Search of human proteins with 98985828

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|98985828 ADAM metallopeptidase domain 28 isoform 1
preproprotein [Homo sapiens]
         (775 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...  1635   0.0  
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot...  1102   0.0  
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   559   e-159
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   494   e-140
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   437   e-122
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   430   e-120
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   430   e-120
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   410   e-114
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   405   e-113
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   394   e-109
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   392   e-109
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   392   e-109
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   392   e-109
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   392   e-109
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...   392   e-109
gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens]              392   e-109
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   382   e-106
gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens]            353   3e-97
gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens]            353   3e-97
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   325   1e-88
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   311   1e-84
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...   311   1e-84
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi...   311   1e-84
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   310   3e-84
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   310   3e-84
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   310   3e-84
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   309   6e-84
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   309   6e-84
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   309   6e-84
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   309   6e-84

>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score = 1635 bits (4235), Expect = 0.0
 Identities = 775/775 (100%), Positives = 775/775 (100%)

Query: 1   MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
           MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK
Sbjct: 1   MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60

Query: 61  MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
           MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS
Sbjct: 61  MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120

Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
           ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL
Sbjct: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180

Query: 181 QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240
           QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM
Sbjct: 181 QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240

Query: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300
           LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE
Sbjct: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300

Query: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI 360
           LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI
Sbjct: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI 360

Query: 361 CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED 420
           CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED
Sbjct: 361 CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED 420

Query: 421 CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG 480
           CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG
Sbjct: 421 CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG 480

Query: 481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSK 540
           KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSK
Sbjct: 481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNRNEGGSK 540

Query: 541 YGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMV 600
           YGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMV
Sbjct: 541 YGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTSQEIGMV 600

Query: 601 ANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSS 660
           ANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSS
Sbjct: 601 ANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSS 660

Query: 661 VVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVK 720
           VVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVK
Sbjct: 661 VVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVK 720

Query: 721 AVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA 775
           AVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA
Sbjct: 721 AVQPQEMSQMKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNPKA 775


>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
           [Homo sapiens]
          Length = 540

 Score = 1102 bits (2851), Expect = 0.0
 Identities = 524/531 (98%), Positives = 524/531 (98%)

Query: 1   MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
           MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK
Sbjct: 1   MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60

Query: 61  MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
           MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS
Sbjct: 61  MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120

Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
           ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL
Sbjct: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180

Query: 181 QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240
           QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM
Sbjct: 181 QQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240

Query: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300
           LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE
Sbjct: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300

Query: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI 360
           LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI
Sbjct: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTI 360

Query: 361 CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED 420
           CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED
Sbjct: 361 CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGED 420

Query: 421 CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG 480
           CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG
Sbjct: 421 CDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNG 480

Query: 481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSC 531
           KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPG       C
Sbjct: 481 KSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPC 531


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  559 bits (1440), Expect = e-159
 Identities = 294/728 (40%), Positives = 420/728 (57%), Gaps = 40/728 (5%)

Query: 1   MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQE---QFETEL 57
           ML G + + +LL   V   K + GV+  ++V P +L  + KR+       +    +E EL
Sbjct: 1   MLPGCIFLMILLIPQVKE-KFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEEL 59

Query: 58  KYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVS 117
            Y++ +N K  VL+L +++  L   Y+ET+Y+  G+  T  PQIMD C+YQG I++E  S
Sbjct: 60  LYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDS 119

Query: 118 DASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYN---PDEKNYDSTCGMDGV 174
            ASISTC GLRG+F   DQRY IEP+   + D  EH +FKYN   P   NY  T      
Sbjct: 120 AASISTCNGLRGFFRINDQRYLIEPVK--YSDEGEHLVFKYNLRVPYGANYSCT------ 171

Query: 175 LWAHDLQQNIALPATKLVKLKDRKVQ--EHEKYIEYYLVLDNGEFKRYNENQDEIRKRVF 232
               +L              +D K++    EKY+E ++V D+  ++R     +++R R++
Sbjct: 172 ----ELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIW 227

Query: 233 EMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDI 292
            M N+VNM+YK LN HV LVG+EIWT +DKI++  N   TL  FS W+  +L  RK  D 
Sbjct: 228 GMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDH 287

Query: 293 AQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD 351
             L++   L     G+++   MC PY S  +++D   +   +A  MAH++GHN GM HD+
Sbjct: 288 VVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDE 347

Query: 352 YSCKCPSTICVMDKALSFYIPT-DFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPIC 410
           + C CPS  CVMD   S  IP   FS CS+  Y ++ +D    C+ N P P +      C
Sbjct: 348 FPCTCPSGKCVMDSDGS--IPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405

Query: 411 GNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKD 470
           GN+ ++ GE+CDCG ++ECTN CCDA TC +K  F CA GECCE CQ KKAG +CRPAKD
Sbjct: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKD 465

Query: 471 ECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKS 530
           ECD PEMC G S  CP D+F+VNGFPC + +G+C MG CPT ++QC+EL+      +   
Sbjct: 466 ECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDI 525

Query: 531 CYNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNL------------PWKGR 578
           CY  N  G+K+GYC+  ++  +PC+  D  CGK++C GG  +             P K  
Sbjct: 526 CYKMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNA 585

Query: 579 IVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAV 638
            V    CKT      S +IG+VA+GTKCG+  VC N EC+++EK Y STNC S+C  + V
Sbjct: 586 TV---KCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPV 642

Query: 639 CDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKD 698
             H LQC CEEG  P  C+++  V + +I+V VL  + V   V+ +++R++   + ++  
Sbjct: 643 DGHGLQCHCEEGQAPVACEETLHVTNITILVVVLVLVIVGIGVLILLVRYRKCIKLKQVQ 702

Query: 699 QRPLSTTG 706
             P  T G
Sbjct: 703 SPPTETLG 710


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  494 bits (1273), Expect = e-140
 Identities = 282/724 (38%), Positives = 394/724 (54%), Gaps = 52/724 (7%)

Query: 4   GLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTI 63
           GL  +  ++  A++  +    +++YEVV P RL     R A  P         + Y +  
Sbjct: 5   GLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRAL-PSHLGLHPERVSYVLGA 63

Query: 64  NGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASIST 123
            G    L+L+KN++LL  GYTETY  + G E+T  P+  D C+YQGH+     S AS+ST
Sbjct: 64  TGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLST 123

Query: 124 CRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQN 183
           C GLRG+F  G   + IEPL     +G  HA+++     ++   T G  GV  + D   +
Sbjct: 124 CAGLRGFFQVGSDLHLIEPLDE-GGEGGRHAVYQ----AEHLLQTAGTCGV--SDDSLGS 176

Query: 184 IALPATKLV---KLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240
           +  P T  V   +  D       +Y+E Y+V+DN EF+    ++  +R RV E+ N+V+ 
Sbjct: 177 LLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLG-SEAAVRHRVLEVVNHVDK 235

Query: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300
           LY+KLN  V LVG+EIW  +D+  ++P+ S TLEN   W+    +RR  HD  QLIT  +
Sbjct: 236 LYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVD 295

Query: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD--YSCKCPS 358
             GTTVG A +S MCS  S  V QDHS N + VA TMAHEMGHN GM HD+    C+C  
Sbjct: 296 FTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQE 355

Query: 359 TI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQL 414
                 C+M  ++    P  FS CS+   + F E   S CL NAP  + ++  P+CGN  
Sbjct: 356 RFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLF 415

Query: 415 VEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDL 474
           VE GE CDCG  E+C N CC++ TC++    QCA G CC++C+ K AG +CRP KD CDL
Sbjct: 416 VERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDL 475

Query: 475 PEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNR 534
            E C+G+   CP+D FQ NG PC    G+C  G CPTL +QC   WGPG + A++SC++ 
Sbjct: 476 EEFCDGRHPECPEDAFQENGTPC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSY 533

Query: 535 NEGGSKYGYCRRVDDTLIPCKAN---DTMCGKLFCQGGSDNLPWKGRIVTFL-TCKTFDP 590
                         D L  CKA+     MCG L C+GG   L   GR +  +  C     
Sbjct: 534 --------------DILPGCKASRYRADMCGVLQCKGGQQPL---GRAICIVDVCHALTT 576

Query: 591 ED-TSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEE 649
           ED T+ E   V  GT+CG  KVC    C D+   Y+S+NCS++C  H VC+H+ +C C  
Sbjct: 577 EDGTAYE--PVPEGTRCGPEKVCWKGRCQDLH-VYRSSNCSAQCHNHGVCNHKQECHCHA 633

Query: 650 GWIPPDCDDSSVVFHFS------IVVGVLFPMAVIFVVVAMVIRHQSSREK-QKKDQRPL 702
           GW PP C       H +       VV VL  +AV+ V +A +I ++ +R +   ++  P 
Sbjct: 634 GWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPK 693

Query: 703 STTG 706
           +T G
Sbjct: 694 TTMG 697


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  437 bits (1124), Expect = e-122
 Identities = 244/705 (34%), Positives = 365/705 (51%), Gaps = 45/705 (6%)

Query: 43  EAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIM 102
           +  E   +E+   + + ++   G+  +L L+KN+ L AP YTET+Y S+G   TT+ ++ 
Sbjct: 51  KTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLE 110

Query: 103 DDCYYQGHILNEKVSDASISTCRGLRGYFS-QGDQRYFIEPLSPIHRDGQEHALFKYNPD 161
           D C+Y G +   ++S  ++STCRG+RG  +   +  Y IEPL     D +   L   +  
Sbjct: 111 DHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLP----DSKGQHLIYRSEH 166

Query: 162 EKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHE----KYIEYYLVLDNGEF 217
            K     CG +    +    ++ AL  T+  K + R+++  +    KY+E YLV D  EF
Sbjct: 167 LKPPPGNCGFEH---SKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEF 223

Query: 218 KRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFS 277
           ++   +QD  + ++ E+ANYV+  Y+ LN  +ALVG+E+WT  +  +++ N   TL +F 
Sbjct: 224 QKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFL 283

Query: 278 KWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGT 336
            WR  +L++ K HD AQLIT     GTT+GLA +  MCS Y S GV  DHS+N + VA T
Sbjct: 284 SWRRKLLAQ-KYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAAT 342

Query: 337 MAHEMGHNFGMFHDDYSCKCPSTI---CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSN 393
           MAHEMGHNFGM HD   C   S     C+M  A     P  F+ C+R   D++ +     
Sbjct: 343 MAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGM 402

Query: 394 CLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECC 453
           CL N P    +     CGN  +E GE+CDCG  EEC N CC+A  C ++   +CA G CC
Sbjct: 403 CLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCC 462

Query: 454 EKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQ 513
            +C+    G +CR    +CDLPE C GKS +CP + +Q++G PC  G+ +C  G C T Q
Sbjct: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522

Query: 514 EQCTELWGPGTEVADKSCYNR-NEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQGGSD 571
           EQC +LWGPG   A   C+ + N  G  +G C + ++     C   D  CGK+ CQ  S+
Sbjct: 523 EQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQ-SSE 581

Query: 572 NLPWKGRIVTFLTCKTFD--------------PEDTSQEI--GMVANGTKCGDNKVCINA 615
             P +   V   T    +              PE+    +  G+V  GTKCG N +C   
Sbjct: 582 ARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEG 641

Query: 616 ECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCD--------DSSVVFHFSI 667
           +C +    +++  C  KC GH VC++   C C  GW PP C+        DS  +   S+
Sbjct: 642 QCRN-TSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESV 700

Query: 668 VVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQ 712
              V   +  I V+  +++ +   R+  K  Q   S   ++  +Q
Sbjct: 701 GPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQ 745


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  430 bits (1105), Expect = e-120
 Identities = 233/637 (36%), Positives = 339/637 (53%), Gaps = 52/637 (8%)

Query: 57  LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQ---IMDDCYYQGHILN 113
           L  ++    K  ++ L++N+ L+A  +TET+Y   G +++ +     I+  CYY GH+  
Sbjct: 68  LNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRG 127

Query: 114 EKVSDASISTCRGLRGYFSQGDQRYFIEPL-SPIHRDGQEHALFKYNPDEK--NYDSTCG 170
              S  S+STC GLRG     ++ Y +EP+ S  +R       +K  P +K  +   +CG
Sbjct: 128 YSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-------YKLFPAKKLKSVRGSCG 180

Query: 171 MDGVLWAHDLQQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQ 224
                 +H    N+A       P+    +   R+  +  KY+E  +V DN EF+R  ++ 
Sbjct: 181 ------SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234

Query: 225 DEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVL 284
           +++++R+ E+AN+V+  Y+ LN  + LVG+E+W D DK  ++ +   +L  F  WR   L
Sbjct: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294

Query: 285 SRRKRHDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGH 343
             RK HD AQL++     GTT+G+A + +MC+   S G+V DHSDN L  A T+AHE+GH
Sbjct: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354

Query: 344 NFGMFHD--DYSCKCPSTI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397
           NFGM HD  D  C C   +    C+M+ +  +  P  FSSCSR   +   E  +  CLFN
Sbjct: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414

Query: 398 APLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQ 457
            P   +      CGN+ VE GE+CDCG  EEC N CC+A TC +K    CA G CCE CQ
Sbjct: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474

Query: 458 FKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCT 517
            K AG  CR + + CDLPE C G S +CP + +  +G  C    G+C  G C T ++QC 
Sbjct: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534

Query: 518 ELWGPGTEVADKSCYNR-NEGGSKYGYCRRVD-DTLIPCKANDTMCGKLFCQGGSD---- 571
            LWGPG + A   C+ R N  G  YG C +V   +   C+  D  CGK+ CQGG+     
Sbjct: 535 TLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVI 594

Query: 572 ---------NLPWK--GRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDI 620
                    N+P +  GRI+   T       D   + G+V  GTKC D K+C+N +C +I
Sbjct: 595 GTNAVSIETNIPLQQGGRILCRGTHVYLG--DDMPDPGLVLAGTKCADGKICLNRQCQNI 652

Query: 621 EKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCD 657
              +    C+ +C G  VC++   C CE  W PP CD
Sbjct: 653 -SVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCD 688


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  430 bits (1105), Expect = e-120
 Identities = 233/637 (36%), Positives = 339/637 (53%), Gaps = 52/637 (8%)

Query: 57  LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQ---IMDDCYYQGHILN 113
           L  ++    K  ++ L++N+ L+A  +TET+Y   G +++ +     I+  CYY GH+  
Sbjct: 68  LNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRG 127

Query: 114 EKVSDASISTCRGLRGYFSQGDQRYFIEPL-SPIHRDGQEHALFKYNPDEK--NYDSTCG 170
              S  S+STC GLRG     ++ Y +EP+ S  +R       +K  P +K  +   +CG
Sbjct: 128 YSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-------YKLFPAKKLKSVRGSCG 180

Query: 171 MDGVLWAHDLQQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQ 224
                 +H    N+A       P+    +   R+  +  KY+E  +V DN EF+R  ++ 
Sbjct: 181 ------SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234

Query: 225 DEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVL 284
           +++++R+ E+AN+V+  Y+ LN  + LVG+E+W D DK  ++ +   +L  F  WR   L
Sbjct: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294

Query: 285 SRRKRHDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGH 343
             RK HD AQL++     GTT+G+A + +MC+   S G+V DHSDN L  A T+AHE+GH
Sbjct: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354

Query: 344 NFGMFHD--DYSCKCPSTI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397
           NFGM HD  D  C C   +    C+M+ +  +  P  FSSCSR   +   E  +  CLFN
Sbjct: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414

Query: 398 APLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQ 457
            P   +      CGN+ VE GE+CDCG  EEC N CC+A TC +K    CA G CCE CQ
Sbjct: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474

Query: 458 FKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCT 517
            K AG  CR + + CDLPE C G S +CP + +  +G  C    G+C  G C T ++QC 
Sbjct: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534

Query: 518 ELWGPGTEVADKSCYNR-NEGGSKYGYCRRVD-DTLIPCKANDTMCGKLFCQGGSD---- 571
            LWGPG + A   C+ R N  G  YG C +V   +   C+  D  CGK+ CQGG+     
Sbjct: 535 TLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVI 594

Query: 572 ---------NLPWK--GRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDI 620
                    N+P +  GRI+   T       D   + G+V  GTKC D K+C+N +C +I
Sbjct: 595 GTNAVSIETNIPLQQGGRILCRGTHVYLG--DDMPDPGLVLAGTKCADGKICLNRQCQNI 652

Query: 621 EKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCD 657
              +    C+ +C G  VC++   C CE  W PP CD
Sbjct: 653 -SVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCD 688


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  410 bits (1055), Expect = e-114
 Identities = 250/784 (31%), Positives = 379/784 (48%), Gaps = 72/784 (9%)

Query: 1   MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
           +L GL  V  +L  A    ++   +  YE++ P RL    +REA  P     +  ++ Y 
Sbjct: 18  LLLGL--VGPVLGAARPGFQQTSHLSSYEIITPWRL-TRERREAPRP-----YSKQVSYV 69

Query: 61  MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
           +   GK  +++L++NK+LL   +    YN  G  IT  P I + C+Y+G++     S  +
Sbjct: 70  IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129

Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
           +S C GLRG     +  Y IEPL   +    EH +++ + D       CG+       D+
Sbjct: 130 LSDCFGLRGLLHLENASYGIEPLQ--NSSHFEHIIYRMD-DVYKEPLKCGVSN----KDI 182

Query: 181 QQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEM 234
           ++  A       P+   +  + R V    +Y+E ++V+D   +     NQ  +R+ +  +
Sbjct: 183 EKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILL 242

Query: 235 ANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQ 294
           ANY++ +Y  LN  + LVG+EIWT+ + I I   A   L NF +WR   L  R+RHD AQ
Sbjct: 243 ANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQ 302

Query: 295 LITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRV-AGTMAHEMGHNFGMFHDD-Y 352
           L+      GT  G+AF+ T+CS    G +       +   A  +AHE+GHN GM HDD  
Sbjct: 303 LVLKKGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGR 361

Query: 353 SCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGN 412
            C C +  C+M+   S     +FSSCS   ++K   +K  NCL N P P +  S P CGN
Sbjct: 362 DCSCGAKSCIMNSGASG--SRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGN 419

Query: 413 QLVEMGEDCDCGTSEECT-NICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDE 471
           +LV+ GE+CDCGT +EC  + CC+  TCK+K+  +CA G+CC+ C+F   G +CR    E
Sbjct: 420 KLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE 479

Query: 472 CDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSC 531
           CD+PE CNG S  C  D F  NG+PC + K +C  G C     QC  ++G   + A K C
Sbjct: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539

Query: 532 Y-NRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKT--- 587
           +   N  G ++G C    +    C   + +CGKL C+   + +P  G +   +   +   
Sbjct: 540 FIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQE-IPVFGIVPAIIQTPSRGT 598

Query: 588 ------FDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDH 641
                 F       + GMV  GTKCG  K+C N +CVD        +   KC GH VC+ 
Sbjct: 599 KCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNS 658

Query: 642 ELQCQCEEGWIPPDCD----------------------DSSVVFHFSIVVGVLFPMAVIF 679
              C CE GW PP+C+                      D  +VF F IV     P+ ++ 
Sbjct: 659 NKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIV-----PL-IVC 712

Query: 680 VVVAMVIRHQSSREK-QKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLP 738
            +   + R Q  R   +KK  +   + G       R+P  V    P+ +S + P   ++P
Sbjct: 713 AIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSV----PRHVSPVTP-PREVP 767

Query: 739 VEGN 742
           +  N
Sbjct: 768 IYAN 771


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  405 bits (1041), Expect = e-113
 Identities = 227/620 (36%), Positives = 325/620 (52%), Gaps = 39/620 (6%)

Query: 65  GKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTC 124
           G+  +L L+KN  LLAPGY ET+Y   G+ +  +P   D C+YQG +     S   + TC
Sbjct: 74  GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133

Query: 125 RGLRGYFSQG-DQRYFIEPLSPI-HRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQ 182
            G+ G  +   +  Y++ P  P   +D   H +F+       +  TCG       H    
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRME-QLLTWKGTCG-------HRDPG 185

Query: 183 NIA----LPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238
           N A    LP     + + R+ +   KY+E Y+V D+  F   + N +  ++R+ E+ANYV
Sbjct: 186 NKAGMTSLPGGPQSRGR-REARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244

Query: 239 NMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITA 298
           + L + L+  VAL G+E+WT++D+ ++T +A+ TL  F +WR  + ++R  HD AQL+T 
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRP-HDSAQLLTG 303

Query: 299 TELAGTTVGLAFMSTMC-SPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSC--- 354
               G TVGLA +  MC +  S GV  DHS+  +  A TMAHE+GH+ G+ HD   C   
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363

Query: 355 -KCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQ 413
               S  CVM  A     P  FS+CSR     FF      CL NAP P   +   +CGN 
Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423

Query: 414 LVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECD 473
            VE GE+CDCG  +EC ++CC A  C ++   QCA G+CC +C  K AG +CR A  +CD
Sbjct: 424 FVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCD 483

Query: 474 LPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYN 533
           LPE C G S +CP D + ++G PC  G G+C  G CPTL++QC +LWGPG+  A ++C+ 
Sbjct: 484 LPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQ 543

Query: 534 -RNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPE 591
             N  G  +G C +  +   +PC   D +CGKL CQGG  +L     +    T      E
Sbjct: 544 VVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQE 603

Query: 592 DTSQ-------------EIGMVANGTKCGDNKVCINAECVDIEKAYKS-TNCSSKCKGHA 637
            T +              +G+V  GT+CG   VC +  C   + A++    C + C  H 
Sbjct: 604 VTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRC--RKNAFQELQRCLTACHSHG 661

Query: 638 VCDHELQCQCEEGWIPPDCD 657
           VC+    C C  GW PP CD
Sbjct: 662 VCNSNHNCHCAPGWAPPFCD 681


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  394 bits (1013), Expect = e-109
 Identities = 249/753 (33%), Positives = 369/753 (49%), Gaps = 42/753 (5%)

Query: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
           Q      L+ K+ ++G   +L L +N+ L+    T  +Y   G  + +    +++C YQG
Sbjct: 62  QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121

Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
            +     S  SI TC GLRG      +R +     P   D Q   +     D      TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179

Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
            +      H  Q+    P  +    + R V    K +E  +V D+ E ++Y + Q  +  
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237

Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
           R  E+A  ++  ++ LN  VALVG+E WT +D ++I+PN + TLENF  WR + L  R  
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297

Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
           HD AQL+T T  +G TVG+A  +++CSP +S GV  DHS ++L VA ++AHE+GH+ G+ 
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357

Query: 349 HD--DYSCKCP----STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
           HD    SC CP    +  C+M+ +  F    +FS+CSR + +K   D + +CLF   LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
                  CGN  VE GE CDCG  ++C + CCD+ TC+++   QCA  G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476

Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
           G  CRP + +CDLPE C G S  CP D    +G PC  G+  C+ G C +  +QC  LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536

Query: 522 PGTEVADKSC-YNRNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQ--------GGSD 571
           PG + A   C    N  G+ +G C R    + + C   D +CG+L CQ        G   
Sbjct: 537 PGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIR 596

Query: 572 NLPWKGRIV--TFLTCKTFDPE---DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKS 626
           +L W+   V  T L C     +   D +Q + +   GT CG   VCI+  C  ++    +
Sbjct: 597 DLLWETIDVNGTELNCSWVHLDLGSDVAQPL-LTLPGTACGPGLVCIDHRCQRVD-LLGA 654

Query: 627 TNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVI 686
             C SKC GH VCD    C CEEGW PPDC  + +    S+  G+L  + V+ V+V +  
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDC-TTQLKATSSLTTGLLLSLLVLLVLVMLGA 713

Query: 687 RH-QSSREKQKKDQRPLSTTGTR-----PHKQKRKPQ---MVKAVQPQEMSQMKPHVYDL 737
            +   +R  Q+  Q    T   R     P ++   PQ   + +  + Q  ++  P    L
Sbjct: 714 SYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPPRKPL 773

Query: 738 PV--EGNEPPASFHKDTNALPPTVFKDNPVSTP 768
           P   +G  P          +PP V    P   P
Sbjct: 774 PADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPP 806


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  392 bits (1007), Expect = e-109
 Identities = 230/658 (34%), Positives = 338/658 (51%), Gaps = 31/658 (4%)

Query: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
           Q      L+ K+ ++G   +L L +N+ L+    T  +Y   G  + +    +++C YQG
Sbjct: 62  QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121

Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
            +     S  SI TC GLRG      +R +     P   D Q   +     D      TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179

Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
            +      H  Q+    P  +    + R V    K +E  +V D+ E ++Y + Q  +  
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237

Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
           R  E+A  ++  ++ LN  VALVG+E WT +D ++I+PN + TLENF  WR + L  R  
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297

Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
           HD AQL+T T  +G TVG+A  +++CSP +S GV  DHS ++L VA ++AHE+GH+ G+ 
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357

Query: 349 HD--DYSCKCP----STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
           HD    SC CP    +  C+M+ +  F    +FS+CSR + +K   D + +CLF   LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
                  CGN  VE GE CDCG  ++C + CCD+ TC+++   QCA  G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476

Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
           G  CRP + +CDLPE C G S  CP D    +G PC  G+  C+ G C +  +QC  LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536

Query: 522 PGTEVADKSC-YNRNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQ--------GGSD 571
           PG + A   C    N  G+ +G C R    + + C   D +CG+L CQ        G   
Sbjct: 537 PGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIR 596

Query: 572 NLPWKGRIV--TFLTCKTFDPE---DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKS 626
           +L W+   V  T L C     +   D +Q + +   GT CG   VCI+  C  ++    +
Sbjct: 597 DLLWETIDVNGTELNCSWVHLDLGSDVAQPL-LTLPGTACGPGLVCIDHRCQRVD-LLGA 654

Query: 627 TNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAM 684
             C SKC GH VCD    C CEEGW PPDC  + +    S+  G+L  + V+ V+V +
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDC-TTQLKATSSLTTGLLLSLLVLLVLVML 711


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  392 bits (1007), Expect = e-109
 Identities = 230/658 (34%), Positives = 338/658 (51%), Gaps = 31/658 (4%)

Query: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
           Q      L+ K+ ++G   +L L +N+ L+    T  +Y   G  + +    +++C YQG
Sbjct: 62  QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121

Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
            +     S  SI TC GLRG      +R +     P   D Q   +     D      TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179

Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
            +      H  Q+    P  +    + R V    K +E  +V D+ E ++Y + Q  +  
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237

Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
           R  E+A  ++  ++ LN  VALVG+E WT +D ++I+PN + TLENF  WR + L  R  
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297

Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
           HD AQL+T T  +G TVG+A  +++CSP +S GV  DHS ++L VA ++AHE+GH+ G+ 
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357

Query: 349 HD--DYSCKCP----STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
           HD    SC CP    +  C+M+ +  F    +FS+CSR + +K   D + +CLF   LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
                  CGN  VE GE CDCG  ++C + CCD+ TC+++   QCA  G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476

Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
           G  CRP + +CDLPE C G S  CP D    +G PC  G+  C+ G C +  +QC  LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536

Query: 522 PGTEVADKSC-YNRNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQ--------GGSD 571
           PG + A   C    N  G+ +G C R    + + C   D +CG+L CQ        G   
Sbjct: 537 PGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIR 596

Query: 572 NLPWKGRIV--TFLTCKTFDPE---DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKS 626
           +L W+   V  T L C     +   D +Q + +   GT CG   VCI+  C  ++    +
Sbjct: 597 DLLWETIDVNGTELNCSWVHLDLGSDVAQPL-LTLPGTACGPGLVCIDHRCQRVD-LLGA 654

Query: 627 TNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAM 684
             C SKC GH VCD    C CEEGW PPDC  + +    S+  G+L  + V+ V+V +
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDC-TTQLKATSSLTTGLLLSLLVLLVLVML 711


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  392 bits (1007), Expect = e-109
 Identities = 230/658 (34%), Positives = 338/658 (51%), Gaps = 31/658 (4%)

Query: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
           Q      L+ K+ ++G   +L L +N+ L+    T  +Y   G  + +    +++C YQG
Sbjct: 62  QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121

Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
            +     S  SI TC GLRG      +R +     P   D Q   +     D      TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179

Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
            +      H  Q+    P  +    + R V    K +E  +V D+ E ++Y + Q  +  
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237

Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
           R  E+A  ++  ++ LN  VALVG+E WT +D ++I+PN + TLENF  WR + L  R  
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297

Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
           HD AQL+T T  +G TVG+A  +++CSP +S GV  DHS ++L VA ++AHE+GH+ G+ 
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357

Query: 349 HD--DYSCKCP----STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
           HD    SC CP    +  C+M+ +  F    +FS+CSR + +K   D + +CLF   LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
                  CGN  VE GE CDCG  ++C + CCD+ TC+++   QCA  G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476

Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
           G  CRP + +CDLPE C G S  CP D    +G PC  G+  C+ G C +  +QC  LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536

Query: 522 PGTEVADKSC-YNRNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQ--------GGSD 571
           PG + A   C    N  G+ +G C R    + + C   D +CG+L CQ        G   
Sbjct: 537 PGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIR 596

Query: 572 NLPWKGRIV--TFLTCKTFDPE---DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKS 626
           +L W+   V  T L C     +   D +Q + +   GT CG   VCI+  C  ++    +
Sbjct: 597 DLLWETIDVNGTELNCSWVHLDLGSDVAQPL-LTLPGTACGPGLVCIDHRCQRVD-LLGA 654

Query: 627 TNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAM 684
             C SKC GH VCD    C CEEGW PPDC  + +    S+  G+L  + V+ V+V +
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDC-TTQLKATSSLTTGLLLSLLVLLVLVML 711


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  392 bits (1007), Expect = e-109
 Identities = 230/658 (34%), Positives = 338/658 (51%), Gaps = 31/658 (4%)

Query: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
           Q      L+ K+ ++G   +L L +N+ L+    T  +Y   G  + +    +++C YQG
Sbjct: 62  QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121

Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
            +     S  SI TC GLRG      +R +     P   D Q   +     D      TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179

Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
            +      H  Q+    P  +    + R V    K +E  +V D+ E ++Y + Q  +  
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237

Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
           R  E+A  ++  ++ LN  VALVG+E WT +D ++I+PN + TLENF  WR + L  R  
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297

Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
           HD AQL+T T  +G TVG+A  +++CSP +S GV  DHS ++L VA ++AHE+GH+ G+ 
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357

Query: 349 HD--DYSCKCP----STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
           HD    SC CP    +  C+M+ +  F    +FS+CSR + +K   D + +CLF   LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
                  CGN  VE GE CDCG  ++C + CCD+ TC+++   QCA  G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476

Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
           G  CRP + +CDLPE C G S  CP D    +G PC  G+  C+ G C +  +QC  LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536

Query: 522 PGTEVADKSC-YNRNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQ--------GGSD 571
           PG + A   C    N  G+ +G C R    + + C   D +CG+L CQ        G   
Sbjct: 537 PGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIR 596

Query: 572 NLPWKGRIV--TFLTCKTFDPE---DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKS 626
           +L W+   V  T L C     +   D +Q + +   GT CG   VCI+  C  ++    +
Sbjct: 597 DLLWETIDVNGTELNCSWVHLDLGSDVAQPL-LTLPGTACGPGLVCIDHRCQRVD-LLGA 654

Query: 627 TNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAM 684
             C SKC GH VCD    C CEEGW PPDC  + +    S+  G+L  + V+ V+V +
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDC-TTQLKATSSLTTGLLLSLLVLLVLVML 711


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score =  392 bits (1007), Expect = e-109
 Identities = 230/658 (34%), Positives = 338/658 (51%), Gaps = 31/658 (4%)

Query: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
           Q      L+ K+ ++G   +L L +N+ L+    T  +Y   G  + +    +++C YQG
Sbjct: 62  QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121

Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
            +     S  SI TC GLRG      +R +     P   D Q   +     D      TC
Sbjct: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179

Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
            +      H  Q+    P  +    + R V    K +E  +V D+ E ++Y + Q  +  
Sbjct: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237

Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
           R  E+A  ++  ++ LN  VALVG+E WT +D ++I+PN + TLENF  WR + L  R  
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297

Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
           HD AQL+T T  +G TVG+A  +++CSP +S GV  DHS ++L VA ++AHE+GH+ G+ 
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357

Query: 349 HD--DYSCKCP----STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
           HD    SC CP    +  C+M+ +  F    +FS+CSR + +K   D + +CLF   LP+
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
                  CGN  VE GE CDCG  ++C + CCD+ TC+++   QCA  G CC+ CQ + +
Sbjct: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476

Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
           G  CRP + +CDLPE C G S  CP D    +G PC  G+  C+ G C +  +QC  LWG
Sbjct: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536

Query: 522 PGTEVADKSC-YNRNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQ--------GGSD 571
           PG + A   C    N  G+ +G C R    + + C   D +CG+L CQ        G   
Sbjct: 537 PGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIR 596

Query: 572 NLPWKGRIV--TFLTCKTFDPE---DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKS 626
           +L W+   V  T L C     +   D +Q + +   GT CG   VCI+  C  ++    +
Sbjct: 597 DLLWETIDVNGTELNCSWVHLDLGSDVAQPL-LTLPGTACGPGLVCIDHRCQRVD-LLGA 654

Query: 627 TNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAM 684
             C SKC GH VCD    C CEEGW PPDC  + +    S+  G+L  + V+ V+V +
Sbjct: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDC-TTQLKATSSLTTGLLLSLLVLLVLVML 711


>gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens]
          Length = 470

 Score =  392 bits (1006), Expect = e-109
 Identities = 203/450 (45%), Positives = 290/450 (64%), Gaps = 14/450 (3%)

Query: 5   LLPVS-LLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPE-----QQEQFETELK 58
           LLPV  L++     AIK+ P +  +E+V P +LH LHKRE K  +     ++E++E E++
Sbjct: 18  LLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQ 77

Query: 59  YKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSD 118
           Y+M +NG+  +L L+K K+LL P YTET Y+  G+EITT P+ M+ CYY+G+ILNEK S 
Sbjct: 78  YQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSV 137

Query: 119 ASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWA 177
           ASISTC GLRGYF+   QRY I+PL     D +EHA+F  N +E++  + TCG+      
Sbjct: 138 ASISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST--- 192

Query: 178 HDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANY 237
            D +Q     +  L   +       +KYI+ YLVLDN  +K YNEN   IR  VF++ N 
Sbjct: 193 -DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNL 251

Query: 238 VNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLIT 297
           +N++Y  ++  VALVGMEIW+D DKIK+ P+AS T +NF +W  S L + K HD AQL++
Sbjct: 252 LNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLS 310

Query: 298 ATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCP 357
                   VGLA  +++CSP SV V++    N + + G M+HE+GH  GM    ++ KCP
Sbjct: 311 GISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCP 370

Query: 358 STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEM 417
           S  CVM++ LS   P DFS+  R  ++++   +   CL  AP+PT+I++TP+CGN L+E+
Sbjct: 371 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 430

Query: 418 GEDCDCGTSEECTNICCDAKTCKIKATFQC 447
           GEDCDCG+ +ECTN+CC+A TCK+K    C
Sbjct: 431 GEDCDCGSPKECTNLCCEALTCKLKPGTDC 460


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  382 bits (981), Expect = e-106
 Identities = 220/619 (35%), Positives = 313/619 (50%), Gaps = 63/619 (10%)

Query: 65  GKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTC 124
           G+  +L L+KN  LLAPGY ET+Y   G+ +  +P   D C+YQG +     S   + TC
Sbjct: 74  GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133

Query: 125 RGLRGYFSQG-DQRYFIEPLSPI-HRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQ 182
            G+ G  +   +  Y++ P  P   +D   H +F+       +  TCG       H    
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRME-QLLTWKGTCG-------HRDPG 185

Query: 183 NIA----LPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238
           N A    LP     + + R+ +   KY+E Y+V D+  F   + N +  ++R+ E+ANYV
Sbjct: 186 NKAGMTSLPGGPQSRGR-REARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244

Query: 239 NMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITA 298
           + L + L+  VAL G+E+WT++D+ ++T +A+ TL  F +WR  + ++R  HD AQL+T 
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRP-HDSAQLLTG 303

Query: 299 TELAGTTVGLAFMSTMC-SPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSC--- 354
               G TVGLA +  MC +  S GV  DHS+  +  A TMAHE+GH+ G+ HD   C   
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363

Query: 355 -KCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQ 413
               S  CVM  A     P  FS+CSR     FF      CL NAP P   +   +CGN 
Sbjct: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423

Query: 414 LVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECD 473
            VE GE+CDCG  +EC ++CC A  C ++   QCA G+CC +C  K AG +CR A  +CD
Sbjct: 424 FVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCD 483

Query: 474 LPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYN 533
           LPE C G S +CP D + ++G PC  G G+C  G CPTL++QC +LWGPG+  A ++C+ 
Sbjct: 484 LPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQ 543

Query: 534 -RNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPE 591
             N  G  +G C +  +   +PC   D +CGKL CQGG  +L     +    T      E
Sbjct: 544 VVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQE 603

Query: 592 DTSQ-------------EIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAV 638
            T +              +G+V  GT+CG                              V
Sbjct: 604 VTCRGALALPSAQLDLLGLGLVEPGTQCGP---------------------------RMV 636

Query: 639 CDHELQCQCEEGWIPPDCD 657
           C+    C C  GW PP CD
Sbjct: 637 CNSNHNCHCAPGWAPPFCD 655


>gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
          Length = 391

 Score =  353 bits (907), Expect = 3e-97
 Identities = 179/388 (46%), Positives = 251/388 (64%), Gaps = 8/388 (2%)

Query: 61  MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
           M +NG+  +L L+K K+LL P YTET Y+  G+EITT P+ M+ CYY+G+ILNEK S AS
Sbjct: 1   MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60

Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWAHD 179
           ISTC GLRGYF+   QRY I+PL     D +EHA+F  N +E++  + TCG+       D
Sbjct: 61  ISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST----D 114

Query: 180 LQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVN 239
            +Q     +  L   +       +KYI+ YLVLDN  +K YNEN   IR  VF++ N +N
Sbjct: 115 GKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLN 174

Query: 240 MLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITAT 299
           ++Y  ++  VALVGMEIW+D DKIK+ P+AS T +NF +W  S L + K HD AQL++  
Sbjct: 175 VIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLSGI 233

Query: 300 ELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPST 359
                 VGLA  +++CSP SV V++    N + + G M+HE+GH  GM    ++ KCPS 
Sbjct: 234 SFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSG 293

Query: 360 ICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGE 419
            CVM++ LS   P DFS+  R  ++++   +   CL  AP+PT+I++TP+CGN L+E+GE
Sbjct: 294 SCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGE 353

Query: 420 DCDCGTSEECTNICCDAKTCKIKATFQC 447
           DCDCG+ +ECTN+CC+A TCK+K    C
Sbjct: 354 DCDCGSPKECTNLCCEALTCKLKPGTDC 381


>gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
          Length = 391

 Score =  353 bits (907), Expect = 3e-97
 Identities = 179/388 (46%), Positives = 251/388 (64%), Gaps = 8/388 (2%)

Query: 61  MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
           M +NG+  +L L+K K+LL P YTET Y+  G+EITT P+ M+ CYY+G+ILNEK S AS
Sbjct: 1   MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60

Query: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWAHD 179
           ISTC GLRGYF+   QRY I+PL     D +EHA+F  N +E++  + TCG+       D
Sbjct: 61  ISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST----D 114

Query: 180 LQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVN 239
            +Q     +  L   +       +KYI+ YLVLDN  +K YNEN   IR  VF++ N +N
Sbjct: 115 GKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLN 174

Query: 240 MLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITAT 299
           ++Y  ++  VALVGMEIW+D DKIK+ P+AS T +NF +W  S L + K HD AQL++  
Sbjct: 175 VIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLSGI 233

Query: 300 ELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPST 359
                 VGLA  +++CSP SV V++    N + + G M+HE+GH  GM    ++ KCPS 
Sbjct: 234 SFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSG 293

Query: 360 ICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGE 419
            CVM++ LS   P DFS+  R  ++++   +   CL  AP+PT+I++TP+CGN L+E+GE
Sbjct: 294 SCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGE 353

Query: 420 DCDCGTSEECTNICCDAKTCKIKATFQC 447
           DCDCG+ +ECTN+CC+A TCK+K    C
Sbjct: 354 DCDCGSPKECTNLCCEALTCKLKPGTDC 381


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  325 bits (832), Expect = 1e-88
 Identities = 201/652 (30%), Positives = 311/652 (47%), Gaps = 49/652 (7%)

Query: 29  EVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYY 88
           EVV P+++     R AK P         L Y +   G+  +++++ NK L A       Y
Sbjct: 91  EVVIPLKVIS-RGRGAKAPGW-------LSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTY 142

Query: 89  NSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRG-LRGYFSQGDQRYFIEPLSPIH 147
                 +   P I DDCYY G++     S  ++STC G   G     D  Y I+P+S   
Sbjct: 143 TEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSA 202

Query: 148 RDGQEHALFKYNPDEKNYDST-CGMDGVLWAHDLQQNIALPATKLVKLKDRKVQ---EHE 203
               EH ++K + D+  +    CG+     AH ++  ++   T    LK         H+
Sbjct: 203 TF--EHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFT----LKQSSFVGWWTHQ 256

Query: 204 KYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKI 263
           +++E  +V+DN  +     N   ++  VF + N V+  Y  L   V L G++IWT  + +
Sbjct: 257 RFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPL 316

Query: 264 KITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMC-SPYSVGV 322
             + +    LE+FS W+   L+ R +HD+A L    +  G  +G+A++  +C +P++ GV
Sbjct: 317 PTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIK-DTQGMKLGVAYVKGICQNPFNTGV 375

Query: 323 VQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLS 382
                + L+  A T+ HE+GHN GM HD   C C    C+M       + T FS+CS   
Sbjct: 376 DVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMHAYRK--VTTKFSNCS--- 430

Query: 383 YDKFFEDKLSN--CLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCK 440
           Y ++++  +S+  C+   P P +I     CGN +VE GE+CDCGT  +C    C    C 
Sbjct: 431 YAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCCLLNCT 490

Query: 441 IKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHG 500
           +     CA G CC+ C+F  +G +CR    ECDLPE CNG S  CPDD +  +G  C + 
Sbjct: 491 LHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NV 549

Query: 501 KGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDT 559
              C   TC     QC E++G     A +SCY   N  G+++G+C  V  T + C   D 
Sbjct: 550 NAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDI 609

Query: 560 MCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTS------------QEIGMVANGTKCG 607
           MCG++ C    +N+     ++   T + F   DT+             +IG V +GT CG
Sbjct: 610 MCGRVQC----ENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCG 665

Query: 608 DNKVCINAECVDIEKAYKSTNCSSK-CKGHAVCDHELQCQCEEGWIPPDCDD 658
             K+CI  +C  +   + S  C  K C    +C+++  C C   W PP C D
Sbjct: 666 PEKICIRKKCASM--VHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKD 715


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  311 bits (798), Expect = 1e-84
 Identities = 207/704 (29%), Positives = 322/704 (45%), Gaps = 79/704 (11%)

Query: 56  ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
           +  +++   G   +L +  N +LL+  Y E +    GK +       + CYYQGHI    
Sbjct: 88  QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145

Query: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
            S  ++STC GL G F  G+  Y IEP        D   H+++K    E + D       
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200

Query: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
                + QQ    P+  ++K +            R V+E  KYIE  +V D+  FK++  
Sbjct: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257

Query: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
           +          + N  +++YK +L T + LV ME W   +K  I+ N   TL  F K+R 
Sbjct: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317

Query: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
             +  +++ D   L + ++   +  G A++  +CS    G V +     L +A T+A  +
Sbjct: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374

Query: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
            HN G+  D        CKC  T   C+M     +Y+P  F+ C+   Y  F       C
Sbjct: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433

Query: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
           LFN P  + ++  P CGN  +E GE+CDCGT  EC      CC  K C +    QC+ G 
Sbjct: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489

Query: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
           CC+KC+F+  G VCR A ++CD+ E C+G S  C  +  +++G+ C   +G C  G C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549

Query: 512 LQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGS 570
              QC  +WG     +DK CY + N  G++ G C +  DT I C   D +CG L C    
Sbjct: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCT-NI 608

Query: 571 DNLPWKGRIVTFLTCKTFDPE-------------DTSQEIGMVANGTKCGDNKVCINAEC 617
            N+P  G +   +T      +             +   ++G V +GT CG   +C+   C
Sbjct: 609 GNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRC 668

Query: 618 VDIEKAYKSTNCSSK----CKGHAVCDHELQCQCEEGWIPPDC-------DDSSV----- 661
           + +     ST  SSK    C G+ VC +EL+C C   WI  DC       DD+       
Sbjct: 669 LPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728

Query: 662 ---VFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPL 702
              V   +I++G++   A   +V+A+++   +   K  ++QR L
Sbjct: 729 GNGVAGTNIIIGII---AGTILVLALILGITAWGYKNYREQRQL 769


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score =  311 bits (798), Expect = 1e-84
 Identities = 207/704 (29%), Positives = 322/704 (45%), Gaps = 79/704 (11%)

Query: 56  ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
           +  +++   G   +L +  N +LL+  Y E +    GK +       + CYYQGHI    
Sbjct: 88  QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145

Query: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
            S  ++STC GL G F  G+  Y IEP        D   H+++K    E + D       
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200

Query: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
                + QQ    P+  ++K +            R V+E  KYIE  +V D+  FK++  
Sbjct: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257

Query: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
           +          + N  +++YK +L T + LV ME W   +K  I+ N   TL  F K+R 
Sbjct: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317

Query: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
             +  +++ D   L + ++   +  G A++  +CS    G V +     L +A T+A  +
Sbjct: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374

Query: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
            HN G+  D        CKC  T   C+M     +Y+P  F+ C+   Y  F       C
Sbjct: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433

Query: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
           LFN P  + ++  P CGN  +E GE+CDCGT  EC      CC  K C +    QC+ G 
Sbjct: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489

Query: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
           CC+KC+F+  G VCR A ++CD+ E C+G S  C  +  +++G+ C   +G C  G C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549

Query: 512 LQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGS 570
              QC  +WG     +DK CY + N  G++ G C +  DT I C   D +CG L C    
Sbjct: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCT-NI 608

Query: 571 DNLPWKGRIVTFLTCKTFDPE-------------DTSQEIGMVANGTKCGDNKVCINAEC 617
            N+P  G +   +T      +             +   ++G V +GT CG   +C+   C
Sbjct: 609 GNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRC 668

Query: 618 VDIEKAYKSTNCSSK----CKGHAVCDHELQCQCEEGWIPPDC-------DDSSV----- 661
           + +     ST  SSK    C G+ VC +EL+C C   WI  DC       DD+       
Sbjct: 669 LPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728

Query: 662 ---VFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPL 702
              V   +I++G++   A   +V+A+++   +   K  ++QR L
Sbjct: 729 GNGVAGTNIIIGII---AGTILVLALILGITAWGYKNYREQRQL 769


>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
           sapiens]
          Length = 735

 Score =  311 bits (797), Expect = 1e-84
 Identities = 199/647 (30%), Positives = 306/647 (47%), Gaps = 36/647 (5%)

Query: 50  QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
           +E  E++  YK+ I GK   + L + KN L   +    Y+ TG          + C+YQG
Sbjct: 38  KEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQG 96

Query: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
           +I     S   +STC GLRG     +  Y IEPL      G EH +  Y    K  D + 
Sbjct: 97  YIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLES--SVGFEHVI--YQVKHKKADVSL 152

Query: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
             +  + + DL       + KL  ++ +  Q+  KYIE +++++   +     +   + +
Sbjct: 153 YNEKDIESRDL-------SFKLQSVEPQ--QDFAKYIEMHVIVEKQLYNHMGSDTTVVAQ 203

Query: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
           +VF++    N ++   N  + L  +E+W D++KI  T  A+  L  F +W+ S L  R  
Sbjct: 204 KVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRP- 262

Query: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVV-QDHSDNLLRVAGTMAHEMGHNFGM 347
           HD+A L+   E +   VG  F   MC   Y+ GVV    + +L  +A  +A  +  + G+
Sbjct: 263 HDVAFLLVYREKSNY-VGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGI 321

Query: 348 FHDDYS-CKCPSTICVMD-KALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAP-LPTDI 404
            +DD + C+C   +C+M+ +A+ F     FS+CS   +  F   + S CL N P L    
Sbjct: 322 TYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFF 381

Query: 405 ISTPICGNQLVEMGEDCDCGTSEECTNI---CCDAKTCKIKATFQCALGECCEKCQFKKA 461
               +CGN  +E GE+CDCGT ++C  I   CCD  TC+ KA   CA G CCE C F   
Sbjct: 382 KQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSK 441

Query: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
             +CRP+ +ECDLPE CNG S +CP++ +   G PC   +  C+ G C +  +QCT+ +G
Sbjct: 442 ERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFG 501

Query: 522 PGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIV 580
              E     CY+  N      G C   D     C+A++  CGKL C+     L    R  
Sbjct: 502 KEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRAT 561

Query: 581 TFLT--------CKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSS- 631
                          F  +    +   + +GT CG NKVC N  CV    +Y   +C++ 
Sbjct: 562 IIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCV--SSSYLGYDCTTD 619

Query: 632 KCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVI 678
           KC    VC+++  C C   ++PPDC   S ++    +    FP   I
Sbjct: 620 KCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAI 666


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  310 bits (795), Expect = 3e-84
 Identities = 206/702 (29%), Positives = 321/702 (45%), Gaps = 79/702 (11%)

Query: 56  ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
           +  +++   G   +L +  N +LL+  Y E +    GK +       + CYYQGHI    
Sbjct: 88  QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145

Query: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
            S  ++STC GL G F  G+  Y IEP        D   H+++K    E + D       
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200

Query: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
                + QQ    P+  ++K +            R V+E  KYIE  +V D+  FK++  
Sbjct: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257

Query: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
           +          + N  +++YK +L T + LV ME W   +K  I+ N   TL  F K+R 
Sbjct: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317

Query: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
             +  +++ D   L + ++   +  G A++  +CS    G V +     L +A T+A  +
Sbjct: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374

Query: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
            HN G+  D        CKC  T   C+M     +Y+P  F+ C+   Y  F       C
Sbjct: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433

Query: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
           LFN P  + ++  P CGN  +E GE+CDCGT  EC      CC  K C +    QC+ G 
Sbjct: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489

Query: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
           CC+KC+F+  G VCR A ++CD+ E C+G S  C  +  +++G+ C   +G C  G C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549

Query: 512 LQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGS 570
              QC  +WG     +DK CY + N  G++ G C +  DT I C   D +CG L C    
Sbjct: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCT-NI 608

Query: 571 DNLPWKGRIVTFLTCKTFDPE-------------DTSQEIGMVANGTKCGDNKVCINAEC 617
            N+P  G +   +T      +             +   ++G V +GT CG   +C+   C
Sbjct: 609 GNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRC 668

Query: 618 VDIEKAYKSTNCSSK----CKGHAVCDHELQCQCEEGWIPPDC-------DDSSV----- 661
           + +     ST  SSK    C G+ VC +EL+C C   WI  DC       DD+       
Sbjct: 669 LPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728

Query: 662 ---VFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQR 700
              V   +I++G++   A   +V+A+++   +   K  ++QR
Sbjct: 729 GNGVAGTNIIIGII---AGTILVLALILGITAWGYKNYREQR 767


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  310 bits (795), Expect = 3e-84
 Identities = 206/702 (29%), Positives = 321/702 (45%), Gaps = 79/702 (11%)

Query: 56  ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
           +  +++   G   +L +  N +LL+  Y E +    GK +       + CYYQGHI    
Sbjct: 88  QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145

Query: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
            S  ++STC GL G F  G+  Y IEP        D   H+++K    E + D       
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200

Query: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
                + QQ    P+  ++K +            R V+E  KYIE  +V D+  FK++  
Sbjct: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257

Query: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
           +          + N  +++YK +L T + LV ME W   +K  I+ N   TL  F K+R 
Sbjct: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317

Query: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
             +  +++ D   L + ++   +  G A++  +CS    G V +     L +A T+A  +
Sbjct: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374

Query: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
            HN G+  D        CKC  T   C+M     +Y+P  F+ C+   Y  F       C
Sbjct: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433

Query: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
           LFN P  + ++  P CGN  +E GE+CDCGT  EC      CC  K C +    QC+ G 
Sbjct: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489

Query: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
           CC+KC+F+  G VCR A ++CD+ E C+G S  C  +  +++G+ C   +G C  G C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549

Query: 512 LQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGS 570
              QC  +WG     +DK CY + N  G++ G C +  DT I C   D +CG L C    
Sbjct: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCT-NI 608

Query: 571 DNLPWKGRIVTFLTCKTFDPE-------------DTSQEIGMVANGTKCGDNKVCINAEC 617
            N+P  G +   +T      +             +   ++G V +GT CG   +C+   C
Sbjct: 609 GNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRC 668

Query: 618 VDIEKAYKSTNCSSK----CKGHAVCDHELQCQCEEGWIPPDC-------DDSSV----- 661
           + +     ST  SSK    C G+ VC +EL+C C   WI  DC       DD+       
Sbjct: 669 LPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728

Query: 662 ---VFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQR 700
              V   +I++G++   A   +V+A+++   +   K  ++QR
Sbjct: 729 GNGVAGTNIIIGII---AGTILVLALILGITAWGYKNYREQR 767


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  310 bits (795), Expect = 3e-84
 Identities = 206/702 (29%), Positives = 321/702 (45%), Gaps = 79/702 (11%)

Query: 56  ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
           +  +++   G   +L +  N +LL+  Y E +    GK +       + CYYQGHI    
Sbjct: 88  QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145

Query: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
            S  ++STC GL G F  G+  Y IEP        D   H+++K    E + D       
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200

Query: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
                + QQ    P+  ++K +            R V+E  KYIE  +V D+  FK++  
Sbjct: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257

Query: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
           +          + N  +++YK +L T + LV ME W   +K  I+ N   TL  F K+R 
Sbjct: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317

Query: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
             +  +++ D   L + ++   +  G A++  +CS    G V +     L +A T+A  +
Sbjct: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374

Query: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
            HN G+  D        CKC  T   C+M     +Y+P  F+ C+   Y  F       C
Sbjct: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433

Query: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
           LFN P  + ++  P CGN  +E GE+CDCGT  EC      CC  K C +    QC+ G 
Sbjct: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489

Query: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
           CC+KC+F+  G VCR A ++CD+ E C+G S  C  +  +++G+ C   +G C  G C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549

Query: 512 LQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGS 570
              QC  +WG     +DK CY + N  G++ G C +  DT I C   D +CG L C    
Sbjct: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCT-NI 608

Query: 571 DNLPWKGRIVTFLTCKTFDPE-------------DTSQEIGMVANGTKCGDNKVCINAEC 617
            N+P  G +   +T      +             +   ++G V +GT CG   +C+   C
Sbjct: 609 GNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRC 668

Query: 618 VDIEKAYKSTNCSSK----CKGHAVCDHELQCQCEEGWIPPDC-------DDSSV----- 661
           + +     ST  SSK    C G+ VC +EL+C C   WI  DC       DD+       
Sbjct: 669 LPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728

Query: 662 ---VFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQR 700
              V   +I++G++   A   +V+A+++   +   K  ++QR
Sbjct: 729 GNGVAGTNIIIGII---AGTILVLALILGITAWGYKNYREQR 767


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  309 bits (792), Expect = 6e-84
 Identities = 207/755 (27%), Positives = 343/755 (45%), Gaps = 65/755 (8%)

Query: 57  LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116
           L Y +   G+  ++++K  K L +       Y   G  +   P + ++CYY G++  +  
Sbjct: 52  LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111

Query: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167
           S  S+STC  G +G     D  Y I+PL+       EH ++K + +EK + +        
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169

Query: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225
             TC M+     +  Q+  +     +          H + +E  +V+DN  + RY  N  
Sbjct: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219

Query: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285
           ++ + ++ + N V+ +   +   V L G+EIWT+K+ I +  +   ++  + KW+   ++
Sbjct: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278

Query: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344
            R +HD + L T   L G + G+     MC+P+ S  +V   +  L   +  +AH +GHN
Sbjct: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337

Query: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402
            GM HD+ +C+C    C+M +       T FS+CS   Y  F+E  +  + CL       
Sbjct: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462
           DI +   CGN +VE GE+CDCG  + C    C    C +     CA G CC+ C+F  +G
Sbjct: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452

Query: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522
            VCR   +ECDLPE CNG S  CPDD +  +G PC   +G+C   +C    EQC  ++G 
Sbjct: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511

Query: 523 GTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQ------GGSDNLPW 575
           G   A ++CY   N  G + G+C   + T I C  +D  CG++ C+        SD+   
Sbjct: 512 GANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV 571

Query: 576 KGRIVTFLTCKTFDPE--DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCS-SK 632
                  + C + D        +IG V +GT+CG + +CI+  CV I     ++NCS + 
Sbjct: 572 HWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAF 629

Query: 633 CKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVG--------------VLFPMAVI 678
           C    +C+++  C C   W PP+C      +  S+  G               +  + V+
Sbjct: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKG--YGGSVDSGPPPKRKKKKKFCYLCILLLIVL 687

Query: 679 FVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLP 738
           F+++  + R     +  KK Q   + +     K +R+P     + PQ    + P     P
Sbjct: 688 FILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPH---ELPPQSQPWVMPSQSQPP 744

Query: 739 VEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNP 773
           V  ++         +  P T  +  P   P  S P
Sbjct: 745 VTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQP 779


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  309 bits (792), Expect = 6e-84
 Identities = 207/755 (27%), Positives = 343/755 (45%), Gaps = 65/755 (8%)

Query: 57  LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116
           L Y +   G+  ++++K  K L +       Y   G  +   P + ++CYY G++  +  
Sbjct: 52  LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111

Query: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167
           S  S+STC  G +G     D  Y I+PL+       EH ++K + +EK + +        
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169

Query: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225
             TC M+     +  Q+  +     +          H + +E  +V+DN  + RY  N  
Sbjct: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219

Query: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285
           ++ + ++ + N V+ +   +   V L G+EIWT+K+ I +  +   ++  + KW+   ++
Sbjct: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278

Query: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344
            R +HD + L T   L G + G+     MC+P+ S  +V   +  L   +  +AH +GHN
Sbjct: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337

Query: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402
            GM HD+ +C+C    C+M +       T FS+CS   Y  F+E  +  + CL       
Sbjct: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462
           DI +   CGN +VE GE+CDCG  + C    C    C +     CA G CC+ C+F  +G
Sbjct: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452

Query: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522
            VCR   +ECDLPE CNG S  CPDD +  +G PC   +G+C   +C    EQC  ++G 
Sbjct: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511

Query: 523 GTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQ------GGSDNLPW 575
           G   A ++CY   N  G + G+C   + T I C  +D  CG++ C+        SD+   
Sbjct: 512 GANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV 571

Query: 576 KGRIVTFLTCKTFDPE--DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCS-SK 632
                  + C + D        +IG V +GT+CG + +CI+  CV I     ++NCS + 
Sbjct: 572 HWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAF 629

Query: 633 CKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVG--------------VLFPMAVI 678
           C    +C+++  C C   W PP+C      +  S+  G               +  + V+
Sbjct: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKG--YGGSVDSGPPPKRKKKKKFCYLCILLLIVL 687

Query: 679 FVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLP 738
           F+++  + R     +  KK Q   + +     K +R+P     + PQ    + P     P
Sbjct: 688 FILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPH---ELPPQSQPWVMPSQSQPP 744

Query: 739 VEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNP 773
           V  ++         +  P T  +  P   P  S P
Sbjct: 745 VTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQP 779


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  309 bits (792), Expect = 6e-84
 Identities = 207/755 (27%), Positives = 343/755 (45%), Gaps = 65/755 (8%)

Query: 57  LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116
           L Y +   G+  ++++K  K L +       Y   G  +   P + ++CYY G++  +  
Sbjct: 52  LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111

Query: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167
           S  S+STC  G +G     D  Y I+PL+       EH ++K + +EK + +        
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169

Query: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225
             TC M+     +  Q+  +     +          H + +E  +V+DN  + RY  N  
Sbjct: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219

Query: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285
           ++ + ++ + N V+ +   +   V L G+EIWT+K+ I +  +   ++  + KW+   ++
Sbjct: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278

Query: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344
            R +HD + L T   L G + G+     MC+P+ S  +V   +  L   +  +AH +GHN
Sbjct: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337

Query: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402
            GM HD+ +C+C    C+M +       T FS+CS   Y  F+E  +  + CL       
Sbjct: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462
           DI +   CGN +VE GE+CDCG  + C    C    C +     CA G CC+ C+F  +G
Sbjct: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452

Query: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522
            VCR   +ECDLPE CNG S  CPDD +  +G PC   +G+C   +C    EQC  ++G 
Sbjct: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511

Query: 523 GTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQ------GGSDNLPW 575
           G   A ++CY   N  G + G+C   + T I C  +D  CG++ C+        SD+   
Sbjct: 512 GANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV 571

Query: 576 KGRIVTFLTCKTFDPE--DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCS-SK 632
                  + C + D        +IG V +GT+CG + +CI+  CV I     ++NCS + 
Sbjct: 572 HWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAF 629

Query: 633 CKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVG--------------VLFPMAVI 678
           C    +C+++  C C   W PP+C      +  S+  G               +  + V+
Sbjct: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKG--YGGSVDSGPPPKRKKKKKFCYLCILLLIVL 687

Query: 679 FVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLP 738
           F+++  + R     +  KK Q   + +     K +R+P     + PQ    + P     P
Sbjct: 688 FILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPH---ELPPQSQPWVMPSQSQPP 744

Query: 739 VEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNP 773
           V  ++         +  P T  +  P   P  S P
Sbjct: 745 VTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQP 779


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  309 bits (792), Expect = 6e-84
 Identities = 207/755 (27%), Positives = 343/755 (45%), Gaps = 65/755 (8%)

Query: 57  LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKV 116
           L Y +   G+  ++++K  K L +       Y   G  +   P + ++CYY G++  +  
Sbjct: 52  LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111

Query: 117 SDASISTC-RGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDS-------- 167
           S  S+STC  G +G     D  Y I+PL+       EH ++K + +EK + +        
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLA--FSTTFEHLVYKMDSEEKQFSTMRSGFMQN 169

Query: 168 --TCGMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQD 225
             TC M+     +  Q+  +     +          H + +E  +V+DN  + RY  N  
Sbjct: 170 EITCRMEFEEIDNSTQKQSSYVGWWI----------HFRIVEIVVVIDNYLYIRYERNDS 219

Query: 226 EIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLS 285
           ++ + ++ + N V+ +   +   V L G+EIWT+K+ I +  +   ++  + KW+   ++
Sbjct: 220 KLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENIT 278

Query: 286 RRKRHDIAQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHN 344
            R +HD + L T   L G + G+     MC+P+ S  +V   +  L   +  +AH +GHN
Sbjct: 279 PRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHN 337

Query: 345 FGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKL--SNCLFNAPLPT 402
            GM HD+ +C+C    C+M +       T FS+CS   Y  F+E  +  + CL       
Sbjct: 338 LGMNHDEDTCRCSQPRCIMHEGNPPI--TKFSNCS---YGDFWEYTVERTKCLLETVHTK 392

Query: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAG 462
           DI +   CGN +VE GE+CDCG  + C    C    C +     CA G CC+ C+F  +G
Sbjct: 393 DIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSG 452

Query: 463 MVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGP 522
            VCR   +ECDLPE CNG S  CPDD +  +G PC   +G+C   +C    EQC  ++G 
Sbjct: 453 KVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCKE-RGYCYEKSCHDRNEQCRRIFGA 511

Query: 523 GTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQ------GGSDNLPW 575
           G   A ++CY   N  G + G+C   + T I C  +D  CG++ C+        SD+   
Sbjct: 512 GANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV 571

Query: 576 KGRIVTFLTCKTFDPE--DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCS-SK 632
                  + C + D        +IG V +GT+CG + +CI+  CV I     ++NCS + 
Sbjct: 572 HWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAF 629

Query: 633 CKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVG--------------VLFPMAVI 678
           C    +C+++  C C   W PP+C      +  S+  G               +  + V+
Sbjct: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKG--YGGSVDSGPPPKRKKKKKFCYLCILLLIVL 687

Query: 679 FVVVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLP 738
           F+++  + R     +  KK Q   + +     K +R+P     + PQ    + P     P
Sbjct: 688 FILLCCLYRLCKKSKPIKKQQDVQTPSAKEEEKIQRRPH---ELPPQSQPWVMPSQSQPP 744

Query: 739 VEGNEPPASFHKDTNALPPTVFKDNPVSTPKDSNP 773
           V  ++         +  P T  +  P   P  S P
Sbjct: 745 VTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQP 779


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,950,986
Number of Sequences: 37866
Number of extensions: 1614871
Number of successful extensions: 5227
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 148
Number of HSP's that attempted gapping in prelim test: 4356
Number of HSP's gapped (non-prelim): 666
length of query: 775
length of database: 18,247,518
effective HSP length: 110
effective length of query: 665
effective length of database: 14,082,258
effective search space: 9364701570
effective search space used: 9364701570
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.