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Search of human proteins with 7657585
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
(301 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens] 603 e-173
gi|13994341 solute carrier family 25 member 2 [Homo sapiens] 535 e-152
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 149 3e-36
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 133 2e-31
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 129 4e-30
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 119 4e-27
gi|116235466 solute carrier family 25, member 45 isoform b [Homo... 101 9e-22
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 100 2e-21
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 100 2e-21
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 96 5e-20
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 96 5e-20
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 94 2e-19
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 92 7e-19
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 89 6e-18
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 89 6e-18
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 89 6e-18
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 88 1e-17
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 84 2e-16
gi|46409330 solute carrier family 25, member 34 [Homo sapiens] 81 1e-15
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 81 1e-15
gi|239755176 PREDICTED: similar to solute carrier family 25, mem... 79 6e-15
gi|239755174 PREDICTED: similar to solute carrier family 25, mem... 79 6e-15
gi|56699407 solute carrier family 25, member 25 isoform c [Homo ... 79 6e-15
gi|56699401 solute carrier family 25, member 25 isoform a [Homo ... 79 6e-15
gi|56699405 solute carrier family 25, member 25 isoform d [Homo ... 79 6e-15
gi|56699403 solute carrier family 25, member 25 isoform b [Homo ... 79 6e-15
gi|60460887 solute carrier family 25, member 42 [Homo sapiens] 78 8e-15
gi|82775373 solute carrier family 25, member 37 [Homo sapiens] 77 2e-14
gi|115430257 solute carrier family 25, member 26 [Homo sapiens] 77 2e-14
gi|13899342 solute carrier [Homo sapiens] 77 2e-14
>gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
Length = 301
Score = 603 bits (1555), Expect = e-173
Identities = 301/301 (100%), Positives = 301/301 (100%)
Query: 1 MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGF 60
MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGF
Sbjct: 1 MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGF 60
Query: 61 RGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFA 120
RGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFA
Sbjct: 61 RGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFA 120
Query: 121 ALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLRE 180
ALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLRE
Sbjct: 121 ALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLRE 180
Query: 181 VPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVL 240
VPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVL
Sbjct: 181 VPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVL 240
Query: 241 SMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEA 300
SMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEA
Sbjct: 241 SMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEA 300
Query: 301 Y 301
Y
Sbjct: 301 Y 301
>gi|13994341 solute carrier family 25 member 2 [Homo sapiens]
Length = 301
Score = 535 bits (1379), Expect = e-152
Identities = 263/301 (87%), Positives = 279/301 (92%)
Query: 1 MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGF 60
MKS P IQAAIDLTAGAAGGTACVLTGQPFDT+KVKMQTFPDLY+GLTDC LKTY+QVG
Sbjct: 1 MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGL 60
Query: 61 RGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFA 120
RGFYKGT PAL+A +AENSVLFMCYGFCQQ VRKVAG+DKQAKLSDLQ AAAGSFASAFA
Sbjct: 61 RGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFA 120
Query: 121 ALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLRE 180
AL LCPTELVKCRLQTMYEME SGKIAKS NT+WSV+K IL+KDGPLGFYHGLSSTLL+E
Sbjct: 121 ALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQE 180
Query: 181 VPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVL 240
VPGYFFFFGGYELSRSFFASGRSKDELGPV LMLSGGV GICLWL V+PVDCIKSRIQVL
Sbjct: 181 VPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVL 240
Query: 241 SMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEA 300
SM GKQAGFI T ++VV+NEGI ALYSGLK TMIRA PANGALF+AYEYSRK+MM QLEA
Sbjct: 241 SMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEA 300
Query: 301 Y 301
Y
Sbjct: 301 Y 301
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 149 bits (376), Expect = 3e-36
Identities = 95/291 (32%), Positives = 143/291 (49%), Gaps = 17/291 (5%)
Query: 12 DLTAGAAGGTACVLTGQPFDTMKVKMQTFPD-------LYRGLTDCCLKTYSQVGFRGFY 64
+L AG GG V G P DT+KV++QT P +Y G DC KT + G G Y
Sbjct: 13 NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
Query: 65 KGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVL 124
+G + +I +V F +G +++ +K + LS Q AAG + F ++
Sbjct: 73 RGMAAPIIGVTPMFAVCFFGFGLGKKLQQK----HPEDVLSYPQLFAAGMLSGVFTTGIM 128
Query: 125 CPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGY 184
P E +KC LQ ++ S +K T+ K + ++ G G Y G TL+R+VP
Sbjct: 129 TPGERIKCLLQ----IQASSGESKYTGTL-DCAKKLYQEFGIRGIYKGTVLTLMRDVPAS 183
Query: 185 FFFFGGYELSRSFFA-SGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMS 243
+F YE ++ F G+ EL ++++GG+ GI W P D +KSR Q
Sbjct: 184 GMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPG 243
Query: 244 GKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLM 294
GF ++++EG+T+LY G MIRAFPAN A FL +E + K +
Sbjct: 244 KYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFL 294
Score = 66.6 bits (161), Expect = 3e-11
Identities = 51/197 (25%), Positives = 88/197 (44%), Gaps = 5/197 (2%)
Query: 99 DKQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIK 158
D+ +S L+N AG F V P + VK RLQT G+ T + +
Sbjct: 3 DQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQ-PPSLPGQPPMYSGT-FDCFR 60
Query: 159 SILRKDGPLGFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGV 218
L ++G G Y G+++ ++ P + F G+ L + +D L L +G +
Sbjct: 61 KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKK-LQQKHPEDVLSYPQLFAAGML 119
Query: 219 GGICLWLAVYPVDCIKSRIQVLSMSG--KQAGFIRTFINVVKNEGITALYSGLKPTMIRA 276
G+ + P + IK +Q+ + SG K G + + + GI +Y G T++R
Sbjct: 120 SGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRD 179
Query: 277 FPANGALFLAYEYSRKL 293
PA+G F+ YE+ + +
Sbjct: 180 VPASGMYFMTYEWLKNI 196
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 5/98 (5%)
Query: 207 LGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVL--SMSGK---QAGFIRTFINVVKNEG 261
+ P+ +L+GG GG+CL +P+D +K R+Q S+ G+ +G F + EG
Sbjct: 8 ISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREG 67
Query: 262 ITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLE 299
IT LY G+ +I P F + +KL E
Sbjct: 68 ITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPE 105
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 133 bits (335), Expect = 2e-31
Identities = 88/282 (31%), Positives = 136/282 (48%), Gaps = 8/282 (2%)
Query: 12 DLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPAL 71
+ AG G ++ G PFDT+KV++QT YRG+ DC +K Y GF+KG S +
Sbjct: 5 EFVAGWISGALGLVLGHPFDTVKVRLQT-QTTYRGIVDCMVKIYRHESLLGFFKGMSFPI 63
Query: 72 IANIAENSVLFMCYGFCQQVVRKVAGLDKQAK-LSDLQNAAAGSFASAFAALVLCPTELV 130
+ NSVLF Y V+ + +++A+ S + AG A L P +L+
Sbjct: 64 ASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLI 123
Query: 131 KCRLQTMYEMETS-GKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFG 189
K RLQ E G SI R++GP G + G + LR+ P +F
Sbjct: 124 KVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFI 183
Query: 190 GYE-LSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGK-QA 247
YE L R + G++ ++++GG GI W+A P+D IKSR+Q+ + +
Sbjct: 184 TYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQ 240
Query: 248 GFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEY 289
G + ++ ++ EG+ + G+ RAFP N FL+YEY
Sbjct: 241 GMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
Score = 38.5 bits (88), Expect = 0.007
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 5/87 (5%)
Query: 4 NPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQ---TFPDLYRGLTDCCLKTYSQVGF 60
NP+ +A L AG G A + P D +K +MQ +Y+G+ DC + + Q G
Sbjct: 198 NPS--SATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGL 255
Query: 61 RGFYKGTSPALIANIAENSVLFMCYGF 87
F++G + N+V F+ Y +
Sbjct: 256 GVFFRGVTINSARAFPVNAVTFLSYEY 282
Score = 28.9 bits (63), Expect = 5.8
Identities = 16/79 (20%), Positives = 33/79 (41%), Gaps = 3/79 (3%)
Query: 209 PVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSG 268
PV ++G + G + +P D +K R+Q + G + + + ++E + + G
Sbjct: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQT---TYRGIVDCMVKIYRHESLLGFFKG 58
Query: 269 LKPTMIRAFPANGALFLAY 287
+ + N LF Y
Sbjct: 59 MSFPIASIAVVNSVLFGVY 77
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 129 bits (323), Expect = 4e-30
Identities = 96/281 (34%), Positives = 133/281 (47%), Gaps = 22/281 (7%)
Query: 10 AIDLTAGAAGGTACVLTGQPFDTMKVKMQTFP---DLYRGLTDCCLKTYSQVGFRGFYKG 66
A+D AG AGG A VL G PFDT+KV++Q YRG C Q G YKG
Sbjct: 2 ALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKG 61
Query: 67 TSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCP 126
L+ N+++F G + + G D S L AG+ A A ++ CP
Sbjct: 62 LGSPLMGLTFINALVFGVQGNTLRAL----GHD-----SPLNQFLAGAAAGAIQCVICCP 112
Query: 127 TELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFF 186
EL K RLQ ++ +G A++ + I +G G G+ STLLRE P +
Sbjct: 113 MELAKTRLQ----LQDAGP-ARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGV 167
Query: 187 FFGGYE-LSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSG- 244
+F Y+ L+R+ D L L+L+GG GI WL+ YPVD +KSR+Q + G
Sbjct: 168 YFLTYDALTRALGCE--PGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGA 225
Query: 245 -KQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALF 284
+ G + + EG GL T++RAFP N A F
Sbjct: 226 PRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATF 266
Score = 48.5 bits (114), Expect = 7e-06
Identities = 47/183 (25%), Positives = 75/183 (40%), Gaps = 22/183 (12%)
Query: 112 AGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQ-NTVWSVIKSILRKDGPLGFY 170
AG LV P + VK RLQ + K Q KSI++++ LG Y
Sbjct: 7 AGCAGGVAGVLVGHPFDTVKVRLQVQ-------SVEKPQYRGTLHCFKSIIKQESVLGLY 59
Query: 171 HGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELG---PVPLMLSGGVGGICLWLAV 227
GL S L+ G F + F G + LG P+ L+G G +
Sbjct: 60 KGLGSPLM----GLTFIN-----ALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVIC 110
Query: 228 YPVDCIKSRIQVLSMSGKQA--GFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFL 285
P++ K+R+Q+ + G + + +EG+ + G+ T++R P+ G FL
Sbjct: 111 CPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFL 170
Query: 286 AYE 288
Y+
Sbjct: 171 TYD 173
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 119 bits (297), Expect = 4e-27
Identities = 85/300 (28%), Positives = 137/300 (45%), Gaps = 25/300 (8%)
Query: 11 IDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPA 70
+D AGA GG V G P DT+KV++QT P Y G+ C TY + GFY+G S
Sbjct: 1 MDFVAGAIGGVCGVAVGYPLDTVKVRIQTEPK-YTGIWHCVRDTYHRERVWGFYRGLSLP 59
Query: 71 LIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELV 130
+ +SV F Y C + ++ + AK + +G + + PTE+
Sbjct: 60 VCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTEVA 119
Query: 131 KCRLQTMYE-------METSGKIA-------------KSQNTVWSVIKSILRKDGPLGFY 170
K RLQT + + SG +A + ++ R++G G Y
Sbjct: 120 KVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLY 179
Query: 171 HGLSSTLLREVPGYFFFFGGYELSRSFFA-SGRSKDELGPVPLMLSGGVGGICLWLAVYP 229
G S+ +LR+ + +F Y + + + +G S+ ++ V +++GG G+ W P
Sbjct: 180 KGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGV--LVAGGCAGVLAWAVATP 237
Query: 230 VDCIKSRIQVLSMSGKQ-AGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
+D IKSR+Q ++ G + + V+ EG L+ GL RAFP N +F+AYE
Sbjct: 238 MDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYE 297
>gi|116235466 solute carrier family 25, member 45 isoform b [Homo
sapiens]
Length = 246
Score = 101 bits (251), Expect = 9e-22
Identities = 70/242 (28%), Positives = 111/242 (45%), Gaps = 7/242 (2%)
Query: 52 LKTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNA- 110
+K Y GF+KG S + + NSVLF Y V+ + +++A+ +
Sbjct: 2 VKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIF 61
Query: 111 AAGSFASAFAALVLCPTELVKCRLQTMYEMETS-GKIAKSQNTVWSVIKSILRKDGPLGF 169
AG A L P +L+K RLQ E G SI R++GP G
Sbjct: 62 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 121
Query: 170 YHGLSSTLLREVPGYFFFFGGYE-LSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVY 228
+ G + LR+ P +F YE L R + G++ ++++GG GI W+A
Sbjct: 122 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAAT 178
Query: 229 PVDCIKSRIQVLSMSGK-QAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAY 287
P+D IKSR+Q+ + + G + ++ ++ EG+ + G+ RAFP N FL+Y
Sbjct: 179 PLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSY 238
Query: 288 EY 289
EY
Sbjct: 239 EY 240
Score = 47.4 bits (111), Expect = 2e-05
Identities = 43/189 (22%), Positives = 72/189 (38%), Gaps = 23/189 (12%)
Query: 15 AGAAGGTACVLTGQPFDTMKVKMQTF----------PDLYRGLTDCCLKTYSQVGFRGFY 64
AG GG PFD +KV++Q P Y+G C + + G RG +
Sbjct: 63 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 122
Query: 65 KGTSPALIANIAENSVLFMCY-GFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALV 123
+G + + + F+ Y G C+Q + L AG FA + +
Sbjct: 123 RGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVL------VAGGFAGIASWVA 176
Query: 124 LCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPG 183
P +++K R M+ G + + + S +R++G F+ G++ R P
Sbjct: 177 ATPLDMIKSR------MQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPV 230
Query: 184 YFFFFGGYE 192
F YE
Sbjct: 231 NAVTFLSYE 239
Score = 38.5 bits (88), Expect = 0.007
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 5/87 (5%)
Query: 4 NPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFP---DLYRGLTDCCLKTYSQVGF 60
NP+ +A L AG G A + P D +K +MQ +Y+G+ DC + + Q G
Sbjct: 156 NPS--SATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGL 213
Query: 61 RGFYKGTSPALIANIAENSVLFMCYGF 87
F++G + N+V F+ Y +
Sbjct: 214 GVFFRGVTINSARAFPVNAVTFLSYEY 240
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 100 bits (248), Expect = 2e-21
Identities = 79/293 (26%), Positives = 125/293 (42%), Gaps = 30/293 (10%)
Query: 6 AIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPD--------LYRGLTDCCLKTYSQ 57
A + + AGA G TA P D +K +MQ +Y+ DC K
Sbjct: 329 AYRFGLGSVAGAVGATAVY----PIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRY 384
Query: 58 VGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFAS 117
GF G Y+G P L+ E ++ F + + K + AG A
Sbjct: 385 EGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKF-----MHKDGSVPLAAEILAGGCAG 439
Query: 118 AFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTL 177
+ P E+VK RLQ E+ T +++ S++R G G Y G +
Sbjct: 440 GSQVIFTNPLEIVKIRLQVAGEITTGPRVSAL---------SVVRDLGFFGIYKGAKACF 490
Query: 178 LREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRI 237
LR++P +F Y ++ FA+ ++ P L+L+G + G+ V P D IK+R+
Sbjct: 491 LRDIPFSAIYFPCYAHVKASFAN--EDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRL 548
Query: 238 QVLSMSGK--QAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
QV + +G+ +G I F +++ EG AL+ G + R+ P G L YE
Sbjct: 549 QVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 601
Score = 71.2 bits (173), Expect = 1e-12
Identities = 48/202 (23%), Positives = 92/202 (45%), Gaps = 18/202 (8%)
Query: 1 MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGF 60
M + ++ A ++ AG G + V+ P + +K+++Q ++ G L +GF
Sbjct: 420 MHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGF 479
Query: 61 RGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFA 120
G YKG + +I +++ F CY K + ++ ++S AG+ A A
Sbjct: 480 FGIYKGAKACFLRDIPFSAIYFPCYAHV-----KASFANEDGQVSPGSLLLAGAIAGMPA 534
Query: 121 ALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVI----KSILRKDGPLGFYHGLSST 176
A ++ P +++K RLQ A++ T +S + + ILR++GP + G +
Sbjct: 535 ASLVTPADVIKTRLQV---------AARAGQTTYSGVIDCFRKILREEGPKALWKGAGAR 585
Query: 177 LLREVPGYFFFFGGYELSRSFF 198
+ R P + YEL + +F
Sbjct: 586 VFRSSPQFGVTLLTYELLQRWF 607
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 6/88 (6%)
Query: 216 GGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIR------TFINVVKNEGITALYSGL 269
G V G AVYP+D +K+R+Q +G G + F V++ EG LY GL
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 394
Query: 270 KPTMIRAFPANGALFLAYEYSRKLMMNQ 297
P ++ P ++ R M++
Sbjct: 395 LPQLLGVAPEKAIKLTVNDFVRDKFMHK 422
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 100 bits (248), Expect = 2e-21
Identities = 79/293 (26%), Positives = 125/293 (42%), Gaps = 30/293 (10%)
Query: 6 AIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPD--------LYRGLTDCCLKTYSQ 57
A + + AGA G TA P D +K +MQ +Y+ DC K
Sbjct: 330 AYRFGLGSVAGAVGATAVY----PIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRY 385
Query: 58 VGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFAS 117
GF G Y+G P L+ E ++ F + + K + AG A
Sbjct: 386 EGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKF-----MHKDGSVPLAAEILAGGCAG 440
Query: 118 AFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTL 177
+ P E+VK RLQ E+ T +++ S++R G G Y G +
Sbjct: 441 GSQVIFTNPLEIVKIRLQVAGEITTGPRVSAL---------SVVRDLGFFGIYKGAKACF 491
Query: 178 LREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRI 237
LR++P +F Y ++ FA+ ++ P L+L+G + G+ V P D IK+R+
Sbjct: 492 LRDIPFSAIYFPCYAHVKASFAN--EDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRL 549
Query: 238 QVLSMSGK--QAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
QV + +G+ +G I F +++ EG AL+ G + R+ P G L YE
Sbjct: 550 QVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 602
Score = 71.2 bits (173), Expect = 1e-12
Identities = 48/202 (23%), Positives = 92/202 (45%), Gaps = 18/202 (8%)
Query: 1 MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGF 60
M + ++ A ++ AG G + V+ P + +K+++Q ++ G L +GF
Sbjct: 421 MHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGF 480
Query: 61 RGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFA 120
G YKG + +I +++ F CY K + ++ ++S AG+ A A
Sbjct: 481 FGIYKGAKACFLRDIPFSAIYFPCYAHV-----KASFANEDGQVSPGSLLLAGAIAGMPA 535
Query: 121 ALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVI----KSILRKDGPLGFYHGLSST 176
A ++ P +++K RLQ A++ T +S + + ILR++GP + G +
Sbjct: 536 ASLVTPADVIKTRLQV---------AARAGQTTYSGVIDCFRKILREEGPKALWKGAGAR 586
Query: 177 LLREVPGYFFFFGGYELSRSFF 198
+ R P + YEL + +F
Sbjct: 587 VFRSSPQFGVTLLTYELLQRWF 608
Score = 40.4 bits (93), Expect = 0.002
Identities = 34/120 (28%), Positives = 50/120 (41%), Gaps = 17/120 (14%)
Query: 192 ELSRSFFASGRSKDELGPVPLMLS--------GGVGGICLWLAVYPVDCIKSRIQVLSMS 243
E R ASG D PV L ++ G V G AVYP+D +K+R+Q +
Sbjct: 307 EAQRQQKASG---DSARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRST 363
Query: 244 GKQAGFIR------TFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQ 297
G G + F V++ EG LY GL P ++ P ++ R M++
Sbjct: 364 GSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHK 423
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 95.5 bits (236), Expect = 5e-20
Identities = 72/292 (24%), Positives = 127/292 (43%), Gaps = 27/292 (9%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFP------DLYRGLTDCCLKTYSQVGFRGFYKG 66
L AG G + P D +K+ MQ +++ G + + G R ++G
Sbjct: 198 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFR----QMVKEGGIRSLWRG 253
Query: 67 TSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCP 126
+I E +V F Y ++++ ++ K+ + +GS A A A + P
Sbjct: 254 NGTNVIKIAPETAVKFWAYEQYKKLLT-----EEGQKIGTFERFISGSMAGATAQTFIYP 308
Query: 127 TELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFF 186
E++K RL + SG ++ K IL+ +G FY G LL +P
Sbjct: 309 MEVMKTRLAVGKTGQYSG--------IYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGI 360
Query: 187 FFGGYELSRSFFASGRSKDELGPVPLML--SGGVGGICLWLAVYPVDCIKSRIQVLSM-- 242
YEL +S++ +KD + P ++L G + C LA YP+ +++R+Q +M
Sbjct: 361 DLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLE 420
Query: 243 SGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLM 294
Q + F ++ EGI LY G+ P ++ PA G ++ YE ++ +
Sbjct: 421 GSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 472
Score = 43.1 bits (100), Expect = 3e-04
Identities = 24/85 (28%), Positives = 40/85 (47%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+L+GG+ G + P+D +K +QV + F +VK GI +L+ G
Sbjct: 198 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTN 257
Query: 273 MIRAFPANGALFLAYEYSRKLMMNQ 297
+I+ P F AYE +KL+ +
Sbjct: 258 VIKIAPETAVKFWAYEQYKKLLTEE 282
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 95.5 bits (236), Expect = 5e-20
Identities = 72/292 (24%), Positives = 127/292 (43%), Gaps = 27/292 (9%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFP------DLYRGLTDCCLKTYSQVGFRGFYKG 66
L AG G + P D +K+ MQ +++ G + + G R ++G
Sbjct: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFR----QMVKEGGIRSLWRG 234
Query: 67 TSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCP 126
+I E +V F Y ++++ ++ K+ + +GS A A A + P
Sbjct: 235 NGTNVIKIAPETAVKFWAYEQYKKLLT-----EEGQKIGTFERFISGSMAGATAQTFIYP 289
Query: 127 TELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFF 186
E++K RL + SG ++ K IL+ +G FY G LL +P
Sbjct: 290 MEVMKTRLAVGKTGQYSG--------IYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGI 341
Query: 187 FFGGYELSRSFFASGRSKDELGPVPLML--SGGVGGICLWLAVYPVDCIKSRIQVLSM-- 242
YEL +S++ +KD + P ++L G + C LA YP+ +++R+Q +M
Sbjct: 342 DLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLE 401
Query: 243 SGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLM 294
Q + F ++ EGI LY G+ P ++ PA G ++ YE ++ +
Sbjct: 402 GSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTL 453
Score = 43.1 bits (100), Expect = 3e-04
Identities = 24/85 (28%), Positives = 40/85 (47%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+L+GG+ G + P+D +K +QV + F +VK GI +L+ G
Sbjct: 179 LLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTN 238
Query: 273 MIRAFPANGALFLAYEYSRKLMMNQ 297
+I+ P F AYE +KL+ +
Sbjct: 239 VIKIAPETAVKFWAYEQYKKLLTEE 263
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 93.6 bits (231), Expect = 2e-19
Identities = 75/291 (25%), Positives = 119/291 (40%), Gaps = 26/291 (8%)
Query: 8 QAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPD--------LYRGLTDCCLKTYSQVG 59
++A T G+ G P D +K +MQ +Y+ DC K G
Sbjct: 325 ESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEG 384
Query: 60 FRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAF 119
F G Y+G P LI E ++ F + K D L AG A
Sbjct: 385 FFGLYRGLIPQLIGVAPEKAIKLTVNDFVRD---KFTRRDGSVPLP--AEVLAGGCAGGS 439
Query: 120 AALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLR 179
+ P E+VK RLQ E+ T +++ ++LR G G Y G + LR
Sbjct: 440 QVIFTNPLEIVKIRLQVAGEITTGPRVS---------ALNVLRDLGIFGLYKGAKACFLR 490
Query: 180 EVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQV 239
++P +F Y + A +G + L+ +G + G+ V P D IK+R+QV
Sbjct: 491 DIPFSAIYFPVYAHCKLLLAD--ENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQV 548
Query: 240 LSMSGK--QAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
+ +G+ +G I F +++ EG +A + G + R+ P G + YE
Sbjct: 549 AARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYE 599
Score = 74.7 bits (182), Expect = 9e-14
Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 19/190 (10%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPALI 72
L G AGG+ + T P + +K+++Q ++ G L +G G YKG +
Sbjct: 431 LAGGCAGGSQVIFTN-PLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFL 489
Query: 73 ANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELVKC 132
+I +++ F Y C K+ D+ + L AAG+ A AA ++ P +++K
Sbjct: 490 RDIPFSAIYFPVYAHC-----KLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKT 544
Query: 133 RLQTMYEMETSGKIAKSQNTVWSVI----KSILRKDGPLGFYHGLSSTLLREVPGYFFFF 188
RLQ A++ T +S + + ILR++GP F+ G ++ + R P +
Sbjct: 545 RLQV---------AARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTL 595
Query: 189 GGYELSRSFF 198
YEL + +F
Sbjct: 596 VTYELLQRWF 605
Score = 62.0 bits (149), Expect = 6e-10
Identities = 64/239 (26%), Positives = 103/239 (43%), Gaps = 31/239 (12%)
Query: 72 IANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNA---AAGSFASAFAALVLCPTE 128
IA +AE + + Y + ++ GL + L ++A GS A A A + P +
Sbjct: 292 IAPLAEGA---LPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPID 348
Query: 129 LVKCRLQTMYEMETSGKIAKS--QNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFF 186
LVK R+Q SG + + K +LR +G G Y GL L+ P
Sbjct: 349 LVKTRMQNQ---RGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEK-- 403
Query: 187 FFGGYELSRSFFASGRSKDELGPVPL---MLSGGVGGICLWLAVYPVDCIKSRIQVLSMS 243
+L+ + F + G VPL +L+GG G + P++ +K R+QV
Sbjct: 404 ---AIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQV---- 456
Query: 244 GKQAGFIRT-----FINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQ 297
AG I T +NV+++ GI LY G K +R P + F Y + + L+ ++
Sbjct: 457 ---AGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADE 512
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 91.7 bits (226), Expect = 7e-19
Identities = 72/292 (24%), Positives = 126/292 (43%), Gaps = 27/292 (9%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFP------DLYRGLTDCCLKTYSQVGFRGFYKG 66
L AGA G P D +KV MQ ++ GL L+ G R ++G
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEG----GIRSLWRG 244
Query: 67 TSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCP 126
++ E+++ FM Y +Q+ R + G +Q L + AGS A A A ++ P
Sbjct: 245 NGINVLKIAPESAIKFMAY---EQIKRAILG--QQETLHVQERFVAGSLAGATAQTIIYP 299
Query: 127 TELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFF 186
E++K RL + G + + IL ++GP FY G +L +P
Sbjct: 300 MEVLKTRLTLRRTGQYKGLL--------DCARRILEREGPRAFYRGYLPNVLGIIPYAGI 351
Query: 187 FFGGYELSRSFFASGRSKDELGP--VPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSM-- 242
YE ++++ S D P + L+ G + C +A YP+ +++R+Q +
Sbjct: 352 DLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIE 411
Query: 243 SGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLM 294
G Q + +++ EG+ LY G+ P ++ PA ++ YE ++ +
Sbjct: 412 GGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQAL 463
Score = 44.7 bits (104), Expect = 1e-04
Identities = 42/201 (20%), Positives = 87/201 (43%), Gaps = 14/201 (6%)
Query: 100 KQAKLSDL--QNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVI 157
KQ KL+ + + AG+ A A + P + +K +Q ++ +T+ + + +
Sbjct: 177 KQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQ-VHASKTN------RLNILGGL 229
Query: 158 KSILRKDGPLGFYHGLSSTLLREVPGYFFFFGGYE-LSRSFFASGRSKDELGPVPLMLSG 216
+S++ + G + G +L+ P F YE + R+ ++ L ++G
Sbjct: 230 RSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQ---QETLHVQERFVAG 286
Query: 217 GVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRA 276
+ G +YP++ +K+R+ L +G+ G + +++ EG A Y G P ++
Sbjct: 287 SLAGATAQTIIYPMEVLKTRL-TLRRTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGI 345
Query: 277 FPANGALFLAYEYSRKLMMNQ 297
P G YE + + Q
Sbjct: 346 IPYAGIDLAVYETLKNWWLQQ 366
Score = 35.0 bits (79), Expect = 0.081
Identities = 20/87 (22%), Positives = 42/87 (48%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+++G V G P+D +K +QV + + + ++V GI +L+ G
Sbjct: 189 LVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNGIN 248
Query: 273 MIRAFPANGALFLAYEYSRKLMMNQLE 299
+++ P + F+AYE ++ ++ Q E
Sbjct: 249 VLKIAPESAIKFMAYEQIKRAILGQQE 275
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 88.6 bits (218), Expect = 6e-18
Identities = 74/311 (23%), Positives = 131/311 (42%), Gaps = 39/311 (12%)
Query: 2 KSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDL---------YRGLTDCCL 52
++N Q A+ AG+ G PFD +K++ Q + Y G+
Sbjct: 11 RNNTKFQVAV---AGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
Query: 53 KTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAA 112
+ + G F+KG PA I +I +V F+ + ++V + + D + +
Sbjct: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAR---EFSVHFVC 124
Query: 113 GSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHG 172
G A+ A L + P ++++ R E K NT+ + ++ R +GP FY G
Sbjct: 125 GGLAACMATLTVHPVDVLRTRFAAQGE-------PKVYNTLRHAVGTMYRSEGPQVFYKG 177
Query: 173 LSSTLLREVPGYFFFFGGYELSRSFF-----ASGRSKDELGPVPLMLSGGVGGICLWLAV 227
L+ TL+ P F Y + + A G+ + L +L G G+
Sbjct: 178 LAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQN---LLCGSGAGVISKTLT 234
Query: 228 YPVDCIKSRIQVLSMSGKQAGF--IRTFIN-------VVKNEGITALYSGLKPTMIRAFP 278
YP+D K R+QV +A F +R + V++ EG + GL P++++A
Sbjct: 235 YPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAAL 294
Query: 279 ANGALFLAYEY 289
+ G +F +YE+
Sbjct: 295 STGFMFFSYEF 305
Score = 71.6 bits (174), Expect = 8e-13
Identities = 54/198 (27%), Positives = 86/198 (43%), Gaps = 7/198 (3%)
Query: 6 AIQAAIDLTAGAAGGTACVLTGQPFDTMKVKM--QTFPDLYRGLTDCCLKTYSQVGFRGF 63
A + ++ G LT P D ++ + Q P +Y L Y G + F
Sbjct: 115 AREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVF 174
Query: 64 YKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALV 123
YKG +P LIA + F CY + + + + + K +LQN GS A + +
Sbjct: 175 YKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGK-KNENLQNLLCGSGAGVISKTL 233
Query: 124 LCPTELVKCRLQT---MYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLRE 180
P +L K RLQ + G++ + + + K +L+K+G LGF+ GLS +LL+
Sbjct: 234 TYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLM-DCAKQVLQKEGALGFFKGLSPSLLKA 292
Query: 181 VPGYFFFFGGYELSRSFF 198
F F YE + F
Sbjct: 293 ALSTGFMFFSYEFFCNVF 310
Score = 58.9 bits (141), Expect = 5e-09
Identities = 42/186 (22%), Positives = 73/186 (39%)
Query: 108 QNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPL 167
Q A AGS + ++ P +++K R Q +E + + + + + IL+++GP
Sbjct: 17 QVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPT 76
Query: 168 GFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAV 227
F+ G + + F +E+ G D + GG+ L V
Sbjct: 77 AFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTV 136
Query: 228 YPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAY 287
+PVD +++R + ++EG Y GL PT+I FP G F Y
Sbjct: 137 HPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCY 196
Query: 288 EYSRKL 293
+ L
Sbjct: 197 SSLKHL 202
Score = 35.8 bits (81), Expect = 0.048
Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 7/88 (7%)
Query: 214 LSGGVGGICLWLAVYPVDCIKSRIQVL-------SMSGKQAGFIRTFINVVKNEGITALY 266
++G V G+ + P D IK R Q+ S K G ++ +++ EG TA +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 267 SGLKPTMIRAFPANGALFLAYEYSRKLM 294
G P I + FL++E +L+
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELV 107
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 88.6 bits (218), Expect = 6e-18
Identities = 74/311 (23%), Positives = 131/311 (42%), Gaps = 39/311 (12%)
Query: 2 KSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDL---------YRGLTDCCL 52
++N Q A+ AG+ G PFD +K++ Q + Y G+
Sbjct: 11 RNNTKFQVAV---AGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
Query: 53 KTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAA 112
+ + G F+KG PA I +I +V F+ + ++V + + D + +
Sbjct: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAR---EFSVHFVC 124
Query: 113 GSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHG 172
G A+ A L + P ++++ R E K NT+ + ++ R +GP FY G
Sbjct: 125 GGLAACMATLTVHPVDVLRTRFAAQGE-------PKVYNTLRHAVGTMYRSEGPQVFYKG 177
Query: 173 LSSTLLREVPGYFFFFGGYELSRSFF-----ASGRSKDELGPVPLMLSGGVGGICLWLAV 227
L+ TL+ P F Y + + A G+ + L +L G G+
Sbjct: 178 LAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQN---LLCGSGAGVISKTLT 234
Query: 228 YPVDCIKSRIQVLSMSGKQAGF--IRTFIN-------VVKNEGITALYSGLKPTMIRAFP 278
YP+D K R+QV +A F +R + V++ EG + GL P++++A
Sbjct: 235 YPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAAL 294
Query: 279 ANGALFLAYEY 289
+ G +F +YE+
Sbjct: 295 STGFMFFSYEF 305
Score = 71.6 bits (174), Expect = 8e-13
Identities = 54/198 (27%), Positives = 86/198 (43%), Gaps = 7/198 (3%)
Query: 6 AIQAAIDLTAGAAGGTACVLTGQPFDTMKVKM--QTFPDLYRGLTDCCLKTYSQVGFRGF 63
A + ++ G LT P D ++ + Q P +Y L Y G + F
Sbjct: 115 AREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVF 174
Query: 64 YKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALV 123
YKG +P LIA + F CY + + + + + K +LQN GS A + +
Sbjct: 175 YKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGK-KNENLQNLLCGSGAGVISKTL 233
Query: 124 LCPTELVKCRLQT---MYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLRE 180
P +L K RLQ + G++ + + + K +L+K+G LGF+ GLS +LL+
Sbjct: 234 TYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLM-DCAKQVLQKEGALGFFKGLSPSLLKA 292
Query: 181 VPGYFFFFGGYELSRSFF 198
F F YE + F
Sbjct: 293 ALSTGFMFFSYEFFCNVF 310
Score = 58.9 bits (141), Expect = 5e-09
Identities = 42/186 (22%), Positives = 73/186 (39%)
Query: 108 QNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPL 167
Q A AGS + ++ P +++K R Q +E + + + + + IL+++GP
Sbjct: 17 QVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPT 76
Query: 168 GFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAV 227
F+ G + + F +E+ G D + GG+ L V
Sbjct: 77 AFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTV 136
Query: 228 YPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAY 287
+PVD +++R + ++EG Y GL PT+I FP G F Y
Sbjct: 137 HPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCY 196
Query: 288 EYSRKL 293
+ L
Sbjct: 197 SSLKHL 202
Score = 35.8 bits (81), Expect = 0.048
Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 7/88 (7%)
Query: 214 LSGGVGGICLWLAVYPVDCIKSRIQVL-------SMSGKQAGFIRTFINVVKNEGITALY 266
++G V G+ + P D IK R Q+ S K G ++ +++ EG TA +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 267 SGLKPTMIRAFPANGALFLAYEYSRKLM 294
G P I + FL++E +L+
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELV 107
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 88.6 bits (218), Expect = 6e-18
Identities = 74/311 (23%), Positives = 131/311 (42%), Gaps = 39/311 (12%)
Query: 2 KSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDL---------YRGLTDCCL 52
++N Q A+ AG+ G PFD +K++ Q + Y G+
Sbjct: 11 RNNTKFQVAV---AGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
Query: 53 KTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAA 112
+ + G F+KG PA I +I +V F+ + ++V + + D + +
Sbjct: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAR---EFSVHFVC 124
Query: 113 GSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHG 172
G A+ A L + P ++++ R E K NT+ + ++ R +GP FY G
Sbjct: 125 GGLAACMATLTVHPVDVLRTRFAAQGE-------PKVYNTLRHAVGTMYRSEGPQVFYKG 177
Query: 173 LSSTLLREVPGYFFFFGGYELSRSFF-----ASGRSKDELGPVPLMLSGGVGGICLWLAV 227
L+ TL+ P F Y + + A G+ + L +L G G+
Sbjct: 178 LAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQN---LLCGSGAGVISKTLT 234
Query: 228 YPVDCIKSRIQVLSMSGKQAGF--IRTFIN-------VVKNEGITALYSGLKPTMIRAFP 278
YP+D K R+QV +A F +R + V++ EG + GL P++++A
Sbjct: 235 YPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAAL 294
Query: 279 ANGALFLAYEY 289
+ G +F +YE+
Sbjct: 295 STGFMFFSYEF 305
Score = 71.6 bits (174), Expect = 8e-13
Identities = 54/198 (27%), Positives = 86/198 (43%), Gaps = 7/198 (3%)
Query: 6 AIQAAIDLTAGAAGGTACVLTGQPFDTMKVKM--QTFPDLYRGLTDCCLKTYSQVGFRGF 63
A + ++ G LT P D ++ + Q P +Y L Y G + F
Sbjct: 115 AREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVF 174
Query: 64 YKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALV 123
YKG +P LIA + F CY + + + + + K +LQN GS A + +
Sbjct: 175 YKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGK-KNENLQNLLCGSGAGVISKTL 233
Query: 124 LCPTELVKCRLQT---MYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLRE 180
P +L K RLQ + G++ + + + K +L+K+G LGF+ GLS +LL+
Sbjct: 234 TYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLM-DCAKQVLQKEGALGFFKGLSPSLLKA 292
Query: 181 VPGYFFFFGGYELSRSFF 198
F F YE + F
Sbjct: 293 ALSTGFMFFSYEFFCNVF 310
Score = 58.9 bits (141), Expect = 5e-09
Identities = 42/186 (22%), Positives = 73/186 (39%)
Query: 108 QNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPL 167
Q A AGS + ++ P +++K R Q +E + + + + + IL+++GP
Sbjct: 17 QVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPT 76
Query: 168 GFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAV 227
F+ G + + F +E+ G D + GG+ L V
Sbjct: 77 AFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTV 136
Query: 228 YPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAY 287
+PVD +++R + ++EG Y GL PT+I FP G F Y
Sbjct: 137 HPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCY 196
Query: 288 EYSRKL 293
+ L
Sbjct: 197 SSLKHL 202
Score = 35.8 bits (81), Expect = 0.048
Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 7/88 (7%)
Query: 214 LSGGVGGICLWLAVYPVDCIKSRIQVL-------SMSGKQAGFIRTFINVVKNEGITALY 266
++G V G+ + P D IK R Q+ S K G ++ +++ EG TA +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 267 SGLKPTMIRAFPANGALFLAYEYSRKLM 294
G P I + FL++E +L+
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELV 107
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 87.8 bits (216), Expect = 1e-17
Identities = 76/290 (26%), Positives = 127/290 (43%), Gaps = 23/290 (7%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQ----TFPDLYRGLTDCCLKTYSQVGFRGFYKGTS 68
L G AGG +T P + +K ++Q + P YRG+ DC +T G G Y+G S
Sbjct: 30 LAGGLAGGIEICITF-PTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLS 88
Query: 69 PALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFAS-AFAALVLCPT 127
L +I + +V F + F +R D Q +L + G A A A +V+CP
Sbjct: 89 SLLYGSIPKAAVRFGMFEFLSNHMR-----DAQGRLDSTRGLLCGLGAGVAEAVVVVCPM 143
Query: 128 ELVKCRL---QTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGY 184
E +K + QT + G + ++ I+R+ G G Y GL++T+L++
Sbjct: 144 ETIKVKFIHDQTSPNPKYRG--------FFHGVREIVREQGLKGTYQGLTATVLKQGSNQ 195
Query: 185 FFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSG 244
F R+++ + P+ + G + G P+D IK+R+Q L +
Sbjct: 196 AIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLE-AH 254
Query: 245 KQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLM 294
K + ++K EG+ A Y G P + R +F+ Y+ KL+
Sbjct: 255 KYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLL 304
Score = 47.8 bits (112), Expect = 1e-05
Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 16 GAAGGTACVLTGQPFDTMKVKMQTFP-DLYRGLTDCCLKTYSQVGFRGFYKGTSPALIAN 74
GA G A V P D +K +MQ YR DC L+ + G + FYKGT P L
Sbjct: 227 GAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRV 286
Query: 75 IAENSVLFMCYGFCQQVVRKV 95
+ +++F+ Y +++ KV
Sbjct: 287 CLDVAIVFVIYDEVVKLLNKV 307
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 84.0 bits (206), Expect = 2e-16
Identities = 82/296 (27%), Positives = 128/296 (43%), Gaps = 29/296 (9%)
Query: 8 QAAIDLTAGAAGGTACVLTGQPFDTMKVKMQ-----TFPDLYRGLTDCCLKTYSQVGFRG 62
+A+ + AG + G + P D +K + Q T P+ Y+ L D + G G
Sbjct: 12 EASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFG 71
Query: 63 FYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAAL 122
FYKG P ++A + +V F + + +K+ G + L A AG + A+
Sbjct: 72 FYKGILPPILAETPKRAVKFFTF----EQYKKLLGYVSLSPA--LTFAIAGLGSGLTEAI 125
Query: 123 VLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDG--PLGFYHGLSSTLLRE 180
V+ P E+VK LQ A+ +TV + I++K+G G GL++TL R
Sbjct: 126 VVNPFEVVKVGLQA-----NRNTFAEQPSTV-GYARQIIKKEGWGLQGLNKGLTATLGRH 179
Query: 181 VPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVG---GICLWLAVYPVDCIKSRI 237
+FG Y ++ +KD + + G+G G + P D KSRI
Sbjct: 180 GVFNMVYFGFYYNVKNMIPV--NKDPI--LEFWRKFGIGLLSGTIASVINIPFDVAKSRI 235
Query: 238 Q---VLSMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYS 290
Q + K +T V + EGI ALY GL P ++R P + L YEY+
Sbjct: 236 QGPQPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYT 291
Score = 41.6 bits (96), Expect = 9e-04
Identities = 42/195 (21%), Positives = 80/195 (41%), Gaps = 8/195 (4%)
Query: 4 NPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGF 63
+PA+ AI AG G + PF+ +KV +Q + + + G+
Sbjct: 107 SPALTFAI---AGLGSGLTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGW 163
Query: 64 -YKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAAL 122
+G + L A + + V M Y V+ + ++K L + G + A++
Sbjct: 164 GLQGLNKGLTATLGRHGVFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASV 223
Query: 123 VLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVP 182
+ P ++ K R+Q G+I T + + ++ +++G L Y GL ++R P
Sbjct: 224 INIPFDVAKSRIQG--PQPVPGEI--KYRTCFKTMATVYQEEGILALYKGLLPKIMRLGP 279
Query: 183 GYFFFFGGYELSRSF 197
G YE + S+
Sbjct: 280 GGAVMLLVYEYTYSW 294
Score = 40.0 bits (92), Expect = 0.003
Identities = 19/85 (22%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMS---GKQAGFIRTFINVVKNEGITALYSGL 269
+++GG G+ ++P+D +K+R Q+ + + +F + + EG+ Y G+
Sbjct: 17 IVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYKGI 76
Query: 270 KPTMIRAFPANGALFLAYEYSRKLM 294
P ++ P F +E +KL+
Sbjct: 77 LPPILAETPKRAVKFFTFEQYKKLL 101
>gi|46409330 solute carrier family 25, member 34 [Homo sapiens]
Length = 304
Score = 81.3 bits (199), Expect = 1e-15
Identities = 75/302 (24%), Positives = 123/302 (40%), Gaps = 25/302 (8%)
Query: 7 IQAAIDLTAGAAGGT-ACVLTGQPFDTMKVKMQ---------TFPDLYRGLTDCCLKTYS 56
+ A+DL GA+ ACV T P + +K ++Q T+P Y G
Sbjct: 4 VPPAVDLVLGASACCLACVFTN-PLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVAR 62
Query: 57 QVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFA 116
G G KG + L+ N V F CY Q AGL +Q AG+ A
Sbjct: 63 ADGLWGLQKGLAAGLLYQGLMNGVRFYCYSLACQ-----AGLTQQPG----GTVVAGAVA 113
Query: 117 SAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSST 176
A A V P L+K +LQ + + TV +++I R+ G LG + G+
Sbjct: 114 GALGAFVGSPAYLIKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGA 173
Query: 177 LLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSR 236
+ R + G + ++++ + E + + G + I + + + P D + +R
Sbjct: 174 VPRVMVGSAAQLATFASAKAWVQKQQWLPEDSWLVALAGGMISSIAVVVVMTPFDVVSTR 233
Query: 237 I--QVLSMSGK---QAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSR 291
+ Q + +G+ G + + + EG ALY GL P +R P L ++ R
Sbjct: 234 LYNQPVDTAGRGQLYGGLTDCMVKIWRQEGPLALYKGLGPAYLRLGPHTILSMLFWDELR 293
Query: 292 KL 293
KL
Sbjct: 294 KL 295
Score = 40.0 bits (92), Expect = 0.003
Identities = 41/192 (21%), Positives = 79/192 (41%), Gaps = 13/192 (6%)
Query: 113 GSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHG 172
G+ A A + P E+VK RLQ E++ G + + + + ++ R DG G G
Sbjct: 13 GASACCLACVFTNPLEVVKTRLQLQGELQARGTYPRPYHGFIASVAAVARADGLWGLQKG 72
Query: 173 LSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDC 232
L++ LL + F Y L+ +G ++ G V ++G V G P
Sbjct: 73 LAAGLLYQGLMNGVRFYCYSLA---CQAGLTQQPGGTV---VAGAVAGALGAFVGSPAYL 126
Query: 233 IKSRIQVLSMSGKQAGFIRTFINVV-------KNEGITALYSGLKPTMIRAFPANGALFL 285
IK+++Q +++ G V+ + +G+ L+ G+ + R + A
Sbjct: 127 IKTQLQAQTVAAVAVGHQHNHQTVLGALETIWRQQGLLGLWQGVGGAVPRVMVGSAAQLA 186
Query: 286 AYEYSRKLMMNQ 297
+ ++ + Q
Sbjct: 187 TFASAKAWVQKQ 198
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 81.3 bits (199), Expect = 1e-15
Identities = 77/286 (26%), Positives = 123/286 (43%), Gaps = 41/286 (14%)
Query: 13 LTAGAAG--GTACVLTGQPFDTMKVKMQTFPD---LYRGLTDCCLKTYSQVGFRGFYKGT 67
+ G AG G CV P D K ++Q + +Y ++DC +KT G+ G Y+G
Sbjct: 13 INGGIAGLIGVTCVF---PIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGA 69
Query: 68 SPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPT 127
+ L E ++ F + + K D Q KL+ L+ AG A +V P
Sbjct: 70 AVNLTLVTPEKAIKLAANDFFRHQLSK----DGQ-KLTLLKEMLAGCGAGTCQVIVTTPM 124
Query: 128 ELVKCRLQTMYEMETSGKIAKSQN--------------------TVWSVIKSILRKDGPL 167
E++K +LQ + KI +Q T + + +LR G
Sbjct: 125 EMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSRGIA 184
Query: 168 GFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGR-SKDELGPVPL-MLSGGVGGICLWL 225
G Y GL +TLLR+VP +F L + GR + +E P + L+G V G +
Sbjct: 185 GLYKGLGATLLRDVPFSVVYF---PLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAAV 241
Query: 226 AVYPVDCIKSRIQVLSMSGKQ---AGFIRTFINVVKNEGITALYSG 268
AV P D +K+R+Q L + +G + ++++EG +A G
Sbjct: 242 AVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
Score = 35.0 bits (79), Expect = 0.081
Identities = 18/61 (29%), Positives = 26/61 (42%), Gaps = 5/61 (8%)
Query: 11 IDLTAGAAGGTACVLTGQPFDTMKVKMQTF-----PDLYRGLTDCCLKTYSQVGFRGFYK 65
+ AG G+A + P D +K ++Q+ D Y G+ DC K G F K
Sbjct: 227 VSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLK 286
Query: 66 G 66
G
Sbjct: 287 G 287
Score = 32.3 bits (72), Expect = 0.53
Identities = 19/81 (23%), Positives = 37/81 (45%), Gaps = 3/81 (3%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQ--AGFIRTFINVVKNEGITALYSGLK 270
+++GG+ G+ V+P+D K+R+Q +G++ I V++EG +Y G
Sbjct: 12 LINGGIAGLIGVTCVFPIDLAKTRLQ-NQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAA 70
Query: 271 PTMIRAFPANGALFLAYEYSR 291
+ P A ++ R
Sbjct: 71 VNLTLVTPEKAIKLAANDFFR 91
>gi|239755176 PREDICTED: similar to solute carrier family 25, member
25 isoform 2 [Homo sapiens]
Length = 469
Score = 78.6 bits (192), Expect = 6e-15
Identities = 67/282 (23%), Positives = 119/282 (42%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYR--GLTDCCLKTYSQVGFRGFYKGTSPA 70
L AG G P D +KV MQ G+ + + G R ++G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 71 LIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A + P E++
Sbjct: 250 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 304
Query: 131 KCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 305 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 356
Query: 191 YELSRSFFASGRSKDELGP--VPLMLSGGVGGICLWLAVYPVDCIKSRIQV-LSMSGK-Q 246
YE ++ + + + P L+ G + C LA YP+ +++R+Q S+ G +
Sbjct: 357 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 416
Query: 247 AGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
F ++++ EG LY GL P ++ PA ++ YE
Sbjct: 417 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 458
Score = 38.1 bits (87), Expect = 0.010
Identities = 20/87 (22%), Positives = 42/87 (48%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+++GG G P+D +K +QV + G + F +++ G +L+ G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 273 MIRAFPANGALFLAYEYSRKLMMNQLE 299
+++ P + F+AYE ++L+ + E
Sbjct: 250 VLKIAPESAIKFMAYEQIKRLVGSDQE 276
>gi|239755174 PREDICTED: similar to solute carrier family 25, member
25 isoform 1 [Homo sapiens]
Length = 503
Score = 78.6 bits (192), Expect = 6e-15
Identities = 67/282 (23%), Positives = 119/282 (42%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYR--GLTDCCLKTYSQVGFRGFYKGTSPA 70
L AG G P D +KV MQ G+ + + G R ++G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 71 LIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A + P E++
Sbjct: 284 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 338
Query: 131 KCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 339 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 390
Query: 191 YELSRSFFASGRSKDELGP--VPLMLSGGVGGICLWLAVYPVDCIKSRIQV-LSMSGK-Q 246
YE ++ + + + P L+ G + C LA YP+ +++R+Q S+ G +
Sbjct: 391 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 450
Query: 247 AGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
F ++++ EG LY GL P ++ PA ++ YE
Sbjct: 451 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 492
Score = 38.1 bits (87), Expect = 0.010
Identities = 20/87 (22%), Positives = 42/87 (48%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+++GG G P+D +K +QV + G + F +++ G +L+ G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 273 MIRAFPANGALFLAYEYSRKLMMNQLE 299
+++ P + F+AYE ++L+ + E
Sbjct: 284 VLKIAPESAIKFMAYEQIKRLVGSDQE 310
>gi|56699407 solute carrier family 25, member 25 isoform c [Homo
sapiens]
Length = 489
Score = 78.6 bits (192), Expect = 6e-15
Identities = 67/282 (23%), Positives = 119/282 (42%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYR--GLTDCCLKTYSQVGFRGFYKGTSPA 70
L AG G P D +KV MQ G+ + + G R ++G
Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 269
Query: 71 LIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A + P E++
Sbjct: 270 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 324
Query: 131 KCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 325 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 376
Query: 191 YELSRSFFASGRSKDELGP--VPLMLSGGVGGICLWLAVYPVDCIKSRIQV-LSMSGK-Q 246
YE ++ + + + P L+ G + C LA YP+ +++R+Q S+ G +
Sbjct: 377 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 436
Query: 247 AGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
F ++++ EG LY GL P ++ PA ++ YE
Sbjct: 437 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 478
Score = 38.1 bits (87), Expect = 0.010
Identities = 20/87 (22%), Positives = 42/87 (48%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+++GG G P+D +K +QV + G + F +++ G +L+ G
Sbjct: 210 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 269
Query: 273 MIRAFPANGALFLAYEYSRKLMMNQLE 299
+++ P + F+AYE ++L+ + E
Sbjct: 270 VLKIAPESAIKFMAYEQIKRLVGSDQE 296
>gi|56699401 solute carrier family 25, member 25 isoform a [Homo
sapiens]
Length = 469
Score = 78.6 bits (192), Expect = 6e-15
Identities = 67/282 (23%), Positives = 119/282 (42%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYR--GLTDCCLKTYSQVGFRGFYKGTSPA 70
L AG G P D +KV MQ G+ + + G R ++G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 71 LIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A + P E++
Sbjct: 250 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 304
Query: 131 KCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 305 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 356
Query: 191 YELSRSFFASGRSKDELGP--VPLMLSGGVGGICLWLAVYPVDCIKSRIQV-LSMSGK-Q 246
YE ++ + + + P L+ G + C LA YP+ +++R+Q S+ G +
Sbjct: 357 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 416
Query: 247 AGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
F ++++ EG LY GL P ++ PA ++ YE
Sbjct: 417 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 458
Score = 38.1 bits (87), Expect = 0.010
Identities = 20/87 (22%), Positives = 42/87 (48%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+++GG G P+D +K +QV + G + F +++ G +L+ G
Sbjct: 190 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 249
Query: 273 MIRAFPANGALFLAYEYSRKLMMNQLE 299
+++ P + F+AYE ++L+ + E
Sbjct: 250 VLKIAPESAIKFMAYEQIKRLVGSDQE 276
>gi|56699405 solute carrier family 25, member 25 isoform d [Homo
sapiens]
Length = 366
Score = 78.6 bits (192), Expect = 6e-15
Identities = 67/282 (23%), Positives = 119/282 (42%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYR--GLTDCCLKTYSQVGFRGFYKGTSPA 70
L AG G P D +KV MQ G+ + + G R ++G
Sbjct: 87 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 146
Query: 71 LIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A + P E++
Sbjct: 147 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 201
Query: 131 KCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 202 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 253
Query: 191 YELSRSFFASGRSKDELGP--VPLMLSGGVGGICLWLAVYPVDCIKSRIQV-LSMSGK-Q 246
YE ++ + + + P L+ G + C LA YP+ +++R+Q S+ G +
Sbjct: 254 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 313
Query: 247 AGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
F ++++ EG LY GL P ++ PA ++ YE
Sbjct: 314 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 355
Score = 38.1 bits (87), Expect = 0.010
Identities = 20/87 (22%), Positives = 42/87 (48%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+++GG G P+D +K +QV + G + F +++ G +L+ G
Sbjct: 87 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 146
Query: 273 MIRAFPANGALFLAYEYSRKLMMNQLE 299
+++ P + F+AYE ++L+ + E
Sbjct: 147 VLKIAPESAIKFMAYEQIKRLVGSDQE 173
>gi|56699403 solute carrier family 25, member 25 isoform b [Homo
sapiens]
Length = 503
Score = 78.6 bits (192), Expect = 6e-15
Identities = 67/282 (23%), Positives = 119/282 (42%), Gaps = 19/282 (6%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYR--GLTDCCLKTYSQVGFRGFYKGTSPA 70
L AG G P D +KV MQ G+ + + G R ++G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 71 LIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELV 130
++ E+++ FM Y + ++++ G D++ L + AGS A A A + P E++
Sbjct: 284 VLKIAPESAIKFMAY----EQIKRLVGSDQET-LRIHERLVAGSLAGAIAQSSIYPMEVL 338
Query: 131 KCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGG 190
K R+ + SG + + IL ++G FY G +L +P
Sbjct: 339 KTRMALRKTGQYSGML--------DCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAV 390
Query: 191 YELSRSFFASGRSKDELGP--VPLMLSGGVGGICLWLAVYPVDCIKSRIQV-LSMSGK-Q 246
YE ++ + + + P L+ G + C LA YP+ +++R+Q S+ G +
Sbjct: 391 YETLKNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPE 450
Query: 247 AGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYE 288
F ++++ EG LY GL P ++ PA ++ YE
Sbjct: 451 VTMSSLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYE 492
Score = 38.1 bits (87), Expect = 0.010
Identities = 20/87 (22%), Positives = 42/87 (48%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+++GG G P+D +K +QV + G + F +++ G +L+ G
Sbjct: 224 LVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGARSLWRGNGIN 283
Query: 273 MIRAFPANGALFLAYEYSRKLMMNQLE 299
+++ P + F+AYE ++L+ + E
Sbjct: 284 VLKIAPESAIKFMAYEQIKRLVGSDQE 310
>gi|60460887 solute carrier family 25, member 42 [Homo sapiens]
Length = 318
Score = 78.2 bits (191), Expect = 8e-15
Identities = 71/298 (23%), Positives = 124/298 (41%), Gaps = 16/298 (5%)
Query: 8 QAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLY--RGLTDCCLKTYSQVGFRGFYK 65
Q L GA G P D K+ Q + + TY GF ++
Sbjct: 32 QVLSSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLNEGFLSLWR 91
Query: 66 GTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLC 125
G S ++ + ++ F + ++++ G +A L AG+ A AA +
Sbjct: 92 GNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEA-LPPWPRLFAGALAGTTAASLTY 150
Query: 126 PTELVKCRLQ-TMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGY 184
P +LV+ R+ T EM ++ ++ V I R++G YHG T+L +P
Sbjct: 151 PLDLVRARMAVTPKEMYSN---------IFHVFIRISREEGLKTLYHGFMPTVLGVIPYA 201
Query: 185 FFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSG 244
F YE +S + + P M+ G G+ A YP+D ++ R+Q ++G
Sbjct: 202 GLSFFTYETLKSLHREYSGRRQPYPFERMIFGACAGLIGQSASYPLDVVRRRMQTAGVTG 261
Query: 245 -KQAGFIRTFINVVKNEG-ITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEA 300
+A RT +V+ EG + LY GL ++ A G F ++ ++M+ L++
Sbjct: 262 YPRASIARTLRTIVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFDL-MQIMLRHLQS 318
>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
Length = 338
Score = 77.0 bits (188), Expect = 2e-14
Identities = 75/300 (25%), Positives = 126/300 (42%), Gaps = 28/300 (9%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTF-PD---LYRGLTDCCLKTYSQVGFRGFYKGTS 68
+TAGA G P D++K +MQ+ PD Y + K GF +G +
Sbjct: 49 MTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVN 108
Query: 69 PALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTE 128
++ +++ F CY + + R + + S L N AGS A+ V+ P E
Sbjct: 109 VMIMGAGPAHAMYFACY---ENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAE 165
Query: 129 LVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFF 188
+VK RLQ MY + I S I+++ R +G FY ++ L +P F
Sbjct: 166 VVKQRLQ-MYNSQHRSAI--------SCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHF 216
Query: 189 GGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKS--------RIQVL 240
YE + R+ P ++SGG+ G A P+D K+ + +
Sbjct: 217 ITYEFLQEQVNPHRT---YNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLA 273
Query: 241 SMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRK-LMMNQLE 299
++SG+ +G F V + G+ + G++ +I P+ + YE+ + L QLE
Sbjct: 274 NISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLE 333
Score = 58.2 bits (139), Expect = 9e-09
Identities = 44/201 (21%), Positives = 86/201 (42%), Gaps = 11/201 (5%)
Query: 13 LTAGAAGGTACVLTG---QPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSP 69
L G AG A +L P + +K ++Q + +R C + G FY+ +
Sbjct: 144 LANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRSAISCIRTVWRTEGLGAFYRSYTT 203
Query: 70 ALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTEL 129
L NI S+ F+ Y F Q+ V + Q+ + +G A A AA P ++
Sbjct: 204 QLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHI------ISGGLAGALAAAATTPLDV 257
Query: 130 VKCRLQTMYEMETS-GKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFF 188
K L T + S I+ + + + +++ + +G G++ G+ + ++ ++P +
Sbjct: 258 CKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISW 317
Query: 189 GGYELSRSFFASGRSKDELGP 209
YE + +F + R + P
Sbjct: 318 SVYEFFK-YFLTKRQLENRAP 337
>gi|115430257 solute carrier family 25, member 26 [Homo sapiens]
Length = 274
Score = 77.0 bits (188), Expect = 2e-14
Identities = 70/286 (24%), Positives = 118/286 (41%), Gaps = 31/286 (10%)
Query: 13 LTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPALI 72
L AG G + L P DT+K ++Q+ + GF G Y G A I
Sbjct: 10 LVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKA-----------GGFHGIYAGVPSAAI 58
Query: 73 ANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELVKC 132
+ + F+ Y + V+ D + L+ +++ A S A L+ P+E+VK
Sbjct: 59 GSFPNAAAFFITYEY----VKWFLHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQ 114
Query: 133 RLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGGYE 192
R Q T + + +IL ++G G Y G ST+LRE+P F +E
Sbjct: 115 RAQVSASTRT-----------FQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWE 163
Query: 193 LSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQA--GFI 250
++ + S R + + G G P+D K+RI + A +
Sbjct: 164 SLKALW-SWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRIMLAKAGSSTADGNVL 222
Query: 251 RTFINVVKNEGITALYSGLKPTMIRAFPANGALFL-AYEYSRKLMM 295
V +++G+ L++G+ P M A G +FL AY+ + L++
Sbjct: 223 SVLHGVWRSQGLAGLFAGVFPRM-AAISLGGFIFLGAYDRTHSLLL 267
Score = 47.8 bits (112), Expect = 1e-05
Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 13/97 (13%)
Query: 205 DELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITA 264
D G V +++GGV G+ + L ++P+D IK+R+Q K GF
Sbjct: 2 DRPGFVAALVAGGVAGVSVDLILFPLDTIKTRLQSPQGFNKAGGF-------------HG 48
Query: 265 LYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEAY 301
+Y+G+ I +FP A F+ YEY + + +Y
Sbjct: 49 IYAGVPSAAIGSFPNAAAFFITYEYVKWFLHADSSSY 85
>gi|13899342 solute carrier [Homo sapiens]
Length = 315
Score = 77.0 bits (188), Expect = 2e-14
Identities = 68/250 (27%), Positives = 106/250 (42%), Gaps = 32/250 (12%)
Query: 13 LTAGAAG--GTACVLTGQPFDTMKVKMQTFPD--LYRGLTDCCLKTYSQVGFRGFYKGTS 68
+ G AG G CV P D K ++Q +Y+G+ DC +KT GF G Y+G +
Sbjct: 13 INGGVAGLVGVTCVF---PIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEGFFGMYRGAA 69
Query: 69 PALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTE 128
L E ++ F ++++ + G+ + K+ L AG A +V CP E
Sbjct: 70 VNLTLVTPEKAIKLAANDFFRRLLME-DGMQRNLKMEML----AGCGAGMCQVVVTCPME 124
Query: 129 LVKCRLQ-----------------TMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYH 171
++K +LQ T T + + + +LR G G Y
Sbjct: 125 MLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYR 184
Query: 172 GLSSTLLREVPGYFFFFGGY-ELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPV 230
GL +TLLR++P +F + L+ F K +SG V G +AV P+
Sbjct: 185 GLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASF--AHSFVSGCVAGSIAAVAVTPL 242
Query: 231 DCIKSRIQVL 240
D +K+RIQ L
Sbjct: 243 DVLKTRIQTL 252
Score = 41.6 bits (96), Expect = 9e-04
Identities = 21/83 (25%), Positives = 37/83 (44%)
Query: 213 MLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPT 272
+++GGV G+ V+P+D K+R+Q G I + + EG +Y G
Sbjct: 12 LINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEGFFGMYRGAAVN 71
Query: 273 MIRAFPANGALFLAYEYSRKLMM 295
+ P A ++ R+L+M
Sbjct: 72 LTLVTPEKAIKLAANDFFRRLLM 94
Score = 39.7 bits (91), Expect = 0.003
Identities = 20/62 (32%), Positives = 29/62 (46%), Gaps = 5/62 (8%)
Query: 10 AIDLTAGAAGGTACVLTGQPFDTMKVKMQTFP-----DLYRGLTDCCLKTYSQVGFRGFY 64
A +G G+ + P D +K ++QT D+Y G+TDC K + Q G F
Sbjct: 222 AHSFVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFM 281
Query: 65 KG 66
KG
Sbjct: 282 KG 283
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,407,655
Number of Sequences: 37866
Number of extensions: 416951
Number of successful extensions: 1284
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 715
Number of HSP's gapped (non-prelim): 197
length of query: 301
length of database: 18,247,518
effective HSP length: 102
effective length of query: 199
effective length of database: 14,385,186
effective search space: 2862652014
effective search space used: 2862652014
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.