Search of human proteins with 15451844

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
         (918 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...  1956   0.0  
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   754   0.0  
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   728   0.0  
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   684   0.0  
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   648   0.0  
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   516   e-146
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   516   e-146
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   512   e-145
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   509   e-144
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   508   e-143
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   508   e-143
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   497   e-140
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...   488   e-137
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   437   e-122
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   382   e-106
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot...   370   e-102
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   368   e-101
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   368   e-101
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...   368   e-101
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   366   e-101
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   366   e-101
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   361   1e-99
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   361   2e-99
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   361   2e-99
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   361   2e-99
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   361   2e-99
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s...   358   1e-98
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...   353   4e-97
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   353   5e-97
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...   339   6e-93

>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score = 1956 bits (5068), Expect = 0.0
 Identities = 918/918 (100%), Positives = 918/918 (100%)

Query: 1   MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREK 60
           MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREK
Sbjct: 1   MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREK 60

Query: 61  HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120
           HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR
Sbjct: 61  HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120

Query: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSK 180
           ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSK
Sbjct: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSK 180

Query: 181 PTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEI 240
           PTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEI
Sbjct: 181 PTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEI 240

Query: 241 ANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQL 300
           ANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQL
Sbjct: 241 ANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQL 300

Query: 301 ITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC 360
           ITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC
Sbjct: 301 ITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC 360

Query: 361 CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCG 420
           CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCG
Sbjct: 361 CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCG 420

Query: 421 NGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQ 480
           NGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQ
Sbjct: 421 NGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQ 480

Query: 481 CDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLC 540
           CDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLC
Sbjct: 481 CDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLC 540

Query: 541 FEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNG 600
           FEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNG
Sbjct: 541 FEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNG 600

Query: 601 RQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNG 660
           RQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNG
Sbjct: 601 RQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNG 660

Query: 661 HGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM 720
           HGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM
Sbjct: 661 HGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM 720

Query: 721 YYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTP 780
           YYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTP
Sbjct: 721 YYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTP 780

Query: 781 EILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPI 840
           EILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPI
Sbjct: 781 EILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPI 840

Query: 841 PPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAP 900
           PPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAP
Sbjct: 841 PPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAP 900

Query: 901 KFPEYRSQRAGGMISSKI 918
           KFPEYRSQRAGGMISSKI
Sbjct: 901 KFPEYRSQRAGGMISSKI 918


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  754 bits (1947), Expect = 0.0
 Identities = 410/925 (44%), Positives = 539/925 (58%), Gaps = 78/925 (8%)

Query: 8   ARLCLLAFALQPLRPRAAREPG-WTRGSEE-------GSPKLQHELIIPQWKTSESPVRE 59
           AR  LLA A   L P  AR    W +G  +       GS  L        W   +S   +
Sbjct: 11  ARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDL--------WIPVKSFDSK 62

Query: 60  KHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRK---LEDHCFYH 116
            HP    +R+  E +ELI++LE+NE L A S+TETHY   G   +  R    +  HC+YH
Sbjct: 63  NHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYH 122

Query: 117 GTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGF 176
           G VR    S+V+LSTC G+RGLI V  N SYV+EP+  +  ++ ++ ++ LK   G+CG 
Sbjct: 123 GHVRGYSDSAVSLSTCSGLRGLI-VFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGS 181

Query: 177 EHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHK 236
            H+ P      + F   ++   RR KRE L + KYVEL +VAD  EFQ+  +D +  K +
Sbjct: 182 HHNTPNLAAKNV-FPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240

Query: 237 LIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRR-KLLAQKYH 295
           LIEIAN+VDKFYR LNIRI LVG+EVW   + C VS++P+++L  FL WR+ KLL +K H
Sbjct: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300

Query: 296 DNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTH 355
           DNAQL++G+ F GTTIG+AP+M+MC+  QSGG+ MDHS+N +G A T+AHE+GHNFGM H
Sbjct: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360

Query: 356 DSAD---CCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRM 412
           D+ D    C  +   GGCIM A+TG+PFP VF+ C+R++L+  L+ G G+CL N+P+ R 
Sbjct: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420

Query: 413 LYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGT 472
            +GG++CGN ++E+GEECDCGE EEC N CCNA+ CTL+P A CAHG CC  C+L   GT
Sbjct: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480

Query: 473 LCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPG 532
            CR+ +  CDLPEFCTG SPHCP N Y  DG  C+    YCYNG+C T+++QC  LWGPG
Sbjct: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540

Query: 533 ARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARP-LESNAVP 591
           A+PAP +CFE+VN AGD +GNCGK       KC MRDAKCGKIQCQ   +RP + +NAV 
Sbjct: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600

Query: 592 IDTTI-IMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFE 650
           I+T I +  G +I CRGTHVY G     DM DPGLV+ GTKC    IC   QC+N S F 
Sbjct: 601 IETNIPLQQGGRILCRGTHVYLG----DDMPDPGLVLAGTKCADGKICLNRQCQNISVFG 656

Query: 651 TEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVA 710
              C  +C+G GVCNN +NCHC   WAPPFC+  G GGS DSGP+       +  G+LV 
Sbjct: 657 VHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVT 716

Query: 711 ILVLAVLMLMYYCCRQN-------------NKLGQLKPSALPSKLRQQFSCPFRVSQNSG 757
           IL L     + Y  R+               KL  ++PS  P   +    C       + 
Sbjct: 717 ILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQ---PC------QAH 767

Query: 758 TGHANPTFKLQTPQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARN 817
            GH       + P       N   +L+  +    RP    L G + P P      ++ + 
Sbjct: 768 LGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRP----LNGLNVPQP------QSTQR 817

Query: 818 SPGPGSQIERTESSRRPPPSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPR-- 875
              P  +  R  S     P+RP+P  P    +Q   +P PPQK LPA+P+     L    
Sbjct: 818 VLPPLHRAPRAPS----VPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHAL 873

Query: 876 ---PG------GASPLRPPGAGPQQ 891
              PG        +PLRP    P Q
Sbjct: 874 ARTPGQWETGLRLAPLRPAPQYPHQ 898


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  728 bits (1879), Expect = 0.0
 Identities = 358/705 (50%), Positives = 463/705 (65%), Gaps = 31/705 (4%)

Query: 8   ARLCLLAFALQPLRPRAAREPG-WTRGSEE-------GSPKLQHELIIPQWKTSESPVRE 59
           AR  LLA A   L P  AR    W +G  +       GS  L        W   +S   +
Sbjct: 11  ARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDL--------WIPVKSFDSK 62

Query: 60  KHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRK---LEDHCFYH 116
            HP    +R+  E +ELI++LE+NE L A S+TETHY   G   +  R    +  HC+YH
Sbjct: 63  NHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYH 122

Query: 117 GTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGF 176
           G VR    S+V+LSTC G+RGLI V  N SYV+EP+  +  ++ ++ ++ LK   G+CG 
Sbjct: 123 GHVRGYSDSAVSLSTCSGLRGLI-VFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGS 181

Query: 177 EHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHK 236
            H+ P      + F   ++   RR KRE L + KYVEL +VAD  EFQ+  +D +  K +
Sbjct: 182 HHNTPNLAAKNV-FPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240

Query: 237 LIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRR-KLLAQKYH 295
           LIEIAN+VDKFYR LNIRI LVG+EVW   + C VS++P+++L  FL WR+ KLL +K H
Sbjct: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300

Query: 296 DNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTH 355
           DNAQL++G+ F GTTIG+AP+M+MC+  QSGG+ MDHS+N +G A T+AHE+GHNFGM H
Sbjct: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360

Query: 356 DSAD---CCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRM 412
           D+ D    C  +   GGCIM A+TG+PFP VF+ C+R++L+  L+ G G+CL N+P+ R 
Sbjct: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420

Query: 413 LYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGT 472
            +GG++CGN ++E+GEECDCGE EEC N CCNA+ CTL+P A CAHG CC  C+L   GT
Sbjct: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480

Query: 473 LCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPG 532
            CR+ +  CDLPEFCTG SPHCP N Y  DG  C+    YCYNG+C T+++QC  LWGPG
Sbjct: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540

Query: 533 ARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARP-LESNAVP 591
           A+PAP +CFE+VN AGD +GNCGK       KC MRDAKCGKIQCQ   +RP + +NAV 
Sbjct: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600

Query: 592 IDTTI-IMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFE 650
           I+T I +  G +I CRGTHVY G     DM DPGLV+ GTKC    IC   QC+N S F 
Sbjct: 601 IETNIPLQQGGRILCRGTHVYLG----DDMPDPGLVLAGTKCADGKICLNRQCQNISVFG 656

Query: 651 TEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPM 695
              C  +C+G GVCNN +NCHC   WAPPFC+  G GGS DSGP+
Sbjct: 657 VHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPI 701


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  684 bits (1766), Expect = 0.0
 Identities = 336/710 (47%), Positives = 444/710 (62%), Gaps = 18/710 (2%)

Query: 10  LCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQ-WKTSESPVREKHPLKAELR 68
           L LL   L P+ P A    G  +G   G P   H ++  Q W+T         P    + 
Sbjct: 15  LLLLLLLLWPV-PGA----GVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVA 69

Query: 69  VMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVT 128
           + AEG+EL+L+LEKN +L AP Y ETHY   G P        DHC Y G VR    S V 
Sbjct: 70  LEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVV 129

Query: 129 LSTCRGIRGLITVSSNLSYVIEPLPDSKGQ----HLIYRSEHLKPPPGNCGFEHSKPTTR 184
           L TC G+ GLIT+S N SY + P P    +    H I+R E L    G CG  H  P  +
Sbjct: 130 LCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG--HRDPGNK 187

Query: 185 DWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYV 244
                     + R RR  R    + KY+ELY+VAD+  F    R+ + TK +L+E+ANYV
Sbjct: 188 AGMTSLPGGPQSRGRREARR---TRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244

Query: 245 DKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGM 304
           D+  R+L+I++AL GLEVWT  +   V+++  +TLW+FL WRR L AQ+ HD+AQL+TG 
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGR 304

Query: 305 SFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSAS 364
           +F G T+GLAP+  MC    SGGV+ DHSE  IG AATMAHE+GH+ G++HD   CC  +
Sbjct: 305 AFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEA 364

Query: 365 AAD-GGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGY 423
           AA+ GGC+MAAATGHPFP+VF+ C+RR+L  + + GGG CLSN PD  +      CGNG+
Sbjct: 365 AAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGF 424

Query: 424 LEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDL 483
           +E GEECDCG  +EC + CC A NC+LRPGA+CAHG CC +C L   G LCR+    CDL
Sbjct: 425 VEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDL 484

Query: 484 PEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEK 543
           PEFCTG S HCP + Y +DG+PC  G  YC++G C T ++QCQQLWGPG+ PAP+ CF+ 
Sbjct: 485 PEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQV 544

Query: 544 VNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQI 603
           VN AGD  GNCG+D  G    C  RDA CGK+QCQ  +   L  + VP+D+T+ ++G+++
Sbjct: 545 VNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEV 604

Query: 604 QCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGV 663
            CRG      P  + D+L  GLV  GT+CG   +C   +CR  +F E + C   C+ HGV
Sbjct: 605 TCRGALAL--PSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGV 662

Query: 664 CNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILV 713
           CN+N NCHC PGWAPPFC+ PG GGS+DSGP+  E+    +  +L+++L+
Sbjct: 663 CNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLL 712


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  648 bits (1672), Expect = 0.0
 Identities = 327/710 (46%), Positives = 430/710 (60%), Gaps = 44/710 (6%)

Query: 10  LCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQ-WKTSESPVREKHPLKAELR 68
           L LL   L P+ P A    G  +G   G P   H ++  Q W+T         P    + 
Sbjct: 15  LLLLLLLLWPV-PGA----GVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVA 69

Query: 69  VMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVT 128
           + AEG+EL+L+LEKN +L AP Y ETHY   G P        DHC Y G VR    S V 
Sbjct: 70  LEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVV 129

Query: 129 LSTCRGIRGLITVSSNLSYVIEPLPDSKGQ----HLIYRSEHLKPPPGNCGFEHSKPTTR 184
           L TC G+ GLIT+S N SY + P P    +    H I+R E L    G CG  H  P  +
Sbjct: 130 LCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG--HRDPGNK 187

Query: 185 DWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYV 244
                     + R RR  R    + KY+ELY+VAD+  F    R+ + TK +L+E+ANYV
Sbjct: 188 AGMTSLPGGPQSRGRREARR---TRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244

Query: 245 DKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGM 304
           D+  R+L+I++AL GLEVWT  +   V+++  +TLW+FL WRR L AQ+ HD+AQL+TG 
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGR 304

Query: 305 SFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSAS 364
           +F G T+GLAP+  MC    SGGV+ DHSE  IG AATMAHE+GH+ G++HD   CC  +
Sbjct: 305 AFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEA 364

Query: 365 AAD-GGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGY 423
           AA+ GGC+MAAATGHPFP+VF+ C+RR+L  + + GGG CLSN PD  +      CGNG+
Sbjct: 365 AAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGF 424

Query: 424 LEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDL 483
           +E GEECDCG  +EC + CC A NC+LRPGA+CAHG CC +C L   G LCR+    CDL
Sbjct: 425 VEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDL 484

Query: 484 PEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEK 543
           PEFCTG S HCP + Y +DG+PC  G  YC++G C T ++QCQQLWGPG+ PAP+ CF+ 
Sbjct: 485 PEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQV 544

Query: 544 VNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQI 603
           VN AGD  GNCG+D  G    C  RDA CGK+QCQ  +   L  + VP+D+T+ ++G+++
Sbjct: 545 VNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEV 604

Query: 604 QCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGV 663
            CRG      P  + D+L  GLV  GT+CG                             V
Sbjct: 605 TCRGALAL--PSAQLDLLGLGLVEPGTQCG--------------------------PRMV 636

Query: 664 CNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILV 713
           CN+N NCHC PGWAPPFC+ PG GGS+DSGP+  E+    +  +L+++L+
Sbjct: 637 CNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLL 686


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  516 bits (1329), Expect = e-146
 Identities = 313/879 (35%), Positives = 459/879 (52%), Gaps = 88/879 (10%)

Query: 29  GWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAEL------RVMAEGRELILDLEK 82
           G T   +  S K   E + PQ    + P+  K  L+  L      ++  +G   IL+L +
Sbjct: 27  GGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQ 86

Query: 83  NEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVS 142
           N +L     T   Y   G    +     ++C Y G VR    S V++ TC G+RGL+ ++
Sbjct: 87  NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLT 146

Query: 143 SNLSYVIEPLP-DSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR-- 199
              SY +E  P D +G  +I R + L  P   C     +          TQ+  + P   
Sbjct: 147 PERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESV-------HTQKPPEHPLGQ 199

Query: 200 ---RMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIA 256
              R +R+ +   K VEL +VAD+ E QK R D     ++ +E+A  +D F+R LN+R+A
Sbjct: 200 RHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVALLLDTFFRPLNVRVA 258

Query: 257 LVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKYHDNAQLITGMSFHGTTIGLAP 315
           LVGLE WT  ++ E+S NP  TL +FL WRR  LL +  HD+AQL+TG SF G T+G+A 
Sbjct: 259 LVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAI 318

Query: 316 LMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHD---SADCCSASAADGGCIM 372
             ++CS   SGGVNMDHS + +GVA+++AHE+GH+ G+ HD   ++  C   A    CIM
Sbjct: 319 QNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIM 378

Query: 373 AAATGHPFPKVFNGCNRRELDRYLQSGGGMCL-SNMPDTRMLYGGRRCGNGYLEDGEECD 431
            A+T       F+ C+RR L++ L  G G CL   +P    +     CGN ++E GE+CD
Sbjct: 379 EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCD 436

Query: 432 CGEEEECNNPCCNASNCTLRPGAECAH-GSCCHQCKLLAPGTLCREQARQCDLPEFCTGK 490
           CG  ++C +PCC++  C LRPGA+CA  G CC  C+L   G  CR     CDLPEFC G 
Sbjct: 437 CGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGD 496

Query: 491 SPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDT 550
           S  CP +    DG PC GGQA C +G C +Y +QCQ LWGPGA+PA  LC +  N  G+ 
Sbjct: 497 SSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNA 556

Query: 551 FGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPID-TTIIMNGRQIQCRGTH 609
           FG+CG++ +G +  C  RDA CG++QCQ+   +PL  +   +   TI +NG ++ C   H
Sbjct: 557 FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVH 616

Query: 610 VYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQN 669
           +  G     D+  P L + GT CG   +C + +C+       + C  KC+GHGVC++N++
Sbjct: 617 LDLG----SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRH 672

Query: 670 CHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM----YYCCR 725
           C+C  GWAPP C T              ++   +  G+L+++LVL VL+++    +Y  R
Sbjct: 673 CYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRK 785
            + +L QLK            +C +R +Q+  +    P  +    +G ++       L  
Sbjct: 721 LHQRLCQLKGP----------TCQYRAAQSGPSERPGPPQRALLARGTKQA----SALSF 766

Query: 786 PSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPAPN 845
           P+ PP RP         PP P+   L     + P P +         RP P+ P+  +P 
Sbjct: 767 PA-PPSRP--------LPPDPVSKRLQAELADRPNPPT---------RPLPADPVVRSPK 808

Query: 846 CIVSQDFSRPRPPQKALPANPVPGR---RSLPRPGGASP 881
              SQ  ++P PP+K LPA+P  GR     LP PG   P
Sbjct: 809 ---SQGPAKPPPPRKPLPADP-QGRCPSGDLPGPGAGIP 843


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  516 bits (1328), Expect = e-146
 Identities = 313/880 (35%), Positives = 458/880 (52%), Gaps = 91/880 (10%)

Query: 29  GWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAEL------RVMAEGRELILDLEK 82
           G T   +  S K   E + PQ    + P+  K  L+  L      ++  +G   IL+L +
Sbjct: 27  GGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQ 86

Query: 83  NEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVS 142
           N +L     T   Y   G    +     ++C Y G VR    S V++ TC G+RGL+ ++
Sbjct: 87  NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLT 146

Query: 143 SNLSYVIEPLP-DSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR-- 199
              SY +E  P D +G  +I R + L  P   C     +          TQ+  + P   
Sbjct: 147 PERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESV-------HTQKPPEHPLGQ 199

Query: 200 ---RMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIA 256
              R +R+ +   K VEL +VAD+ E QK R D     ++ +E+A  +D F+R LN+R+A
Sbjct: 200 RHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVALLLDTFFRPLNVRVA 258

Query: 257 LVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKYHDNAQLITGMSFHGTTIGLAP 315
           LVGLE WT  ++ E+S NP  TL +FL WRR  LL +  HD+AQL+TG SF G T+G+A 
Sbjct: 259 LVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAI 318

Query: 316 LMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHD---SADCCSASAADGGCIM 372
             ++CS   SGGVNMDHS + +GVA+++AHE+GH+ G+ HD   ++  C   A    CIM
Sbjct: 319 QNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIM 378

Query: 373 AAATGHPFPKVFNGCNRRELDRYLQSGGGMCL-SNMPDTRMLYGGRRCGNGYLEDGEECD 431
            A+T       F+ C+RR L++ L  G G CL   +P    +     CGN ++E GE+CD
Sbjct: 379 EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCD 436

Query: 432 CGEEEECNNPCCNASNCTLRPGAECAH-GSCCHQCKLLAPGTLCREQARQCDLPEFCTGK 490
           CG  ++C +PCC++  C LRPGA+CA  G CC  C+L   G  CR     CDLPEFC G 
Sbjct: 437 CGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGD 496

Query: 491 SPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDT 550
           S  CP +    DG PC GGQA C +G C +Y +QCQ LWGPGA+PA  LC +  N  G+ 
Sbjct: 497 SSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNA 556

Query: 551 FGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPID-TTIIMNGRQIQCRGTH 609
           FG+CG++ +G +  C  RDA CG++QCQ+   +PL  +   +   TI +NG ++ C   H
Sbjct: 557 FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVH 616

Query: 610 VYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQN 669
           +  G     D+  P L + GT CG   +C + +C+       + C  KC+GHGVC++N++
Sbjct: 617 LDLG----SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRH 672

Query: 670 CHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM----YYCCR 725
           C+C  GWAPP C T              ++   +  G+L+++LVL VL+++    +Y  R
Sbjct: 673 CYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQG-KRKVINTPEILR 784
            + +L QLK            +C +R +Q+  +    P  +    +G K   ++ P    
Sbjct: 721 LHQRLCQLKGP----------TCQYRAAQSGPSERPGPPQRALLARGTKASALSFPA--- 767

Query: 785 KPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPAP 844
               PP RP         PP P+   L     + P P +         RP P+ P+  +P
Sbjct: 768 ----PPSRP--------LPPDPVSKRLQAELADRPNPPT---------RPLPADPVVRSP 806

Query: 845 NCIVSQDFSRPRPPQKALPANPVPGR---RSLPRPGGASP 881
               SQ  ++P PP+K LPA+P  GR     LP PG   P
Sbjct: 807 K---SQGPAKPPPPRKPLPADP-QGRCPSGDLPGPGAGIP 842


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  512 bits (1319), Expect = e-145
 Identities = 328/919 (35%), Positives = 459/919 (49%), Gaps = 118/919 (12%)

Query: 16  ALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREK-------HPLKAELR 68
           A+ P RP A  E              Q+E+++P W+     VR         HP +    
Sbjct: 16  AIAPSRPWALME--------------QYEVVLP-WRLPGPRVRRALPSHLGLHPERVSYV 60

Query: 69  VMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVT 128
           + A G    L L KN  L    YTET+  ++G+  T   + +DHCFY G V     S+ +
Sbjct: 61  LGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAAS 120

Query: 129 LSTCRGIRGLITVSSNLSYVIEPLPDSK--GQHLIYRSEHLKPPPGNCGFEHSKPTTRDW 186
           LSTC G+RG   V S+L ++IEPL +    G+H +Y++EHL    G CG       +   
Sbjct: 121 LSTCAGLRGFFQVGSDL-HLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGS--- 176

Query: 187 ALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDK 246
            L        RPR          +YVELY+V D  EFQ     + A +H+++E+ N+VDK
Sbjct: 177 LLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQM-LGSEAAVRHRVLEVVNHVDK 235

Query: 247 FYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNAQLITGMS 305
            Y+ LN R+ LVGLE+W   +   VS +P  TL + L+W+ +   +++ HDN QLITG+ 
Sbjct: 236 LYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVD 295

Query: 306 FHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDS--ADC-CS 362
           F GTT+G A + AMCS + SG VN DHS+N +GVA TMAHEMGHN GM HD     C C 
Sbjct: 296 FTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQ 354

Query: 363 ASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNG 422
                G CIMA + G  FP++F+ C++  L+ +L+    +CL+N PD   L GG  CGN 
Sbjct: 355 ERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNL 414

Query: 423 YLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCD 482
           ++E GE+CDCG  E+C N CCN++ C L  GA+CAHG+CC +CK+   G LCR +   CD
Sbjct: 415 FVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCD 474

Query: 483 LPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFE 542
           L EFC G+ P CP + +Q +GTPC GG  YCYNG C T  +QCQ  WGPG + A + CF 
Sbjct: 475 LEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAEESCF- 531

Query: 543 KVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQ 602
               + D    C        +    R   CG +QC+  + +PL              GR 
Sbjct: 532 ----SYDILPGC--------KASRYRADMCGVLQCKGGQ-QPL--------------GRA 564

Query: 603 IQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHG 662
           I C     +    E+G   +P  V  GT+CG   +C++G+C++   + +  C  +C+ HG
Sbjct: 565 I-CIVDVCHALTTEDGTAYEP--VPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHG 621

Query: 663 VCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYY 722
           VCN+ Q CHC  GWAPP C          SG +P   V  VV  VL+A++++ +  ++ Y
Sbjct: 622 VCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLP---VFVVVVLVLLAVVLVTLAGIIVY 678

Query: 723 CCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEI 782
              ++  L +                   V+  +  G +NP F     +   K    P  
Sbjct: 679 RKARSRILSR------------------NVAPKTTMGRSNPLFHQAASRVPAKG-GAPAP 719

Query: 783 LRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIP- 841
            R P +  P   P        PA  PA  S  A   P P   +  T SS    P  P+P 
Sbjct: 720 SRGPQELVPTTHP------GQPARHPA--SSVALKRPPPAPPV--TVSS----PPFPVPV 765

Query: 842 ---PAPNCIVSQDFSRPRPPQK--ALPANPVPGRRSLPRPGGASPLRPP-----GAG-PQ 890
               AP  ++   F+ P PP K  A  ANP P   ++   G    L+PP     GA  PQ
Sbjct: 766 YTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAV---GPKVALKPPIQRKQGAELPQ 822

Query: 891 QSRPLAALAPKFPEYRSQR 909
             R   A   KF E  +++
Sbjct: 823 HPRGAPAPVWKFGEVAAEK 841


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  509 bits (1312), Expect = e-144
 Identities = 308/856 (35%), Positives = 449/856 (52%), Gaps = 91/856 (10%)

Query: 29  GWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAEL------RVMAEGRELILDLEK 82
           G T   +  S K   E + PQ    + P+  K  L+  L      ++  +G   IL+L +
Sbjct: 27  GGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQ 86

Query: 83  NEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVS 142
           N +L     T   Y   G    +     ++C Y G VR    S V++ TC G+RGL+ ++
Sbjct: 87  NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLT 146

Query: 143 SNLSYVIEPLP-DSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR-- 199
              SY +E  P D +G  +I R + L  P   C     +          TQ+  + P   
Sbjct: 147 PERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESV-------HTQKPPEHPLGQ 199

Query: 200 ---RMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIA 256
              R +R+ +   K VEL +VAD+ E QK R D     ++ +E+A  +D F+R LN+R+A
Sbjct: 200 RHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVALLLDTFFRPLNVRVA 258

Query: 257 LVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKYHDNAQLITGMSFHGTTIGLAP 315
           LVGLE WT  ++ E+S NP  TL +FL WRR  LL +  HD+AQL+TG SF G T+G+A 
Sbjct: 259 LVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAI 318

Query: 316 LMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHD---SADCCSASAADGGCIM 372
             ++CS   SGGVNMDHS + +GVA+++AHE+GH+ G+ HD   ++  C   A    CIM
Sbjct: 319 QNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIM 378

Query: 373 AAATGHPFPKVFNGCNRRELDRYLQSGGGMCL-SNMPDTRMLYGGRRCGNGYLEDGEECD 431
            A+T       F+ C+RR L++ L  G G CL   +P    +     CGN ++E GE+CD
Sbjct: 379 EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCD 436

Query: 432 CGEEEECNNPCCNASNCTLRPGAECAH-GSCCHQCKLLAPGTLCREQARQCDLPEFCTGK 490
           CG  ++C +PCC++  C LRPGA+CA  G CC  C+L   G  CR     CDLPEFC G 
Sbjct: 437 CGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGD 496

Query: 491 SPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDT 550
           S  CP +    DG PC GGQA C +G C +Y +QCQ LWGPGA+PA  LC +  N  G+ 
Sbjct: 497 SSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNA 556

Query: 551 FGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVP-IDTTIIMNGRQIQCRGTH 609
           FG+CG++ +G +  C  RDA CG++QCQ+   +PL  +    +  TI +NG ++ C   H
Sbjct: 557 FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVH 616

Query: 610 VYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQN 669
           +  G     D+  P L + GT CG   +C + +C+       + C  KC+GHGVC++N++
Sbjct: 617 LDLG----SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRH 672

Query: 670 CHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM----YYCCR 725
           C+C  GWAPP C T              ++   +  G+L+++LVL VL+++    +Y  R
Sbjct: 673 CYCEEGWAPPDCTT------------QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQG-KRKVINTPE--- 781
            + +L QLK            +C +R +Q+  +    P  +    +G K ++ + P    
Sbjct: 721 LHQRLCQLKGP----------TCQYRAAQSGPSERPGPPQRALLARGTKAELADRPNPPT 770

Query: 782 -------ILRKP-SQPPPRPPPDYLRGGSPPAPLPAHLSRAARNS--PGPGSQIERTESS 831
                  ++R P SQ P +PPP       P  PLPA       +   PGPG+ I      
Sbjct: 771 RPLPADPVVRSPKSQGPAKPPP-------PRKPLPADPQGRCPSGDLPGPGAGI------ 817

Query: 832 RRPP---PSRPIPPAP 844
             PP   PSRP PP P
Sbjct: 818 --PPLVVPSRPAPPPP 831



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 30/90 (33%), Positives = 37/90 (41%), Gaps = 24/90 (26%)

Query: 820 GPGSQIERTESSRRPPPSRPIPPAPNCIV----SQDFSRPRPPQKALPANPV-------- 867
           GP  Q    +S    P  RP PP    +     ++   RP PP + LPA+PV        
Sbjct: 730 GPTCQYRAAQSG---PSERPGPPQRALLARGTKAELADRPNPPTRPLPADPVVRSPKSQG 786

Query: 868 -----PGRRSLPR-PGGASP---LRPPGAG 888
                P R+ LP  P G  P   L  PGAG
Sbjct: 787 PAKPPPPRKPLPADPQGRCPSGDLPGPGAG 816


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  508 bits (1307), Expect = e-143
 Identities = 307/857 (35%), Positives = 444/857 (51%), Gaps = 92/857 (10%)

Query: 29  GWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAEL------RVMAEGRELILDLEK 82
           G T   +  S K   E + PQ    + P+  K  L+  L      ++  +G   IL+L +
Sbjct: 27  GGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQ 86

Query: 83  NEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVS 142
           N +L     T   Y   G    +     ++C Y G VR    S V++ TC G+RGL+ ++
Sbjct: 87  NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLT 146

Query: 143 SNLSYVIEPLP-DSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR-- 199
              SY +E  P D +G  +I R + L  P   C     +          TQ+  + P   
Sbjct: 147 PERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESV-------HTQKPPEHPLGQ 199

Query: 200 ---RMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIA 256
              R +R+ +   K VEL +VAD+ E QK R D     ++ +E+A  +D F+R LN+R+A
Sbjct: 200 RHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVALLLDTFFRPLNVRVA 258

Query: 257 LVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKYHDNAQLITGMSFHGTTIGLAP 315
           LVGLE WT  ++ E+S NP  TL +FL WRR  LL +  HD+AQL+TG SF G T+G+A 
Sbjct: 259 LVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAI 318

Query: 316 LMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHD---SADCCSASAADGGCIM 372
             ++CS   SGGVNMDHS + +GVA+++AHE+GH+ G+ HD   ++  C   A    CIM
Sbjct: 319 QNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIM 378

Query: 373 AAATGHPFPKVFNGCNRRELDRYLQSGGGMCL-SNMPDTRMLYGGRRCGNGYLEDGEECD 431
            A+T       F+ C+RR L++ L  G G CL   +P    +     CGN ++E GE+CD
Sbjct: 379 EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCD 436

Query: 432 CGEEEECNNPCCNASNCTLRPGAECAH-GSCCHQCKLLAPGTLCREQARQCDLPEFCTGK 490
           CG  ++C +PCC++  C LRPGA+CA  G CC  C+L   G  CR     CDLPEFC G 
Sbjct: 437 CGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGD 496

Query: 491 SPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDT 550
           S  CP +    DG PC GGQA C +G C +Y +QCQ LWGPGA+PA  LC +  N  G+ 
Sbjct: 497 SSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNA 556

Query: 551 FGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVP-IDTTIIMNGRQIQCRGTH 609
           FG+CG++ +G +  C  RDA CG++QCQ+   +PL  +    +  TI +NG ++ C   H
Sbjct: 557 FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVH 616

Query: 610 VYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQN 669
           +  G     D+  P L + GT CG   +C + +C+       + C  KC+GHGVC++N++
Sbjct: 617 LDLG----SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRH 672

Query: 670 CHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM----YYCCR 725
           C+C  GWAPP C T              ++   +  G+L+++LVL VL+++    +Y  R
Sbjct: 673 CYCEEGWAPPDCTT------------QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQG------------- 772
            + +L QLK            +C +R +Q+  +    P  +    +G             
Sbjct: 721 LHQRLCQLKGP----------TCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPP 770

Query: 773 KRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNS--PGPGSQIERTES 830
            R +   P   R  SQ P +PPP       P  PLPA       +   PGPG+ I     
Sbjct: 771 SRPLPPDPVSKRLQSQGPAKPPP-------PRKPLPADPQGRCPSGDLPGPGAGI----- 818

Query: 831 SRRPP---PSRPIPPAP 844
              PP   PSRP PP P
Sbjct: 819 ---PPLVVPSRPAPPPP 832



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 24/76 (31%), Positives = 29/76 (38%), Gaps = 2/76 (2%)

Query: 820 GPGSQIERTES--SRRPPPSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPG 877
           GP  Q    +S  S RP P +    A     +   S P PP + LP +PV  R     P 
Sbjct: 730 GPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVSKRLQSQGPA 789

Query: 878 GASPLRPPGAGPQQSR 893
              P R P     Q R
Sbjct: 790 KPPPPRKPLPADPQGR 805


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  508 bits (1307), Expect = e-143
 Identities = 304/844 (36%), Positives = 441/844 (52%), Gaps = 91/844 (10%)

Query: 29  GWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAEL------RVMAEGRELILDLEK 82
           G T   +  S K   E + PQ    + P+  K  L+  L      ++  +G   IL+L +
Sbjct: 27  GGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQ 86

Query: 83  NEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVS 142
           N +L     T   Y   G    +     ++C Y G VR    S V++ TC G+RGL+ ++
Sbjct: 87  NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLT 146

Query: 143 SNLSYVIEPLP-DSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR-- 199
              SY +E  P D +G  +I R + L  P   C     +          TQ+  + P   
Sbjct: 147 PERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESV-------HTQKPPEHPLGQ 199

Query: 200 ---RMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIA 256
              R +R+ +   K VEL +VAD+ E QK R D     ++ +E+A  +D F+R LN+R+A
Sbjct: 200 RHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVALLLDTFFRPLNVRVA 258

Query: 257 LVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKYHDNAQLITGMSFHGTTIGLAP 315
           LVGLE WT  ++ E+S NP  TL +FL WRR  LL +  HD+AQL+TG SF G T+G+A 
Sbjct: 259 LVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAI 318

Query: 316 LMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHD---SADCCSASAADGGCIM 372
             ++CS   SGGVNMDHS + +GVA+++AHE+GH+ G+ HD   ++  C   A    CIM
Sbjct: 319 QNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIM 378

Query: 373 AAATGHPFPKVFNGCNRRELDRYLQSGGGMCL-SNMPDTRMLYGGRRCGNGYLEDGEECD 431
            A+T       F+ C+RR L++ L  G G CL   +P    +     CGN ++E GE+CD
Sbjct: 379 EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCD 436

Query: 432 CGEEEECNNPCCNASNCTLRPGAECAH-GSCCHQCKLLAPGTLCREQARQCDLPEFCTGK 490
           CG  ++C +PCC++  C LRPGA+CA  G CC  C+L   G  CR     CDLPEFC G 
Sbjct: 437 CGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGD 496

Query: 491 SPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDT 550
           S  CP +    DG PC GGQA C +G C +Y +QCQ LWGPGA+PA  LC +  N  G+ 
Sbjct: 497 SSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNA 556

Query: 551 FGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVP-IDTTIIMNGRQIQCRGTH 609
           FG+CG++ +G +  C  RDA CG++QCQ+   +PL  +    +  TI +NG ++ C   H
Sbjct: 557 FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVH 616

Query: 610 VYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQN 669
           +  G     D+  P L + GT CG   +C + +C+       + C  KC+GHGVC++N++
Sbjct: 617 LDLG----SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRH 672

Query: 670 CHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM----YYCCR 725
           C+C  GWAPP C T              ++   +  G+L+++LVL VL+++    +Y  R
Sbjct: 673 CYCEEGWAPPDCTT------------QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRK 785
            + +L QLK            +C +R +Q+  +    P  +    +G +           
Sbjct: 721 LHQRLCQLKGP----------TCQYRAAQSGPSERPGPPQRALLARGTK----------- 759

Query: 786 PSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNS--PGPGSQIERTESSRRPP---PSRPI 840
            SQ P +PPP       P  PLPA       +   PGPG+ I        PP   PSRP 
Sbjct: 760 -SQGPAKPPP-------PRKPLPADPQGRCPSGDLPGPGAGI--------PPLVVPSRPA 803

Query: 841 PPAP 844
           PP P
Sbjct: 804 PPPP 807



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 26/69 (37%), Positives = 32/69 (46%), Gaps = 11/69 (15%)

Query: 820 GPGSQIERTESSRRPPPSRPIPPAPNCIV----SQDFSRPRPPQKALPANPVPGR---RS 872
           GP  Q    +S    P  RP PP    +     SQ  ++P PP+K LPA+P  GR     
Sbjct: 730 GPTCQYRAAQSG---PSERPGPPQRALLARGTKSQGPAKPPPPRKPLPADP-QGRCPSGD 785

Query: 873 LPRPGGASP 881
           LP PG   P
Sbjct: 786 LPGPGAGIP 794



 Score = 31.2 bits (69), Expect = 4.6
 Identities = 22/48 (45%), Positives = 24/48 (50%), Gaps = 13/48 (27%)

Query: 854 RPRPPQKAL---------PANPVPGRRSLPR-PGGASP---LRPPGAG 888
           RP PPQ+AL         PA P P R+ LP  P G  P   L  PGAG
Sbjct: 745 RPGPPQRALLARGTKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG 792


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  497 bits (1280), Expect = e-140
 Identities = 314/876 (35%), Positives = 442/876 (50%), Gaps = 84/876 (9%)

Query: 2   PGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREKH 61
           P G    R  LL   + P+    A  PG+ + S   S    +E+I P W+ +        
Sbjct: 8   PSGTLRVRWLLLLGLVGPVL--GAARPGFQQTSHLSS----YEIITP-WRLTRERREAPR 60

Query: 62  PLKAELR--VMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTV 119
           P   ++   + AEG+E I+ LE+N+ L    +    Y   G   T    +++HC Y G V
Sbjct: 61  PYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYV 120

Query: 120 RETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKG-QHLIYRSEHLKPPPGNCGFEH 178
                SS+ LS C G+RGL+ +  N SY IEPL +S   +H+IYR + +   P  CG  +
Sbjct: 121 EGVHNSSIALSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSN 179

Query: 179 S---KPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKH 235
               K T +D   +    T+   RR  R  L   +YVEL++V D   +    R+Q A + 
Sbjct: 180 KDIEKETAKDEEEEPPSMTQLLRRR--RAVLPQTRYVELFIVVDKERYDMMGRNQTAVRE 237

Query: 236 KLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKY 294
           ++I +ANY+D  Y  LNIRI LVGLE+WT+GN+  +       L +F+ WR K L+ ++ 
Sbjct: 238 EMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRR 297

Query: 295 HDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMT 354
           HD+AQL+    F GT  G+A +  +CS   +GG+N+         A+ +AHE+GHN GM 
Sbjct: 298 HDSAQLVLKKGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMN 356

Query: 355 HDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLY 414
           HD    CS  A    CIM +  G    + F+ C+  + ++   + GG CL N+P     Y
Sbjct: 357 HDDGRDCSCGAKS--CIMNS--GASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAY 412

Query: 415 GGRRCGNGYLEDGEECDCGEEEECN-NPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTL 473
               CGN  ++ GEECDCG  +EC  +PCC  S C L+  AECA+G CC  C+ L  GTL
Sbjct: 413 SAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTL 472

Query: 474 CREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGA 533
           CR +  +CD+PE+C G S  C  + +  +G PC+  +AYCYNGMC  Y  QCQ ++G  A
Sbjct: 473 CRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKA 532

Query: 534 RPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPID 593
           + AP  CF +VN  GD FGNCG   N E++KC   +A CGK+QC++ +  P+      I 
Sbjct: 533 KAAPKDCFIEVNSKGDRFGNCGFSGN-EYKKCATGNALCGKLQCENVQEIPVFGIVPAII 591

Query: 594 TTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETE- 652
            T     R  +C G     G     D+ DPG+V  GTKCG   IC   QC + S    + 
Sbjct: 592 QT---PSRGTKCWGVDFQLG----SDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDC 644

Query: 653 GCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLV--- 709
              KKC+GHGVCN+N+NCHC  GWAPP C T G+GGS+DSGP   E    +  G+LV   
Sbjct: 645 DVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFF 704

Query: 710 AILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQT 769
            I+ L V  +  +  R      QL  S    K  Q +       ++ G   ANP+     
Sbjct: 705 LIVPLIVCAIFIFIKRD-----QLWRSYFRKKRSQTY-------ESDGKNQANPS----- 747

Query: 770 PQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTE 829
                         R+P   P    P      +PP  +P + +R A            T 
Sbjct: 748 --------------RQPGSVPRHVSPV-----TPPREVPIYANRFA----------VPTY 778

Query: 830 SSRRPP--PSRPIPPAPNCIVSQDFSRPRPPQKALP 863
           ++++P   PSRP PP P  + SQ    P  P  A P
Sbjct: 779 AAKQPQQFPSRPPPPQPK-VSSQGNLIPARPAPAPP 813


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score =  488 bits (1256), Expect = e-137
 Identities = 277/740 (37%), Positives = 403/740 (54%), Gaps = 49/740 (6%)

Query: 29  GWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAEL------RVMAEGRELILDLEK 82
           G T   +  S K   E + PQ    + P+  K  L+  L      ++  +G   IL+L +
Sbjct: 27  GGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQ 86

Query: 83  NEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVS 142
           N +L     T   Y   G    +     ++C Y G VR    S V++ TC G+RGL+ ++
Sbjct: 87  NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLT 146

Query: 143 SNLSYVIEPLP-DSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR-- 199
              SY +E  P D +G  +I R + L  P   C     +          TQ+  + P   
Sbjct: 147 PERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESV-------HTQKPPEHPLGQ 199

Query: 200 ---RMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIA 256
              R +R+ +   K VEL +VAD+ E QK R D     ++ +E+A  +D F+R LN+R+A
Sbjct: 200 RHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVALLLDTFFRPLNVRVA 258

Query: 257 LVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKYHDNAQLITGMSFHGTTIGLAP 315
           LVGLE WT  ++ E+S NP  TL +FL WRR  LL +  HD+AQL+TG SF G T+G+A 
Sbjct: 259 LVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAI 318

Query: 316 LMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHD---SADCCSASAADGGCIM 372
             ++CS   SGGVNMDHS + +GVA+++AHE+GH+ G+ HD   ++  C   A    CIM
Sbjct: 319 QNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIM 378

Query: 373 AAATGHPFPKVFNGCNRRELDRYLQSGGGMCL-SNMPDTRMLYGGRRCGNGYLEDGEECD 431
            A+T       F+ C+RR L++ L  G G CL   +P    +     CGN ++E GE+CD
Sbjct: 379 EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCD 436

Query: 432 CGEEEECNNPCCNASNCTLRPGAECAH-GSCCHQCKLLAPGTLCREQARQCDLPEFCTGK 490
           CG  ++C +PCC++  C LRPGA+CA  G CC  C+L   G  CR     CDLPEFC G 
Sbjct: 437 CGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGD 496

Query: 491 SPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDT 550
           S  CP +    DG PC GGQA C +G C +Y +QCQ LWGPGA+PA  LC +  N  G+ 
Sbjct: 497 SSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNA 556

Query: 551 FGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVP-IDTTIIMNGRQIQCRGTH 609
           FG+CG++ +G +  C  RDA CG++QCQ+   +PL  +    +  TI +NG ++ C   H
Sbjct: 557 FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVH 616

Query: 610 VYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQN 669
           +  G     D+  P L + GT CG   +C + +C+       + C  KC+GHGVC++N++
Sbjct: 617 LDLG----SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRH 672

Query: 670 CHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM----YYCCR 725
           C+C  GWAPP C T              ++   +  G+L+++LVL VL+++    +Y  R
Sbjct: 673 CYCEEGWAPPDCTT------------QLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720

Query: 726 QNNKLGQLKPSALPSKLRQQ 745
            + +L QLK       LR Q
Sbjct: 721 LHQRLCQLKGPTCQYSLRGQ 740


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  437 bits (1124), Expect = e-122
 Identities = 244/705 (34%), Positives = 365/705 (51%), Gaps = 45/705 (6%)

Query: 51  KTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLE 110
           +  E   +E+   + + ++   G+  +L L+KN+ L AP YTET+Y S+G   TT+ ++ 
Sbjct: 43  EAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIM 102

Query: 111 DHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLP----DSKGQHLIYRSEH 166
           D C+Y G +   ++S  ++STCRG+RG  +   +  Y IEPL     D +   L   +  
Sbjct: 103 DDCYYQGHILNEKVSDASISTCRGLRGYFS-QGDQRYFIEPLSPIHRDGQEHALFKYNPD 161

Query: 167 LKPPPGNCGFEH---SKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEF 223
            K     CG +    +    ++ AL  T+  K + R+++  +    KY+E YLV D  EF
Sbjct: 162 EKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHE----KYIEYYLVLDNGEF 217

Query: 224 QKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFL 283
           ++   +QD  + ++ E+ANYV+  Y+ LN  +ALVG+E+WT  +  +++ N   TL +F 
Sbjct: 218 KRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFS 277

Query: 284 SWRRKLLAQ-KYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAAT 342
            WR  +L++ K HD AQLIT     GTT+GLA +  MCS Y S GV  DHS+N + VA T
Sbjct: 278 KWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGT 336

Query: 343 MAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGM 402
           MAHEMGHNFGM HD   C   S     C+M  A     P  F+ C+R   D++ +     
Sbjct: 337 MAHEMGHNFGMFHDDYSCKCPSTI---CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSN 393

Query: 403 CLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCC 462
           CL N P    +     CGN  +E GE+CDCG  EEC N CC+A  C ++   +CA G CC
Sbjct: 394 CLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECC 453

Query: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522
            +C+    G +CR    +CDLPE C GKS +CP + +Q++G PC  G+ +C  G C T Q
Sbjct: 454 EKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQ 513

Query: 523 EQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQ-SSE 581
           EQC +LWGPG   A   C+ + N  G  +G C + ++     C   D  CGK+ CQ  S+
Sbjct: 514 EQCTELWGPGTEVADKSCYNR-NEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQGGSD 571

Query: 582 ARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEG 641
             P +   V   T    +              PE+    +  G+V  GTKCG N +C   
Sbjct: 572 NLPWKGRIVTFLTCKTFD--------------PEDTSQEI--GMVANGTKCGDNKVCINA 615

Query: 642 QCRN-TSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESV 700
           +C +    +++  C  KC GH VC++   C C  GW PP C+        DS  +   S+
Sbjct: 616 ECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCD--------DSSVVFHFSI 667

Query: 701 GPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQ 745
              V   +  I V+  +++ +   R+  K  Q   S   ++  +Q
Sbjct: 668 VVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQ 712


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  382 bits (981), Expect = e-106
 Identities = 210/661 (31%), Positives = 339/661 (51%), Gaps = 43/661 (6%)

Query: 74  RELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCR 133
           + L+L L ++ +    +Y+ET Y+  G   T   ++ DHCFY G++     S+ ++STC 
Sbjct: 68  KTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCN 127

Query: 134 GIRGLITVSSNLSYVIEPLPDS-KGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQ 192
           G+RG   ++    Y+IEP+  S +G+HL+++     P   N              L FT+
Sbjct: 128 GLRGFFRINDQ-RYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTE---------LNFTR 177

Query: 193 QT----KKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248
           +T     +     K + ++  KYVEL++VAD   +++N    +  ++++  + N+V+  Y
Sbjct: 178 KTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIY 237

Query: 249 RSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLL-AQKYHDNAQLITGMSFH 307
           ++LNI + LVG+E+WTH +  E+  N  +TL  F  W+ K+L  +K  D+  L++G   +
Sbjct: 238 KTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLY 297

Query: 308 GTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAAD 367
               G++    MC  Y S  +  D   +   +A  MAH++GHN GM HD   C   S   
Sbjct: 298 SHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPS--- 354

Query: 368 GGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDG 427
           G C+M +    P  K F+ C++ +  +YL+     C+ N+P     +  + CGN  L++G
Sbjct: 355 GKCVMDSDGSIPALK-FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEG 413

Query: 428 EECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPEFC 487
           EECDCG  +EC NPCC+A  C L+PG  CA G CC  C++   G++CR    +CD PE C
Sbjct: 414 EECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMC 473

Query: 488 TGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVA 547
           TG SP CP + ++++G PC+  + YC+ G C T ++QC +L+   A  + D+C+ K+N  
Sbjct: 474 TGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICY-KMNTK 532

Query: 548 GDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRG 607
           G+ FG C K+       C  +D +CGKI C   E   L                 ++C+ 
Sbjct: 533 GNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKT 591

Query: 608 THVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRN-TSFFETEGCGKKCNGHGVCNN 666
             +Y       D  D GLV +GTKCG   +C  G+C N    + +  C  +CN + V  +
Sbjct: 592 IFLYH------DSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGH 645

Query: 667 NQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILV---LAVLMLMYYC 723
              CHC  G AP  C    H  +I            ++  VLV ++V   + +L++ Y  
Sbjct: 646 GLQCHCEEGQAPVACEETLHVTNI-----------TILVVVLVLVIVGIGVLILLVRYRK 694

Query: 724 C 724
           C
Sbjct: 695 C 695


>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
           [Homo sapiens]
          Length = 540

 Score =  370 bits (951), Expect = e-102
 Identities = 193/498 (38%), Positives = 280/498 (56%), Gaps = 17/498 (3%)

Query: 51  KTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLE 110
           +  E   +E+   + + ++   G+  +L L+KN+ L AP YTET+Y S+G   TT+ ++ 
Sbjct: 43  EAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIM 102

Query: 111 DHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLP----DSKGQHLIYRSEH 166
           D C+Y G +   ++S  ++STCRG+RG  +   +  Y IEPL     D +   L   +  
Sbjct: 103 DDCYYQGHILNEKVSDASISTCRGLRGYFS-QGDQRYFIEPLSPIHRDGQEHALFKYNPD 161

Query: 167 LKPPPGNCGFEH---SKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEF 223
            K     CG +    +    ++ AL  T+  K + R+++  +    KY+E YLV D  EF
Sbjct: 162 EKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHE----KYIEYYLVLDNGEF 217

Query: 224 QKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFL 283
           ++   +QD  + ++ E+ANYV+  Y+ LN  +ALVG+E+WT  +  +++ N   TL +F 
Sbjct: 218 KRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFS 277

Query: 284 SWRRKLLAQ-KYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAAT 342
            WR  +L++ K HD AQLIT     GTT+GLA +  MCS Y S GV  DHS+N + VA T
Sbjct: 278 KWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGT 336

Query: 343 MAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGM 402
           MAHEMGHNFGM HD   C   S     C+M  A     P  F+ C+R   D++ +     
Sbjct: 337 MAHEMGHNFGMFHDDYSCKCPSTI---CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSN 393

Query: 403 CLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCC 462
           CL N P    +     CGN  +E GE+CDCG  EEC N CC+A  C ++   +CA G CC
Sbjct: 394 CLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECC 453

Query: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522
            +C+    G +CR    +CDLPE C GKS +CP + +Q++G PC  G+ +C  G C T Q
Sbjct: 454 EKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQ 513

Query: 523 EQCQQLWGPGARPAPDLC 540
           EQC +LWGPG R  P  C
Sbjct: 514 EQCTELWGPGRRTNPFPC 531


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  368 bits (945), Expect = e-101
 Identities = 238/706 (33%), Positives = 331/706 (46%), Gaps = 53/706 (7%)

Query: 61  HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120
           H  +A  +V A G   ILD+  N  L +  Y E H    G  +T   K  +HC+Y G +R
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGG--KTVEVKGGEHCYYQGHIR 142

Query: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQ-----HLIYRSE----HLKPPP 171
               S V LSTC G+ G+     N +Y+IEP  +   Q     H +Y+S      L   P
Sbjct: 143 GNPDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201

Query: 172 GNCGFEHSKPTTRDWALQ-FTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQ 230
               F+    T   + L+   +++K++ RR  R      KY+EL +V D+L F+K+R   
Sbjct: 202 SE--FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 231 DATKHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKL 289
             T      + N  D  Y+  L  RI LV +E W   N   +SENP  TL  F+ +RR  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 290 LAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGH 349
           + +K  D   L +G  F  +  G A +  +CS+ + GGVN     + + V  T+A  + H
Sbjct: 320 IKEK-SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAH 376

Query: 350 NFGMTHDSADC----CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLS 405
           N G+  D        C       GCIM   TG+  PK F  CN  E   +L SGGG CL 
Sbjct: 377 NIGIISDKRKLASGECKCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLF 435

Query: 406 NMPDTRMLYGGRRCGNGYLEDGEECDCGEEEEC---NNPCCNASNCTLRPGAECAHGSCC 462
           N P    L     CGNG++E GEECDCG   EC      CC    CTL   ++C+ G CC
Sbjct: 436 NKPSK--LLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQCSDGLCC 491

Query: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522
            +CK    GT+CRE    CD+ E C+G S  C  N ++MDG  C+G Q  C+ G C T  
Sbjct: 492 KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRD 551

Query: 523 EQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEA 582
            QC+ +WG     +   C+EK+N+ G   GNCGKD +    +CN RD  CG + C +   
Sbjct: 552 RQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGN 610

Query: 583 RPL--ESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFE 640
            P   E +     T ++  GR + C G HV    EE+ D+   G V  GT CG   +C E
Sbjct: 611 IPRLGELDGEITSTLVVQQGRTLNCSGGHVKL--EEDVDL---GYVEDGTPCGPQMMCLE 665

Query: 641 GQCRNTSFFETEGC-----GKKCNGHGVCNNNQNCHCLPGWAPPFCNTP-GHGGSIDSGP 694
            +C   + F    C     G  C+G+GVC+N   C C   W    CNT   H     +G 
Sbjct: 666 HRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGI 725

Query: 695 MPPES--------VGPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQ 732
               +        +G +   +LV  L+L +    Y   R+  +L Q
Sbjct: 726 TLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQ 771


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  368 bits (945), Expect = e-101
 Identities = 254/785 (32%), Positives = 355/785 (45%), Gaps = 57/785 (7%)

Query: 61  HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120
           H  +A  +V A G   ILD+  N  L +  Y E H    G  +T   K  +HC+Y G +R
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGG--KTVEVKGGEHCYYQGHIR 142

Query: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQ-----HLIYRSE----HLKPPP 171
               S V LSTC G+ G+     N +Y+IEP  +   Q     H +Y+S      L   P
Sbjct: 143 GNPDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201

Query: 172 GNCGFEHSKPTTRDWALQ-FTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQ 230
               F+    T   + L+   +++K++ RR  R      KY+EL +V D+L F+K+R   
Sbjct: 202 SE--FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 231 DATKHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKL 289
             T      + N  D  Y+  L  RI LV +E W   N   +SENP  TL  F+ +RR  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 290 LAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGH 349
           + +K  D   L +G  F  +  G A +  +CS+ + GGVN     + + V  T+A  + H
Sbjct: 320 IKEK-SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAH 376

Query: 350 NFGMTHDSADC----CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLS 405
           N G+  D        C       GCIM   TG+  PK F  CN  E   +L SGGG CL 
Sbjct: 377 NIGIISDKRKLASGECKCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLF 435

Query: 406 NMPDTRMLYGGRRCGNGYLEDGEECDCGEEEEC---NNPCCNASNCTLRPGAECAHGSCC 462
           N P    L     CGNG++E GEECDCG   EC      CC    CTL   ++C+ G CC
Sbjct: 436 NKPSK--LLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQCSDGLCC 491

Query: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522
            +CK    GT+CRE    CD+ E C+G S  C  N ++MDG  C+G Q  C+ G C T  
Sbjct: 492 KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRD 551

Query: 523 EQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEA 582
            QC+ +WG     +   C+EK+N+ G   GNCGKD +    +CN RD  CG + C +   
Sbjct: 552 RQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGN 610

Query: 583 RPL--ESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFE 640
            P   E +     T ++  GR + C G HV    EE+ D+   G V  GT CG   +C E
Sbjct: 611 IPRLGELDGEITSTLVVQQGRTLNCSGGHVKL--EEDVDL---GYVEDGTPCGPQMMCLE 665

Query: 641 GQCRNTSFFETEGC-----GKKCNGHGVCNNNQNCHCLPGWAPPFCNTP-GHGGSIDSGP 694
            +C   + F    C     G  C+G+GVC+N   C C   W    CNT   H     +G 
Sbjct: 666 HRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGI 725

Query: 695 MPPES--------VGPVVAGVLVAILVLAVLMLMY--YCCRQNNKLGQLKPSALPSKLRQ 744
               +        +G +   +LV  L+L +    Y  Y  +++N L       +P     
Sbjct: 726 TLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIPDTKHI 785

Query: 745 QFSCP-FRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSP 803
              C   R   NS  G+     K    +  R   N+ E L  P++ P             
Sbjct: 786 SDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTETL-SPAKSPSSSTGSIASSRKY 844

Query: 804 PAPLP 808
           P P+P
Sbjct: 845 PYPMP 849


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score =  368 bits (945), Expect = e-101
 Identities = 238/706 (33%), Positives = 331/706 (46%), Gaps = 53/706 (7%)

Query: 61  HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120
           H  +A  +V A G   ILD+  N  L +  Y E H    G  +T   K  +HC+Y G +R
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGG--KTVEVKGGEHCYYQGHIR 142

Query: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQ-----HLIYRSE----HLKPPP 171
               S V LSTC G+ G+     N +Y+IEP  +   Q     H +Y+S      L   P
Sbjct: 143 GNPDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201

Query: 172 GNCGFEHSKPTTRDWALQ-FTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQ 230
               F+    T   + L+   +++K++ RR  R      KY+EL +V D+L F+K+R   
Sbjct: 202 SE--FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 231 DATKHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKL 289
             T      + N  D  Y+  L  RI LV +E W   N   +SENP  TL  F+ +RR  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 290 LAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGH 349
           + +K  D   L +G  F  +  G A +  +CS+ + GGVN     + + V  T+A  + H
Sbjct: 320 IKEK-SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAH 376

Query: 350 NFGMTHDSADC----CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLS 405
           N G+  D        C       GCIM   TG+  PK F  CN  E   +L SGGG CL 
Sbjct: 377 NIGIISDKRKLASGECKCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLF 435

Query: 406 NMPDTRMLYGGRRCGNGYLEDGEECDCGEEEEC---NNPCCNASNCTLRPGAECAHGSCC 462
           N P    L     CGNG++E GEECDCG   EC      CC    CTL   ++C+ G CC
Sbjct: 436 NKPSK--LLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQCSDGLCC 491

Query: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522
            +CK    GT+CRE    CD+ E C+G S  C  N ++MDG  C+G Q  C+ G C T  
Sbjct: 492 KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRD 551

Query: 523 EQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEA 582
            QC+ +WG     +   C+EK+N+ G   GNCGKD +    +CN RD  CG + C +   
Sbjct: 552 RQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGN 610

Query: 583 RPL--ESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFE 640
            P   E +     T ++  GR + C G HV    EE+ D+   G V  GT CG   +C E
Sbjct: 611 IPRLGELDGEITSTLVVQQGRTLNCSGGHVKL--EEDVDL---GYVEDGTPCGPQMMCLE 665

Query: 641 GQCRNTSFFETEGC-----GKKCNGHGVCNNNQNCHCLPGWAPPFCNTP-GHGGSIDSGP 694
            +C   + F    C     G  C+G+GVC+N   C C   W    CNT   H     +G 
Sbjct: 666 HRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGI 725

Query: 695 MPPES--------VGPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQ 732
               +        +G +   +LV  L+L +    Y   R+  +L Q
Sbjct: 726 TLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQ 771


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  366 bits (940), Expect = e-101
 Identities = 227/648 (35%), Positives = 311/648 (47%), Gaps = 44/648 (6%)

Query: 61  HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120
           H  +A  +V A G   ILD+  N  L +  Y E H    G  +T   K  +HC+Y G +R
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGG--KTVEVKGGEHCYYQGHIR 142

Query: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQ-----HLIYRSE----HLKPPP 171
               S V LSTC G+ G+     N +Y+IEP  +   Q     H +Y+S      L   P
Sbjct: 143 GNPDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201

Query: 172 GNCGFEHSKPTTRDWALQ-FTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQ 230
               F+    T   + L+   +++K++ RR  R      KY+EL +V D+L F+K+R   
Sbjct: 202 SE--FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 231 DATKHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKL 289
             T      + N  D  Y+  L  RI LV +E W   N   +SENP  TL  F+ +RR  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 290 LAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGH 349
           + +K  D   L +G  F  +  G A +  +CS+ + GGVN     + + V  T+A  + H
Sbjct: 320 IKEK-SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAH 376

Query: 350 NFGMTHDSADC----CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLS 405
           N G+  D        C       GCIM   TG+  PK F  CN  E   +L SGGG CL 
Sbjct: 377 NIGIISDKRKLASGECKCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLF 435

Query: 406 NMPDTRMLYGGRRCGNGYLEDGEECDCGEEEEC---NNPCCNASNCTLRPGAECAHGSCC 462
           N P    L     CGNG++E GEECDCG   EC      CC    CTL   ++C+ G CC
Sbjct: 436 NKPSK--LLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQCSDGLCC 491

Query: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522
            +CK    GT+CRE    CD+ E C+G S  C  N ++MDG  C+G Q  C+ G C T  
Sbjct: 492 KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRD 551

Query: 523 EQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEA 582
            QC+ +WG     +   C+EK+N+ G   GNCGKD +    +CN RD  CG + C +   
Sbjct: 552 RQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGN 610

Query: 583 RPL--ESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFE 640
            P   E +     T ++  GR + C G HV    EE+ D+   G V  GT CG   +C E
Sbjct: 611 IPRLGELDGEITSTLVVQQGRTLNCSGGHVKL--EEDVDL---GYVEDGTPCGPQMMCLE 665

Query: 641 GQCRNTSFFETEGC-----GKKCNGHGVCNNNQNCHCLPGWAPPFCNT 683
            +C   + F    C     G  C+G+GVC+N   C C   W    CNT
Sbjct: 666 HRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNT 713


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  366 bits (940), Expect = e-101
 Identities = 227/648 (35%), Positives = 311/648 (47%), Gaps = 44/648 (6%)

Query: 61  HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120
           H  +A  +V A G   ILD+  N  L +  Y E H    G  +T   K  +HC+Y G +R
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGG--KTVEVKGGEHCYYQGHIR 142

Query: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQ-----HLIYRSE----HLKPPP 171
               S V LSTC G+ G+     N +Y+IEP  +   Q     H +Y+S      L   P
Sbjct: 143 GNPDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201

Query: 172 GNCGFEHSKPTTRDWALQ-FTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQ 230
               F+    T   + L+   +++K++ RR  R      KY+EL +V D+L F+K+R   
Sbjct: 202 SE--FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 231 DATKHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKL 289
             T      + N  D  Y+  L  RI LV +E W   N   +SENP  TL  F+ +RR  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 290 LAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGH 349
           + +K  D   L +G  F  +  G A +  +CS+ + GGVN     + + V  T+A  + H
Sbjct: 320 IKEK-SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAH 376

Query: 350 NFGMTHDSADC----CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLS 405
           N G+  D        C       GCIM   TG+  PK F  CN  E   +L SGGG CL 
Sbjct: 377 NIGIISDKRKLASGECKCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLF 435

Query: 406 NMPDTRMLYGGRRCGNGYLEDGEECDCGEEEEC---NNPCCNASNCTLRPGAECAHGSCC 462
           N P    L     CGNG++E GEECDCG   EC      CC    CTL   ++C+ G CC
Sbjct: 436 NKPSK--LLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQCSDGLCC 491

Query: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522
            +CK    GT+CRE    CD+ E C+G S  C  N ++MDG  C+G Q  C+ G C T  
Sbjct: 492 KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRD 551

Query: 523 EQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEA 582
            QC+ +WG     +   C+EK+N+ G   GNCGKD +    +CN RD  CG + C +   
Sbjct: 552 RQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGN 610

Query: 583 RPL--ESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFE 640
            P   E +     T ++  GR + C G HV    EE+ D+   G V  GT CG   +C E
Sbjct: 611 IPRLGELDGEITSTLVVQQGRTLNCSGGHVKL--EEDVDL---GYVEDGTPCGPQMMCLE 665

Query: 641 GQCRNTSFFETEGC-----GKKCNGHGVCNNNQNCHCLPGWAPPFCNT 683
            +C   + F    C     G  C+G+GVC+N   C C   W    CNT
Sbjct: 666 HRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNT 713


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  361 bits (927), Expect = 1e-99
 Identities = 224/684 (32%), Positives = 327/684 (47%), Gaps = 47/684 (6%)

Query: 61  HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120
           H  +A  ++ A G + ILDL  N  L +  Y E HY  +G PQ +  K  +HC+YHG++R
Sbjct: 147 HLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHY-ENGKPQYS--KGGEHCYYHGSIR 203

Query: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSK 180
             + S V LSTC G+ G+        Y+IEPL     +    R   ++        +  K
Sbjct: 204 GVKDSKVALSTCNGLHGMFE-DDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMK 262

Query: 181 PTTRD----WALQFTQQTKKRPRRM---KREDLNSMKYVELYLVADYLEFQKNRRDQDAT 233
             T +    W      Q  KR +R     R     MKY+EL +V D+  ++K+R     T
Sbjct: 263 NLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHT 322

Query: 234 KHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQ 292
            +    + N VD  Y+  LN R+ LV +E WT  +  +++ NP   L  F  +R+++  +
Sbjct: 323 NNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI--K 380

Query: 293 KYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFG 352
           ++ D   LI+ ++FH     L+    +CS  ++ GV ++     + VA  ++  +  N G
Sbjct: 381 QHADAVHLISRVTFHYKRSSLSYFGGVCS--RTRGVGVNEYGLPMAVAQVLSQSLAQNLG 438

Query: 353 MTHDSADC---CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPD 409
           +  + +     C  + + GGCIM   TG    + F+ C+  E   +LQ GGG CL N P 
Sbjct: 439 IQWEPSSRKPKCDCTESWGGCIMEE-TGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPT 497

Query: 410 TRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQ--CKL 467
              L+    CGNGY+E GEECDCG   EC   CC    C+L  GA C+ G CC+   C  
Sbjct: 498 K--LFEPTECGNGYVEAGEECDCGFHVECYGLCCK--KCSLSNGAHCSDGPCCNNTSCLF 553

Query: 468 LAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQ 527
              G  CR+   +CD+ E+CTG S  CP N ++ DG  C   Q  CYNG C T   QCQ 
Sbjct: 554 QPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQY 613

Query: 528 LWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARP--- 584
           +WG  A  +   C+EK+N  G   GNCGKD      +C+  D  CG + C +    P   
Sbjct: 614 IWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPRIG 672

Query: 585 -LESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQC 643
            L+   +P  T+    GR I C G HV        D  D G V  GT CG + +C + +C
Sbjct: 673 QLQGEIIP--TSFYHQGRVIDCSGAHVVL-----DDDTDVGYVEDGTPCGPSMMCLDRKC 725

Query: 644 RNTSFFETEGC-----GKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSI----DSGP 694
                     C     GK C+GHGVC+N   C C   WA   C+      ++    D GP
Sbjct: 726 LQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGP 785

Query: 695 MPPESVGPVVAGVLVAILVLAVLM 718
             P +   ++  +  AILV A+++
Sbjct: 786 KGPSATNLIIGSIAGAILVAAIVL 809


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  361 bits (926), Expect = 2e-99
 Identities = 244/821 (29%), Positives = 386/821 (47%), Gaps = 70/821 (8%)

Query: 73  GRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTC 132
           G++ I+ ++  + LF+       YT  G        ++++C+YHG V     S V+LSTC
Sbjct: 60  GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119

Query: 133 -RGIRGLITVSSNLSYVIEPLPDSKG-QHLIYR--SEHLKPPPGNCGFEHSKPTTRDWAL 188
             G +G++ ++ + +Y I+PL  S   +HL+Y+  SE  +      GF  ++ T R    
Sbjct: 120 FGGFQGILQIN-DFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFE 178

Query: 189 QFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248
           +    T+K+   +        + VE+ +V D   + +  R+       L  I N VD   
Sbjct: 179 EIDNSTQKQSSYVGW--WIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL 236

Query: 249 RSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNAQLITGMSFH 307
             + +++ L GLE+WT+ N+  V ++   ++  +  W+ + +  +  HD + L T +   
Sbjct: 237 DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLR 295

Query: 308 GTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC-CSASAA 366
           G + G+     MC+ ++S  +    ++     +  +AH +GHN GM HD   C CS    
Sbjct: 296 GLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPR- 353

Query: 367 DGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLED 426
              CIM    G+P    F+ C+  +   Y       CL     T+ ++  +RCGNG +E+
Sbjct: 354 ---CIMHE--GNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEE 407

Query: 427 GEECDCGEEEEC-NNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPE 485
           GEECDCG  + C  +PCC  SNCTL  G+ CA G CC  CK L  G +CR++  +CDLPE
Sbjct: 408 GEECDCGPLKHCAKDPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPE 466

Query: 486 FCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVN 545
           +C G S  CP +FY  DG PC+  + YCY   C    EQC++++G GA  A + C++++N
Sbjct: 467 WCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELN 525

Query: 546 VAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQC 605
             GD  G+CG   N  + KCN+ D +CG+IQC++    P  S+   +          I C
Sbjct: 526 TLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA---RFNDIMC 581

Query: 606 RGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCN 665
             T  + G +      D G V  GT+CG +HIC    C + +   +      CN  G+CN
Sbjct: 582 WSTDYHLGMKGP----DIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICN 637

Query: 666 NNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCR 725
           N  +CHC   W PP C   G+GGS+DSGP P          + + +L++  ++L   CC 
Sbjct: 638 NKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL---CC- 693

Query: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRK 785
               L +L   + P K +Q                      +QTP  K +     +I R+
Sbjct: 694 ----LYRLCKKSKPIKKQQD---------------------VQTPSAKEE----EKIQRR 724

Query: 786 PSQPPPRPPPDYLRGGSPP--APLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPA 843
           P + PP+  P  +   S P   P  +H       S  P   +  ++S  R  PS+  PP 
Sbjct: 725 PHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPP---VTPSQSQPRVMPSQSQPPV 781

Query: 844 PNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRP 884
              + SQ   +  P Q   P  P   +  L       P+ P
Sbjct: 782 ---MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTP 819


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  361 bits (926), Expect = 2e-99
 Identities = 244/821 (29%), Positives = 386/821 (47%), Gaps = 70/821 (8%)

Query: 73  GRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTC 132
           G++ I+ ++  + LF+       YT  G        ++++C+YHG V     S V+LSTC
Sbjct: 60  GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119

Query: 133 -RGIRGLITVSSNLSYVIEPLPDSKG-QHLIYR--SEHLKPPPGNCGFEHSKPTTRDWAL 188
             G +G++ ++ + +Y I+PL  S   +HL+Y+  SE  +      GF  ++ T R    
Sbjct: 120 FGGFQGILQIN-DFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFE 178

Query: 189 QFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248
           +    T+K+   +        + VE+ +V D   + +  R+       L  I N VD   
Sbjct: 179 EIDNSTQKQSSYVGW--WIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL 236

Query: 249 RSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNAQLITGMSFH 307
             + +++ L GLE+WT+ N+  V ++   ++  +  W+ + +  +  HD + L T +   
Sbjct: 237 DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLR 295

Query: 308 GTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC-CSASAA 366
           G + G+     MC+ ++S  +    ++     +  +AH +GHN GM HD   C CS    
Sbjct: 296 GLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPR- 353

Query: 367 DGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLED 426
              CIM    G+P    F+ C+  +   Y       CL     T+ ++  +RCGNG +E+
Sbjct: 354 ---CIMHE--GNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEE 407

Query: 427 GEECDCGEEEEC-NNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPE 485
           GEECDCG  + C  +PCC  SNCTL  G+ CA G CC  CK L  G +CR++  +CDLPE
Sbjct: 408 GEECDCGPLKHCAKDPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPE 466

Query: 486 FCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVN 545
           +C G S  CP +FY  DG PC+  + YCY   C    EQC++++G GA  A + C++++N
Sbjct: 467 WCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELN 525

Query: 546 VAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQC 605
             GD  G+CG   N  + KCN+ D +CG+IQC++    P  S+   +          I C
Sbjct: 526 TLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA---RFNDIMC 581

Query: 606 RGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCN 665
             T  + G +      D G V  GT+CG +HIC    C + +   +      CN  G+CN
Sbjct: 582 WSTDYHLGMKGP----DIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICN 637

Query: 666 NNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCR 725
           N  +CHC   W PP C   G+GGS+DSGP P          + + +L++  ++L   CC 
Sbjct: 638 NKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL---CC- 693

Query: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRK 785
               L +L   + P K +Q                      +QTP  K +     +I R+
Sbjct: 694 ----LYRLCKKSKPIKKQQD---------------------VQTPSAKEE----EKIQRR 724

Query: 786 PSQPPPRPPPDYLRGGSPP--APLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPA 843
           P + PP+  P  +   S P   P  +H       S  P   +  ++S  R  PS+  PP 
Sbjct: 725 PHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPP---VTPSQSQPRVMPSQSQPPV 781

Query: 844 PNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRP 884
              + SQ   +  P Q   P  P   +  L       P+ P
Sbjct: 782 ---MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTP 819


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  361 bits (926), Expect = 2e-99
 Identities = 244/821 (29%), Positives = 386/821 (47%), Gaps = 70/821 (8%)

Query: 73  GRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTC 132
           G++ I+ ++  + LF+       YT  G        ++++C+YHG V     S V+LSTC
Sbjct: 60  GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119

Query: 133 -RGIRGLITVSSNLSYVIEPLPDSKG-QHLIYR--SEHLKPPPGNCGFEHSKPTTRDWAL 188
             G +G++ ++ + +Y I+PL  S   +HL+Y+  SE  +      GF  ++ T R    
Sbjct: 120 FGGFQGILQIN-DFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFE 178

Query: 189 QFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248
           +    T+K+   +        + VE+ +V D   + +  R+       L  I N VD   
Sbjct: 179 EIDNSTQKQSSYVGW--WIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL 236

Query: 249 RSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNAQLITGMSFH 307
             + +++ L GLE+WT+ N+  V ++   ++  +  W+ + +  +  HD + L T +   
Sbjct: 237 DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLR 295

Query: 308 GTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC-CSASAA 366
           G + G+     MC+ ++S  +    ++     +  +AH +GHN GM HD   C CS    
Sbjct: 296 GLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPR- 353

Query: 367 DGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLED 426
              CIM    G+P    F+ C+  +   Y       CL     T+ ++  +RCGNG +E+
Sbjct: 354 ---CIMHE--GNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEE 407

Query: 427 GEECDCGEEEEC-NNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPE 485
           GEECDCG  + C  +PCC  SNCTL  G+ CA G CC  CK L  G +CR++  +CDLPE
Sbjct: 408 GEECDCGPLKHCAKDPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPE 466

Query: 486 FCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVN 545
           +C G S  CP +FY  DG PC+  + YCY   C    EQC++++G GA  A + C++++N
Sbjct: 467 WCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELN 525

Query: 546 VAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQC 605
             GD  G+CG   N  + KCN+ D +CG+IQC++    P  S+   +          I C
Sbjct: 526 TLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA---RFNDIMC 581

Query: 606 RGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCN 665
             T  + G +      D G V  GT+CG +HIC    C + +   +      CN  G+CN
Sbjct: 582 WSTDYHLGMKGP----DIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICN 637

Query: 666 NNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCR 725
           N  +CHC   W PP C   G+GGS+DSGP P          + + +L++  ++L   CC 
Sbjct: 638 NKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL---CC- 693

Query: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRK 785
               L +L   + P K +Q                      +QTP  K +     +I R+
Sbjct: 694 ----LYRLCKKSKPIKKQQD---------------------VQTPSAKEE----EKIQRR 724

Query: 786 PSQPPPRPPPDYLRGGSPP--APLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPA 843
           P + PP+  P  +   S P   P  +H       S  P   +  ++S  R  PS+  PP 
Sbjct: 725 PHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPP---VTPSQSQPRVMPSQSQPPV 781

Query: 844 PNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRP 884
              + SQ   +  P Q   P  P   +  L       P+ P
Sbjct: 782 ---MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTP 819


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  361 bits (926), Expect = 2e-99
 Identities = 244/821 (29%), Positives = 386/821 (47%), Gaps = 70/821 (8%)

Query: 73  GRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTC 132
           G++ I+ ++  + LF+       YT  G        ++++C+YHG V     S V+LSTC
Sbjct: 60  GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119

Query: 133 -RGIRGLITVSSNLSYVIEPLPDSKG-QHLIYR--SEHLKPPPGNCGFEHSKPTTRDWAL 188
             G +G++ ++ + +Y I+PL  S   +HL+Y+  SE  +      GF  ++ T R    
Sbjct: 120 FGGFQGILQIN-DFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFE 178

Query: 189 QFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248
           +    T+K+   +        + VE+ +V D   + +  R+       L  I N VD   
Sbjct: 179 EIDNSTQKQSSYVGW--WIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL 236

Query: 249 RSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNAQLITGMSFH 307
             + +++ L GLE+WT+ N+  V ++   ++  +  W+ + +  +  HD + L T +   
Sbjct: 237 DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLR 295

Query: 308 GTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADC-CSASAA 366
           G + G+     MC+ ++S  +    ++     +  +AH +GHN GM HD   C CS    
Sbjct: 296 GLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPR- 353

Query: 367 DGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLED 426
              CIM    G+P    F+ C+  +   Y       CL     T+ ++  +RCGNG +E+
Sbjct: 354 ---CIMHE--GNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEE 407

Query: 427 GEECDCGEEEEC-NNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPE 485
           GEECDCG  + C  +PCC  SNCTL  G+ CA G CC  CK L  G +CR++  +CDLPE
Sbjct: 408 GEECDCGPLKHCAKDPCC-LSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPE 466

Query: 486 FCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVN 545
           +C G S  CP +FY  DG PC+  + YCY   C    EQC++++G GA  A + C++++N
Sbjct: 467 WCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELN 525

Query: 546 VAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQC 605
             GD  G+CG   N  + KCN+ D +CG+IQC++    P  S+   +          I C
Sbjct: 526 TLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWA---RFNDIMC 581

Query: 606 RGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCN 665
             T  + G +      D G V  GT+CG +HIC    C + +   +      CN  G+CN
Sbjct: 582 WSTDYHLGMKGP----DIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICN 637

Query: 666 NNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCR 725
           N  +CHC   W PP C   G+GGS+DSGP P          + + +L++  ++L   CC 
Sbjct: 638 NKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL---CC- 693

Query: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRK 785
               L +L   + P K +Q                      +QTP  K +     +I R+
Sbjct: 694 ----LYRLCKKSKPIKKQQD---------------------VQTPSAKEE----EKIQRR 724

Query: 786 PSQPPPRPPPDYLRGGSPP--APLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPA 843
           P + PP+  P  +   S P   P  +H       S  P   +  ++S  R  PS+  PP 
Sbjct: 725 PHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPP---VTPSQSQPRVMPSQSQPPV 781

Query: 844 PNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRP 884
              + SQ   +  P Q   P  P   +  L       P+ P
Sbjct: 782 ---MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPPVTP 819


>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
           sapiens]
          Length = 769

 Score =  358 bits (920), Expect = 1e-98
 Identities = 251/752 (33%), Positives = 347/752 (46%), Gaps = 66/752 (8%)

Query: 3   GGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQH-ELIIPQWKTSESPVREKH 61
           G AGA R   L     P  P         R S  G  + Q  +  + Q      PV   H
Sbjct: 26  GPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV---H 82

Query: 62  PLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRE 121
             +    + A      LDLE N  L +  Y E H++  G  Q +T    DHC+Y G +R 
Sbjct: 83  LAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGA-GDHCYYQGKLRG 141

Query: 122 TELSSVTLSTCRGIRGLITVSSNLSYVIEP--------LPDSKGQHLIYRSEHLKPPPG- 172
              S   LSTC+G+ G+ +   NL+Y++EP         P     HLIYR+  L  P G 
Sbjct: 142 NPHSFAALSTCQGLHGVFS-DGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGC 200

Query: 173 ---NCGFE---HSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKN 226
               C F     S P  R        + K++ RR      +  KYVEL ++ D+  F++ 
Sbjct: 201 REPGCLFAVPAQSAPPNRP-----RLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQM 255

Query: 227 RRDQDATKHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSW 285
           R+    T +    + N  D  Y+  LN RI LV +E W  G+  +V ++   TL   + +
Sbjct: 256 RQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVY 315

Query: 286 RRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAH 345
           RR+ L +   D   L +G +F  T+ G A +  +CS+   GGVN     N   +A T+A 
Sbjct: 316 RREGLPEP-SDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVN--EYGNMGAMAVTLAQ 372

Query: 346 EMGHNFGMT----HDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGG 401
            +G N GM       SA  C       GCIM   TG   P+ F+ C+  E +++LQ GGG
Sbjct: 373 TLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMED-TGFYLPRKFSRCSIDEYNQFLQEGGG 431

Query: 402 MCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNP---CCNASNCTLRPGAECAH 458
            CL N P    L     CGNG++E GEECDCG  +EC+     CC    CTL   A C+ 
Sbjct: 432 SCLFNKP--LKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCK--KCTLTHDAMCSD 487

Query: 459 GSCCHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMC 518
           G CC +CK    G  CRE   +CD+ E CTG S  CP N +++DG  C+  Q  CY G C
Sbjct: 488 GLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRC 547

Query: 519 LTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQ 578
            T   QCQ LWG  A  A   C+EK+NV G   G+CG+  +G   +C+ +D  CG + C 
Sbjct: 548 KTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLCGFLLCV 604

Query: 579 SSEARPLESNAVP--IDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNH 636
           +    P   + V      T    G+++ CRG HV     +  D  D   V  GT CG N 
Sbjct: 605 NISGAPRLGDLVGDISSVTFYHQGKELDCRGGHV-----QLADGSDLSYVEDGTACGPNM 659

Query: 637 ICFEGQCRNTSFFETEGC---GKK--CNGHGVCNNNQNCHCLPGWAPPFCN------TPG 685
           +C + +C   S F    C   G++  C+ HGVC+N   C C P W    C+      T  
Sbjct: 660 LCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSP 719

Query: 686 HGGSIDSGPMPPES---VGPVVAGVLVAILVL 714
             G  +    P  +   +G +   VLVA +VL
Sbjct: 720 PTGETERYKGPSGTNIIIGSIAGAVLVAAIVL 751


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score =  353 bits (906), Expect = 4e-97
 Identities = 232/693 (33%), Positives = 344/693 (49%), Gaps = 55/693 (7%)

Query: 109 LEDH------CFYHGTVRETELSSVTLSTCRG-IRGLITVSSNLSYVIEPLPDSKG-QHL 160
           LEDH      C Y G+V+E+  S  T+STC G +RG+  + +   Y IEPL  S   +H+
Sbjct: 100 LEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAK-HYQIEPLKASPSFEHV 158

Query: 161 IYRSEHLKPPPGN--CGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVA 218
           +Y  +  K   GN  CG    +    +W  Q      K   R         KY+EL L+ 
Sbjct: 159 VYLLK--KEQFGNQVCGLSDDEI---EW--QMAPYENKARLRDFPGSYKHPKYLELILLF 211

Query: 219 DYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYS- 277
           D   ++    +     H  I +   +D +++ + +RI L  LEVWT  N   V     + 
Sbjct: 212 DQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAE 271

Query: 278 TLWSFLSWRRKLL-AQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENA 336
            L  F+ +++ +L A+   D A L     ++           +CS+  +G V+     N 
Sbjct: 272 VLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAW--SFGKVCSLEYAGSVSTLLDTNI 329

Query: 337 IGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAA-TGHPFPKVFNGCNRRELDRY 395
           +  A   AHE+GH  GM+HD   C      +  CIM +  TG      F+ C+     ++
Sbjct: 330 LAPATWSAHELGHAVGMSHDEQYCQCRGRLN--CIMGSGRTG------FSNCSYISFFKH 381

Query: 396 LQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAE 455
           + SG   CL+N+P   + Y  +RCGN  +ED EECDCG  EEC    C  SNC L+PGA 
Sbjct: 382 ISSGA-TCLNNIPG--LGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGAN 438

Query: 456 CAHGSCCHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYN 515
           C+ G CCH C+    G +CR++  +CDL E+C G S  CP + Y+ DGTPC+  +  C+ 
Sbjct: 439 CSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFR 497

Query: 516 GMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKI 575
             C +   QCQ ++GP A  AP  C++ VN+ GD FGNC        +KC   ++ CG++
Sbjct: 498 KGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRL 557

Query: 576 QCQSSEARPLESNAVPIDTTII---MNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKC 632
           QC + E  P     +P  TTII   +    + C GT  +   +  G + D G++  GT C
Sbjct: 558 QCINVETIP----DLPEHTTIISTHLQAENLMCWGTGYHLSMKPMG-IPDLGMINDGTSC 612

Query: 633 GYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDS 692
           G   +CF+  C N+S  + +   +KCN  GVCNN +NCHC+ GWAPPFC   G+GGSIDS
Sbjct: 613 GEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDS 672

Query: 693 GP------MPPESVGPVVAGVLVAILVLAVLMLMYYCCRQ----NNKLGQLKPSALPSKL 742
           GP        P S+   V  +++  L+L +L +++   RQ    + K  Q K     +K 
Sbjct: 673 GPPGLLRGAIPSSIW--VVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKT 730

Query: 743 RQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRK 775
            Q+ S    V + S T       + +T Q + K
Sbjct: 731 EQEESKTKTVQEESKTKTGQEESEAKTGQEESK 763


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  353 bits (905), Expect = 5e-97
 Identities = 221/669 (33%), Positives = 327/669 (48%), Gaps = 51/669 (7%)

Query: 73  GRELILDLEKNEQLFAP-----SYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSV 127
           G+  I+ +  N+ LFA      +YTE H      P      ++D C+YHG V     S V
Sbjct: 119 GQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPF-----IQDDCYYHGYVEGVPESLV 173

Query: 128 TLSTCRG-IRGLITVSSNLSYVIEPLPDSKG-QHLIYR--SEHLKPPPGNCGFEHSKPTT 183
            LSTC G   G++ ++ +L Y I+P+  S   +HL+Y+  S+  + PP  CG    K   
Sbjct: 174 ALSTCSGGFLGMLQIN-DLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEK-IA 231

Query: 184 RDWALQFTQQTKKRPRRMKREDL----NSMKYVELYLVADYLEFQKNRRDQDATKHKLIE 239
               LQ +         +K+          ++VEL +V D + +  ++ +    +H++  
Sbjct: 232 HQMELQLSYNFT-----LKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFN 286

Query: 240 IANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNA 298
           + N VD FY  L + + L G+++WT  N    S +  + L  F  W+   L  +  HD A
Sbjct: 287 VVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVA 346

Query: 299 QLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSA 358
            L       G  +G+A +  +C    + GV++      +  A T+ HE+GHN GM HD+ 
Sbjct: 347 HLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQ 405

Query: 359 DC-CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQS--GGGMCLSNMPDTRMLYG 415
            C C        CIM     H + KV    +     +Y  S    G+C+   P    ++ 
Sbjct: 406 WCVCELQ----WCIM-----HAYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFR 456

Query: 416 GRRCGNGYLEDGEECDCGEEEEC-NNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLC 474
            + CGN  +E+GEECDCG   +C  +PCC   NCTL PGA CA G CC  CK L  GTLC
Sbjct: 457 LKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAFGICCKDCKFLPSGTLC 515

Query: 475 REQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGAR 534
           R+Q  +CDLPE+C G S  CP + Y  DG  C    A+CY   C  +  QC++++G  AR
Sbjct: 516 RQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDAR 574

Query: 535 PAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDT 594
            A   C++++N  G+ FG+CG  +   + KC   D  CG++QC++    P   N +   T
Sbjct: 575 SASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIP---NLIEHST 630

Query: 595 TIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGC 654
               +     C GT  + G      + D G V  GT CG   IC   +C +         
Sbjct: 631 VQQFHLNDTTCWGTDYHLGMA----IPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQ 686

Query: 655 GKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESV-GPVVAGVLVAILV 713
            K CN  G+CNN Q+CHC   WAPP+C   G+GGS DSGP P  ++ G  V G L  + +
Sbjct: 687 PKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSL 746

Query: 714 LAVLMLMYY 722
           L +L L+ +
Sbjct: 747 LCLLPLVAF 755


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score =  339 bits (870), Expect = 6e-93
 Identities = 201/619 (32%), Positives = 312/619 (50%), Gaps = 31/619 (5%)

Query: 109 LEDHCFYHGTVRETELSSVTLSTC-RGIRGLITVSSNLSYVIEPLPDSKG-QHLIYR--S 164
           + D C+YHG V     S V  S C  G RG++ +S  L+Y IEP+  S   +HL+Y+  S
Sbjct: 105 IPDDCYYHGYVEGAPESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNS 163

Query: 165 EHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQ 224
              + P   CG    +   +    +  + +   P+       ++  ++EL +V ++  F 
Sbjct: 164 NETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAW-FLELVVVVNHDFFI 222

Query: 225 KNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLS 284
            ++ +    +  +  + N VD  Y+ L   I L+G+E+W  GN+  ++      L  F  
Sbjct: 223 YSQSNISKVQEDVFLVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIE-QVLNDFSQ 281

Query: 285 WRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMA 344
           W++  L+Q  HD A +    S   + +GLA +  +C      GV+    +     A T+A
Sbjct: 282 WKQISLSQLQHDAAHMFIKNSLI-SILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVA 340

Query: 345 HEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCL 404
           HE+GH  GM HD   C      + GCIM   T     + F  C+  +  +   + G  CL
Sbjct: 341 HELGHTLGMQHDEEFCF---CGERGCIMN--TFRVPAEKFTNCSYADFMKTTLNQGS-CL 394

Query: 405 SNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQ 464
            N P    ++  +RCGNG +E  E+CDCG  ++C    C   NCTLRPGA CA G CC  
Sbjct: 395 HNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKD 454

Query: 465 CKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQ 524
           CK +  G LCR++  +CDLPE+C G S  CP + Y  DG PC    AYCY   C  + + 
Sbjct: 455 CKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPC-SDSAYCYQKRCNNHDQH 513

Query: 525 CQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNG-EHRKCNMRDAKCGKIQCQSSEAR 583
           C++++G  A+ A   C++++N  G+ FG+CG  +NG  + KC++ D  CG++QC++    
Sbjct: 514 CREIFGKDAKSASQNCYKEINSQGNRFGHCG--INGTTYLKCHISDVFCGRVQCENVRDI 571

Query: 584 PLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQC 643
           PL  +   +  T I NG  + C G   +       ++ D G V  GT CG   IC   +C
Sbjct: 572 PLLQDHFTLQHTHI-NG--VTCWGIDYHL----RMNISDIGEVKDGTVCGPGKICIHKKC 624

Query: 644 RNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPV 703
            + S        + CN  G+CNN  +CHC  GW+PP+C   G+GGSIDSGP   +     
Sbjct: 625 VSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAK----- 679

Query: 704 VAGVLVAILVLAVLMLMYY 722
             GV + ++V+  L ++ +
Sbjct: 680 -RGVFLPLIVIPSLSVLTF 697


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,768,031
Number of Sequences: 37866
Number of extensions: 2857876
Number of successful extensions: 22979
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 194
Number of HSP's successfully gapped in prelim test: 1280
Number of HSP's that attempted gapping in prelim test: 14188
Number of HSP's gapped (non-prelim): 6353
length of query: 918
length of database: 18,247,518
effective HSP length: 111
effective length of query: 807
effective length of database: 14,044,392
effective search space: 11333824344
effective search space used: 11333824344
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.