Guide to the Human Genome
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Search of human proteins with 8923819

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8923819 Impact homolog [Homo sapiens]
         (320 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8923819 Impact homolog [Homo sapiens]                              657   0.0  
gi|34577102 ring finger protein 14 isoform 1 [Homo sapiens]            46   5e-05
gi|34577100 ring finger protein 14 isoform 1 [Homo sapiens]            46   5e-05
gi|34577098 ring finger protein 14 isoform 1 [Homo sapiens]            46   5e-05
gi|4757762 ring finger protein 14 isoform 1 [Homo sapiens]             46   5e-05
gi|55953123 RWD domain containing 1 isoform a [Homo sapiens]           40   0.004
gi|65287717 eukaryotic translation initiation factor 2 alpha kin...    36   0.052
gi|38201677 teashirt family zinc finger 1 [Homo sapiens]               32   0.75 
gi|34878787 ring finger protein 25 [Homo sapiens]                      32   0.75 
gi|206597549 coiled-coil domain containing 36 [Homo sapiens]           31   1.3  
gi|206597547 coiled-coil domain containing 36 [Homo sapiens]           31   1.3  
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    30   3.7  
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    30   3.7  
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    30   3.7  
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       29   6.4  
gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo...    29   6.4  
gi|38569484 kinesin family member 21A [Homo sapiens]                   28   8.3  

>gi|8923819 Impact homolog [Homo sapiens]
          Length = 320

 Score =  657 bits (1694), Expect = 0.0
 Identities = 320/320 (100%), Positives = 320/320 (100%)

Query: 1   MAEGDAGSDQRQNEEIEAMAAIYGEEWCVIDDCAKIFCIRISDDIDDPKWTLCLQVMLPN 60
           MAEGDAGSDQRQNEEIEAMAAIYGEEWCVIDDCAKIFCIRISDDIDDPKWTLCLQVMLPN
Sbjct: 1   MAEGDAGSDQRQNEEIEAMAAIYGEEWCVIDDCAKIFCIRISDDIDDPKWTLCLQVMLPN 60

Query: 61  EYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVLIQKSQMT 120
           EYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVLIQKSQMT
Sbjct: 61  EYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVLIQKSQMT 120

Query: 121 EPGPDVKKKTEEEDVECEDDLILACQPESSVKALDFDISETRTEVEVEELPPIDHGIPIT 180
           EPGPDVKKKTEEEDVECEDDLILACQPESSVKALDFDISETRTEVEVEELPPIDHGIPIT
Sbjct: 121 EPGPDVKKKTEEEDVECEDDLILACQPESSVKALDFDISETRTEVEVEELPPIDHGIPIT 180

Query: 181 DRRSTFQAHLAPVVCPKQVKMVLSKLYENKKIASATHNIYAYRIYCEDKQTFLQDCEDDG 240
           DRRSTFQAHLAPVVCPKQVKMVLSKLYENKKIASATHNIYAYRIYCEDKQTFLQDCEDDG
Sbjct: 181 DRRSTFQAHLAPVVCPKQVKMVLSKLYENKKIASATHNIYAYRIYCEDKQTFLQDCEDDG 240

Query: 241 ETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKHINNCARNILVEKNYTNSPEE 300
           ETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKHINNCARNILVEKNYTNSPEE
Sbjct: 241 ETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKHINNCARNILVEKNYTNSPEE 300

Query: 301 SSKALGKNKKVRKDKKRNEH 320
           SSKALGKNKKVRKDKKRNEH
Sbjct: 301 SSKALGKNKKVRKDKKRNEH 320


>gi|34577102 ring finger protein 14 isoform 1 [Homo sapiens]
          Length = 474

 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 30/137 (21%), Positives = 65/137 (47%), Gaps = 24/137 (17%)

Query: 10  QRQNEEIEAMAAIY------------GEEWCVIDDCAKIFCIRISDDIDDP------KWT 51
           + Q +E+ A+A+IY            G E  +  D  + F I +S + ++       ++T
Sbjct: 7   EAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQNSGFEYT 66

Query: 52  LC------LQVMLPNEYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLW 105
           +C      L   LP +YP ++PP + L+  WL   + + L   L+ ++ ++ G  +L+ W
Sbjct: 67  ICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAW 126

Query: 106 VEKIRDVLIQKSQMTEP 122
           ++ +++  +    +  P
Sbjct: 127 MQFLKEETLAYLNIVSP 143


>gi|34577100 ring finger protein 14 isoform 1 [Homo sapiens]
          Length = 474

 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 30/137 (21%), Positives = 65/137 (47%), Gaps = 24/137 (17%)

Query: 10  QRQNEEIEAMAAIY------------GEEWCVIDDCAKIFCIRISDDIDDP------KWT 51
           + Q +E+ A+A+IY            G E  +  D  + F I +S + ++       ++T
Sbjct: 7   EAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQNSGFEYT 66

Query: 52  LC------LQVMLPNEYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLW 105
           +C      L   LP +YP ++PP + L+  WL   + + L   L+ ++ ++ G  +L+ W
Sbjct: 67  ICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAW 126

Query: 106 VEKIRDVLIQKSQMTEP 122
           ++ +++  +    +  P
Sbjct: 127 MQFLKEETLAYLNIVSP 143


>gi|34577098 ring finger protein 14 isoform 1 [Homo sapiens]
          Length = 474

 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 30/137 (21%), Positives = 65/137 (47%), Gaps = 24/137 (17%)

Query: 10  QRQNEEIEAMAAIY------------GEEWCVIDDCAKIFCIRISDDIDDP------KWT 51
           + Q +E+ A+A+IY            G E  +  D  + F I +S + ++       ++T
Sbjct: 7   EAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQNSGFEYT 66

Query: 52  LC------LQVMLPNEYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLW 105
           +C      L   LP +YP ++PP + L+  WL   + + L   L+ ++ ++ G  +L+ W
Sbjct: 67  ICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAW 126

Query: 106 VEKIRDVLIQKSQMTEP 122
           ++ +++  +    +  P
Sbjct: 127 MQFLKEETLAYLNIVSP 143


>gi|4757762 ring finger protein 14 isoform 1 [Homo sapiens]
          Length = 474

 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 30/137 (21%), Positives = 65/137 (47%), Gaps = 24/137 (17%)

Query: 10  QRQNEEIEAMAAIY------------GEEWCVIDDCAKIFCIRISDDIDDP------KWT 51
           + Q +E+ A+A+IY            G E  +  D  + F I +S + ++       ++T
Sbjct: 7   EAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQNSGFEYT 66

Query: 52  LC------LQVMLPNEYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLW 105
           +C      L   LP +YP ++PP + L+  WL   + + L   L+ ++ ++ G  +L+ W
Sbjct: 67  ICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAW 126

Query: 106 VEKIRDVLIQKSQMTEP 122
           ++ +++  +    +  P
Sbjct: 127 MQFLKEETLAYLNIVSP 143


>gi|55953123 RWD domain containing 1 isoform a [Homo sapiens]
          Length = 243

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 36/143 (25%), Positives = 73/143 (51%), Gaps = 11/143 (7%)

Query: 5   DAGSDQRQNEEIEAMAAIYGEEWCVIDDCAKIFCIRISDDIDDPKWTL--CLQVMLPNEY 62
           D G +QR   E+EA+ +IY + + V+ +    F I ++ +  +   T+   L+     +Y
Sbjct: 3   DYGEEQRN--ELEALESIYPDSFTVLSENPPSFTITVTSEAGENDETVQTTLKFTYSEKY 60

Query: 63  PGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQ---NIGESILYLWVEKIRDVLIQ-KSQ 118
           P  A P+Y++ +   +  E  D+S+ L+ + +Q   N+G  +++  V  +++ L +   Q
Sbjct: 61  PDEA-PLYEIFSQ--ENLEDNDVSDILKLLALQAEENLGMVMIFTLVTAVQEKLNEIVDQ 117

Query: 119 MTEPGPDVKKKTEEEDVECEDDL 141
           +     + KK+ E+E  E E  L
Sbjct: 118 IKTRREEEKKQKEKEAEEAEKQL 140


>gi|65287717 eukaryotic translation initiation factor 2 alpha kinase
           4 [Homo sapiens]
          Length = 1649

 Score = 35.8 bits (81), Expect = 0.052
 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 16/137 (11%)

Query: 10  QRQNEEIEAMAAIYGEEWCVI--DDCA------KIFCIRISDDI--DDPKWTLCLQVMLP 59
           QRQ+ E++A+ AIYG ++  +  D C       +I  +     +  ++    + L+V  P
Sbjct: 21  QRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLYPQGLTGEEVYVKVDLRVKCP 80

Query: 60  NEYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVLIQKSQM 119
             YP   P I   NA  L  +    L + LEE+  ++ GE +++     ++  L   S+ 
Sbjct: 81  PTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGEVMIFELAYHVQSFL---SEH 137

Query: 120 TEPGPDVKKKTEEEDVE 136
            +P P   K   EE +E
Sbjct: 138 NKPPP---KSFHEEMLE 151


>gi|38201677 teashirt family zinc finger 1 [Homo sapiens]
          Length = 1032

 Score = 32.0 bits (71), Expect = 0.75
 Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 2/85 (2%)

Query: 77  LKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVLIQKSQMTEPGPDVKKKTEEEDVE 136
           ++G+E  D    L+ +Y  +  ES+  L V  I+    QK  + EP P + K        
Sbjct: 252 MEGKE--DAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVPAITKLVPSTKKR 309

Query: 137 CEDDLILACQPESSVKALDFDISET 161
              DL   C PE +  A +  +SE+
Sbjct: 310 ALQDLAPPCSPEPAGMAAEVALSES 334


>gi|34878787 ring finger protein 25 [Homo sapiens]
          Length = 459

 Score = 32.0 bits (71), Expect = 0.75
 Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 8/107 (7%)

Query: 15  EIEAMAAIYGEEWCVIDDCAKIFCIRI--------SDDIDDPKWTLCLQVMLPNEYPGTA 66
           E+E + +IY +E  VI    +     I        ++D D       L + +P EYP   
Sbjct: 19  EVEVLESIYLDELQVIKGNGRTSPWEIYITLHPATAEDQDSQYVCFTLVLQVPAEYPHEV 78

Query: 67  PPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVL 113
           P I   N   L  ++   +   L  +    +G ++LY  +EK +++L
Sbjct: 79  PQISIRNPRGLSDEQIHTILQVLGHVAKAGLGTAMLYELIEKGKEIL 125


>gi|206597549 coiled-coil domain containing 36 [Homo sapiens]
          Length = 594

 Score = 31.2 bits (69), Expect = 1.3
 Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 2/52 (3%)

Query: 93  YIQNIGESILYLW--VEKIRDVLIQKSQMTEPGPDVKKKTEEEDVECEDDLI 142
           ++ N+ ESIL L   VEK  D L  +SQ      +   KT +E ++ ++DL+
Sbjct: 138 FVSNVRESILRLQTSVEKSEDHLSSRSQSILDSLETVAKTLQETIQAQNDLV 189


>gi|206597547 coiled-coil domain containing 36 [Homo sapiens]
          Length = 594

 Score = 31.2 bits (69), Expect = 1.3
 Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 2/52 (3%)

Query: 93  YIQNIGESILYLW--VEKIRDVLIQKSQMTEPGPDVKKKTEEEDVECEDDLI 142
           ++ N+ ESIL L   VEK  D L  +SQ      +   KT +E ++ ++DL+
Sbjct: 138 FVSNVRESILRLQTSVEKSEDHLSSRSQSILDSLETVAKTLQETIQAQNDLV 189


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 29.6 bits (65), Expect = 3.7
 Identities = 20/70 (28%), Positives = 30/70 (42%)

Query: 99   ESILYLWVEKIRDVLIQKSQMTEPGPDVKKKTEEEDVECEDDLILACQPESSVKALDFDI 158
            E  L L  E I D+  +K Q+ E     + +      + ED+  L  Q +  +K L   I
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121

Query: 159  SETRTEVEVE 168
             E   E+E E
Sbjct: 1122 EELEEEIEAE 1131


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 29.6 bits (65), Expect = 3.7
 Identities = 20/70 (28%), Positives = 30/70 (42%)

Query: 99   ESILYLWVEKIRDVLIQKSQMTEPGPDVKKKTEEEDVECEDDLILACQPESSVKALDFDI 158
            E  L L  E I D+  +K Q+ E     + +      + ED+  L  Q +  +K L   I
Sbjct: 1062 EGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI 1121

Query: 159  SETRTEVEVE 168
             E   E+E E
Sbjct: 1122 EELEEEIEAE 1131


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 29.6 bits (65), Expect = 3.7
 Identities = 18/70 (25%), Positives = 28/70 (40%)

Query: 99   ESILYLWVEKIRDVLIQKSQMTEPGPDVKKKTEEEDVECEDDLILACQPESSVKALDFDI 158
            E  L L  E + D    K Q+ E       +  +  +  ED+ +L  Q +  +K L    
Sbjct: 1105 EGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARA 1164

Query: 159  SETRTEVEVE 168
             E   E+E E
Sbjct: 1165 EELEEELEAE 1174


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 28.9 bits (63), Expect = 6.4
 Identities = 20/70 (28%), Positives = 32/70 (45%)

Query: 99   ESILYLWVEKIRDVLIQKSQMTEPGPDVKKKTEEEDVECEDDLILACQPESSVKALDFDI 158
            E  L L  E I D+   K Q+ E     +    +++ + ED+ +LA Q +  +K     I
Sbjct: 1058 EGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARI 1117

Query: 159  SETRTEVEVE 168
             E   E+E E
Sbjct: 1118 EELEEELEAE 1127


>gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo
            sapiens]
          Length = 2168

 Score = 28.9 bits (63), Expect = 6.4
 Identities = 20/113 (17%), Positives = 49/113 (43%), Gaps = 1/113 (0%)

Query: 54   LQVMLPNEYPGTAPPIYQLNAPWLKGQERADLSNSLEEIYIQNIGESILYLWVEKIRDVL 113
            ++V  P ++P   P   ++   W +  +  DL   L+ ++++ I E  L   ++K  D +
Sbjct: 1696 VEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYI 1755

Query: 114  IQKSQMTEPGPDVKKKTEEEDVECEDDLILACQPESSVKALDFDISETRTEVE 166
             Q + +      + +  E E+ +   D++     E     +D  + +   ++E
Sbjct: 1756 TQ-ACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLE 1807


>gi|38569484 kinesin family member 21A [Homo sapiens]
          Length = 1661

 Score = 28.5 bits (62), Expect = 8.3
 Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 6/90 (6%)

Query: 125 DVKKKTEEEDVECEDDLILACQPESSVKALDFDISETRTEVEVEELP---PIDHGIPITD 181
           D +KK E+   E E++ +   + E S +  D +  E   E E +++      D     +D
Sbjct: 569 DQEKKEEKGVSERENNEL---EVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESD 625

Query: 182 RRSTFQAHLAPVVCPKQVKMVLSKLYENKK 211
            ++ +QA LA + C   +K  L    EN +
Sbjct: 626 EKANYQADLANITCEIAIKQKLIDELENSQ 655


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,902,958
Number of Sequences: 37866
Number of extensions: 574071
Number of successful extensions: 1644
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1627
Number of HSP's gapped (non-prelim): 23
length of query: 320
length of database: 18,247,518
effective HSP length: 102
effective length of query: 218
effective length of database: 14,385,186
effective search space: 3135970548
effective search space used: 3135970548
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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