Search of human proteins with 221316667

Search of human proteins with 221316667

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221316667 RNA pseudouridylate synthase domain containing 4
isoform b [Homo sapiens]
         (346 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221316667 RNA pseudouridylate synthase domain containing 4 is...   698   0.0  
gi|221316663 RNA pseudouridylate synthase domain containing 4 is...   682   0.0  
gi|216548145 RNA pseudouridylate synthase domain containing 3 is...   110   2e-24
gi|216548152 RNA pseudouridylate synthase domain containing 3 is...    90   3e-18
gi|23308689 RNA pseudouridylate synthase domain containing 2 [Ho...    80   3e-15
gi|17158025 RNA pseudouridylate synthase domain containing 1 [Ho...    45   1e-04
gi|115387118 hypothetical protein LOC57562 [Homo sapiens]              31   1.4  
gi|116686122 kinesin family member 4 [Homo sapiens]                    30   2.4  
gi|34222104 hypothetical protein LOC26074 [Homo sapiens]               28   9.2  
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]             28   9.2  
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]             28   9.2  

>gi|221316667 RNA pseudouridylate synthase domain containing 4
           isoform b [Homo sapiens]
          Length = 346

 Score =  698 bits (1801), Expect = 0.0
 Identities = 346/346 (100%), Positives = 346/346 (100%)

Query: 1   MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK 60
           MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK
Sbjct: 1   MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK 60

Query: 61  KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG 120
           KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG
Sbjct: 61  KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG 120

Query: 121 PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ 180
           PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ
Sbjct: 121 PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ 180

Query: 181 VVKKYWAITVHVPMPSAGVVDIPIVEKEAQVAVTQYQVLSSTLSSALVELQPITGIKHQL 240
           VVKKYWAITVHVPMPSAGVVDIPIVEKEAQVAVTQYQVLSSTLSSALVELQPITGIKHQL
Sbjct: 181 VVKKYWAITVHVPMPSAGVVDIPIVEKEAQVAVTQYQVLSSTLSSALVELQPITGIKHQL 240

Query: 241 RVHLSFGLDCPILGDHKYSDWNRLAPQKLSVGTLKKLGLEQSKARYIPLHLHARQLILPA 300
           RVHLSFGLDCPILGDHKYSDWNRLAPQKLSVGTLKKLGLEQSKARYIPLHLHARQLILPA
Sbjct: 241 RVHLSFGLDCPILGDHKYSDWNRLAPQKLSVGTLKKLGLEQSKARYIPLHLHARQLILPA 300

Query: 301 LGSGKEELNLVCKLPRFFVHSLHRLRLEMPNEDQNENNEAKCLGAQ 346
           LGSGKEELNLVCKLPRFFVHSLHRLRLEMPNEDQNENNEAKCLGAQ
Sbjct: 301 LGSGKEELNLVCKLPRFFVHSLHRLRLEMPNEDQNENNEAKCLGAQ 346


>gi|221316663 RNA pseudouridylate synthase domain containing 4
           isoform a [Homo sapiens]
          Length = 377

 Score =  682 bits (1759), Expect = 0.0
 Identities = 346/377 (91%), Positives = 346/377 (91%), Gaps = 31/377 (8%)

Query: 1   MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK 60
           MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK
Sbjct: 1   MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTK 60

Query: 61  KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG 120
           KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG
Sbjct: 61  KEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGG 120

Query: 121 PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ 180
           PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ
Sbjct: 121 PGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQ 180

Query: 181 VVKKYWAITVHVPMPSAGVVDIPIVEKEAQ------------------------------ 210
           VVKKYWAITVHVPMPSAGVVDIPIVEKEAQ                              
Sbjct: 181 VVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNA 240

Query: 211 -VAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKL 269
            VAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKL
Sbjct: 241 QVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKL 300

Query: 270 SVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM 329
           SVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM
Sbjct: 301 SVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM 360

Query: 330 PNEDQNENNEAKCLGAQ 346
           PNEDQNENNEAKCLGAQ
Sbjct: 361 PNEDQNENNEAKCLGAQ 377


>gi|216548145 RNA pseudouridylate synthase domain containing 3
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  110 bits (275), Expect = 2e-24
 Identities = 82/279 (29%), Positives = 138/279 (49%), Gaps = 43/279 (15%)

Query: 91  LAKALTRGILHQDKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLHGHKAEPLHLCH 150
           L  AL   ++ +   LV +NKP GLPV G PG +L +  VLP L++ L G + + L +  
Sbjct: 75  LVDALRAAVVDRKGPLVTLNKPQGLPVTGKPG-ELTLFSVLPELSQSL-GLREQELQVVR 132

Query: 151 RLDKETTGVMVLAWDKDMAHQVQELF----RTRQVVKKYWAITVHVPMPSAGVVD----- 201
              KE++G+++L+     A ++Q+ F    R ++    Y A+T  +P  S G +      
Sbjct: 133 ASGKESSGLVLLSSCPQTASRLQKYFTHARRAQRPTATYCAVTDGIPAASEGKIQAALKL 192

Query: 202 ---------IPI-------VEKEAQVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLS 245
                    +P+       + +  +  ++ ++V+++    ALV+LQP+T    QL+VH+ 
Sbjct: 193 EHIDGVNLTVPVKAPSRKDILEGVKKTLSHFRVVATGSGCALVQLQPLTVFSSQLQVHMV 252

Query: 246 FGLDCPILGDHKYS---------------DWNRLAPQKLSVGTLKKLGLEQSKARYIPLH 290
             L CP+LGDH YS               + N+   Q L    L++L L  S+A  +PLH
Sbjct: 253 LQL-CPVLGDHMYSARVGTVLGQRFLLPAENNKPQRQVLDEALLRRLHLTPSQAAQLPLH 311

Query: 291 LHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEM 329
           LH  +L+LP   +    + L+  LP +F  +L  L L +
Sbjct: 312 LHLHRLLLPGTRARDTPVELLAPLPPYFSRTLQCLGLRL 350


>gi|216548152 RNA pseudouridylate synthase domain containing 3
           isoform 2 [Homo sapiens]
          Length = 336

 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 70/251 (27%), Positives = 122/251 (48%), Gaps = 43/251 (17%)

Query: 119 GGPGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELF-- 176
           G PG +L +  VLP L++ L G + + L +     KE++G+++L+     A ++Q+ F  
Sbjct: 88  GKPG-ELTLFSVLPELSQSL-GLREQELQVVRASGKESSGLVLLSSCPQTASRLQKYFTH 145

Query: 177 --RTRQVVKKYWAITVHVPMPSAGVVD--------------IPI-------VEKEAQVAV 213
             R ++    Y A+T  +P  S G +               +P+       + +  +  +
Sbjct: 146 ARRAQRPTATYCAVTDGIPAASEGKIQAALKLEHIDGVNLTVPVKAPSRKDILEGVKKTL 205

Query: 214 TQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYS-------------- 259
           + ++V+++    ALV+LQP+T    QL+VH+   L CP+LGDH YS              
Sbjct: 206 SHFRVVATGSGCALVQLQPLTVFSSQLQVHMVLQL-CPVLGDHMYSARVGTVLGQRFLLP 264

Query: 260 -DWNRLAPQKLSVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFF 318
            + N+   Q L    L++L L  S+A  +PLHLH  +L+LP   +    + L+  LP +F
Sbjct: 265 AENNKPQRQVLDEALLRRLHLTPSQAAQLPLHLHLHRLLLPGTRARDTPVELLAPLPPYF 324

Query: 319 VHSLHRLRLEM 329
             +L  L L +
Sbjct: 325 SRTLQCLGLRL 335


>gi|23308689 RNA pseudouridylate synthase domain containing 2 [Homo
           sapiens]
          Length = 545

 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 74/237 (31%), Positives = 119/237 (50%), Gaps = 28/237 (11%)

Query: 38  STAINAQRLA---EKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKA 94
           ST   AQ LA     +RA + + + K  PV    +  +  + +R T  + R  P V A+ 
Sbjct: 167 STEFRAQPLAYYEAAVRAGRLQLNEK--PVQDLNIVLKDNDFLRNT--VHRHEPPVTAEP 222

Query: 95  LTRGILHQDKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDK 154
           +   +L +++++VV++KP  +PVH  P  +     V+ IL K    H+ + LH  HRLD+
Sbjct: 223 IR--LLAENEDVVVVDKPSSIPVH--PCGRFRHNTVIFILGKE---HQLKELHPLHRLDR 275

Query: 155 ETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSAGV------------VDI 202
            T+GV++ A    ++ ++ E  R RQ+ K+Y    V    P+  V            V +
Sbjct: 276 LTSGVLMFAKTAAVSERIHEQVRDRQLEKEY-VCRVEGEFPTEEVTCKEPILVVSYKVGV 334

Query: 203 PIVEKEAQVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYS 259
             V+   +   T +Q LS    S++V  +P+TG  HQ+RVHL F L  PIL D  Y+
Sbjct: 335 CRVDPRGKPCETVFQRLSYNGQSSVVRCRPLTGRTHQIRVHLQF-LGHPILNDPIYN 390


>gi|17158025 RNA pseudouridylate synthase domain containing 1 [Homo
           sapiens]
          Length = 312

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 39/134 (29%), Positives = 62/134 (46%), Gaps = 23/134 (17%)

Query: 149 CHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWA----------ITVHVPM---P 195
           CH+LD  T+G + +A +K  A      F+ R+V K Y A          +T+   +    
Sbjct: 63  CHQLDFSTSGALCVALNKAAAGSAYRCFKERRVTKAYLALLRGHIQESRVTISHAIGRNS 122

Query: 196 SAGVVDIPIVE-----KEAQVAVTQYQVLSSTLSS----ALVELQPITGIKHQLRVHLSF 246
           + G      +E     +  + ++T   VL   L +    + V L+P+TG  HQLRVH S 
Sbjct: 123 TEGRAHTMCIEGSQGCENPKPSLTDLVVLEHGLYAGDPVSKVLLKPLTGRTHQLRVHCS- 181

Query: 247 GLDCPILGDHKYSD 260
            L  P++GD  Y +
Sbjct: 182 ALGHPVVGDLTYGE 195


>gi|115387118 hypothetical protein LOC57562 [Homo sapiens]
          Length = 1117

 Score = 31.2 bits (69), Expect = 1.4
 Identities = 14/62 (22%), Positives = 28/62 (45%)

Query: 26  LVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQR 85
           L  +  C   A    + + R  +    +++EQ+ K+  +    +Q+R Q+    T + QR
Sbjct: 61  LQQQKICRNRARKYFVESNRRKKAFEEKRKEQEEKEHQIREQILQQRKQKFEEVTEKFQR 120

Query: 86  VH 87
            H
Sbjct: 121 AH 122


>gi|116686122 kinesin family member 4 [Homo sapiens]
          Length = 1232

 Score = 30.4 bits (67), Expect = 2.4
 Identities = 52/235 (22%), Positives = 95/235 (40%), Gaps = 33/235 (14%)

Query: 32  CAAAAAST---AINAQRLAEKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQRVHP 88
           C + A S     +N  R A++ R  K +     +P  T  +    Q++ +    L + H 
Sbjct: 312 CVSPADSNLEETLNTLRYADRARKIKNKPIVNIDP-QTAELNHLKQQVQQLQVLLLQAHG 370

Query: 89  NVLAKALT-------RGILHQDKNLVVINKPY--GLPVHGGPGVQLCITDVLPILAKMLH 139
             L  ++T       + ++ ++++LV  N+    GL    G   Q+    +L   A    
Sbjct: 371 GTLPGSITVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKM 430

Query: 140 GHKAEPL--HLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSA 197
             K E L  H   +LD +   ++    D+++   V+ +   +Q++ +    TV      A
Sbjct: 431 NAKLEELRQHAACKLDLQK--LVETLEDQELKENVEIICNLQQLITQLSDETVAC---MA 485

Query: 198 GVVDIPIVEKEAQVAV------------TQYQVLSSTLSSALVELQPITGIKHQL 240
             +D   VE+EAQV              TQ+ +  + +S  LVEL     +K  L
Sbjct: 486 AAIDTA-VEQEAQVETSPETSRSSDAFTTQHALRQAQMSKELVELNKALALKEAL 539


>gi|34222104 hypothetical protein LOC26074 [Homo sapiens]
          Length = 1237

 Score = 28.5 bits (62), Expect = 9.2
 Identities = 23/106 (21%), Positives = 46/106 (43%), Gaps = 13/106 (12%)

Query: 23   LFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTKK-EPVSTNAVQRRVQEIVRFTR 81
            L++  ++P+C A      I+ ++   ++ A K E+D    E ++       +    +  +
Sbjct: 1139 LYSYFTEPWCLALFHDRFIDLRKELRQILASKEEEDLPSIEQLAHQIEDEEINPTEKPRQ 1198

Query: 82   QLQRVHPNVLAKAL----TRGILHQDKNLVVINKPYGLPVHGGPGV 123
             L+RV    + K L    T   LH ++        Y LP++  PG+
Sbjct: 1199 YLKRVFEESIYKTLVERSTLDYLHYNR--------YHLPMYAWPGI 1236


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score = 28.5 bits (62), Expect = 9.2
 Identities = 13/52 (25%), Positives = 25/52 (48%)

Query: 274 LKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRL 325
           L K+G+  S+ R     LH    +L  L    E++  + +  +F++H +  L
Sbjct: 573 LYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQIIQYDKFYIHEVQEL 624


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score = 28.5 bits (62), Expect = 9.2
 Identities = 13/52 (25%), Positives = 25/52 (48%)

Query: 274 LKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRL 325
           L K+G+  S+ R     LH    +L  L    E++  + +  +F++H +  L
Sbjct: 573 LYKIGIPPSERRIFNSFLHTALKVLEILHRVNEKMGQIIQYDKFYIHEVQEL 624


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,443,877
Number of Sequences: 37866
Number of extensions: 589221
Number of successful extensions: 1368
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1348
Number of HSP's gapped (non-prelim): 15
length of query: 346
length of database: 18,247,518
effective HSP length: 103
effective length of query: 243
effective length of database: 14,347,320
effective search space: 3486398760
effective search space used: 3486398760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.