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Search of human proteins with 194097389
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194097389 kelch-like 38 [Homo sapiens]
(581 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194097389 kelch-like 38 [Homo sapiens] 1174 0.0
gi|40018614 DRE1 protein [Homo sapiens] 302 5e-82
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 286 3e-77
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 286 3e-77
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 267 2e-71
gi|109150407 kelch-like 6 [Homo sapiens] 262 7e-70
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 244 1e-64
gi|55925608 kelch-like 21 [Homo sapiens] 244 1e-64
gi|166235129 kelch-like 3 [Homo sapiens] 236 6e-62
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 234 1e-61
gi|40807500 kelch-like 20 [Homo sapiens] 224 2e-58
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 223 4e-58
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 223 4e-58
gi|128485503 kelch-like 30 [Homo sapiens] 222 6e-58
gi|11056006 kelch-like 12 [Homo sapiens] 219 5e-57
gi|38194229 kelch-like 17 [Homo sapiens] 218 1e-56
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 215 1e-55
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 215 1e-55
gi|14780904 kelch-like 1 protein [Homo sapiens] 207 2e-53
gi|40255071 kelch-like 23 [Homo sapiens] 207 3e-53
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 202 9e-52
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 202 9e-52
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 196 4e-50
gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 196 6e-50
gi|148664209 kelch-like 10 [Homo sapiens] 194 1e-49
gi|34101268 kelch-like 8 [Homo sapiens] 189 8e-48
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 185 1e-46
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 185 1e-46
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 184 3e-46
gi|55925604 kelch-like 18 [Homo sapiens] 182 1e-45
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 1174 bits (3036), Expect = 0.0
Identities = 581/581 (100%), Positives = 581/581 (100%)
Query: 1 MDEESLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFR 60
MDEESLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFR
Sbjct: 1 MDEESLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFR 60
Query: 61 AMFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLF 120
AMFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLF
Sbjct: 61 AMFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLF 120
Query: 121 EACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALEL 180
EACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALEL
Sbjct: 121 EACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALEL 180
Query: 181 RDYLGDDGLCGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDA 240
RDYLGDDGLCGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDA
Sbjct: 181 RDYLGDDGLCGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDA 240
Query: 241 LLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTR 300
LLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTR
Sbjct: 241 LLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTR 300
Query: 301 DVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKL 360
DVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKL
Sbjct: 301 DVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKL 360
Query: 361 NQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVG 420
NQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVG
Sbjct: 361 NQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVG 420
Query: 421 VLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGER 480
VLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGER
Sbjct: 421 VLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGER 480
Query: 481 IVIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDS 540
IVIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDS
Sbjct: 481 IVIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDS 540
Query: 541 ASFDCYDPETDTWTSQGQLPHKLFDHACLTLQCIPRTSGLP 581
ASFDCYDPETDTWTSQGQLPHKLFDHACLTLQCIPRTSGLP
Sbjct: 541 ASFDCYDPETDTWTSQGQLPHKLFDHACLTLQCIPRTSGLP 581
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 302 bits (774), Expect = 5e-82
Identities = 194/579 (33%), Positives = 295/579 (50%), Gaps = 25/579 (4%)
Query: 1 MDEESLDGLLFKDHDFSS----DLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSS 56
MD +SL G F D S ++L+ N R SR+ TDV IC +E PCHR VL++ S
Sbjct: 29 MDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACS 88
Query: 57 PYFRAMFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQF 116
YFRAMFC+ RE E V++ GI ++ + YVYTG+ I T+NV + E +S+ Q
Sbjct: 89 SYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQI 148
Query: 117 PKLFEACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELC 176
L +AC+ +L+ QL P NCLG+ R ++ S +TL K + AL +F +V+ + EL
Sbjct: 149 SVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELD 208
Query: 177 ALELRDYL-GDDGLCGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHF 235
EL DY+ D+ + G+EE VFEA+M W+ + R+ + EL VRL +HP +F
Sbjct: 209 KDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQT 268
Query: 236 IANDALLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNS--YQDFLILLGG-R 292
+ D L+Q+SP C +L A+R + + G + + PR S Y + ++++GG
Sbjct: 269 VEVDQLIQNSPECYQLLHEARR--YHILGNEM----MSPRTRPRRSTGYSEVIVVVGGCE 322
Query: 293 KDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHN 352
+ Y TG+W+SLAKLP A+ R+ + VS GR + S +
Sbjct: 323 RVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRN-----DILVSGGR-INSRD 376
Query: 353 VYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWE 412
V+I++ +LN W + R+ H+ ++ +GG +GQ + S+E YDS N W
Sbjct: 377 VWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGY-DGQNRLSSVECYDSFSNRWT 435
Query: 413 SMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCA 472
+A + V PAV +L++ GG +Q Y NSW I C
Sbjct: 436 EVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCI 495
Query: 473 PAVVLGERIVIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLT 532
AV L I + GG T+ I YDP + ++ + R+ + G +V K+Y+ GGRR
Sbjct: 496 TAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRE- 554
Query: 533 TDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHACLTL 571
N E + + CYDP T T +P + H C+T+
Sbjct: 555 ---NGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTI 590
Score = 30.8 bits (68), Expect = 3.6
Identities = 13/47 (27%), Positives = 25/47 (53%)
Query: 286 LILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHR 332
+ +LGGR+++ + T +L Y T +A +P + +T+HR
Sbjct: 546 IYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHR 592
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 286 bits (733), Expect = 3e-77
Identities = 185/580 (31%), Positives = 294/580 (50%), Gaps = 34/580 (5%)
Query: 11 FKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREK 70
F D ++L++LN R+++ TD+ I RE H+NVLAS S YF+ + S ++
Sbjct: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
Query: 71 SEA-----KVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSS 125
+ ++ L + L+ ++ +VYTG I + N ++EAAS QF + C S
Sbjct: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
Query: 126 YLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLG 185
+L+ QL SNCLG++ ++E + C L A+ AL FPEVAA ++ + + Y+
Sbjct: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
Query: 186 DDGL-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQS 244
+D L EE V+E ++ WIK D R +Y EL VRL +IHP++ + + N+ L++S
Sbjct: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
Query: 245 SPACQIILETAKRQMFSLCGTTVPDCKLLLHVP---PRNS--YQDFLILLGGRKDSQQTT 299
S AC+ ++ AKR +P + + P PR S + ++L+GGR+ T
Sbjct: 546 SEACRDLVNEAKRYHM------LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
Query: 300 RD---VLLYSKQTGQWQSLAKLPTRLYKA---SAITLHRSIYVLGGMAVSSGRSLVSHNV 353
R V ++ Q +W LA LP Y S ++ +IY+ GGM SG +L +V
Sbjct: 600 RSLVAVTCWNPQNNKWYPLASLP--FYDREFFSVVSAGDNIYLSGGM--ESGVTLA--DV 653
Query: 354 YIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWES 413
+ + L+ W L M V R H S + I+++GG+G + +ERYD+I N WE+
Sbjct: 654 WCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGN-VDHVERYDTITNQWEA 712
Query: 414 MASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAP 473
+A +P V A V ++Y+FGG + ++Q Y N+W +E+ MI N AP
Sbjct: 713 VAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAP 772
Query: 474 AVVLGERIVIVGG-YTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLT 532
AV L + I+GG Y R YDP+ +M R A V+ K+Y TGG
Sbjct: 773 AVTLNGFVFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGG---I 829
Query: 533 TDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHACLTLQ 572
+ + Y+P T+TWT +P +F H C+ ++
Sbjct: 830 VSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIK 869
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 286 bits (733), Expect = 3e-77
Identities = 185/580 (31%), Positives = 294/580 (50%), Gaps = 34/580 (5%)
Query: 11 FKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREK 70
F D ++L++LN R+++ TD+ I RE H+NVLAS S YF+ + S ++
Sbjct: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
Query: 71 SEA-----KVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSS 125
+ ++ L + L+ ++ +VYTG I + N ++EAAS QF + C S
Sbjct: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
Query: 126 YLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLG 185
+L+ QL SNCLG++ ++E + C L A+ AL FPEVAA ++ + + Y+
Sbjct: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
Query: 186 DDGL-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQS 244
+D L EE V+E ++ WIK D R +Y EL VRL +IHP++ + + N+ L++S
Sbjct: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
Query: 245 SPACQIILETAKRQMFSLCGTTVPDCKLLLHVP---PRNS--YQDFLILLGGRKDSQQTT 299
S AC+ ++ AKR +P + + P PR S + ++L+GGR+ T
Sbjct: 546 SEACRDLVNEAKRYHM------LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
Query: 300 RD---VLLYSKQTGQWQSLAKLPTRLYKA---SAITLHRSIYVLGGMAVSSGRSLVSHNV 353
R V ++ Q +W LA LP Y S ++ +IY+ GGM SG +L +V
Sbjct: 600 RSLVAVTCWNPQNNKWYPLASLP--FYDREFFSVVSAGDNIYLSGGM--ESGVTLA--DV 653
Query: 354 YIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWES 413
+ + L+ W L M V R H S + I+++GG+G + +ERYD+I N WE+
Sbjct: 654 WCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGN-VDHVERYDTITNQWEA 712
Query: 414 MASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAP 473
+A +P V A V ++Y+FGG + ++Q Y N+W +E+ MI N AP
Sbjct: 713 VAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAP 772
Query: 474 AVVLGERIVIVGG-YTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLT 532
AV L + I+GG Y R YDP+ +M R A V+ K+Y TGG
Sbjct: 773 AVTLNGFVFILGGAYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGG---I 829
Query: 533 TDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHACLTLQ 572
+ + Y+P T+TWT +P +F H C+ ++
Sbjct: 830 VSSEGPALGNMEAYEPTTNTWTLLPHMPCPVFRHGCVVIK 869
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 267 bits (683), Expect = 2e-71
Identities = 187/588 (31%), Positives = 284/588 (48%), Gaps = 50/588 (8%)
Query: 5 SLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFC 64
S++ LF +L LN+LR+ + TDV++ AG R PCHR VLA+SS YF AMF
Sbjct: 17 SMNVTLFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFS 76
Query: 65 SSFREKSEAKVQLK-GIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEAC 123
RE + V + + P L+ ++ + Y+ I +N ++EA MLQF + +A
Sbjct: 77 HGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAA 136
Query: 124 SSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDY 183
+ +L+ L PSNCLGM+ LS+ C L + + + L F V S D L L D
Sbjct: 137 AEFLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDL 196
Query: 184 LGDDGLCGEEEK-VFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALL 242
+ D L E+E+ VFEA++ W+KHDL+ RK ++ EL + VRL + ++++ALL
Sbjct: 197 ISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALL 256
Query: 243 QSSPACQIILETA---KRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTT 299
+ ++I++ A K ++ G C PR + LIL G QT
Sbjct: 257 MADERTKLIMDEALRCKTRILQNDGVVTSPC-----ARPRKAGHTLLILGG------QTF 305
Query: 300 RDVLLYSKQTGQWQSLAK--LPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFS 357
+Y + + K LP+ + SA + +YV GG +G VS +V+++
Sbjct: 306 MCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENG---VSKDVWVYD 362
Query: 358 LKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGG--------IGEGQELMGSMERYDSICN 409
+W PML+AR+ H S +N ++ +GG + +E+YD N
Sbjct: 363 TVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGAN 422
Query: 410 VWESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKN 469
W +A + GV + AV +L++FGG I ++ V +Q Y S N W IK
Sbjct: 423 KWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRW------TIKA 476
Query: 470 VC------APAVVLGERIVIVGGYTRRILA----YDPQSNKFVKCADMKDRRMHHGATVM 519
C A VLG +I I+GG T A +D ++N++ + DM +RM A
Sbjct: 477 ECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALAS 536
Query: 520 GNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHA 567
GNKLYV GG T C + DCYDP +DTW +P+ L A
Sbjct: 537 GNKLYVVGGYFGTQRCK-----TLDCYDPTSDTWNCITTVPYSLIPTA 579
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 262 bits (669), Expect = 7e-70
Identities = 167/574 (29%), Positives = 278/574 (48%), Gaps = 29/574 (5%)
Query: 11 FKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREK 70
F D S L L +LR LTDV +C +E CHR VLA++S YFRAMFC+ +EK
Sbjct: 49 FDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEK 108
Query: 71 SEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQ 130
E ++ +KG+D T+ ++ Y YT +A I NV V+EAA++ QF ++ +AC+S+L
Sbjct: 109 YEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEA 168
Query: 131 LAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYL-GDDGL 189
L P NC+G++RL++ S ++LKK+ + + +F ++ S + +L L L DD
Sbjct: 169 LNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLY 228
Query: 190 CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQ 249
EE +VFE +M W++H R + + + VRL + P +F + D L++ P
Sbjct: 229 VTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVF 288
Query: 250 IILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQ-DFLILLGGRKDSQQTTRDVLLYSKQ 308
+L+ A+ M+ L G + + P + +Q + +++GG ++ +V
Sbjct: 289 PLLQEAR--MYHLSGNEIISERT---KPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPL 343
Query: 309 TGQWQSLAKLP----------TRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSL 358
+AKLP + + + +TL +Y+ GG H+V+ ++
Sbjct: 344 RRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKE-------TQHDVWKYNS 396
Query: 359 KLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMP 418
+N+W E + + R+ H+ ++ IGG +G + + ++E YD N W A +
Sbjct: 397 SINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGF-DGLQRINNVETYDPFHNCWSEAAPLL 455
Query: 419 VGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLG 478
V V A ++LY+ GG + Q Y S N W ++ C AV
Sbjct: 456 VHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFR 515
Query: 479 ERIVIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIE 538
+RI +VGG R + AY P + + + R G N+LY+TGGR D E
Sbjct: 516 DRIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGR----DEKNE 571
Query: 539 DSASFDCYDPETDTWTSQGQLPHKLFDHACLTLQ 572
A+ C+DPE T + LP + H +T++
Sbjct: 572 VIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIR 605
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 244 bits (624), Expect = 1e-64
Identities = 173/581 (29%), Positives = 275/581 (47%), Gaps = 36/581 (6%)
Query: 5 SLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFC 64
S++ LF ++ +L LN LRQ R+ TDV + AG R PCHR VLA+ S YF AMF
Sbjct: 17 SINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFS 76
Query: 65 SSFREKSEAKVQL-KGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEAC 123
+E +++V I P L+ ++ Y Y+ I +N ++EA ML+F + +AC
Sbjct: 77 GGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDAC 136
Query: 124 SSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDY 183
+ +L+ L P+NCLGM+ LS+ C L + + + L++F + + D +L +
Sbjct: 137 AEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQL 196
Query: 184 LGDDGLCGEEEK-VFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALL 242
L + L E+E+ V+E+ + WI +DL+ R Y+ EL + VRL + + +A + L+
Sbjct: 197 LSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELI 256
Query: 243 QSSPACQIILETA---KRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTT 299
+ I+E A K ++ G C PR + L LLGG Q
Sbjct: 257 TKQRKSKEIVEEAIRCKLKILQNDGVVTSLC-----ARPRKT-GHALFLLGG----QTFM 306
Query: 300 RDVL-LYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSL 358
D L L ++ + A +P+ + SA + +Y+ GG +G VS +V+++
Sbjct: 307 CDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENG---VSKDVWVYDT 363
Query: 359 KLNQWRLGEPMLVARYSHRSTAHKNFIFSIGG--------IGEGQELMGSMERYDSICNV 410
+W PMLVAR+ H S K+ ++ +GG + +E YD N
Sbjct: 364 LHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINK 423
Query: 411 WESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNV 470
W +A + GV + AV +L+ FGG + + + +Q Y N W T
Sbjct: 424 WTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWR 483
Query: 471 CAPAVVLGERIVIVGGYTR----RILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVT 526
A VLG +I I+GG T ++ ++ ++ K D+ +RM A GNKLYV
Sbjct: 484 YTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVV 543
Query: 527 GGRRLTTDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHA 567
GG I+ + DCYDP D W S +P+ L A
Sbjct: 544 GGY-----FGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTA 579
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 244 bits (624), Expect = 1e-64
Identities = 177/578 (30%), Positives = 269/578 (46%), Gaps = 30/578 (5%)
Query: 9 LLFKDHDFSSDLLRQLNSLRQSRILTDVSI-CAGAREIPCHRNVLASSSPYFRAMFCSSF 67
L F D + LLR L+ LR R DV++ AG R+ P HR VLA++SPYFRAMF
Sbjct: 10 LPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQL 69
Query: 68 REKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYL 127
RE +V+L G+ P L ++ + YTG ++ DN P++ AA +LQFP + EAC ++L
Sbjct: 70 RESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFL 129
Query: 128 QSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDD 187
Q QL +NCL M +E SC L A+ L E+ A L+ L L YL DD
Sbjct: 130 QQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAE-QLERLPLARLLRYLRDD 188
Query: 188 GLC-GEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSP 246
GLC +EE ++ + W++ D R + +L + VRL ++ + + + L+ P
Sbjct: 189 GLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCP 248
Query: 247 ACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNS--YQDFLILLGGRKDSQQTTRDVLL 304
C +L A+ F D + PR S + L+L+GG V
Sbjct: 249 PCLRLLREARD--FQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDC 306
Query: 305 YSKQTGQWQSLAKLPTRLYKA-SAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQW 363
Y+ QTGQW+ LA+ P L S + L IYV GG S S + V+ ++ +N+W
Sbjct: 307 YNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGG----SDGSRLYDCVWRYNSSVNEW 362
Query: 364 RLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLH 423
PML AR H S+ ++ + S ERYD + WE++ M + +
Sbjct: 363 AEVAPMLKAREYHSSSVLDGLLYVVAA--------DSTERYDHTTDSWEALQPMTYPMDN 414
Query: 424 PAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIK--NVCAPAVVLGERI 481
+ RLY G + ++Q Y + W ++ + + L +
Sbjct: 415 CSTTACRGRLYAIG--SLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLM 472
Query: 482 VIVGGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSA 541
V + + Y+P N++ K M + V+G KLYV+GG D E S
Sbjct: 473 YFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGG----YDNTFELSD 528
Query: 542 SFDCYDPETDTWTSQGQLPHKLFDHACLTL--QCIPRT 577
+ YDPET W+ G+LP F H +++ Q +P+T
Sbjct: 529 VVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQT 566
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 236 bits (601), Expect = 6e-62
Identities = 160/544 (29%), Positives = 267/544 (49%), Gaps = 31/544 (5%)
Query: 24 LNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGIDPP 83
+N LR ++L DV I A EI HR VLA+ SPYF AMF E K+++K +D
Sbjct: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99
Query: 84 TLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMIRLS 143
TL +++ Y+YT E + +NV ++ AAS+LQ + + C +LQSQL P+NCLG+ +
Sbjct: 100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFA 159
Query: 144 EILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGEEEKVFEALMV 202
++ +C L ++A A FPEV + L ++ + D L EEKVFEA++
Sbjct: 160 DVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
Query: 203 WIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQ-IILETAKRQMFS 261
WI ++ + R +M +L + VRL + + + +AL++++ C+ ++E K +
Sbjct: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLP 279
Query: 262 LCGTTVPDCKLLLHVP---PRN--SYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLA 316
L D +LL+ P PR S +I++GG+ + + R V Y + +W +A
Sbjct: 280 L------DQRLLIKNPRTKPRTPVSLPKVMIVVGGQ--APKAIRSVECYDFEEDRWDQIA 331
Query: 317 KLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSH 376
+LP+R +A + + +Y +GG SL V ++ +QW M R +
Sbjct: 332 ELPSRRCRAGVVFMAGHVYAVGGF----NGSLRVRTVDVYDGVKDQWTSIASMQERRSTL 387
Query: 377 RSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLF 436
+ + ++++GG +G + S+E Y N W +A M V V + +LY
Sbjct: 388 GAAVLNDLLYAVGGF-DGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAV 446
Query: 437 GGED-IMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY-----TRR 490
GG D + + ++ Y+ + N W + + A VL ++ GG+ +
Sbjct: 447 GGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKS 506
Query: 491 ILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPET 550
+ YDP +N + + ADM R + G + LYV GG CN+ AS + Y+P T
Sbjct: 507 VEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL---ASVEYYNPVT 561
Query: 551 DTWT 554
D WT
Sbjct: 562 DKWT 565
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 234 bits (598), Expect = 1e-61
Identities = 172/556 (30%), Positives = 267/556 (48%), Gaps = 33/556 (5%)
Query: 14 HDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEA 73
H S LL+ LN LRQ L D+ + G +I H+ VLAS SPYF+AMF + EK +
Sbjct: 15 HLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENS 74
Query: 74 KVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAP 133
+V+ + ID L IV Y YTG I+ D V ++ AA++LQ + + C ++L+SQL P
Sbjct: 75 EVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDP 134
Query: 134 SNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGE 192
NC+G+ R +E C L A + +F V + + EL +L + + +D L
Sbjct: 135 GNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVAT 194
Query: 193 EEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIIL 252
EE VF AL WIK+D+Q R++Y+ +L VRL + F + L++ C+ +L
Sbjct: 195 EETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLL 254
Query: 253 ETAKRQMFSLCGTTVPDCKL----LLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQ 308
A + F +P+ +L +L PR + L +GG+ V +Y Q
Sbjct: 255 NEALKYHF------MPEHRLSHQTVLMTRPRCA-PKVLCAVGGKSGLFACLDSVEMYFPQ 307
Query: 309 TGQWQSLAKLPTRLYKASAITLHRSIYVLGGMA--VSSGRSLVSH--NVYIFSLKLNQWR 364
W LA L Y+ L + +YV+GG+A V G ++ H +V ++ N W
Sbjct: 308 NDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWT 367
Query: 365 LGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHP 424
E M +R + ++++GG +GQ + S+E+Y W+ +A M
Sbjct: 368 SLERMNESRSTLGVVVLAGELYALGGY-DGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCF 426
Query: 425 AVAVKDQRLYLFGGEDIMQNPVRL--IQVYHISRNSWFKMETRMIKNVCAPAVVLGERIV 482
A AV D +Y GG P + ++ Y S++SW + + K + V+ I
Sbjct: 427 AAAVLDGMIYAIGG----YGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIF 482
Query: 483 IVGGYT-----RRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNI 537
+VGG+ I YDP N++ C MK+ R GA V+ N LYV GG ++ N
Sbjct: 483 VVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLN- 541
Query: 538 EDSASFDCYDPETDTW 553
+ YDP +DTW
Sbjct: 542 ----TVQKYDPISDTW 553
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/99 (28%), Positives = 45/99 (45%), Gaps = 14/99 (14%)
Query: 466 MIKNVCAPAVVLGERIVIVGGYTRRILAYD------PQSNKFVKCADMKDRRMHHGATVM 519
M + CAP V+ VGG + D PQ++ ++ A + R G V+
Sbjct: 275 MTRPRCAPKVLCA-----VGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVL 329
Query: 520 GNKLYVTGGRRLTTDCNI---EDSASFDCYDPETDTWTS 555
K+YV GG + + S +C++P+T+TWTS
Sbjct: 330 DQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTS 368
Score = 40.0 bits (92), Expect = 0.006
Identities = 28/116 (24%), Positives = 51/116 (43%), Gaps = 11/116 (9%)
Query: 305 YSKQTGQWQSLAKLPTRLYKASAITLHRSIYV-LGGMAVSSGRSLVSH--NVYIFSLKLN 361
Y W+ +A + + +H + V LG + V G + VSH ++ + N
Sbjct: 452 YDPSKDSWEMVASMADK-------RIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
Query: 362 QWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASM 417
QW + PM R + N+++ +GG G + ++++YD I + W A M
Sbjct: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGG-HSGSSYLNTVQKYDPISDTWLDSAGM 559
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 224 bits (571), Expect = 2e-58
Identities = 162/554 (29%), Positives = 265/554 (47%), Gaps = 30/554 (5%)
Query: 21 LRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGI 80
L +N LR+ R L DV + GA++I HR +L++ SPYFRAMF E + +V ++ I
Sbjct: 55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI 114
Query: 81 DPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMI 140
D ++ ++ + YT + + NV ++ AA +LQ ++ EAC +L+ QL PSNCLG+
Sbjct: 115 DERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIR 174
Query: 141 RLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGEEEKVFEA 199
++ SC L + A + +F EV S + L A +L D + D L EE+VF A
Sbjct: 175 AFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNA 234
Query: 200 LMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQM 259
+M W+K+ +Q R+ + ++ + VRL + P F + +D L++S C+ +++ AK +
Sbjct: 235 VMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYL 294
Query: 260 FSLCGTTVPDCKLLLHVP---PRNSYQ--DFLILLGGRKDSQQTTRDVLLYSKQTGQWQS 314
+P + L+ P PR + + L +GG S V Y QT +W+
Sbjct: 295 L------LPQERPLMQGPRTRPRKPIRCGEVLFAVGG-WCSGDAISSVERYDPQTNEWRM 347
Query: 315 LAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLG-EPMLVAR 373
+A + R L +Y +GG SS ++V + K NQW P R
Sbjct: 348 VASMSKRRCGVGVSVLDDLLYAVGGHDGSS----YLNSVERYDPKTNQWSSDVAPTSTCR 403
Query: 374 YSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRL 433
S F++++GG +G + +ERYD N W +ASM L AVAV L
Sbjct: 404 TSVGVAVLGGFLYAVGG-QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFL 462
Query: 434 YLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY--TRRI 491
Y GG D +P+ ++ Y+ N W + + V + I VGG T +
Sbjct: 463 YAVGGSD-GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTEL 521
Query: 492 LA---YDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDP 548
+ Y+P++N++ M RR G V+ +L GG TT + + +DP
Sbjct: 522 SSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLK-----TIEVFDP 576
Query: 549 ETDTWTSQGQLPHK 562
+ +TW G + ++
Sbjct: 577 DANTWRLYGGMNYR 590
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 223 bits (568), Expect = 4e-58
Identities = 153/538 (28%), Positives = 252/538 (46%), Gaps = 19/538 (3%)
Query: 24 LNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGIDPP 83
+N LR +L DV+I A EI HR VLA+ SPYF AMF E +V++K +D
Sbjct: 50 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 109
Query: 84 TLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMIRLS 143
TL ++ YVYT E + +NV ++ AA +LQ + + C +L+SQL P NCLG+ +
Sbjct: 110 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 169
Query: 144 EILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGEEEKVFEALMV 202
++ +C L KA A F +V S + L ++ + D L EEKVFEA++
Sbjct: 170 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 229
Query: 203 WIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQMFSL 262
W+ HD R+ +M L + VRL + + + +AL+++S AC+ L A +
Sbjct: 230 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 289
Query: 263 CGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRL 322
+ + + + ++++GG+ + + R V Y + +W +A+LP+R
Sbjct: 290 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQ--APKAIRSVECYDFKEERWHQVAELPSRR 347
Query: 323 YKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHK 382
+A + + ++ +GG SL V + +QW M R + +
Sbjct: 348 CRAGMVYMAGLVFAVGGF----NGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLN 403
Query: 383 NFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLFGGED-I 441
++++GG +G + S+E Y+ N W +A M V V LY GG D
Sbjct: 404 GLLYAVGGF-DGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGA 462
Query: 442 MQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY-----TRRILAYDP 496
+ + ++ Y+ + N W + + A VL + VGG+ + + YDP
Sbjct: 463 SRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDP 522
Query: 497 QSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWT 554
+N + + ADM R + G + LYV GG CN+ AS + Y+P TD WT
Sbjct: 523 TTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL---ASVEYYNPTTDKWT 575
Score = 36.6 bits (83), Expect = 0.065
Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 9/83 (10%)
Query: 477 LGERIVIVGGYT----RRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLT 532
L + +V+VGG R + YD + ++ + A++ RR G M ++ GG +
Sbjct: 309 LPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 368
Query: 533 TDCNIEDSASFDCYDPETDTWTS 555
DS YDP D WTS
Sbjct: 369 LRVRTVDS-----YDPVKDQWTS 386
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 223 bits (568), Expect = 4e-58
Identities = 153/538 (28%), Positives = 252/538 (46%), Gaps = 19/538 (3%)
Query: 24 LNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGIDPP 83
+N LR +L DV+I A EI HR VLA+ SPYF AMF E +V++K +D
Sbjct: 46 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 105
Query: 84 TLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMIRLS 143
TL ++ YVYT E + +NV ++ AA +LQ + + C +L+SQL P NCLG+ +
Sbjct: 106 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 165
Query: 144 EILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGEEEKVFEALMV 202
++ +C L KA A F +V S + L ++ + D L EEKVFEA++
Sbjct: 166 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 225
Query: 203 WIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQMFSL 262
W+ HD R+ +M L + VRL + + + +AL+++S AC+ L A +
Sbjct: 226 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 285
Query: 263 CGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRL 322
+ + + + ++++GG+ + + R V Y + +W +A+LP+R
Sbjct: 286 TEQRILMKSVRTRLRTPMNLPKLMVVVGGQ--APKAIRSVECYDFKEERWHQVAELPSRR 343
Query: 323 YKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHK 382
+A + + ++ +GG SL V + +QW M R + +
Sbjct: 344 CRAGMVYMAGLVFAVGGF----NGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLN 399
Query: 383 NFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLFGGED-I 441
++++GG +G + S+E Y+ N W +A M V V LY GG D
Sbjct: 400 GLLYAVGGF-DGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGA 458
Query: 442 MQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY-----TRRILAYDP 496
+ + ++ Y+ + N W + + A VL + VGG+ + + YDP
Sbjct: 459 SRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDP 518
Query: 497 QSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWT 554
+N + + ADM R + G + LYV GG CN+ AS + Y+P TD WT
Sbjct: 519 TTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL---ASVEYYNPTTDKWT 571
Score = 36.6 bits (83), Expect = 0.065
Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 9/83 (10%)
Query: 477 LGERIVIVGGYT----RRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLT 532
L + +V+VGG R + YD + ++ + A++ RR G M ++ GG +
Sbjct: 305 LPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 364
Query: 533 TDCNIEDSASFDCYDPETDTWTS 555
DS YDP D WTS
Sbjct: 365 LRVRTVDS-----YDPVKDQWTS 382
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 222 bits (566), Expect = 6e-58
Identities = 164/566 (28%), Positives = 254/566 (44%), Gaps = 37/566 (6%)
Query: 20 LLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKG 79
+L L LR L DV++ G RE+PCHR +LA SSPYF AMF F E A+V+L+
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRD 60
Query: 80 IDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGM 139
++P + Q+V +VYTG I NV + A+ L FP + + C YLQ QL +NCLG+
Sbjct: 61 VEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGI 120
Query: 140 IRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGEEEKVFE 198
E + KA +F VA + +L L L D L E+ E
Sbjct: 121 CEFGEQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
Query: 199 ALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQ 258
ALM W++HD QAR ++ EL V L + +A++ L+Q S AC+ L
Sbjct: 181 ALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGH-- 238
Query: 259 MFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRD--------VLLYSKQTG 310
L L + ++ L+++GG+ ++ + Y+ +
Sbjct: 239 ---------DGAPLAL----QQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAK 285
Query: 311 QWQSLAKLPT-RLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPM 369
+W +L P + S L+ +IYV GG + + + + F LK W+ PM
Sbjct: 286 RWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPM 345
Query: 370 LVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVK 429
L R +H S A I+ IGG + +E YD + W ++ V + + A
Sbjct: 346 LKPRTNHASAALNGEIYVIGGTTLD---VVEVESYDPYTDSWTPVSPALKYVSNFSAAGC 402
Query: 430 DQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMI-KNVCAP-AVVLGERIVIVGGY 487
RLYL G N + L Q Y+ ++W + + + K + +P L + ++G
Sbjct: 403 RGRLYLVGSSACKYNALAL-QCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN 461
Query: 488 TRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGR--RLTTDCNIEDSASFDC 545
T+++ YDP +N + K + +G+ LYVTGGR + D ++E +
Sbjct: 462 TKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVE----MEA 517
Query: 546 YDPETDTWTSQGQLPHKLFDHACLTL 571
YD DTWT G LP H T+
Sbjct: 518 YDTVRDTWTRHGALPRLWLYHGASTV 543
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 219 bits (558), Expect = 5e-57
Identities = 161/556 (28%), Positives = 264/556 (47%), Gaps = 32/556 (5%)
Query: 17 SSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQ 76
+ +L +NSLR+S L DV++ ++ P HR VLA+ S YF AMF S EK + V
Sbjct: 16 AKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVD 75
Query: 77 LKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNC 136
++G+ T++ ++ +VYT H+ +NV ++ AA +LQ + +AC +L+SQL PSNC
Sbjct: 76 IQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 135
Query: 137 LGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGEEEK 195
LG+ +E +C L + A + FPEV + L E+ + D + EE
Sbjct: 136 LGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEP 195
Query: 196 VFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETA 255
VFEA++ W+KH + R+ + L + VR+ + P + I + ++ S C+ +++ A
Sbjct: 196 VFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEA 255
Query: 256 KRQMFSLCGTTVPDCKLLLHVP---PRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQW 312
K+ F L P+ + + P R + L+++GG Q V Y +T +W
Sbjct: 256 KK--FHL----RPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEW 309
Query: 313 QSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQ---WRLGEPM 369
L + + ++++LH IYV+GG GRS +S +V ++ W PM
Sbjct: 310 SFLPSITRKRRYVASVSLHDRIYVIGGY---DGRSRLS-SVECLDYTADEDGVWYSVAPM 365
Query: 370 LVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVK 429
V R +T + I+ GG +G SMERYD + W + M + V
Sbjct: 366 NVRRGLAGATTLGDMIYVSGGF-DGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVA 424
Query: 430 DQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY-- 487
+Y GG D + N + ++ Y W + K A +L + I +VGG+
Sbjct: 425 SGVIYCLGGYDGL-NILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDG 483
Query: 488 ---TRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFD 544
+ AY+ +++ + M R + GATV+ +LY G D N +S +
Sbjct: 484 TAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG----YDGN-SLLSSIE 538
Query: 545 CYDPETDTW---TSQG 557
CYDP D+W TS G
Sbjct: 539 CYDPIIDSWEVVTSMG 554
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/139 (28%), Positives = 61/139 (43%), Gaps = 21/139 (15%)
Query: 433 LYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGYTRR-- 490
L + GG Q+P+ +++ Y W + + K +V L +RI ++GGY R
Sbjct: 283 LLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSR 342
Query: 491 -----ILAYDP-QSNKFVKCADMKDRRMHHGATVMGNKLYVTGG----RRLTTDCNIEDS 540
L Y + + A M RR GAT +G+ +YV+GG RR T
Sbjct: 343 LSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHT-------- 394
Query: 541 ASFDCYDPETDTWTSQGQL 559
S + YDP D W+ G +
Sbjct: 395 -SMERYDPNIDQWSMLGDM 412
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 218 bits (555), Expect = 1e-56
Identities = 154/548 (28%), Positives = 250/548 (45%), Gaps = 29/548 (5%)
Query: 19 DLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLK 78
D ++ +RQ +L D+ + A+EI H+ VLAS SPYF AMF + E + V L
Sbjct: 77 DAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLH 136
Query: 79 GIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLG 138
IDP LDQ+V + YT E + NV ++ AAS+LQ + +AC +L SQL PSNCLG
Sbjct: 137 DIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLG 196
Query: 139 MIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL-CGEEEKVF 197
+ ++ SC L K A L F +VA + + L ++ + + D L EE+V+
Sbjct: 197 IRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVY 256
Query: 198 EALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQ-IILETAK 256
A++ W+KHD+ AR++++ L K VRL + F + ++L++ P C+ +++E K
Sbjct: 257 RAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALK 316
Query: 257 RQMFSLCGTTVPDCKLLLHV----PPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQW 312
+ +P+ + +L P R ++ G D Y +T +W
Sbjct: 317 FHL-------LPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRW 369
Query: 313 QSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVA 372
+A + TR + + +Y +GG +S + V + N W+ M
Sbjct: 370 HVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVES----YDPVTNTWQPEVSMGTR 425
Query: 373 RYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQR 432
R A ++S GG +G + S ERYD + W S+A+M + VA D
Sbjct: 426 RSCLGVAALHGLLYSAGGY-DGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGN 484
Query: 433 LYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGG-----Y 487
LY GG D + + ++ Y N W + + + + A VL + + GG
Sbjct: 485 LYAVGGYD-SSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSC 543
Query: 488 TRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYD 547
+ Y P++ + A M RR H M LY GG ++ N S + Y+
Sbjct: 544 LNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLN-----SIEKYN 598
Query: 548 PETDTWTS 555
P T+ W +
Sbjct: 599 PRTNKWVA 606
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 215 bits (547), Expect = 1e-55
Identities = 151/565 (26%), Positives = 261/565 (46%), Gaps = 36/565 (6%)
Query: 11 FKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREK 70
F+ + + +++ + + + L DV + AG R IP HR VL+S S YF AMF + RE
Sbjct: 151 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 210
Query: 71 SEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQ 130
+ +++++G++P +L ++ Y YTG + DN+ ++ A +LQ ++ EAC +L Q
Sbjct: 211 RQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQ 270
Query: 131 LAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL- 189
L PSNCLG+ ++ C L K A + F EV + + L A E+ L D +
Sbjct: 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMN 330
Query: 190 CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQ 249
EE + AL+ W++HDL+ R++ + +L +RL + P F + N+ L + CQ
Sbjct: 331 IPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQ 389
Query: 250 -IILETAKRQMFSLCGTTVPDCKLLLHVP---PRNSYQDFLILLGGRKDSQQTTRDVLLY 305
+I+E K + +P+ + +L P PR S L +GG DS + + Y
Sbjct: 390 KLIMEAMKYHL-------LPERRPMLQSPRTKPRKSTVGTLFAVGG-MDSTKGATSIEKY 441
Query: 306 SKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRL 365
+T W +A + R + L +YV+GG G + + V ++ K W +
Sbjct: 442 DLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG---RDGLKTL-NTVECYNPKTKTWSV 497
Query: 366 GEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPA 425
PM R+ + ++++GG +G + ++ER+D W +A+M
Sbjct: 498 MPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 556
Query: 426 VAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVG 485
VAV +LY GG D + ++ ++ + N W + + +G
Sbjct: 557 VAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG 615
Query: 486 GY-------TRR----ILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTD 534
G+ T R + YDP+++ + A M R G ++G+KLY GG
Sbjct: 616 GHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY 675
Query: 535 CNIEDSASFDCYDPETDTWTSQGQL 559
N + + YDP+T+ WT L
Sbjct: 676 LN-----TVEAYDPQTNEWTQVAPL 695
Score = 44.3 bits (103), Expect = 3e-04
Identities = 33/137 (24%), Positives = 61/137 (44%), Gaps = 4/137 (2%)
Query: 286 LILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGG--MAVS 343
L +GGR D + V + T +W A++ R T + +Y +GG S
Sbjct: 564 LYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 622
Query: 344 SGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMER 403
+ S +S V + K + W M ++R + + ++++GG +GQ + ++E
Sbjct: 623 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY-DGQAYLNTVEA 681
Query: 404 YDSICNVWESMASMPVG 420
YD N W +A + +G
Sbjct: 682 YDPQTNEWTQVAPLCLG 698
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 215 bits (547), Expect = 1e-55
Identities = 151/565 (26%), Positives = 261/565 (46%), Gaps = 36/565 (6%)
Query: 11 FKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREK 70
F+ + + +++ + + + L DV + AG R IP HR VL+S S YF AMF + RE
Sbjct: 197 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 256
Query: 71 SEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQ 130
+ +++++G++P +L ++ Y YTG + DN+ ++ A +LQ ++ EAC +L Q
Sbjct: 257 RQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQ 316
Query: 131 LAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL- 189
L PSNCLG+ ++ C L K A + F EV + + L A E+ L D +
Sbjct: 317 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMN 376
Query: 190 CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQ 249
EE + AL+ W++HDL+ R++ + +L +RL + P F + N+ L + CQ
Sbjct: 377 IPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQ 435
Query: 250 -IILETAKRQMFSLCGTTVPDCKLLLHVP---PRNSYQDFLILLGGRKDSQQTTRDVLLY 305
+I+E K + +P+ + +L P PR S L +GG DS + + Y
Sbjct: 436 KLIMEAMKYHL-------LPERRPMLQSPRTKPRKSTVGTLFAVGG-MDSTKGATSIEKY 487
Query: 306 SKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRL 365
+T W +A + R + L +YV+GG G + + V ++ K W +
Sbjct: 488 DLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG---RDGLKTL-NTVECYNPKTKTWSV 543
Query: 366 GEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPA 425
PM R+ + ++++GG +G + ++ER+D W +A+M
Sbjct: 544 MPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 602
Query: 426 VAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVG 485
VAV +LY GG D + ++ ++ + N W + + +G
Sbjct: 603 VAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIG 661
Query: 486 GY-------TRR----ILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTD 534
G+ T R + YDP+++ + A M R G ++G+KLY GG
Sbjct: 662 GHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY 721
Query: 535 CNIEDSASFDCYDPETDTWTSQGQL 559
N + + YDP+T+ WT L
Sbjct: 722 LN-----TVEAYDPQTNEWTQVAPL 741
Score = 44.3 bits (103), Expect = 3e-04
Identities = 33/137 (24%), Positives = 61/137 (44%), Gaps = 4/137 (2%)
Query: 286 LILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGG--MAVS 343
L +GGR D + V + T +W A++ R T + +Y +GG S
Sbjct: 610 LYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 668
Query: 344 SGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMER 403
+ S +S V + K + W M ++R + + ++++GG +GQ + ++E
Sbjct: 669 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY-DGQAYLNTVEA 727
Query: 404 YDSICNVWESMASMPVG 420
YD N W +A + +G
Sbjct: 728 YDPQTNEWTQVAPLCLG 744
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 207 bits (527), Expect = 2e-53
Identities = 160/563 (28%), Positives = 259/563 (46%), Gaps = 54/563 (9%)
Query: 22 RQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGID 81
R++ S + + L DV + G R+IP HR VL+S S YF AMF S E + +++++GID
Sbjct: 200 RKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGID 259
Query: 82 PPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMIR 141
P L +V + YTG + D + ++ AA +LQ P++ E C +L L PSNCLG+
Sbjct: 260 PNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRA 319
Query: 142 LSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYL-GDDGLCGEEEKVFEAL 200
++ C L K A + + EV + + L A EL L DD +EE +F AL
Sbjct: 320 FADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHAL 379
Query: 201 MVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQ-IILETAKRQM 259
M+W+K+D+Q+R + L +RL + P + N AL ++ CQ +ILE K +
Sbjct: 380 MMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLECQKLILEAMKYHL 438
Query: 260 FSLCGTTVPDCKLLLHVP---PRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLA 316
+P+ + L+ P PR S L +GG D+ + + Y +T W
Sbjct: 439 -------LPERRTLMQSPRTKPRKSTVGTLYAVGG-MDNNKGATTIEKYDLRTNLWIQAG 490
Query: 317 KLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSH 376
+ R + + ++V+GG G + + V ++ K W + PM R+
Sbjct: 491 MMNGRRLQFGVAVIDDKLFVIGG---RDGLKTL-NTVECYNPKTKTWTVLPPMSTHRHGL 546
Query: 377 RSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLF 436
T + I+++GG +G + ++ER+D W +ASM + VA + +LY
Sbjct: 547 GVTVLEGPIYAVGG-HDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSV 605
Query: 437 GGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAP---------AVVLGERIVIVGG- 486
GG D + + ++ Y N W N+CAP + VGG
Sbjct: 606 GGRD-GSSCLSSMEYYDPHTNKW---------NMCAPMCKRRGGVGVATCDGFLYAVGGH 655
Query: 487 ------YTRRIL----AYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCN 536
+ R+L YDP+++ + A + R G ++G++LY GG T N
Sbjct: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715
Query: 537 IEDSASFDCYDPETDTWTSQGQL 559
+S YDP+T+ WT L
Sbjct: 716 TMES-----YDPQTNEWTQMASL 733
Score = 47.8 bits (112), Expect = 3e-05
Identities = 38/148 (25%), Positives = 62/148 (41%), Gaps = 4/148 (2%)
Query: 286 LILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGG--MAVS 343
L +GGR D + Y T +W A + R T +Y +GG S
Sbjct: 602 LYSVGGR-DGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
Query: 344 SGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMER 403
+ S + V + K + W + P+ + R + + ++++GG +GQ + +ME
Sbjct: 661 NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGY-DGQTYLNTMES 719
Query: 404 YDSICNVWESMASMPVGVLHPAVAVKDQ 431
YD N W MAS+ +G V V Q
Sbjct: 720 YDPQTNEWTQMASLNIGRAGACVVVIKQ 747
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 207 bits (526), Expect = 3e-53
Identities = 152/565 (26%), Positives = 257/565 (45%), Gaps = 28/565 (4%)
Query: 10 LFKDHDFSSDLLRQLNSLRQSRILTDVSI-CAGAREIPCHRNVLASSSPYFRAMFCSSFR 68
LFKD D L + + TD+++ C CHR VLA+ S YF+AMF + +
Sbjct: 12 LFKDSTHPVDFLDAFRTFYLDGLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMK 71
Query: 69 EKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQ 128
EK + K++L GI L+ +V+Y YT + I NV ++EAA +LQF + +AC +L
Sbjct: 72 EKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKACERFLV 131
Query: 129 SQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDG 188
L NC+GM +E C L+K++R + + F EV + E+ + L
Sbjct: 132 RHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISLEKFLFILSRKN 191
Query: 189 L-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPA 247
L +EE + E ++ W HD++ R + L + + I P + + LQ S
Sbjct: 192 LSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINID-IDPVYLKTALG----LQRS-- 244
Query: 248 CQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSK 307
C + + +++ +H + ++GG +V ++
Sbjct: 245 CLLTENKIRSLIYNALNP--------MHKEISQRSTATMYIIGGY--YWHPLSEVHIWDP 294
Query: 308 QTGQWQSLAKLPTRLYKASAIT-LHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLG 366
T W A++P ++ +T L +IYV GG + +L V+I++ + ++W G
Sbjct: 295 LTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEAL--DTVWIYNSESDEWTEG 352
Query: 367 EPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAV 426
PML ARY H + ++++GG +G E YD + W +A+M GV +
Sbjct: 353 LPMLNARYYHCAVTLGGCVYALGGYRKGAP-AEEAEFYDPLKEKWIPIANMIKGVGNATA 411
Query: 427 AVKDQRLYLFGGEDIMQNPVRL--IQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIV 484
V +Y+ GG + +Q Y+ N W + + +V ++ +V
Sbjct: 412 CVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLV 471
Query: 485 GGYTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFD 544
GG T YDP+ N++ + A M +RRM GA +M +YVTGG + ++ S +
Sbjct: 472 GGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQ---SIE 528
Query: 545 CYDPETDTWTSQGQLPHKLFDHACL 569
YDP+ + W G LP + H C+
Sbjct: 529 KYDPDLNKWEIVGNLPSAMRSHGCV 553
Score = 47.8 bits (112), Expect = 3e-05
Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 8/94 (8%)
Query: 483 IVGGYTRRILA----YDPQSNKFVKCADMKD-RRMHHGATVMGNKLYVTGGRRLTTDCNI 537
I+GGY L+ +DP +N +++ A++ D R +G T +G +YVTGG R TD NI
Sbjct: 277 IIGGYYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYR--TD-NI 333
Query: 538 EDSASFDCYDPETDTWTSQGQLPHKLFDHACLTL 571
E + Y+ E+D WT + + + H +TL
Sbjct: 334 EALDTVWIYNSESDEWTEGLPMLNARYYHCAVTL 367
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 202 bits (513), Expect = 9e-52
Identities = 159/544 (29%), Positives = 241/544 (44%), Gaps = 31/544 (5%)
Query: 24 LNSLRQSRILTDVSICAGAREIPC-----HRNVLASSSPYFRAMFCSSFREKSEAKVQLK 78
+N LR S+ L DV++ ++ P H+ VLASSSP F+AMF + RE+ V ++
Sbjct: 67 MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIE 126
Query: 79 GIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLG 138
GI P +++++ + YT + VL VM A M Q + ACS +L QL PSN +G
Sbjct: 127 GIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Query: 139 MIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL---CGEEEK 195
+ +E + C L ++ARE F EVA + L +L + D L C E +
Sbjct: 187 IANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRC--ESE 244
Query: 196 VFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETA 255
VF A + W+K+D + R+ Y+Q L + VR + P F + +LQS C+ L
Sbjct: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI 304
Query: 256 KRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSL 315
++ T V C+ + GG +Q+ + Y+ G W L
Sbjct: 305 FEELTLHKPTQVMPCR-------APKVGRLIYTAGGY--FRQSLSYLEAYNPSDGTWLRL 355
Query: 316 AKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYS 375
A L + + +Y +GG S + S + ++ NQW PM V R
Sbjct: 356 ADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNR 415
Query: 376 HRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYL 435
I+++GG G S+ERY+ + W +A M + VAV ++ LY
Sbjct: 416 IGVGVIDGHIYAVGG-SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYA 474
Query: 436 FGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY-----TRR 490
GG D N + + Y+ RN W + A VL I GGY
Sbjct: 475 VGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNS 533
Query: 491 ILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPET 550
+ YD ++ + A MK RR G TV ++YV GG T + S +CYDP+T
Sbjct: 534 VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLD-----SVECYDPDT 588
Query: 551 DTWT 554
DTW+
Sbjct: 589 DTWS 592
Score = 45.8 bits (107), Expect = 1e-04
Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 5/143 (3%)
Query: 286 LILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSG 345
L+ G D Y + +W+ + + T A LH IY GG G
Sbjct: 471 LLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY---DG 527
Query: 346 RSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYD 405
+ ++ +V + ++ W PM R + T H+ I+ +GG +G + S+E YD
Sbjct: 528 QDQLN-SVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGY-DGHTFLDSVECYD 585
Query: 406 SICNVWESMASMPVGVLHPAVAV 428
+ W + M G VAV
Sbjct: 586 PDTDTWSEVTRMTSGRSGVGVAV 608
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 202 bits (513), Expect = 9e-52
Identities = 159/544 (29%), Positives = 241/544 (44%), Gaps = 31/544 (5%)
Query: 24 LNSLRQSRILTDVSICAGAREIPC-----HRNVLASSSPYFRAMFCSSFREKSEAKVQLK 78
+N LR S+ L DV++ ++ P H+ VLASSSP F+AMF + RE+ V ++
Sbjct: 67 MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIE 126
Query: 79 GIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLG 138
GI P +++++ + YT + VL VM A M Q + ACS +L QL PSN +G
Sbjct: 127 GIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Query: 139 MIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDGL---CGEEEK 195
+ +E + C L ++ARE F EVA + L +L + D L C E +
Sbjct: 187 IANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRC--ESE 244
Query: 196 VFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETA 255
VF A + W+K+D + R+ Y+Q L + VR + P F + +LQS C+ L
Sbjct: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKI 304
Query: 256 KRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSL 315
++ T V C+ + GG +Q+ + Y+ G W L
Sbjct: 305 FEELTLHKPTQVMPCR-------APKVGRLIYTAGGY--FRQSLSYLEAYNPSDGTWLRL 355
Query: 316 AKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYS 375
A L + + +Y +GG S + S + ++ NQW PM V R
Sbjct: 356 ADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNR 415
Query: 376 HRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYL 435
I+++GG G S+ERY+ + W +A M + VAV ++ LY
Sbjct: 416 IGVGVIDGHIYAVGG-SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYA 474
Query: 436 FGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY-----TRR 490
GG D N + + Y+ RN W + A VL I GGY
Sbjct: 475 VGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNS 533
Query: 491 ILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPET 550
+ YD ++ + A MK RR G TV ++YV GG T + S +CYDP+T
Sbjct: 534 VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLD-----SVECYDPDT 588
Query: 551 DTWT 554
DTW+
Sbjct: 589 DTWS 592
Score = 45.8 bits (107), Expect = 1e-04
Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 5/143 (3%)
Query: 286 LILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSG 345
L+ G D Y + +W+ + + T A LH IY GG G
Sbjct: 471 LLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY---DG 527
Query: 346 RSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYD 405
+ ++ +V + ++ W PM R + T H+ I+ +GG +G + S+E YD
Sbjct: 528 QDQLN-SVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGY-DGHTFLDSVECYD 585
Query: 406 SICNVWESMASMPVGVLHPAVAV 428
+ W + M G VAV
Sbjct: 586 PDTDTWSEVTRMTSGRSGVGVAV 608
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 196 bits (499), Expect = 4e-50
Identities = 141/527 (26%), Positives = 241/527 (45%), Gaps = 36/527 (6%)
Query: 49 RNVLASSSPYFRAMFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVM 108
R VL+S S YF AMF + RE + +++++G++P +L ++ Y YTG + DN+ ++
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 109 EAASMLQFPKLFEACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAA 168
A +LQ ++ EAC +L QL PSNCLG+ ++ C L K A + F EV
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 169 SADLKELCALELRDYLGDDGL-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYI 227
+ + L A E+ L D + EE + AL+ W++HDL+ R++ + +L +RL +
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 228 HPAFFHHFIANDALLQSSPACQ-IILETAKRQMFSLCGTTVPDCKLLLHVP---PRNSYQ 283
P F + N+ L + CQ +I+E K + +P+ + +L P PR S
Sbjct: 354 APQFLAD-MENNVLFRDDIECQKLIMEAMKYHL-------LPERRPMLQSPRTKPRKSTV 405
Query: 284 DFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVS 343
L +GG DS + + Y +T W +A + R + L +YV+GG
Sbjct: 406 GTLFAVGG-MDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG---R 461
Query: 344 SGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMER 403
G + + V ++ K W + PM R+ + ++++GG +G + ++ER
Sbjct: 462 DGLKTL-NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVER 519
Query: 404 YDSICNVWESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKME 463
+D W +A+M VAV +LY GG D + ++ ++ + N W
Sbjct: 520 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCA 578
Query: 464 TRMIKNVCAPAVVLGERIVIVGGY-------TRR----ILAYDPQSNKFVKCADMKDRRM 512
+ + +GG+ T R + YDP+++ + A M R
Sbjct: 579 QMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 638
Query: 513 HHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWTSQGQL 559
G ++G+KLY GG N + + YDP+T+ WT L
Sbjct: 639 AVGVCLLGDKLYAVGGYDGQAYLN-----TVEAYDPQTNEWTQVAPL 680
Score = 44.3 bits (103), Expect = 3e-04
Identities = 33/137 (24%), Positives = 61/137 (44%), Gaps = 4/137 (2%)
Query: 286 LILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGG--MAVS 343
L +GGR D + V + T +W A++ R T + +Y +GG S
Sbjct: 549 LYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 607
Query: 344 SGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMER 403
+ S +S V + K + W M ++R + + ++++GG +GQ + ++E
Sbjct: 608 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY-DGQAYLNTVEA 666
Query: 404 YDSICNVWESMASMPVG 420
YD N W +A + +G
Sbjct: 667 YDPQTNEWTQVAPLCLG 683
>gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 702
Score = 196 bits (497), Expect = 6e-50
Identities = 128/399 (32%), Positives = 207/399 (51%), Gaps = 29/399 (7%)
Query: 11 FKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREK 70
F D ++L++LN R+++ TD+ I RE H+NVLAS S YF+ + S ++
Sbjct: 306 FTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDS 365
Query: 71 SEA-----KVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSS 125
+ ++ L + L+ ++ +VYTG I + N ++EAAS QF + C S
Sbjct: 366 GQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVS 425
Query: 126 YLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLG 185
+L+ QL SNCLG++ ++E + C L A+ AL FPEVAA ++ + + Y+
Sbjct: 426 FLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVS 485
Query: 186 DDGL-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQS 244
+D L EE V+E ++ WIK D R +Y EL VRL +IHP++ + + N+ L++S
Sbjct: 486 NDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKS 545
Query: 245 SPACQIILETAKRQMFSLCGTTVPDCKLLLHVP---PRNS--YQDFLILLGGRKDSQQTT 299
S AC+ ++ AKR +P + + P PR S + ++L+GGR+ T
Sbjct: 546 SEACRDLVNEAKRYHM------LPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQ 599
Query: 300 RD---VLLYSKQTGQWQSLAKLPTRLYKA---SAITLHRSIYVLGGMAVSSGRSLVSHNV 353
R V ++ Q +W LA LP Y S ++ +IY+ GGM SG +L +V
Sbjct: 600 RSLVAVTCWNPQNNKWYPLASLP--FYDREFFSVVSAGDNIYLSGGM--ESGVTLA--DV 653
Query: 354 YIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIG 392
+ + L+ W L M V R H S + I+++GG+G
Sbjct: 654 WCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLG 692
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 194 bits (494), Expect = 1e-49
Identities = 152/541 (28%), Positives = 241/541 (44%), Gaps = 28/541 (5%)
Query: 25 NSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGIDPPT 84
N LR L DV I E H+N+L S S YFRA+F S + + + GI P
Sbjct: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDM 89
Query: 85 LDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMIRLSE 144
+ I+ Y YT I DNV ++ AA + C +L+S+L NC+G+ + ++
Sbjct: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
Query: 145 ILSCETLKKKAREVALTSFPE-VAASADLKELCALELRDYLGDDGL-CGEEEKVFEALMV 202
C L++KA L +F E V SA+ EL EL+D + D L +E+ VFEA++
Sbjct: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
Query: 203 WIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQMFSL 262
WI HD Q RK+++ L +VRL +H +F + + + ++ S C+ ++ A + M+ L
Sbjct: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDL 269
Query: 263 --CGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPT 320
G + D L PR Y L +GG T + Y + +W ++
Sbjct: 270 NMNGPSNSDFTNPL-TRPRLPYA-ILFAIGGWSGGSPTNA-IEAYDARADRWVNVT---- 322
Query: 321 RLYKASAITLHRSIYVLGGMAVSSGRSLVSH--NVYIFSLKLNQWRLGEPMLVARYSHRS 378
+ S H + Y+ G + + G V + +V F W PM R
Sbjct: 323 -CEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSV 381
Query: 379 TAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLFGG 438
T NFI+++GG +G + + ERY+ N W +A M + ++Y+ GG
Sbjct: 382 TVLGNFIYAMGGF-DGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGG 440
Query: 439 EDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY-----TRRILA 493
+ + +VY+ N W + + + GE + VGG+ R A
Sbjct: 441 FN-GNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEA 499
Query: 494 YDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGG-RRLTTDCNIEDSASFDCYDPETDT 552
Y P +N + M + R + G V+ + L+V GG TT N+E CYD +TD
Sbjct: 500 YSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVE------CYDEKTDE 553
Query: 553 W 553
W
Sbjct: 554 W 554
Score = 42.7 bits (99), Expect = 0.001
Identities = 33/134 (24%), Positives = 52/134 (38%), Gaps = 11/134 (8%)
Query: 444 NPVRLIQVYHISRNSWFKMETRMIK-NVCAPAVVLGERIVIVGG-----YTRRILAYDPQ 497
+P I+ Y + W + A L + I+GG Y + +DP
Sbjct: 303 SPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPV 362
Query: 498 SNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWTSQG 557
+ + A M RR + TV+GN +Y GG N + Y+PET+ WT
Sbjct: 363 KKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAER-----YEPETNQWTLIA 417
Query: 558 QLPHKLFDHACLTL 571
+ + D + TL
Sbjct: 418 PMHEQRSDASATTL 431
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 189 bits (479), Expect = 8e-48
Identities = 146/569 (25%), Positives = 249/569 (43%), Gaps = 23/569 (4%)
Query: 2 DEESLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRA 61
D + D +F+ ++ D L ++ L DV++ G++ I CH+ VLA PYFRA
Sbjct: 35 DGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRA 94
Query: 62 MFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFE 121
MF S E + ++++ D ++ +V +VY+ + DNV P++ AA +LQ +
Sbjct: 95 MFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVAR 154
Query: 122 ACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELR 181
AC Y++ PSNCL + +E + L A + A F EV D + L
Sbjct: 155 ACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLH 214
Query: 182 DYLGDDGLCGEEEK-VFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDA 240
L L E EK V+ A + W+ + Q +++ E QVRL + F +A +
Sbjct: 215 KLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQ 274
Query: 241 LLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTR 300
+++ + C+ +L+ A+ L VPD + + PR L +GGR S R
Sbjct: 275 IVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFR 334
Query: 301 DVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKL 360
+ YS W ++ +R I++ +Y +GG G + ++ +F
Sbjct: 335 SIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGG---HDGNEHLG-SMEMFDPLT 390
Query: 361 NQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASM--P 418
N+W + M R + I++IGG+ + +ERYD + W ++A M P
Sbjct: 391 NKWMMKASMNTKRRGIALASLGGPIYAIGGL-DDNTCFNDVERYDIESDQWSTVAPMNTP 449
Query: 419 VGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLG 478
G + V +Y GG D M + + ++ Y + W +++ + L
Sbjct: 450 RGGVGSVALV--NHVYAVGGNDGMAS-LSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLH 506
Query: 479 ERIVIVGGY-----TRRILAYDPQSNKFVKCADMKDRRMHHG-ATVMGNKLYVTGGRRLT 532
+ +VGG+ + YDP+SNK+ A + R G ATVMG K++ GG
Sbjct: 507 GCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMG-KIFAVGGHNGN 565
Query: 533 TDCNIEDSASFDCYDPETDTWTSQGQLPH 561
N + + +DP + W G + H
Sbjct: 566 AYLN-----TVEAFDPVLNRWELVGSVSH 589
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 185 bits (469), Expect = 1e-46
Identities = 145/553 (26%), Positives = 246/553 (44%), Gaps = 34/553 (6%)
Query: 21 LRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGI 80
LR++ + + + L DV + AG IP HR VL++ S YF AMF + E + +V+++G+
Sbjct: 169 LRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGV 228
Query: 81 DPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMI 140
DP L+ +V Y YTG + D + ++ AA +LQ ++ + CS++L QL PSNCLG+
Sbjct: 229 DPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIR 288
Query: 141 RLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYL-GDDGLCGEEEKVFEA 199
+ C L A + + F EV + + L A E+ L DD +EE +F A
Sbjct: 289 SFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHA 348
Query: 200 LMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQM 259
LM W+ HD+Q R+ + L +RL + P A L++S LE K M
Sbjct: 349 LMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLL-------ADLETSSMFTGDLECQKLLM 401
Query: 260 FSLCGTTVPDCKLLLHVP---PRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLA 316
++ +P+ + ++ P PR S L +GG D+ + T + Y +T W +
Sbjct: 402 EAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGG-MDAMKGTTTIEKYDLRTNSWLHIG 460
Query: 317 KLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSH 376
+ R + + +YV+GG G + + V F+ W + PM R+
Sbjct: 461 TMNGRRLQFGVAVIDNKLYVVGG---RDGLKTL-NTVECFNPVGKIWTVMPPMSTHRHGL 516
Query: 377 RSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLF 436
+ ++++GG +G + ++ER+D W +ASM V + +LY
Sbjct: 517 GVATLEGPMYAVGG-HDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAI 575
Query: 437 GGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY--------- 487
GG D + ++ ++ + N W + + +VGG+
Sbjct: 576 GGRD-GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCS 634
Query: 488 --TRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDC 545
+ + YDP+ + + A + R +G+KLYV GG T N +S
Sbjct: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVES----- 689
Query: 546 YDPETDTWTSQGQ 558
YD + + W Q
Sbjct: 690 YDAQRNEWKESMQ 702
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 185 bits (469), Expect = 1e-46
Identities = 144/551 (26%), Positives = 246/551 (44%), Gaps = 34/551 (6%)
Query: 21 LRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGI 80
LR++ + + + L DV + AG IP HR VL++ S YF AMF + E + +V+++G+
Sbjct: 169 LRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGV 228
Query: 81 DPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMI 140
DP L+ +V Y YTG + D + ++ AA +LQ ++ + CS++L QL PSNCLG+
Sbjct: 229 DPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIR 288
Query: 141 RLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYL-GDDGLCGEEEKVFEA 199
+ C L A + + F EV + + L A E+ L DD +EE +F A
Sbjct: 289 SFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHA 348
Query: 200 LMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPACQIILETAKRQM 259
LM W+ HD+Q R+ + L +RL + P A L++S LE K M
Sbjct: 349 LMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLL-------ADLETSSMFTGDLECQKLLM 401
Query: 260 FSLCGTTVPDCKLLLHVP---PRNSYQDFLILLGGRKDSQQTTRDVLLYSKQTGQWQSLA 316
++ +P+ + ++ P PR S L +GG D+ + T + Y +T W +
Sbjct: 402 EAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGG-MDAMKGTTTIEKYDLRTNSWLHIG 460
Query: 317 KLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSH 376
+ R + + +YV+GG G + + V F+ W + PM R+
Sbjct: 461 TMNGRRLQFGVAVIDNKLYVVGG---RDGLKTL-NTVECFNPVGKIWTVMPPMSTHRHGL 516
Query: 377 RSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVAVKDQRLYLF 436
+ ++++GG +G + ++ER+D W +ASM V + +LY
Sbjct: 517 GVATLEGPMYAVGG-HDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAI 575
Query: 437 GGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGY--------- 487
GG D + ++ ++ + N W + + +VGG+
Sbjct: 576 GGRD-GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCS 634
Query: 488 --TRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDC 545
+ + YDP+ + + A + R +G+KLYV GG T N +S
Sbjct: 635 RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVES----- 689
Query: 546 YDPETDTWTSQ 556
YD + + W +
Sbjct: 690 YDAQRNEWKEE 700
Score = 41.6 bits (96), Expect = 0.002
Identities = 34/145 (23%), Positives = 61/145 (42%), Gaps = 4/145 (2%)
Query: 286 LILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGG--MAVS 343
L +GGR D + + + T +W A + R T + +YV+GG S
Sbjct: 572 LYAIGGR-DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPAS 630
Query: 344 SGRSLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMER 403
+ S +S V + K + W P+ V R + + ++ +GG +G + ++E
Sbjct: 631 NHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY-DGHTYLNTVES 689
Query: 404 YDSICNVWESMASMPVGVLHPAVAV 428
YD+ N W+ + +G V V
Sbjct: 690 YDAQRNEWKEEVPVNIGRAGACVVV 714
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 184 bits (466), Expect = 3e-46
Identities = 131/493 (26%), Positives = 226/493 (45%), Gaps = 19/493 (3%)
Query: 69 EKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSSYLQ 128
E +V++K +D TL ++ YVYT E + +NV ++ AA +LQ + + C +L+
Sbjct: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
Query: 129 SQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRDYLGDDG 188
SQL P NCLG+ +++ +C L KA A F +V S + L ++ + D
Sbjct: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
Query: 189 L-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDALLQSSPA 247
L EEKVFEA++ W+ HD R+ +M L + VRL + + + +AL+++S A
Sbjct: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
Query: 248 CQIILETAKRQMFSLCGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDSQQTTRDVLLYSK 307
C+ L A + + + + + ++++GG+ + + R V Y
Sbjct: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ--APKAIRSVECYDF 240
Query: 308 QTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYIFSLKLNQWRLGE 367
+ +W +A+LP+R +A + + ++ +GG SL V + +QW
Sbjct: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF----NGSLRVRTVDSYDPVKDQWTSVA 296
Query: 368 PMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMASMPVGVLHPAVA 427
M R + + ++++GG +G + S+E Y+ N W +A M V
Sbjct: 297 NMRDRRSTLGAAVLNGLLYAVGGF-DGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG 355
Query: 428 VKDQRLYLFGGED-IMQNPVRLIQVYHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGG 486
V LY GG D + + ++ Y+ + N W + + A VL + VGG
Sbjct: 356 VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG 415
Query: 487 Y-----TRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSA 541
+ + + YDP +N + + ADM R + G + LYV GG CN+ A
Sbjct: 416 HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL---A 470
Query: 542 SFDCYDPETDTWT 554
S + Y+P TD WT
Sbjct: 471 SVEYYNPTTDKWT 483
Score = 36.6 bits (83), Expect = 0.065
Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 9/83 (10%)
Query: 477 LGERIVIVGGYT----RRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLT 532
L + +V+VGG R + YD + ++ + A++ RR G M ++ GG +
Sbjct: 217 LPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 276
Query: 533 TDCNIEDSASFDCYDPETDTWTS 555
DS YDP D WTS
Sbjct: 277 LRVRTVDS-----YDPVKDQWTS 294
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 182 bits (461), Expect = 1e-45
Identities = 146/568 (25%), Positives = 246/568 (43%), Gaps = 38/568 (6%)
Query: 3 EESLDGLLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAM 62
EE D + F + S + +R+ L DV++ G + HR VLA+S PYF AM
Sbjct: 7 EELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAM 66
Query: 63 FCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEA 122
F + E + ++ ++G+DP L+ ++++ Y G I NV ++ AS LQ + +A
Sbjct: 67 FTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDA 126
Query: 123 CSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELRD 182
C ++L+ +L P NCLG+ + +E + C L A F EV+ S +E AL L D
Sbjct: 127 CCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMS---EEFLALPLED 183
Query: 183 YL----GDDGLCGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIAN 238
L D+ EE+VFEA + W+++D + R Y+ EL +RL P F +
Sbjct: 184 VLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQ 243
Query: 239 DALLQSSPACQIILETAKRQMFSLCGTTVPDCKLLLHVP-----PR--NSYQDFLILLGG 291
D L++ C+ +++ AK + L P H+P PR S + +GG
Sbjct: 244 DDLVRCCHKCRDLVDEAKD--YHLMPERRP------HLPAFRTRPRCCTSIAGLIYAVGG 295
Query: 292 RKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSH 351
+ + V ++ W+ + T + ++ +Y +GG G+ +S
Sbjct: 296 LNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY---DGQLRLS- 351
Query: 352 NVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVW 411
V ++ + + W M R + + I+ GG +G + S+E Y + W
Sbjct: 352 TVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGY-DGNSSLSSVETYSPETDKW 410
Query: 412 ESMASMPVGVLHPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKMETRMIKNVC 471
+ SM V V + R+Y+ GG D +Q ++ Y+ +W + K
Sbjct: 411 TVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQ-IFSSVEHYNHHTATWHPAAGMLNKRCR 469
Query: 472 APAVVLGERIVIVGGYTRR-----ILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVT 526
A LG ++ + GGY Y ++++ M RR +LY
Sbjct: 470 HGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAV 529
Query: 527 GGRRLTTDCNIEDSASFDCYDPETDTWT 554
GG + +S + YDPETD WT
Sbjct: 530 GGYD-----GQSNLSSVEMYDPETDCWT 552
Score = 47.4 bits (111), Expect = 4e-05
Identities = 36/131 (27%), Positives = 56/131 (42%), Gaps = 5/131 (3%)
Query: 287 ILLGGRKDSQQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGR 346
I + G D Q V Y+ T W A + + + A +L ++V GG S
Sbjct: 432 IYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFL 491
Query: 347 SLVSHNVYIFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDS 406
S+ ++S +QW L PM R A ++++GG +GQ + S+E YD
Sbjct: 492 SIAE----MYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGY-DGQSNLSSVEMYDP 546
Query: 407 ICNVWESMASM 417
+ W MA M
Sbjct: 547 ETDCWTFMAPM 557
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/73 (34%), Positives = 34/73 (46%), Gaps = 13/73 (17%)
Query: 494 YDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGR----RLTTDCNIEDSASFDCYDPE 549
+DP +N + +C M R G V+ LY GG RL+T + Y+PE
Sbjct: 309 FDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLST---------VEAYNPE 359
Query: 550 TDTWTSQGQLPHK 562
TDTWT G + K
Sbjct: 360 TDTWTRVGSMNSK 372
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,648,780
Number of Sequences: 37866
Number of extensions: 920156
Number of successful extensions: 3024
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 1721
Number of HSP's gapped (non-prelim): 368
length of query: 581
length of database: 18,247,518
effective HSP length: 108
effective length of query: 473
effective length of database: 14,157,990
effective search space: 6696729270
effective search space used: 6696729270
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.