Search of human proteins with 148664238

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
         (787 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s...  1622   0.0  
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro...   613   e-175
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi...   578   e-165
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   484   e-136
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   337   3e-92
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   337   3e-92
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   337   3e-92
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   337   3e-92
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...   337   3e-92
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   331   1e-90
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...   315   1e-85
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   299   6e-81
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   297   2e-80
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   295   1e-79
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   281   1e-75
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   281   2e-75
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   273   6e-73
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   264   2e-70
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   258   2e-68
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   256   7e-68
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   254   3e-67
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   254   3e-67
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   254   3e-67
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   254   3e-67
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...   254   3e-67
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   254   3e-67
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   253   6e-67
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   252   1e-66
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   252   1e-66
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   251   2e-66

>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
           sapiens]
          Length = 787

 Score = 1622 bits (4200), Expect = 0.0
 Identities = 787/787 (100%), Positives = 787/787 (100%)

Query: 1   MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY 60
           MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY
Sbjct: 1   MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY 60

Query: 61  TVHLKQRYFLADNFMIYLYNQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGI 120
           TVHLKQRYFLADNFMIYLYNQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGI
Sbjct: 61  TVHLKQRYFLADNFMIYLYNQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGI 120

Query: 121 LQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPAV 180
           LQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPAV
Sbjct: 121 LQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPAV 180

Query: 181 PDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWS 240
           PDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWS
Sbjct: 181 PDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWS 240

Query: 241 DENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYS 300
           DENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYS
Sbjct: 241 DENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYS 300

Query: 301 AGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNGVKTFS 360
           AGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNGVKTFS
Sbjct: 301 AGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNGVKTFS 360

Query: 361 SCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCD 420
           SCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCD
Sbjct: 361 SCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCD 420

Query: 421 FRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLING 480
           FRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLING
Sbjct: 421 FRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLING 480

Query: 481 LSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYV 540
           LSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYV
Sbjct: 481 LSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYV 540

Query: 541 FCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGS 600
           FCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGS
Sbjct: 541 FCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGS 600

Query: 601 QCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGF 660
           QCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGF
Sbjct: 601 QCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGF 660

Query: 661 SIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSS 720
           SIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSS
Sbjct: 661 SIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSS 720

Query: 721 ESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDST 780
           ESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDST
Sbjct: 721 ESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDST 780

Query: 781 QTQSSSN 787
           QTQSSSN
Sbjct: 781 QTQSSSN 787


>gi|7656861 a disintegrin and metalloprotease domain 18
           preproprotein [Homo sapiens]
          Length = 739

 Score =  613 bits (1582), Expect = e-175
 Identities = 308/728 (42%), Positives = 453/728 (62%), Gaps = 32/728 (4%)

Query: 1   MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY 60
           MF L  LL  L G L +  G +   L + +P KI++N    SE+   ++ YII ID + Y
Sbjct: 1   MFLLLALLTEL-GRLQAHEGSEGIFLHVTVPRKIKSN---DSEVSERKMIYIITIDGQPY 56

Query: 61  TVHLKQRYFLADNFMIYLYNQ-GSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRG 119
           T+HL ++ FL  NF++Y YN+ GS+++ S      C+YQG    +P+S VTLS CSGLRG
Sbjct: 57  TLHLGKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRG 116

Query: 120 ILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIF-IDRS---LKEQPMDDNIFISEK 175
            LQFEN+SYGIEP+ES+  F+H++Y++KN D +++I  ++ S    K+QP    +    K
Sbjct: 117 FLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIK 176

Query: 176 SEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSS 235
           +   +  L P YLE++I+V+K LYDY GS+ M VT K+++++GL N+MFTQFK+T++LSS
Sbjct: 177 N---LSKLLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSS 233

Query: 236 LELWSDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMC 295
           LELWS+EN+IST G+AD++LQ+FL WK+ YL LRPHDIAYLL+Y  +P+Y+GA FPGT+C
Sbjct: 234 LELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVC 293

Query: 296 ITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNG 355
              Y AG+A+YP  I LE F+VI+ Q+L L++G++YDD  +C C  +TCIMN E V ++G
Sbjct: 294 NKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASG 353

Query: 356 VKTFSSCSLRSFQNFISNVGVKCLQNKPQMQK-KSPKPVCGNGRLEGNEICDCGTEAQCG 414
            K FS+CS+  ++ F+S    KCLQ    +Q     +PVCGNG LE NE CDCG + +C 
Sbjct: 354 RKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQ 413

Query: 415 PASCCDFRTCVLKDGAKCYKGLCC-KDCQILQSGVECRPKAHPECDIAENCNGSSPECGP 473
              CCD+ TC LK   KC  G CC   C++  +G  CR    PECD  E CNG+S  C P
Sbjct: 414 FKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVP 473

Query: 474 DITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGR 533
           D   +NG  CK     CY+G C   D +C  +FGKG++ APFAC++E+ S  +R  NCG 
Sbjct: 474 DTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCG- 532

Query: 534 DRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITV--DYKLPRTVP 591
            +N++ + C  ++++CG+L C  P +     +    +Y++++D VC+++     +     
Sbjct: 533 FKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGT 592

Query: 592 DPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPP 651
           D   V +G+ C     CVN+ C +  ++  + +  + +C G G+C++   C C PG++PP
Sbjct: 593 DNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCN-ATTKCKGKGICNNFGNCQCFPGHRPP 651

Query: 652 NC--QIRSKGFSIFPEEDMGSIMERASGKTE-------NTW-LLGFLIALPILIVTTAIV 701
           +C  Q  S G SI    D G+  +     TE       N W +L F I LP  IV T ++
Sbjct: 652 DCKFQFGSPGGSI----DDGNFQKSGDFYTEKGYNTHWNNWFILSFCIFLPFFIVFTTVI 707

Query: 702 LARKQLKK 709
             R ++ K
Sbjct: 708 FKRNEISK 715


>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
           sapiens]
          Length = 735

 Score =  578 bits (1490), Expect = e-165
 Identities = 309/750 (41%), Positives = 443/750 (59%), Gaps = 39/750 (5%)

Query: 1   MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY 60
           M+R+  LL+GL GL      F +  +QI +PEKI++   +  E    Q SY I I+ K Y
Sbjct: 1   MWRVLFLLSGLGGLRMDS-NFDSLPVQITVPEKIRSIIKEGIE---SQASYKIVIEGKPY 56

Query: 61  TVHLKQRYFLADNFMIYLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRG 119
           TV+L Q+ FL  NF +Y Y+  G M     D Q  C+YQG IEGYP S+V +STC+GLRG
Sbjct: 57  TVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRG 116

Query: 120 ILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPA 179
           +LQFENVSYGIEPLES+V F+HV+Y++K++  D++++ ++ ++ + +    F  +  EP 
Sbjct: 117 VLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLS---FKLQSVEPQ 173

Query: 180 VPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELW 239
               F  Y+EMH++V+K LY++ GSD+ +V  KV +++GL N++F  F +TI+LSSLELW
Sbjct: 174 QD--FAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELW 231

Query: 240 SDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRY 299
            DENKI+T GEA+ELL  FL WK SYL LRPHD+A+LL+Y +   Y+GA F G MC   Y
Sbjct: 232 IDENKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANY 291

Query: 300 SAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNGVKTF 359
           + GV L+P+ I+LE+ AVI+ Q+L+LS+GI+YDD  KCQCS + CIMNPE +  +GVK F
Sbjct: 292 AGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIF 351

Query: 360 SSCSLRSFQNFISNVGVKCLQNKPQMQK-KSPKPVCGNGRLEGNEICDCGTEAQCG--PA 416
           S+CS   F +FIS    +CL N+P++      + VCGN +LE  E CDCGTE  C     
Sbjct: 352 SNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGE 411

Query: 417 SCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDIT 476
           +CCD  TC  K G+ C +G CC++C  +     CRP +  ECD+ E CNGSS  C  +  
Sbjct: 412 TCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRP-SFEECDLPEYCNGSSASCPENHY 470

Query: 477 LINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRN 536
           +  G  C  N++IC DG C   D +C   FGK     P  CY  + S++D  GNCG   +
Sbjct: 471 VQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGIS-D 529

Query: 537 NKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAV 596
           + Y  C   NL CG+L+C Y  +         +IYA +   +CI V++         + +
Sbjct: 530 SGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWI 589

Query: 597 KNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIR 656
           K+G+ C   +VC N+ CV S  +       + +C+  GVC+++  CHCS  Y PP+C ++
Sbjct: 590 KDGTSCGSNKVCRNQRCVSSSYL--GYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQ 647

Query: 657 S---KGFSI----FPEEDMGS------IMERASGKTENTWLLGFLIALPILIV----TTA 699
           S    G SI    FP   + +       +E         W   F + +P  I+       
Sbjct: 648 SDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRW--PFFLFIPFFIIFCVLIAI 705

Query: 700 IVLARKQLKKWFAKE---EEFPSSESKSEG 726
           +V    Q KKW  ++   +E P SES+ +G
Sbjct: 706 MVKVNFQRKKWRTEDYSSDEQPESESEPKG 735


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  484 bits (1245), Expect = e-136
 Identities = 269/762 (35%), Positives = 416/762 (54%), Gaps = 39/762 (5%)

Query: 5   WLLLAGLCG--LLASRPGFQN----SLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEK 58
           WLLL GL G  L A+RPGFQ     S  +I+ P ++     ++     +Q+SY+I  + K
Sbjct: 16  WLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGK 75

Query: 59  LYTVHLKQ-RYFLADNFMIYLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSG 116
            + +HL++ +  L ++F++Y YN +G++ T   +IQ  C+Y+G +EG  +S + LS C G
Sbjct: 76  EHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFG 135

Query: 117 LRGILQFENVSYGIEPLESAVEFQHVLYKLKN----------EDNDIAIFIDRSLKEQPM 166
           LRG+L  EN SYGIEPL+++  F+H++Y++ +           + DI     +  +E+P 
Sbjct: 136 LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPP 195

Query: 167 DDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQ 226
                +  +    +P     Y+E+ IVVDK  YD  G +   V  ++I +    +SM+  
Sbjct: 196 SMTQLLRRR-RAVLPQT--RYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIM 252

Query: 227 FKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYL-NLRPHDIAYLLIYMDYPRY 285
             + IVL  LE+W++ N I+ VG A ++L  F++W++ +L   R HD A L++   +   
Sbjct: 253 LNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGT 312

Query: 286 LGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCI 345
            G  F GT+C   ++ G+ ++  +IT+E FA IV   L  +LG+++DD + C C   +CI
Sbjct: 313 AGMAFVGTVCSRSHAGGINVFG-QITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCI 371

Query: 346 MNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEIC 405
           MN     ++G + FSSCS   F+    N G  CL N P+  +    P CGN  ++  E C
Sbjct: 372 MNSG---ASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEEC 428

Query: 406 DCGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCN 465
           DCGT  +C    CC+  TC LK  A+C  G CCKDC+ L  G  CR K   ECD+ E CN
Sbjct: 429 DCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTS-ECDVPEYCN 487

Query: 466 GSSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQS 525
           GSS  C PD+ + NG  C+NNK  CY+G C   DA+C+ +FG  ++ AP  C+ E+ S+ 
Sbjct: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547

Query: 526 DRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYK 585
           DRFGNCG    N+Y  C   N +CG+L C      P       +I    R + C  VD++
Sbjct: 548 DRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQ 606

Query: 586 LPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCS 645
           L   VPDP  V  G++C  G++C N +CV++ ++     V  ++C GHGVC+S   CHC 
Sbjct: 607 LGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDV-QKKCHGHGVCNSNKNCHCE 665

Query: 646 PGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARK 705
            G+ PPNC+ +  G S+    D G      +    +  L+ F + +P+++    I + R 
Sbjct: 666 NGWAPPNCETKGYGGSV----DSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRD 721

Query: 706 QL-KKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYAS 746
           QL + +F K+    S   +S+G  Q  A+ S   GS   + S
Sbjct: 722 QLWRSYFRKKR---SQTYESDGKNQ--ANPSRQPGSVPRHVS 758


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  337 bits (864), Expect = 3e-92
 Identities = 224/755 (29%), Positives = 380/755 (50%), Gaps = 47/755 (6%)

Query: 28  IVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHLKQRYFLADNFM-IYLY-NQGSMN 85
           +VIP +I   T   +   +  +SYI+P   + + +H+K +  L    + ++ Y +QG++ 
Sbjct: 33  VVIPVRITGTTRGMTPPGW--LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAIL 90

Query: 86  TYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRGILQFENVSYGIEPLESAVEFQHVLY 144
                +Q  CYY G +EG P+S+V+LSTC  G +GILQ  + +Y I+PL  +  F+H++Y
Sbjct: 91  EDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVY 150

Query: 145 KLKNEDNDIAI----FIDRSLKEQPMDDNIFISEKSEPAVPDLFPLY--LEMHIVVDKTL 198
           K+ +E+   +     F+   +  +   + I  S + + +    +  +  +E+ +V+D  L
Sbjct: 151 KMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYL 210

Query: 199 Y-DYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQK 257
           Y  Y  +DS ++ +  + IV + +S+     V ++L  LE+W+++N I  V +  + +  
Sbjct: 211 YIRYERNDSKLLEDLYV-IVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHL 268

Query: 258 FLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFA 316
           + +WK   +  R  HD ++L   +      G      MC    S  +  +  + TL  F+
Sbjct: 269 YCKWKSENITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNK-TLGTFS 327

Query: 317 VIVTQMLALSLGISYDDPKKCQCSESTCIM---NPEVVQSNGVKTFSSCSLRSFQNFISN 373
           + V   L  +LG+++D+   C+CS+  CIM   NP + +      FS+CS   F  +   
Sbjct: 328 IAVAHHLGHNLGMNHDEDT-CRCSQPRCIMHEGNPPITK------FSNCSYGDFWEYTVE 380

Query: 374 VGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCY 433
              KCL      +       CGNG +E  E CDCG    C    CC    C L DG+ C 
Sbjct: 381 -RTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCC-LSNCTLTDGSTCA 438

Query: 434 KGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDG 493
            GLCCKDC+ L SG  CR + + ECD+ E CNG+S +C  D  + +G+ CK   + CY+ 
Sbjct: 439 FGLCCKDCKFLPSGKVCRKEVN-ECDLPEWCNGTSHKCPDDFYVEDGIPCKERGY-CYEK 496

Query: 494 DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLV 553
            CHD + +C  +FG G+  A   CY+E+ +  DR G+CG  +N  Y+ C   ++ CGR+ 
Sbjct: 497 SCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGI-KNATYIKCNISDVQCGRIQ 555

Query: 554 CTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNREC 613
           C   T  P   ++  V +A   D +C + DY L    PD   VK+G++C I  +C++R C
Sbjct: 556 CENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHC 615

Query: 614 VESRIIKASAHVCSQQ-CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIM 672
           V   I+ ++   CS   C+  G+C++++ CHC+  + PPNC I+  G S+    D G   
Sbjct: 616 VHITILNSN---CSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV----DSGPPP 668

Query: 673 ERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYA 732
           +R   K +  +L   L+ +  +++     L +K   K   K+++  +  +K E   Q   
Sbjct: 669 KRKK-KKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIKKQQDVQTPSAKEEEKIQRRP 725

Query: 733 SQSSSEGSTQTYASQ-----TRSESSSQADTSKSK 762
            +   +       SQ     T S+S  Q   S+S+
Sbjct: 726 HELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQ 760


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  337 bits (864), Expect = 3e-92
 Identities = 224/755 (29%), Positives = 380/755 (50%), Gaps = 47/755 (6%)

Query: 28  IVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHLKQRYFLADNFM-IYLY-NQGSMN 85
           +VIP +I   T   +   +  +SYI+P   + + +H+K +  L    + ++ Y +QG++ 
Sbjct: 33  VVIPVRITGTTRGMTPPGW--LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAIL 90

Query: 86  TYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRGILQFENVSYGIEPLESAVEFQHVLY 144
                +Q  CYY G +EG P+S+V+LSTC  G +GILQ  + +Y I+PL  +  F+H++Y
Sbjct: 91  EDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVY 150

Query: 145 KLKNEDNDIAI----FIDRSLKEQPMDDNIFISEKSEPAVPDLFPLY--LEMHIVVDKTL 198
           K+ +E+   +     F+   +  +   + I  S + + +    +  +  +E+ +V+D  L
Sbjct: 151 KMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYL 210

Query: 199 Y-DYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQK 257
           Y  Y  +DS ++ +  + IV + +S+     V ++L  LE+W+++N I  V +  + +  
Sbjct: 211 YIRYERNDSKLLEDLYV-IVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHL 268

Query: 258 FLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFA 316
           + +WK   +  R  HD ++L   +      G      MC    S  +  +  + TL  F+
Sbjct: 269 YCKWKSENITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNK-TLGTFS 327

Query: 317 VIVTQMLALSLGISYDDPKKCQCSESTCIM---NPEVVQSNGVKTFSSCSLRSFQNFISN 373
           + V   L  +LG+++D+   C+CS+  CIM   NP + +      FS+CS   F  +   
Sbjct: 328 IAVAHHLGHNLGMNHDEDT-CRCSQPRCIMHEGNPPITK------FSNCSYGDFWEYTVE 380

Query: 374 VGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCY 433
              KCL      +       CGNG +E  E CDCG    C    CC    C L DG+ C 
Sbjct: 381 -RTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCC-LSNCTLTDGSTCA 438

Query: 434 KGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDG 493
            GLCCKDC+ L SG  CR + + ECD+ E CNG+S +C  D  + +G+ CK   + CY+ 
Sbjct: 439 FGLCCKDCKFLPSGKVCRKEVN-ECDLPEWCNGTSHKCPDDFYVEDGIPCKERGY-CYEK 496

Query: 494 DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLV 553
            CHD + +C  +FG G+  A   CY+E+ +  DR G+CG  +N  Y+ C   ++ CGR+ 
Sbjct: 497 SCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGI-KNATYIKCNISDVQCGRIQ 555

Query: 554 CTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNREC 613
           C   T  P   ++  V +A   D +C + DY L    PD   VK+G++C I  +C++R C
Sbjct: 556 CENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHC 615

Query: 614 VESRIIKASAHVCSQQ-CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIM 672
           V   I+ ++   CS   C+  G+C++++ CHC+  + PPNC I+  G S+    D G   
Sbjct: 616 VHITILNSN---CSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV----DSGPPP 668

Query: 673 ERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYA 732
           +R   K +  +L   L+ +  +++     L +K   K   K+++  +  +K E   Q   
Sbjct: 669 KRKK-KKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIKKQQDVQTPSAKEEEKIQRRP 725

Query: 733 SQSSSEGSTQTYASQ-----TRSESSSQADTSKSK 762
            +   +       SQ     T S+S  Q   S+S+
Sbjct: 726 HELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQ 760


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  337 bits (864), Expect = 3e-92
 Identities = 224/755 (29%), Positives = 380/755 (50%), Gaps = 47/755 (6%)

Query: 28  IVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHLKQRYFLADNFM-IYLY-NQGSMN 85
           +VIP +I   T   +   +  +SYI+P   + + +H+K +  L    + ++ Y +QG++ 
Sbjct: 33  VVIPVRITGTTRGMTPPGW--LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAIL 90

Query: 86  TYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRGILQFENVSYGIEPLESAVEFQHVLY 144
                +Q  CYY G +EG P+S+V+LSTC  G +GILQ  + +Y I+PL  +  F+H++Y
Sbjct: 91  EDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVY 150

Query: 145 KLKNEDNDIAI----FIDRSLKEQPMDDNIFISEKSEPAVPDLFPLY--LEMHIVVDKTL 198
           K+ +E+   +     F+   +  +   + I  S + + +    +  +  +E+ +V+D  L
Sbjct: 151 KMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYL 210

Query: 199 Y-DYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQK 257
           Y  Y  +DS ++ +  + IV + +S+     V ++L  LE+W+++N I  V +  + +  
Sbjct: 211 YIRYERNDSKLLEDLYV-IVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHL 268

Query: 258 FLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFA 316
           + +WK   +  R  HD ++L   +      G      MC    S  +  +  + TL  F+
Sbjct: 269 YCKWKSENITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNK-TLGTFS 327

Query: 317 VIVTQMLALSLGISYDDPKKCQCSESTCIM---NPEVVQSNGVKTFSSCSLRSFQNFISN 373
           + V   L  +LG+++D+   C+CS+  CIM   NP + +      FS+CS   F  +   
Sbjct: 328 IAVAHHLGHNLGMNHDEDT-CRCSQPRCIMHEGNPPITK------FSNCSYGDFWEYTVE 380

Query: 374 VGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCY 433
              KCL      +       CGNG +E  E CDCG    C    CC    C L DG+ C 
Sbjct: 381 -RTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCC-LSNCTLTDGSTCA 438

Query: 434 KGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDG 493
            GLCCKDC+ L SG  CR + + ECD+ E CNG+S +C  D  + +G+ CK   + CY+ 
Sbjct: 439 FGLCCKDCKFLPSGKVCRKEVN-ECDLPEWCNGTSHKCPDDFYVEDGIPCKERGY-CYEK 496

Query: 494 DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLV 553
            CHD + +C  +FG G+  A   CY+E+ +  DR G+CG  +N  Y+ C   ++ CGR+ 
Sbjct: 497 SCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGI-KNATYIKCNISDVQCGRIQ 555

Query: 554 CTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNREC 613
           C   T  P   ++  V +A   D +C + DY L    PD   VK+G++C I  +C++R C
Sbjct: 556 CENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHC 615

Query: 614 VESRIIKASAHVCSQQ-CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIM 672
           V   I+ ++   CS   C+  G+C++++ CHC+  + PPNC I+  G S+    D G   
Sbjct: 616 VHITILNSN---CSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV----DSGPPP 668

Query: 673 ERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYA 732
           +R   K +  +L   L+ +  +++     L +K   K   K+++  +  +K E   Q   
Sbjct: 669 KRKK-KKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIKKQQDVQTPSAKEEEKIQRRP 725

Query: 733 SQSSSEGSTQTYASQ-----TRSESSSQADTSKSK 762
            +   +       SQ     T S+S  Q   S+S+
Sbjct: 726 HELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQ 760


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  337 bits (864), Expect = 3e-92
 Identities = 224/755 (29%), Positives = 380/755 (50%), Gaps = 47/755 (6%)

Query: 28  IVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHLKQRYFLADNFM-IYLY-NQGSMN 85
           +VIP +I   T   +   +  +SYI+P   + + +H+K +  L    + ++ Y +QG++ 
Sbjct: 33  VVIPVRITGTTRGMTPPGW--LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAIL 90

Query: 86  TYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRGILQFENVSYGIEPLESAVEFQHVLY 144
                +Q  CYY G +EG P+S+V+LSTC  G +GILQ  + +Y I+PL  +  F+H++Y
Sbjct: 91  EDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVY 150

Query: 145 KLKNEDNDIAI----FIDRSLKEQPMDDNIFISEKSEPAVPDLFPLY--LEMHIVVDKTL 198
           K+ +E+   +     F+   +  +   + I  S + + +    +  +  +E+ +V+D  L
Sbjct: 151 KMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYL 210

Query: 199 Y-DYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQK 257
           Y  Y  +DS ++ +  + IV + +S+     V ++L  LE+W+++N I  V +  + +  
Sbjct: 211 YIRYERNDSKLLEDLYV-IVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHL 268

Query: 258 FLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFA 316
           + +WK   +  R  HD ++L   +      G      MC    S  +  +  + TL  F+
Sbjct: 269 YCKWKSENITPRMQHDTSHLFTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNK-TLGTFS 327

Query: 317 VIVTQMLALSLGISYDDPKKCQCSESTCIM---NPEVVQSNGVKTFSSCSLRSFQNFISN 373
           + V   L  +LG+++D+   C+CS+  CIM   NP + +      FS+CS   F  +   
Sbjct: 328 IAVAHHLGHNLGMNHDEDT-CRCSQPRCIMHEGNPPITK------FSNCSYGDFWEYTVE 380

Query: 374 VGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCY 433
              KCL      +       CGNG +E  E CDCG    C    CC    C L DG+ C 
Sbjct: 381 -RTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCC-LSNCTLTDGSTCA 438

Query: 434 KGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDG 493
            GLCCKDC+ L SG  CR + + ECD+ E CNG+S +C  D  + +G+ CK   + CY+ 
Sbjct: 439 FGLCCKDCKFLPSGKVCRKEVN-ECDLPEWCNGTSHKCPDDFYVEDGIPCKERGY-CYEK 496

Query: 494 DCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLV 553
            CHD + +C  +FG G+  A   CY+E+ +  DR G+CG  +N  Y+ C   ++ CGR+ 
Sbjct: 497 SCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGI-KNATYIKCNISDVQCGRIQ 555

Query: 554 CTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNREC 613
           C   T  P   ++  V +A   D +C + DY L    PD   VK+G++C I  +C++R C
Sbjct: 556 CENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHC 615

Query: 614 VESRIIKASAHVCSQQ-CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIM 672
           V   I+ ++   CS   C+  G+C++++ CHC+  + PPNC I+  G S+    D G   
Sbjct: 616 VHITILNSN---CSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV----DSGPPP 668

Query: 673 ERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYA 732
           +R   K +  +L   L+ +  +++     L +K   K   K+++  +  +K E   Q   
Sbjct: 669 KRKK-KKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIKKQQDVQTPSAKEEEKIQRRP 725

Query: 733 SQSSSEGSTQTYASQ-----TRSESSSQADTSKSK 762
            +   +       SQ     T S+S  Q   S+S+
Sbjct: 726 HELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQ 760


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score =  337 bits (863), Expect = 3e-92
 Identities = 201/671 (29%), Positives = 342/671 (50%), Gaps = 28/671 (4%)

Query: 4   LWL-LLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTV 62
           LWL +   + G   + P    +  ++VIP K+ +    +    +  +SY +    + + V
Sbjct: 17  LWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGW--LSYSLRFGGQKHVV 74

Query: 63  HLKQRYFLADNFM-IYLY-NQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRG 119
           H++ +  L    + ++ Y ++ ++      I   CYY G +EG P+S+V  S C  G RG
Sbjct: 75  HMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFGGFRG 134

Query: 120 ILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIF----IDRSLKEQPMDDNIFISEK 175
           +L+   ++Y IEP+  +  F+H++YK+ + +           ++ +  Q ++     +  
Sbjct: 135 VLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEAENSA 194

Query: 176 SEPAVPD---LFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIV 232
            EP           +LE+ +VV+   + Y  S+   V   V  +V + +SM+ Q    I+
Sbjct: 195 LEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQLGTYII 254

Query: 233 LSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPG 292
           L  +E+W+  N +  +   +++L  F +WKQ  L+   HD A++ I       LG  +  
Sbjct: 255 LIGIEIWNQGN-VFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIKNSLISILGLAYVA 313

Query: 293 TMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQ 352
            +C      GV  +  + T   FA  V   L  +LG+ +D+ + C C E  CIMN   V 
Sbjct: 314 GICRPPIDCGVDNFQGD-TWSLFANTVAHELGHTLGMQHDE-EFCFCGERGCIMNTFRVP 371

Query: 353 SNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQ 412
           +   + F++CS   F     N G  CL N P++ +      CGNG +E  E CDCG+  Q
Sbjct: 372 A---EKFTNCSYADFMKTTLNQG-SCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQ 427

Query: 413 CGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECG 472
           C   +CC    C L+ GA C  GLCCKDC+ + SG  CR + + ECD+ E CNG+S +C 
Sbjct: 428 CEQDACC-LLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVN-ECDLPEWCNGTSHQCP 485

Query: 473 PDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCG 532
            D  + +G+ C ++ + CY   C++ D  C  +FGK +++A   CY+EI SQ +RFG+CG
Sbjct: 486 EDRYVQDGIPCSDSAY-CYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCG 544

Query: 533 RDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPD 592
            +    Y+ C   ++ CGR+ C      P  Q++  + +  +    C  +DY L   + D
Sbjct: 545 IN-GTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLRMNISD 603

Query: 593 PLAVKNGSQCDIGRVCVNRECVESRIIKASAHVC-SQQCSGHGVCDSRNKCHCSPGYKPP 651
              VK+G+ C  G++C++++CV   ++   +HVC  + C+  G+C++++ CHC  G+ PP
Sbjct: 604 IGEVKDGTVCGPGKICIHKKCVSLSVL---SHVCLPETCNMKGICNNKHHCHCGYGWSPP 660

Query: 652 NCQIRSKGFSI 662
            CQ R  G SI
Sbjct: 661 YCQHRGYGGSI 671


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  331 bits (849), Expect = 1e-90
 Identities = 217/729 (29%), Positives = 370/729 (50%), Gaps = 37/729 (5%)

Query: 4   LWL-LLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTV 62
           LW  +   + G   +RP    +  ++VIP K+ +    +    +  +SY +    + Y V
Sbjct: 67  LWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGW--LSYSLRFGGQRYIV 124

Query: 63  HLK-QRYFLADNFMIYLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCS-GLRG 119
           H++  +   A +  ++ Y  Q ++      IQ  CYY G +EG P+S+V LSTCS G  G
Sbjct: 125 HMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLG 184

Query: 120 ILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPMDDNI-------FI 172
           +LQ  ++ Y I+P+  +  F+H++YK+ ++D      +   L E+ +   +       F 
Sbjct: 185 MLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPP-MRCGLTEEKIAHQMELQLSYNFT 243

Query: 173 SEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIV 232
            ++S          ++E+ +VVD   Y +  S++  V ++V  +V + +S +   +V ++
Sbjct: 244 LKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVI 303

Query: 233 LSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFP 291
           L+ +++W+  N + T G+ D +L+ F  WK   LN R  HD+A+L I       LG  + 
Sbjct: 304 LTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGVAYV 363

Query: 292 GTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVV 351
             +C   ++ GV ++ ++  L  FA+ +   L  +LG+ + D + C C    CIM+    
Sbjct: 364 KGICQNPFNTGVDVF-EDNRLVVFAITLGHELGHNLGMQH-DTQWCVCELQWCIMH---A 418

Query: 352 QSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEA 411
                  FS+CS   + +   + G+ C+Q  P          CGN  +E  E CDCGT  
Sbjct: 419 YRKVTTKFSNCSYAQYWDSTISSGL-CIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIR 477

Query: 412 QCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPEC 471
           QC    CC    C L  GA C  G+CCKDC+ L SG  CR +   ECD+ E CNG+S +C
Sbjct: 478 QCAKDPCC-LLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQV-GECDLPEWCNGTSHQC 535

Query: 472 GPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNC 531
             D+ + +G+SC  N F CY+  C++ D +C+ +FG+ +R+A  +CY+EI +Q +RFG+C
Sbjct: 536 PDDVYVQDGISCNVNAF-CYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHC 594

Query: 532 GRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVP 591
           G      YV C   +++CGR+ C      P   E+  V    + D+ C   DY L   +P
Sbjct: 595 G-IVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIP 653

Query: 592 DPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPP 651
           D   VK+G+ C   ++C+ ++C  + ++  S     + C+  G+C+++  CHC+  + PP
Sbjct: 654 DIGEVKDGTVCGPEKICIRKKC--ASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPP 711

Query: 652 NCQIRSKGFSIF----PEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQL 707
            C+ +  G S      P+ +M  +     GK     LL  L+ L   ++    VL +K+ 
Sbjct: 712 YCKDKGYGGSADSGPPPKNNMEGL--NVMGKLRYLSLL-CLLPLVAFLLFCLHVLFKKRT 768

Query: 708 KKWFAKEEE 716
           K   +KE+E
Sbjct: 769 K---SKEDE 774


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score =  315 bits (806), Expect = 1e-85
 Identities = 228/772 (29%), Positives = 379/772 (49%), Gaps = 51/772 (6%)

Query: 27  QIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHL-KQRYFLADNFMIYLYNQ-GSM 84
           ++ IPEK+         +    +SY++ +  K + +HL  +R  L  +  ++ + + G +
Sbjct: 42  EVTIPEKLSFRGEVQGVVS--PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGEL 99

Query: 85  NTYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRGILQFENVSYGIEPLESAVEFQHVL 143
                 I   C Y G+++   DS  T+STC  GLRG+   +   Y IEPL+++  F+HV+
Sbjct: 100 LEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVV 159

Query: 144 YKLKNED--NDIAIFIDRSLKEQ--PMDDNIFISEKSEPAVPDLF--PLYLEMHIVVDKT 197
           Y LK E   N +    D  ++ Q  P ++   + +      P  +  P YLE+ ++ D++
Sbjct: 160 YLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRD-----FPGSYKHPKYLELILLFDQS 214

Query: 198 LYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKIST-VGEADELLQ 256
            Y +  ++   V +  I + G+ ++ F   ++ I L +LE+W+D NKI     E  E+L 
Sbjct: 215 RYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLG 274

Query: 257 KFLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAF 315
           +F+ +K+S LN R   D A+L +   Y   L   F G +C   Y+  V+    +  + A 
Sbjct: 275 RFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSF-GKVCSLEYAGSVSTL-LDTNILAP 332

Query: 316 AVIVTQMLALSLGISYDDPKKCQC-SESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNV 374
           A      L  ++G+S+D+ + CQC     CIM       +G   FS+CS  SF   IS+ 
Sbjct: 333 ATWSAHELGHAVGMSHDE-QYCQCRGRLNCIMG------SGRTGFSNCSYISFFKHISS- 384

Query: 375 GVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYK 434
           G  CL N P +     +  CGN  +E NE CDCG+  +C    CC    C L+ GA C  
Sbjct: 385 GATCLNNIPGLGYVLKR--CGNKIVEDNEECDCGSTEECQKDRCCQ-SNCKLQPGANCSI 441

Query: 435 GLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGD 494
           GLCC DC+   SG  CR + + ECD+AE C+G+S  C  D+   +G  CK     C+   
Sbjct: 442 GLCCHDCRFRPSGYVCRQEGN-ECDLAEYCDGNSSSCPNDVYKQDGTPCKYEGR-CFRKG 499

Query: 495 CHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVC 554
           C     +C+S+FG  +  AP  CY+ +    D+FGNC       +  C   N ICGRL C
Sbjct: 500 CRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQC 559

Query: 555 TYPTRKPFHQENGDVIYAFVR--DSVCITVDYKL---PRTVPDPLAVKNGSQCDIGRVCV 609
                 P   E+  +I   ++  + +C    Y L   P  +PD   + +G+ C  GRVC 
Sbjct: 560 INVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCF 619

Query: 610 NRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMG 669
            + CV S +++       ++C+  GVC++R  CHC  G+ PP C+    G SI    D G
Sbjct: 620 KKNCVNSSVLQFDC--LPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSI----DSG 673

Query: 670 SIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQL--KKWFAKEEEFPSSESKS--- 724
                      + W++  ++   IL++ + + +  +Q+       K+E+ P S++K+   
Sbjct: 674 PPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKTEQE 733

Query: 725 EGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKS 776
           E  T+T   +S ++   +   ++T  E  S+A T + +S+ + E+   ++KS
Sbjct: 734 ESKTKTVQEESKTKTGQEESEAKTGQE-ESKAKTGQEESKANIESKRPKAKS 784


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  299 bits (766), Expect = 6e-81
 Identities = 203/655 (30%), Positives = 304/655 (46%), Gaps = 81/655 (12%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIA 154
           CYY G++ GY DS V+LSTCSGLRG++ FEN SY +EP++SA              N   
Sbjct: 119 CYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSAT-------------NRYK 165

Query: 155 IFIDRSLKEQPMDDNIFISEKSEP--AVPDLFP------------------LYLEMHIVV 194
           +F  + LK          S  + P  A  ++FP                   Y+E+ IV 
Sbjct: 166 LFPAKKLKSVRGSCG---SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVA 222

Query: 195 DKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADEL 254
           D   +   G D   V  ++IEI    +  +    + IVL  +E+W+D +K S   +    
Sbjct: 223 DNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTS 282

Query: 255 LQKFLEW-KQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGT---------MCITRYSAGVA 304
           L +FL+W K   L  + HD A L+         G  F GT         MC    S G+ 
Sbjct: 283 LHEFLDWRKMKLLPRKSHDNAQLVS--------GVYFQGTTIGMAPIMSMCTADQSGGIV 334

Query: 305 LYPKEITLEAFAVIVTQMLALSLGISYDD-PKKCQCSEST----CIMNPEVVQSNGVKTF 359
           +   +  L A AV +   L  + G+++D   + C C  +     CIMN        +  F
Sbjct: 335 MDHSDNPLGA-AVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPM-VF 392

Query: 360 SSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCC 419
           SSCS +  +  +      CL N P++++      CGN  +E  E CDCG   +C    CC
Sbjct: 393 SSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEEC-MNRCC 451

Query: 420 DFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLIN 479
           +  TC LK  A C  GLCC+DCQ+  +G  CR  ++  CD+ E C G+SP C  ++ L +
Sbjct: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSN-SCDLPEFCTGASPHCPANVYLHD 510

Query: 480 GLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKY 539
           G SC++    CY+G C   + +C +++G G++ AP  C+E + S  D +GNCG+   + +
Sbjct: 511 GHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSF 570

Query: 540 VFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFV-----RDSVCITVDYKLPRTVPDPL 594
             C  R+  CG++ C     +P    N   I   +        +C      L   +PDP 
Sbjct: 571 AKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPG 630

Query: 595 AVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQ 654
            V  G++C  G++C+NR+C    I     H C+ QC G GVC++R  CHC   + PP C 
Sbjct: 631 LVLAGTKCADGKICLNRQC--QNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCD 688

Query: 655 IRSKGFSIFPEEDMGSIMERASGKTENTWL-LGFLIALPILIVTTAIV-LARKQL 707
                F      D G I +      +N  L +G L+ +  L+    +V L RK L
Sbjct: 689 ----KFGFGGSTDSGPIRQ-----ADNQGLTIGILVTILCLLAAGFVVYLKRKTL 734


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  297 bits (761), Expect = 2e-80
 Identities = 189/599 (31%), Positives = 283/599 (47%), Gaps = 70/599 (11%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIA 154
           CYY G++ GY DS V+LSTCSGLRG++ FEN SY +EP++SA              N   
Sbjct: 119 CYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSAT-------------NRYK 165

Query: 155 IFIDRSLKEQPMDDNIFISEKSEP--AVPDLFP------------------LYLEMHIVV 194
           +F  + LK          S  + P  A  ++FP                   Y+E+ IV 
Sbjct: 166 LFPAKKLKSVRGSCG---SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVA 222

Query: 195 DKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADEL 254
           D   +   G D   V  ++IEI    +  +    + IVL  +E+W+D +K S   +    
Sbjct: 223 DNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTS 282

Query: 255 LQKFLEW-KQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGT---------MCITRYSAGVA 304
           L +FL+W K   L  + HD A L+         G  F GT         MC    S G+ 
Sbjct: 283 LHEFLDWRKMKLLPRKSHDNAQLVS--------GVYFQGTTIGMAPIMSMCTADQSGGIV 334

Query: 305 LYPKEITLEAFAVIVTQMLALSLGISYDD-PKKCQCSEST----CIMNPEVVQSNGVKTF 359
           +   +  L A AV +   L  + G+++D   + C C  +     CIMN        +  F
Sbjct: 335 MDHSDNPLGA-AVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPM-VF 392

Query: 360 SSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCC 419
           SSCS +  +  +      CL N P++++      CGN  +E  E CDCG   +C    CC
Sbjct: 393 SSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEEC-MNRCC 451

Query: 420 DFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLIN 479
           +  TC LK  A C  GLCC+DCQ+  +G  CR  ++  CD+ E C G+SP C  ++ L +
Sbjct: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSN-SCDLPEFCTGASPHCPANVYLHD 510

Query: 480 GLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKY 539
           G SC++    CY+G C   + +C +++G G++ AP  C+E + S  D +GNCG+   + +
Sbjct: 511 GHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSF 570

Query: 540 VFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFV-----RDSVCITVDYKLPRTVPDPL 594
             C  R+  CG++ C     +P    N   I   +        +C      L   +PDP 
Sbjct: 571 AKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPG 630

Query: 595 AVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNC 653
            V  G++C  G++C+NR+C    I     H C+ QC G GVC++R  CHC   + PP C
Sbjct: 631 LVLAGTKCADGKICLNRQC--QNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFC 687


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  295 bits (754), Expect = 1e-79
 Identities = 197/701 (28%), Positives = 313/701 (44%), Gaps = 61/701 (8%)

Query: 80  NQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGILQF-ENVSYGIEPLESAVE 138
           + G+  T +  ++  C+Y G +     S VTLSTC G+RG++    N+SY IEPL  + +
Sbjct: 98  SSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDS-K 156

Query: 139 FQHVLYK---------------LKNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDL 183
            QH++Y+                K    D A+   +  K++P         K E    DL
Sbjct: 157 GQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR------RMKRE----DL 206

Query: 184 FPL-YLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDE 242
             + Y+E+++V D   +     D     +K+IEI    +  +    + I L  LE+W+  
Sbjct: 207 NSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHG 266

Query: 243 NKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDY-PRYLGAVFPGTMCITRYSA 301
           N           L  FL W++  L  + HD A L+  M +    +G      MC    S 
Sbjct: 267 NMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSG 326

Query: 302 GVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCS--ESTCIMNPEVVQSNGVKTF 359
           GV +   E  +   A +  +M   + G+++D    C  S  +  CIM          K F
Sbjct: 327 GVNMDHSENAIGVAATMAHEM-GHNFGMTHDSADCCSASAADGGCIM-AAATGHPFPKVF 384

Query: 360 SSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCC 419
           + C+ R    ++ + G  CL N P  +       CGNG LE  E CDCG E +C    CC
Sbjct: 385 NGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECN-NPCC 443

Query: 420 DFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLIN 479
           +   C L+ GA+C  G CC  C++L  G  CR +A  +CD+ E C G SP C  +   ++
Sbjct: 444 NASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQAR-QCDLPEFCTGKSPHCPTNFYQMD 502

Query: 480 GLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKY 539
           G  C+  +  CY+G C     +C+ ++G G+R AP  C+E++    D FGNCG+D N ++
Sbjct: 503 GTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEH 562

Query: 540 VFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCI----TVDYKLPR---TVPD 592
             C  R+  CG++ C     +P       +    + +   I    T  Y+ P     + D
Sbjct: 563 RKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLD 622

Query: 593 PLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPN 652
           P  V  G++C    +C   +C  +   +     C ++C+GHGVC++   CHC PG+ PP 
Sbjct: 623 PGLVMTGTKCGYNHICFEGQCRNTSFFETEG--CGKKCNGHGVCNNNQNCHCLPGWAPPF 680

Query: 653 CQIRSKGFSI----FPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQLK 708
           C     G SI     P E +G +            + G L+A+ +L V   +    +Q  
Sbjct: 681 CNTPGHGGSIDSGPMPPESVGPV------------VAGVLVAILVLAVLMLMYYCCRQNN 728

Query: 709 KWFAKEEEFPSSESKSEGSTQTYASQSSSEG-STQTYASQT 748
           K    +     S+ + + S     SQ+S  G +  T+  QT
Sbjct: 729 KLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQT 769


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  281 bits (720), Expect = 1e-75
 Identities = 211/735 (28%), Positives = 337/735 (45%), Gaps = 61/735 (8%)

Query: 6   LLLAGLCGLLASRPGFQNSLLQIVIPEKIQT-NTNDSSEIEYEQ-----ISYIIPIDEKL 59
           LLL+     +   PG +    ++V P ++   +  ++ E E ++     + Y + I+ K+
Sbjct: 10  LLLSVAVSAIKELPGVKK--YEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKI 67

Query: 60  YTVHLKQ-RYFLADNFMIYLYNQ-GSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGL 117
             ++LK+ +  LA  +    YN  G   T S  I   CYYQG+I     S  ++STC GL
Sbjct: 68  AVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGL 127

Query: 118 RGILQFENVSYGIEPLESAVEF--QHVLYKLKNEDN--DIAIFIDRSLKEQPMDDNIFIS 173
           RG     +  Y IEPL        +H L+K   ++   D    +D  L    +  NI + 
Sbjct: 128 RGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALP 187

Query: 174 EKSEPAVPDL----FPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKV 229
                 + D        Y+E ++V+D   +  +  +   +  +V E+    N ++ +   
Sbjct: 188 ATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNT 247

Query: 230 TIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRP-HDIAYLLIYMDYP-RYLG 287
            + L  +E+W+D++KI     A   L+ F +W+ S L+ R  HDIA L+   +     +G
Sbjct: 248 HVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVG 307

Query: 288 AVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMN 347
             F  TMC + YS GV     +  L     +  +M   + G+ +DD   C+C  + C+M+
Sbjct: 308 LAFMSTMC-SPYSVGVVQDHSDNLLRVAGTMAHEM-GHNFGMFHDD-YSCKCPSTICVMD 364

Query: 348 PEVVQSNGVKT-FSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICD 406
             +  S  + T FSSCS  S+  F  +    CL N P        P+CGN  +E  E CD
Sbjct: 365 KAL--SFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCD 422

Query: 407 CGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNG 466
           CGT  +C    CCD +TC +K   +C  G CC+ CQ  ++G+ CRP A  ECD+ E CNG
Sbjct: 423 CGTSEECTNI-CCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRP-AKDECDLPEMCNG 480

Query: 467 SSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSD 526
            S  C  D   +NG  C + K  C  G C  L  +C  ++G G+  A  +CY   +  S 
Sbjct: 481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGS- 539

Query: 527 RFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKL 586
           ++G C R  ++  + C   + +CG+L C   +      +N       V    C T D   
Sbjct: 540 KYGYC-RRVDDTLIPCKANDTMCGKLFCQGGS------DNLPWKGRIVTFLTCKTFD--- 589

Query: 587 PRTVPDPLA-VKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCS 645
           P      +  V NG++C   +VC+N ECV+      S + CS +C GH VCD   +C C 
Sbjct: 590 PEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTN-CSSKCKGHAVCDHELQCQCE 648

Query: 646 PGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARK 705
            G+ PP+C   S  F                     + ++G L  + ++ V  A+V+ R 
Sbjct: 649 EGWIPPDCDDSSVVFHF-------------------SIVVGVLFPMAVIFVVVAMVI-RH 688

Query: 706 QLKKWFAKEEEFPSS 720
           Q  +   K+++ P S
Sbjct: 689 QSSREKQKKDQRPLS 703


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  281 bits (718), Expect = 2e-75
 Identities = 185/626 (29%), Positives = 290/626 (46%), Gaps = 50/626 (7%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFE-NVSYGIEPL--ESAVEFQ-HVLYKL---- 146
           C+YQG + G+PDS V L TCSG+ G++    N SY + P     + +F  H ++++    
Sbjct: 114 CHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLL 173

Query: 147 --------KNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTL 198
                   ++  N   +    SL   P       + ++          YLE++IV D TL
Sbjct: 174 TWKGTCGHRDPGNKAGM---TSLPGGPQSRGRREARRTRK--------YLELYIVADHTL 222

Query: 199 YDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKF 258
           +     +      +++E+    + +     + + L+ LE+W++ ++     +A+  L  F
Sbjct: 223 FLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAF 282

Query: 259 LEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGT-MCITRYSAGVALYPKEITLEAFAV 317
           L+W++     RPHD A LL    +      + P   MC    S GV+    E+ + A A 
Sbjct: 283 LQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAAT 342

Query: 318 IVTQMLALSLGISYDDPKKC--QCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVG 375
           +  + +  SLG+S+D    C    +ES   +          + FS+CS R  + F    G
Sbjct: 343 MAHE-IGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGG 401

Query: 376 VKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYKG 435
             CL N P      P  +CGNG +E  E CDCG   +C    CC    C L+ GA+C  G
Sbjct: 402 GACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDL-CCFAHNCSLRPGAQCAHG 460

Query: 436 LCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGDC 495
            CC  C +  +G  CR +A  +CD+ E C G+S  C PD+ L++G  C      C+DG C
Sbjct: 461 DCCVRCLLKPAGALCR-QAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGAC 519

Query: 496 HDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCT 555
             L+ +C+ ++G GS  AP AC++ + S  D  GNCG+D    ++ C  R+ +CG+L C 
Sbjct: 520 PTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ 579

Query: 556 --YPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLA---VKNGSQCDIGRVCVN 610
              P+    H    D         V       LP    D L    V+ G+QC    VC +
Sbjct: 580 GGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQS 639

Query: 611 RECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGS 670
           R C ++   +     C   C  HGVC+S + CHC+PG+ PP C     G S+    D G 
Sbjct: 640 RRCRKNAFQELQR--CLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSM----DSGP 693

Query: 671 IMERASGKTENTWLLGFLIA--LPIL 694
           +      +  +T+LL  L++  LP+L
Sbjct: 694 V----QAENHDTFLLAMLLSVLLPLL 715


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  273 bits (697), Expect = 6e-73
 Identities = 185/651 (28%), Positives = 305/651 (46%), Gaps = 40/651 (6%)

Query: 27  QIVIPEKI---------QTNTNDSSEIEYEQISYIIPIDEKLYTVHL-KQRYFLADNFMI 76
           Q+V P+K+          T+ +D  +   E++ Y I ++ K   +HL + R FL  N+  
Sbjct: 28  QLVRPKKLPLIQKRDTGHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSE 87

Query: 77  YLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLES 135
             Y+ +G   T    I   C+YQG+I    DS  ++STC+GLRG  +  +  Y IEP++ 
Sbjct: 88  TFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKY 147

Query: 136 AVEFQHVLYKLKNE----DNDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFPLYLEMH 191
           + E +H+++K         N     ++ + K  P D+    SE+           Y+E+ 
Sbjct: 148 SDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVPGDNE---SEEDSKIKGIHDEKYVELF 204

Query: 192 IVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEA 251
           IV D T+Y   G     + N++  +V   N ++    + + L  +E+W+ E+KI      
Sbjct: 205 IVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNI 264

Query: 252 DELLQKFLEWKQSYLNLRPHDIAYLLIYMD---YPRYLGAVFPGTMCITRYSAGVALYPK 308
           +  L +F  W++  L  R  D  ++++      Y    G  +PG MC+  YS  +    K
Sbjct: 265 ETTLLRFSFWQEKILKTRK-DFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSII---K 320

Query: 309 EITLEAFAVI--VTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNGVKTFSSCSLRS 366
           ++  +   +   +   L  +LG+ +D+   C C    C+M+ +   S     FS CS   
Sbjct: 321 DLLPDTNIIANRMAHQLGHNLGMQHDE-FPCTCPSGKCVMDSD--GSIPALKFSKCSQNQ 377

Query: 367 FQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVL 426
           +  ++ +    C+ N P          CGN +L+  E CDCG   +C    CCD  TCVL
Sbjct: 378 YHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQEC-TNPCCDAHTCVL 436

Query: 427 KDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNN 486
           K G  C +G CC+ CQI ++G  CRP A  ECD  E C G SP C  D   +NG  CKN+
Sbjct: 437 KPGFTCAEGECCESCQIKKAGSICRP-AKDECDFPEMCTGHSPACPKDQFRVNGFPCKNS 495

Query: 487 KFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRN 546
           +  C+ G C   + +C  +F   +  +   CY ++ ++ ++FG C +++ N+++ C  ++
Sbjct: 496 EGYCFMGKCPTREDQCSELFDDEAIESHDICY-KMNTKGNKFGYC-KNKENRFLPCEEKD 553

Query: 547 LICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYK---LPRTVPDPLAVKNGSQCD 603
           + CG++ CT         E  D  Y         TV  K   L     D   V +G++C 
Sbjct: 554 VRCGKIYCTGGELSSLLGE--DKTYHLKDPQKNATVKCKTIFLYHDSTDIGLVASGTKCG 611

Query: 604 IGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQ 654
            G VC N EC+    +  S + C  QC+ + V     +CHC  G  P  C+
Sbjct: 612 EGMVCNNGECLNMEKVYISTN-CPSQCNENPVDGHGLQCHCEEGQAPVACE 661


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  264 bits (675), Expect = 2e-70
 Identities = 212/760 (27%), Positives = 347/760 (45%), Gaps = 75/760 (9%)

Query: 4   LWLLLAGLCGLLA-SRPGFQNSLLQIVIP-----EKIQTNTNDSSEIEYEQISYIIPIDE 57
           LWLL A +   +A SRP       ++V+P      +++        +  E++SY++    
Sbjct: 6   LWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATG 65

Query: 58  KLYTVHL-KQRYFLADNFM-IYLYNQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCS 115
             +T+HL K R  L   +   Y    GS  T     Q  C+YQG++EGYPDS  +LSTC+
Sbjct: 66  HNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCA 125

Query: 116 GLRGILQFENVSYGIEPLESAVE-FQHVLYKLKN--EDNDIAIFIDRSLKE--QPMDDNI 170
           GLRG  Q  +  + IEPL+   E  +H +Y+ ++  +        D SL     P    +
Sbjct: 126 GLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAV 185

Query: 171 FISEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVT 230
           F     + ++P     Y+E+++VVD   +   GS++  V ++V+E+V   + ++ +    
Sbjct: 186 FRPRPGD-SLPSRETRYVELYVVVDNAEFQMLGSEA-AVRHRVLEVVNHVDKLYQKLNFR 243

Query: 231 IVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRP-HDIAYLLIYMDYP-RYLGA 288
           +VL  LE+W+ +++     +    L+  L W+      R  HD   L+  +D+    +G 
Sbjct: 244 VVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGF 303

Query: 289 VFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDD-PKKCQCSE----ST 343
                MC   +S+G             A  +   +  +LG+ +D+  + C+C E      
Sbjct: 304 ARVSAMC--SHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGR 361

Query: 344 CIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNE 403
           CIM    + S+  + FS CS    ++F+      CL N P +      PVCGN  +E  E
Sbjct: 362 CIMAGS-IGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGE 420

Query: 404 ICDCGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAEN 463
            CDCG    C    CC+  TC L +GA+C  G CC++C++  +G  CRPK    CD+ E 
Sbjct: 421 QCDCGPPEDC-RNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPK-KDMCDLEEF 478

Query: 464 CNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQS 523
           C+G  PEC  D    NG  C      CY+G C  L  +C++ +G G + A  +C+     
Sbjct: 479 CDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAEESCF----- 531

Query: 524 QSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVD 583
             D    C   R        +R  +CG L C     K   Q  G         ++CI VD
Sbjct: 532 SYDILPGCKASR--------YRADMCGVLQC-----KGGQQPLG--------RAICI-VD 569

Query: 584 YKLPRTVPDPLA---VKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRN 640
                T  D  A   V  G++C   +VC    C +  + ++S   CS QC  HGVC+ + 
Sbjct: 570 VCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSN--CSAQCHNHGVCNHKQ 627

Query: 641 KCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTA- 699
           +CHC  G+ PP+C              + + +  ASG     +++  L+ L +++VT A 
Sbjct: 628 ECHCHAGWAPPHC------------AKLLTEVHAASGSLP-VFVVVVLVLLAVVLVTLAG 674

Query: 700 IVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEG 739
           I++ RK   +  ++     ++  +S       AS+  ++G
Sbjct: 675 IIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKG 714


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  258 bits (658), Expect = 2e-68
 Identities = 209/731 (28%), Positives = 337/731 (46%), Gaps = 86/731 (11%)

Query: 27  QIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY-TVHLKQRYFLADNF-----MIYLYN 80
           +I +P ++    N  SE  Y  +       +K    VHL Q  F  + F     +  + N
Sbjct: 110 EITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILN 169

Query: 81  QGSMNTYSSDIQTQ------------CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSY 128
            G +++   +I  +            CYY G+I G  DS V LSTC+GL G+ + +   Y
Sbjct: 170 NGLLSSDYVEIHYENGKPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVY 229

Query: 129 GIEPL-----ESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPM---DDNIFISE-----K 175
            IEPL     E +    H++ K       +A    + +K   M   D   F+SE     +
Sbjct: 230 MIEPLELVHDEKSTGRPHIIQK------TLAGQYSKQMKNLTMERGDQWPFLSELQWLKR 283

Query: 176 SEPAVPDLFPL-----YLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMF-TQFKV 229
            + AV     +     YLE+ IV D   Y    S      N    +V L +S++  Q   
Sbjct: 284 RKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNT 343

Query: 230 TIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRPH-DIAYLL--IYMDYPRYL 286
            +VL ++E W+++++I       ++L +F +++Q    ++ H D  +L+  +   Y R  
Sbjct: 344 RVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQ---RIKQHADAVHLISRVTFHYKRSS 400

Query: 287 GAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPK---KCQCSES- 342
            + F G    TR   GV  Y   +   A A +++Q LA +LGI ++      KC C+ES 
Sbjct: 401 LSYFGGVCSRTR-GVGVNEYGLPM---AVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESW 456

Query: 343 -TCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEG 401
             CIM    V  +  + FS CS+  +++F+   G  CL N+P   K      CGNG +E 
Sbjct: 457 GGCIMEETGVSHS--RKFSKCSILEYRDFLQRGGGACLFNRP--TKLFEPTECGNGYVEA 512

Query: 402 NEICDCGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKD--CQILQSGVECRPKAHPECD 459
            E CDCG   +C    C   + C L +GA C  G CC +  C     G ECR   + ECD
Sbjct: 513 GEECDCGFHVECYGLCC---KKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVN-ECD 568

Query: 460 IAENCNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYE 519
           I E C G S +C P++   +G +C  N+  CY+G+C   D +C+ ++G  +  +   CYE
Sbjct: 569 ITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYE 628

Query: 520 EIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKP-FHQENGDVI----YAFV 574
           ++ ++    GNCG+D  ++++ C   ++ CG L+CT  TR P   Q  G++I    Y   
Sbjct: 629 KLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQG 687

Query: 575 RDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQ---CS 631
           R   C      L     D   V++G+ C    +C++R+C++ + +  S+     +   CS
Sbjct: 688 RVIDCSGAHVVLDDDT-DVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCS 746

Query: 632 GHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIAL 691
           GHGVC +   C C   +   +C IR    ++ P +D G       G +    ++G +   
Sbjct: 747 GHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEG-----PKGPSATNLIIGSIAG- 800

Query: 692 PILIVTTAIVL 702
              I+  AIVL
Sbjct: 801 --AILVAAIVL 809


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  256 bits (653), Expect = 7e-68
 Identities = 175/621 (28%), Positives = 277/621 (44%), Gaps = 66/621 (10%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFE-NVSYGIEPL--ESAVEFQ-HVLYKL---- 146
           C+YQG + G+PDS V L TCSG+ G++    N SY + P     + +F  H ++++    
Sbjct: 114 CHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLL 173

Query: 147 --------KNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTL 198
                   ++  N   +    SL   P       + ++          YLE++IV D TL
Sbjct: 174 TWKGTCGHRDPGNKAGM---TSLPGGPQSRGRREARRTRK--------YLELYIVADHTL 222

Query: 199 YDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKF 258
           +     +      +++E+    + +     + + L+ LE+W++ ++     +A+  L  F
Sbjct: 223 FLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAF 282

Query: 259 LEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGT-MCITRYSAGVALYPKEITLEAFAV 317
           L+W++     RPHD A LL    +      + P   MC    S GV+    E+ + A A 
Sbjct: 283 LQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAAT 342

Query: 318 IVTQMLALSLGISYDDPKKC--QCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVG 375
           +  + +  SLG+S+D    C    +ES   +          + FS+CS R  + F    G
Sbjct: 343 MAHE-IGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGG 401

Query: 376 VKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYKG 435
             CL N P      P  +CGNG +E  E CDCG   +C    CC    C L+ GA+C  G
Sbjct: 402 GACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDL-CCFAHNCSLRPGAQCAHG 460

Query: 436 LCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGDC 495
            CC  C +  +G  CR +A  +CD+ E C G+S  C PD+ L++G  C      C+DG C
Sbjct: 461 DCCVRCLLKPAGALCR-QAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGAC 519

Query: 496 HDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCT 555
             L+ +C+ ++G GS  AP AC++ + S  D  GNCG+D    ++ C  R+ +CG+L C 
Sbjct: 520 PTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQC- 578

Query: 556 YPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVE 615
               KP                         P  VP    V    Q    R  +     +
Sbjct: 579 -QGGKP---------------------SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQ 616

Query: 616 SRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERA 675
             ++         QC    VC+S + CHC+PG+ PP C     G S+    D G +    
Sbjct: 617 LDLLGLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCDKPGFGGSM----DSGPV---- 668

Query: 676 SGKTENTWLLGFLIA--LPIL 694
             +  +T+LL  L++  LP+L
Sbjct: 669 QAENHDTFLLAMLLSVLLPLL 689


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  254 bits (648), Expect = 3e-67
 Identities = 171/586 (29%), Positives = 279/586 (47%), Gaps = 29/586 (4%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFE-NVSYGIEPLESAVEFQHVLYKLKN---ED 150
           C YQG + GY  S V++ TCSGLRG++      SY +E     ++   ++ ++++     
Sbjct: 117 CCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG 176

Query: 151 NDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFP--LYLEMHIVVDKTLYDYWGSDSMI 208
           +  A+    S+  Q   ++  + ++      D+      +E+ IV D +    +  D   
Sbjct: 177 HTCALSWRESVHTQKPPEHP-LGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQH 234

Query: 209 VTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNL 268
           + N+ +E+  L ++ F    V + L  LE W+  + +         L+ FL W++++L  
Sbjct: 235 LLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLP 294

Query: 269 R-PHDIAYLLIYMDYPR-YLGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALS 326
           R PHD A L+    +    +G     ++C   +S GV +     ++   A  +   L  S
Sbjct: 295 RLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM-DHSTSILGVASSIAHELGHS 353

Query: 327 LGISYDDP-KKCQCS----ESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCL-Q 380
           LG+ +D P   C C       TCIM        G+  FS+CS R+ +  + +    CL +
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKALLDGMGSCLFE 412

Query: 381 NKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYK-GLCCK 439
             P +   +    CGN  +E  E CDCG    C    CCD  TC L+ GA+C   G CC+
Sbjct: 413 RLPSLPPMAA--FCGNMFVEPGEQCDCGFLDDCVDP-CCDSLTCQLRPGAQCASDGPCCQ 469

Query: 440 DCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLD 499
           +CQ+  SG +CRP    +CD+ E C G S +C PD++L +G  C   + +C  G C    
Sbjct: 470 NCQLRPSGWQCRP-TRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYA 528

Query: 500 ARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTR 559
            +C+S++G G++ A   C +   ++ + FG+CGR+ +  YV C  R+ ICG+L C     
Sbjct: 529 QQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRT 588

Query: 560 KPFHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVE 615
           +P      D+++  +     +  C  V   L   V  PL    G+ C  G VC++  C  
Sbjct: 589 QPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRC-- 646

Query: 616 SRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFS 661
            R+    A  C  +C GHGVCDS   C+C  G+ PP+C  + K  S
Sbjct: 647 QRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKATS 692


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  254 bits (648), Expect = 3e-67
 Identities = 171/586 (29%), Positives = 279/586 (47%), Gaps = 29/586 (4%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFE-NVSYGIEPLESAVEFQHVLYKLKN---ED 150
           C YQG + GY  S V++ TCSGLRG++      SY +E     ++   ++ ++++     
Sbjct: 117 CCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG 176

Query: 151 NDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFP--LYLEMHIVVDKTLYDYWGSDSMI 208
           +  A+    S+  Q   ++  + ++      D+      +E+ IV D +    +  D   
Sbjct: 177 HTCALSWRESVHTQKPPEHP-LGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQH 234

Query: 209 VTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNL 268
           + N+ +E+  L ++ F    V + L  LE W+  + +         L+ FL W++++L  
Sbjct: 235 LLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLP 294

Query: 269 R-PHDIAYLLIYMDYPR-YLGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALS 326
           R PHD A L+    +    +G     ++C   +S GV +     ++   A  +   L  S
Sbjct: 295 RLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM-DHSTSILGVASSIAHELGHS 353

Query: 327 LGISYDDP-KKCQCS----ESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCL-Q 380
           LG+ +D P   C C       TCIM        G+  FS+CS R+ +  + +    CL +
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKALLDGMGSCLFE 412

Query: 381 NKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYK-GLCCK 439
             P +   +    CGN  +E  E CDCG    C    CCD  TC L+ GA+C   G CC+
Sbjct: 413 RLPSLPPMAA--FCGNMFVEPGEQCDCGFLDDCVDP-CCDSLTCQLRPGAQCASDGPCCQ 469

Query: 440 DCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLD 499
           +CQ+  SG +CRP    +CD+ E C G S +C PD++L +G  C   + +C  G C    
Sbjct: 470 NCQLRPSGWQCRP-TRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYA 528

Query: 500 ARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTR 559
            +C+S++G G++ A   C +   ++ + FG+CGR+ +  YV C  R+ ICG+L C     
Sbjct: 529 QQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRT 588

Query: 560 KPFHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVE 615
           +P      D+++  +     +  C  V   L   V  PL    G+ C  G VC++  C  
Sbjct: 589 QPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRC-- 646

Query: 616 SRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFS 661
            R+    A  C  +C GHGVCDS   C+C  G+ PP+C  + K  S
Sbjct: 647 QRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKATS 692


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  254 bits (648), Expect = 3e-67
 Identities = 171/586 (29%), Positives = 279/586 (47%), Gaps = 29/586 (4%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFE-NVSYGIEPLESAVEFQHVLYKLKN---ED 150
           C YQG + GY  S V++ TCSGLRG++      SY +E     ++   ++ ++++     
Sbjct: 117 CCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG 176

Query: 151 NDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFP--LYLEMHIVVDKTLYDYWGSDSMI 208
           +  A+    S+  Q   ++  + ++      D+      +E+ IV D +    +  D   
Sbjct: 177 HTCALSWRESVHTQKPPEHP-LGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQH 234

Query: 209 VTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNL 268
           + N+ +E+  L ++ F    V + L  LE W+  + +         L+ FL W++++L  
Sbjct: 235 LLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLP 294

Query: 269 R-PHDIAYLLIYMDYPR-YLGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALS 326
           R PHD A L+    +    +G     ++C   +S GV +     ++   A  +   L  S
Sbjct: 295 RLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM-DHSTSILGVASSIAHELGHS 353

Query: 327 LGISYDDP-KKCQCS----ESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCL-Q 380
           LG+ +D P   C C       TCIM        G+  FS+CS R+ +  + +    CL +
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKALLDGMGSCLFE 412

Query: 381 NKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYK-GLCCK 439
             P +   +    CGN  +E  E CDCG    C    CCD  TC L+ GA+C   G CC+
Sbjct: 413 RLPSLPPMAA--FCGNMFVEPGEQCDCGFLDDCVDP-CCDSLTCQLRPGAQCASDGPCCQ 469

Query: 440 DCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLD 499
           +CQ+  SG +CRP    +CD+ E C G S +C PD++L +G  C   + +C  G C    
Sbjct: 470 NCQLRPSGWQCRP-TRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYA 528

Query: 500 ARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTR 559
            +C+S++G G++ A   C +   ++ + FG+CGR+ +  YV C  R+ ICG+L C     
Sbjct: 529 QQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRT 588

Query: 560 KPFHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVE 615
           +P      D+++  +     +  C  V   L   V  PL    G+ C  G VC++  C  
Sbjct: 589 QPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRC-- 646

Query: 616 SRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFS 661
            R+    A  C  +C GHGVCDS   C+C  G+ PP+C  + K  S
Sbjct: 647 QRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKATS 692


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  254 bits (648), Expect = 3e-67
 Identities = 171/586 (29%), Positives = 279/586 (47%), Gaps = 29/586 (4%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFE-NVSYGIEPLESAVEFQHVLYKLKN---ED 150
           C YQG + GY  S V++ TCSGLRG++      SY +E     ++   ++ ++++     
Sbjct: 117 CCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG 176

Query: 151 NDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFP--LYLEMHIVVDKTLYDYWGSDSMI 208
           +  A+    S+  Q   ++  + ++      D+      +E+ IV D +    +  D   
Sbjct: 177 HTCALSWRESVHTQKPPEHP-LGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQH 234

Query: 209 VTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNL 268
           + N+ +E+  L ++ F    V + L  LE W+  + +         L+ FL W++++L  
Sbjct: 235 LLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLP 294

Query: 269 R-PHDIAYLLIYMDYPR-YLGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALS 326
           R PHD A L+    +    +G     ++C   +S GV +     ++   A  +   L  S
Sbjct: 295 RLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM-DHSTSILGVASSIAHELGHS 353

Query: 327 LGISYDDP-KKCQCS----ESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCL-Q 380
           LG+ +D P   C C       TCIM        G+  FS+CS R+ +  + +    CL +
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKALLDGMGSCLFE 412

Query: 381 NKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYK-GLCCK 439
             P +   +    CGN  +E  E CDCG    C    CCD  TC L+ GA+C   G CC+
Sbjct: 413 RLPSLPPMAA--FCGNMFVEPGEQCDCGFLDDCVDP-CCDSLTCQLRPGAQCASDGPCCQ 469

Query: 440 DCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLD 499
           +CQ+  SG +CRP    +CD+ E C G S +C PD++L +G  C   + +C  G C    
Sbjct: 470 NCQLRPSGWQCRP-TRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYA 528

Query: 500 ARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTR 559
            +C+S++G G++ A   C +   ++ + FG+CGR+ +  YV C  R+ ICG+L C     
Sbjct: 529 QQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRT 588

Query: 560 KPFHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVE 615
           +P      D+++  +     +  C  V   L   V  PL    G+ C  G VC++  C  
Sbjct: 589 QPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRC-- 646

Query: 616 SRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFS 661
            R+    A  C  +C GHGVCDS   C+C  G+ PP+C  + K  S
Sbjct: 647 QRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKATS 692


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score =  254 bits (648), Expect = 3e-67
 Identities = 171/586 (29%), Positives = 279/586 (47%), Gaps = 29/586 (4%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFE-NVSYGIEPLESAVEFQHVLYKLKN---ED 150
           C YQG + GY  S V++ TCSGLRG++      SY +E     ++   ++ ++++     
Sbjct: 117 CCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG 176

Query: 151 NDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFP--LYLEMHIVVDKTLYDYWGSDSMI 208
           +  A+    S+  Q   ++  + ++      D+      +E+ IV D +    +  D   
Sbjct: 177 HTCALSWRESVHTQKPPEHP-LGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQH 234

Query: 209 VTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNL 268
           + N+ +E+  L ++ F    V + L  LE W+  + +         L+ FL W++++L  
Sbjct: 235 LLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLP 294

Query: 269 R-PHDIAYLLIYMDYPR-YLGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALS 326
           R PHD A L+    +    +G     ++C   +S GV +     ++   A  +   L  S
Sbjct: 295 RLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM-DHSTSILGVASSIAHELGHS 353

Query: 327 LGISYDDP-KKCQCS----ESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCL-Q 380
           LG+ +D P   C C       TCIM        G+  FS+CS R+ +  + +    CL +
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKALLDGMGSCLFE 412

Query: 381 NKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYK-GLCCK 439
             P +   +    CGN  +E  E CDCG    C    CCD  TC L+ GA+C   G CC+
Sbjct: 413 RLPSLPPMAA--FCGNMFVEPGEQCDCGFLDDCVDP-CCDSLTCQLRPGAQCASDGPCCQ 469

Query: 440 DCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLD 499
           +CQ+  SG +CRP    +CD+ E C G S +C PD++L +G  C   + +C  G C    
Sbjct: 470 NCQLRPSGWQCRP-TRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYA 528

Query: 500 ARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTR 559
            +C+S++G G++ A   C +   ++ + FG+CGR+ +  YV C  R+ ICG+L C     
Sbjct: 529 QQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRT 588

Query: 560 KPFHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVE 615
           +P      D+++  +     +  C  V   L   V  PL    G+ C  G VC++  C  
Sbjct: 589 QPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRC-- 646

Query: 616 SRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFS 661
            R+    A  C  +C GHGVCDS   C+C  G+ PP+C  + K  S
Sbjct: 647 QRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKATS 692


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  254 bits (648), Expect = 3e-67
 Identities = 171/586 (29%), Positives = 279/586 (47%), Gaps = 29/586 (4%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFE-NVSYGIEPLESAVEFQHVLYKLKN---ED 150
           C YQG + GY  S V++ TCSGLRG++      SY +E     ++   ++ ++++     
Sbjct: 117 CCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG 176

Query: 151 NDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFP--LYLEMHIVVDKTLYDYWGSDSMI 208
           +  A+    S+  Q   ++  + ++      D+      +E+ IV D +    +  D   
Sbjct: 177 HTCALSWRESVHTQKPPEHP-LGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQH 234

Query: 209 VTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNL 268
           + N+ +E+  L ++ F    V + L  LE W+  + +         L+ FL W++++L  
Sbjct: 235 LLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLP 294

Query: 269 R-PHDIAYLLIYMDYPR-YLGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALS 326
           R PHD A L+    +    +G     ++C   +S GV +     ++   A  +   L  S
Sbjct: 295 RLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM-DHSTSILGVASSIAHELGHS 353

Query: 327 LGISYDDP-KKCQCS----ESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCL-Q 380
           LG+ +D P   C C       TCIM        G+  FS+CS R+ +  + +    CL +
Sbjct: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKALLDGMGSCLFE 412

Query: 381 NKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYK-GLCCK 439
             P +   +    CGN  +E  E CDCG    C    CCD  TC L+ GA+C   G CC+
Sbjct: 413 RLPSLPPMAA--FCGNMFVEPGEQCDCGFLDDCVDP-CCDSLTCQLRPGAQCASDGPCCQ 469

Query: 440 DCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLD 499
           +CQ+  SG +CRP    +CD+ E C G S +C PD++L +G  C   + +C  G C    
Sbjct: 470 NCQLRPSGWQCRP-TRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYA 528

Query: 500 ARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTR 559
            +C+S++G G++ A   C +   ++ + FG+CGR+ +  YV C  R+ ICG+L C     
Sbjct: 529 QQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRT 588

Query: 560 KPFHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIGRVCVNRECVE 615
           +P      D+++  +     +  C  V   L   V  PL    G+ C  G VC++  C  
Sbjct: 589 QPLLGSIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRC-- 646

Query: 616 SRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFS 661
            R+    A  C  +C GHGVCDS   C+C  G+ PP+C  + K  S
Sbjct: 647 QRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKATS 692


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  253 bits (645), Expect = 6e-67
 Identities = 202/725 (27%), Positives = 333/725 (45%), Gaps = 63/725 (8%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQ----HVLYK----- 145
           CYYQG+I G PDS V LSTC GL G+    N +Y IEP E+    +    H +YK     
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194

Query: 146 -----LKNEDNDIAIFIDRS-LKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLY 199
                L +E   + I   +  LK +P      +  +  P   +    Y+E+ IV D  ++
Sbjct: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQL--RRYPRNVEEETKYIELMIVNDHLMF 252

Query: 200 DYWGSDSMIVTNKVIEIVGLANSMFT-QFKVTIVLSSLELWSDENKISTVGEADELLQKF 258
                  +        +V +A+ ++  Q K  IVL ++E W+ +NK +        L++F
Sbjct: 253 KKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREF 312

Query: 259 LEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFAVI 318
           +++++ ++  +   +             GA + G +C      GV  + K    +  AV 
Sbjct: 313 MKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAVT 369

Query: 319 VTQMLALSLGISYDDPK------KCQCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFIS 372
           + Q LA ++GI  D  K      KC+ + S CIM          K F+ C++  + +F++
Sbjct: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFLN 427

Query: 373 NVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQC--GPASCCDFRTCVLKDGA 430
           + G  CL NKP   K    P CGNG +E  E CDCGT A+C    A CC  + C L   +
Sbjct: 428 SGGGACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDS 483

Query: 431 KCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFIC 490
           +C  GLCCK C+    G  CR +A  +CDI E C+G+S +C P+I  ++G SC   + IC
Sbjct: 484 QCSDGLCCKKCKFQPMGTVCR-EAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGIC 542

Query: 491 YDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICG 550
           + G C   D +C+ ++G+    +   CYE++  +    GNCG+D++  ++ C  R+++CG
Sbjct: 543 FGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDT-WIQCNKRDVLCG 601

Query: 551 RLVCTYPTRKP-FHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIG 605
            L+CT     P   + +G++    V    R   C     KL   V D   V++G+ C   
Sbjct: 602 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQ 660

Query: 606 RVCVNRECVESRIIKASAHVCSQQ---CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSI 662
            +C+   C+       S  + S++   CSG+GVC +  KC C+  +   +C       + 
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN------TY 714

Query: 663 FPEEDMGSIMERASGK-TENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSE 721
           FP  D        SG     T ++  +IA  IL++  A++L    +  W  K       E
Sbjct: 715 FPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVL--ALILG---ITAWGYKNYR----E 765

Query: 722 SKSEGSTQTYASQSSSEGSTQTYASQTRSESSS-QADTSKSKSEDSAEAYTSRSKSQDST 780
            +S G + +++ +              R  S+S Q +   +K +   + +  RS S ++ 
Sbjct: 766 QRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTETL 825

Query: 781 QTQSS 785
               S
Sbjct: 826 SPAKS 830


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  252 bits (643), Expect = 1e-66
 Identities = 201/718 (27%), Positives = 331/718 (46%), Gaps = 63/718 (8%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQ----HVLYK----- 145
           CYYQG+I G PDS V LSTC GL G+    N +Y IEP E+    +    H +YK     
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194

Query: 146 -----LKNEDNDIAIFIDRS-LKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLY 199
                L +E   + I   +  LK +P      +  +  P   +    Y+E+ IV D  ++
Sbjct: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQL--RRYPRNVEEETKYIELMIVNDHLMF 252

Query: 200 DYWGSDSMIVTNKVIEIVGLANSMFT-QFKVTIVLSSLELWSDENKISTVGEADELLQKF 258
                  +        +V +A+ ++  Q K  IVL ++E W+ +NK +        L++F
Sbjct: 253 KKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREF 312

Query: 259 LEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFAVI 318
           +++++ ++  +   +             GA + G +C      GV  + K    +  AV 
Sbjct: 313 MKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAVT 369

Query: 319 VTQMLALSLGISYDDPK------KCQCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFIS 372
           + Q LA ++GI  D  K      KC+ + S CIM          K F+ C++  + +F++
Sbjct: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFLN 427

Query: 373 NVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQC--GPASCCDFRTCVLKDGA 430
           + G  CL NKP   K    P CGNG +E  E CDCGT A+C    A CC  + C L   +
Sbjct: 428 SGGGACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDS 483

Query: 431 KCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFIC 490
           +C  GLCCK C+    G  CR +A  +CDI E C+G+S +C P+I  ++G SC   + IC
Sbjct: 484 QCSDGLCCKKCKFQPMGTVCR-EAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGIC 542

Query: 491 YDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICG 550
           + G C   D +C+ ++G+    +   CYE++  +    GNCG+D++  ++ C  R+++CG
Sbjct: 543 FGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDT-WIQCNKRDVLCG 601

Query: 551 RLVCTYPTRKP-FHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIG 605
            L+CT     P   + +G++    V    R   C     KL   V D   V++G+ C   
Sbjct: 602 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQ 660

Query: 606 RVCVNRECVESRIIKASAHVCSQQ---CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSI 662
            +C+   C+       S  + S++   CSG+GVC +  KC C+  +   +C       + 
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN------TY 714

Query: 663 FPEEDMGSIMERASGK-TENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSE 721
           FP  D        SG     T ++  +IA  IL++  A++L    +  W  K       E
Sbjct: 715 FPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVL--ALILG---ITAWGYKNYR----E 765

Query: 722 SKSEGSTQTYASQSSSEGSTQTYASQTRSESSS-QADTSKSKSEDSAEAYTSRSKSQD 778
            +S G + +++ +              R  S+S Q +   +K +   + +  RS S +
Sbjct: 766 QRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTE 823


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  252 bits (643), Expect = 1e-66
 Identities = 201/718 (27%), Positives = 331/718 (46%), Gaps = 63/718 (8%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQ----HVLYK----- 145
           CYYQG+I G PDS V LSTC GL G+    N +Y IEP E+    +    H +YK     
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194

Query: 146 -----LKNEDNDIAIFIDRS-LKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLY 199
                L +E   + I   +  LK +P      +  +  P   +    Y+E+ IV D  ++
Sbjct: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQL--RRYPRNVEEETKYIELMIVNDHLMF 252

Query: 200 DYWGSDSMIVTNKVIEIVGLANSMFT-QFKVTIVLSSLELWSDENKISTVGEADELLQKF 258
                  +        +V +A+ ++  Q K  IVL ++E W+ +NK +        L++F
Sbjct: 253 KKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREF 312

Query: 259 LEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFAVI 318
           +++++ ++  +   +             GA + G +C      GV  + K    +  AV 
Sbjct: 313 MKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAVT 369

Query: 319 VTQMLALSLGISYDDPK------KCQCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFIS 372
           + Q LA ++GI  D  K      KC+ + S CIM          K F+ C++  + +F++
Sbjct: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFLN 427

Query: 373 NVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQC--GPASCCDFRTCVLKDGA 430
           + G  CL NKP   K    P CGNG +E  E CDCGT A+C    A CC  + C L   +
Sbjct: 428 SGGGACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDS 483

Query: 431 KCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFIC 490
           +C  GLCCK C+    G  CR +A  +CDI E C+G+S +C P+I  ++G SC   + IC
Sbjct: 484 QCSDGLCCKKCKFQPMGTVCR-EAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGIC 542

Query: 491 YDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICG 550
           + G C   D +C+ ++G+    +   CYE++  +    GNCG+D++  ++ C  R+++CG
Sbjct: 543 FGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDT-WIQCNKRDVLCG 601

Query: 551 RLVCTYPTRKP-FHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIG 605
            L+CT     P   + +G++    V    R   C     KL   V D   V++G+ C   
Sbjct: 602 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQ 660

Query: 606 RVCVNRECVESRIIKASAHVCSQQ---CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSI 662
            +C+   C+       S  + S++   CSG+GVC +  KC C+  +   +C       + 
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN------TY 714

Query: 663 FPEEDMGSIMERASGK-TENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSE 721
           FP  D        SG     T ++  +IA  IL++  A++L    +  W  K       E
Sbjct: 715 FPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVL--ALILG---ITAWGYKNYR----E 765

Query: 722 SKSEGSTQTYASQSSSEGSTQTYASQTRSESSS-QADTSKSKSEDSAEAYTSRSKSQD 778
            +S G + +++ +              R  S+S Q +   +K +   + +  RS S +
Sbjct: 766 QRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTE 823


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  251 bits (641), Expect = 2e-66
 Identities = 197/713 (27%), Positives = 329/713 (46%), Gaps = 67/713 (9%)

Query: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQ----HVLYK----- 145
           CYYQG+I G PDS V LSTC GL G+    N +Y IEP E+    +    H +YK     
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194

Query: 146 -----LKNEDNDIAIFIDRS-LKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLY 199
                L +E   + I   +  LK +P      +  +  P   +    Y+E+ IV D  ++
Sbjct: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQL--RRYPRNVEEETKYIELMIVNDHLMF 252

Query: 200 DYWGSDSMIVTNKVIEIVGLANSMFT-QFKVTIVLSSLELWSDENKISTVGEADELLQKF 258
                  +        +V +A+ ++  Q K  IVL ++E W+ +NK +        L++F
Sbjct: 253 KKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREF 312

Query: 259 LEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFAVI 318
           +++++ ++  +   +             GA + G +C      GV  + K    +  AV 
Sbjct: 313 MKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAVT 369

Query: 319 VTQMLALSLGISYDDPK------KCQCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFIS 372
           + Q LA ++GI  D  K      KC+ + S CIM          K F+ C++  + +F++
Sbjct: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFLN 427

Query: 373 NVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQC--GPASCCDFRTCVLKDGA 430
           + G  CL NKP   K    P CGNG +E  E CDCGT A+C    A CC  + C L   +
Sbjct: 428 SGGGACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDS 483

Query: 431 KCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFIC 490
           +C  GLCCK C+    G  CR +A  +CDI E C+G+S +C P+I  ++G SC   + IC
Sbjct: 484 QCSDGLCCKKCKFQPMGTVCR-EAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGIC 542

Query: 491 YDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICG 550
           + G C   D +C+ ++G+    +   CYE++  +    GNCG+D++  ++ C  R+++CG
Sbjct: 543 FGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDT-WIQCNKRDVLCG 601

Query: 551 RLVCTYPTRKP-FHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIG 605
            L+CT     P   + +G++    V    R   C     KL   V D   V++G+ C   
Sbjct: 602 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQ 660

Query: 606 RVCVNRECVESRIIKASAHVCSQQ---CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSI 662
            +C+   C+       S  + S++   CSG+GVC +  KC C+  +   +C       + 
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN------TY 714

Query: 663 FPEEDMGSIMERASGK-TENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSE 721
           FP  D        SG     T ++  +IA  IL++   + +     K  + ++ + P  +
Sbjct: 715 FPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKN-YREQRQLPQGD 773

Query: 722 -SKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSR 773
             K  G   ++            Y+      S++ A +SK +S   + +++ R
Sbjct: 774 YVKKPGDGDSF------------YSDIPPGVSTNSASSSKKRSNGLSHSWSER 814


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,293,426
Number of Sequences: 37866
Number of extensions: 1501650
Number of successful extensions: 7434
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 143
Number of HSP's that attempted gapping in prelim test: 5372
Number of HSP's gapped (non-prelim): 1620
length of query: 787
length of database: 18,247,518
effective HSP length: 110
effective length of query: 677
effective length of database: 14,082,258
effective search space: 9533688666
effective search space used: 9533688666
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.