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Search of human proteins with 13994341
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13994341 solute carrier family 25 member 2 [Homo sapiens]
(301 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13994341 solute carrier family 25 member 2 [Homo sapiens] 603 e-173
gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens] 535 e-152
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 153 2e-37
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 130 1e-30
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 130 2e-30
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 118 7e-27
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 100 2e-21
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 100 2e-21
gi|116235466 solute carrier family 25, member 45 isoform b [Homo... 98 1e-20
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 97 2e-20
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 97 2e-20
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 97 2e-20
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 93 3e-19
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 84 1e-16
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 84 2e-16
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 84 2e-16
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 84 2e-16
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 84 2e-16
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 84 2e-16
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 84 2e-16
gi|27544933 solute carrier family 25, member 16 [Homo sapiens] 82 6e-16
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 82 8e-16
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 81 1e-15
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 81 1e-15
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 81 1e-15
gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 79 6e-15
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 78 8e-15
gi|149274607 solute carrier family 25, member 41 [Homo sapiens] 78 8e-15
gi|13899342 solute carrier [Homo sapiens] 77 2e-14
gi|4505775 solute carrier family 25 member 3 isoform b precursor... 76 3e-14
>gi|13994341 solute carrier family 25 member 2 [Homo sapiens]
Length = 301
Score = 603 bits (1554), Expect = e-173
Identities = 301/301 (100%), Positives = 301/301 (100%)
Query: 1 MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGL 60
MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGL
Sbjct: 1 MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGL 60
Query: 61 RGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFA 120
RGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFA
Sbjct: 61 RGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFA 120
Query: 121 ALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQE 180
ALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQE
Sbjct: 121 ALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQE 180
Query: 181 VPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVL 240
VPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVL
Sbjct: 181 VPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVL 240
Query: 241 SMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEA 300
SMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEA
Sbjct: 241 SMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEA 300
Query: 301 Y 301
Y
Sbjct: 301 Y 301
>gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
Length = 301
Score = 535 bits (1379), Expect = e-152
Identities = 263/301 (87%), Positives = 279/301 (92%)
Query: 1 MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGL 60
MKS P IQAAIDLTAGAAGGTACVLTGQPFDT+KVKMQTFPDLY+GLTDC LKTY+QVG
Sbjct: 1 MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGF 60
Query: 61 RGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFA 120
RGFYKGT PAL+A +AENSVLFMCYGFCQQ VRKVAG+DKQAKLSDLQ AAAGSFASAFA
Sbjct: 61 RGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFA 120
Query: 121 ALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQE 180
AL LCPTELVKCRLQTMYEME SGKIAKS NT+WSV+K IL+KDGPLGFYHGLSSTLL+E
Sbjct: 121 ALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLRE 180
Query: 181 VPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVL 240
VPGYFFFFGGYELSRSFFASGRSKDELGPV LMLSGGV GICLWL V+PVDCIKSRIQVL
Sbjct: 181 VPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVL 240
Query: 241 SMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEA 300
SM GKQAGFI T ++VV+NEGI ALYSGLK TMIRA PANGALF+AYEYSRK+MM QLEA
Sbjct: 241 SMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEA 300
Query: 301 Y 301
Y
Sbjct: 301 Y 301
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 153 bits (387), Expect = 2e-37
Identities = 96/291 (32%), Positives = 144/291 (49%), Gaps = 17/291 (5%)
Query: 12 DLTAGAAGGTACVLTGQPFDTIKVKMQTFPD-------LYKGLTDCFLKTYAQVGLRGFY 64
+L AG GG V G P DT+KV++QT P +Y G DCF KT + G+ G Y
Sbjct: 13 NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
Query: 65 KGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALAL 124
+G ++ +V F +G ++ +K + LS Q AAG + F +
Sbjct: 73 RGMAAPIIGVTPMFAVCFFGFGLGKKLQQK----HPEDVLSYPQLFAAGMLSGVFTTGIM 128
Query: 125 CPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGY 184
P E +KC LQ ++ S +K T+ K + ++ G G Y G TL+++VP
Sbjct: 129 TPGERIKCLLQ----IQASSGESKYTGTL-DCAKKLYQEFGIRGIYKGTVLTLMRDVPAS 183
Query: 185 FFFFGGYELSRSFFA-SGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMY 243
+F YE ++ F G+ EL ++++GG+AGI W V P D +KSR Q
Sbjct: 184 GMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPG 243
Query: 244 GKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMM 294
GF L ++R+EG+ +LY G A MIRA PAN A F+ +E + K +
Sbjct: 244 KYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFL 294
Score = 64.3 bits (155), Expect = 1e-10
Identities = 47/197 (23%), Positives = 90/197 (45%), Gaps = 5/197 (2%)
Query: 99 DKQAKLSDLQTAAAGSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVK 158
D+ +S L+ AG F P + VK RLQT + G+ ++ + +
Sbjct: 3 DQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQ-PPSLPGQ-PPMYSGTFDCFR 60
Query: 159 GILKKDGPLGFYHGLSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGV 218
L ++G G Y G+++ ++ P + F G+ L + +D L L +G +
Sbjct: 61 KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKK-LQQKHPEDVLSYPQLFAAGML 119
Query: 219 AGICLWLVVFPVDCIKSRIQVLSMYG--KQAGFIGTLLSVVRNEGIVALYSGLKATMIRA 276
+G+ ++ P + IK +Q+ + G K G + + + GI +Y G T++R
Sbjct: 120 SGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRD 179
Query: 277 IPANGALFVAYEYSRKM 293
+PA+G F+ YE+ + +
Sbjct: 180 VPASGMYFMTYEWLKNI 196
Score = 50.1 bits (118), Expect = 2e-06
Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 5/98 (5%)
Query: 207 LGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVL--SMYGKQAGFIGT---LLSVVRNEG 261
+ P+ +L+GG G+CL V P+D +K R+Q S+ G+ + GT + EG
Sbjct: 8 ISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREG 67
Query: 262 IVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLE 299
I LY G+ A +I P F + +K+ K E
Sbjct: 68 ITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPE 105
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 130 bits (327), Expect = 1e-30
Identities = 96/281 (34%), Positives = 136/281 (48%), Gaps = 22/281 (7%)
Query: 10 AIDLTAGAAGGTACVLTGQPFDTIKVKMQ---TFPDLYKGLTDCFLKTYAQVGLRGFYKG 66
A+D AG AGG A VL G PFDT+KV++Q Y+G CF Q + G YKG
Sbjct: 2 ALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKG 61
Query: 67 TGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCP 126
G LM N+++F G + G D S L AG+ A A + CP
Sbjct: 62 LGSPLMGLTFINALVFGVQG----NTLRALGHD-----SPLNQFLAGAAAGAIQCVICCP 112
Query: 127 TELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFF 186
EL K RLQ ++ +G A+++ + I +G G G+ STLL+E P +
Sbjct: 113 MELAKTRLQ----LQDAGP-ARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGV 167
Query: 187 FFGGYE-LSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYG- 244
+F Y+ L+R+ D L L+L+GG +GI WL +PVD +KSR+Q + G
Sbjct: 168 YFLTYDALTRAL--GCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGA 225
Query: 245 -KQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALF 284
+ G + + R EG GL +T++RA P N A F
Sbjct: 226 PRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATF 266
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 130 bits (326), Expect = 2e-30
Identities = 83/282 (29%), Positives = 135/282 (47%), Gaps = 8/282 (2%)
Query: 12 DLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGTGPAL 71
+ AG G ++ G PFDT+KV++QT Y+G+ DC +K Y L GF+KG +
Sbjct: 5 EFVAGWISGALGLVLGHPFDTVKVRLQT-QTTYRGIVDCMVKIYRHESLLGFFKGMSFPI 63
Query: 72 MAYVAENSVLFMCYGFCQQFVRKVAGMDKQAK-LSDLQTAAAGSFASAFAALALCPTELV 130
+ NSVLF Y + + +++A+ S + AG A L P +L+
Sbjct: 64 ASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLI 123
Query: 131 KCRLQTMYE-MEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFG 189
K RLQ E G + I +++GP G + G + L++ P +F
Sbjct: 124 KVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFI 183
Query: 190 GYE-LSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGK-QA 247
YE L R + G++ ++++GG AGI W+ P+D IKSR+Q+ + +
Sbjct: 184 TYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQ 240
Query: 248 GFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEY 289
G + ++S +R EG+ + G+ RA P N F++YEY
Sbjct: 241 GMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
Score = 40.4 bits (93), Expect = 0.002
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 3/87 (3%)
Query: 4 GPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQ---TFPDLYKGLTDCFLKTYAQVGL 60
G +A L AG G A + P D IK +MQ +Y+G+ DC + + Q GL
Sbjct: 196 GQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGL 255
Query: 61 RGFYKGTGPALMAYVAENSVLFMCYGF 87
F++G N+V F+ Y +
Sbjct: 256 GVFFRGVTINSARAFPVNAVTFLSYEY 282
Score = 36.2 bits (82), Expect = 0.036
Identities = 18/79 (22%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 209 PVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSG 268
PV ++G ++G ++ P D +K R+Q + Y G + ++ + R+E ++ + G
Sbjct: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTTY---RGIVDCMVKIYRHESLLGFFKG 58
Query: 269 LKATMIRAIPANGALFVAY 287
+ + N LF Y
Sbjct: 59 MSFPIASIAVVNSVLFGVY 77
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 118 bits (295), Expect = 7e-27
Identities = 85/300 (28%), Positives = 138/300 (46%), Gaps = 25/300 (8%)
Query: 11 IDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGTGPA 70
+D AGA GG V G P DT+KV++QT P Y G+ C TY + + GFY+G
Sbjct: 1 MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEPK-YTGIWHCVRDTYHRERVWGFYRGLSLP 59
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELV 130
+ +SV F Y C + ++ + AK + +G + PTE+
Sbjct: 60 VCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEVA 119
Query: 131 KCRLQTMYE-------MEMSGKIA-------------KSHNTIWSVVKGILKKDGPLGFY 170
K RLQT + + SG +A + + + +++G G Y
Sbjct: 120 KVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLY 179
Query: 171 HGLSSTLLQEVPGYFFFFGGYELSRSFFA-SGRSKDELGPVHLMLSGGVAGICLWLVVFP 229
G S+ +L++ + +F Y + + + +G S+ ++ V +++GG AG+ W V P
Sbjct: 180 KGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGV--LVAGGCAGVLAWAVATP 237
Query: 230 VDCIKSRIQVLSM-YGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
+D IKSR+Q + G + +++ VR EG L+ GL RA P N +FVAYE
Sbjct: 238 MDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYE 297
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 100 bits (248), Expect = 2e-21
Identities = 81/285 (28%), Positives = 128/285 (44%), Gaps = 32/285 (11%)
Query: 15 AGAAGGTACVLTGQPFDTIKVKMQTFPD--------LYKGLTDCFLKTYAQVGLRGFYKG 66
AGA G TA P D +K +MQ +YK DCF K G G Y+G
Sbjct: 338 AGAVGATAVY----PIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRG 393
Query: 67 TGPALMAYVAENSVLFMCYGFCQ-QFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALC 125
P L+ E ++ F + +F+ K + A++ AG A +
Sbjct: 394 LLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEI------LAGGCAGGSQVIFTN 447
Query: 126 PTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYF 185
P E+VK RLQ E+ +++ SVV+ + G G Y G + L+++P
Sbjct: 448 PLEIVKIRLQVAGEITTGPRVSAL-----SVVRDL----GFFGIYKGAKACFLRDIPFSA 498
Query: 186 FFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGK 245
+F Y ++ FA+ ++ P L+L+G +AG+ +V P D IK+R+QV + G+
Sbjct: 499 IYFPCYAHVKASFAN--EDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQ 556
Query: 246 --QAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
+G I ++R EG AL+ G A + R+ P G + YE
Sbjct: 557 TTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 601
Score = 62.8 bits (151), Expect = 4e-10
Identities = 49/201 (24%), Positives = 88/201 (43%), Gaps = 19/201 (9%)
Query: 2 KSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLR 61
K G AA L G AGG+ + T P + +K+++Q ++ G L +G
Sbjct: 422 KDGSVPLAAEILAGGCAGGSQVIFTN-PLEIVKIRLQVAGEITTGPRVSALSVVRDLGFF 480
Query: 62 GFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAA 121
G YKG + + +++ F CY K + ++ ++S AG+ A AA
Sbjct: 481 GIYKGAKACFLRDIPFSAIYFPCYAHV-----KASFANEDGQVSPGSLLLAGAIAGMPAA 535
Query: 122 LALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVV----KGILKKDGPLGFYHGLSSTL 177
+ P +++K RLQ A++ T +S V + IL+++GP + G + +
Sbjct: 536 SLVTPADVIKTRLQV---------AARAGQTTYSGVIDCFRKILREEGPKALWKGAGARV 586
Query: 178 LQEVPGYFFFFGGYELSRSFF 198
+ P + YEL + +F
Sbjct: 587 FRSSPQFGVTLLTYELLQRWF 607
Score = 61.2 bits (147), Expect = 1e-09
Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 23/186 (12%)
Query: 113 GSFASAFAALALCPTELVKCRLQTMYEM-EMSGKIAKSHNTIWSVVKGILKKDGPLGFYH 171
GS A A A A+ P +LVK R+Q G++ ++ + K +L+ +G G Y
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNS--FDCFKKVLRYEGFFGLYR 392
Query: 172 GLSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHL---MLSGGVAGICLWLVVF 228
GL LL P +L+ + F + + G V L +L+GG AG +
Sbjct: 393 GLLPQLLGVAPEK-----AIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTN 447
Query: 229 PVDCIKSRIQVLSMYGKQAGFIGT-----LLSVVRNEGIVALYSGLKATMIRAIPANGAL 283
P++ +K R+QV AG I T LSVVR+ G +Y G KA +R IP +
Sbjct: 448 PLEIVKIRLQV-------AGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIY 500
Query: 284 FVAYEY 289
F Y +
Sbjct: 501 FPCYAH 506
Score = 36.2 bits (82), Expect = 0.036
Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 12/89 (13%)
Query: 216 GGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLL---------SVVRNEGIVALY 266
G VAG V+P+D +K+R+Q G F+G L+ V+R EG LY
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGS---FVGELMYKNSFDCFKKVLRYEGFFGLY 391
Query: 267 SGLKATMIRAIPANGALFVAYEYSRKMMM 295
GL ++ P ++ R M
Sbjct: 392 RGLLPQLLGVAPEKAIKLTVNDFVRDKFM 420
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 100 bits (248), Expect = 2e-21
Identities = 81/285 (28%), Positives = 128/285 (44%), Gaps = 32/285 (11%)
Query: 15 AGAAGGTACVLTGQPFDTIKVKMQTFPD--------LYKGLTDCFLKTYAQVGLRGFYKG 66
AGA G TA P D +K +MQ +YK DCF K G G Y+G
Sbjct: 339 AGAVGATAVY----PIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRG 394
Query: 67 TGPALMAYVAENSVLFMCYGFCQ-QFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALC 125
P L+ E ++ F + +F+ K + A++ AG A +
Sbjct: 395 LLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEI------LAGGCAGGSQVIFTN 448
Query: 126 PTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYF 185
P E+VK RLQ E+ +++ SVV+ + G G Y G + L+++P
Sbjct: 449 PLEIVKIRLQVAGEITTGPRVSAL-----SVVRDL----GFFGIYKGAKACFLRDIPFSA 499
Query: 186 FFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGK 245
+F Y ++ FA+ ++ P L+L+G +AG+ +V P D IK+R+QV + G+
Sbjct: 500 IYFPCYAHVKASFAN--EDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQ 557
Query: 246 --QAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
+G I ++R EG AL+ G A + R+ P G + YE
Sbjct: 558 TTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 602
Score = 62.8 bits (151), Expect = 4e-10
Identities = 49/201 (24%), Positives = 88/201 (43%), Gaps = 19/201 (9%)
Query: 2 KSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLR 61
K G AA L G AGG+ + T P + +K+++Q ++ G L +G
Sbjct: 423 KDGSVPLAAEILAGGCAGGSQVIFTN-PLEIVKIRLQVAGEITTGPRVSALSVVRDLGFF 481
Query: 62 GFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAA 121
G YKG + + +++ F CY K + ++ ++S AG+ A AA
Sbjct: 482 GIYKGAKACFLRDIPFSAIYFPCYAHV-----KASFANEDGQVSPGSLLLAGAIAGMPAA 536
Query: 122 LALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVV----KGILKKDGPLGFYHGLSSTL 177
+ P +++K RLQ A++ T +S V + IL+++GP + G + +
Sbjct: 537 SLVTPADVIKTRLQV---------AARAGQTTYSGVIDCFRKILREEGPKALWKGAGARV 587
Query: 178 LQEVPGYFFFFGGYELSRSFF 198
+ P + YEL + +F
Sbjct: 588 FRSSPQFGVTLLTYELLQRWF 608
Score = 61.2 bits (147), Expect = 1e-09
Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 23/186 (12%)
Query: 113 GSFASAFAALALCPTELVKCRLQTMYEM-EMSGKIAKSHNTIWSVVKGILKKDGPLGFYH 171
GS A A A A+ P +LVK R+Q G++ ++ + K +L+ +G G Y
Sbjct: 336 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNS--FDCFKKVLRYEGFFGLYR 393
Query: 172 GLSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHL---MLSGGVAGICLWLVVF 228
GL LL P +L+ + F + + G V L +L+GG AG +
Sbjct: 394 GLLPQLLGVAPEK-----AIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTN 448
Query: 229 PVDCIKSRIQVLSMYGKQAGFIGT-----LLSVVRNEGIVALYSGLKATMIRAIPANGAL 283
P++ +K R+QV AG I T LSVVR+ G +Y G KA +R IP +
Sbjct: 449 PLEIVKIRLQV-------AGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIY 501
Query: 284 FVAYEY 289
F Y +
Sbjct: 502 FPCYAH 507
Score = 36.6 bits (83), Expect = 0.028
Identities = 34/121 (28%), Positives = 48/121 (39%), Gaps = 23/121 (19%)
Query: 192 ELSRSFFASGRSKDELGPVHLMLS--------GGVAGICLWLVVFPVDCIKSRIQVLSMY 243
E R ASG D PV L ++ G VAG V+P+D +K+R+Q
Sbjct: 307 EAQRQQKASG---DSARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRST 363
Query: 244 GKQAGFIGTLL---------SVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMM 294
G F+G L+ V+R EG LY GL ++ P ++ R
Sbjct: 364 GS---FVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKF 420
Query: 295 M 295
M
Sbjct: 421 M 421
>gi|116235466 solute carrier family 25, member 45 isoform b [Homo
sapiens]
Length = 246
Score = 97.8 bits (242), Expect = 1e-20
Identities = 67/242 (27%), Positives = 111/242 (45%), Gaps = 7/242 (2%)
Query: 52 LKTYAQVGLRGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKL-SDLQTA 110
+K Y L GF+KG + + NSVLF Y + + +++A+ S +
Sbjct: 2 VKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIF 61
Query: 111 AAGSFASAFAALALCPTELVKCRLQTMYEMEMS-GKIAKSHNTIWSVVKGILKKDGPLGF 169
AG A L P +L+K RLQ E G + I +++GP G
Sbjct: 62 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 121
Query: 170 YHGLSSTLLQEVPGYFFFFGGYE-LSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVF 228
+ G + L++ P +F YE L R + G++ ++++GG AGI W+
Sbjct: 122 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAAT 178
Query: 229 PVDCIKSRIQVLSMYGK-QAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAY 287
P+D IKSR+Q+ + + G + ++S +R EG+ + G+ RA P N F++Y
Sbjct: 179 PLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSY 238
Query: 288 EY 289
EY
Sbjct: 239 EY 240
Score = 50.4 bits (119), Expect = 2e-06
Identities = 43/189 (22%), Positives = 75/189 (39%), Gaps = 23/189 (12%)
Query: 15 AGAAGGTACVLTGQPFDTIKVKMQ----------TFPDLYKGLTDCFLKTYAQVGLRGFY 64
AG GG PFD IKV++Q + P Y+G C + + G RG +
Sbjct: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
Query: 65 KGTGPALMAYVAENSVLFMCY-GFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALA 123
+G + + F+ Y G C+Q+ + S AG FA + +A
Sbjct: 123 RGAWALTLRDTPTVGIYFITYEGLCRQYT------PEGQNPSSATVLVAGGFAGIASWVA 176
Query: 124 LCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPG 183
P +++K R M+M G + + + + ++++G F+ G++ + P
Sbjct: 177 ATPLDMIKSR------MQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPV 230
Query: 184 YFFFFGGYE 192
F YE
Sbjct: 231 NAVTFLSYE 239
Score = 40.4 bits (93), Expect = 0.002
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 3/87 (3%)
Query: 4 GPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFP---DLYKGLTDCFLKTYAQVGL 60
G +A L AG G A + P D IK +MQ +Y+G+ DC + + Q GL
Sbjct: 154 GQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGL 213
Query: 61 RGFYKGTGPALMAYVAENSVLFMCYGF 87
F++G N+V F+ Y +
Sbjct: 214 GVFFRGVTINSARAFPVNAVTFLSYEY 240
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 97.1 bits (240), Expect = 2e-20
Identities = 73/288 (25%), Positives = 128/288 (44%), Gaps = 19/288 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLT--DCFLKTYAQVGLRGFYKGTGPA 70
L AG G + P D +K+ MQ + F + + G+R ++G G
Sbjct: 198 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTN 257
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELV 130
++ E +V F Y +Q+ + + ++ K+ + +GS A A A + P E++
Sbjct: 258 VIKIAPETAVKFWAY---EQYKKLLT--EEGQKIGTFERFISGSMAGATAQTFIYPMEVM 312
Query: 131 KCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGG 190
K RL + SG I+ K ILK +G FY G LL +P
Sbjct: 313 KTRLAVGKTGQYSG--------IYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAV 364
Query: 191 YELSRSFFASGRSKDELGPVHLML--SGGVAGICLWLVVFPVDCIKSRIQVLSMY--GKQ 246
YEL +S++ +KD + P ++L G ++ C L +P+ +++R+Q +M Q
Sbjct: 365 YELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQ 424
Query: 247 AGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMM 294
+G ++ EGI LY G+ ++ +PA G +V YE ++ +
Sbjct: 425 LNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 472
Score = 42.0 bits (97), Expect = 7e-04
Identities = 23/85 (27%), Positives = 41/85 (48%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+L+GG+AG P+D +K +QV + G +V+ GI +L+ G
Sbjct: 198 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTN 257
Query: 273 MIRAIPANGALFVAYEYSRKMMMKQ 297
+I+ P F AYE +K++ ++
Sbjct: 258 VIKIAPETAVKFWAYEQYKKLLTEE 282
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 97.1 bits (240), Expect = 2e-20
Identities = 73/288 (25%), Positives = 128/288 (44%), Gaps = 19/288 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLT--DCFLKTYAQVGLRGFYKGTGPA 70
L AG G + P D +K+ MQ + F + + G+R ++G G
Sbjct: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTN 238
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELV 130
++ E +V F Y +Q+ + + ++ K+ + +GS A A A + P E++
Sbjct: 239 VIKIAPETAVKFWAY---EQYKKLLT--EEGQKIGTFERFISGSMAGATAQTFIYPMEVM 293
Query: 131 KCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGG 190
K RL + SG I+ K ILK +G FY G LL +P
Sbjct: 294 KTRLAVGKTGQYSG--------IYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAV 345
Query: 191 YELSRSFFASGRSKDELGPVHLML--SGGVAGICLWLVVFPVDCIKSRIQVLSMY--GKQ 246
YEL +S++ +KD + P ++L G ++ C L +P+ +++R+Q +M Q
Sbjct: 346 YELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQ 405
Query: 247 AGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMM 294
+G ++ EGI LY G+ ++ +PA G +V YE ++ +
Sbjct: 406 LNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 453
Score = 42.0 bits (97), Expect = 7e-04
Identities = 23/85 (27%), Positives = 41/85 (48%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+L+GG+AG P+D +K +QV + G +V+ GI +L+ G
Sbjct: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTN 238
Query: 273 MIRAIPANGALFVAYEYSRKMMMKQ 297
+I+ P F AYE +K++ ++
Sbjct: 239 VIKIAPETAVKFWAYEQYKKLLTEE 263
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 96.7 bits (239), Expect = 2e-20
Identities = 75/292 (25%), Positives = 124/292 (42%), Gaps = 28/292 (9%)
Query: 8 QAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPD--------LYKGLTDCFLKTYAQVG 59
++A T G+ G P D +K +MQ +YK DCF K G
Sbjct: 325 ESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEG 384
Query: 60 LRGFYKGTGPALMAYVAENSVLFMCYGFCQ-QFVRKVAGMDKQAKLSDLQTAAAGSFASA 118
G Y+G P L+ E ++ F + +F R+ + A++ AG A
Sbjct: 385 FFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEV------LAGGCAGG 438
Query: 119 FAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLL 178
+ P E+VK RLQ E+ +++ + +L+ G G Y G + L
Sbjct: 439 SQVIFTNPLEIVKIRLQVAGEITTGPRVSALN---------VLRDLGIFGLYKGAKACFL 489
Query: 179 QEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQ 238
+++P +F Y + A +G ++L+ +G +AG+ +V P D IK+R+Q
Sbjct: 490 RDIPFSAIYFPVYAHCKLLLAD--ENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQ 547
Query: 239 VLSMYGK--QAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
V + G+ +G I ++R EG A + G A + R+ P G V YE
Sbjct: 548 VAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYE 599
Score = 69.3 bits (168), Expect = 4e-12
Identities = 48/190 (25%), Positives = 87/190 (45%), Gaps = 19/190 (10%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGTGPALM 72
L G AGG+ + T P + +K+++Q ++ G L +G+ G YKG +
Sbjct: 431 LAGGCAGGSQVIFTN-PLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFL 489
Query: 73 AYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELVKC 132
+ +++ F Y C K+ D+ + L AAG+ A AA + P +++K
Sbjct: 490 RDIPFSAIYFPVYAHC-----KLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKT 544
Query: 133 RLQTMYEMEMSGKIAKSHNTIWSVV----KGILKKDGPLGFYHGLSSTLLQEVPGYFFFF 188
RLQ A++ T +S V + IL+++GP F+ G ++ + + P +
Sbjct: 545 RLQV---------AARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTL 595
Query: 189 GGYELSRSFF 198
YEL + +F
Sbjct: 596 VTYELLQRWF 605
Score = 33.1 bits (74), Expect = 0.31
Identities = 23/82 (28%), Positives = 33/82 (40%), Gaps = 6/82 (7%)
Query: 216 GGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFI------GTLLSVVRNEGIVALYSGL 269
G VAG V+P+D +K+R+Q G G + V+R EG LY GL
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL 392
Query: 270 KATMIRAIPANGALFVAYEYSR 291
+I P ++ R
Sbjct: 393 IPQLIGVAPEKAIKLTVNDFVR 414
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 92.8 bits (229), Expect = 3e-19
Identities = 75/292 (25%), Positives = 128/292 (43%), Gaps = 27/292 (9%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFP------DLYKGLTDCFLKTYAQVGLRGFYKG 66
L AGA G P D +KV MQ ++ GL L+ G+R ++G
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEG----GIRSLWRG 244
Query: 67 TGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCP 126
G ++ E+++ FM Y +Q R + G +Q L + AGS A A A + P
Sbjct: 245 NGINVLKIAPESAIKFMAY---EQIKRAILG--QQETLHVQERFVAGSLAGATAQTIIYP 299
Query: 127 TELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFF 186
E++K RL + G + + IL+++GP FY G +L +P
Sbjct: 300 MEVLKTRLTLRRTGQYKGLL--------DCARRILEREGPRAFYRGYLPNVLGIIPYAGI 351
Query: 187 FFGGYELSRSFFASGRSKDELGPVHLML--SGGVAGICLWLVVFPVDCIKSRIQVLSMY- 243
YE ++++ S D P L+L G ++ C + +P+ +++R+Q +
Sbjct: 352 DLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIE 411
Query: 244 -GKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMM 294
G Q +G L ++ EG+ LY G+ ++ IPA +V YE ++ +
Sbjct: 412 GGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQAL 463
Score = 42.7 bits (99), Expect = 4e-04
Identities = 42/202 (20%), Positives = 85/202 (42%), Gaps = 16/202 (7%)
Query: 100 KQAKLSDL--QTAAAGSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHN-TIWSV 156
KQ KL+ + + AG+ A A + P + +K +Q +K++ I
Sbjct: 177 KQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQV--------HASKTNRLNILGG 228
Query: 157 VKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGGYE-LSRSFFASGRSKDELGPVHLMLS 215
++ ++ + G + G +L+ P F YE + R+ ++ L ++
Sbjct: 229 LRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQ---QETLHVQERFVA 285
Query: 216 GGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIR 275
G +AG +++P++ +K+R+ L G+ G + ++ EG A Y G ++
Sbjct: 286 GSLAGATAQTIIYPMEVLKTRL-TLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLG 344
Query: 276 AIPANGALFVAYEYSRKMMMKQ 297
IP G YE + ++Q
Sbjct: 345 IIPYAGIDLAVYETLKNWWLQQ 366
Score = 40.0 bits (92), Expect = 0.003
Identities = 24/87 (27%), Positives = 45/87 (51%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+++G VAG P+D +K +QV + + +G L S+V GI +L+ G
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGIN 248
Query: 273 MIRAIPANGALFVAYEYSRKMMMKQLE 299
+++ P + F+AYE ++ ++ Q E
Sbjct: 249 VLKIAPESAIKFMAYEQIKRAILGQQE 275
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 84.3 bits (207), Expect = 1e-16
Identities = 84/301 (27%), Positives = 135/301 (44%), Gaps = 39/301 (12%)
Query: 8 QAAIDLTAGAAGGTACVLTGQPFDTIKVKMQ-----TFPDLYKGLTDCFLKTYAQVGLRG 62
+A+ + AG + G + P D +K + Q T P+ YK L D F + GL G
Sbjct: 12 EASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFG 71
Query: 63 FYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQT-AAAGSFASAFAA 121
FYKG P ++A + +V F + +Q+ +K+ G LS T A AG + A
Sbjct: 72 FYKGILPPILAETPKRAVKFFTF---EQY-KKLLG---YVSLSPALTFAIAGLGSGLTEA 124
Query: 122 LALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKD--GPLGFYHGLSSTLLQ 179
+ + P E+VK LQ A+ +T+ + I+KK+ G G GL++TL +
Sbjct: 125 IVVNPFEVVKVGLQA-----NRNTFAEQPSTV-GYARQIIKKEGWGLQGLNKGLTATLGR 178
Query: 180 EVPGYFFFFGGYELSRSFFASGRS-------KDELGPVHLMLSGGVAGICLWLVVFPVDC 232
+FG Y ++ + K +G +LSG +A + + P D
Sbjct: 179 HGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIG----LLSGTIASV----INIPFDV 230
Query: 233 IKSRIQVLSMYGKQAGF---IGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEY 289
KSRIQ + + T+ +V + EGI+ALY GL ++R P + + YEY
Sbjct: 231 AKSRIQGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEY 290
Query: 290 S 290
+
Sbjct: 291 T 291
Score = 37.7 bits (86), Expect = 0.013
Identities = 42/189 (22%), Positives = 77/189 (40%), Gaps = 15/189 (7%)
Query: 15 AGAAGGTACVLTGQPFDTIKVKMQTFPDLYK------GLTDCFLKTYAQVGLRGFYKGTG 68
AG G + PF+ +KV +Q + + G +K GL+G KG
Sbjct: 115 AGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGW-GLQGLNKG-- 171
Query: 69 PALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTE 128
L A + + V M Y V+ + ++K L + G + A++ P +
Sbjct: 172 --LTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFD 229
Query: 129 LVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFF 188
+ K R+Q + G+I + T + + + +++G L Y GL +++ PG
Sbjct: 230 VAKSRIQG--PQPVPGEI--KYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVML 285
Query: 189 GGYELSRSF 197
YE + S+
Sbjct: 286 LVYEYTYSW 294
Score = 35.4 bits (80), Expect = 0.062
Identities = 17/85 (20%), Positives = 39/85 (45%), Gaps = 3/85 (3%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMY---GKQAGFIGTLLSVVRNEGIVALYSGL 269
+++GG AG+ ++ P+D +K+R Q+ + + + + EG+ Y G+
Sbjct: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGI 76
Query: 270 KATMIRAIPANGALFVAYEYSRKMM 294
++ P F +E +K++
Sbjct: 77 LPPILAETPKRAVKFFTFEQYKKLL 101
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 83.6 bits (205), Expect = 2e-16
Identities = 69/282 (24%), Positives = 122/282 (43%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYK--GLTDCFLKTYAQVGLRGFYKGTGPA 70
L AG G P D +KV MQ G+ F + + G R ++G G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A ++ P E++
Sbjct: 250 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 304
Query: 131 KCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 305 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 356
Query: 191 YELSRSFFASGRSKDELGP--VHLMLSGGVAGICLWLVVFPVDCIKSRIQV-LSMYGKQA 247
YE ++ + + + P L+ G ++ C L +P+ +++R+Q S+ G
Sbjct: 357 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 416
Query: 248 GFIGTLLS-VVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
+ +L ++R EG LY GL ++ IPA +V YE
Sbjct: 417 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 458
Score = 39.7 bits (91), Expect = 0.003
Identities = 20/82 (24%), Positives = 41/82 (50%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+++GG AG P+D +K +QV + G +G ++R G +L+ G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 273 MIRAIPANGALFVAYEYSRKMM 294
+++ P + F+AYE ++++
Sbjct: 250 VLKIAPESAIKFMAYEQIKRLV 271
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 83.6 bits (205), Expect = 2e-16
Identities = 69/282 (24%), Positives = 122/282 (43%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYK--GLTDCFLKTYAQVGLRGFYKGTGPA 70
L AG G P D +KV MQ G+ F + + G R ++G G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A ++ P E++
Sbjct: 284 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 338
Query: 131 KCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 339 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 390
Query: 191 YELSRSFFASGRSKDELGP--VHLMLSGGVAGICLWLVVFPVDCIKSRIQV-LSMYGKQA 247
YE ++ + + + P L+ G ++ C L +P+ +++R+Q S+ G
Sbjct: 391 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 450
Query: 248 GFIGTLLS-VVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
+ +L ++R EG LY GL ++ IPA +V YE
Sbjct: 451 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 492
Score = 39.7 bits (91), Expect = 0.003
Identities = 20/82 (24%), Positives = 41/82 (50%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+++GG AG P+D +K +QV + G +G ++R G +L+ G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 273 MIRAIPANGALFVAYEYSRKMM 294
+++ P + F+AYE ++++
Sbjct: 284 VLKIAPESAIKFMAYEQIKRLV 305
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 83.6 bits (205), Expect = 2e-16
Identities = 69/282 (24%), Positives = 122/282 (43%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYK--GLTDCFLKTYAQVGLRGFYKGTGPA 70
L AG G P D +KV MQ G+ F + + G R ++G G
Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 269
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A ++ P E++
Sbjct: 270 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 324
Query: 131 KCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 325 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 376
Query: 191 YELSRSFFASGRSKDELGP--VHLMLSGGVAGICLWLVVFPVDCIKSRIQV-LSMYGKQA 247
YE ++ + + + P L+ G ++ C L +P+ +++R+Q S+ G
Sbjct: 377 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 436
Query: 248 GFIGTLLS-VVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
+ +L ++R EG LY GL ++ IPA +V YE
Sbjct: 437 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 478
Score = 39.7 bits (91), Expect = 0.003
Identities = 20/82 (24%), Positives = 41/82 (50%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+++GG AG P+D +K +QV + G +G ++R G +L+ G
Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 269
Query: 273 MIRAIPANGALFVAYEYSRKMM 294
+++ P + F+AYE ++++
Sbjct: 270 VLKIAPESAIKFMAYEQIKRLV 291
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 83.6 bits (205), Expect = 2e-16
Identities = 69/282 (24%), Positives = 122/282 (43%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYK--GLTDCFLKTYAQVGLRGFYKGTGPA 70
L AG G P D +KV MQ G+ F + + G R ++G G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A ++ P E++
Sbjct: 250 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 304
Query: 131 KCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 305 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 356
Query: 191 YELSRSFFASGRSKDELGP--VHLMLSGGVAGICLWLVVFPVDCIKSRIQV-LSMYGKQA 247
YE ++ + + + P L+ G ++ C L +P+ +++R+Q S+ G
Sbjct: 357 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 416
Query: 248 GFIGTLLS-VVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
+ +L ++R EG LY GL ++ IPA +V YE
Sbjct: 417 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 458
Score = 39.7 bits (91), Expect = 0.003
Identities = 20/82 (24%), Positives = 41/82 (50%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+++GG AG P+D +K +QV + G +G ++R G +L+ G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 273 MIRAIPANGALFVAYEYSRKMM 294
+++ P + F+AYE ++++
Sbjct: 250 VLKIAPESAIKFMAYEQIKRLV 271
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 83.6 bits (205), Expect = 2e-16
Identities = 69/282 (24%), Positives = 122/282 (43%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYK--GLTDCFLKTYAQVGLRGFYKGTGPA 70
L AG G P D +KV MQ G+ F + + G R ++G G
Sbjct: 87 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 146
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A ++ P E++
Sbjct: 147 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 201
Query: 131 KCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 202 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 253
Query: 191 YELSRSFFASGRSKDELGP--VHLMLSGGVAGICLWLVVFPVDCIKSRIQV-LSMYGKQA 247
YE ++ + + + P L+ G ++ C L +P+ +++R+Q S+ G
Sbjct: 254 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 313
Query: 248 GFIGTLLS-VVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
+ +L ++R EG LY GL ++ IPA +V YE
Sbjct: 314 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 355
Score = 39.7 bits (91), Expect = 0.003
Identities = 20/82 (24%), Positives = 41/82 (50%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+++GG AG P+D +K +QV + G +G ++R G +L+ G
Sbjct: 87 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 146
Query: 273 MIRAIPANGALFVAYEYSRKMM 294
+++ P + F+AYE ++++
Sbjct: 147 VLKIAPESAIKFMAYEQIKRLV 168
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 83.6 bits (205), Expect = 2e-16
Identities = 69/282 (24%), Positives = 122/282 (43%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYK--GLTDCFLKTYAQVGLRGFYKGTGPA 70
L AG G P D +KV MQ G+ F + + G R ++G G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A ++ P E++
Sbjct: 284 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 338
Query: 131 KCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 339 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 390
Query: 191 YELSRSFFASGRSKDELGP--VHLMLSGGVAGICLWLVVFPVDCIKSRIQV-LSMYGKQA 247
YE ++ + + + P L+ G ++ C L +P+ +++R+Q S+ G
Sbjct: 391 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 450
Query: 248 GFIGTLLS-VVRNEGIVALYSGLKATMIRAIPANGALFVAYE 288
+ +L ++R EG LY GL ++ IPA +V YE
Sbjct: 451 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 492
Score = 39.7 bits (91), Expect = 0.003
Identities = 20/82 (24%), Positives = 41/82 (50%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+++GG AG P+D +K +QV + G +G ++R G +L+ G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 273 MIRAIPANGALFVAYEYSRKMM 294
+++ P + F+AYE ++++
Sbjct: 284 VLKIAPESAIKFMAYEQIKRLV 305
>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
Length = 332
Score = 82.0 bits (201), Expect = 6e-16
Identities = 82/297 (27%), Positives = 120/297 (40%), Gaps = 30/297 (10%)
Query: 15 AGAAGGTACVLTGQPFDTIKVKMQTFPDLYK--GLTDCFLKTYAQVGLRGFYKGTGPALM 72
AG G T P D +KV +Q YK G+ + G G YKG G ++
Sbjct: 42 AGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMI 101
Query: 73 AYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELVKC 132
++ FM + + + G+ + AGS A A + P ++V+
Sbjct: 102 RIFPYGAIQFMAFEHYKTLITTKLGIS-----GHVHRLMAGSMAGMTAVICTYPLDMVRV 156
Query: 133 RLQTMYEMEMSGK-IAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGY---FFFF 188
RL + E S I + TI++ K+ G GFY GL T+L P FF F
Sbjct: 157 RLAFQVKGEHSYTGIIHAFKTIYA------KEGGFFGFYRGLMPTILGMAPYAGVSFFTF 210
Query: 189 GGYE---LSRSFFASGRSKDELGPVHLM------LSGGVAGICLWLVVFPVDCIKSRIQ- 238
G + LS + GR + V ++ L GGVAG + +P D + R+Q
Sbjct: 211 GTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL 270
Query: 239 --VLSMYGKQAGFIGTLLSVVRNEGI-VALYSGLKATMIRAIPANGALFVAYEYSRK 292
VL + K T+ V + GI LY GL IR IP+ F YE ++
Sbjct: 271 GTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQ 327
Score = 56.6 bits (135), Expect = 3e-08
Identities = 29/85 (34%), Positives = 46/85 (54%)
Query: 214 LSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKATM 273
L+GG+AG C V P+D +K +Q + + K G L +V + EG + LY G A M
Sbjct: 41 LAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMM 100
Query: 274 IRAIPANGALFVAYEYSRKMMMKQL 298
IR P F+A+E+ + ++ +L
Sbjct: 101 IRIFPYGAIQFMAFEHYKTLITTKL 125
Score = 52.0 bits (123), Expect = 6e-07
Identities = 42/184 (22%), Positives = 80/184 (43%), Gaps = 13/184 (7%)
Query: 107 LQTAAAGSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGP 166
L++ AG A A + P + VK LQ H ++S ++ + +K+G
Sbjct: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY-------KHLGVFSALRAVPQKEGF 89
Query: 167 LGFYHGLSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLV 226
LG Y G + +++ P F +E ++ + G VH +++G +AG+ +
Sbjct: 90 LGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGIS--GHVHRLMAGSMAGMTAVIC 147
Query: 227 VFPVDCIKSRIQVLSMYGKQA--GFIGTLLSVVRNE-GIVALYSGLKATMIRAIPANGAL 283
+P+D ++ R+ + G+ + G I ++ E G Y GL T++ P G
Sbjct: 148 TYPLDMVRVRL-AFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVS 206
Query: 284 FVAY 287
F +
Sbjct: 207 FFTF 210
Score = 46.6 bits (109), Expect = 3e-05
Identities = 52/201 (25%), Positives = 77/201 (38%), Gaps = 20/201 (9%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQ---TFPDLYKGLTDCFLKTYAQVG-LRGFYKGTG 68
L AG+ G V+ P D ++V++ Y G+ F YA+ G GFY+G
Sbjct: 134 LMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLM 193
Query: 69 PALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSD------LQTAA---AGSFASAF 119
P ++ V F +G + A SD L+T G A A
Sbjct: 194 PTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAI 253
Query: 120 AALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVV--KGILKKDGPLGFYHGLSSTL 177
A P ++ + R+Q + K +T+ V GI K G Y GLS
Sbjct: 254 AQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRK-----GLYRGLSLNY 308
Query: 178 LQEVPGYFFFFGGYELSRSFF 198
++ +P F YEL + FF
Sbjct: 309 IRCIPSQAVAFTTYELMKQFF 329
Score = 34.7 bits (78), Expect = 0.11
Identities = 24/91 (26%), Positives = 37/91 (40%), Gaps = 6/91 (6%)
Query: 7 IQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQ---TFPDLYKGLT--DCFLKTYAQVGLR 61
++ ++L G G PFD + +MQ P+ K LT D Y G+R
Sbjct: 238 LKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIR 297
Query: 62 -GFYKGTGPALMAYVAENSVLFMCYGFCQQF 91
G Y+G + + +V F Y +QF
Sbjct: 298 KGLYRGLSLNYIRCIPSQAVAFTTYELMKQF 328
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 81.6 bits (200), Expect = 8e-16
Identities = 73/292 (25%), Positives = 126/292 (43%), Gaps = 23/292 (7%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQ----TFPDLYKGLTDCFLKTYAQVGLRGFYKGTG 68
L G AGG +T P + +K ++Q + P Y+G+ DC +T G+ G Y+G
Sbjct: 30 LAGGLAGGIEICITF-PTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLS 88
Query: 69 PALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFAS-AFAALALCPT 127
L + + +V F + F +R D Q +L + G A A A + +CP
Sbjct: 89 SLLYGSIPKAAVRFGMFEFLSNHMR-----DAQGRLDSTRGLLCGLGAGVAEAVVVVCPM 143
Query: 128 ELVKCRL---QTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGY 184
E +K + QT + G + V+ I+++ G G Y GL++T+L++
Sbjct: 144 ETIKVKFIHDQTSPNPKYRG--------FFHGVREIVREQGLKGTYQGLTATVLKQGSNQ 195
Query: 185 FFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYG 244
F R+++ + P+ + G +AG P+D IK+R+Q L +
Sbjct: 196 AIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAH- 254
Query: 245 KQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMK 296
K L +++ EG+ A Y G + R +FV Y+ K++ K
Sbjct: 255 KYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNK 306
Score = 49.3 bits (116), Expect = 4e-06
Identities = 28/81 (34%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 16 GAAGGTACVLTGQPFDTIKVKMQTFP-DLYKGLTDCFLKTYAQVGLRGFYKGTGPALMAY 74
GA G A V P D IK +MQ Y+ DC L+ + GL+ FYKGT P L
Sbjct: 227 GAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRV 286
Query: 75 VAENSVLFMCYGFCQQFVRKV 95
+ +++F+ Y + + KV
Sbjct: 287 CLDVAIVFVIYDEVVKLLNKV 307
Score = 42.0 bits (97), Expect = 7e-04
Identities = 27/93 (29%), Positives = 49/93 (52%), Gaps = 3/93 (3%)
Query: 199 ASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQV--LSMYGKQAGFIGTLLSV 256
ASG++K P +L+GG+AG + FP + +K+++Q+ S + G +
Sbjct: 16 ASGKAK-LTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQT 74
Query: 257 VRNEGIVALYSGLKATMIRAIPANGALFVAYEY 289
VR+ G++ LY GL + + +IP F +E+
Sbjct: 75 VRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEF 107
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 81.3 bits (199), Expect = 1e-15
Identities = 67/298 (22%), Positives = 121/298 (40%), Gaps = 36/298 (12%)
Query: 15 AGAAGGTACVLTGQPFDTIKVKMQTFPDL---------YKGLTDCFLKTYAQVGLRGFYK 65
AG+ G PFD IK++ Q + Y G+ + + G F+K
Sbjct: 21 AGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWK 80
Query: 66 GTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALC 125
G PA + + +V F+ + + V + + D + G A+ A L +
Sbjct: 81 GHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHF---VCGGLAACMATLTVH 137
Query: 126 PTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYF 185
P ++++ R E K +NT+ V + + +GP FY GL+ TL+ P
Sbjct: 138 PVDVLRTRFAAQGE-------PKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAG 190
Query: 186 FFFGGYELSRSFF-----ASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQV- 239
F Y + + A G+ + L +L G AG+ + +P+D K R+QV
Sbjct: 191 LQFSCYSSLKHLYKWAIPAEGKKNENL---QNLLCGSGAGVISKTLTYPLDLFKKRLQVG 247
Query: 240 --------LSMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEY 289
+ G + V++ EG + + GL ++++A + G +F +YE+
Sbjct: 248 GFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
Score = 66.6 bits (161), Expect = 3e-11
Identities = 51/194 (26%), Positives = 80/194 (41%), Gaps = 7/194 (3%)
Query: 10 AIDLTAGAAGGTACVLTGQPFDTIKVKM--QTFPDLYKGLTDCFLKTYAQVGLRGFYKGT 67
++ G LT P D ++ + Q P +Y L Y G + FYKG
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGL 178
Query: 68 GPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPT 127
P L+A + F CY + + + + K +LQ GS A + P
Sbjct: 179 APTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGK-KNENLQNLLCGSGAGVISKTLTYPL 237
Query: 128 ELVKCRLQT---MYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGY 184
+L K RLQ + G++ + + + K +L+K+G LGF+ GLS +LL+
Sbjct: 238 DLFKKRLQVGGFEHARAAFGQVRR-YKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALST 296
Query: 185 FFFFGGYELSRSFF 198
F F YE + F
Sbjct: 297 GFMFFSYEFFCNVF 310
Score = 30.0 bits (66), Expect = 2.6
Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 7/82 (8%)
Query: 214 LSGGVAGICLWLVVFPVDCIKSRIQV----LSMYGKQAGFIGTLLS---VVRNEGIVALY 266
++G V+G+ ++ P D IK R Q+ LS A + G L + +++ EG A +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 267 SGLKATMIRAIPANGALFVAYE 288
G I +I F+++E
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFE 101
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 81.3 bits (199), Expect = 1e-15
Identities = 67/298 (22%), Positives = 121/298 (40%), Gaps = 36/298 (12%)
Query: 15 AGAAGGTACVLTGQPFDTIKVKMQTFPDL---------YKGLTDCFLKTYAQVGLRGFYK 65
AG+ G PFD IK++ Q + Y G+ + + G F+K
Sbjct: 21 AGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWK 80
Query: 66 GTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALC 125
G PA + + +V F+ + + V + + D + G A+ A L +
Sbjct: 81 GHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHF---VCGGLAACMATLTVH 137
Query: 126 PTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYF 185
P ++++ R E K +NT+ V + + +GP FY GL+ TL+ P
Sbjct: 138 PVDVLRTRFAAQGE-------PKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAG 190
Query: 186 FFFGGYELSRSFF-----ASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQV- 239
F Y + + A G+ + L +L G AG+ + +P+D K R+QV
Sbjct: 191 LQFSCYSSLKHLYKWAIPAEGKKNENL---QNLLCGSGAGVISKTLTYPLDLFKKRLQVG 247
Query: 240 --------LSMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEY 289
+ G + V++ EG + + GL ++++A + G +F +YE+
Sbjct: 248 GFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
Score = 66.6 bits (161), Expect = 3e-11
Identities = 51/194 (26%), Positives = 80/194 (41%), Gaps = 7/194 (3%)
Query: 10 AIDLTAGAAGGTACVLTGQPFDTIKVKM--QTFPDLYKGLTDCFLKTYAQVGLRGFYKGT 67
++ G LT P D ++ + Q P +Y L Y G + FYKG
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGL 178
Query: 68 GPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPT 127
P L+A + F CY + + + + K +LQ GS A + P
Sbjct: 179 APTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGK-KNENLQNLLCGSGAGVISKTLTYPL 237
Query: 128 ELVKCRLQT---MYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGY 184
+L K RLQ + G++ + + + K +L+K+G LGF+ GLS +LL+
Sbjct: 238 DLFKKRLQVGGFEHARAAFGQVRR-YKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALST 296
Query: 185 FFFFGGYELSRSFF 198
F F YE + F
Sbjct: 297 GFMFFSYEFFCNVF 310
Score = 30.0 bits (66), Expect = 2.6
Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 7/82 (8%)
Query: 214 LSGGVAGICLWLVVFPVDCIKSRIQV----LSMYGKQAGFIGTLLS---VVRNEGIVALY 266
++G V+G+ ++ P D IK R Q+ LS A + G L + +++ EG A +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 267 SGLKATMIRAIPANGALFVAYE 288
G I +I F+++E
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFE 101
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 81.3 bits (199), Expect = 1e-15
Identities = 67/298 (22%), Positives = 121/298 (40%), Gaps = 36/298 (12%)
Query: 15 AGAAGGTACVLTGQPFDTIKVKMQTFPDL---------YKGLTDCFLKTYAQVGLRGFYK 65
AG+ G PFD IK++ Q + Y G+ + + G F+K
Sbjct: 21 AGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWK 80
Query: 66 GTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALC 125
G PA + + +V F+ + + V + + D + G A+ A L +
Sbjct: 81 GHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHF---VCGGLAACMATLTVH 137
Query: 126 PTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYF 185
P ++++ R E K +NT+ V + + +GP FY GL+ TL+ P
Sbjct: 138 PVDVLRTRFAAQGE-------PKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAG 190
Query: 186 FFFGGYELSRSFF-----ASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQV- 239
F Y + + A G+ + L +L G AG+ + +P+D K R+QV
Sbjct: 191 LQFSCYSSLKHLYKWAIPAEGKKNENL---QNLLCGSGAGVISKTLTYPLDLFKKRLQVG 247
Query: 240 --------LSMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEY 289
+ G + V++ EG + + GL ++++A + G +F +YE+
Sbjct: 248 GFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
Score = 66.6 bits (161), Expect = 3e-11
Identities = 51/194 (26%), Positives = 80/194 (41%), Gaps = 7/194 (3%)
Query: 10 AIDLTAGAAGGTACVLTGQPFDTIKVKM--QTFPDLYKGLTDCFLKTYAQVGLRGFYKGT 67
++ G LT P D ++ + Q P +Y L Y G + FYKG
Sbjct: 119 SVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGL 178
Query: 68 GPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPT 127
P L+A + F CY + + + + K +LQ GS A + P
Sbjct: 179 APTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGK-KNENLQNLLCGSGAGVISKTLTYPL 237
Query: 128 ELVKCRLQT---MYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGY 184
+L K RLQ + G++ + + + K +L+K+G LGF+ GLS +LL+
Sbjct: 238 DLFKKRLQVGGFEHARAAFGQVRR-YKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALST 296
Query: 185 FFFFGGYELSRSFF 198
F F YE + F
Sbjct: 297 GFMFFSYEFFCNVF 310
Score = 30.0 bits (66), Expect = 2.6
Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 7/82 (8%)
Query: 214 LSGGVAGICLWLVVFPVDCIKSRIQV----LSMYGKQAGFIGTLLS---VVRNEGIVALY 266
++G V+G+ ++ P D IK R Q+ LS A + G L + +++ EG A +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 267 SGLKATMIRAIPANGALFVAYE 288
G I +I F+++E
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFE 101
>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
Length = 304
Score = 78.6 bits (192), Expect = 6e-15
Identities = 72/302 (23%), Positives = 126/302 (41%), Gaps = 25/302 (8%)
Query: 7 IQAAIDLTAGAAGGT-ACVLTGQPFDTIKVKMQ---------TFPDLYKGLTDCFLKTYA 56
+ A+DL GA+ ACV T P + +K ++Q T+P Y G
Sbjct: 4 VPPAVDLVLGASACCLACVFTN-PLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVAR 62
Query: 57 QVGLRGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFA 116
GL G KG L+ N V F CY Q AG+ +Q T AG+ A
Sbjct: 63 ADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ-----AGLTQQPG----GTVVAGAVA 113
Query: 117 SAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSST 176
A A P L+K +LQ ++ +H T+ ++ I ++ G LG + G+
Sbjct: 114 GALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGA 173
Query: 177 LLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSR 236
+ + + G + ++++ + E + + G ++ I + +V+ P D + +R
Sbjct: 174 VPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTR 233
Query: 237 I--QVLSMYGK---QAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSR 291
+ Q + G+ G ++ + R EG +ALY GL +R P + ++ R
Sbjct: 234 LYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELR 293
Query: 292 KM 293
K+
Sbjct: 294 KL 295
Score = 52.4 bits (124), Expect = 5e-07
Identities = 46/192 (23%), Positives = 86/192 (44%), Gaps = 13/192 (6%)
Query: 113 GSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHG 172
G+ A A + P E+VK RLQ E++ G + ++ + V + + DG G G
Sbjct: 13 GASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQKG 72
Query: 173 LSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDC 232
L++ LL + F Y L+ +G ++ G V ++G VAG V P
Sbjct: 73 LAAGLLYQGLMNGVRFYCYSLA---CQAGLTQQPGGTV---VAGAVAGALGAFVGSPAYL 126
Query: 233 IKSRIQVLSMYGKQAG-------FIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFV 285
IK+++Q ++ G +G L ++ R +G++ L+ G+ + R + + A
Sbjct: 127 IKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLA 186
Query: 286 AYEYSRKMMMKQ 297
+ ++ + KQ
Sbjct: 187 TFASAKAWVQKQ 198
Score = 47.4 bits (111), Expect = 2e-05
Identities = 30/94 (31%), Positives = 45/94 (47%), Gaps = 11/94 (11%)
Query: 11 IDLTAGAAGGTACVLTGQPFDTIKVKMQTFP-------DLYKGLTDCFLKTYAQVGLRGF 63
+ L G A V+ PFD + ++ P LY GLTDC +K + Q G
Sbjct: 208 VALAGGMISSIAVVVVMTPFDVVSTRLYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLAL 267
Query: 64 YKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAG 97
YKG GPA + + +++L M + +RK+AG
Sbjct: 268 YKGLGPAYLR-LGPHTILSMLF---WDELRKLAG 297
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 78.2 bits (191), Expect = 8e-15
Identities = 79/305 (25%), Positives = 122/305 (40%), Gaps = 41/305 (13%)
Query: 13 LTAGAAG--GTACVLTGQPFDTIKVKMQTFPD---LYKGLTDCFLKTYAQVGLRGFYKGT 67
+ G AG G CV P D K ++Q + +Y ++DC +KT G G Y+G
Sbjct: 13 INGGIAGLIGVTCVF---PIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGA 69
Query: 68 GPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPT 127
L E ++ F R D Q KL+ L+ AG A + P
Sbjct: 70 AVNLTLVTPEKAIKLA----ANDFFRHQLSKDGQ-KLTLLKEMLAGCGAGTCQVIVTTPM 124
Query: 128 ELVKCRLQTMYEMEMSGKI--------------------AKSHNTIWSVVKGILKKDGPL 167
E++K +LQ + KI A T + + +L+ G
Sbjct: 125 EMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIA 184
Query: 168 GFYHGLSSTLLQEVPGYFFFFGGYELSRSFFASGR-SKDELGPVHL-MLSGGVAGICLWL 225
G Y GL +TLL++VP +F L + GR + +E P ++ L+G VAG +
Sbjct: 185 GLYKGLGATLLRDVPFSVVYF---PLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAV 241
Query: 226 VVFPVDCIKSRIQVLSMYGKQ---AGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGA 282
V P D +K+R+Q L + +G + ++R+EG A G + P G
Sbjct: 242 AVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFGI 301
Query: 283 LFVAY 287
V Y
Sbjct: 302 AQVVY 306
Score = 39.7 bits (91), Expect = 0.003
Identities = 23/86 (26%), Positives = 40/86 (46%), Gaps = 3/86 (3%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQ--AGFIGTLLSVVRNEGIVALYSGLK 270
+++GG+AG+ VFP+D K+R+Q G++ L+ VR+EG +Y G
Sbjct: 12 LINGGIAGLIGVTCVFPIDLAKTRLQ-NQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
Query: 271 ATMIRAIPANGALFVAYEYSRKMMMK 296
+ P A ++ R + K
Sbjct: 71 VNLTLVTPEKAIKLAANDFFRHQLSK 96
Score = 35.8 bits (81), Expect = 0.048
Identities = 18/61 (29%), Positives = 26/61 (42%), Gaps = 5/61 (8%)
Query: 11 IDLTAGAAGGTACVLTGQPFDTIKVKMQTF-----PDLYKGLTDCFLKTYAQVGLRGFYK 65
+ AG G+A + P D +K ++Q+ D Y G+ DC K G F K
Sbjct: 227 VSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLK 286
Query: 66 G 66
G
Sbjct: 287 G 287
>gi|149274607 solute carrier family 25, member 41 [Homo sapiens]
Length = 370
Score = 78.2 bits (191), Expect = 8e-15
Identities = 65/287 (22%), Positives = 121/287 (42%), Gaps = 19/287 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTIKVKMQTFPDL--YKGLTDCFLKTYAQVGLRGFYKGTGPA 70
L +GA G P D KV MQ + + L + G R ++G G
Sbjct: 96 LLSGAMAGAVSRTGTAPLDRAKVYMQVYSSKTNFTNLLGGLQSMVQEGGFRSLWRGNGIN 155
Query: 71 LMAYVAENSVLFMCYGFCQQFVRKVAGMDK-QAKLSDLQTAAAGSFASAFAALALCPTEL 129
++ E ++ F + C+ + + G Q +L AGS A A + + P E+
Sbjct: 156 VLKIAPEYAIKFSVFEQCKNYFCGIQGSPPFQERL------LAGSLAVAISQTLINPMEV 209
Query: 130 VKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFG 189
+K RL + G + + IL+++G Y G +L +P
Sbjct: 210 LKTRLTLRRTGQYKGLL--------DCARQILQREGTRALYRGYLPNMLGIIPYACTDLA 261
Query: 190 GYELSRSFFA-SGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVL-SMYGKQA 247
YE+ + F+ SGR + + + S ++ C + +P+ +++R+Q ++ G
Sbjct: 262 VYEMLQCFWVKSGRDMGDPSGLVSLSSVTLSTTCGQMASYPLTLVRTRMQAQDTVEGSNP 321
Query: 248 GFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMM 294
G L ++ +G + LY G+ T+++ +PA G +V YE +K +
Sbjct: 322 TMRGVLQRILAQQGWLGLYRGMTPTLLKVLPAGGISYVVYEAMKKTL 368
>gi|13899342 solute carrier [Homo sapiens]
Length = 315
Score = 77.0 bits (188), Expect = 2e-14
Identities = 69/250 (27%), Positives = 107/250 (42%), Gaps = 32/250 (12%)
Query: 13 LTAGAAG--GTACVLTGQPFDTIKVKMQTFPD--LYKGLTDCFLKTYAQVGLRGFYKGTG 68
+ G AG G CV P D K ++Q +YKG+ DC +KT G G Y+G
Sbjct: 13 INGGVAGLVGVTCVF---PIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEGFFGMYRGAA 69
Query: 69 PALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTE 128
L E ++ F ++ + + GM + K+ L AG A + CP E
Sbjct: 70 VNLTLVTPEKAIKLAANDFFRRLLME-DGMQRNLKMEML----AGCGAGMCQVVVTCPME 124
Query: 129 LVKCRLQTMYEMEMSGK-IAKSHNTIWSVVKG----------------ILKKDGPLGFYH 171
++K +LQ + + + A + +T S G +L+ G G Y
Sbjct: 125 MLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYR 184
Query: 172 GLSSTLLQEVPGYFFFFGGY-ELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPV 230
GL +TLL+++P +F + L+ F K H +SG VAG + V P+
Sbjct: 185 GLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASF--AHSFVSGCVAGSIAAVAVTPL 242
Query: 231 DCIKSRIQVL 240
D +K+RIQ L
Sbjct: 243 DVLKTRIQTL 252
Score = 48.1 bits (113), Expect = 9e-06
Identities = 24/84 (28%), Positives = 40/84 (47%)
Query: 213 MLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKAT 272
+++GGVAG+ VFP+D K+R+Q G I L+ R EG +Y G
Sbjct: 12 LINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEGFFGMYRGAAVN 71
Query: 273 MIRAIPANGALFVAYEYSRKMMMK 296
+ P A ++ R+++M+
Sbjct: 72 LTLVTPEKAIKLAANDFFRRLLME 95
Score = 42.4 bits (98), Expect = 5e-04
Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 5/64 (7%)
Query: 10 AIDLTAGAAGGTACVLTGQPFDTIKVKMQTFP-----DLYKGLTDCFLKTYAQVGLRGFY 64
A +G G+ + P D +K ++QT D+Y G+TDC K + Q G F
Sbjct: 222 AHSFVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFM 281
Query: 65 KGTG 68
KG G
Sbjct: 282 KGAG 285
Score = 35.4 bits (80), Expect = 0.062
Identities = 41/190 (21%), Positives = 73/190 (38%), Gaps = 33/190 (17%)
Query: 113 GSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHG 172
G A + P +L K RLQ + M + + + + +G G Y G
Sbjct: 15 GGVAGLVGVTCVFPIDLAKTRLQNQHGKAM-------YKGMIDCLMKTARAEGFFGMYRG 67
Query: 173 LSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDC 232
+ L P + R + L ML+G AG+C +V P++
Sbjct: 68 AAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKME--MLAGCGAGMCQVVVTCPMEM 125
Query: 233 IKSRIQV---LSMYGKQAGFI-------------------GTLLS--VVRNEGIVALYSG 268
+K ++Q L+++ + + TL++ ++R +G+ LY G
Sbjct: 126 LKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYRG 185
Query: 269 LKATMIRAIP 278
L AT++R IP
Sbjct: 186 LGATLLRDIP 195
>gi|4505775 solute carrier family 25 member 3 isoform b precursor
[Homo sapiens]
Length = 361
Score = 76.3 bits (186), Expect = 3e-14
Identities = 69/269 (25%), Positives = 112/269 (41%), Gaps = 27/269 (10%)
Query: 16 GAAGGTACVLTGQ---PFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGTGPALM 72
G G +C LT P D +K +MQ P YKG+ + F T + G+RG KG P +
Sbjct: 68 GFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFSVTLKEDGVRGLAKGWAPTFL 127
Query: 73 AYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELVKC 132
Y + F Y + + G + AA + A FA +AL P E K
Sbjct: 128 GYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIALAPMEAAKV 187
Query: 133 RLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGGYE 192
R+QT NT+ + K++G FY G++ ++++P F +E
Sbjct: 188 RIQTQ---------PGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFE 238
Query: 193 LSRSF---FASGRSKDELGP----VHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGK 245
+ F + + E V ++G +AG+ +V P D V+S+ K
Sbjct: 239 RTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPAD------SVVSVLNK 292
Query: 246 QAGFIGTLLSVVRNEGIVALYSGLKATMI 274
+ G +L V++ G ++ GL A +I
Sbjct: 293 EKGSSASL--VLKRLGFKGVWKGLFARII 319
Score = 48.9 bits (115), Expect = 5e-06
Identities = 44/182 (24%), Positives = 70/182 (38%), Gaps = 6/182 (3%)
Query: 8 QAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGT 67
+ ++ L A A+ + P + KV++QT P L D K Y + GL+ FYKG
Sbjct: 160 RTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGV 219
Query: 68 GPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSD----LQTAAAGSFASAFAALA 123
P M + + F C+ + + K +++ S + T AG A F A+
Sbjct: 220 APLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIV 279
Query: 124 LCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPG 183
P + V L E S + V KG+ + +G L + V
Sbjct: 280 SHPADSVVSVLNK--EKGSSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDSVKV 337
Query: 184 YF 185
YF
Sbjct: 338 YF 339
Score = 46.2 bits (108), Expect = 4e-05
Identities = 47/191 (24%), Positives = 76/191 (39%), Gaps = 22/191 (11%)
Query: 113 GSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHG 172
G + A+ P +LVKCR+Q + + I++ LK+DG G G
Sbjct: 71 GVLSCGLTHTAVVPLDLVKCRMQVD---------PQKYKGIFNGFSVTLKEDGVRGLAKG 121
Query: 173 LSSTLLQEVPGYFFFFGGYELSRSFFAS--GRSKDELGPVHLMLSGGV-AGICLWLVVFP 229
+ T L FG YE+ + +++ G L L L+ A + + P
Sbjct: 122 WAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWRTSLYLAASASAEFFADIALAP 181
Query: 230 VDCIKSRIQVLSMYGKQAGFIGTLLSVV----RNEGIVALYSGLKATMIRAIPANGALFV 285
++ K RIQ Q G+ TL + EG+ A Y G+ +R IP F
Sbjct: 182 MEAAKVRIQT------QPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFA 235
Query: 286 AYEYSRKMMMK 296
+E + + + K
Sbjct: 236 CFERTVEALYK 246
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,403,803
Number of Sequences: 37866
Number of extensions: 412383
Number of successful extensions: 1532
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 955
Number of HSP's gapped (non-prelim): 205
length of query: 301
length of database: 18,247,518
effective HSP length: 102
effective length of query: 199
effective length of database: 14,385,186
effective search space: 2862652014
effective search space used: 2862652014
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.