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Search of human proteins with 10181096
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
(1168 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 2336 0.0
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 2196 0.0
gi|34486092 adenylate cyclase 5 [Homo sapiens] 1513 0.0
gi|4557257 adenylate cyclase 8 [Homo sapiens] 749 0.0
gi|31083193 adenylate cyclase 1 [Homo sapiens] 728 0.0
gi|115387102 adenylate cyclase 2 [Homo sapiens] 684 0.0
gi|24497587 adenylate cyclase 4 [Homo sapiens] 649 0.0
gi|4557255 adenylate cyclase 7 [Homo sapiens] 639 0.0
gi|148536830 adenylate cyclase 3 [Homo sapiens] 624 e-178
gi|50959205 adenylate cyclase 9 [Homo sapiens] 216 8e-56
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 119 2e-26
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 119 2e-26
gi|134152694 guanylate cyclase 2F [Homo sapiens] 118 3e-26
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 117 8e-26
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 114 4e-25
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 109 2e-23
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 109 2e-23
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 109 2e-23
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 109 2e-23
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 109 2e-23
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 108 4e-23
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 105 3e-22
gi|222080083 guanylate cyclase 2C [Homo sapiens] 100 8e-21
gi|239754370 PREDICTED: hypothetical protein [Homo sapiens] 35 0.42
gi|239748924 PREDICTED: hypothetical protein [Homo sapiens] 35 0.42
gi|239742946 PREDICTED: hypothetical protein [Homo sapiens] 35 0.42
gi|28466969 prostaglandin D2 receptor [Homo sapiens] 35 0.55
gi|209976994 adenylate cyclase 10 [Homo sapiens] 33 2.1
gi|25777647 small conductance calcium-activated potassium channe... 33 2.1
gi|25777645 small conductance calcium-activated potassium channe... 33 2.1
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 2336 bits (6054), Expect = 0.0
Identities = 1168/1168 (100%), Positives = 1168/1168 (100%)
Query: 1 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP 60
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
Sbjct: 1 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP 60
Query: 61 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR 120
PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
Sbjct: 61 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR 120
Query: 121 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY 180
RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
Sbjct: 121 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY 180
Query: 181 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
Sbjct: 181 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240
Query: 241 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300
CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
Sbjct: 241 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300
Query: 301 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360
VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
Sbjct: 301 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360
Query: 361 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
Sbjct: 361 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420
Query: 421 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480
LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
Sbjct: 421 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480
Query: 481 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540
HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
Sbjct: 481 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540
Query: 541 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR 600
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
Sbjct: 541 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR 600
Query: 601 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK 660
QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
Sbjct: 601 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK 660
Query: 661 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC 720
YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
Sbjct: 661 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC 720
Query: 721 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT 780
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT
Sbjct: 721 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT 780
Query: 781 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA 840
PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA
Sbjct: 781 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA 840
Query: 841 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV 900
MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
Sbjct: 841 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV 900
Query: 901 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF 960
ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
Sbjct: 901 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF 960
Query: 961 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS 1020
LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
Sbjct: 961 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS 1020
Query: 1021 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN 1080
EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
Sbjct: 1021 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN 1080
Query: 1081 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG 1140
FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
Sbjct: 1081 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG 1140
Query: 1141 YQLECRGVVKVKGKGEMTTYFLNGGPSS 1168
YQLECRGVVKVKGKGEMTTYFLNGGPSS
Sbjct: 1141 YQLECRGVVKVKGKGEMTTYFLNGGPSS 1168
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 2196 bits (5691), Expect = 0.0
Identities = 1114/1168 (95%), Positives = 1115/1168 (95%), Gaps = 53/1168 (4%)
Query: 1 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP 60
MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP
Sbjct: 1 MSWFSGLLVPKVDERKTAWGERNGQKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGP 60
Query: 61 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR 120
PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR
Sbjct: 61 PRCPWQDDAFIRRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWR 120
Query: 121 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY 180
RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY
Sbjct: 121 RLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAY 180
Query: 181 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240
VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW
Sbjct: 181 VALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLW 240
Query: 241 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300
CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN
Sbjct: 241 CPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTN 300
Query: 301 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360
VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT
Sbjct: 301 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 360
Query: 361 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420
KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC
Sbjct: 361 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHC 420
Query: 421 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480
LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV
Sbjct: 421 LRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRV 480
Query: 481 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540
HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA
Sbjct: 481 HCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNA 540
Query: 541 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR 600
YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR
Sbjct: 541 YLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFR 600
Query: 601 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK 660
QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK
Sbjct: 601 QMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKK 660
Query: 661 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC 720
YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC
Sbjct: 661 YSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSC 720
Query: 721 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLT 780
GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANM+
Sbjct: 721 GSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMY------------------ 762
Query: 781 PADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA 840
FIGNMLLSLLASSVFLHISSIGKLA
Sbjct: 763 -----------------------------------FIGNMLLSLLASSVFLHISSIGKLA 787
Query: 841 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV 900
MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV
Sbjct: 788 MIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPV 847
Query: 901 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF 960
ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF
Sbjct: 848 ILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHF 907
Query: 961 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS 1020
LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS
Sbjct: 908 LARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS 967
Query: 1021 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN 1080
EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN
Sbjct: 968 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNN 1027
Query: 1081 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG 1140
FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG
Sbjct: 1028 FQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG 1087
Query: 1141 YQLECRGVVKVKGKGEMTTYFLNGGPSS 1168
YQLECRGVVKVKGKGEMTTYFLNGGPSS
Sbjct: 1088 YQLECRGVVKVKGKGEMTTYFLNGGPSS 1115
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 1513 bits (3916), Expect = 0.0
Identities = 791/1165 (67%), Positives = 908/1165 (77%), Gaps = 20/1165 (1%)
Query: 16 KTAWGERNGQ-----KRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAF 70
K+AW ER G R +RRG +GG + + + G P +
Sbjct: 100 KSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVG 159
Query: 71 I--RRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQS 128
+ RRG EL AV G + ++A + P AV G +C L+Q+F+S
Sbjct: 160 LEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLG-ACCLALLQIFRS 218
Query: 129 KQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAA 188
K+F S KLERLYQRYFF++NQSSLT+LMAVLVL+ V+LAFHAA Q Y+A+LA A
Sbjct: 219 KKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAV 278
Query: 189 ALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYI 248
+ + + V+CNR +F QD M + Y ++ ++ AVQV G L PRS S G+W VFF+Y
Sbjct: 279 GVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYT 338
Query: 249 AYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHY 308
YTLLP+RMRAAVLSG+ LS LHL +A + N D FL KQL +NVL+F CTN++G+CTHY
Sbjct: 339 IYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHY 398
Query: 309 PAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFH 368
PAEVSQRQAFQETR IQARLH Q EN+QQERLLLSVLP+HVAMEMK DIN K+EDMMFH
Sbjct: 399 PAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFH 458
Query: 369 KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD 428
KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD
Sbjct: 459 KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD 518
Query: 429 CYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 488
CYYCVSGLPEARADHAHCCVEMG+DMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR
Sbjct: 519 CYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 578
Query: 489 KWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIE 548
KWQFDVWSNDVTLANHMEAGG+AGRIHIT+ATL YLNGDYEVEPG GGERNAYLKE IE
Sbjct: 579 KWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIE 638
Query: 549 TFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAF----SRTKDSKAFRQMGI 604
TFLIL +QKRKEEKAM+AK+ R R NS+ P W +R F + SK ++MG
Sbjct: 639 TFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGF 698
Query: 605 DDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRK 664
+D N Q++ NPEDEVDEFL RAIDARSID+LR +HVR+FLLTF+ DLEKKYS++
Sbjct: 699 EDPKDKN--AQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQ 756
Query: 665 VDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLF 724
VD RFGAYVACA LVF FICF+Q+ I PHS ML Y + LLL + V + +YSC LF
Sbjct: 757 VDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLF 816
Query: 725 PKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADI 784
P LQ LSR IVRS+ +ST VG+F++ LVF +A NMFTCN + C A+ N++ + +
Sbjct: 817 PSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQV 876
Query: 785 TACHLQQ--LNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMI 842
ACH+ + +NYSLG + C P C+FPEYF ++LLSLLA SVFL IS IGKL ++
Sbjct: 877 NACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLM 936
Query: 843 FVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA-AGRVALKYMTPVI 901
+ LIY VL++ P T+FDN DLL+ + + N CP A +VALK +TP+I
Sbjct: 937 LAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTS--QCPEHATKVALKVVTPII 993
Query: 902 LLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFL 961
+ VF LALYLHAQQVESTARLDFLWKLQAT EKEEMEELQAYNRRLLHNILPKDVAAHFL
Sbjct: 994 ISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL 1053
Query: 962 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 1021
ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE
Sbjct: 1054 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 1113
Query: 1022 ERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNF 1081
+RFRQLEKIKTIGSTYMAASGLN STYD+VG++HI ALAD+AM+LM+QMK+INEHSFNNF
Sbjct: 1114 DRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNF 1173
Query: 1082 QMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGY 1141
QMKIGLN+GPVVAGVIGARKPQYDIWGNTVNV+SRMDSTGVPDRIQVTTD+YQVLAA Y
Sbjct: 1174 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTY 1233
Query: 1142 QLECRGVVKVKGKGEMTTYFLNGGP 1166
QLECRGVVKVKGKGEM TYFLNGGP
Sbjct: 1234 QLECRGVVKVKGKGEMMTYFLNGGP 1258
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 749 bits (1935), Expect = 0.0
Identities = 445/1078 (41%), Positives = 636/1078 (58%), Gaps = 76/1078 (7%)
Query: 114 SGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFH--- 170
+G +R ++ F+S LERLYQRYF + S ++ + VL LL H
Sbjct: 144 NGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSL 203
Query: 171 -AAPARPQPAYVALLACAAALFVGLMVVCNR----HSFRQDSMWVVSYVVLGILAAVQVG 225
+AP P + + + +VV + H++ Q S V + + A +G
Sbjct: 204 ASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLG 263
Query: 226 GALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFL 285
L D G+ +F ++ Y++LP+ + A+L+GLG S L +IL + R
Sbjct: 264 YGLLGD------GIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVIS 317
Query: 286 WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSV 345
Q+ A +LF+C N GI Y ++ +QRQAF ETR ++ARL L+ EN++QERL+LSV
Sbjct: 318 INQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSV 377
Query: 346 LPQHVAMEMKEDINTKKEDMM---FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVM 402
LP+ V +EM D+ +++ + FH+IYI +++NVSILFAD++GFT+L++ +AQELV
Sbjct: 378 LPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVR 437
Query: 403 TLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVR 462
LNELFARFD+LA E+HCLRIKILGDCYYCVSGLPE R DHAHCCVEMG+ MI+ I VR
Sbjct: 438 MLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVR 497
Query: 463 EVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQ 522
T +V+MR+GIHSG V CGVLGLRKWQFDVWS DV +AN +E+GG GRIHI++ATL
Sbjct: 498 SRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLD 557
Query: 523 YLNGDYEVEPGRGGERNAYLKEQHIETFLI-------LGASQKRKEEKAMLAKLQRTRAN 575
LNGDY VE G G ERN +L++ +IET+LI L + +E + + + A
Sbjct: 558 CLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGAT 617
Query: 576 SMEGLMPRWVP-DRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDA 634
EG +P D + A + I+ + +E+++ + ID
Sbjct: 618 FTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDL 677
Query: 635 RSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHS 694
RS D+LR++H++ F L F+ LE KYS+ D F + + CA +V FI IQ L+
Sbjct: 678 RSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSR 737
Query: 695 TLMLGIYASIFLLL---LITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVL 751
+ + I SI ++L L+ + Y C P L++ I + + S+L
Sbjct: 738 VMPMTIQFSILIMLHSALVLITTAEDYKC---LPLILRKTCCWINETYLARNVIIFASIL 794
Query: 752 LVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCS 811
+ F AI N+ C+ +S + L + + CS
Sbjct: 795 INFLGAILNILWCDFD--KSIPLKNLTFNSSAVFT---------------------DICS 831
Query: 812 FPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGV 871
+PEYF+ +L+++ +VFL ++S+ KLA++ ++ IY LL A +F YD
Sbjct: 832 YPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIY-ALLTETVYAGLFLRYD----- 885
Query: 872 HGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQAT 931
L S E F G K ++ +++ +F LA++ H QQ+E TARLDFLW++QA
Sbjct: 886 -NLNHSGEDFLG----------TKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAK 934
Query: 932 GEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF 991
E EM+EL+ +N +L NILP VA HFL ++R N+ELY QS + V VMFASI F++F
Sbjct: 935 EEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADF 994
Query: 992 YVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQV 1051
Y + E NN+GVECLRLLNEIIADFDE++ E+RF+ +EKIKTIGSTYMA SGL+
Sbjct: 995 YSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCE 1054
Query: 1052 GR-SHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNT 1110
+ H+ ALAD+++ L E ++ IN+HSFNNF+++IG++ G VVAGVIGA+KPQYDIWG T
Sbjct: 1055 DKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKT 1114
Query: 1111 VNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKG----KGEMTTYFLNG 1164
VN++SRMDSTGV RIQV + Y +L +G+ + RG + VKG +G++ TYFL G
Sbjct: 1115 VNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLG 1172
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 728 bits (1880), Expect = 0.0
Identities = 449/1103 (40%), Positives = 629/1103 (57%), Gaps = 96/1103 (8%)
Query: 101 GGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLV 160
GG P R+ + RR ++ ++F +LE L++ Y ++ Q++ +AVL
Sbjct: 11 GGGGAGEPGGAERAAGTSRRRGLRACD-EEFACPELEALFRGYTLRLEQAATLKALAVLS 69
Query: 161 LLTAVL-LAFHAAPARPQPAYV-ALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLG- 217
LL L LA P P LF+ L+VV N S + + V + L
Sbjct: 70 LLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLF 129
Query: 218 ------ILAAVQVGG------ALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGL 265
+ +GG A P + G+W + +++Y LLP+R A+ GL
Sbjct: 130 SLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGL 189
Query: 266 GLSTLHLILAWQLNRGDA-FLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGY 324
++ HL++ L LW+ LGAN LLF+ N+ G+ E SQR+AF + R
Sbjct: 190 VVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSC 249
Query: 325 IQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFAD 384
I+ RL L+ EN +QERLL+S+LP++VAMEMKED K + +FHKIYIQ+HDNVSILFAD
Sbjct: 250 IEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF-LKPPERIFHKIYIQRHDNVSILFAD 308
Query: 385 IEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHA 444
I GFT LASQCTAQELV LNELF +FD+LA ENHC RIKILGDCYYCVSGL + + DHA
Sbjct: 309 IVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHA 368
Query: 445 HCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANH 504
HCCVEMG+DMI+ I+ V E T V++NMRVG+H+GRV CGVLGLRKWQ+DVWSNDVTLAN
Sbjct: 369 HCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANV 428
Query: 505 MEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKA 564
MEA G G++HIT+ TL LNGDYEVEPG G ERN++LK +IETF I+ + +++
Sbjct: 429 MEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGL 488
Query: 565 MLAKLQRTRANSMEG-------------LMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDN 611
+L+ ++ + + + +P +D R + N
Sbjct: 489 ILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRN 548
Query: 612 RGTQDA----LNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDP 667
R + P V+ ++SR ++AR + L + F L ++ + E+KY + D
Sbjct: 549 RSSFSTNVVYTTPGTRVNRYISRLLEARQTE-LEMADLNFFTLKYKHVEREQKYHQLQDE 607
Query: 668 RFGAYVACALLVFCFICFIQLLIFPHS--TLMLGIYASIFLLLLITVLICAVYSCGSLFP 725
F + V L++ + LLIFP S L+L ++ FL+ + L C FP
Sbjct: 608 YFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQC---FP 664
Query: 726 KALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADIT 785
L R T + IF V+L+++ A + C L +
Sbjct: 665 GCLTIQIR---------TVLCIFIVVLIYSVA------------QGCVVGCLPWAWSSKP 703
Query: 786 ACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVL 845
L L+ S G L T+P C + + L+ L ++F +SS+ K+ ++ L
Sbjct: 704 NSSLVVLS-SGGQRTAL--PTLP-CESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGL 759
Query: 846 GLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVI-LLV 904
Y+++L L G G V+ + P++ +L+
Sbjct: 760 TTSYILVLEL--------------------------SGYTRTGGGAVSGRSYEPIVAILL 793
Query: 905 FALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARE 964
F+ AL LHA+QV+ RLD+LW QA E+E+ME+++ NRR+L N+LP VA HFL
Sbjct: 794 FSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSN 853
Query: 965 RRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERF 1024
RN +LYYQS V VMFASI NF++FY+EL+ NN GVECLRLLNEIIADFDE++ ++ +
Sbjct: 854 PRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFY 913
Query: 1025 RQLEKIKTIGSTYMAASGLNASTYDQVGR---SHITALADYAMRLMEQMKHINEHSFNNF 1081
+ +EKIKTIGSTYMAA GL ++ + + SH++ LAD+A+ + + + IN S+N+F
Sbjct: 914 KDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDF 973
Query: 1082 QMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGY 1141
+++G+N+GPVVAGVIGAR+PQYDIWGNTVNV+SRMDSTGV RIQVT +++++L Y
Sbjct: 974 VLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPY 1033
Query: 1142 QLECRGVVKVKGKGEMTTYFLNG 1164
CRG V VKGKGEM TYFL G
Sbjct: 1034 HFVCRGKVSVKGKGEMLTYFLEG 1056
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 684 bits (1766), Expect = 0.0
Identities = 415/1074 (38%), Positives = 624/1074 (58%), Gaps = 78/1074 (7%)
Query: 139 LYQRYFFQMNQSSLTLLMAVLVL--LTAVLLAFHAAPARPQP--AYVALLACAAALFVGL 194
LY+ Y+ Q L + + ++V+ A+L F A + A++ + A A+F +
Sbjct: 33 LYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAI 92
Query: 195 MVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLP 254
++ S + + + S V+ L A+ SP + +F +++ YT+LP
Sbjct: 93 FILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLP 152
Query: 255 IRMRAAVLSGLGLSTLH-LILAWQLNR---GDAFLWKQLGANVLLFLCTNVIGICTHYPA 310
MR A+++ + S+ H ++L+ L+ G L Q+ ANV++F+C N+ G +
Sbjct: 153 FNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLM 212
Query: 311 EVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK----KEDMM 366
E++ +Q +Q+T I++R+ L+ E RQQERLLLS+LP H+AMEMK +I + K M
Sbjct: 213 ELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQM 272
Query: 367 -----FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 421
FH +Y+++H NVSIL+ADI GFT LAS C+ ELV LNELF +FD++A EN C+
Sbjct: 273 ENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECM 332
Query: 422 RIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVH 481
RIKILGDCYYCVSGLP + +HA CV+MG+DM EAI VR+ TGV++NMRVG+HSG V
Sbjct: 333 RIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVL 392
Query: 482 CGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAY 541
CGV+GL+KWQ+DVWS+DVTLANHMEAGG GR+HI+ TL++LNG Y+VE G G R+ Y
Sbjct: 393 CGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPY 452
Query: 542 LKEQHIETFLILGASQKRKEEKAMLAKLQ-----RTRAN-SMEGLMPRWVPDRAFSRT-- 593
LK+ ++T+ ++ +R+ + + + RA+ M + W + F+
Sbjct: 453 LKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHH 512
Query: 594 KDSKAFRQMGIDDS----------SKDNRGTQDALNPEDEVDEFLSRAIDARSIDQ--LR 641
+DS I + ++ R E+E++E + +AID + + L+
Sbjct: 513 RDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLK 572
Query: 642 KDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIY 701
+ ++R L F + LEK+Y P F YV CA L+F I +Q+L+ P ++++ +
Sbjct: 573 SEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISF 632
Query: 702 ASIFLLLLITVLIC---AVYSCGSLFPKALQRLSRS--IVRSRA-HSTAVGIFSVLLVFT 755
+ FLLL + +C + C L L +S I+ +R ++ I + ++
Sbjct: 633 GAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILM 692
Query: 756 SAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEY 815
A+ NMF + + N T +A + Q + F Y
Sbjct: 693 MAVFNMFFLSDS--EETIPPTANTTNTSFSASNNQ-----------VAILRAQNLFFLPY 739
Query: 816 FIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLA 875
FI + +L L++ SVFL ++ K+ +I ++ L+ +LL A + +Y +L
Sbjct: 740 FIYSCILGLISCSVFLRVNYELKM-LIMMVALVGYNTILLHTHAHVLGDYSQVL------ 792
Query: 876 SSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKE 935
+ P + LK M V L +F + L + +Q E RLDFLWK + E+E
Sbjct: 793 --------FERPGIWK-DLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKERE 843
Query: 936 EMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVEL 995
E+E ++ NR LL N+LP VA HFLAR +N+ELY+QS +CV VMFASI +F EFY E
Sbjct: 844 EIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTES 903
Query: 996 EANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS- 1054
+ N EG+ECLRLLNEIIADFD+++S+ +F +EKIKTIGSTYMAA+GL+A + +
Sbjct: 904 DVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEP 963
Query: 1055 -----HITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1109
HI + ++A L+ ++ IN+HSFN+F++++G+N GPV+AGVIGA+KPQYDIWGN
Sbjct: 964 ERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGN 1023
Query: 1110 TVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1163
TVNV+SRMDSTGV D+IQVT + VL GY CRG++ VKGKG++ TYF+N
Sbjct: 1024 TVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVN 1077
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 649 bits (1675), Expect = 0.0
Identities = 428/1093 (39%), Positives = 597/1093 (54%), Gaps = 115/1093 (10%)
Query: 140 YQRYFFQMNQSSLTLLMAVLVLLT-AVLLAFHAAPARP---QPAYVALLACAAALFVGLM 195
Y+ Y+ Q L LL+ +VL A LLA A R P+++ + CA F L+
Sbjct: 17 YETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLL 76
Query: 196 VVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPV----FFVYIAYT 251
+ +R Q W L +A + +G A SA W V F ++ AY
Sbjct: 77 GLASREQRLQ--RWTRPLSGLVWVALLALGHAFLFTGGVVSA--WDQVSYFLFVIFTAYA 132
Query: 252 LLPIRMRAAVLSGLGLSTLHLI-----LAWQLNRGDAFLWKQLGANVLLFLCTNVIGICT 306
+LP+ MR A ++GL S HL+ L Q + A L QL AN +LFLC NV G+
Sbjct: 133 MLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALL-PQLAANAVLFLCGNVAGVYH 191
Query: 307 HYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK----- 361
E + R F+E + +R L E + QE LLLS+LP ++A EMK +I +
Sbjct: 192 KALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQ 251
Query: 362 ----KEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE 417
+ FH +Y+++H VS+L+ADI GFT LAS+C+ +ELV+ LNELF +FD++A E
Sbjct: 252 GSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKE 311
Query: 418 NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHS 477
+ C+RIKILGDCYYCVSGLP + DHA CV MG+DM AI +R TGV++NMRVG+HS
Sbjct: 312 HECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHS 371
Query: 478 GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGE 537
G V CGV+GL+KWQ+DVWS+DVTLANHMEAGG GR+HIT ATL L G Y VE
Sbjct: 372 GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEH 431
Query: 538 RNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPR-----------WVP 586
R+ YL+E T+L++ + ++EK L +S+EGL R W
Sbjct: 432 RDPYLRELGEPTYLVIDPRAEEEDEKGTAGGL----LSSLEGLKMRPSLLMTRYLESWGA 487
Query: 587 DRAFSR---------------TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRA 631
+ F+ K +F D S+ RG D L+ D +
Sbjct: 488 AKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQ 547
Query: 632 IDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIF 691
++++ + KD L F+ +++EK+Y P F Y AC LVF IQ+L+
Sbjct: 548 LNSQKQWKQSKD-FNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVT 606
Query: 692 PHSTLMLGIYASIFLLLLITVLIC---AVYSCGSLFPKALQ---RLSRSIVRSRAHSTAV 745
+ Y+ FLL L+ + +C + C PK L LS + A+
Sbjct: 607 NRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIAL 666
Query: 746 GIFSVLLVFTSAIANMF---TCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPL 802
G ++LLVF AI ++F T + P + A ++ + +L + P
Sbjct: 667 GTATILLVFAMAITSLFFFPTSSDCPFQ---------------APNVSSMISNLSWELP- 710
Query: 803 CEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIF 862
G++P S P Y + L L+ S+FLH+S F L L+ L+LL L ++F
Sbjct: 711 --GSLPLISVP-YSMHCCTLGFLSCSLFLHMS--------FELKLL-LLLLWLAASCSLF 758
Query: 863 DNYDLLLGVHGLASSNET------FDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQV 916
+H A +E LD K M + +F L + A+Q
Sbjct: 759 --------LHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQN 810
Query: 917 ESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCE 976
E RLDFLWK + E+EE E ++ R LL N+LP VA F+ + RRN++LY+QS E
Sbjct: 811 EYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYE 870
Query: 977 CVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGST 1036
CV V+FAS+ +F EFY E N+EG+ECLRLLNEIIADFDE++S+ +F +EKIKTIGST
Sbjct: 871 CVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGST 930
Query: 1037 YMAASGLNASTYDQVGR------SHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMG 1090
YMAA+GLNA++ + SH+ + ++A+ L ++ IN+HSFNNF++++GLN G
Sbjct: 931 YMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHG 990
Query: 1091 PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK 1150
PVVAGVIGA+KPQYDIWGNTVNV+SRM+STGV +IQVT + L + GY RGV+K
Sbjct: 991 PVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIK 1050
Query: 1151 VKGKGEMTTYFLN 1163
VKGKG++ TYFLN
Sbjct: 1051 VKGKGQLCTYFLN 1063
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 639 bits (1648), Expect = 0.0
Identities = 411/1079 (38%), Positives = 592/1079 (54%), Gaps = 83/1079 (7%)
Query: 137 ERLYQRYFFQMNQSSLTL---LMAVLVLLTAVLLAFHAAPARPQPAYVALLACAAALFVG 193
+ LY++Y L L L+A + +++AF A + + A+F
Sbjct: 19 DALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAA 78
Query: 194 LMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPV----FFVYIA 249
L V+ + W+ + +L V +G L D + +A W V F V++
Sbjct: 79 LSVLMYVECLLR--RWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFLFIVFVV 136
Query: 250 YTLLPIRMRAAVLSGLGLSTLHLILAWQLNRG----DAFLWKQLGANVLLFLCTNVIGIC 305
YTLLP MR AV G + HL++ L G + QL AN ++FLC N+ G
Sbjct: 137 YTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAF 196
Query: 306 THYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKE-- 363
+ + + R F T IQ R L+ E RQQE LLLSVLP H++M MK I + +
Sbjct: 197 HKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEH 256
Query: 364 -------DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAA 416
D FH +Y+++H NVSIL+ADI GFT LAS C+ +ELV+ LNELF +FD++A
Sbjct: 257 GDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAK 316
Query: 417 ENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIH 476
N C+RIKILGDCYYCVSGLP + HA CV+MG+DM +AI VRE TGV++NMRVGIH
Sbjct: 317 ANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIH 376
Query: 477 SGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGG 536
SG V CGV+GLRKWQ+DVWS+DV+LAN MEA G GR+HIT ATL++L+ YEVE G G
Sbjct: 377 SGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQ 436
Query: 537 ERNAYLKEQHIETFLILGASQKRKEEKAML-------AKLQRTRANSMEGLMPRWVPDRA 589
+R+ YLKE +I T+L++ ++ + A L+ + M + W R
Sbjct: 437 QRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARP 496
Query: 590 FSRT--KDSKAFRQMGIDDSSKD------NRGTQD-ALNP-----EDEVDEFLSRAIDAR 635
F+ ++S + + + + + +R T D +++P +D D+ + AI+
Sbjct: 497 FAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDEMLSAIEGL 556
Query: 636 SIDQ---LRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFP 692
S + + D F F + E++Y PR ACA L+F I + +L+ P
Sbjct: 557 SSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLLMP 616
Query: 693 HSTLMLGIYASIFLLLLITVL-ICAVYSCGSLFPK--ALQRLSRSIVRSRAHSTAVGIFS 749
T LG+ + +L VL +C P L +S + + + +
Sbjct: 617 R-TAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLRLTLAVLT 675
Query: 750 VLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPT 809
+ + T AI N L L P + + GL A + T
Sbjct: 676 IGSLLTVAIIN----------------LPLMPFQVPEL---PVGNETGLLAASSK-TRAL 715
Query: 810 CSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLL- 868
C Y+ + +L +A SVFL +S K+ ++ V + YLVL L P +D
Sbjct: 716 CEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSP----CWQWDCCG 771
Query: 869 LGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKL 928
G+ L N T G P+ LK MT L++F + L ++Q++ RLD LWK
Sbjct: 772 QGLGNLTKPNGTTSG--TPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKK 829
Query: 929 QATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF 988
+ E EE E ++ NR LL N+LP VAAHF+ ++ N++ Y+QS +CV VMFAS+ +F
Sbjct: 830 KFKKEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKLNEDWYHQSYDCVCVMFASVPDF 888
Query: 989 SEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN-AST 1047
FY E + N EG+ECLRLLNEIIADFDE++ + +F +EKIKTIGSTYMAA+GL+ AS
Sbjct: 889 KVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASG 948
Query: 1048 YD----QVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQ 1103
++ + +HI + ++++ LM ++ IN HSFN+F++++G+N GPV+AGVIGARKPQ
Sbjct: 949 HENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQ 1008
Query: 1104 YDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFL 1162
YDIWGNTVNV+SRM+STG +IQVT + +L GY ECRG++ VKGKGE+ TYF+
Sbjct: 1009 YDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFV 1067
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 624 bits (1608), Expect = e-178
Identities = 399/1105 (36%), Positives = 609/1105 (55%), Gaps = 101/1105 (9%)
Query: 126 FQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAP-ARPQPAYVALL 184
F F LE LYQ YF + +L +L+ L ++ A + + A +A+
Sbjct: 52 FMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVA 111
Query: 185 ACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALA---ADPRSPSAGLWC 241
L + L V+C + V VL +L Q+ L A + S +
Sbjct: 112 GIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGW 171
Query: 242 PVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAW-------QLNRGDAFLWKQLGANVL 294
VFFV+ + LP+ + V+ + +H ++ Q L +++ ANV
Sbjct: 172 QVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVF 231
Query: 295 LFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM 354
L+LC +GI ++Y A+ R+AF E R ++ +++L+ +++QQE L+LS+LP+HVA EM
Sbjct: 232 LYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEM 291
Query: 355 KEDIN---TKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARF 411
+D+ ++K+ F+ +Y+ +H+NVSILFADI GFT L+S C+AQELV LNELFARF
Sbjct: 292 LKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARF 351
Query: 412 DKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNM 471
DKLAA+ H LRIKILGDCYYC+ GLP+ R DHA C + MG+ M+EAIS VRE T V+M
Sbjct: 352 DKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDM 411
Query: 472 RVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVE 531
RVG+H+G V GVLG ++WQ+DVWS DVT+AN MEAGG GR+HI+++T+ L G+++VE
Sbjct: 412 RVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVE 471
Query: 532 PGRGGERNAYLKEQHIETFLILG--------ASQKRKEEKAMLAKLQRTRANSMEGLMPR 583
PG GG R YL+E+ IET+LI+ A+Q A+ + +S L+
Sbjct: 472 PGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIET 531
Query: 584 WVPD---RAFSRTKDSKAFRQMGIDDSSKDNRGTQ-----------DALNPEDEVDEFLS 629
P+ + T + + D+ S N + DA E E+++ L+
Sbjct: 532 KEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLN 591
Query: 630 RAIDARSIDQLRKDHVRRFLLT--FQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQ 687
A+ R Q+ K FLL+ F ++E +YS + + + GA +C+ +V ++
Sbjct: 592 EALLERESAQVVKKR-NTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVE 650
Query: 688 LLIFP-----HSTLMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHS 742
+LI P + T M+G I LL+L + A++ FPK L S I R+R
Sbjct: 651 ILIDPWLMTNYVTFMVG---EILLLILTICSLAAIFP--RAFPKKLVAFSTWIDRTRWAR 705
Query: 743 TAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPL 802
+ ++ ++ + + +M +C P++ TA G++
Sbjct: 706 NTWAMLAIFILVMANVVDMLSC----------LQYYTGPSNATA----------GMET-- 743
Query: 803 CEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLA-MIFVLGLIYLVLLLLGPPATI 861
EG+ P+Y+ +LSL+A+ + + +S + KL M+ V G + + L P +
Sbjct: 744 -EGS--CLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRP--V 798
Query: 862 FDNYD---------LLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLH 912
FD YD ++ + + N +G D V KY V++ + L+ Y
Sbjct: 799 FDEYDHKRFREHDLPMVALEQMQGFNPGLNGTD--RLPLVPSKYSMTVMVFLMMLSFYYF 856
Query: 913 AQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 972
++ VE AR FLWK++ +KE + E++ +N L+ N+LP+ VA HFL ++R++ELY
Sbjct: 857 SRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYS 916
Query: 973 QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT 1032
Q+ + + VMFAS+ NF++FY E NN G+ECLR LNEII+DFD ++ +FR + KIKT
Sbjct: 917 QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKT 976
Query: 1033 IGSTYMAASGL----------NASTYDQVGR---SHITALADYAMRLMEQMKHINEHSFN 1079
IGSTYMAASG+ +++ D+ R H+ LAD+A+ + + + +IN SFN
Sbjct: 977 IGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFN 1036
Query: 1080 NFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAK 1139
NF ++IG+N G V+AGVIGARKP YDIWGNTVNV+SRM+STGV IQV + +L
Sbjct: 1037 NFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREY 1096
Query: 1140 GYQLECRGVVKVKGKGEMTTYFLNG 1164
G++ RG + VKGKGE+ T+FL G
Sbjct: 1097 GFRFVRRGPIFVKGKGELLTFFLKG 1121
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 216 bits (551), Expect = 8e-56
Identities = 130/357 (36%), Positives = 201/357 (56%), Gaps = 36/357 (10%)
Query: 246 VYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQL-------NRGDAFLWKQLGANVLLFLC 298
+++ YT++ + + ++ G+ S L + + G L +L + LL C
Sbjct: 231 LFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGC 290
Query: 299 TNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEM---- 354
+ IG+ ++V R F + I L+ E +ER++ SV+P+ +A ++
Sbjct: 291 IHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQG 350
Query: 355 -------------------KEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQC 395
K+ + +K + F +Q+ + VSILFADI GFT +++
Sbjct: 351 DEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANK 410
Query: 396 TAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMI 455
+A LV LN+LF RFD+L E C +I LGDCYYCV+G PE RADHA+CC+EMG+ MI
Sbjct: 411 SAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMI 470
Query: 456 EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIH 515
+AI + VNMRVG+H+G V CG+LG+R+++FDVWSNDV LAN ME G AG++H
Sbjct: 471 KAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVH 530
Query: 516 ITRATLQYLNGDYEVEPGRGGER--NAYLKEQ--HIETFLILGASQKRKEEKAMLAK 568
I+ AT +YL+ YE+E G+ ER + + +Q ++T+LI G Q+ KE + A+
Sbjct: 531 ISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISG--QRAKESRCSCAE 585
Score = 196 bits (499), Expect = 8e-50
Identities = 167/554 (30%), Positives = 265/554 (47%), Gaps = 67/554 (12%)
Query: 632 IDARSIDQLRKDH-----VRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFI 686
+D D L KD+ + +F L F ++LE+ Y + F F
Sbjct: 729 VDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEE--VIKNSPVKTFASPTFS 786
Query: 687 QLL-IFPHSTLMLGIYASIFLLLLITVL-----ICAVYSCGSLFPKALQRLSRSIVRSRA 740
LL +F +T+ L + + FL + AV+S L L+ LS ++
Sbjct: 787 SLLDVFLSTTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALL----LEVLSLAV----- 837
Query: 741 HSTAVGIFSVLLVFTSAIANMFTCNHTPI--------RSCAARMLNLTPADITACHLQQL 792
S+ +VF + ++ C + R C +L PA H+
Sbjct: 838 --------SIRMVFF--LEDVMACTKRLLEWIAGWLPRHCIGAILVSLPALAVYSHVTS- 886
Query: 793 NYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVL 852
Y + P+ G+ + Y L S + SS LA + G + L+
Sbjct: 887 EYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSS----------LATVVGAGPLLLLY 936
Query: 853 LLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALAL--Y 910
+ L P +++ + L V +S + R A V+L+ F L L +
Sbjct: 937 VSLCPDSSVLTSP--LDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVW 994
Query: 911 LHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDEL 970
++ E + RL + ++A + +++ ++ LL NI+P + +A + + +
Sbjct: 995 FLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIP-----YHVAEQLKVSQT 1049
Query: 971 YYQSCECVAVMFASIANFSEFYVELEANNEG-VECLRLLNEIIADFDEIISEERFRQLEK 1029
Y ++ + V+FASI NFSEFY E N EG EC R+LNE+I DFDE++S+ + +EK
Sbjct: 1050 YSKNHDSGGVIFASIVNFSEFY---EENYEGGKECYRVLNELIGDFDELLSKPDYSSIEK 1106
Query: 1030 IKTIGSTYMAASGLNASTYDQVG--RSHITALADYAMRLMEQMKHINEHS-FNNFQMKIG 1086
IKTIG+TYMAASGLN + + H+ L ++A +M + N + + NF++++G
Sbjct: 1107 IKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVG 1166
Query: 1087 LNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECR 1146
N GP+ AGVIG K YDIWG+TVN++SRMD+TGV RIQV+ + Y+VL+ GY + R
Sbjct: 1167 FNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYR 1226
Query: 1147 GVVKVKGKGEMTTY 1160
G V VKGKG+M TY
Sbjct: 1227 GTVNVKGKGQMKTY 1240
Score = 84.3 bits (207), Expect = 6e-16
Identities = 81/372 (21%), Positives = 162/372 (43%), Gaps = 56/372 (15%)
Query: 833 ISSIGKLAM-IFVLGLIYLVLLL-LGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAG 890
+S +G +M I VL L+Y V+ L L + Y +L G +E P AG
Sbjct: 218 LSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEAC--FPSPGAG 275
Query: 891 RVALKYMTPVIL--LVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLL 948
+ + ++ +L + A+ ++L + +R FL Q+ +++E +A R++
Sbjct: 276 ALHWELLSRGLLHGCIHAIGVHLFVMS-QVRSRSTFLKVGQSIMHGKDLEVEKALKERMI 334
Query: 949 HNILPKDVAAHFLARERRNDE-----------------------------LYYQSCECVA 979
H+++P+ +A + + E Q E V+
Sbjct: 335 HSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVS 394
Query: 980 VMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMA 1039
++FA I F++ + AN + LLN++ FD + E + EKI T+G Y
Sbjct: 395 ILFADIVGFTK----MSANKSAHALVGLLNDLFGRFDRLCEETK---CEKISTLGDCYYC 447
Query: 1040 ASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGA 1099
+G D H + + +++ ++ + M++G++ G V+ G++G
Sbjct: 448 VAGCPEPRAD-----HAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGM 502
Query: 1100 RKPQYDIWGNTVNVSSRMDSTGVPDRIQVT-------TDLYQVLAAKGYQLECRGVVKVK 1152
R+ ++D+W N VN+++ M+ GV ++ ++ D Y++ K + + VV +
Sbjct: 503 RRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQ 562
Query: 1153 GKGEMTTYFLNG 1164
KG + TY ++G
Sbjct: 563 LKG-LKTYLISG 573
Score = 82.0 bits (201), Expect = 3e-15
Identities = 104/433 (24%), Positives = 174/433 (40%), Gaps = 80/433 (18%)
Query: 159 LVLLTAVLLAFHAAPARPQPAYVALLACAAALFV-GLMVVCNRHSFRQDSM--------W 209
L L T L + AA P PA +A+ + A L V L V F +D M W
Sbjct: 799 LTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEW 858
Query: 210 VVSYVVLGILAAVQVG-GALAADPRSPS---AGLWCPVF---------FVYIAYTLLPIR 256
+ ++ + A+ V ALA S + PVF Y + L
Sbjct: 859 IAGWLPRHCIGAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSW 918
Query: 257 MRAAVLSGLGLSTLHL----------ILAWQLNRGDAFLWKQLGAN-------------- 292
MR+++ + +G L L +L L+ F ++ N
Sbjct: 919 MRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLI 978
Query: 293 ----VLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLH---LQHENRQQERLLLSV 345
VL+F ++ + EVS R + G ++A LH +Q Q + LL ++
Sbjct: 979 GQEVVLVFFLLLLLVWFLNREFEVSYRLHYH---GDVEADLHRTKIQSMRDQADWLLRNI 1035
Query: 346 LPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCT--AQELVMT 403
+P HVA ++K + Y + HD+ ++FA I F+ + +E
Sbjct: 1036 IPYHVAEQLKVS-----------QTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRV 1084
Query: 404 LNELFARFDKLAAE---NHCLRIKILGDCYYCVSGLPEARA-------DHAHCCVEMGVD 453
LNEL FD+L ++ + +IK +G Y SGL A+A +H E +
Sbjct: 1085 LNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKE 1144
Query: 454 MIEAIS-LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAG 512
M+ + + N +RVG + G + GV+G K +D+W + V +A+ M+ G
Sbjct: 1145 MMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1204
Query: 513 RIHITRATLQYLN 525
RI ++ + + L+
Sbjct: 1205 RIQVSEESYRVLS 1217
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 119 bits (298), Expect = 2e-26
Identities = 83/237 (35%), Positives = 127/237 (53%), Gaps = 25/237 (10%)
Query: 935 EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE 994
EE+E + RLL +LP VA E + Q V + F+ I F+
Sbjct: 840 EELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDIVGFTT---- 891
Query: 995 LEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS 1054
+ A +E +E + LLN++ FD II + K++TIG YM ASGL G+
Sbjct: 892 ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPQRN----GQR 944
Query: 1055 HITALADYAMRLME-----QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1109
H +A+ ++ ++ +M+H+ E +++IGL+ GP VAGV+G P+Y ++G+
Sbjct: 945 HAAEIANMSLDILSAVGTFRMRHMPEVPV---RIRIGLHSGPCVAGVVGLTMPRYCLFGD 1001
Query: 1110 TVNVSSRMDSTGVPDRIQVTTDLYQVLAA--KGYQLECRGVVKVKGKGEMTTYFLNG 1164
TVN +SRM+STG+P RI V +L A GYQ+E RG ++KGKG T++L G
Sbjct: 1002 TVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058
Score = 101 bits (251), Expect = 5e-21
Identities = 67/225 (29%), Positives = 116/225 (51%), Gaps = 23/225 (10%)
Query: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
L+ E ++ +RLL +LP VA +K + E + V++ F+DI GFT+
Sbjct: 842 LELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYF----------EQVTLYFSDIVGFTT 891
Query: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVE 449
+++ E+V LN+L+ FD + + +++ +GD Y SGLP+ HA
Sbjct: 892 ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIAN 951
Query: 450 MGVDMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 507
M +D++ A+ +R + V V +R+G+HSG GV+GL ++ ++ + V A+ ME+
Sbjct: 952 MSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMES 1011
Query: 508 GGRAGRIHITRAT---LQYLNGDYEVE-------PGRGGERNAYL 542
G RIH+ +T L+ L+ Y+VE G+G E +L
Sbjct: 1012 TGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWL 1056
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 119 bits (297), Expect = 2e-26
Identities = 81/241 (33%), Positives = 128/241 (53%), Gaps = 24/241 (9%)
Query: 933 EKEEMEELQAYNRR------LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA 986
EK E QAY LL+ ILP VA +R + + ++ + V + F+ I
Sbjct: 813 EKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIV 868
Query: 987 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNAS 1046
F+ L A + ++ + LLN++ FD II + K++TIG YM SGL
Sbjct: 869 GFTA----LSAESTPMQVVTLLNDLYTCFDAIIDNF---DVYKVETIGDAYMVVSGLPGR 921
Query: 1047 TYDQVGRSHITALADYAMRLMEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1104
G+ H +A A+ L++ + I + +++IG++ GPV AGV+G + P+Y
Sbjct: 922 N----GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRY 977
Query: 1105 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG-YQLECRGVVKVKGKGEMTTYFLN 1163
++G+TVN +SRM+S G +I V++ L G +QLE RG V++KGKG+M TY+L
Sbjct: 978 CLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLL 1037
Query: 1164 G 1164
G
Sbjct: 1038 G 1038
Score = 106 bits (264), Expect = 1e-22
Identities = 70/237 (29%), Positives = 124/237 (52%), Gaps = 31/237 (13%)
Query: 319 QETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNV 378
+ T+ Y++ E R+ E LL +LP VA ++K + E D+V
Sbjct: 818 ERTQAYLE-------EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSV 860
Query: 379 SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 438
+I F+DI GFT+L+++ T ++V LN+L+ FD + +++ +GD Y VSGLP
Sbjct: 861 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPG 920
Query: 439 ARAD-HAHCCVEMGVDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW 495
HA M + +++A+S +R + +R+G+H+G V GV+GL+ ++ ++
Sbjct: 921 RNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLF 980
Query: 496 SNDVTLANHMEAGGRAGRIHITRATLQYLN----------GDYEVEPGRGGERNAYL 542
+ V A+ ME+ G+A +IH++ T L+ GD E++ G+G R +L
Sbjct: 981 GDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMK-GKGKMRTYWL 1036
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 118 bits (296), Expect = 3e-26
Identities = 79/237 (33%), Positives = 131/237 (55%), Gaps = 25/237 (10%)
Query: 935 EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE 994
EE+E + +LL +LP VA ++ + + + V + F+ I F+
Sbjct: 844 EELEIEKQKTEKLLTQMLPPSVAESL----KKGCTVEPEGFDLVTLYFSDIVGFTT---- 895
Query: 995 LEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRS 1054
+ A +E +E + LLN++ FD II + K++TIG YM ASGL G
Sbjct: 896 ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPKRN----GSR 948
Query: 1055 HITALADYAMRLME-----QMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGN 1109
H +A+ ++ ++ +M+H+ E +++IGL+ GPVVAGV+G P+Y ++G+
Sbjct: 949 HAAEIANMSLDILSSVGTFKMRHMPEVPV---RIRIGLHSGPVVAGVVGLTMPRYCLFGD 1005
Query: 1110 TVNVSSRMDSTGVPDRIQVTTDLYQVL--AAKGYQLECRGVVKVKGKGEMTTYFLNG 1164
TVN +SRM+STG+P RI V+ +L ++GY++E RG ++KGKG T++L G
Sbjct: 1006 TVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIG 1062
Score = 107 bits (266), Expect = 9e-23
Identities = 70/225 (31%), Positives = 119/225 (52%), Gaps = 23/225 (10%)
Query: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
L+ E ++ E+LL +LP VA +K+ + E D V++ F+DI GFT+
Sbjct: 846 LEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF----------DLVTLYFSDIVGFTT 895
Query: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVE 449
+++ E+V LN+L+ FD + + +++ +GD Y SGLP+ HA
Sbjct: 896 ISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIAN 955
Query: 450 MGVDMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA 507
M +D++ ++ +R + V V +R+G+HSG V GV+GL ++ ++ + V A+ ME+
Sbjct: 956 MSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMES 1015
Query: 508 GGRAGRIHITRAT---LQYLNGDYEVE-------PGRGGERNAYL 542
G RIH++ +T LQ L+ YEVE G+G E +L
Sbjct: 1016 TGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWL 1060
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 117 bits (292), Expect = 8e-26
Identities = 73/221 (33%), Positives = 124/221 (56%), Gaps = 18/221 (8%)
Query: 947 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 1006
LL+ ILP VA +R + + ++ + V + F+ I F+ L A + ++ +
Sbjct: 848 LLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIVGFTA----LSAESTPMQVVT 899
Query: 1007 LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRL 1066
LLN++ FD +I + K++TIG YM SGL GR H +A A+ L
Sbjct: 900 LLNDLYTCFDAVIDNF---DVYKVETIGDAYMVVSGLPVRN----GRLHACEVARMALAL 952
Query: 1067 MEQMK--HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPD 1124
++ ++ I +++IG++ GPV AGV+G + P+Y ++G+TVN +SRM+S G
Sbjct: 953 LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEAL 1012
Query: 1125 RIQVTTDLYQVLAA-KGYQLECRGVVKVKGKGEMTTYFLNG 1164
+I ++++ VL G++LE RG V++KGKG++ TY+L G
Sbjct: 1013 KIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
Score = 105 bits (263), Expect = 2e-22
Identities = 73/238 (30%), Positives = 125/238 (52%), Gaps = 33/238 (13%)
Query: 319 QETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNV 378
+ T+ Y++ E R+ E LL +LP VA ++K + E D+V
Sbjct: 833 ERTQAYLE-------EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSV 875
Query: 379 SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 438
+I F+DI GFT+L+++ T ++V LN+L+ FD + +++ +GD Y VSGLP
Sbjct: 876 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLP- 934
Query: 439 ARADHAHCC--VEMGVDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDV 494
R H C M + +++A+ +R + +R+GIH+G V GV+GL+ ++ +
Sbjct: 935 VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCL 994
Query: 495 WSNDVTLANHMEAGGRAGRIHI---TRATLQ-------YLNGDYEVEPGRGGERNAYL 542
+ + V A+ ME+ G A +IH+ T+A L+ L GD E++ G+G R +L
Sbjct: 995 FGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMK-GKGKVRTYWL 1051
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 114 bits (286), Expect = 4e-25
Identities = 64/194 (32%), Positives = 106/194 (54%), Gaps = 10/194 (5%)
Query: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
L+ E ++ LL S+ P VA ++ + ++ +K D+V++LF+DI GFT+
Sbjct: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQG----------QQVQARKFDDVTMLFSDIVGFTA 532
Query: 391 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM 450
+ +QCT +++ LNEL+ RFD +++ +GD Y +GL HA M
Sbjct: 533 ICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALM 592
Query: 451 GVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGR 510
+ M+E V G + MR+GIHSG V GV+G+R ++ ++ N+VTLA+ E+G
Sbjct: 593 ALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSH 652
Query: 511 AGRIHITRATLQYL 524
RI+++ T Q L
Sbjct: 653 PRRINVSPTTYQLL 666
Score = 92.4 bits (228), Expect = 2e-18
Identities = 62/212 (29%), Positives = 110/212 (51%), Gaps = 18/212 (8%)
Query: 927 KLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFAS 984
KL+AT E+ + +EE + LL++I P DVA + ++ + + V ++F+
Sbjct: 471 KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTMLFSD 526
Query: 985 IANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN 1044
I F+ + ++ + +LNE+ FD F + K++TIG Y A+GL+
Sbjct: 527 IVGFTAICAQCTP----MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVAAGLH 579
Query: 1045 ASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQY 1104
+ H +A A+++ME + + QM+IG++ G V+AGV+G R P+Y
Sbjct: 580 RKSL-----CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRY 634
Query: 1105 DIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136
++GN V ++S+ +S P RI V+ YQ+L
Sbjct: 635 CLFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 109 bits (272), Expect = 2e-23
Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 252
Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 253 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 312
Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 313 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 372
Query: 506 EAGGRAGRIHITRATLQYL 524
E+ +I+++ T + L
Sbjct: 373 ESCSVPRKINVSPTTYRLL 391
Score = 80.5 bits (197), Expect = 9e-15
Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 925 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 982
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 194 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 249
Query: 983 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 1042
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 250 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 302
Query: 1043 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1102
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 303 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 357
Query: 1103 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136
+Y ++GN V ++++ +S VP +I V+ Y++L
Sbjct: 358 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 391
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 109 bits (272), Expect = 2e-23
Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487
Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 506 EAGGRAGRIHITRATLQYL 524
E+ +I+++ T + L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626
Score = 80.5 bits (197), Expect = 9e-15
Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 925 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 982
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 983 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 1042
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1043 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1102
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 538 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1103 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136
+Y ++GN V ++++ +S VP +I V+ Y++L
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 109 bits (272), Expect = 2e-23
Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487
Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 506 EAGGRAGRIHITRATLQYL 524
E+ +I+++ T + L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626
Score = 80.5 bits (197), Expect = 9e-15
Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 925 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 982
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 983 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 1042
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1043 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1102
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 538 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1103 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136
+Y ++GN V ++++ +S VP +I V+ Y++L
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 109 bits (272), Expect = 2e-23
Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487
Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 506 EAGGRAGRIHITRATLQYL 524
E+ +I+++ T + L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626
Score = 80.5 bits (197), Expect = 9e-15
Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 925 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 982
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 983 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 1042
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1043 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1102
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 538 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1103 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136
+Y ++GN V ++++ +S VP +I V+ Y++L
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 109 bits (272), Expect = 2e-23
Identities = 62/199 (31%), Positives = 106/199 (53%), Gaps = 10/199 (5%)
Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487
Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 506 EAGGRAGRIHITRATLQYL 524
E+ +I+++ T + L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626
Score = 80.5 bits (197), Expect = 9e-15
Identities = 58/214 (27%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 925 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 982
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 983 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 1042
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1043 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1102
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 538 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1103 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136
+Y ++GN V ++++ +S VP +I V+ Y++L
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 108 bits (269), Expect = 4e-23
Identities = 61/195 (31%), Positives = 104/195 (53%), Gaps = 10/195 (5%)
Query: 326 QARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADI 385
QA L+ E ++ LL S+ P VA ++ + + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQLWQG----------QVVQAKKFSNVTMLFSDI 487
Query: 386 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 445
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 446 CCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 505
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 506 EAGGRAGRIHITRAT 520
E+ +I+++ T
Sbjct: 608 ESCSVPRKINVSPTT 622
Score = 78.6 bits (192), Expect = 3e-14
Identities = 57/212 (26%), Positives = 105/212 (49%), Gaps = 18/212 (8%)
Query: 925 LWKLQATGEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 982
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 983 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASG 1042
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1043 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKP 1102
L+ + +H +A A+++ME + +M+IGL+ G V AGV+G + P
Sbjct: 538 LHKES-----DTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1103 QYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQ 1134
+Y ++GN V ++++ +S VP +I V+ Y+
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYR 624
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 105 bits (261), Expect = 3e-22
Identities = 67/209 (32%), Positives = 109/209 (52%), Gaps = 18/209 (8%)
Query: 331 LQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTS 390
L+ E ++ + LL SVLP VA E++ + +++DNV+ILF+ I GF +
Sbjct: 383 LEDEKKKTDTLLYSVLPPSVANELRHK----------RPVPAKRYDNVTILFSGIVGFNA 432
Query: 391 LASQCT----AQELVMTLNELFARFDKLAAENH---CLRIKILGDCYYCVSGLPEARADH 443
S+ A ++V LN+L+ RFD L +++ +GD Y VSGLPE H
Sbjct: 433 FCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHH 492
Query: 444 AHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLAN 503
A + +DM+E V +V G +V + +GIH+G V GV+G R ++ ++ N V L +
Sbjct: 493 ARSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTS 551
Query: 504 HMEAGGRAGRIHITRATLQYLNGDYEVEP 532
E G G+I+++ T + L +P
Sbjct: 552 RTETTGEKGKINVSEYTYRCLMSPENSDP 580
Score = 100 bits (248), Expect = 1e-20
Identities = 74/257 (28%), Positives = 129/257 (50%), Gaps = 19/257 (7%)
Query: 914 QQVESTARLDFLW-KLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 972
++ + T L+ L +LQ T +E+ + LL+++LP VA R +
Sbjct: 361 EEYKLTQELEILTDRLQLT--LRALEDEKKKTDTLLYSVLPPSVANEL----RHKRPVPA 414
Query: 973 QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKT 1032
+ + V ++F+ I F+ F + + ++ + LLN++ FD + + + K++T
Sbjct: 415 KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVET 474
Query: 1033 IGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPV 1092
+G YM SGL H ++ A+ +ME + + Q+ IG++ G V
Sbjct: 475 VGDKYMTVSGLPEPCIH-----HARSICHLALDMMEIAGQVQVDG-ESVQITIGIHTGEV 528
Query: 1093 VAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAA-----KGYQLECRG 1147
V GVIG R P+Y ++GNTVN++SR ++TG +I V+ Y+ L + + LE RG
Sbjct: 529 VTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRG 588
Query: 1148 VVKVKGKGE-MTTYFLN 1163
V +KGK E M +FL+
Sbjct: 589 PVSMKGKKEPMQVWFLS 605
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 100 bits (249), Expect = 8e-21
Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 19/223 (8%)
Query: 946 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1005
RL +LP+ V + ELY E V + F+ I F+ + +E +
Sbjct: 795 RLNFMLLPRLVVKSLKEKGFVEPELY----EEVTIYFSDIVGFTTIC----KYSTPMEVV 846
Query: 1006 RLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMR 1065
+LN+I FD I+ + K++TIG YM ASGL G H +A A+
Sbjct: 847 DMLNDIYKSFDHIVDHH---DVYKVETIGDAYMVASGLPKRN----GNRHAIDIAKMALE 899
Query: 1066 LMEQMKHINEHSFNNFQM--KIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1123
++ M + +IG++ GP AGV+G + P+Y ++G+TVN +SRM+STG+P
Sbjct: 900 ILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLP 959
Query: 1124 DRIQVTTDLYQVLAAKGYQL--ECRGVVKVKGKGEMTTYFLNG 1164
RI V+ +L Q E RG +KG+G TTY+L G
Sbjct: 960 LRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002
Score = 94.7 bits (234), Expect = 4e-19
Identities = 75/293 (25%), Positives = 138/293 (47%), Gaps = 34/293 (11%)
Query: 334 ENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 393
E + +RL +LP+ V +KE + E ++ V+I F+DI GFT++
Sbjct: 789 ERDRADRLNFMLLPRLVVKSLKEKGFVEPE----------LYEEVTIYFSDIVGFTTICK 838
Query: 394 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGV 452
T E+V LN+++ FD + + +++ +GD Y SGLP+ + HA +M +
Sbjct: 839 YSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMAL 898
Query: 453 DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGR 510
+++ + + + G+ + +R+G+HSG GV+G++ ++ ++ + V A+ ME+ G
Sbjct: 899 EILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL 958
Query: 511 AGRIHITRATLQYLNGD-----YEVE-----PGRGGERNAYLKEQHIETF------LILG 554
RIH++ +T+ L YEV GRG E +L + F +
Sbjct: 959 PLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVEN 1018
Query: 555 ASQKRKEEKAMLA-KLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDD 606
+ + E M+A LQ+ +A + PR R S K + + Q+ D
Sbjct: 1019 QQRLQAEFSDMIANSLQKRQAAGIRSQKPR----RVASYKKGTLEYLQLNTTD 1067
>gi|239754370 PREDICTED: hypothetical protein [Homo sapiens]
Length = 435
Score = 35.0 bits (79), Expect = 0.42
Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 14/101 (13%)
Query: 25 QKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIR--------RGGP 76
++R R G +AGG + R P S PA CP D+F R + P
Sbjct: 63 KRRRERAGRKAGGDFRDLSLPLARSLPPESRRPARRANCP---DSFRRVLVNHLAQKRSP 119
Query: 77 GKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRS 117
+ +AV L + EV T +GG A PD + R+
Sbjct: 120 TPAR---YKAVRLAEREREVRTPSGGAAPCVPDEPAPAART 157
>gi|239748924 PREDICTED: hypothetical protein [Homo sapiens]
Length = 435
Score = 35.0 bits (79), Expect = 0.42
Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 14/101 (13%)
Query: 25 QKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIR--------RGGP 76
++R R G +AGG + R P S PA CP D+F R + P
Sbjct: 63 KRRRERAGRKAGGDFRDLSLPLARSLPPESRRPARRANCP---DSFRRVLVNHLAQKRSP 119
Query: 77 GKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRS 117
+ +AV L + EV T +GG A PD + R+
Sbjct: 120 TPAR---YKAVRLAEREREVRTPSGGAAPCVPDEPAPAART 157
>gi|239742946 PREDICTED: hypothetical protein [Homo sapiens]
Length = 435
Score = 35.0 bits (79), Expect = 0.42
Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 14/101 (13%)
Query: 25 QKRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAFIR--------RGGP 76
++R R G +AGG + R P S PA CP D+F R + P
Sbjct: 63 KRRRERAGRKAGGDFRDLSLPLARSLPPESRRPARRANCP---DSFRRVLVNHLAQKRSP 119
Query: 77 GKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRS 117
+ +AV L + EV T +GG A PD + R+
Sbjct: 120 TPAR---YKAVRLAEREREVRTPSGGAAPCVPDEPAPAART 157
>gi|28466969 prostaglandin D2 receptor [Homo sapiens]
Length = 359
Score = 34.7 bits (78), Expect = 0.55
Identities = 32/111 (28%), Positives = 50/111 (45%), Gaps = 25/111 (22%)
Query: 661 YSRKVDPRFGAYVACAL----LVFCFI----------------CFIQLLIFPHSTLMLG- 699
Y R + R GA VA + L FC + CFIQ++ S +LG
Sbjct: 140 YRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGY 199
Query: 700 --IYASIFLLLLITVLICAVYSCGSLFP--KALQRLSRSIVRSRAHSTAVG 746
+Y+S+ LL++ ++C + + +L+ + LQR RS R A A G
Sbjct: 200 SVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADG 250
>gi|209976994 adenylate cyclase 10 [Homo sapiens]
Length = 1610
Score = 32.7 bits (73), Expect = 2.1
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 6/81 (7%)
Query: 427 GDCYYCVSGLP-EARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVL 485
G + CV G P E D +E +D+ + S V ++ V++ G+ SG V CG++
Sbjct: 341 GCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVSI----GVASGIVFCGIV 396
Query: 486 G-LRKWQFDVWSNDVTLANHM 505
G + ++ V V LA M
Sbjct: 397 GHTVRHEYTVIGQKVNLAARM 417
>gi|25777647 small conductance calcium-activated potassium channel
protein 2 isoform b [Homo sapiens]
Length = 231
Score = 32.7 bits (73), Expect = 2.1
Identities = 30/137 (21%), Positives = 49/137 (35%), Gaps = 7/137 (5%)
Query: 287 KQLGANVL-----LFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERL 341
K ANVL ++ T ++ H QR+ Q ++ + N Q L
Sbjct: 72 KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTL 131
Query: 342 LLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELV 401
+ Q++ +M D+N + ED F K + + L I L SQ Q+
Sbjct: 132 VDLAKTQNIMYDMISDLNERSED--FEKRIVTLETKLETLIGSIHALPGLISQTIRQQQR 189
Query: 402 MTLNELFARFDKLAAEN 418
+ +DK N
Sbjct: 190 DFIEAQMESYDKHVTYN 206
>gi|25777645 small conductance calcium-activated potassium channel
protein 2 isoform a [Homo sapiens]
Length = 579
Score = 32.7 bits (73), Expect = 2.1
Identities = 30/137 (21%), Positives = 49/137 (35%), Gaps = 7/137 (5%)
Query: 287 KQLGANVL-----LFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERL 341
K ANVL ++ T ++ H QR+ Q ++ + N Q L
Sbjct: 420 KNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTL 479
Query: 342 LLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELV 401
+ Q++ +M D+N + ED F K + + L I L SQ Q+
Sbjct: 480 VDLAKTQNIMYDMISDLNERSED--FEKRIVTLETKLETLIGSIHALPGLISQTIRQQQR 537
Query: 402 MTLNELFARFDKLAAEN 418
+ +DK N
Sbjct: 538 DFIEAQMESYDKHVTYN 554
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,606,961
Number of Sequences: 37866
Number of extensions: 1901103
Number of successful extensions: 8185
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 7987
Number of HSP's gapped (non-prelim): 92
length of query: 1168
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1055
effective length of database: 13,968,660
effective search space: 14736936300
effective search space used: 14736936300
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.