 ELDRWSLRQHISERVLWDLGRDFRCTVGKLYP 588
D+WS ++ + G+ F T+ K P
Sbjct: 482 TTDQWS-------ELVAEFGQFFHATLIKAVP 506
Score = 31.6 bits (70), Expect = 2.3
Identities = 16/40 (40%), Positives = 22/40 (55%), Gaps = 1/40 (2%)
Query: 379 EGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCA 418
E IY +GGD E+ V+ Y + + EW VSP+P A
Sbjct: 550 EDKIYILGGDYAPDEITDE-VQVYHSNRSEWEEVSPMPRA 588
>gi|38327516 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 176 bits (445), Expect = 7e-44
Identities = 129/474 (27%), Positives = 219/474 (46%), Gaps = 44/474 (9%)
Query: 9 INTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESK 68
++ ++ +L L+ F EQ +F D +I++ PCH+ VLA CS +FRAMF + E
Sbjct: 30 VSEDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVNMKERD 89
Query: 69 QTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKI 128
V + N+ + ++ + YAYTG + D VE ++ + FLQV + + C ++LIK I
Sbjct: 90 DGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSI 149
Query: 129 NAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNV 188
N NC++LLS +D + L A V+H F+ ++ F++++ +L L SD LNV
Sbjct: 150 NLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLLFKSSDFLEMNFGVLQKCLESDELNV 209
Query: 189 EKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQG 248
+EE V + + W ++N ESR +YL ++ ++R+ LSE T + KS
Sbjct: 210 PEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEESLLKSTNCFD 269
Query: 249 LYKSMPKFFKPRLGM------TKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPP 302
+ K + G+ + E IFI + EN + Y + CY+ +++ +K+
Sbjct: 270 IIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGENQY-TFCYNIKSDS-WKILPQS 327
Query: 303 ADLHKVGTVVTPDND-IYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTW- 360
+ G+ ++ + I++ GG K +T +L A + DA TW
Sbjct: 328 HLIDLPGSSLSSYGEKIFLTGG------CKGKCCRTVRLHIAES------YHDATDQTWC 375
Query: 361 --------FPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGE--LNRRTVERYDTEKDEWT 410
F + M R + V ++ IGG + G + VE Y+ EW
Sbjct: 376 YCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVESYNPLSKEWI 435
Query: 411 MVSPLPCAWQWSAAVVVHDCIYVM------------TLNLMYCYFPRSDSWVEM 452
VSPLP + A + IYV+ +L+ + Y +D W E+
Sbjct: 436 SVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQWSEL 489
Score = 31.6 bits (70), Expect = 2.3
Identities = 33/152 (21%), Positives = 61/152 (40%), Gaps = 22/152 (14%)
Query: 440 YCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTV 499
+CY P + + ++ +T R+ ++ D++F IGG G R +D V
Sbjct: 374 WCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGG----KTRGSRDIKSLLD-----V 424
Query: 500 EIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNER---AKYVTYQYDL 556
E Y+ EW + +P Y A N + V E + + + ++Y+
Sbjct: 425 ESYNPLSKEWISVSPLPRGIYYP---EASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNA 481
Query: 557 ELDRWSLRQHISERVLWDLGRDFRCTVGKLYP 588
D+WS ++ + G+ F T+ K P
Sbjct: 482 TTDQWS-------ELVAEFGQFFHATLIKAVP 506
Score = 31.6 bits (70), Expect = 2.3
Identities = 16/40 (40%), Positives = 22/40 (55%), Gaps = 1/40 (2%)
Query: 379 EGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCA 418
E IY +GGD E+ V+ Y + + EW VSP+P A
Sbjct: 550 EDKIYILGGDYAPDEITDE-VQVYHSNRSEWEEVSPMPRA 588
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 175 bits (444), Expect = 1e-43
Identities = 148/597 (24%), Positives = 249/597 (41%), Gaps = 101/597 (16%)
Query: 11 TEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQT 70
+ YA S+L L L +Q+LFTD++L FPCH+ VLA CS YF AMF GL ES+ +
Sbjct: 26 SSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDS 85
Query: 71 HVHLRN-VDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKIN 129
V+ N + L++++ YAY+ + +N+ E L E L+ +D+ C E+L K ++
Sbjct: 86 EVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLH 145
Query: 130 AENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVE 189
NC+ +L +D C +L + + RM F + + F+QL D+++ +LSS+ L E
Sbjct: 146 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETE 205
Query: 190 KEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGL 249
E V E+A+ W+ Y+ + R YL +L +R+ L + ++V ++ L
Sbjct: 206 DERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLM----------ENVAMEEL 255
Query: 250 YKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQ---------------AEK 294
K R E I + + +S+C P+ +K
Sbjct: 256 ------ITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDK 309
Query: 295 VYKLCSPPADLHKVGTVVTPDND---------IYIAGGQVPLKNTKTNHSKTSKLQTAFR 345
+Y + ++ + +P + +YI GG + ++ SK
Sbjct: 310 LYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGG----RGSENGVSKD-------- 357
Query: 346 TVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDS-------VGGELNRRT 398
+ +D W PML R + +Y +GG + ++ +
Sbjct: 358 ----VWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQ 413
Query: 399 VERYDTEKDEWTMVSPLPCAWQWSAAV-------------VVHDCIYVMTLNLMYCYFPR 445
VE YD ++WTMV+PL +A V V HD L + CY
Sbjct: 414 VEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHD-----KLPKVQCYDQC 468
Query: 446 SDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVN 505
+ W A + +AA G++IF +G G + S+ + ++
Sbjct: 469 ENRWTVPATCPQPWRYTAAAVLGNQIFIMG--------------GDTEFSACSAYKFNSE 514
Query: 506 KNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWS 562
+W ++ AKR S AV N L V + +R K + YD LD W+
Sbjct: 515 TYQWTKVGDVTAKRMS---CHAVASGNKLYVVGGYFGI-QRCKTLDC-YDPTLDVWN 566
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/170 (22%), Positives = 73/170 (42%), Gaps = 20/170 (11%)
Query: 353 FDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMV 412
+D N W P+ ++V + ++A GG SV + + V+ YD ++ WT+
Sbjct: 417 YDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPK-VQCYDQCENRWTVP 475
Query: 413 SPLPCAWQWSAAVVVHDCIYVM------TLNLMYCYFPRSDSWVEMAMRQTSRSFASAAA 466
+ P W+++AA V+ + I++M + Y + + W ++ R A A
Sbjct: 476 ATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVA 535
Query: 467 FGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIP 516
G+K++ +GG GI+ T++ YD + W +P
Sbjct: 536 SGNKLYVVGGYF-----GIQ--------RCKTLDCYDPTLDVWNSITTVP 572
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 175 bits (444), Expect = 1e-43
Identities = 131/534 (24%), Positives = 231/534 (43%), Gaps = 44/534 (8%)
Query: 3 TQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMS 62
T DE +A ++++ + + D++L+ P H++VL++ S YF AMF +
Sbjct: 146 TSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTN 205
Query: 63 GLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCRE 122
+ E++Q + + V+ +L +I YAYTG L + + +E L TAC LQ+ V++ C +
Sbjct: 206 DVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCK 265
Query: 123 YLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILS 182
+L+K+++ NC+ + SFAD C +L + A F V F+ L + +L+
Sbjct: 266 FLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLA 325
Query: 183 SDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRI-----DALSEVTQRAWFQGL 237
SD++N+ EET+ A + W+ ++ E R + LS +L+ IR+ L+++ F+
Sbjct: 326 SDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDD 385
Query: 238 PPNDKSVVVQGLYKSMPK----FFKPRLGMTKEEM-MIFIEASSENPCSLYSSVCYSPQA 292
K ++ Y +P+ PR K + +F ++ S Y +
Sbjct: 386 IECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRT 445
Query: 293 EKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYW 352
+ + + G V D+ +Y+ GG+ LK TV C
Sbjct: 446 NMWTPVANMNGRRLQFGVAVL-DDKLYVVGGRDGLK--------------TLNTVEC--- 487
Query: 353 FDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMV 412
++ + TW PM R + EG +YA+GG LN TVER+D + +W V
Sbjct: 488 YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLN--TVERWDPQARQWNFV 545
Query: 413 SPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQTSRSFASAA 465
+ + V+ +Y + L + C+ P ++ W A R
Sbjct: 546 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 605
Query: 466 AFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKR 519
+ ++ IGG H A S + S VE YD + W A++ R
Sbjct: 606 TWNGLLYAIGG-HDAPASNL------TSRLSDCVERYDPKTDMWTAVASMSISR 652
Score = 46.6 bits (109), Expect = 7e-05
Identities = 42/146 (28%), Positives = 61/146 (41%), Gaps = 17/146 (11%)
Query: 282 LYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQ-VPLKNTKTNHSKTSKL 340
L S C+ P K + LC+ + V T + +Y GG P N TS+L
Sbjct: 576 LKSVECFDPHTNK-WTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL------TSRL 628
Query: 341 QTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVE 400
+C +D + + W M R + +YA+GG G+ TVE
Sbjct: 629 S------DCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG--YDGQAYLNTVE 680
Query: 401 RYDTEKDEWTMVSPLPCAWQWSAAVV 426
YD + +EWT V+PL C + A VV
Sbjct: 681 AYDPQTNEWTQVAPL-CLGRAGACVV 705
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 175 bits (444), Expect = 1e-43
Identities = 131/534 (24%), Positives = 231/534 (43%), Gaps = 44/534 (8%)
Query: 3 TQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMS 62
T DE +A ++++ + + D++L+ P H++VL++ S YF AMF +
Sbjct: 192 TSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTN 251
Query: 63 GLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCRE 122
+ E++Q + + V+ +L +I YAYTG L + + +E L TAC LQ+ V++ C +
Sbjct: 252 DVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCK 311
Query: 123 YLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILS 182
+L+K+++ NC+ + SFAD C +L + A F V F+ L + +L+
Sbjct: 312 FLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLA 371
Query: 183 SDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRI-----DALSEVTQRAWFQGL 237
SD++N+ EET+ A + W+ ++ E R + LS +L+ IR+ L+++ F+
Sbjct: 372 SDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRDD 431
Query: 238 PPNDKSVVVQGLYKSMPK----FFKPRLGMTKEEM-MIFIEASSENPCSLYSSVCYSPQA 292
K ++ Y +P+ PR K + +F ++ S Y +
Sbjct: 432 IECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRT 491
Query: 293 EKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYW 352
+ + + G V D+ +Y+ GG+ LK TV C
Sbjct: 492 NMWTPVANMNGRRLQFGVAVL-DDKLYVVGGRDGLK--------------TLNTVEC--- 533
Query: 353 FDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMV 412
++ + TW PM R + EG +YA+GG LN TVER+D + +W V
Sbjct: 534 YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLN--TVERWDPQARQWNFV 591
Query: 413 SPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQTSRSFASAA 465
+ + V+ +Y + L + C+ P ++ W A R
Sbjct: 592 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 651
Query: 466 AFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKR 519
+ ++ IGG H A S + S VE YD + W A++ R
Sbjct: 652 TWNGLLYAIGG-HDAPASNL------TSRLSDCVERYDPKTDMWTAVASMSISR 698
Score = 46.6 bits (109), Expect = 7e-05
Identities = 42/146 (28%), Positives = 61/146 (41%), Gaps = 17/146 (11%)
Query: 282 LYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQ-VPLKNTKTNHSKTSKL 340
L S C+ P K + LC+ + V T + +Y GG P N TS+L
Sbjct: 622 LKSVECFDPHTNK-WTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL------TSRL 674
Query: 341 QTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVE 400
+C +D + + W M R + +YA+GG G+ TVE
Sbjct: 675 S------DCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG--YDGQAYLNTVE 726
Query: 401 RYDTEKDEWTMVSPLPCAWQWSAAVV 426
YD + +EWT V+PL C + A VV
Sbjct: 727 AYDPQTNEWTQVAPL-CLGRAGACVV 751
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 174 bits (440), Expect = 3e-43
Identities = 148/582 (25%), Positives = 245/582 (42%), Gaps = 58/582 (9%)
Query: 2 STQDERQINT-EYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMF 60
+T+ E Q + +A L +++ + +++ D++LI P H++VL+ S YF AMF
Sbjct: 152 ATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMF 211
Query: 61 MSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRC 120
+ + E+KQ V + VD L ++ YAYTG L + + T+E L AC LQ+ V+ C
Sbjct: 212 TNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVC 271
Query: 121 REYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDI 180
+LIK+++ NC+ + SF D C EL A + F V F+ L + + +
Sbjct: 272 SNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKL 331
Query: 181 LSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRI-----DALSEVTQRAWFQ 235
L SD++NV EET+ A M W+ ++ ++R L +LS IR+ L+++ + F
Sbjct: 332 LCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFT 391
Query: 236 GLPPNDKSVVVQGLYKSMPK----FFKPRLGMTKEEMMIFIEASSENPCSLYSSV-CYSP 290
G K ++ Y +P+ PR K + + +++ Y
Sbjct: 392 GDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDL 451
Query: 291 QAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCF 350
+ + + + G V DN +Y+ GG+ LK TV C
Sbjct: 452 RTNSWLHIGTMNGRRLQFGVAVI-DNKLYVVGGRDGLK--------------TLNTVEC- 495
Query: 351 YWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWT 410
F+ W PM R + EG +YA+GG LN TVER+D E +W
Sbjct: 496 --FNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLN--TVERWDPEGRQWN 551
Query: 411 MVSPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQTSRSFAS 463
V+ + V +++ +Y + L M + P ++ W A R
Sbjct: 552 YVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVG 611
Query: 464 AAAFGDKIFYIGGLHI-ATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSD 522
A + ++ +GG A+N RL S VE YD + W A + R
Sbjct: 612 VATYNGFLYVVGGHDAPASNHCSRL--------SDCVERYDPKGDSWSTVAPLSVPR--- 660
Query: 523 PCVRAVVISNSLCV---FMRETHLNERAKYVTYQYDLELDRW 561
V + + L V + T+LN YD + + W
Sbjct: 661 DAVAVCPLGDKLYVVGGYDGHTYLN-----TVESYDAQRNEW 697
Score = 48.9 bits (115), Expect = 1e-05
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 33/201 (16%)
Query: 380 GYIYAIGG-DSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM---- 434
G +YA+GG D++ G T+E+YD + W + + V+ + +YV+
Sbjct: 429 GALYAVGGMDAMKGTT---TIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRD 485
Query: 435 ---TLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGT 491
TLN + C+ P W M T R GL +AT G G
Sbjct: 486 GLKTLNTVECFNPVGKIWTVMPPMSTHRH---------------GLGVATLEGPMYAVGG 530
Query: 492 VDGSSV--TVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKY 549
DG S TVE +D +W A++ R + V V ++N L + K
Sbjct: 531 HDGWSYLNTVERWDPEGRQWNYVASMSTPRST---VGVVALNNKLYAIGGRDG-SSCLKS 586
Query: 550 VTYQYDLELDRWSLRQHISER 570
+ Y +D ++WSL +S+R
Sbjct: 587 MEY-FDPHTNKWSLCAPMSKR 606
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 174 bits (440), Expect = 3e-43
Identities = 134/477 (28%), Positives = 217/477 (45%), Gaps = 36/477 (7%)
Query: 17 LLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRN 76
+L+ L+ Q D+ L+V G E PCH+ +LA S YF AMF +ES V LR+
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
Query: 77 VDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRL 136
V+ A + ++ + YTG L + VE L TA L V + C YL ++++A NC+ +
Sbjct: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
Query: 137 LSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVRE 196
F + + A + F AV +D F+QL + L+ L+ D L V+ E++ E
Sbjct: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
Query: 197 AAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKF 256
A M W+ ++ ++R+ +L +LS + +DA+ + P +S +
Sbjct: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDG 240
Query: 257 FKPRLGMTKEEMMIFI--------EASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKV 308
L EE+++ + EA E L + Y+ +A++ L P D HK
Sbjct: 241 APLALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFP-DYHKW 299
Query: 309 G-TVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPML 367
G ++ +N+IY+ GG + TKT+ T++ + F ++ +W P PML
Sbjct: 300 GFSLAALNNNIYVTGGS---RGTKTDTWSTTQA----------WCFPLKEASWKPVAPML 346
Query: 368 FVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSP-LPCAWQWSAA-- 424
R + G IY IGG + L+ VE YD D WT VSP L +SAA
Sbjct: 347 KPRTNHASAALNGEIYVIGGTT----LDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGC 402
Query: 425 ----VVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFAS--AAAFGDKIFYIG 475
+V + CY P +D+W +A + +S AA +++ IG
Sbjct: 403 RGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIG 459
Score = 33.1 bits (74), Expect = 0.78
Identities = 23/78 (29%), Positives = 31/78 (39%), Gaps = 1/78 (1%)
Query: 351 YWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRT-VERYDTEKDEW 409
Y +D N W + +LV +Y GG G E + +E YDT +D W
Sbjct: 466 YVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTW 525
Query: 410 TMVSPLPCAWQWSAAVVV 427
T LP W + A V
Sbjct: 526 TRHGALPRLWLYHGASTV 543
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 172 bits (437), Expect = 6e-43
Identities = 143/593 (24%), Positives = 247/593 (41%), Gaps = 77/593 (12%)
Query: 12 EYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTH 71
+++ LL QL + ++ TD+ + E PCH+ VLA+ S YFRAMF S E +
Sbjct: 15 DFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAK 74
Query: 72 VHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 131
V L+ +D TL I++Y YTG + V + E A LQ + + C YL ++
Sbjct: 75 VQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPS 134
Query: 132 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKE 191
NC+ ++ +++ SCE LK+ A+ + F V +L L D L D L E E
Sbjct: 135 NCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGLCGE-E 193
Query: 192 ETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPND----KSVVVQ 247
E V EA M+W++++ ++R +Y+ + Q+R+ + A+F ND S Q
Sbjct: 194 EKVFEALMVWIKHDLQARKRYMQELFKQVRL----QYIHPAFFHHFIANDALLQSSPACQ 249
Query: 248 GLYKSMPKFFKPRLGMT---------------KEEMMIFIEASSENPCSLYSSVCYSPQA 292
+ ++ + G T ++ +I + ++ + + YS Q
Sbjct: 250 IILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQT 309
Query: 293 EKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQ-VPLKNTKTNHSKTSKLQTAFRTVNCFY 351
+ L P L+K + +T IY+ GG V + +H+ Y
Sbjct: 310 GQWQSLAKLPTRLYK-ASAITLHRSIYVLGGMAVSSGRSLVSHN--------------VY 354
Query: 352 WFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTM 411
F + N W PML R + +I++IGG G EL ++ERYD+ + W
Sbjct: 355 IFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQEL-MGSMERYDSICNVWES 413
Query: 412 VSPLPCAWQWSAAVVVHDCIYVM--------TLNLMYCYFPRSDSWVEMAMRQTSRSFAS 463
++ +P A V +Y+ + L+ Y +SW +M R A
Sbjct: 414 MASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAP 473
Query: 464 AAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDP 523
A G++I +GG + + YD N++ A++ +R
Sbjct: 474 AVVLGERIVIVGGY------------------TRRILAYDPQSNKFVKCADMKDRRMHH- 514
Query: 524 CVRAVVISNSLCV-----FMRETHLNERAKYVTYQYDLELDRWSLRQHISERV 571
A V+ N L V + ++ + A + YD E D W+ + + ++
Sbjct: 515 --GATVMGNKLYVTGGRRLTTDCNIEDSASFDC--YDPETDTWTSQGQLPHKL 563
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 169 bits (429), Expect = 5e-42
Identities = 139/543 (25%), Positives = 242/543 (44%), Gaps = 80/543 (14%)
Query: 10 NTEYAVSLLEQLKLFYEQQLFTDIVLIVE-----GTEFPCHKMVLATCSSYFRAMFMSGL 64
+T+ A ++ +L+L Q D+ L V+ +F HK+VLA+ S F+AMF +GL
Sbjct: 59 HTKQAFGIMNELRL---SQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGL 115
Query: 65 SESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYL 124
E V + + ++ +I +AYT +++M + V + A Q++ V++ C ++L
Sbjct: 116 REQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Query: 125 IKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSD 184
+++++ N + + +FA+ C EL Q A+ + F V Q+ F LSH L+ ++S D
Sbjct: 176 VQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRD 235
Query: 185 NLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSV 244
+LNV E V A + W++Y+ E R Y+ ++L +R +L+ + Q K
Sbjct: 236 DLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQ------KCE 289
Query: 245 VVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCS-------LYSSVCYSPQAEKVYK 297
++Q + K L EE+ + + + PC +Y++ Y Q+ +
Sbjct: 290 ILQSDSRC-----KDYLVKIFEELTLH-KPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLE 343
Query: 298 LCSPP-------ADLH-----KVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFR 345
+P ADL G VV +Y GG+ N+ ++ +S L
Sbjct: 344 AYNPSDGTWLRLADLQVPRSGLAGCVV--GGLLYAVGGR---NNSPDGNTDSSALDC--- 395
Query: 346 TVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTE 405
++ N W P PM R + + +G+IYA+GG G ++ +VERY+ E
Sbjct: 396 -------YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSVERYEPE 446
Query: 406 KDEWTMVSPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQTS 458
+DEW +V+P+ V++ +Y + LN CY+P + W + T
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI 506
Query: 459 RSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSV--TVEIYDVNKNEWKMAANIP 516
RS A + I+ GG DG +VE YDV W A +
Sbjct: 507 RSGAGVCVLHNCIYAAGG---------------YDGQDQLNSVERYDVETETWTFVAPMK 551
Query: 517 AKR 519
+R
Sbjct: 552 HRR 554
Score = 60.5 bits (145), Expect = 5e-09
Identities = 59/268 (22%), Positives = 104/268 (38%), Gaps = 57/268 (21%)
Query: 287 CYSPQAEKVYKLCSP---PADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTA 343
CY+P + + C+P P + VG + D IY GG + +H+ +
Sbjct: 395 CYNPMTNQ-WSPCAPMSVPRNRIGVGVI---DGHIYAVGGS----HGCIHHNSVER---- 442
Query: 344 FRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYD 403
++ +++ W PML RI + +YA+GG LN + E Y
Sbjct: 443 ---------YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLN--SAECYY 491
Query: 404 TEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQ 456
E++EW M++ + + V+H+CIY LN + Y +++W +A +
Sbjct: 492 PERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMK 551
Query: 457 TSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSV--TVEIYDVNKNEWKMAAN 514
RS +I+ +GG DG + +VE YD + + W
Sbjct: 552 HRRSALGITVHQGRIYVLGG---------------YDGHTFLDSVECYDPDTDTWSEVTR 596
Query: 515 IPAKRYS-------DPCVRAVVISNSLC 535
+ + R +PC + + N C
Sbjct: 597 MTSGRSGVGVAVTMEPCRKQIDQQNCTC 624
Score = 37.4 bits (85), Expect = 0.042
Identities = 34/153 (22%), Positives = 60/153 (39%), Gaps = 20/153 (13%)
Query: 261 LGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYI 320
+G+ +++ + L S+ CY P+ + +++ + + V N IY
Sbjct: 463 VGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNE-WRMITAMNTIRSGAGVCVLHNCIYA 521
Query: 321 AGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEG 380
AGG + +L + R +D + TW PM R + +G
Sbjct: 522 AGG----------YDGQDQLNSVER-------YDVETETWTFVAPMKHRRSALGITVHQG 564
Query: 381 YIYAIGGDSVGGELNRRTVERYDTEKDEWTMVS 413
IY +GG G +VE YD + D W+ V+
Sbjct: 565 RIYVLGG--YDGHTFLDSVECYDPDTDTWSEVT 595
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 169 bits (429), Expect = 5e-42
Identities = 139/543 (25%), Positives = 242/543 (44%), Gaps = 80/543 (14%)
Query: 10 NTEYAVSLLEQLKLFYEQQLFTDIVLIVE-----GTEFPCHKMVLATCSSYFRAMFMSGL 64
+T+ A ++ +L+L Q D+ L V+ +F HK+VLA+ S F+AMF +GL
Sbjct: 59 HTKQAFGIMNELRL---SQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGL 115
Query: 65 SESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYL 124
E V + + ++ +I +AYT +++M + V + A Q++ V++ C ++L
Sbjct: 116 REQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Query: 125 IKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSD 184
+++++ N + + +FA+ C EL Q A+ + F V Q+ F LSH L+ ++S D
Sbjct: 176 VQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRD 235
Query: 185 NLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSV 244
+LNV E V A + W++Y+ E R Y+ ++L +R +L+ + Q K
Sbjct: 236 DLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQ------KCE 289
Query: 245 VVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCS-------LYSSVCYSPQAEKVYK 297
++Q + K L EE+ + + + PC +Y++ Y Q+ +
Sbjct: 290 ILQSDSRC-----KDYLVKIFEELTLH-KPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLE 343
Query: 298 LCSPP-------ADLH-----KVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFR 345
+P ADL G VV +Y GG+ N+ ++ +S L
Sbjct: 344 AYNPSDGTWLRLADLQVPRSGLAGCVV--GGLLYAVGGR---NNSPDGNTDSSALDC--- 395
Query: 346 TVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTE 405
++ N W P PM R + + +G+IYA+GG G ++ +VERY+ E
Sbjct: 396 -------YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSVERYEPE 446
Query: 406 KDEWTMVSPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQTS 458
+DEW +V+P+ V++ +Y + LN CY+P + W + T
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI 506
Query: 459 RSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSV--TVEIYDVNKNEWKMAANIP 516
RS A + I+ GG DG +VE YDV W A +
Sbjct: 507 RSGAGVCVLHNCIYAAGG---------------YDGQDQLNSVERYDVETETWTFVAPMK 551
Query: 517 AKR 519
+R
Sbjct: 552 HRR 554
Score = 60.5 bits (145), Expect = 5e-09
Identities = 59/268 (22%), Positives = 104/268 (38%), Gaps = 57/268 (21%)
Query: 287 CYSPQAEKVYKLCSP---PADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTA 343
CY+P + + C+P P + VG + D IY GG + +H+ +
Sbjct: 395 CYNPMTNQ-WSPCAPMSVPRNRIGVGVI---DGHIYAVGGS----HGCIHHNSVER---- 442
Query: 344 FRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYD 403
++ +++ W PML RI + +YA+GG LN + E Y
Sbjct: 443 ---------YEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLN--SAECYY 491
Query: 404 TEKDEWTMVSPLPCAWQWSAAVVVHDCIYVM-------TLNLMYCYFPRSDSWVEMAMRQ 456
E++EW M++ + + V+H+CIY LN + Y +++W +A +
Sbjct: 492 PERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMK 551
Query: 457 TSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSV--TVEIYDVNKNEWKMAAN 514
RS +I+ +GG DG + +VE YD + + W
Sbjct: 552 HRRSALGITVHQGRIYVLGG---------------YDGHTFLDSVECYDPDTDTWSEVTR 596
Query: 515 IPAKRYS-------DPCVRAVVISNSLC 535
+ + R +PC + + N C
Sbjct: 597 MTSGRSGVGVAVTMEPCRKQIDQQNCTC 624
Score = 37.4 bits (85), Expect = 0.042
Identities = 34/153 (22%), Positives = 60/153 (39%), Gaps = 20/153 (13%)
Query: 261 LGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYI 320
+G+ +++ + L S+ CY P+ + +++ + + V N IY
Sbjct: 463 VGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNE-WRMITAMNTIRSGAGVCVLHNCIYA 521
Query: 321 AGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEG 380
AGG + +L + R +D + TW PM R + +G
Sbjct: 522 AGG----------YDGQDQLNSVER-------YDVETETWTFVAPMKHRRSALGITVHQG 564
Query: 381 YIYAIGGDSVGGELNRRTVERYDTEKDEWTMVS 413
IY +GG G +VE YD + D W+ V+
Sbjct: 565 RIYVLGG--YDGHTFLDSVECYDPDTDTWSEVT 595
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.133 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,517,816
Number of Sequences: 37866
Number of extensions: 942142
Number of successful extensions: 2972
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 175
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 1975
Number of HSP's gapped (non-prelim): 488
length of query: 623
length of database: 18,247,518
effective HSP length: 108
effective length of query: 515
effective length of database: 14,157,990
effective search space: 7291364850
effective search space used: 7291364850
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.