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Search of human proteins with 90403592
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90403592 phosphate-regulating neutral endopeptidase [Homo
sapiens]
(749 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90403592 phosphate-regulating neutral endopeptidase [Homo sap... 1529 0.0
gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens] 505 e-143
gi|116256333 membrane metallo-endopeptidase [Homo sapiens] 480 e-135
gi|116256331 membrane metallo-endopeptidase [Homo sapiens] 480 e-135
gi|116256327 membrane metallo-endopeptidase [Homo sapiens] 480 e-135
gi|116256329 membrane metallo-endopeptidase [Homo sapiens] 480 e-135
gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo sapi... 472 e-133
gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo sapi... 472 e-133
gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo sapi... 472 e-133
gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens] 472 e-133
gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens] 461 e-129
gi|153945836 endothelin converting enzyme 2 isoform E [Homo sapi... 459 e-129
gi|153945771 endothelin converting enzyme 2 isoform D [Homo sapi... 459 e-129
gi|153945761 endothelin converting enzyme 2 isoform A [Homo sapi... 459 e-129
gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens] 374 e-103
gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens] 209 1e-53
gi|223671856 coiled-coil domain containing 85C [Homo sapiens] 32 2.2
gi|212549782 caspase 8 associated protein 2 [Homo sapiens] 32 2.8
gi|6912288 caspase 8 associated protein 2 [Homo sapiens] 32 2.8
gi|212549532 caspase 8 associated protein 2 [Homo sapiens] 32 2.8
gi|221136806 zinc finger, CCHC domain containing 18 [Homo sapiens] 31 4.8
gi|115495445 ankyrin repeat domain 30A [Homo sapiens] 30 6.3
>gi|90403592 phosphate-regulating neutral endopeptidase [Homo
sapiens]
Length = 749
Score = 1529 bits (3960), Expect = 0.0
Identities = 749/749 (100%), Positives = 749/749 (100%)
Query: 1 MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECI 60
MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECI
Sbjct: 1 MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECI 60
Query: 61 EAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLE 120
EAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLE
Sbjct: 61 EAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLE 120
Query: 121 KSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVW 180
KSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVW
Sbjct: 121 KSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVW 180
Query: 181 SERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNST 240
SERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNST
Sbjct: 181 SERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNST 240
Query: 241 EAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKM 300
EAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKM
Sbjct: 241 EAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKM 300
Query: 301 NISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKK 360
NISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKK
Sbjct: 301 NISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKK 360
Query: 361 TIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGK 420
TIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGK
Sbjct: 361 TIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGK 420
Query: 421 MFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPE 480
MFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPE
Sbjct: 421 MFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPE 480
Query: 481 FIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAF 540
FIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAF
Sbjct: 481 FIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAF 540
Query: 541 YSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLD 600
YSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLD
Sbjct: 541 YSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLD 600
Query: 601 PWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKW 660
PWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKW
Sbjct: 601 PWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKW 660
Query: 661 INDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGA 720
INDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGA
Sbjct: 661 INDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGA 720
Query: 721 ISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749
ISNFEEFQKAFNCPPNSTMNRGMDSCRLW
Sbjct: 721 ISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749
>gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens]
Length = 779
Score = 505 bits (1301), Expect = e-143
Identities = 284/723 (39%), Positives = 427/723 (59%), Gaps = 35/723 (4%)
Query: 42 QGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSY 101
+G+ Q E C P C+ AAA IL ++ + +PCD+F++FAC GW+ + IPE Y
Sbjct: 77 RGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRY 136
Query: 102 GVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILR 161
++ LR +++ LK +LE S ++ D A++KA+ LY SCMN+ IEK ++PLL IL
Sbjct: 137 SIFDVLRDELEVILKAVLENSTAK--DRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILE 194
Query: 162 HSPFRWPVLESNIGPEGVWSER---KFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEH 218
WPV W+E ++ L + LA Q++ V I L++ DD+ S+ H
Sbjct: 195 VVG-GWPVAMDR------WNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRH 247
Query: 219 ILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLL--GANSSR----AEHDMK 272
I+ +DQ TL + RE Y + + K R+A +FMV A LL AN R + DM
Sbjct: 248 IIYIDQPTLGMPSREYYFNGGSNRK-VREAYLQFMVSVATLLREDANLPRDSCLVQEDMV 306
Query: 273 SVLRLEIKIAEIMIPHENRTSE-AMYNKMNISELSAM--IPQFDWLGYIKKVIDTRLYPH 329
VL LE ++A+ +P E R A+Y++M + EL + + F+W +I+ V+ +
Sbjct: 307 QVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKL 366
Query: 330 LKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEF 389
L P E VVV Y ++L I+ + +TI NYLVWR+V RI +LS+RF+ + +
Sbjct: 367 L----PDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNY 422
Query: 390 SRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDM 449
+ + GT +W +CV ++ S + VG ++V F D K M+ EL++ VR F++
Sbjct: 423 RKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVET 482
Query: 450 LEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTH--VNEDLKAIKFSEADYFGNVL 507
L+ E WMD +K+KA+EKA ++ ++G+P++I+ + + ++E+ + FSE YF N L
Sbjct: 483 LD-ELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSL 541
Query: 508 QTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPR 567
Q K AQ LR+ V W VNAFYS + NQI FPAG LQ PFF E P+
Sbjct: 542 QNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFF-SKEQPQ 600
Query: 568 SLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627
+L++G IG+++GHE THGFD+NGR +DKNGN+ WWS S + F+E+++CMI QY NY W
Sbjct: 601 ALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSW 660
Query: 628 KKAG-LNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFL 686
A NV G TLGENIADNGG+R+A++AY KW+ +G ++ LPG+ T+ QLFF+
Sbjct: 661 DLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWM---AEGGKDQQLPGLDLTHEQLFFI 717
Query: 687 SYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSC 746
+YA V C SYRPE A + ++ HSP ++RV G++ N F F+C + M+ + C
Sbjct: 718 NYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMH-PKERC 776
Query: 747 RLW 749
R+W
Sbjct: 777 RVW 779
>gi|116256333 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 480 bits (1236), Expect = e-135
Identities = 265/738 (35%), Positives = 417/738 (56%), Gaps = 40/738 (5%)
Query: 32 VLGTILFLVSQGLLSLQAKQE--YCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWI 89
VL +L +++ +++L A + C +CI++AA ++ ++ + +PC +FF++AC GW+
Sbjct: 33 VLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWL 92
Query: 90 SNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIE 149
N IPE YG + LR +++ LK++L++ + D A+QKAK LY SC+NE AI+
Sbjct: 93 KRNVIPETSSRYGNFDILRDELEVVLKDVLQEP--KTEDIVAVQKAKALYRSCINESAID 150
Query: 150 KADAKPLLHILRHSPFRWPVLESNIGPEGVWSER---KFSLLQTLATFRGQYSNSVFIRL 206
+PLL +L + WPV N W ++ ++ + +A +Y V I L
Sbjct: 151 SRGGEPLLKLLPDI-YGWPVATEN------WEQKYGASWTAEKAIAQLNSKYGKKVLINL 203
Query: 207 YVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVL------L 260
+V DDK S H++ +DQ L L R DY + + K A FM+ A L L
Sbjct: 204 FVGTDDKNSVNHVIHIDQPRLGLPSR-DYYECTGIYKEACTAYVDFMISVARLIRQEERL 262
Query: 261 GANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIP------QFD 313
+ ++ +M V+ LE +IA E+R + YNKM ++++ F
Sbjct: 263 PIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFS 322
Query: 314 WLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYS 373
WL + +++ T I+ E+VVV P+Y L IL + + N + WR +
Sbjct: 323 WLNFTNEIMSTVNI----SITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
Query: 374 RIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKE 433
+ +LSR ++ F + + GTT+ W +C N++ + VG+++V+ F + K
Sbjct: 379 LVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKH 438
Query: 434 MMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIM-NDTHVNEDL 492
++E+L+ +R FI L+ + WMDA TK++A+EKA A+ ++GYP+ I+ ND +N +
Sbjct: 439 VVEDLIAQIREVFIQTLD-DLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
Query: 493 KAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPA 552
+ + E +YF N++Q K+ LR+ V K EW + VNAFYS+ NQI FPA
Sbjct: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
Query: 553 GELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFK 612
G LQ PFF + SL+YG IG+++GHE THGFD+NGR ++K+G+L WW+ +S FK
Sbjct: 558 GILQPPFF-SAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFK 616
Query: 613 EKTKCMINQYSNYYWKKA-GLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEP 671
E+++CM+ QY N+ W A G ++ G TLGENIADNGGL +A+RAY+ +I ++ EE
Sbjct: 617 EQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYI---KKNGEEK 673
Query: 672 LLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAF 731
LLPG+ + QLFFL++A V C +YRPE A ++ HSP FR+ G + N EF +AF
Sbjct: 674 LLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAF 733
Query: 732 NCPPNSTMNRGMDSCRLW 749
+C NS MN CR+W
Sbjct: 734 HCRKNSYMN-PEKKCRVW 750
>gi|116256331 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 480 bits (1236), Expect = e-135
Identities = 265/738 (35%), Positives = 417/738 (56%), Gaps = 40/738 (5%)
Query: 32 VLGTILFLVSQGLLSLQAKQE--YCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWI 89
VL +L +++ +++L A + C +CI++AA ++ ++ + +PC +FF++AC GW+
Sbjct: 33 VLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWL 92
Query: 90 SNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIE 149
N IPE YG + LR +++ LK++L++ + D A+QKAK LY SC+NE AI+
Sbjct: 93 KRNVIPETSSRYGNFDILRDELEVVLKDVLQEP--KTEDIVAVQKAKALYRSCINESAID 150
Query: 150 KADAKPLLHILRHSPFRWPVLESNIGPEGVWSER---KFSLLQTLATFRGQYSNSVFIRL 206
+PLL +L + WPV N W ++ ++ + +A +Y V I L
Sbjct: 151 SRGGEPLLKLLPDI-YGWPVATEN------WEQKYGASWTAEKAIAQLNSKYGKKVLINL 203
Query: 207 YVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVL------L 260
+V DDK S H++ +DQ L L R DY + + K A FM+ A L L
Sbjct: 204 FVGTDDKNSVNHVIHIDQPRLGLPSR-DYYECTGIYKEACTAYVDFMISVARLIRQEERL 262
Query: 261 GANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIP------QFD 313
+ ++ +M V+ LE +IA E+R + YNKM ++++ F
Sbjct: 263 PIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFS 322
Query: 314 WLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYS 373
WL + +++ T I+ E+VVV P+Y L IL + + N + WR +
Sbjct: 323 WLNFTNEIMSTVNI----SITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
Query: 374 RIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKE 433
+ +LSR ++ F + + GTT+ W +C N++ + VG+++V+ F + K
Sbjct: 379 LVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKH 438
Query: 434 MMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIM-NDTHVNEDL 492
++E+L+ +R FI L+ + WMDA TK++A+EKA A+ ++GYP+ I+ ND +N +
Sbjct: 439 VVEDLIAQIREVFIQTLD-DLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
Query: 493 KAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPA 552
+ + E +YF N++Q K+ LR+ V K EW + VNAFYS+ NQI FPA
Sbjct: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
Query: 553 GELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFK 612
G LQ PFF + SL+YG IG+++GHE THGFD+NGR ++K+G+L WW+ +S FK
Sbjct: 558 GILQPPFF-SAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFK 616
Query: 613 EKTKCMINQYSNYYWKKA-GLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEP 671
E+++CM+ QY N+ W A G ++ G TLGENIADNGGL +A+RAY+ +I ++ EE
Sbjct: 617 EQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYI---KKNGEEK 673
Query: 672 LLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAF 731
LLPG+ + QLFFL++A V C +YRPE A ++ HSP FR+ G + N EF +AF
Sbjct: 674 LLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAF 733
Query: 732 NCPPNSTMNRGMDSCRLW 749
+C NS MN CR+W
Sbjct: 734 HCRKNSYMN-PEKKCRVW 750
>gi|116256327 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 480 bits (1236), Expect = e-135
Identities = 265/738 (35%), Positives = 417/738 (56%), Gaps = 40/738 (5%)
Query: 32 VLGTILFLVSQGLLSLQAKQE--YCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWI 89
VL +L +++ +++L A + C +CI++AA ++ ++ + +PC +FF++AC GW+
Sbjct: 33 VLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWL 92
Query: 90 SNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIE 149
N IPE YG + LR +++ LK++L++ + D A+QKAK LY SC+NE AI+
Sbjct: 93 KRNVIPETSSRYGNFDILRDELEVVLKDVLQEP--KTEDIVAVQKAKALYRSCINESAID 150
Query: 150 KADAKPLLHILRHSPFRWPVLESNIGPEGVWSER---KFSLLQTLATFRGQYSNSVFIRL 206
+PLL +L + WPV N W ++ ++ + +A +Y V I L
Sbjct: 151 SRGGEPLLKLLPDI-YGWPVATEN------WEQKYGASWTAEKAIAQLNSKYGKKVLINL 203
Query: 207 YVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVL------L 260
+V DDK S H++ +DQ L L R DY + + K A FM+ A L L
Sbjct: 204 FVGTDDKNSVNHVIHIDQPRLGLPSR-DYYECTGIYKEACTAYVDFMISVARLIRQEERL 262
Query: 261 GANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIP------QFD 313
+ ++ +M V+ LE +IA E+R + YNKM ++++ F
Sbjct: 263 PIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFS 322
Query: 314 WLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYS 373
WL + +++ T I+ E+VVV P+Y L IL + + N + WR +
Sbjct: 323 WLNFTNEIMSTVNI----SITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
Query: 374 RIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKE 433
+ +LSR ++ F + + GTT+ W +C N++ + VG+++V+ F + K
Sbjct: 379 LVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKH 438
Query: 434 MMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIM-NDTHVNEDL 492
++E+L+ +R FI L+ + WMDA TK++A+EKA A+ ++GYP+ I+ ND +N +
Sbjct: 439 VVEDLIAQIREVFIQTLD-DLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
Query: 493 KAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPA 552
+ + E +YF N++Q K+ LR+ V K EW + VNAFYS+ NQI FPA
Sbjct: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
Query: 553 GELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFK 612
G LQ PFF + SL+YG IG+++GHE THGFD+NGR ++K+G+L WW+ +S FK
Sbjct: 558 GILQPPFF-SAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFK 616
Query: 613 EKTKCMINQYSNYYWKKA-GLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEP 671
E+++CM+ QY N+ W A G ++ G TLGENIADNGGL +A+RAY+ +I ++ EE
Sbjct: 617 EQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYI---KKNGEEK 673
Query: 672 LLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAF 731
LLPG+ + QLFFL++A V C +YRPE A ++ HSP FR+ G + N EF +AF
Sbjct: 674 LLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAF 733
Query: 732 NCPPNSTMNRGMDSCRLW 749
+C NS MN CR+W
Sbjct: 734 HCRKNSYMN-PEKKCRVW 750
>gi|116256329 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 480 bits (1236), Expect = e-135
Identities = 265/738 (35%), Positives = 417/738 (56%), Gaps = 40/738 (5%)
Query: 32 VLGTILFLVSQGLLSLQAKQE--YCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWI 89
VL +L +++ +++L A + C +CI++AA ++ ++ + +PC +FF++AC GW+
Sbjct: 33 VLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWL 92
Query: 90 SNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIE 149
N IPE YG + LR +++ LK++L++ + D A+QKAK LY SC+NE AI+
Sbjct: 93 KRNVIPETSSRYGNFDILRDELEVVLKDVLQEP--KTEDIVAVQKAKALYRSCINESAID 150
Query: 150 KADAKPLLHILRHSPFRWPVLESNIGPEGVWSER---KFSLLQTLATFRGQYSNSVFIRL 206
+PLL +L + WPV N W ++ ++ + +A +Y V I L
Sbjct: 151 SRGGEPLLKLLPDI-YGWPVATEN------WEQKYGASWTAEKAIAQLNSKYGKKVLINL 203
Query: 207 YVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVL------L 260
+V DDK S H++ +DQ L L R DY + + K A FM+ A L L
Sbjct: 204 FVGTDDKNSVNHVIHIDQPRLGLPSR-DYYECTGIYKEACTAYVDFMISVARLIRQEERL 262
Query: 261 GANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIP------QFD 313
+ ++ +M V+ LE +IA E+R + YNKM ++++ F
Sbjct: 263 PIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFS 322
Query: 314 WLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYS 373
WL + +++ T I+ E+VVV P+Y L IL + + N + WR +
Sbjct: 323 WLNFTNEIMSTVNI----SITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMD 378
Query: 374 RIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKE 433
+ +LSR ++ F + + GTT+ W +C N++ + VG+++V+ F + K
Sbjct: 379 LVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKH 438
Query: 434 MMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIM-NDTHVNEDL 492
++E+L+ +R FI L+ + WMDA TK++A+EKA A+ ++GYP+ I+ ND +N +
Sbjct: 439 VVEDLIAQIREVFIQTLD-DLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497
Query: 493 KAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPA 552
+ + E +YF N++Q K+ LR+ V K EW + VNAFYS+ NQI FPA
Sbjct: 498 LELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557
Query: 553 GELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFK 612
G LQ PFF + SL+YG IG+++GHE THGFD+NGR ++K+G+L WW+ +S FK
Sbjct: 558 GILQPPFF-SAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFK 616
Query: 613 EKTKCMINQYSNYYWKKA-GLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEP 671
E+++CM+ QY N+ W A G ++ G TLGENIADNGGL +A+RAY+ +I ++ EE
Sbjct: 617 EQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYI---KKNGEEK 673
Query: 672 LLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAF 731
LLPG+ + QLFFL++A V C +YRPE A ++ HSP FR+ G + N EF +AF
Sbjct: 674 LLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAF 733
Query: 732 NCPPNSTMNRGMDSCRLW 749
+C NS MN CR+W
Sbjct: 734 HCRKNSYMN-PEKKCRVW 750
>gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo
sapiens]
Length = 767
Score = 472 bits (1214), Expect = e-133
Identities = 271/722 (37%), Positives = 401/722 (55%), Gaps = 30/722 (4%)
Query: 31 LVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWIS 90
L G + L + G+ CL C+ ++ILS ++ +VDPC +FF +AC GWI
Sbjct: 73 LAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIK 132
Query: 91 NNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEK 150
NP+P+ +G + L + +K LLE S + +EA +KA++ Y +CMNE IE+
Sbjct: 133 ANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASV--SEAERKAQVYYRACMNETRIEE 190
Query: 151 ADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSP 210
AKPL+ ++ W + G W++ F TL Y S F +YVS
Sbjct: 191 LRAKPLMELIERLG-GWNIT-------GPWAKDNFQ--DTLQVVTAHYRTSPFFSVYVSA 240
Query: 211 DDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRA-EH 269
D K SN +++++DQ+ L L R+ YL N TE + +MV LLG A
Sbjct: 241 DSKNSNSNVIQVDQSGLGLPSRDYYL-NKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRP 299
Query: 270 DMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIPQFDWLGYIKKVIDTRLYP 328
M+ +L E +A I IP E R E + Y+K+ +EL + P +WL ++ +T YP
Sbjct: 300 QMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL----NTIFYP 355
Query: 329 HLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLE 388
+I+ SE +VV +Y + + ++ + + + NY++W +V L +RFQ +
Sbjct: 356 --VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEK 413
Query: 389 FSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFI 447
F V+ GT T LP+W CV+ E+ L + +G MFV F ED K + E++ ++ AF
Sbjct: 414 FMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFE 473
Query: 448 DMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVL 507
+ L +WMD T++ AKEKA A+ +GYP FIM+ +++ YF N +
Sbjct: 474 ESLSTL-KWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAM 532
Query: 508 QTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPR 567
+ + + LRKA + +W P VNA+YS + N+I FPAG LQ PF+ + P+
Sbjct: 533 RFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSS-PK 591
Query: 568 SLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627
+L++G IGV+VGHE TH FD+ GR+YDK+GNL PWW S E FK +T+CM+ QYSNY
Sbjct: 592 ALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNY-- 649
Query: 628 KKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLS 687
G V G+ TLGENIADNGGL+ A+RAY+ W+ ++ G E LP + TNNQLFFL
Sbjct: 650 SVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWV--KKNGAEHS-LPTLGLTNNQLFFLG 706
Query: 688 YAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCR 747
+A V C+ PE++ E + HSP +FRV G++SN +EF + F CPP S MN C
Sbjct: 707 FAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMN-PPHKCE 765
Query: 748 LW 749
+W
Sbjct: 766 VW 767
>gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo
sapiens]
Length = 754
Score = 472 bits (1214), Expect = e-133
Identities = 271/722 (37%), Positives = 401/722 (55%), Gaps = 30/722 (4%)
Query: 31 LVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWIS 90
L G + L + G+ CL C+ ++ILS ++ +VDPC +FF +AC GWI
Sbjct: 60 LAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIK 119
Query: 91 NNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEK 150
NP+P+ +G + L + +K LLE S + +EA +KA++ Y +CMNE IE+
Sbjct: 120 ANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASV--SEAERKAQVYYRACMNETRIEE 177
Query: 151 ADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSP 210
AKPL+ ++ W + G W++ F TL Y S F +YVS
Sbjct: 178 LRAKPLMELIERLG-GWNIT-------GPWAKDNFQ--DTLQVVTAHYRTSPFFSVYVSA 227
Query: 211 DDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRA-EH 269
D K SN +++++DQ+ L L R+ YL N TE + +MV LLG A
Sbjct: 228 DSKNSNSNVIQVDQSGLGLPSRDYYL-NKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRP 286
Query: 270 DMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIPQFDWLGYIKKVIDTRLYP 328
M+ +L E +A I IP E R E + Y+K+ +EL + P +WL ++ +T YP
Sbjct: 287 QMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL----NTIFYP 342
Query: 329 HLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLE 388
+I+ SE +VV +Y + + ++ + + + NY++W +V L +RFQ +
Sbjct: 343 --VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEK 400
Query: 389 FSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFI 447
F V+ GT T LP+W CV+ E+ L + +G MFV F ED K + E++ ++ AF
Sbjct: 401 FMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFE 460
Query: 448 DMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVL 507
+ L +WMD T++ AKEKA A+ +GYP FIM+ +++ YF N +
Sbjct: 461 ESLSTL-KWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAM 519
Query: 508 QTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPR 567
+ + + LRKA + +W P VNA+YS + N+I FPAG LQ PF+ + P+
Sbjct: 520 RFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSS-PK 578
Query: 568 SLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627
+L++G IGV+VGHE TH FD+ GR+YDK+GNL PWW S E FK +T+CM+ QYSNY
Sbjct: 579 ALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNY-- 636
Query: 628 KKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLS 687
G V G+ TLGENIADNGGL+ A+RAY+ W+ ++ G E LP + TNNQLFFL
Sbjct: 637 SVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWV--KKNGAEHS-LPTLGLTNNQLFFLG 693
Query: 688 YAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCR 747
+A V C+ PE++ E + HSP +FRV G++SN +EF + F CPP S MN C
Sbjct: 694 FAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMN-PPHKCE 752
Query: 748 LW 749
+W
Sbjct: 753 VW 754
>gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo
sapiens]
Length = 758
Score = 472 bits (1214), Expect = e-133
Identities = 271/722 (37%), Positives = 401/722 (55%), Gaps = 30/722 (4%)
Query: 31 LVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWIS 90
L G + L + G+ CL C+ ++ILS ++ +VDPC +FF +AC GWI
Sbjct: 64 LAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIK 123
Query: 91 NNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEK 150
NP+P+ +G + L + +K LLE S + +EA +KA++ Y +CMNE IE+
Sbjct: 124 ANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASV--SEAERKAQVYYRACMNETRIEE 181
Query: 151 ADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSP 210
AKPL+ ++ W + G W++ F TL Y S F +YVS
Sbjct: 182 LRAKPLMELIERLG-GWNIT-------GPWAKDNFQ--DTLQVVTAHYRTSPFFSVYVSA 231
Query: 211 DDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRA-EH 269
D K SN +++++DQ+ L L R+ YL N TE + +MV LLG A
Sbjct: 232 DSKNSNSNVIQVDQSGLGLPSRDYYL-NKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRP 290
Query: 270 DMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIPQFDWLGYIKKVIDTRLYP 328
M+ +L E +A I IP E R E + Y+K+ +EL + P +WL ++ +T YP
Sbjct: 291 QMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL----NTIFYP 346
Query: 329 HLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLE 388
+I+ SE +VV +Y + + ++ + + + NY++W +V L +RFQ +
Sbjct: 347 --VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEK 404
Query: 389 FSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFI 447
F V+ GT T LP+W CV+ E+ L + +G MFV F ED K + E++ ++ AF
Sbjct: 405 FMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFE 464
Query: 448 DMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVL 507
+ L +WMD T++ AKEKA A+ +GYP FIM+ +++ YF N +
Sbjct: 465 ESLSTL-KWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAM 523
Query: 508 QTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPR 567
+ + + LRKA + +W P VNA+YS + N+I FPAG LQ PF+ + P+
Sbjct: 524 RFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSS-PK 582
Query: 568 SLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627
+L++G IGV+VGHE TH FD+ GR+YDK+GNL PWW S E FK +T+CM+ QYSNY
Sbjct: 583 ALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNY-- 640
Query: 628 KKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLS 687
G V G+ TLGENIADNGGL+ A+RAY+ W+ ++ G E LP + TNNQLFFL
Sbjct: 641 SVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWV--KKNGAEHS-LPTLGLTNNQLFFLG 697
Query: 688 YAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCR 747
+A V C+ PE++ E + HSP +FRV G++SN +EF + F CPP S MN C
Sbjct: 698 FAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMN-PPHKCE 756
Query: 748 LW 749
+W
Sbjct: 757 VW 758
>gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens]
Length = 770
Score = 472 bits (1214), Expect = e-133
Identities = 271/722 (37%), Positives = 401/722 (55%), Gaps = 30/722 (4%)
Query: 31 LVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWIS 90
L G + L + G+ CL C+ ++ILS ++ +VDPC +FF +AC GWI
Sbjct: 76 LAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIK 135
Query: 91 NNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEK 150
NP+P+ +G + L + +K LLE S + +EA +KA++ Y +CMNE IE+
Sbjct: 136 ANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASV--SEAERKAQVYYRACMNETRIEE 193
Query: 151 ADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSP 210
AKPL+ ++ W + G W++ F TL Y S F +YVS
Sbjct: 194 LRAKPLMELIERLG-GWNIT-------GPWAKDNFQ--DTLQVVTAHYRTSPFFSVYVSA 243
Query: 211 DDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRA-EH 269
D K SN +++++DQ+ L L R+ YL N TE + +MV LLG A
Sbjct: 244 DSKNSNSNVIQVDQSGLGLPSRDYYL-NKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRP 302
Query: 270 DMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIPQFDWLGYIKKVIDTRLYP 328
M+ +L E +A I IP E R E + Y+K+ +EL + P +WL ++ +T YP
Sbjct: 303 QMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL----NTIFYP 358
Query: 329 HLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLE 388
+I+ SE +VV +Y + + ++ + + + NY++W +V L +RFQ +
Sbjct: 359 --VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEK 416
Query: 389 FSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFI 447
F V+ GT T LP+W CV+ E+ L + +G MFV F ED K + E++ ++ AF
Sbjct: 417 FMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFE 476
Query: 448 DMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVL 507
+ L +WMD T++ AKEKA A+ +GYP FIM+ +++ YF N +
Sbjct: 477 ESLSTL-KWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAM 535
Query: 508 QTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPR 567
+ + + LRKA + +W P VNA+YS + N+I FPAG LQ PF+ + P+
Sbjct: 536 RFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSS-PK 594
Query: 568 SLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627
+L++G IGV+VGHE TH FD+ GR+YDK+GNL PWW S E FK +T+CM+ QYSNY
Sbjct: 595 ALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNY-- 652
Query: 628 KKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLS 687
G V G+ TLGENIADNGGL+ A+RAY+ W+ ++ G E LP + TNNQLFFL
Sbjct: 653 SVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWV--KKNGAEHS-LPTLGLTNNQLFFLG 709
Query: 688 YAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCR 747
+A V C+ PE++ E + HSP +FRV G++SN +EF + F CPP S MN C
Sbjct: 710 FAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMN-PPHKCE 768
Query: 748 LW 749
+W
Sbjct: 769 VW 770
>gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens]
Length = 736
Score = 461 bits (1186), Expect = e-129
Identities = 266/756 (35%), Positives = 412/756 (54%), Gaps = 34/756 (4%)
Query: 2 EAETGSSV--ETGKKANRGTRIAL-VVFVGGTLVLGTILF--LVSQGL-LSLQAKQEYCL 55
E GS+V + G + G+R L +V G +L+L +L LV+ G+ CL
Sbjct: 7 ELGAGSNVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCL 66
Query: 56 KPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKL 115
CI A IL ++ V PC++F++F+C GWI NP+P+ + + L L
Sbjct: 67 TEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAIL 126
Query: 116 KELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIG 175
K LLE + + +EA QK + Y SC+ + IE+ A+PL ++ W +
Sbjct: 127 KHLLENT-TFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIG-GWNIT----- 179
Query: 176 PEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDY 235
G W + F ++ L G Y + F +Y+S D K+SN +++++DQ+ L L R+ Y
Sbjct: 180 --GPWDQDNF--MEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYY 235
Query: 236 LDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEA 295
L N T + A +M + +LLG + M+ VL LEI++A I +P + R E
Sbjct: 236 L-NRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEE 294
Query: 296 -MYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRIL 354
+Y+KM+ISEL A+ P DWL ++ ++ ++S SE VVV Y + + ++
Sbjct: 295 KIYHKMSISELQALAPSMDWLEFLSFLLSPL------ELSDSEPVVVYGMDYLQQVSELI 348
Query: 355 GSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTT-TLLPQWDKCVNFIESA 413
+ NYL+W +V +L RRF+ + + GT + +P+W C++ + A
Sbjct: 349 NRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDA 408
Query: 414 LPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVL 473
L + +G +FV F KE+ E ++ +R AF + L + WMD T++ AKEKA A+
Sbjct: 409 LGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALG-QLVWMDEKTRQAAKEKADAIY 467
Query: 474 AKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTN 533
+G+P+FI+ +++ + SE +F N+L + A+ LRK + +W
Sbjct: 468 DMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMT 527
Query: 534 PTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKY 593
P TVNA+Y + N+I FPAG LQ PF+ +P++L++G IGV++GHE TH FD+ GR+Y
Sbjct: 528 PQTVNAYYLPTKNEIVFPAGILQAPFY-ARNHPKALNFGGIGVVMGHELTHAFDDQGREY 586
Query: 594 DKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREA 653
DK GNL PWW ES F+ T CM QY+ Y + G + G++TLGENIADNGGL+ A
Sbjct: 587 DKEGNLRPWWQNESLAAFRNHTACMEEQYNQY--QVNGERLNGRQTLGENIADNGGLKAA 644
Query: 654 FRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPP 713
+ AY+ W+ R+ G EE LP + TN+QLFF+ +A V C+ PE++ E + HSP
Sbjct: 645 YNAYKAWL--RKHG-EEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPA 701
Query: 714 QFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749
+FRV G +SN +F + F CP S MN G C +W
Sbjct: 702 RFRVLGTLSNSRDFLRHFGCPVGSPMNPG-QLCEVW 736
>gi|153945836 endothelin converting enzyme 2 isoform E [Homo
sapiens]
Length = 765
Score = 459 bits (1182), Expect = e-129
Identities = 262/746 (35%), Positives = 407/746 (54%), Gaps = 32/746 (4%)
Query: 10 ETGKKANRGTRIAL-VVFVGGTLVLGTILF--LVSQGL-LSLQAKQEYCLKPECIEAAAA 65
+ G + G+R L +V G +L+L +L LV+ G+ CL CI A
Sbjct: 46 QKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGK 105
Query: 66 ILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISR 125
IL ++ V PC++F++F+C GWI NP+P+ + + L LK LLE + +
Sbjct: 106 ILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENT-TF 164
Query: 126 RRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKF 185
+EA QK + Y SC+ + IE+ A+PL ++ W + G W + F
Sbjct: 165 NSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIG-GWNIT-------GPWDQDNF 216
Query: 186 SLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSY 245
++ L G Y + F +Y+S D K+SN +++++DQ+ L L R+ YL N T +
Sbjct: 217 --MEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYL-NRTANEKV 273
Query: 246 RDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEA-MYNKMNISE 304
A +M + +LLG + M+ VL LEI++A I +P + R E +Y+KM+ISE
Sbjct: 274 LTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISE 333
Query: 305 LSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIAN 364
L A+ P DWL ++ ++ ++S SE VVV Y + + ++ + N
Sbjct: 334 LQALAPSMDWLEFLSFLLSPL------ELSDSEPVVVYGMDYLQQVSELINRTEPSILNN 387
Query: 365 YLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFV 423
YL+W +V +L RRF+ + + GT + +P+W C++ + AL + +G +FV
Sbjct: 388 YLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFV 447
Query: 424 DVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIM 483
F KE+ E ++ +R AF + L + WMD T++ AKEKA A+ +G+P+FI+
Sbjct: 448 KATFDRQSKEIAEGMISEIRTAFEEALG-QLVWMDEKTRQAAKEKADAIYDMIGFPDFIL 506
Query: 484 NDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSA 543
+++ + SE +F N+L + A+ LRK + +W P TVNA+Y
Sbjct: 507 EPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLP 566
Query: 544 STNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWW 603
+ N+I FPAG LQ PF+ +P++L++G IGV++GHE TH FD+ GR+YDK GNL PWW
Sbjct: 567 TKNEIVFPAGILQAPFY-ARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWW 625
Query: 604 STESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWIND 663
ES F+ T CM QY+ Y + G + G++TLGENIADNGGL+ A+ AY+ W+
Sbjct: 626 QNESLAAFRNHTACMEEQYNQY--QVNGERLNGRQTLGENIADNGGLKAAYNAYKAWL-- 681
Query: 664 RRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISN 723
R+ G EE LP + TN+QLFF+ +A V C+ PE++ E + HSP +FRV G +SN
Sbjct: 682 RKHG-EEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSN 740
Query: 724 FEEFQKAFNCPPNSTMNRGMDSCRLW 749
+F + F CP S MN G C +W
Sbjct: 741 SRDFLRHFGCPVGSPMNPG-QLCEVW 765
>gi|153945771 endothelin converting enzyme 2 isoform D [Homo
sapiens]
Length = 811
Score = 459 bits (1182), Expect = e-129
Identities = 262/746 (35%), Positives = 407/746 (54%), Gaps = 32/746 (4%)
Query: 10 ETGKKANRGTRIAL-VVFVGGTLVLGTILF--LVSQGL-LSLQAKQEYCLKPECIEAAAA 65
+ G + G+R L +V G +L+L +L LV+ G+ CL CI A
Sbjct: 92 QKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGK 151
Query: 66 ILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISR 125
IL ++ V PC++F++F+C GWI NP+P+ + + L LK LLE + +
Sbjct: 152 ILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENT-TF 210
Query: 126 RRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKF 185
+EA QK + Y SC+ + IE+ A+PL ++ W + G W + F
Sbjct: 211 NSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIG-GWNIT-------GPWDQDNF 262
Query: 186 SLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSY 245
++ L G Y + F +Y+S D K+SN +++++DQ+ L L R+ YL N T +
Sbjct: 263 --MEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYL-NRTANEKV 319
Query: 246 RDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEA-MYNKMNISE 304
A +M + +LLG + M+ VL LEI++A I +P + R E +Y+KM+ISE
Sbjct: 320 LTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISE 379
Query: 305 LSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIAN 364
L A+ P DWL ++ ++ ++S SE VVV Y + + ++ + N
Sbjct: 380 LQALAPSMDWLEFLSFLLSPL------ELSDSEPVVVYGMDYLQQVSELINRTEPSILNN 433
Query: 365 YLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFV 423
YL+W +V +L RRF+ + + GT + +P+W C++ + AL + +G +FV
Sbjct: 434 YLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFV 493
Query: 424 DVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIM 483
F KE+ E ++ +R AF + L + WMD T++ AKEKA A+ +G+P+FI+
Sbjct: 494 KATFDRQSKEIAEGMISEIRTAFEEALG-QLVWMDEKTRQAAKEKADAIYDMIGFPDFIL 552
Query: 484 NDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSA 543
+++ + SE +F N+L + A+ LRK + +W P TVNA+Y
Sbjct: 553 EPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLP 612
Query: 544 STNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWW 603
+ N+I FPAG LQ PF+ +P++L++G IGV++GHE TH FD+ GR+YDK GNL PWW
Sbjct: 613 TKNEIVFPAGILQAPFY-ARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWW 671
Query: 604 STESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWIND 663
ES F+ T CM QY+ Y + G + G++TLGENIADNGGL+ A+ AY+ W+
Sbjct: 672 QNESLAAFRNHTACMEEQYNQY--QVNGERLNGRQTLGENIADNGGLKAAYNAYKAWL-- 727
Query: 664 RRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISN 723
R+ G EE LP + TN+QLFF+ +A V C+ PE++ E + HSP +FRV G +SN
Sbjct: 728 RKHG-EEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSN 786
Query: 724 FEEFQKAFNCPPNSTMNRGMDSCRLW 749
+F + F CP S MN G C +W
Sbjct: 787 SRDFLRHFGCPVGSPMNPG-QLCEVW 811
>gi|153945761 endothelin converting enzyme 2 isoform A [Homo
sapiens]
Length = 883
Score = 459 bits (1182), Expect = e-129
Identities = 262/746 (35%), Positives = 407/746 (54%), Gaps = 32/746 (4%)
Query: 10 ETGKKANRGTRIAL-VVFVGGTLVLGTILF--LVSQGL-LSLQAKQEYCLKPECIEAAAA 65
+ G + G+R L +V G +L+L +L LV+ G+ CL CI A
Sbjct: 164 QKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGK 223
Query: 66 ILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISR 125
IL ++ V PC++F++F+C GWI NP+P+ + + L LK LLE + +
Sbjct: 224 ILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENT-TF 282
Query: 126 RRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKF 185
+EA QK + Y SC+ + IE+ A+PL ++ W + G W + F
Sbjct: 283 NSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIG-GWNIT-------GPWDQDNF 334
Query: 186 SLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSY 245
++ L G Y + F +Y+S D K+SN +++++DQ+ L L R+ YL N T +
Sbjct: 335 --MEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYL-NRTANEKV 391
Query: 246 RDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEA-MYNKMNISE 304
A +M + +LLG + M+ VL LEI++A I +P + R E +Y+KM+ISE
Sbjct: 392 LTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISE 451
Query: 305 LSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIAN 364
L A+ P DWL ++ ++ ++S SE VVV Y + + ++ + N
Sbjct: 452 LQALAPSMDWLEFLSFLLSPL------ELSDSEPVVVYGMDYLQQVSELINRTEPSILNN 505
Query: 365 YLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFV 423
YL+W +V +L RRF+ + + GT + +P+W C++ + AL + +G +FV
Sbjct: 506 YLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFV 565
Query: 424 DVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIM 483
F KE+ E ++ +R AF + L + WMD T++ AKEKA A+ +G+P+FI+
Sbjct: 566 KATFDRQSKEIAEGMISEIRTAFEEALG-QLVWMDEKTRQAAKEKADAIYDMIGFPDFIL 624
Query: 484 NDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSA 543
+++ + SE +F N+L + A+ LRK + +W P TVNA+Y
Sbjct: 625 EPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLP 684
Query: 544 STNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWW 603
+ N+I FPAG LQ PF+ +P++L++G IGV++GHE TH FD+ GR+YDK GNL PWW
Sbjct: 685 TKNEIVFPAGILQAPFY-ARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWW 743
Query: 604 STESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWIND 663
ES F+ T CM QY+ Y + G + G++TLGENIADNGGL+ A+ AY+ W+
Sbjct: 744 QNESLAAFRNHTACMEEQYNQY--QVNGERLNGRQTLGENIADNGGLKAAYNAYKAWL-- 799
Query: 664 RRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISN 723
R+ G EE LP + TN+QLFF+ +A V C+ PE++ E + HSP +FRV G +SN
Sbjct: 800 RKHG-EEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSN 858
Query: 724 FEEFQKAFNCPPNSTMNRGMDSCRLW 749
+F + F CP S MN G C +W
Sbjct: 859 SRDFLRHFGCPVGSPMNPG-QLCEVW 883
>gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens]
Length = 775
Score = 374 bits (959), Expect = e-103
Identities = 231/733 (31%), Positives = 390/733 (53%), Gaps = 29/733 (3%)
Query: 23 LVVFVGGTLVLGTILFLVSQGLLSLQ--AKQEYCLKPECIEAAAAILS-KVNLSVDPCDN 79
LV G +L +L L G ++ A E C + + AA L+ ++ S+DPC +
Sbjct: 66 LVFAAGLCAILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLAANLDASIDPCQD 125
Query: 80 FFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILY 139
F+ FAC GW+ + IP+D +YG + + +L+ LL + A +K + +
Sbjct: 126 FYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARP-GGGPGGAAQRKVRAFF 184
Query: 140 SSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYS 199
SC++ + IE+ +P+L ++ W + + P GV + ++ L + L +G YS
Sbjct: 185 RSCLDMREIERLGPRPMLEVIEDCG-GWDLGGAEERP-GVAA--RWDLNRLLYKAQGVYS 240
Query: 200 NSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVL 259
+ L VS DD+ S+ +++++DQ L+L R YL +++ A FM L
Sbjct: 241 AAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSL 300
Query: 260 LGANSSRAEHDMKSVLRLEIKIAEIMIPHEN---RTSEAMYNKMNISELSAMIPQFDWLG 316
LGA++ E + +L++E ++A I + + R +MYNK+ + +L + P W
Sbjct: 301 LGADA--VEQKAQEILQVEQQLANITVSEHDDLRRDVSSMYNKVTLGQLQKITPHLRWKW 358
Query: 317 YIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIP 376
+ ++ +D S E VV+ Y + + +++ S + + NYLVWR+V
Sbjct: 359 LLDQIFQ-------EDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVVVVLSE 411
Query: 377 NLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMME 436
+LS F+ E ++ ++G+ C+ +G +FV +F K ++
Sbjct: 412 HLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQ 471
Query: 437 ELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIK 496
+LVE +++ LE E +WMDA T+ A+ K + ++ VGYP+F++ V+++ + +
Sbjct: 472 QLVEDIKYILGQRLE-ELDWMDAETRAAARAKLQYMMVMVGYPDFLLKPDAVDKEYE-FE 529
Query: 497 FSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQ 556
E YF N+L + ++ Q +R+ V K+ W P +NA+Y + NQ+ FPAG LQ
Sbjct: 530 VHEKTYFKNILNSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQMVFPAGILQ 589
Query: 557 KPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTK 616
P + ++P+SL+YG IG I+GHE THG+D+ G +YD++GNL WW+ S +F K +
Sbjct: 590 -PTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAE 648
Query: 617 CMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGI 676
C++ Y N+ V GK TLGENIAD GGL+ A+ AY+KW+ R G E P LP +
Sbjct: 649 CIVRLYDNF--TVYNQRVNGKHTLGENIADMGGLKLAYHAYQKWV--REHGPEHP-LPRL 703
Query: 677 TFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPN 736
+T++QLFF+++A C R ++ QV H+P +RV G++S FEEF +AF+CP +
Sbjct: 704 KYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKD 763
Query: 737 STMNRGMDSCRLW 749
S MN C +W
Sbjct: 764 SPMNPA-HKCSVW 775
>gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens]
Length = 732
Score = 209 bits (531), Expect = 1e-53
Identities = 175/706 (24%), Positives = 313/706 (44%), Gaps = 60/706 (8%)
Query: 54 CLKPECIEAAAAILSKVNLSVDPCDNFFRFACD-GWISNNPIPEDMPSYGVYPWLRHNVD 112
C C++ L+ N SV PC +FF FAC +NN E L
Sbjct: 77 CETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQE----------LATKNK 126
Query: 113 LKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLES 172
+L+ +LE S + +KA Y+SCM+ AIE A PL ++ W +
Sbjct: 127 NRLRRILEVQNSWHPGSGE-EKAFQFYNSCMDTLAIEAAGTGPLRQVIEELG-GWRI--- 181
Query: 173 NIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVR 232
G W+ F+ +TL QY + F R Y+ P + + ++++DQ + ++
Sbjct: 182 ----SGKWTSLNFN--RTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLK 235
Query: 233 EDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRT 292
+D + A+ +R+ L ++ LLG + S+ + + + ++ + + P E R
Sbjct: 236 QDQ-EQKIYAQIFREYL-TYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRR 293
Query: 293 SEA-MYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLF 351
++ ++ + I +L M P DWL ++ +SPS+++VV +Y K++
Sbjct: 294 AQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPM------SLSPSQSLVVHDVEYLKNMS 347
Query: 352 RILGS---ERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTT-----LLPQW 403
+++ +++ + ++++ +V + P L +FQ + S+ ++ T P+W
Sbjct: 348 QLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRW 407
Query: 404 DKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKR 463
KCV + + +FV F + +L +R A I L + WM+ T+
Sbjct: 408 MKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRL-RNLPWMNEETQN 466
Query: 464 KAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRK 523
A++K + ++G E+ + ++ I+ + + +VL + L +
Sbjct: 467 MAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSS-FLQSVLSCVRSLRARIVQSFLQ 525
Query: 524 AVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFT 583
P+ W +P VNA+YS S + + FPAG LQ PFF YPR++++GA G I+ HE
Sbjct: 526 PHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFF-HPGYPRAVNFGAAGSIMAHELL 584
Query: 584 HGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGEN 643
H F L P + ++ + ++ + + + T EN
Sbjct: 585 HIFYQ---------LLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLEN 635
Query: 644 IADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAARE 703
AD GGL A +AY K + R G E +LP + + Q+FF SYA V C P+ + +
Sbjct: 636 AADVGGLAIALQAYSKRLL-RHHG--ETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHD 692
Query: 704 QVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749
HSPP RV+G +S+ F + F C + +N C+LW
Sbjct: 693 -----THSPPHLRVHGPLSSTPAFARYFRCARGALLNPS-SRCQLW 732
>gi|223671856 coiled-coil domain containing 85C [Homo sapiens]
Length = 419
Score = 32.0 bits (71), Expect = 2.2
Identities = 14/50 (28%), Positives = 24/50 (48%)
Query: 598 NLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADN 647
NLD EE EK K ++ + N W+K G K ++ ++++ N
Sbjct: 364 NLDRQLQDSCEEDLSEKEKAIVREMCNVVWRKLGDAASSKPSIRQHLSGN 413
>gi|212549782 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 31.6 bits (70), Expect = 2.8
Identities = 30/117 (25%), Positives = 52/117 (44%), Gaps = 16/117 (13%)
Query: 340 VVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRI--------PNLSRRFQYRWLEFSR 391
++ VP +++ +L RK NY+ ++ +S I LS + L +
Sbjct: 1028 IIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHK 1087
Query: 392 VIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFID 448
+ + TTL Q + C + IES L V VD F++ +M ++L W F+D
Sbjct: 1088 ISKSVTTL--QKNLC-DIIESKLKQVKKNGIVDRLFEQQLPDMKKKL-----WKFVD 1136
>gi|6912288 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 31.6 bits (70), Expect = 2.8
Identities = 30/117 (25%), Positives = 52/117 (44%), Gaps = 16/117 (13%)
Query: 340 VVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRI--------PNLSRRFQYRWLEFSR 391
++ VP +++ +L RK NY+ ++ +S I LS + L +
Sbjct: 1028 IIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHK 1087
Query: 392 VIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFID 448
+ + TTL Q + C + IES L V VD F++ +M ++L W F+D
Sbjct: 1088 ISKSVTTL--QKNLC-DIIESKLKQVKKNGIVDRLFEQQLPDMKKKL-----WKFVD 1136
>gi|212549532 caspase 8 associated protein 2 [Homo sapiens]
Length = 1982
Score = 31.6 bits (70), Expect = 2.8
Identities = 30/117 (25%), Positives = 52/117 (44%), Gaps = 16/117 (13%)
Query: 340 VVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRI--------PNLSRRFQYRWLEFSR 391
++ VP +++ +L RK NY+ ++ +S I LS + L +
Sbjct: 1028 IIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHK 1087
Query: 392 VIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFID 448
+ + TTL Q + C + IES L V VD F++ +M ++L W F+D
Sbjct: 1088 ISKSVTTL--QKNLC-DIIESKLKQVKKNGIVDRLFEQQLPDMKKKL-----WKFVD 1136
>gi|221136806 zinc finger, CCHC domain containing 18 [Homo sapiens]
Length = 403
Score = 30.8 bits (68), Expect = 4.8
Identities = 22/88 (25%), Positives = 39/88 (44%), Gaps = 12/88 (13%)
Query: 430 DKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVN 489
+K+E + +E I M+ +E +W DA KRK +++ ++ + P
Sbjct: 201 NKQERLPNFLE-----LIKMIREEEDWDDAFIKRKRPKRSEPIMERAASPVAF------- 248
Query: 490 EDLKAIKFSEADYFGNVLQTRKYLAQSD 517
+ + I S AD NV++ L SD
Sbjct: 249 QGAQPIAISSADCNCNVIEIDDTLDDSD 276
>gi|115495445 ankyrin repeat domain 30A [Homo sapiens]
Length = 1341
Score = 30.4 bits (67), Expect = 6.3
Identities = 35/139 (25%), Positives = 63/139 (45%), Gaps = 14/139 (10%)
Query: 114 KLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESN 173
K K+ E S E + + + ++K I+K + K L SP + +L++N
Sbjct: 620 KQKDYEENSWDTESLCETVSQKDVCLPKAAHQKEIDKINGK-----LEGSPVKDGLLKAN 674
Query: 174 IGPEGVWSERKFSLLQTLATFRGQYSN--SVF---IRLYVSPDDKA---SNEHILKLDQA 225
G + V K L + TF+ + S F I + S +KA NE L+ D+
Sbjct: 675 CGMK-VSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADEI 733
Query: 226 TLSLAVREDYLDNSTEAKS 244
S + ++DY ++S +++S
Sbjct: 734 LPSESKQKDYEESSWDSES 752
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,057,281
Number of Sequences: 37866
Number of extensions: 1175359
Number of successful extensions: 2777
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2610
Number of HSP's gapped (non-prelim): 32
length of query: 749
length of database: 18,247,518
effective HSP length: 110
effective length of query: 639
effective length of database: 14,082,258
effective search space: 8998562862
effective search space used: 8998562862
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.