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Search of human proteins with 89031073
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|89031073 PREDICTED: N-acylsphingosine amidohydrolase
(non-lysosomal ceramidase) 2C [Homo sapiens]
(622 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|89031073 PREDICTED: N-acylsphingosine amidohydrolase (non-lys... 1274 0.0
gi|221218981 N-acylsphingosine amidohydrolase 2 isoform a [Homo ... 1248 0.0
gi|221307475 N-acylsphingosine amidohydrolase 2 isoform b [Homo ... 1159 0.0
gi|118442845 N-acylsphingosine amidohydrolase (non-lysosomal cer... 284 2e-76
gi|156766054 PNMA-like 1 isoform b [Homo sapiens] 32 1.7
gi|39780597 PNMA-like 1 isoform a [Homo sapiens] 32 1.7
gi|4505245 mannose receptor C type 1 precursor [Homo sapiens] 32 2.3
gi|57546917 mannose receptor, C type 1-like 1 [Homo sapiens] 32 2.3
>gi|89031073 PREDICTED: N-acylsphingosine amidohydrolase
(non-lysosomal ceramidase) 2C [Homo sapiens]
Length = 622
Score = 1274 bits (3296), Expect = 0.0
Identities = 622/622 (100%), Positives = 622/622 (100%)
Query: 1 MDSEKSSEWRSDVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQ 60
MDSEKSSEWRSDVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQ
Sbjct: 1 MDSEKSSEWRSDVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQ 60
Query: 61 TFQHMVTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTD 120
TFQHMVTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTD
Sbjct: 61 TFQHMVTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTD 120
Query: 121 KEMIVLKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQ 180
KEMIVLKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQ
Sbjct: 121 KEMIVLKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQ 180
Query: 181 GPFVAAFSSSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQ 240
GPFVAAFSSSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQ
Sbjct: 181 GPFVAAFSSSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQ 240
Query: 241 IIGRAMYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAA 300
IIGRAMYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAA
Sbjct: 241 IIGRAMYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAA 300
Query: 301 GTIDGVGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWH 360
GTIDGVGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWH
Sbjct: 301 GTIDGVGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWH 360
Query: 361 PDIVDVQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTH 420
PDIVDVQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTH
Sbjct: 361 PDIVDVQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTH 420
Query: 421 YITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLI 480
YITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLI
Sbjct: 421 YITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLI 480
Query: 481 VPLIPSIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQNHQTFLTVEK 540
VPLIPSIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQNHQTFLTVEK
Sbjct: 481 VPLIPSIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQNHQTFLTVEK 540
Query: 541 YEATSTSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQD 600
YEATSTSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQD
Sbjct: 541 YEATSTSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQD 600
Query: 601 ILKPAVILSFEGTSPAFEVVTI 622
ILKPAVILSFEGTSPAFEVVTI
Sbjct: 601 ILKPAVILSFEGTSPAFEVVTI 622
>gi|221218981 N-acylsphingosine amidohydrolase 2 isoform a [Homo
sapiens]
Length = 780
Score = 1248 bits (3230), Expect = 0.0
Identities = 610/617 (98%), Positives = 612/617 (99%)
Query: 6 SSEWRSDVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHM 65
S R +VLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHM
Sbjct: 164 SQRLRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHM 223
Query: 66 VTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIV 125
VTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIV
Sbjct: 224 VTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIV 283
Query: 126 LKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVA 185
LKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVA
Sbjct: 284 LKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVA 343
Query: 186 AFSSSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRA 245
AF+SSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRA
Sbjct: 344 AFASSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRA 403
Query: 246 MYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDG 305
MYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDG
Sbjct: 404 MYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDG 463
Query: 306 VGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVD 365
VGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVD
Sbjct: 464 VGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVD 523
Query: 366 VQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTY 425
VQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTY
Sbjct: 524 VQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTY 583
Query: 426 EEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIP 485
EEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIP
Sbjct: 584 EEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIP 643
Query: 486 SIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQNHQTFLTVEKYEATS 545
SIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQ HQTFLTVEKYEATS
Sbjct: 644 SIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLTVEKYEATS 703
Query: 546 TSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPA 605
TSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPA
Sbjct: 704 TSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPA 763
Query: 606 VILSFEGTSPAFEVVTI 622
VILSFEGTSPAFEVVTI
Sbjct: 764 VILSFEGTSPAFEVVTI 780
>gi|221307475 N-acylsphingosine amidohydrolase 2 isoform b [Homo
sapiens]
Length = 745
Score = 1159 bits (2999), Expect = 0.0
Identities = 575/617 (93%), Positives = 577/617 (93%), Gaps = 35/617 (5%)
Query: 6 SSEWRSDVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHM 65
S R +VLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHM
Sbjct: 164 SQRLRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHM 223
Query: 66 VTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIV 125
VTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIV
Sbjct: 224 VTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIV 283
Query: 126 LKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVA 185
LKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVA
Sbjct: 284 LKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLEQEKNKGYLPGQGPFVA 343
Query: 186 AFSSSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRA 245
AF+SSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRA
Sbjct: 344 AFASSNLGDVSPNILGPRCINTGESCDNANSTCPIGGPSMCIAKGPGQDMFDSTQIIGRA 403
Query: 246 MYQRAKELYASASQEVTGPLASAHQWVDMTDVTVWLNSTHASKTCKPALGYSFAAGTIDG 305
MYQRAK SKTCKPALGYSFAAGTIDG
Sbjct: 404 MYQRAK-----------------------------------SKTCKPALGYSFAAGTIDG 428
Query: 306 VGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVD 365
VGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVD
Sbjct: 429 VGGLNFTQGKTEGDPFWDTIRDQILGKPSEEIKECHKPKPILLHTGELSKPHPWHPDIVD 488
Query: 366 VQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTY 425
VQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTY
Sbjct: 489 VQIITLGSLAITAIPGEFTTMSGRRLREAVQAEFASHGMQNMTVVISGLCNVYTHYITTY 548
Query: 426 EEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIP 485
EEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIP
Sbjct: 549 EEYQAQRYEAASTIYGPHTLSAYIQLFRNLAKAIATDTVANLSRGPEPPFFKQLIVPLIP 608
Query: 486 SIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQNHQTFLTVEKYEATS 545
SIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQ HQTFLTVEKYEATS
Sbjct: 609 SIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLTVEKYEATS 668
Query: 546 TSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPA 605
TSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPA
Sbjct: 669 TSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNRKQDILKPA 728
Query: 606 VILSFEGTSPAFEVVTI 622
VILSFEGTSPAFEVVTI
Sbjct: 729 VILSFEGTSPAFEVVTI 745
>gi|118442845 N-acylsphingosine amidohydrolase (non-lysosomal
ceramidase) 2B [Homo sapiens]
Length = 165
Score = 284 bits (726), Expect = 2e-76
Identities = 136/145 (93%), Positives = 140/145 (96%)
Query: 478 QLIVPLIPSIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQNHQTFLT 537
+ ++ L+ IVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQ HQTFLT
Sbjct: 21 ETLLRLLLRIVDRAPKGRTFGDVLQPAKPEYRVGEVAEVIFVGANPKNSVQNQTHQTFLT 80
Query: 538 VEKYEATSTSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNR 597
VEKYEATSTSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNR
Sbjct: 81 VEKYEATSTSWQIVCNDASWETRFYWHKGLLGLSNATVEWHIPDTAQPGIYRIRYFGHNR 140
Query: 598 KQDILKPAVILSFEGTSPAFEVVTI 622
KQDILKPAVILSFEGTSPAFEVVTI
Sbjct: 141 KQDILKPAVILSFEGTSPAFEVVTI 165
>gi|156766054 PNMA-like 1 isoform b [Homo sapiens]
Length = 378
Score = 32.0 bits (71), Expect = 1.7
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 455 LAKAIATDTVANLSRGPEPPFFKQLIVPLIPSIVDRAPKGRTFGDVLQPAKPEYRVGEVA 514
++K +A + + + RG E + L+V IP +A T VL P P YRV +
Sbjct: 1 MSKTMAMNLLEDWCRGMEVDIHRSLLVTGIPEDCGQAEIEETLNGVLSPLGP-YRV--LN 57
Query: 515 EVIFVGANPKNSVQNQNHQTFLTV--EKYEATSTSWQIVCNDASWETRF 561
++ N K ++ L+ ++ W++VC D + + F
Sbjct: 58 KIFVREENVKAALIEVGEGVNLSTIPREFPGRGGVWRVVCRDPTQDAEF 106
>gi|39780597 PNMA-like 1 isoform a [Homo sapiens]
Length = 439
Score = 32.0 bits (71), Expect = 1.7
Identities = 26/109 (23%), Positives = 47/109 (43%), Gaps = 5/109 (4%)
Query: 455 LAKAIATDTVANLSRGPEPPFFKQLIVPLIPSIVDRAPKGRTFGDVLQPAKPEYRVGEVA 514
++K +A + + + RG E + L+V IP +A T VL P P YRV +
Sbjct: 1 MSKTMAMNLLEDWCRGMEVDIHRSLLVTGIPEDCGQAEIEETLNGVLSPLGP-YRV--LN 57
Query: 515 EVIFVGANPKNSVQNQNHQTFLTV--EKYEATSTSWQIVCNDASWETRF 561
++ N K ++ L+ ++ W++VC D + + F
Sbjct: 58 KIFVREENVKAALIEVGEGVNLSTIPREFPGRGGVWRVVCRDPTQDAEF 106
>gi|4505245 mannose receptor C type 1 precursor [Homo sapiens]
Length = 1456
Score = 31.6 bits (70), Expect = 2.3
Identities = 15/41 (36%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 526 SVQNQNHQTFLTVEKYEATSTSWQIVCNDASWETRFYWHKG 566
S+QN+ Q FLT ++T ++W + ND + E F W G
Sbjct: 986 SIQNEKEQAFLTYHMKDSTFSAWTGL-NDVNSEHTFLWTDG 1025
>gi|57546917 mannose receptor, C type 1-like 1 [Homo sapiens]
Length = 1456
Score = 31.6 bits (70), Expect = 2.3
Identities = 15/41 (36%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 526 SVQNQNHQTFLTVEKYEATSTSWQIVCNDASWETRFYWHKG 566
S+QN+ Q FLT ++T ++W + ND + E F W G
Sbjct: 986 SIQNEKEQAFLTYHMKDSTFSAWTGL-NDVNSEHTFLWTDG 1025
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,951,167
Number of Sequences: 37866
Number of extensions: 1148611
Number of successful extensions: 2334
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2329
Number of HSP's gapped (non-prelim): 8
length of query: 622
length of database: 18,247,518
effective HSP length: 108
effective length of query: 514
effective length of database: 14,157,990
effective search space: 7277206860
effective search space used: 7277206860
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.