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Search of human proteins with 115387102
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115387102 adenylate cyclase 2 [Homo sapiens]
(1091 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115387102 adenylate cyclase 2 [Homo sapiens] 2192 0.0
gi|24497587 adenylate cyclase 4 [Homo sapiens] 1187 0.0
gi|4557255 adenylate cyclase 7 [Homo sapiens] 1123 0.0
gi|34486092 adenylate cyclase 5 [Homo sapiens] 707 0.0
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 684 0.0
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 677 0.0
gi|4557257 adenylate cyclase 8 [Homo sapiens] 648 0.0
gi|31083193 adenylate cyclase 1 [Homo sapiens] 604 e-172
gi|148536830 adenylate cyclase 3 [Homo sapiens] 587 e-167
gi|50959205 adenylate cyclase 9 [Homo sapiens] 225 2e-58
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 122 2e-27
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 122 2e-27
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 122 2e-27
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 122 2e-27
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 122 2e-27
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 122 2e-27
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 116 1e-25
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 113 1e-24
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 113 1e-24
gi|134152694 guanylate cyclase 2F [Homo sapiens] 113 1e-24
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 107 5e-23
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 100 1e-20
gi|222080083 guanylate cyclase 2C [Homo sapiens] 99 2e-20
gi|209976994 adenylate cyclase 10 [Homo sapiens] 39 0.027
gi|24308169 dynein, axonemal, heavy chain 3 [Homo sapiens] 32 3.3
gi|6912278 COMM domain containing 3 [Homo sapiens] 32 3.3
gi|5803173 solute carrier family 20, member 2 [Homo sapiens] 32 3.3
gi|239746595 PREDICTED: hypothetical protein XP_002343793 [Homo ... 31 5.6
gi|46240864 sperm associated antigen 17 [Homo sapiens] 31 5.6
gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 31 7.3
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 2192 bits (5681), Expect = 0.0
Identities = 1091/1091 (100%), Positives = 1091/1091 (100%)
Query: 1 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLA 60
MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLA
Sbjct: 1 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLA 60
Query: 61 LLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAM 120
LLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAM
Sbjct: 61 LLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAM 120
Query: 121 GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT 180
GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT
Sbjct: 121 GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT 180
Query: 181 PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ 240
PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ
Sbjct: 181 PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ 240
Query: 241 ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT 300
ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT
Sbjct: 241 ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT 300
Query: 301 RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK 360
RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK
Sbjct: 301 RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK 360
Query: 361 MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG 420
MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG
Sbjct: 361 MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG 420
Query: 421 VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR 480
VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR
Sbjct: 421 VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR 480
Query: 481 HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL 540
HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL
Sbjct: 481 HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL 540
Query: 541 RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAF 600
RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAF
Sbjct: 541 RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAF 600
Query: 601 KYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP 660
KYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP
Sbjct: 601 KYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP 660
Query: 661 LLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS 720
LLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS
Sbjct: 661 LLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS 720
Query: 721 ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHT 780
ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHT
Sbjct: 721 ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHT 780
Query: 781 HAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK 840
HAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK
Sbjct: 781 HAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK 840
Query: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY
Sbjct: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
Query: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS
Sbjct: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
Query: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI
Sbjct: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
Query: 1021 WGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEM 1080
WGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEM
Sbjct: 1021 WGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEM 1080
Query: 1081 SRSLSQSNVAS 1091
SRSLSQSNVAS
Sbjct: 1081 SRSLSQSNVAS 1091
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 1187 bits (3071), Expect = 0.0
Identities = 605/1070 (56%), Positives = 772/1070 (72%), Gaps = 23/1070 (2%)
Query: 27 PRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTAL 86
P S D YE+YY +SQQ+PL++ LL IV+ + ALLAV +A G E+ +FL TV AL
Sbjct: 10 PPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCAL 69
Query: 87 AIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFV 146
F + L E ++ R S ++W+ L+A+G+ F+ GG VS WDQVS+FLF+IF
Sbjct: 70 GGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFT 129
Query: 147 VYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGA 206
Y MLP MRDA +A + +S SH +VL + L P + L+ Q+ AN ++F+CGN+AG
Sbjct: 130 AYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGV 189
Query: 207 YHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQG 266
YHK LME AL+ T+++ + + SR +L+ EK+ QE LLLS+LPA++A EMKAEI+ RLQ
Sbjct: 190 YHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQA 249
Query: 267 PKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIA 326
+ + E+TNNFH+LYVKRH VS+LYADIVGFTRLAS+CSP ELV MLNELFGKFDQIA
Sbjct: 250 GQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIA 309
Query: 327 KENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGV 386
KE+ECMRIKILGDCYYCVSGLP+SLP+HA NCV+MGLDMC AI+K+R ATGVDINMRVGV
Sbjct: 310 KEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGV 369
Query: 387 HSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDG 446
HSG+VLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHI+ TL L GAY VE+
Sbjct: 370 HSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGM 429
Query: 447 DIRDPYLKQHLVKTYFVINPKGERRSPQHLFRP-RHTLDGAKMRASVRMTRYLESWGAAK 505
+ RDPYL++ TY VI+P+ E + +L+G KMR S+ MTRYLESWGAAK
Sbjct: 430 EHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAK 489
Query: 506 PFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKR----FEEEL---NERMI 558
PFAHL H DS +T P+ + + + + + R ++EL + +
Sbjct: 490 PFAHLSHGDSPV-------STSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFF 542
Query: 559 QAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQ 618
Q I+ +N+QKQW +S+D ++L F K +EKEYR +A+PAFKYY C L+F FI+Q
Sbjct: 543 QVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQ 602
Query: 619 ILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWP 678
+LV + L I++ FLL ILFVCF+ L++C K +L WL SG++A RP
Sbjct: 603 MLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGL 662
Query: 679 RISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLP 738
RI+L T ++ MA+ ++FF S + N S SN + + L +P
Sbjct: 663 RIALGTATILLVFAMAITSLFFFPTSSDC---PFQAPNVSSMISNLSWELPGSLPLISVP 719
Query: 739 YFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAH-----VLGDYSQVLF 793
Y ++ C LG +SCS+FL +++ELK+L++++ L ++ LH+HA ++ Y L
Sbjct: 720 YSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLD 779
Query: 794 ERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNR 853
RPG+ K+ K MG++S IFF TLLVL RQNEYYCRLDFLWK K ++EREE ETMENL R
Sbjct: 780 SRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTR 839
Query: 854 VLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECL 913
+LLENVLPAHVA F+ ++ +NE+LYHQSY+CVCV+FAS+PDFKEFY+ES++N EGLECL
Sbjct: 840 LLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECL 899
Query: 914 RLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTM 973
RLLNEIIADFD+LLSKPKFSGVEKIKTIGSTYMAATGL+A Q+ Q+ ER H+GTM
Sbjct: 900 RLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTM 959
Query: 974 VEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDS 1033
VEFA AL KLD INKHSFN+F+LRVG+NHGPV+AGVIGAQKPQYDIWGNTVNVASRM+S
Sbjct: 960 VEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMES 1019
Query: 1034 TGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRS 1083
TGVL KIQVTEET+ LQ+LGYTC RG+I VKGKG L TYF+NT+++R+
Sbjct: 1020 TGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRT 1069
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 1123 bits (2904), Expect = 0.0
Identities = 597/1091 (54%), Positives = 760/1091 (69%), Gaps = 41/1091 (3%)
Query: 10 RYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALG 69
RY + EE +D LYE Y SQ PL++ LLL+ +C+AL+ + F+ G
Sbjct: 6 RYFLNEGEEGP--------DQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQG 57
Query: 70 LEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYL--FMCF 127
+ H A L LA+F A+ +L+ +E + ++ LR +L+ W CLVA+GY+ F +
Sbjct: 58 -DPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAW 116
Query: 128 GGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHL 187
W+QV FFLFI+FVVYT+LPF+MR A+ ++++SH +VL + +
Sbjct: 117 TKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRV 176
Query: 188 VWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSL 247
Q+LAN +IF+CGNL GA+HKH M+ A + + T CI+ R KL EKRQQE LLLS+
Sbjct: 177 GLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSV 236
Query: 248 LPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCS 307
LPAHI+M MK II+RL+ + NNFH+LYVKRH NVSILYADIVGFT+LASDCS
Sbjct: 237 LPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCS 296
Query: 308 PGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCE 367
P ELV +LNELFGKFDQIAK NECMRIKILGDCYYCVSGLP+SLP HA+NCVKMGLDMC+
Sbjct: 297 PKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQ 356
Query: 368 AIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHI 427
AIK+VR+ATGVDINMRVG+HSGNVLCGVIGL+KWQYDVWSHDV+LAN MEA GVPGRVHI
Sbjct: 357 AIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHI 416
Query: 428 SSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSP--QHLFRPRHTLDG 485
+ TL+HL+ AY+VE+G G RDPYLK+ ++TY VI+P+ ++ P QHL RP+
Sbjct: 417 TEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDA-A 475
Query: 486 AKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL-RTKS 544
KMRASVRMTRYLESWGAA+PFAHL+HR+S+++ + P RT R+ S
Sbjct: 476 LKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMS 535
Query: 545 QKKRFEEE-LNERMIQAIDGINAQKQWL-KSEDIQRISLLFYNKVLEKEYRATALPAFKY 602
K R E++ ++ M+ AI+G+++ + KS+D +F K E+EYR +P ++
Sbjct: 536 PKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARH 595
Query: 603 YVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLL 662
CA LIF CI +V +L++P+T+ LG+SFG +L +L +CFA + +C P
Sbjct: 596 DFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRC----CPAR 651
Query: 663 MWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSAS 722
L S + +P R++L ++T +L +A+ N+ + + P N T +AS
Sbjct: 652 GTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPEL-PVGNETGL-LAAS 709
Query: 723 NNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTIL----- 777
+ A+ LPY+ SC+LG I+CSVFLR++ E K++++ VALV Y +
Sbjct: 710 SKTRALCEP-----LPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPC 764
Query: 778 --LHTHAHVLGDYSQVLFERPGI----WKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLD 831
LG+ ++ G WKDLKTM + L +F+ITLL L RQ +YYCRLD
Sbjct: 765 WQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLD 824
Query: 832 FLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFA 891
LWK KFKKE EE ETMEN+NR+LLENVLPAHVA HF+ L NE+ YHQSYDCVCVMFA
Sbjct: 825 CLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKL-NEDWYHQSYDCVCVMFA 883
Query: 892 SIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGL 951
S+PDFK FYTE DVNKEGLECLRLLNEIIADFD+LL KPKFSGVEKIKTIGSTYMAA GL
Sbjct: 884 SVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGL 943
Query: 952 SAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVI 1011
S V S +QE ERQ+ HIG MVEF+ AL+ KLD IN+HSFN F+LRVGINHGPVIAGVI
Sbjct: 944 S-VASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVI 1002
Query: 1012 GAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDL 1071
GA+KPQYDIWGNTVNVASRM+STG L KIQVTEET +LQ LGY+C CRG+INVKGKG+L
Sbjct: 1003 GARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGEL 1062
Query: 1072 KTYFVNTEMSR 1082
+TYFV T+ ++
Sbjct: 1063 RTYFVCTDTAK 1073
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 707 bits (1825), Expect = 0.0
Identities = 421/1076 (39%), Positives = 631/1076 (58%), Gaps = 80/1076 (7%)
Query: 33 LYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAI 92
LY+ Y+ Q L + + ++V+ CL +LA F A ++ + +L + A+ + +
Sbjct: 229 LYQRYFFRLNQSSLTMLMAVLVL-VCLVMLA-FHAARPPLQ--LPYLAVLAAAVGVILIM 284
Query: 93 FILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLP 152
+L + + + L + ++A+ + + S + + + +F I+ +YT+LP
Sbjct: 285 AVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLP 344
Query: 153 FNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLM 212
MR A+++ VL S+ H L++ L T + L+ Q+++NV+IF C N+ G +
Sbjct: 345 VRMRAAVLSGVLLSALH---LAIALR-TNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPA 400
Query: 213 ELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQM 272
E++ +Q +Q+T CI++R+ + E +QQERLLLS+LP H+AMEMKA+I +
Sbjct: 401 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK--------- 451
Query: 273 ENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECM 332
+ FH +Y+++H NVSIL+ADI GFT LAS C+ ELV LNELF +FD++A EN C+
Sbjct: 452 QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 511
Query: 333 RIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVL 392
RIKILGDCYYCVSGLP + +HA CV+MG+DM EAI VR+ TGV++NMRVG+HSG V
Sbjct: 512 RIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVH 571
Query: 393 CGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPY 452
CGV+GL+KWQ+DVWS+DVTLANHMEAGG GR+HI+ TL +LNG Y+VE G G R+ Y
Sbjct: 572 CGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAY 631
Query: 453 LKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKM--RASVRMTRYLESWGAAKPFAHL 510
LK+H ++T+ ++ +R+ + + AKM + + + WGA +PF +
Sbjct: 632 LKEHSIETFLILRCTQKRKEEKAMI--------AKMNRQRTNSIGHNPPHWGAERPFYNH 683
Query: 511 HHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQW 570
+ ++ E M + F++ + + E+E++E + +AID + +
Sbjct: 684 LGGNQVSKE----------MKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDR-- 731
Query: 571 LKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI 630
L+SE +++ L F LEK+Y F YV CA L+F I VQI ++P S+ +
Sbjct: 732 LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPH-SIFML 790
Query: 631 SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAII 690
SF LL + V F + C K L L + I + + T ++
Sbjct: 791 SFYLTCSLL--LTLVVFVSVIYSCVKLFPSPLQTLSRK---IVRSKMNSTLVGVFTITLV 845
Query: 691 LMMAVFNMF---------FLSDSEETIPPTANTTNTSFSASNNQVAILRA------QNLF 735
+ A NMF L+ N + + SA N + + N
Sbjct: 846 FLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCN 905
Query: 736 FLPYFIYSCILGLISCSVFLRVNYELKMLIMM------VALVGYNTILLHTHAHVLGDYS 789
F YF YS +L L++CSVFL+++ K+++M+ V +V + L +A +L +
Sbjct: 906 FPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTAN 965
Query: 790 QVLFERPGIWK--------DLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKE 841
+ F G + LK + + +S+F + L + +Q E RLDFLWK + +E
Sbjct: 966 AIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEE 1025
Query: 842 REEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYT 901
+EE+E ++ NR LL N+LP VA HFLAR +N+ELY+QS +CV VMFASI +F EFY
Sbjct: 1026 KEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYV 1085
Query: 902 ESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQ 961
E + N EG+ECLRLLNEIIADFD+++S+ +F +EKIKTIGSTYMAA+GL+ S
Sbjct: 1086 ELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLN------DST 1139
Query: 962 EPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIW 1021
+ HI + +FA L+ ++ IN+HSFN+F++++G+N GPV+AGVIGA+KPQYDIW
Sbjct: 1140 YDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIW 1199
Query: 1022 GNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVN 1077
GNTVNVASRMDSTGV D+IQVT + VL Y CRG++ VKGKG++ TYF+N
Sbjct: 1200 GNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1255
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 684 bits (1766), Expect = 0.0
Identities = 415/1074 (38%), Positives = 624/1074 (58%), Gaps = 78/1074 (7%)
Query: 33 LYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAI 92
LY+ Y+ Q L + + ++V+ A+L F A + A++ + A A+F +
Sbjct: 139 LYQRYFFQMNQSSLTLLMAVLVL--LTAVLLAFHAAPARPQP--AYVALLACAAALFVGL 194
Query: 93 FILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLP 152
++ S + + + S V+ L A+ SP + +F +++ YT+LP
Sbjct: 195 MVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLP 254
Query: 153 FNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLM 212
MR A+++ + S+ H ++L+ L+ G L Q+ ANV++F+C N+ G +
Sbjct: 255 IRMRAAVLSGLGLSTLH-LILAWQLNR---GDAFLWKQLGANVLLFLCTNVIGICTHYPA 310
Query: 213 ELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQM 272
E++ +Q +Q+T I++R+ L+ E RQQERLLLS+LP H+AMEMK +I + K M
Sbjct: 311 EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK----KEDMM 366
Query: 273 ENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECM 332
FH +Y+++H NVSIL+ADI GFT LAS C+ ELV LNELF +FD++A EN C+
Sbjct: 367 -----FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 421
Query: 333 RIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVL 392
RIKILGDCYYCVSGLP + +HA CV+MG+DM EAI VR+ TGV++NMRVG+HSG V
Sbjct: 422 RIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVH 481
Query: 393 CGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPY 452
CGV+GL+KWQ+DVWS+DVTLANHMEAGG GR+HI+ TL++LNG Y+VE G G R+ Y
Sbjct: 482 CGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAY 541
Query: 453 LKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHH 512
LK+ ++T+ ++ +R+ + + + RA+ M + W + F+
Sbjct: 542 LKEQHIETFLILGASQKRKEEKAMLAKLQ-----RTRAN-SMEGLMPRWVPDRAFSRT-- 593
Query: 513 RDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLK 572
+DS I + ++ R E+E++E + +AID + + L+
Sbjct: 594 KDSKAFRQMGIDDS----------SKDNRGTQDALNPEDEVDEFLSRAIDARSIDQ--LR 641
Query: 573 SEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISF 632
+ ++R L F + LEK+Y P F YV CA L+F I +Q+L+ P ++++ +
Sbjct: 642 KDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIY 701
Query: 633 GAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILM 692
+ FLLL + +C + C L L +S I+ +R ++ I + ++
Sbjct: 702 ASIFLLLLITVLIC---AVYSCGSLFPKALQRLSRS--IVRSRA-HSTAVGIFSVLLVFT 755
Query: 693 MAVFNMFFLSDS--EETIPPTANTTNTSFSASNNQ-----------VAILRAQNLFFLPY 739
A+ NMF + + N T +A + Q + F Y
Sbjct: 756 SAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEY 815
Query: 740 FIYSCILGLISCSVFLRVNYELKM-LIMMVALVGYNTILLHTHAHVLGDYSQVL------ 792
FI + +L L++ SVFL ++ K+ +I ++ L+ +LL A + +Y +L
Sbjct: 816 FIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLA 875
Query: 793 --------FERPGIWK-DLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKERE 843
+ P + LK M V L +F + L + +Q E RLDFLWK + E+E
Sbjct: 876 SSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKE 935
Query: 844 EIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTES 903
E+E ++ NR LL N+LP VA HFLAR +N+ELY+QS +CV VMFASI +F EFY E
Sbjct: 936 EMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVEL 995
Query: 904 DVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEP 963
+ N EG+ECLRLLNEIIADFD+++S+ +F +EKIKTIGSTYMAA+GL+A + +
Sbjct: 996 EANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS- 1054
Query: 964 ERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGN 1023
HI + ++A L+ ++ IN+HSFN+F++++G+N GPV+AGVIGA+KPQYDIWGN
Sbjct: 1055 -----HITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1109
Query: 1024 TVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVN 1077
TVNV+SRMDSTGV D+IQVT + VL GY CRG++ VKGKG++ TYF+N
Sbjct: 1110 TVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1163
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 677 bits (1748), Expect = 0.0
Identities = 409/1061 (38%), Positives = 613/1061 (57%), Gaps = 105/1061 (9%)
Query: 33 LYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAI 92
LY+ Y+ Q L + + ++V+ A+L F A + A++ + A A+F +
Sbjct: 139 LYQRYFFQMNQSSLTLLMAVLVL--LTAVLLAFHAAPARPQP--AYVALLACAAALFVGL 194
Query: 93 FILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLP 152
++ S + + + S V+ L A+ SP + +F +++ YT+LP
Sbjct: 195 MVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLP 254
Query: 153 FNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLM 212
MR A+++ + S+ H ++L+ L+ G L Q+ ANV++F+C N+ G +
Sbjct: 255 IRMRAAVLSGLGLSTLH-LILAWQLNR---GDAFLWKQLGANVLLFLCTNVIGICTHYPA 310
Query: 213 ELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQM 272
E++ +Q +Q+T I++R+ L+ E RQQERLLLS+LP H+AMEMK +I + K M
Sbjct: 311 EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK----KEDMM 366
Query: 273 ENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECM 332
FH +Y+++H NVSIL+ADI GFT LAS C+ ELV LNELF +FD++A EN C+
Sbjct: 367 -----FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 421
Query: 333 RIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVL 392
RIKILGDCYYCVSGLP + +HA CV+MG+DM EAI VR+ TGV++NMRVG+HSG V
Sbjct: 422 RIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVH 481
Query: 393 CGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPY 452
CGV+GL+KWQ+DVWS+DVTLANHMEAGG GR+HI+ TL++LNG Y+VE G G R+ Y
Sbjct: 482 CGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAY 541
Query: 453 LKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHH 512
LK+ ++T+ ++ +R+ + + + RA+ M + W + F+
Sbjct: 542 LKEQHIETFLILGASQKRKEEKAMLAKLQ-----RTRAN-SMEGLMPRWVPDRAFSRT-- 593
Query: 513 RDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLK 572
+DS I + ++ R E+E++E + +AID + + L+
Sbjct: 594 KDSKAFRQMGIDDS----------SKDNRGTQDALNPEDEVDEFLSRAIDARSIDQ--LR 641
Query: 573 SEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISF 632
+ ++R L F + LEK+Y P F YV CA L+F I +Q+L+ P ++++ +
Sbjct: 642 KDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIY 701
Query: 633 GAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILM 692
+ FLLL + +C + C L L +S I+ +R ++ I + ++
Sbjct: 702 ASIFLLLLITVLIC---AVYSCGSLFPKALQRLSRS--IVRSRA-HSTAVGIFSVLLVFT 755
Query: 693 MAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCS 752
A+ NM YFI + +L L++ S
Sbjct: 756 SAIANM----------------------------------------YFIGNMLLSLLASS 775
Query: 753 VFLRVNYELKM-LIMMVALVGYNTILLHTHAHVLGDYSQVL--------------FERPG 797
VFL ++ K+ +I ++ L+ +LL A + +Y +L + P
Sbjct: 776 VFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA 835
Query: 798 IWK-DLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLL 856
+ LK M V L +F + L + +Q E RLDFLWK + E+EE+E ++ NR LL
Sbjct: 836 AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLL 895
Query: 857 ENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLL 916
N+LP VA HFLAR +N+ELY+QS +CV VMFASI +F EFY E + N EG+ECLRLL
Sbjct: 896 HNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLL 955
Query: 917 NEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEF 976
NEIIADFD+++S+ +F +EKIKTIGSTYMAA+GL+A + + HI + ++
Sbjct: 956 NEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS------HITALADY 1009
Query: 977 AFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGV 1036
A L+ ++ IN+HSFN+F++++G+N GPV+AGVIGA+KPQYDIWGNTVNV+SRMDSTGV
Sbjct: 1010 AMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGV 1069
Query: 1037 LDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVN 1077
D+IQVT + VL GY CRG++ VKGKG++ TYF+N
Sbjct: 1070 PDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1110
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 648 bits (1671), Expect = 0.0
Identities = 395/1066 (37%), Positives = 614/1066 (57%), Gaps = 76/1066 (7%)
Query: 28 RSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALA 87
R + LY+ Y+ ++ +V +L V+ L LL + +L D + ++ L
Sbjct: 164 RDLERLYQRYFLGQRRKSEVVMNVLDVLTK-LTLLVLHLSLASAPMDPLKGIL-----LG 217
Query: 88 IFFAIFILVCIESVFKK------LLRLFSLVIWICL----VAMGYLFMCFGGTVSPWDQV 137
F I +++C V +K L+ +V W+ + +A G + G D +
Sbjct: 218 FFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLG------DGI 271
Query: 138 SFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVII 197
+ LF +F Y+MLP + AI+A + TS I+ V P + Q++A ++
Sbjct: 272 GYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVI----PRLAVISINQVVAQAVL 327
Query: 198 FICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMK 257
F+C N AG + +L + A +Q + +T C+++R++LE E ++QERL+LS+LP + +EM
Sbjct: 328 FMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEM- 386
Query: 258 AEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNE 317
I + + +++ FH +Y+ R+ NVSIL+AD+ GFT L++ S ELV MLNE
Sbjct: 387 ---INDMTNVEDEHLQH--QFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNE 441
Query: 318 LFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATG 377
LF +FD++A E+ C+RIKILGDCYYCVSGLP +HA CV+MGL M + I+ VR T
Sbjct: 442 LFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTK 501
Query: 378 VDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNG 437
D++MR+G+HSG+VLCGV+GL+KWQ+DVWS DV +AN +E+GG+PGR+HIS TL+ LNG
Sbjct: 502 HDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNG 561
Query: 438 AYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRS-PQHLFRPRHTLDGAKMRASVRMTR 496
Y VEEG G R+ +L++H ++TY + P+ S P+ + + + + R + T
Sbjct: 562 DYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVS---SSDRRNSGATF 618
Query: 497 YLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNER 556
SW PF ++ + + + S +P N + L +S EE+N+R
Sbjct: 619 TEGSWSPELPFDNIVGKQNTLAALTRNSINLLP----NHLAQALHVQSG----PEEINKR 670
Query: 557 MIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFI 616
+ ID + K L+ E I+ SL+F + LE +Y FK + CA ++ I
Sbjct: 671 IEHTIDLRSGDK--LRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITA 728
Query: 617 VQILVLPKTSV--LGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIAN 674
+Q L LP + V + I F +L + ++ + A K PL +L+ + N
Sbjct: 729 IQSL-LPSSRVMPMTIQFSILIMLHSALVLITTAEDY-----KCLPL---ILRKTCCWIN 779
Query: 675 RPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNL 734
+ ++ I + +I + D +++IP N +F++S I
Sbjct: 780 ETYLARNVIIFASILINFLGAILNILWCDFDKSIP----LKNLTFNSSAVFTDICS---- 831
Query: 735 FFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFE 794
+ YF+++ +L +++C+VFLR+N LK+ ++++ + Y + +A + Y L
Sbjct: 832 -YPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDN-LNH 889
Query: 795 RPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRV 854
+ K + + +++F + + G+Q EY RLDFLW+ + K+E E++ + N
Sbjct: 890 SGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNEN 949
Query: 855 LLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLR 914
+L N+LP+HVA HFL + NEELY QSYD V VMFASIP F +FY+++++N +G+ECLR
Sbjct: 950 MLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLR 1009
Query: 915 LLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMV 974
LLNEIIADFD+LL + +F +EKIKTIGSTYMA +GLS Q+ E ++ H+ +
Sbjct: 1010 LLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLS-----PEKQQCEDKWGHLCALA 1064
Query: 975 EFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDST 1034
+F+ AL + INKHSFN+F+LR+GI+HG V+AGVIGA+KPQYDIWG TVN+ASRMDST
Sbjct: 1065 DFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDST 1124
Query: 1035 GVLDKIQVTEETSLVLQTLGYTCTCRGIINVKG----KGDLKTYFV 1076
GV +IQV EET L+L+ G+ RG I VKG +G +KTYF+
Sbjct: 1125 GVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1170
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 604 bits (1558), Expect = e-172
Identities = 388/1045 (37%), Positives = 572/1045 (54%), Gaps = 117/1045 (11%)
Query: 83 PTALAIFFAIFILVCIESV-------FKKLLRLFSLVIWI--CLVAMGYLFM----CFGG 129
P +F A+ ++ + S+ +L LFSL + C A+G GG
Sbjct: 96 PVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGG 155
Query: 130 TVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVW 189
+ V L + FV Y +LP AI ++ ++SH +V + + A K +W
Sbjct: 156 PATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPA----KRPRLW 211
Query: 190 QIL-ANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLL 248
+ L AN ++F+ N+ G + + L E + ++ + +CI+ R++LE E +QERLL+SLL
Sbjct: 212 RTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLL 271
Query: 249 PAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSP 308
P ++AMEMK + ++ + FH +Y++RH NVSIL+ADIVGFT LAS C+
Sbjct: 272 PRNVAMEMKEDFLKPPE----------RIFHKIYIQRHDNVSILFADIVGFTGLASQCTA 321
Query: 309 GELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEA 368
ELV +LNELFGKFD++A EN C RIKILGDCYYCVSGL +HA CV+MGLDM +
Sbjct: 322 QELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDT 381
Query: 369 IKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHIS 428
I V +AT VD+NMRVG+H+G VLCGV+GL+KWQYDVWS+DVTLAN MEA G+PG+VHI+
Sbjct: 382 ITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHIT 441
Query: 429 SVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKM 488
TL LNG Y+VE G G R+ +LK H ++T+F++ P H R + +
Sbjct: 442 KTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIV--------PSH----RRKIFPGLI 489
Query: 489 RASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKR 548
+ ++ + ++ L H M +I ++V + + + R LRT S+K R
Sbjct: 490 LSDIKPAKRMKFKTVCYLLVQLMHCRKMF--KAEIPFSNVMTCEDDDKRRALRTASEKLR 547
Query: 549 FEEELNERMIQAIDG----------INAQKQWLKSEDIQRISLLFYNKVLEKEYRATALP 598
+ ++ G + A++ L+ D+ +L + + E++Y
Sbjct: 548 NRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDE 607
Query: 599 AFKYYVTCACLIFFCIFIVQILVLPKTSV--LGISFGAAFLLLAFILFV------CFAGQ 650
F V ++ +V +L+ P++ V L + F F L+A +L++ CF G
Sbjct: 608 YFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICF-LVACVLYLHITRVQCFPGC 666
Query: 651 L-LQCSKKASPLLMWLLKSSG---IIANRPW-----PRISLTIITTAIILMMAVFNMFFL 701
L +Q ++ L+ S ++ PW P SL +++
Sbjct: 667 LTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLS--------------- 711
Query: 702 SDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYEL 761
S + T PT +T + + C++G + ++F RV+
Sbjct: 712 SGGQRTALPTLPCESTH--------------------HALLCCLVGTLPLAIFFRVSSLP 751
Query: 762 KMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLG 821
KM+++ Y +L L Y++ G V++ +F L +
Sbjct: 752 KMILLSGLTTSYILVL------ELSGYTRT---GGGAVSGRSYEPIVAILLFSCALALHA 802
Query: 822 RQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQ 881
RQ + RLD+LW + ++ERE++E ++ NR +L N+LPAHVA+HFL + +N +LY+Q
Sbjct: 803 RQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQ 862
Query: 882 SYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTI 941
SY V VMFASIP+F +FY E D N G+ECLRLLNEIIADFD+L+ K + +EKIKTI
Sbjct: 863 SYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTI 922
Query: 942 GSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGI 1001
GSTYMAA GL+ + + H+ T+ +FA + LD IN S+NDF LRVGI
Sbjct: 923 GSTYMAAVGLAPTSGTKAKKSIS---SHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGI 979
Query: 1002 NHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRG 1061
N GPV+AGVIGA++PQYDIWGNTVNVASRMDSTGV +IQVTEE +L+ Y CRG
Sbjct: 980 NVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRG 1039
Query: 1062 IINVKGKGDLKTYFVNTEMSRSLSQ 1086
++VKGKG++ TYF+ + SQ
Sbjct: 1040 KVSVKGKGEMLTYFLEGRTDGNGSQ 1064
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 587 bits (1514), Expect = e-167
Identities = 379/1102 (34%), Positives = 584/1102 (52%), Gaps = 91/1102 (8%)
Query: 26 LPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSC--LALLAVFFALGLEVEDHVAFLITVP 83
+P S + LY++Y+ + L+V ++ + C + + AV F+ D +A L
Sbjct: 58 VPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFS-----SDKLASLAVAG 112
Query: 84 TALAIFFAIFILVCIESVFKKLL--RLFSLVIWICLVAM--GYLFMCFGGTVSPWDQVSF 139
L + +F+L C + + + R+ V+W+ + A YL + F + D V +
Sbjct: 113 IGLVLDIILFVL-CKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGW 171
Query: 140 FLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGK---EHLVWQILANVI 196
+F +F + LP ++ +I SV++ HT+VL V ++ + L+ +ILANV
Sbjct: 172 QVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVF 231
Query: 197 IFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEM 256
+++C G ++ + ++ + + ++ ++ LE + +QQE L+LS+LP H+A EM
Sbjct: 232 LYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEM 291
Query: 257 KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLN 316
++ K ++ F+ +Y+ RH NVSIL+ADIVGFT+L+S CS ELV +LN
Sbjct: 292 LKDM------KKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLN 345
Query: 317 ELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDAT 376
ELF +FD++A + +RIKILGDCYYC+ GLP +HA + MGL M EAI VR+ T
Sbjct: 346 ELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKT 405
Query: 377 GVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLN 436
++MRVGVH+G VL GV+G ++WQYDVWS DVT+AN MEAGG+PGRVHIS T++ L
Sbjct: 406 KTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLK 465
Query: 437 GAYKVEEGDGDIRDPYLKQHLVKTYFVI--NPKGERRSPQHLFRPRHTLDGAKMRASVRM 494
G + VE GDG R YL++ ++TY +I P+ ++ + Q+ +GA +
Sbjct: 466 GEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSS 525
Query: 495 TRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQN--RTLRTKSQKKRF--- 549
+E+ +P H S T+E K D +F N R LR + R
Sbjct: 526 PALIET---KEPNGSAHSSGS-TSE--KPEEQDAQADNPSFPNPRRRLRLQDLADRVVDA 579
Query: 550 ---EEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTC 606
E ELN+ + +A+ Q +K + +S+ F + +E Y +C
Sbjct: 580 SEDEHELNQLLNEALLE-RESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSC 638
Query: 607 ACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCS--KKASPLLMW 664
+C++ C +V+IL+ P ++F +LL IL +C + + KK W
Sbjct: 639 SCVVLLCTALVEILIDPWLMTNYVTFMVGEILL-LILTICSLAAIFPRAFPKKLVAFSTW 697
Query: 665 LLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNN 724
+ ++ A W +++ I+ A ++ M ++ S T T S N
Sbjct: 698 IDRTRW--ARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATA-----GMETEGSCLEN 750
Query: 725 QVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHV 784
Y+ Y +L LI+ + ++V++ +K+ +M++ TI L+ V
Sbjct: 751 P------------KYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPV 798
Query: 785 LGDYSQVLFE---------------RPGI-------WKDLKTMGSVSLSIFFITLLVLGR 822
+Y F PG+ K +V + + ++ R
Sbjct: 799 FDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSR 858
Query: 823 QNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQS 882
E R FLWK + ++E + M N L+ N+LP HVA HFL ++EELY Q+
Sbjct: 859 HVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQT 918
Query: 883 YDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIG 942
YD + VMFAS+P+F +FYTE +N G+ECLR LNEII+DFD LL PKF + KIKTIG
Sbjct: 919 YDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIG 978
Query: 943 STYMAATGLS--------AVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFND 994
STYMAA+G++ A ++E E ER + H+ + +FA A+ L IN SFN+
Sbjct: 979 STYMAASGVTPDVNTNGFASSNKEDKSERER-WQHLADLADFALAMKDTLTNINNQSFNN 1037
Query: 995 FKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLG 1054
F LR+G+N G V+AGVIGA+KP YDIWGNTVNVASRM+STGV+ IQV EET ++L+ G
Sbjct: 1038 FMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYG 1097
Query: 1055 YTCTCRGIINVKGKGDLKTYFV 1076
+ RG I VKGKG+L T+F+
Sbjct: 1098 FRFVRRGPIFVKGKGELLTFFL 1119
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 225 bits (574), Expect = 2e-58
Identities = 184/564 (32%), Positives = 276/564 (48%), Gaps = 77/564 (13%)
Query: 547 KRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRAT----------- 595
K E+ + + I + K + I + SL F ++ LE+ YR +
Sbjct: 718 KNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPV 777
Query: 596 ---ALPAFKYY--VTCACLIFF-----CIFIVQILVLPKTSVLGISFGAAFLLLAFIL-- 643
A P F V + +F C + +P F AA LL L
Sbjct: 778 KTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAV 837
Query: 644 ---FVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPW-PRISLTIITTAIILMMAVFNMF 699
V F ++ C+K+ LL W+ W PR + I ++ + AV+
Sbjct: 838 SIRMVFFLEDVMACTKR---LLEWIAG---------WLPRHCIGAILVSLPAL-AVY--- 881
Query: 700 FLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNY 759
S T N F+ S +A++ N L ++ S + ++
Sbjct: 882 ----SHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAG------- 930
Query: 760 ELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKT----MGSVSLSIFFI 815
+L++ V+L +++L V S+ + +DL+ +G + +FF+
Sbjct: 931 --PLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFL 988
Query: 816 TLLV---LGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARS 872
LL+ L R+ E RL + + R +I++M + LL N++P HVAE
Sbjct: 989 LLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQ----- 1043
Query: 873 LKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKF 932
LK + Y +++D V+FASI +F EFY E+ + G EC R+LNE+I DFD+LLSKP +
Sbjct: 1044 LKVSQTYSKNHDSGGVIFASIVNFSEFYEEN--YEGGKECYRVLNELIGDFDELLSKPDY 1101
Query: 933 SGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHS- 991
S +EKIKTIG+TYMAA+GL+ +Q+ S E H+ + EFA ++ +D N +
Sbjct: 1102 SSIEKIKTIGATYMAASGLNTAQAQDGSHPQE----HLQILFEFAKEMMRVVDDFNNNML 1157
Query: 992 -FNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVL 1050
FN FKLRVG NHGP+ AGVIG K YDIWG+TVN+ASRMD+TGV +IQV+EE+ VL
Sbjct: 1158 WFN-FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVL 1216
Query: 1051 QTLGYTCTCRGIINVKGKGDLKTY 1074
+GY RG +NVKGKG +KTY
Sbjct: 1217 SKMGYDFDYRGTVNVKGKGQMKTY 1240
Score = 190 bits (482), Expect = 7e-48
Identities = 138/453 (30%), Positives = 232/453 (51%), Gaps = 59/453 (13%)
Query: 39 CMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCI 98
C Q + L + +CL L +++FA+ H+ + V A A+ F+LVC+
Sbjct: 108 CFPQTQRRFRYALFYIGFACL-LWSIYFAV------HMRSRLIVMVAPAL---CFLLVCV 157
Query: 99 ES---VFKKL---------LRLFSLVIWICLVAMGYLFMCFGG---------TVSPWD-- 135
F KL L L LV + L A + G T P D
Sbjct: 158 GFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTC 217
Query: 136 --QVSFF---LFIIFVVYTMLPFNMRDAIIASVLTSS-----SHTIVLSVCLSATPGGKE 185
QV F + ++F++YT++ + ++ V S + C + G
Sbjct: 218 LSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGAL 277
Query: 186 HLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLL 245
H W++L+ ++ C + G + + ++ + T+ I LE EK +ER++
Sbjct: 278 H--WELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIH 335
Query: 246 SLLPAHIAMEMKAEIIQRLQG---------PKAGQMENTNN-----FHNLYVKRHTNVSI 291
S++P IA ++ + + + PK + +++ F +++ VSI
Sbjct: 336 SVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSI 395
Query: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
L+ADIVGFT+++++ S LV +LN+LFG+FD++ +E +C +I LGDCYYCV+G P
Sbjct: 396 LFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPR 455
Query: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
+HA C++MGL M +AI++ +NMRVGVH+G VLCG++G++++++DVWS+DV
Sbjct: 456 ADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVN 515
Query: 412 LANHMEAGGVPGRVHISSVTLEHLNGAYKVEEG 444
LAN ME GV G+VHIS T ++L+ Y++E+G
Sbjct: 516 LANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
Score = 79.0 bits (193), Expect = 2e-14
Identities = 47/170 (27%), Positives = 81/170 (47%), Gaps = 18/170 (10%)
Query: 881 QSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKT 940
Q + V ++FA I F T+ NK + LLN++ FD L + K EKI T
Sbjct: 388 QQIEEVSILFADIVGF----TKMSANKSAHALVGLLNDLFGRFDRLCEETK---CEKIST 440
Query: 941 IGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVG 1000
+G Y G PE + H +E ++ ++ + +RVG
Sbjct: 441 LGDCYYCVAGC-----------PEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVG 489
Query: 1001 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVL 1050
++ G V+ G++G ++ ++D+W N VN+A+ M+ GV K+ ++E T+ L
Sbjct: 490 VHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYL 539
Score = 78.2 bits (191), Expect = 4e-14
Identities = 69/294 (23%), Positives = 123/294 (41%), Gaps = 35/294 (11%)
Query: 195 VIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAM 254
V++F L + E++ + Y R K++ + Q + LL +++P H+A
Sbjct: 983 VLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAE 1042
Query: 255 EMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPG--ELV 312
++K Y K H + +++A IV F+ + G E
Sbjct: 1043 QLKVS--------------------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECY 1082
Query: 313 HMLNELFGKFDQIAKE---NECMRIKILGDCYYCVSGLPISLP---NHAKNCVKMGLDMC 366
+LNEL G FD++ + + +IK +G Y SGL + +H + +++ +
Sbjct: 1083 RVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFA 1142
Query: 367 EAIKKVRDATG-----VDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGV 421
+ + +V D + +RVG + G + GVIG K YD+W V +A+ M+ GV
Sbjct: 1143 KEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGV 1202
Query: 422 PGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQH 475
R+ +S + L+ + G + Q +KTY R PQH
Sbjct: 1203 ECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQ--MKTYLYPKCTDHRVIPQH 1254
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 122 bits (306), Expect = 2e-27
Identities = 67/200 (33%), Positives = 111/200 (55%), Gaps = 21/200 (10%)
Query: 233 LEFEKRQQERLLLSLLPAHIAMEM-KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSI 291
LE EK++ LL S+ P +A ++ + +++Q K+ +NV++
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ--------------------AKKFSNVTM 482
Query: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
L++DIVGFT + S CSP +++ MLN L+ +FDQ E + +++ +GD Y GL
Sbjct: 483 LFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES 542
Query: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
HA M L M E +V G I MR+G+HSG+V GV+G++ +Y ++ ++VT
Sbjct: 543 DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 602
Query: 412 LANHMEAGGVPGRVHISSVT 431
LAN E+ VP ++++S T
Sbjct: 603 LANKFESCSVPRKINVSPTT 622
Score = 64.7 bits (156), Expect = 5e-10
Identities = 52/206 (25%), Positives = 96/206 (46%), Gaps = 27/206 (13%)
Query: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
E E+ +T++ LL ++ P VA+ + + + + + V ++F+ I F
Sbjct: 444 EEEKKKTVD-----LLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIVGFTAIC 494
Query: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
++ L+ + +LN + FD + V K++TIG Y A GL
Sbjct: 495 SQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLH-------- 539
Query: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
+E + + I M A ++ D + K+R+G++ G V AGV+G + P+Y +
Sbjct: 540 KESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCL 596
Query: 1021 WGNTVNVASRMDSTGVLDKIQVTEET 1046
+GN V +A++ +S V KI V+ T
Sbjct: 597 FGNNVTLANKFESCSVPRKINVSPTT 622
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 122 bits (306), Expect = 2e-27
Identities = 67/200 (33%), Positives = 111/200 (55%), Gaps = 21/200 (10%)
Query: 233 LEFEKRQQERLLLSLLPAHIAMEM-KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSI 291
LE EK++ LL S+ P +A ++ + +++Q K+ +NV++
Sbjct: 208 LEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ--------------------AKKFSNVTM 247
Query: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
L++DIVGFT + S CSP +++ MLN L+ +FDQ E + +++ +GD Y GL
Sbjct: 248 LFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES 307
Query: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
HA M L M E +V G I MR+G+HSG+V GV+G++ +Y ++ ++VT
Sbjct: 308 DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 367
Query: 412 LANHMEAGGVPGRVHISSVT 431
LAN E+ VP ++++S T
Sbjct: 368 LANKFESCSVPRKINVSPTT 387
Score = 65.5 bits (158), Expect = 3e-10
Identities = 53/211 (25%), Positives = 99/211 (46%), Gaps = 27/211 (12%)
Query: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
E E+ +T++ LL ++ P VA+ + + + + + V ++F+ I F
Sbjct: 209 EEEKKKTVD-----LLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIVGFTAIC 259
Query: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
++ L+ + +LN + FD + V K++TIG Y A GL
Sbjct: 260 SQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLH-------- 304
Query: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
+E + + I M A ++ D + K+R+G++ G V AGV+G + P+Y +
Sbjct: 305 KESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCL 361
Query: 1021 WGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
+GN V +A++ +S V KI V+ T +L+
Sbjct: 362 FGNNVTLANKFESCSVPRKINVSPTTYRLLK 392
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 122 bits (306), Expect = 2e-27
Identities = 67/200 (33%), Positives = 111/200 (55%), Gaps = 21/200 (10%)
Query: 233 LEFEKRQQERLLLSLLPAHIAMEM-KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSI 291
LE EK++ LL S+ P +A ++ + +++Q K+ +NV++
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ--------------------AKKFSNVTM 482
Query: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
L++DIVGFT + S CSP +++ MLN L+ +FDQ E + +++ +GD Y GL
Sbjct: 483 LFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES 542
Query: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
HA M L M E +V G I MR+G+HSG+V GV+G++ +Y ++ ++VT
Sbjct: 543 DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 602
Query: 412 LANHMEAGGVPGRVHISSVT 431
LAN E+ VP ++++S T
Sbjct: 603 LANKFESCSVPRKINVSPTT 622
Score = 65.5 bits (158), Expect = 3e-10
Identities = 53/211 (25%), Positives = 99/211 (46%), Gaps = 27/211 (12%)
Query: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
E E+ +T++ LL ++ P VA+ + + + + + V ++F+ I F
Sbjct: 444 EEEKKKTVD-----LLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIVGFTAIC 494
Query: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
++ L+ + +LN + FD + V K++TIG Y A GL
Sbjct: 495 SQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLH-------- 539
Query: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
+E + + I M A ++ D + K+R+G++ G V AGV+G + P+Y +
Sbjct: 540 KESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCL 596
Query: 1021 WGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
+GN V +A++ +S V KI V+ T +L+
Sbjct: 597 FGNNVTLANKFESCSVPRKINVSPTTYRLLK 627
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 122 bits (306), Expect = 2e-27
Identities = 67/200 (33%), Positives = 111/200 (55%), Gaps = 21/200 (10%)
Query: 233 LEFEKRQQERLLLSLLPAHIAMEM-KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSI 291
LE EK++ LL S+ P +A ++ + +++Q K+ +NV++
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ--------------------AKKFSNVTM 482
Query: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
L++DIVGFT + S CSP +++ MLN L+ +FDQ E + +++ +GD Y GL
Sbjct: 483 LFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES 542
Query: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
HA M L M E +V G I MR+G+HSG+V GV+G++ +Y ++ ++VT
Sbjct: 543 DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 602
Query: 412 LANHMEAGGVPGRVHISSVT 431
LAN E+ VP ++++S T
Sbjct: 603 LANKFESCSVPRKINVSPTT 622
Score = 65.5 bits (158), Expect = 3e-10
Identities = 53/211 (25%), Positives = 99/211 (46%), Gaps = 27/211 (12%)
Query: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
E E+ +T++ LL ++ P VA+ + + + + + V ++F+ I F
Sbjct: 444 EEEKKKTVD-----LLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIVGFTAIC 494
Query: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
++ L+ + +LN + FD + V K++TIG Y A GL
Sbjct: 495 SQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLH-------- 539
Query: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
+E + + I M A ++ D + K+R+G++ G V AGV+G + P+Y +
Sbjct: 540 KESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCL 596
Query: 1021 WGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
+GN V +A++ +S V KI V+ T +L+
Sbjct: 597 FGNNVTLANKFESCSVPRKINVSPTTYRLLK 627
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 122 bits (306), Expect = 2e-27
Identities = 67/200 (33%), Positives = 111/200 (55%), Gaps = 21/200 (10%)
Query: 233 LEFEKRQQERLLLSLLPAHIAMEM-KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSI 291
LE EK++ LL S+ P +A ++ + +++Q K+ +NV++
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ--------------------AKKFSNVTM 482
Query: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
L++DIVGFT + S CSP +++ MLN L+ +FDQ E + +++ +GD Y GL
Sbjct: 483 LFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES 542
Query: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
HA M L M E +V G I MR+G+HSG+V GV+G++ +Y ++ ++VT
Sbjct: 543 DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 602
Query: 412 LANHMEAGGVPGRVHISSVT 431
LAN E+ VP ++++S T
Sbjct: 603 LANKFESCSVPRKINVSPTT 622
Score = 65.5 bits (158), Expect = 3e-10
Identities = 53/211 (25%), Positives = 99/211 (46%), Gaps = 27/211 (12%)
Query: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
E E+ +T++ LL ++ P VA+ + + + + + V ++F+ I F
Sbjct: 444 EEEKKKTVD-----LLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIVGFTAIC 494
Query: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
++ L+ + +LN + FD + V K++TIG Y A GL
Sbjct: 495 SQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLH-------- 539
Query: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
+E + + I M A ++ D + K+R+G++ G V AGV+G + P+Y +
Sbjct: 540 KESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCL 596
Query: 1021 WGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
+GN V +A++ +S V KI V+ T +L+
Sbjct: 597 FGNNVTLANKFESCSVPRKINVSPTTYRLLK 627
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 122 bits (306), Expect = 2e-27
Identities = 67/200 (33%), Positives = 111/200 (55%), Gaps = 21/200 (10%)
Query: 233 LEFEKRQQERLLLSLLPAHIAMEM-KAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSI 291
LE EK++ LL S+ P +A ++ + +++Q K+ +NV++
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQ--------------------AKKFSNVTM 482
Query: 292 LYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISL 351
L++DIVGFT + S CSP +++ MLN L+ +FDQ E + +++ +GD Y GL
Sbjct: 483 LFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES 542
Query: 352 PNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
HA M L M E +V G I MR+G+HSG+V GV+G++ +Y ++ ++VT
Sbjct: 543 DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVT 602
Query: 412 LANHMEAGGVPGRVHISSVT 431
LAN E+ VP ++++S T
Sbjct: 603 LANKFESCSVPRKINVSPTT 622
Score = 65.5 bits (158), Expect = 3e-10
Identities = 53/211 (25%), Positives = 99/211 (46%), Gaps = 27/211 (12%)
Query: 841 EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY 900
E E+ +T++ LL ++ P VA+ + + + + + V ++F+ I F
Sbjct: 444 EEEKKKTVD-----LLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIVGFTAIC 494
Query: 901 TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS 960
++ L+ + +LN + FD + V K++TIG Y A GL
Sbjct: 495 SQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLH-------- 539
Query: 961 QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI 1020
+E + + I M A ++ D + K+R+G++ G V AGV+G + P+Y +
Sbjct: 540 KESDTHAVQIALM---ALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCL 596
Query: 1021 WGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
+GN V +A++ +S V KI V+ T +L+
Sbjct: 597 FGNNVTLANKFESCSVPRKINVSPTTYRLLK 627
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 116 bits (290), Expect = 1e-25
Identities = 66/203 (32%), Positives = 114/203 (56%), Gaps = 19/203 (9%)
Query: 233 LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSIL 292
LE EK++ LL S+ P +A ++ QG + + ++ +V++L
Sbjct: 483 LEEEKKKTVDLLYSIFPGDVAQQL-------WQGQQ------------VQARKFDDVTML 523
Query: 293 YADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLP 352
++DIVGFT + + C+P +++ MLNEL+ +FD + +++ +GD Y +GL
Sbjct: 524 FSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSL 583
Query: 353 NHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTL 412
HAK M L M E ++V G I MR+G+HSG+VL GV+G++ +Y ++ ++VTL
Sbjct: 584 CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTL 643
Query: 413 ANHMEAGGVPGRVHISSVTLEHL 435
A+ E+G P R+++S T + L
Sbjct: 644 ASKFESGSHPRRINVSPTTYQLL 666
Score = 68.6 bits (166), Expect = 3e-11
Identities = 52/223 (23%), Positives = 102/223 (45%), Gaps = 23/223 (10%)
Query: 829 RLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCV 888
R+D L K ++ + +E + LL ++ P VA+ + +++ + +D V +
Sbjct: 468 RMDKL-KATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTM 522
Query: 889 MFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAA 948
+F+ I F + ++ + +LNE+ FD F + K++TIG Y A
Sbjct: 523 LFSDIVGFTAICAQCTP----MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVA 575
Query: 949 TGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIA 1008
GL + H + A ++ + + ++R+GI+ G V+A
Sbjct: 576 AGLH-----------RKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLA 624
Query: 1009 GVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQ 1051
GV+G + P+Y ++GN V +AS+ +S +I V+ T +L+
Sbjct: 625 GVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLK 667
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 113 bits (282), Expect = 1e-24
Identities = 82/261 (31%), Positives = 130/261 (49%), Gaps = 28/261 (10%)
Query: 819 VLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEEL 878
+L R +Y L+ L + + + EE E LL +LP VAE + E +
Sbjct: 801 LLLRMEQYANNLEKLVEERTQAYLEEKRKAE----ALLYQILPHSVAEQLK----RGETV 852
Query: 879 YHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKI 938
+++D V + F+ I F ES ++ + LLN++ FD ++ V K+
Sbjct: 853 QAEAFDSVTIYFSDIVGFTALSAESTP----MQVVTLLNDLYTCFDAIIDN---FDVYKV 905
Query: 939 KTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDA--INKHSFNDFK 996
+TIG YM +GL Q H+ E R A AL+ + + I + +
Sbjct: 906 ETIGDAYMVVSGLPGRNGQRHAPEIARM----------ALALLDAVSSFRIRHRPHDQLR 955
Query: 997 LRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLG-Y 1055
LR+G++ GPV AGV+G + P+Y ++G+TVN ASRM+S G KI V+ T L LG +
Sbjct: 956 LRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCF 1015
Query: 1056 TCTCRGIINVKGKGDLKTYFV 1076
RG + +KGKG ++TY++
Sbjct: 1016 QLELRGDVEMKGKGKMRTYWL 1036
Score = 112 bits (280), Expect = 2e-24
Identities = 75/248 (30%), Positives = 136/248 (54%), Gaps = 34/248 (13%)
Query: 236 EKRQQERLLLSLLPAHIAMEMK-AEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYA 294
EKR+ E LL +LP +A ++K E +Q + +V+I ++
Sbjct: 826 EKRKAEALLYQILPHSVAEQLKRGETVQ--------------------AEAFDSVTIYFS 865
Query: 295 DIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLP-ISLPN 353
DIVGFT L+++ +P ++V +LN+L+ FD I + +++ +GD Y VSGLP +
Sbjct: 866 DIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQR 925
Query: 354 HAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
HA +M L + +A+ ++R + +R+GVH+G V GV+GL+ +Y ++ V
Sbjct: 926 HAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVN 985
Query: 412 LANHMEAGGVPGRVHISSVTLEHLN--GAYKVE-EGDGDIRDPYLKQHLVKTYFVINPKG 468
A+ ME+ G ++H+SS T + L+ G +++E GD +++ + ++TY+++ G
Sbjct: 986 TASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKG----KGKMRTYWLL---G 1038
Query: 469 ERRSPQHL 476
ER+ P L
Sbjct: 1039 ERKGPPGL 1046
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 113 bits (282), Expect = 1e-24
Identities = 84/268 (31%), Positives = 133/268 (49%), Gaps = 28/268 (10%)
Query: 819 VLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEEL 878
+L R +Y L+ L + + + EE E LL +LP VAE + E +
Sbjct: 816 LLSRMEQYANNLEELVEERTQAYLEEKRKAE----ALLYQILPHSVAEQLK----RGETV 867
Query: 879 YHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKI 938
+++D V + F+ I F ES ++ + LLN++ FD ++ V K+
Sbjct: 868 QAEAFDSVTIYFSDIVGFTALSAESTP----MQVVTLLNDLYTCFDAVIDN---FDVYKV 920
Query: 939 KTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDA--INKHSFNDFK 996
+TIG YM +GL + H+ E R A AL+ + + I +
Sbjct: 921 ETIGDAYMVVSGLPVRNGRLHACEVARM----------ALALLDAVRSFRIRHRPQEQLR 970
Query: 997 LRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTL-GY 1055
LR+GI+ GPV AGV+G + P+Y ++G+TVN ASRM+S G KI ++ ET VL+ G+
Sbjct: 971 LRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGF 1030
Query: 1056 TCTCRGIINVKGKGDLKTYFVNTEMSRS 1083
RG + +KGKG ++TY++ E S
Sbjct: 1031 ELELRGDVEMKGKGKVRTYWLLGERGSS 1058
Score = 110 bits (274), Expect = 9e-24
Identities = 70/240 (29%), Positives = 128/240 (53%), Gaps = 31/240 (12%)
Query: 236 EKRQQERLLLSLLPAHIAMEMK-AEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYA 294
EKR+ E LL +LP +A ++K E +Q + +V+I ++
Sbjct: 841 EKRKAEALLYQILPHSVAEQLKRGETVQ--------------------AEAFDSVTIYFS 880
Query: 295 DIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPN- 353
DIVGFT L+++ +P ++V +LN+L+ FD + + +++ +GD Y VSGLP+
Sbjct: 881 DIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRL 940
Query: 354 HAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVT 411
HA +M L + +A++ ++R + +R+G+H+G V GV+GL+ +Y ++ V
Sbjct: 941 HACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVN 1000
Query: 412 LANHMEAGGVPGRVHISSVT---LEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKG 468
A+ ME+ G ++H+SS T LE G GD +++ + V+TY+++ +G
Sbjct: 1001 TASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKG----KGKVRTYWLLGERG 1056
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 113 bits (282), Expect = 1e-24
Identities = 78/261 (29%), Positives = 138/261 (52%), Gaps = 31/261 (11%)
Query: 216 LQQTYQDTCNCIKSRIK-LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMEN 274
L+Q + + I+ R + LE EK++ E+LL +LP +A +K +G
Sbjct: 828 LEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEG-------- 879
Query: 275 TNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRI 334
V++ ++DIVGFT +++ P E+V +LN+L+ FD I ++ ++
Sbjct: 880 -----------FDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKV 928
Query: 335 KILGDCYYCVSGLP-ISLPNHAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNV 391
+ +GD Y SGLP + HA M LD+ ++ K+R V + +R+G+HSG V
Sbjct: 929 ETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPV 988
Query: 392 LCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVT---LEHLNGAYKVE-EGDGD 447
+ GV+GL +Y ++ V A+ ME+ G+P R+H+S T L++L+ Y+VE G +
Sbjct: 989 VAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTE 1048
Query: 448 IRDPYLKQHLVKTYFVINPKG 468
++ ++ T+++I KG
Sbjct: 1049 LKGKGTEE----TFWLIGKKG 1065
Score = 107 bits (266), Expect = 8e-23
Identities = 77/240 (32%), Positives = 120/240 (50%), Gaps = 21/240 (8%)
Query: 839 KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKE 898
++ EE+E + LL +LP VAE K + + +D V + F+ I F
Sbjct: 840 RERTEELEIEKQKTEKLLTQMLPPSVAESLK----KGCTVEPEGFDLVTLYFSDIVGF-- 893
Query: 899 FYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE 958
T E +E + LLN++ FD ++ V K++TIG YM A+GL
Sbjct: 894 --TTISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPKRNGSR 948
Query: 959 HSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQY 1018
H+ E I M + VG + ++R+G++ GPV+AGV+G P+Y
Sbjct: 949 HAAE-------IANMSLDILSSVGTFKMRHMPEV-PVRIRIGLHSGPVVAGVVGLTMPRY 1000
Query: 1019 DIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTL--GYTCTCRGIINVKGKGDLKTYFV 1076
++G+TVN ASRM+STG+ +I V+ T +LQ L GY RG +KGKG +T+++
Sbjct: 1001 CLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 107 bits (268), Expect = 5e-23
Identities = 72/234 (30%), Positives = 122/234 (52%), Gaps = 26/234 (11%)
Query: 216 LQQTYQDTCNCIKSRIK-LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMEN 274
L+Q + + I+ R + LE EK++ +RLL +LP +A +K G
Sbjct: 824 LEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKT-----------GTPVE 872
Query: 275 TNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRI 334
F V++ ++DIVGFT +++ P E+V +LN+L+ FD I ++ ++
Sbjct: 873 PEYFEQ--------VTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKV 924
Query: 335 KILGDCYYCVSGLP-ISLPNHAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNV 391
+ +GD Y SGLP + HA M LD+ A+ ++R V + +R+G+HSG
Sbjct: 925 ETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPC 984
Query: 392 LCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVT---LEHLNGAYKVE 442
+ GV+GL +Y ++ V A+ ME+ G+P R+H++ T L L+ Y+VE
Sbjct: 985 VAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
Score = 100 bits (249), Expect = 8e-21
Identities = 76/240 (31%), Positives = 117/240 (48%), Gaps = 21/240 (8%)
Query: 839 KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKE 898
++ EE+E + LL +LP VAE + E + Q V + F+ I F
Sbjct: 836 RERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDIVGF-- 889
Query: 899 FYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQE 958
T E +E + LLN++ FD ++ V K++TIG YM A+GL Q
Sbjct: 890 --TTISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPQRNGQR 944
Query: 959 HSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQY 1018
H+ E I M + VG + ++R+G++ GP +AGV+G P+Y
Sbjct: 945 HAAE-------IANMSLDILSAVGTFRMRHMPEV-PVRIRIGLHSGPCVAGVVGLTMPRY 996
Query: 1019 DIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTL--GYTCTCRGIINVKGKGDLKTYFV 1076
++G+TVN ASRM+STG+ +I V T +L+ L GY RG +KGKG T+++
Sbjct: 997 CLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWL 1056
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 100 bits (248), Expect = 1e-20
Identities = 62/206 (30%), Positives = 110/206 (53%), Gaps = 27/206 (13%)
Query: 233 LEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSIL 292
LE EK++ + LL S+LP +A E++ + + KR+ NV+IL
Sbjct: 383 LEDEKKKTDTLLYSVLPPSVANELRHK-------------------RPVPAKRYDNVTIL 423
Query: 293 YADIVGFTRLASDCSPGE----LVHMLNELFGKFDQIAKENE---CMRIKILGDCYYCVS 345
++ IVGF S + GE +V++LN+L+ +FD + + +++ +GD Y VS
Sbjct: 424 FSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVS 483
Query: 346 GLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDV 405
GLP +HA++ + LDM E +V+ G + + +G+H+G V+ GVIG + +Y +
Sbjct: 484 GLPEPCIHHARSICHLALDMMEIAGQVQ-VDGESVQITIGIHTGEVVTGVIGQRMPRYCL 542
Query: 406 WSHDVTLANHMEAGGVPGRVHISSVT 431
+ + V L + E G G++++S T
Sbjct: 543 FGNTVNLTSRTETTGEKGKINVSEYT 568
Score = 89.0 bits (219), Expect = 2e-17
Identities = 75/271 (27%), Positives = 133/271 (49%), Gaps = 27/271 (9%)
Query: 817 LLVLGRQ--NEYYCRLDF-LWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSL 873
L++LG Q EY + + ++ + +E + LL +VLP VA +
Sbjct: 352 LVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHK-- 409
Query: 874 KNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFS 933
+ + YD V ++F+ I F F ++ + ++ + LLN++ FD L K
Sbjct: 410 --RPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNP 467
Query: 934 GVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGT-MVEFAFALVGKLDAINKHSF 992
V K++T+G YM +GL P H+ R H+ M+E A G++ +
Sbjct: 468 FVYKVETVGDKYMTVSGLPE-PCIHHA----RSICHLALDMMEIA----GQVQVDGE--- 515
Query: 993 NDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQT 1052
++ +GI+ G V+ GVIG + P+Y ++GNTVN+ SR ++TG KI V+E T L +
Sbjct: 516 -SVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMS 574
Query: 1053 -----LGYTCTCRGIINVKGKGD-LKTYFVN 1077
+ RG +++KGK + ++ +F++
Sbjct: 575 PENSDPQFHLEHRGPVSMKGKKEPMQVWFLS 605
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 99.0 bits (245), Expect = 2e-20
Identities = 52/150 (34%), Positives = 89/150 (59%), Gaps = 3/150 (2%)
Query: 286 HTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVS 345
+ V+I ++DIVGFT + +P E+V MLN+++ FD I ++ +++ +GD Y S
Sbjct: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879
Query: 346 GLPISLPN-HAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNVLCGVIGLQKWQ 402
GLP N HA + KM L++ + ++ G+ I +R+GVHSG GV+G++ +
Sbjct: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939
Query: 403 YDVWSHDVTLANHMEAGGVPGRVHISSVTL 432
Y ++ V A+ ME+ G+P R+H+S T+
Sbjct: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTI 969
Score = 86.7 bits (213), Expect = 1e-16
Identities = 71/258 (27%), Positives = 126/258 (48%), Gaps = 26/258 (10%)
Query: 822 RQNEYYCR-LDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYH 880
R+ + Y R L+ L + + + + E + + LN +LL P V + + ELY
Sbjct: 766 RRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLL----PRLVVKSLKEKGFVEPELYE 821
Query: 881 QSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKT 940
+ V + F+ I F S +E + +LN+I FD ++ V K++T
Sbjct: 822 E----VTIYFSDIVGFTTICKYSTP----MEVVDMLNDIYKSFDHIVDH---HDVYKVET 870
Query: 941 IGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVG 1000
IG YM A+GL H+ + + + I + +G + + + +R+G
Sbjct: 871 IGDAYMVASGLPKRNGNRHAIDIAKMALEI-------LSFMGTFELEHLPGLPIW-IRIG 922
Query: 1001 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQ--TLGYTCT 1058
++ GP AGV+G + P+Y ++G+TVN ASRM+STG+ +I V+ T +L+ +
Sbjct: 923 VHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYE 982
Query: 1059 CRGIINVKGKGDLKTYFV 1076
RG +KG+G+ TY++
Sbjct: 983 VRGETYLKGRGNETTYWL 1000
>gi|209976994 adenylate cyclase 10 [Homo sapiens]
Length = 1610
Score = 38.9 bits (89), Expect = 0.027
Identities = 33/104 (31%), Positives = 45/104 (43%), Gaps = 13/104 (12%)
Query: 338 GDCYYCVSGLP-ISLPN---HAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLC 393
G + CV G P +P+ HA C D C + K++ + +GV SG V C
Sbjct: 341 GCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVS-------IGVASGIVFC 393
Query: 394 GVIG-LQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLN 436
G++G + +Y V V LA M PG V SVT N
Sbjct: 394 GIVGHTVRHEYTVIGQKVNLAARMMM-YYPGIVTCDSVTYNGSN 436
>gi|24308169 dynein, axonemal, heavy chain 3 [Homo sapiens]
Length = 4116
Score = 32.0 bits (71), Expect = 3.3
Identities = 23/73 (31%), Positives = 40/73 (54%), Gaps = 10/73 (13%)
Query: 815 ITLLVLGRQNEYYCRL-----DFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFL 869
+ +LV ++N+YYC L D++ + +++R I E++ R+ + V+ A V H +
Sbjct: 276 MVVLVQEKENDYYCSLMKSIVDYILMDPMERKRLFI---ESIPRLFPQRVIRAPVPWHSV 332
Query: 870 ARSLK--NEELYH 880
RS K NEE H
Sbjct: 333 YRSAKKWNEEHLH 345
>gi|6912278 COMM domain containing 3 [Homo sapiens]
Length = 195
Score = 32.0 bits (71), Expect = 3.3
Identities = 32/143 (22%), Positives = 56/143 (39%), Gaps = 16/143 (11%)
Query: 195 VIIFICGNLAGAY----HKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPA 250
V++ C A Y KH + + TY + C + RI+L + Q + L +L
Sbjct: 57 VVLKHCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLG 116
Query: 251 HIAMEMK--AEIIQRLQGPKAGQMENTNNFHNLYVKRH-TNVSILYADIVGFTRLASDCS 307
I + ++ RL+ TN H +Y + +S+ D + ++ CS
Sbjct: 117 SIGRSLPHITDVSWRLE-----YQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCS 171
Query: 308 PGELVHMLNELFGKFDQIAKENE 330
+ L +L GK +K E
Sbjct: 172 ----MEQLQDLVGKLKDASKSLE 190
>gi|5803173 solute carrier family 20, member 2 [Homo sapiens]
Length = 652
Score = 32.0 bits (71), Expect = 3.3
Identities = 24/55 (43%), Positives = 30/55 (54%), Gaps = 5/55 (9%)
Query: 596 ALPAFKYYVTCACLIFFCIFI---VQILVLPKTSVLGISFGAAFLLLAFI-LFVC 646
ALP F Y T A +F ++ V LVLP ++ ISFG A L F+ LFVC
Sbjct: 182 ALPVF-YAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVC 235
>gi|239746595 PREDICTED: hypothetical protein XP_002343793 [Homo
sapiens]
Length = 663
Score = 31.2 bits (69), Expect = 5.6
Identities = 24/66 (36%), Positives = 31/66 (46%), Gaps = 11/66 (16%)
Query: 386 VHSGNVLCG----VIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKV 441
VH VL G V+GL++W + V L +EA GVP V LEHL G ++
Sbjct: 166 VHVAAVLVGRQVLVLGLRRWPHQHHPVAVILVGGVEAHGVP-------VLLEHLKGKCRL 218
Query: 442 EEGDGD 447
GD
Sbjct: 219 LFPFGD 224
>gi|46240864 sperm associated antigen 17 [Homo sapiens]
Length = 2223
Score = 31.2 bits (69), Expect = 5.6
Identities = 32/139 (23%), Positives = 52/139 (37%), Gaps = 21/139 (15%)
Query: 834 WKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASI 893
WK K K R+EIET +N + ++P +LY Y+ + + +
Sbjct: 1882 WKEKIDKTRKEIETTQNYLMDIKNRIIPPFFKSEL-------NQLYQSQYNHLDSLSKKL 1934
Query: 894 PDFKEFYTESDVNKEGLECLRLLN---------EIIADFDDLLSKPKFSGVEKIKTIGST 944
P F + D N+ ++ LN E + L KP+ S +K T +
Sbjct: 1935 PSFTK--KNEDANETAVQDTSDLNLDFKPHKVSEQKSSSVPSLPKPEISADKKDFTAQN- 1991
Query: 945 YMAATGLSAVPSQEHSQEP 963
L+ P + S EP
Sbjct: 1992 --QTENLTKSPEEAESYEP 2008
>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
Length = 829
Score = 30.8 bits (68), Expect = 7.3
Identities = 28/129 (21%), Positives = 57/129 (44%), Gaps = 11/129 (8%)
Query: 74 DHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSP 133
DH + +TVP +A F + +L+ + L F L++ + + +G L G ++
Sbjct: 634 DHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVL-----GLMTL 688
Query: 134 WDQVSFFLFIIFVVYTM-LPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQIL 192
W+ + I+ ++YT+ + ++ + + ++ HT + S G IL
Sbjct: 689 WNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGT-----AIL 743
Query: 193 ANVIIFICG 201
NV F+ G
Sbjct: 744 QNVTSFLIG 752
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.138 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,812,359
Number of Sequences: 37866
Number of extensions: 1654803
Number of successful extensions: 5568
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 5400
Number of HSP's gapped (non-prelim): 64
length of query: 1091
length of database: 18,247,518
effective HSP length: 113
effective length of query: 978
effective length of database: 13,968,660
effective search space: 13661349480
effective search space used: 13661349480
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.