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Search of human proteins with 7657319
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens]
(470 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens] 970 0.0
gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens] 811 0.0
gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens] 811 0.0
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot... 392 e-109
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 392 e-109
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 287 1e-77
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 252 6e-67
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 230 2e-60
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 230 2e-60
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 228 9e-60
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 225 6e-59
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 212 5e-55
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 212 5e-55
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 193 3e-49
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 193 3e-49
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 193 3e-49
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 193 3e-49
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 193 3e-49
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 193 3e-49
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 167 2e-41
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 158 9e-39
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 157 2e-38
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 152 8e-37
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 145 1e-34
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 145 1e-34
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 145 1e-34
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 145 1e-34
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 139 4e-33
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 137 3e-32
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 136 5e-32
>gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens]
Length = 470
Score = 970 bits (2507), Expect = 0.0
Identities = 470/470 (100%), Positives = 470/470 (100%)
Query: 1 MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKN 60
MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKN
Sbjct: 1 MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKN 60
Query: 61 NQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPEN 120
NQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPEN
Sbjct: 61 NQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPEN 120
Query: 121 MEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQ 180
MEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQ
Sbjct: 121 MEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQ 180
Query: 181 DPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTL 240
DPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTL
Sbjct: 181 DPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTL 240
Query: 241 IRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK 300
IRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK
Sbjct: 241 IRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK 300
Query: 301 KIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGM 360
KIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGM
Sbjct: 301 KIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGM 360
Query: 361 PDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTT 420
PDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTT
Sbjct: 361 PDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTT 420
Query: 421 PVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE 470
PVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE
Sbjct: 421 PVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE 470
>gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
Length = 391
Score = 811 bits (2095), Expect = 0.0
Identities = 391/391 (100%), Positives = 391/391 (100%)
Query: 80 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 139
MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS
Sbjct: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
Query: 140 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 199
ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI
Sbjct: 61 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 120
Query: 200 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 259
RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI
Sbjct: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
Query: 260 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 319
DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV
Sbjct: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 240
Query: 320 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 379
GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY
Sbjct: 241 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
Query: 380 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 439
LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP
Sbjct: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
Query: 440 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 470
KECTNLCCEALTCKLKPGTDCGGDAPNHTTE
Sbjct: 361 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 391
>gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
Length = 391
Score = 811 bits (2095), Expect = 0.0
Identities = 391/391 (100%), Positives = 391/391 (100%)
Query: 80 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 139
MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS
Sbjct: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
Query: 140 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 199
ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI
Sbjct: 61 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 120
Query: 200 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 259
RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI
Sbjct: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
Query: 260 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 319
DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV
Sbjct: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 240
Query: 320 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 379
GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY
Sbjct: 241 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
Query: 380 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 439
LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP
Sbjct: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
Query: 440 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 470
KECTNLCCEALTCKLKPGTDCGGDAPNHTTE
Sbjct: 361 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 391
>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
[Homo sapiens]
Length = 540
Score = 392 bits (1006), Expect = e-109
Identities = 203/450 (45%), Positives = 290/450 (64%), Gaps = 14/450 (3%)
Query: 18 LLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQ 77
LLPV L++ AIK+ P + +E+V P +LH LHKRE K + ++E++E E++
Sbjct: 5 LLPVS-LLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPE-----QQEQFETELK 58
Query: 78 YQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSV 137
Y+M +NG+ +L L+K K+LL P YTET Y+ G+EITT P+ M+ CYY+G+ILNEK S
Sbjct: 59 YKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSD 118
Query: 138 ASISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST--- 192
ASISTC GLRGYF+ QRY I+PL D +EHA+F N +E++ + TCG+
Sbjct: 119 ASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWA 177
Query: 193 -DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNL 251
D +Q + L + +KYI+ YLVLDN +K YNEN IR VF++ N
Sbjct: 178 HDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANY 237
Query: 252 LNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLS 310
+N++Y ++ VALVGMEIW+D DKIK+ P+AS T +NF +W S L + K HD AQL++
Sbjct: 238 VNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLIT 297
Query: 311 GISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCP 370
VGLA +++CSP SV V++ N + + G M+HE+GH GM ++ KCP
Sbjct: 298 ATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCP 357
Query: 371 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 430
S CVM++ LS P DFS+ R ++++ + CL AP+PT+I++TP+CGN L+E+
Sbjct: 358 STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEM 417
Query: 431 GEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
GEDCDCG+ +ECTN+CC+A TCK+K C
Sbjct: 418 GEDCDCGTSEECTNICCDAKTCKIKATFQC 447
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 392 bits (1006), Expect = e-109
Identities = 203/450 (45%), Positives = 290/450 (64%), Gaps = 14/450 (3%)
Query: 18 LLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQ 77
LLPV L++ AIK+ P + +E+V P +LH LHKRE K + ++E++E E++
Sbjct: 5 LLPVS-LLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPE-----QQEQFETELK 58
Query: 78 YQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSV 137
Y+M +NG+ +L L+K K+LL P YTET Y+ G+EITT P+ M+ CYY+G+ILNEK S
Sbjct: 59 YKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSD 118
Query: 138 ASISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST--- 192
ASISTC GLRGYF+ QRY I+PL D +EHA+F N +E++ + TCG+
Sbjct: 119 ASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWA 177
Query: 193 -DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNL 251
D +Q + L + +KYI+ YLVLDN +K YNEN IR VF++ N
Sbjct: 178 HDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANY 237
Query: 252 LNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLS 310
+N++Y ++ VALVGMEIW+D DKIK+ P+AS T +NF +W S L + K HD AQL++
Sbjct: 238 VNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLIT 297
Query: 311 GISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCP 370
VGLA +++CSP SV V++ N + + G M+HE+GH GM ++ KCP
Sbjct: 298 ATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCP 357
Query: 371 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 430
S CVM++ LS P DFS+ R ++++ + CL AP+PT+I++TP+CGN L+E+
Sbjct: 358 STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEM 417
Query: 431 GEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
GEDCDCG+ +ECTN+CC+A TCK+K C
Sbjct: 418 GEDCDCGTSEECTNICCDAKTCKIKATFQC 447
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 287 bits (735), Expect = 1e-77
Identities = 157/420 (37%), Positives = 238/420 (56%), Gaps = 7/420 (1%)
Query: 43 EIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDY 102
++V PKKL ++ KR+ T + YE E+ Y++ LN + ++L L +++ LG +Y
Sbjct: 28 QLVRPKKLPLIQKRD--TGHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGSNY 85
Query: 103 TETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPL 162
+ET YS +GE T P+ M+HC+Y+G+I++E +S ASISTC+GLRG+F + QRY I+P+
Sbjct: 86 SETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPV 145
Query: 163 KSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDL 222
K +DE EH VF N AN++C + K P + K + +KY++L
Sbjct: 146 KYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVP--GDNESEEDSKIKGIHDEKYVEL 203
Query: 223 YLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPS 282
++V D+ Y+ +R+ ++ ++N +N+IY T+++ V LVG+EIW+ DKI++ +
Sbjct: 204 FIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSN 263
Query: 283 ASTTFDNFLRWHSSNL-GKKIHDHAQLLSGISFNNRRVGLAASNSLCSP-SSVAVIEAKK 340
TT F W L +K DH LLSG + G++ +C P S ++I+
Sbjct: 264 IETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLL 323
Query: 341 KNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYL 400
+ + M+H+LGH LGM F CPSG CVM+ S K FS + + +YL
Sbjct: 324 PDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSDGSIPALK-FSKCSQNQYHQYL 382
Query: 401 LSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
KP C+L P P N CGN L+ GE+CDCG +ECTN CC+A TC LKPG C
Sbjct: 383 KDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTC 442
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 252 bits (643), Expect = 6e-67
Identities = 154/454 (33%), Positives = 234/454 (51%), Gaps = 26/454 (5%)
Query: 22 LWLIVQTQAIAIKQTPELTL---HEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQY 78
LWL+ AI + L +E+V P +L R + H + V Y
Sbjct: 6 LWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPER------VSY 59
Query: 79 QMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVA 138
+ G L L+K + LLG YTET + G E+T +P +HC+Y+G++ +S A
Sbjct: 60 VLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAA 119
Query: 139 SISTCDGLRGYFTHHHQRYQIKPLKSTDEK-EHAVFTSNQEEQDPANHTCGVKSTDGKQG 197
S+STC GLRG+F + I+PL E HAV+ + Q TCGV +D G
Sbjct: 120 SLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAG--TCGV--SDDSLG 175
Query: 198 PIRISRSLK--SPEKEDFL--RAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLN 253
+ R+ P D L R +Y++LY+V+DNA ++ +R V +V+N ++
Sbjct: 176 SLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAA-VRHRVLEVVNHVD 234
Query: 254 VIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKK-IHDHAQLLSGI 312
+Y ++ +V LVG+EIW+ D+ V P S T +N L W + ++ +HD+ QL++G+
Sbjct: 235 KLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGV 294
Query: 313 SFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKC--- 369
F VG A +++CS SS AV + KN V + M+HE+GH LGM C
Sbjct: 295 DFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQ 354
Query: 370 ---PSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNH 426
+G C+M + S FP+ FS +A+ E +L + CL AP ++++ PVCGN
Sbjct: 355 ERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNL 414
Query: 427 LLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
+E GE CDCG P++C N CC + TC+L G C
Sbjct: 415 FVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQC 448
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 230 bits (586), Expect = 2e-60
Identities = 125/386 (32%), Positives = 192/386 (49%), Gaps = 11/386 (2%)
Query: 84 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 143
G+E++L L+K LL P Y ET Y P G+ + P + +HC+Y+G + +S + TC
Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
Query: 144 DGLRGYFT-HHHQRYQIKPLK---STDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 199
G+ G T + Y ++P S D H +F E+ TCG + K G
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF--RMEQLLTWKGTCGHRDPGNKAGMT 191
Query: 200 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 259
+ +S + + R +KY++LY+V D+ + + NL + + +V N ++ + T+
Sbjct: 192 SLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTL 251
Query: 260 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 319
D+QVAL G+E+W++ D+ +V A+ T FL+W ++ HD AQLL+G +F V
Sbjct: 252 DIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATV 311
Query: 320 GLAASNSLC-SPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVP----FNTKCPSGSC 374
GLA +C + SS V + + M+HE+GH LG+ P SG C
Sbjct: 312 GLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGC 371
Query: 375 VMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDC 434
VM FP+ FS R + CL AP P + +CGN +E GE+C
Sbjct: 372 VMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEEC 431
Query: 435 DCGSPKECTNLCCEALTCKLKPGTDC 460
DCG +EC +LCC A C L+PG C
Sbjct: 432 DCGPGQECRDLCCFAHNCSLRPGAQC 457
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 230 bits (586), Expect = 2e-60
Identities = 125/386 (32%), Positives = 192/386 (49%), Gaps = 11/386 (2%)
Query: 84 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 143
G+E++L L+K LL P Y ET Y P G+ + P + +HC+Y+G + +S + TC
Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
Query: 144 DGLRGYFT-HHHQRYQIKPLK---STDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 199
G+ G T + Y ++P S D H +F E+ TCG + K G
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF--RMEQLLTWKGTCGHRDPGNKAGMT 191
Query: 200 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 259
+ +S + + R +KY++LY+V D+ + + NL + + +V N ++ + T+
Sbjct: 192 SLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTL 251
Query: 260 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 319
D+QVAL G+E+W++ D+ +V A+ T FL+W ++ HD AQLL+G +F V
Sbjct: 252 DIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATV 311
Query: 320 GLAASNSLC-SPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVP----FNTKCPSGSC 374
GLA +C + SS V + + M+HE+GH LG+ P SG C
Sbjct: 312 GLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGC 371
Query: 375 VMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDC 434
VM FP+ FS R + CL AP P + +CGN +E GE+C
Sbjct: 372 VMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEEC 431
Query: 435 DCGSPKECTNLCCEALTCKLKPGTDC 460
DCG +EC +LCC A C L+PG C
Sbjct: 432 DCGPGQECRDLCCFAHNCSLRPGAQC 457
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 228 bits (581), Expect = 9e-60
Identities = 131/417 (31%), Positives = 213/417 (51%), Gaps = 13/417 (3%)
Query: 54 HKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEE 113
H+ I +T + E++ + + +++ G E+IL L+K + L P YTET Y+ G
Sbjct: 43 HELIIPQWKTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNP 102
Query: 114 ITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFT-HHHQRYQIKPLKSTDEKEHAV 172
TT + +HC+Y G + + S ++STC G+RG T + Y I+PL + + +H +
Sbjct: 103 QTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDS-KGQHLI 161
Query: 173 FTSNQEEQDPANHTCGV---KSTDGKQGPIRISRSLKSPE--KEDFLRAQKYIDLYLVLD 227
+ S + P N CG K T ++ K P K + L + KY++LYLV D
Sbjct: 162 YRSEHLKPPPGN--CGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVAD 219
Query: 228 NAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTF 287
++ + + + ++ N ++ Y ++++++ALVG+E+W+ G+ +V + +T
Sbjct: 220 YLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTL 279
Query: 288 DNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSP-SSVAVIEAKKKNNVAL 346
+FL W L +K HD+AQL++G+SF+ +GLA ++CS S V +N + +
Sbjct: 280 WSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGV 339
Query: 347 VGVMSHELGHVLGMPDVP---FNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQ 403
M+HE+GH GM + G C+M FPK F+ R +RYL S
Sbjct: 340 AATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSG 399
Query: 404 KPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
CL P + CGN LE GE+CDCG +EC N CC A C L+PG +C
Sbjct: 400 GGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAEC 456
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 225 bits (574), Expect = 6e-59
Identities = 139/455 (30%), Positives = 228/455 (50%), Gaps = 28/455 (6%)
Query: 17 VLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEV 76
+LL ++ ++ +QT L+ +EI+ P +L E+ Y +V
Sbjct: 18 LLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRL-----------TRERREAPRPYSKQV 66
Query: 77 QYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNS 136
Y + G+E I+ L++ K LL D+ Y+ G IT P HC+Y+G + NS
Sbjct: 67 SYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNS 126
Query: 137 VASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQ 196
++S C GLRG + Y I+PL+++ EH ++ + ++P CGV + D ++
Sbjct: 127 SIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLK--CGVSNKDIEK 184
Query: 197 GPIRISRSLKSPEKEDFLRAQ-------KYIDLYLVLDNAFYKNYNENLTLIRSFVFDVM 249
+ + P LR + +Y++L++V+D Y N T +R + +
Sbjct: 185 ETAK-DEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLA 243
Query: 250 NLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNL-GKKIHDHAQL 308
N L+ +Y +++++ LVG+EIW++G+ I +V A NF++W L ++ HD AQL
Sbjct: 244 NYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQL 303
Query: 309 LSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGM-PDVPFN 366
+ F G+A ++CS S I + V +++HELGH LGM D +
Sbjct: 304 VLKKGFGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRD 362
Query: 367 TKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNH 426
C + SC+MN S ++FS+ FE+ L++ CLL P P + P CGN
Sbjct: 363 CSCGAKSCIMNSGASGS--RNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
Query: 427 LLEVGEDCDCGSPKEC-TNLCCEALTCKLKPGTDC 460
L++ GE+CDCG+PKEC + CCE TCKLK +C
Sbjct: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAEC 455
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 212 bits (540), Expect = 5e-55
Identities = 123/414 (29%), Positives = 202/414 (48%), Gaps = 31/414 (7%)
Query: 69 EERYEPEV-QYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPEN---MEHC 124
+ + PEV ++ +E+I++L++ + L+ +TET Y G +++ + HC
Sbjct: 60 DSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHC 119
Query: 125 YYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPAN 184
YY G++ +S S+STC GLRG ++ Y ++P+KS +N+ + PA
Sbjct: 120 YYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSA---------TNRYKLFPAK 170
Query: 185 HTCGVKSTDGKQG--PIRISRSLKSP--------EKEDFLRAQKYIDLYLVLDNAFYKNY 234
V+ + G P ++++ P K + L+A KY++L +V DN ++
Sbjct: 171 KLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQ 230
Query: 235 NENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWH 294
++L ++ + ++ N ++ Y +++++ LVG+E+W+D DK V T+ FL W
Sbjct: 231 GKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWR 290
Query: 295 SSNL-GKKIHDHAQLLSGISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSH 352
L +K HD+AQL+SG+ F +G+A S+C+ S ++ N + ++H
Sbjct: 291 KMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAH 350
Query: 353 ELGHVLGMPDVPFNTKCP------SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPK 406
ELGH GM + C G C+MN FP FS+ R E L
Sbjct: 351 ELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGV 410
Query: 407 CLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
CL P CGN +E GE+CDCG P+EC N CC A TC LKP C
Sbjct: 411 CLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVC 464
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 212 bits (540), Expect = 5e-55
Identities = 123/414 (29%), Positives = 202/414 (48%), Gaps = 31/414 (7%)
Query: 69 EERYEPEV-QYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPEN---MEHC 124
+ + PEV ++ +E+I++L++ + L+ +TET Y G +++ + HC
Sbjct: 60 DSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHC 119
Query: 125 YYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPAN 184
YY G++ +S S+STC GLRG ++ Y ++P+KS +N+ + PA
Sbjct: 120 YYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSA---------TNRYKLFPAK 170
Query: 185 HTCGVKSTDGKQG--PIRISRSLKSP--------EKEDFLRAQKYIDLYLVLDNAFYKNY 234
V+ + G P ++++ P K + L+A KY++L +V DN ++
Sbjct: 171 KLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQ 230
Query: 235 NENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWH 294
++L ++ + ++ N ++ Y +++++ LVG+E+W+D DK V T+ FL W
Sbjct: 231 GKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWR 290
Query: 295 SSNL-GKKIHDHAQLLSGISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSH 352
L +K HD+AQL+SG+ F +G+A S+C+ S ++ N + ++H
Sbjct: 291 KMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAH 350
Query: 353 ELGHVLGMPDVPFNTKCP------SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPK 406
ELGH GM + C G C+MN FP FS+ R E L
Sbjct: 351 ELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGV 410
Query: 407 CLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
CL P CGN +E GE+CDCG P+EC N CC A TC LKP C
Sbjct: 411 CLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVC 464
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 193 bits (490), Expect = 3e-49
Identities = 118/401 (29%), Positives = 200/401 (49%), Gaps = 14/401 (3%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
++ ++ L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G +
Sbjct: 69 LRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAG 128
Query: 136 SVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KST 192
S SI TC GLRG +R D + + + Q+ P HTC + +S
Sbjct: 129 SWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESV 187
Query: 193 DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 252
++ P + D + K ++L +V D++ + Y + L+ +V LL
Sbjct: 188 HTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLL 246
Query: 253 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 311
+ + ++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G
Sbjct: 247 DTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTG 306
Query: 312 ISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-- 367
SF+ VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+
Sbjct: 307 TSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCP 366
Query: 368 ---KCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCG 424
P+ +C+M +FS R E+ LL CL + +P+ CG
Sbjct: 367 CPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCG 425
Query: 425 NHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 465
N +E GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 426 NMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 193 bits (490), Expect = 3e-49
Identities = 118/401 (29%), Positives = 200/401 (49%), Gaps = 14/401 (3%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
++ ++ L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G +
Sbjct: 69 LRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAG 128
Query: 136 SVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KST 192
S SI TC GLRG +R D + + + Q+ P HTC + +S
Sbjct: 129 SWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESV 187
Query: 193 DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 252
++ P + D + K ++L +V D++ + Y + L+ +V LL
Sbjct: 188 HTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLL 246
Query: 253 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 311
+ + ++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G
Sbjct: 247 DTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTG 306
Query: 312 ISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-- 367
SF+ VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+
Sbjct: 307 TSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCP 366
Query: 368 ---KCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCG 424
P+ +C+M +FS R E+ LL CL + +P+ CG
Sbjct: 367 CPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCG 425
Query: 425 NHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 465
N +E GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 426 NMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 193 bits (490), Expect = 3e-49
Identities = 118/401 (29%), Positives = 200/401 (49%), Gaps = 14/401 (3%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
++ ++ L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G +
Sbjct: 69 LRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAG 128
Query: 136 SVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KST 192
S SI TC GLRG +R D + + + Q+ P HTC + +S
Sbjct: 129 SWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESV 187
Query: 193 DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 252
++ P + D + K ++L +V D++ + Y + L+ +V LL
Sbjct: 188 HTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLL 246
Query: 253 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 311
+ + ++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G
Sbjct: 247 DTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTG 306
Query: 312 ISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-- 367
SF+ VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+
Sbjct: 307 TSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCP 366
Query: 368 ---KCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCG 424
P+ +C+M +FS R E+ LL CL + +P+ CG
Sbjct: 367 CPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCG 425
Query: 425 NHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 465
N +E GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 426 NMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 193 bits (490), Expect = 3e-49
Identities = 118/401 (29%), Positives = 200/401 (49%), Gaps = 14/401 (3%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
++ ++ L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G +
Sbjct: 69 LRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAG 128
Query: 136 SVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KST 192
S SI TC GLRG +R D + + + Q+ P HTC + +S
Sbjct: 129 SWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESV 187
Query: 193 DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 252
++ P + D + K ++L +V D++ + Y + L+ +V LL
Sbjct: 188 HTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLL 246
Query: 253 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 311
+ + ++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G
Sbjct: 247 DTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTG 306
Query: 312 ISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-- 367
SF+ VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+
Sbjct: 307 TSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCP 366
Query: 368 ---KCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCG 424
P+ +C+M +FS R E+ LL CL + +P+ CG
Sbjct: 367 CPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCG 425
Query: 425 NHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 465
N +E GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 426 NMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 193 bits (490), Expect = 3e-49
Identities = 118/401 (29%), Positives = 200/401 (49%), Gaps = 14/401 (3%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
++ ++ L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G +
Sbjct: 69 LRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAG 128
Query: 136 SVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KST 192
S SI TC GLRG +R D + + + Q+ P HTC + +S
Sbjct: 129 SWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESV 187
Query: 193 DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 252
++ P + D + K ++L +V D++ + Y + L+ +V LL
Sbjct: 188 HTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLL 246
Query: 253 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 311
+ + ++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G
Sbjct: 247 DTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTG 306
Query: 312 ISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-- 367
SF+ VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+
Sbjct: 307 TSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCP 366
Query: 368 ---KCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCG 424
P+ +C+M +FS R E+ LL CL + +P+ CG
Sbjct: 367 CPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCG 425
Query: 425 NHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 465
N +E GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 426 NMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 193 bits (490), Expect = 3e-49
Identities = 118/401 (29%), Positives = 200/401 (49%), Gaps = 14/401 (3%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
++ ++ L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G +
Sbjct: 69 LRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAG 128
Query: 136 SVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KST 192
S SI TC GLRG +R D + + + Q+ P HTC + +S
Sbjct: 129 SWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESV 187
Query: 193 DGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 252
++ P + D + K ++L +V D++ + Y + L+ +V LL
Sbjct: 188 HTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLL 246
Query: 253 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 311
+ + ++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G
Sbjct: 247 DTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTG 306
Query: 312 ISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-- 367
SF+ VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+
Sbjct: 307 TSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCP 366
Query: 368 ---KCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCG 424
P+ +C+M +FS R E+ LL CL + +P+ CG
Sbjct: 367 CPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCG 425
Query: 425 NHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 465
N +E GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 426 NMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 167 bits (422), Expect = 2e-41
Identities = 123/458 (26%), Positives = 207/458 (45%), Gaps = 48/458 (10%)
Query: 22 LWLIVQTQAIAIKQTP--ELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQ 79
LWL++ + P + +L +IV P+K+ QT + E ++ Y
Sbjct: 4 LWLLLAGLCGLLASRPGFQNSLLQIVIPEKI-----------QTNTNDSSEIEYEQISYI 52
Query: 80 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 139
+ ++ E++ K ++ L ++ LY+ +G T + CYY+GNI +S+ +
Sbjct: 53 IPID-EKLYTVHLKQRYFLADNFMIYLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVT 110
Query: 140 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 199
+STC GLRG + Y I+PL+S E +H ++ E+ D A I
Sbjct: 111 LSTCSGLRGILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIA---------------I 155
Query: 200 RISRSLKSPEKEDFLRAQK------------YIDLYLVLDNAFYKNYNENLTLIRSFVFD 247
I RSLK +D + + Y+++++V+D Y + + ++ + V +
Sbjct: 156 FIDRSLKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIE 215
Query: 248 VMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQ 307
++ L N ++ V + L +E+WSD +KI V A FL W S L + HD A
Sbjct: 216 IVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAY 275
Query: 308 LLSGISFNNRRVGLAASNSLCSP--SSVAVIEAKKKNNVALVGVMSHELGHVLGMP-DVP 364
LL + + R +G ++C S+ + K+ A +++ L LG+ D P
Sbjct: 276 LLIYMDY-PRYLGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDP 334
Query: 365 FNTKCPSGSCVMN-QYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVC 423
+C +C+MN + + S K FS+ F+ ++ + KCL P PVC
Sbjct: 335 KKCQCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVC 394
Query: 424 GNHLLEVGEDCDCGSPKEC-TNLCCEALTCKLKPGTDC 460
GN LE E CDCG+ +C CC+ TC LK G C
Sbjct: 395 GNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKC 432
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 158 bits (400), Expect = 9e-39
Identities = 109/402 (27%), Positives = 194/402 (48%), Gaps = 22/402 (5%)
Query: 69 EERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKG 128
+E E + Y++++ G+ ++L + K+ L ++ YS G + C+Y+G
Sbjct: 38 KEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQG 96
Query: 129 NILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHT-C 187
I SV +STC GLRG + Y I+PL+S+ EH ++ ++ D + +
Sbjct: 97 YIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEK 156
Query: 188 GVKSTDGKQGPIRISRSLKSPE-KEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVF 246
++S D +S L+S E ++DF KYI+++++++ Y + + T++ VF
Sbjct: 157 DIESRD-------LSFKLQSVEPQQDFA---KYIEMHVIVEKQLYNHMGSDTTVVAQKVF 206
Query: 247 DVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHA 306
++ L N I+ + ++ + L +E+W D +KI A+ FLRW +S L + HD A
Sbjct: 207 QLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHDVA 266
Query: 307 QLLSGISFNNRRVGLAASNSLCSPSSV--AVIEAKKKNNVALVGVMSHELGHVLGMPDVP 364
LL +N VG +C + V+ + + +L +++ L +G+
Sbjct: 267 FLLVYREKSN-YVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDD 325
Query: 365 FN-TKCPSGSCVMN-QYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAP-IPTNIMTTP 421
N +C C+MN + + K FS F ++ QK +CL P +
Sbjct: 326 INKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQA 385
Query: 422 VCGNHLLEVGEDCDCGSPKECT---NLCCEALTCKLKPGTDC 460
VCGN LE GE+CDCG+ ++C CC+ TC+ K G++C
Sbjct: 386 VCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNC 427
>gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
Length = 739
Score = 157 bits (397), Expect = 2e-38
Identities = 115/422 (27%), Positives = 195/422 (46%), Gaps = 24/422 (5%)
Query: 50 LHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSP 109
LH+ R+IK+N +E E ++ Y + ++G+ L L K + L ++ Y+
Sbjct: 25 LHVTVPRKIKSNDSEVS------ERKMIYIITIDGQPYTLHLGK-QSFLPQNFLVYTYNE 77
Query: 110 RGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKE 169
G + P M HC+Y+G NS ++S C GLRG+ + Y I+P++S+ E
Sbjct: 78 TGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFE 137
Query: 170 HAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNA 229
H ++ + + + K P ++ L S K +Y+++Y++++ A
Sbjct: 138 HIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVP--LNSQIKNLSKLLPQYLEIYIIVEKA 195
Query: 230 FYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDN 289
Y + + + V+ L+N ++ + V L +E+WS+ ++I A
Sbjct: 196 LYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQR 255
Query: 290 FLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVG- 348
FL W L + HD A LL + + VG ++C+ S A I A + + L G
Sbjct: 256 FLAWKRDYLILRPHDIAYLLV-YRKHPKYVGATFPGTVCNKSYDAGI-AMYPDAIGLEGF 313
Query: 349 --VMSHELGHVLGMP-DVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQ-K 404
+++ LG +G+ D C +C+MN S + ++C H RY +S+ +
Sbjct: 314 SVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFE 373
Query: 405 PKCLLQ----APIPTNIMTTPVCGNHLLEVGEDCDCGSPKECT-NLCCEALTCKLKPGTD 459
KCL + P+ N PVCGN +LE E+CDCG+ EC CC+ TCKLK
Sbjct: 374 TKCLQKLSNLQPLHQN---QPVCGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVK 430
Query: 460 CG 461
CG
Sbjct: 431 CG 432
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 152 bits (383), Expect = 8e-37
Identities = 102/391 (26%), Positives = 176/391 (45%), Gaps = 10/391 (2%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
+ Y + G+ I+ ++ K L Y+ + + +P + CYY G +
Sbjct: 111 LSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPE 170
Query: 136 SVASISTCDG-LRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KS 191
S+ ++STC G G + Y+IKP+ + EH V+ + ++ CG+ K
Sbjct: 171 SLVALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKI 230
Query: 192 TDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNL 251
+ + + +LK + Q++++L +V+DN Y N T ++ VF+V+N+
Sbjct: 231 AHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNI 290
Query: 252 LNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLS 310
++ Y+ ++V V L G++IW+ + + ++F W + NL ++ HD A L
Sbjct: 291 VDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFI 350
Query: 311 GISFNNRRVGLAASNSLC-SPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKC 369
++G+A +C +P + V + V + HELGH LGM C
Sbjct: 351 K-DTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVC 409
Query: 370 PSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLE 429
C+M+ Y K FS A + +S C+ P P NI CGN ++E
Sbjct: 410 ELQWCIMHAY--RKVTTKFSNCSYAQYWDSTIS-SGLCIQPPPYPGNIFRLKYCGNLVVE 466
Query: 430 VGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
GE+CDCG+ ++C C L C L PG C
Sbjct: 467 EGEECDCGTIRQCAKDPCCLLNCTLHPGAAC 497
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 145 bits (365), Expect = 1e-34
Identities = 101/398 (25%), Positives = 183/398 (45%), Gaps = 25/398 (6%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
+ Y + G++ I+ ++ K L Y+ +G + +P +CYY G + +
Sbjct: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
Query: 136 SVASISTC-DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDG 194
S+ S+STC G +G + Y+IKPL + EH V+ + EE+ + G +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE- 170
Query: 195 KQGPIRISRSLKSPEKEDFLRAQ----------KYIDLYLVLDNAFYKNYNENLTLIRSF 244
I+ ++ E ++ + Q + +++ +V+DN Y Y N + +
Sbjct: 171 ------ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLED 224
Query: 245 VFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-H 303
++ ++N+++ I + I V+V L G+EIW++ + I VV + + +W S N+ ++ H
Sbjct: 225 LYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQH 283
Query: 304 DHAQLLSGISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPD 362
D + L + + G+ A +C+P S A++ K ++H LGH LGM
Sbjct: 284 DTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNH 342
Query: 363 VPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPV 422
+C C+M++ + FS F Y + ++ KCLL+ +I
Sbjct: 343 DEDTCRCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTV-ERTKCLLETVHTKDIFNVKR 399
Query: 423 CGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
CGN ++E GE+CDCG K C C C L G+ C
Sbjct: 400 CGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTC 437
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 145 bits (365), Expect = 1e-34
Identities = 101/398 (25%), Positives = 183/398 (45%), Gaps = 25/398 (6%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
+ Y + G++ I+ ++ K L Y+ +G + +P +CYY G + +
Sbjct: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
Query: 136 SVASISTC-DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDG 194
S+ S+STC G +G + Y+IKPL + EH V+ + EE+ + G +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE- 170
Query: 195 KQGPIRISRSLKSPEKEDFLRAQ----------KYIDLYLVLDNAFYKNYNENLTLIRSF 244
I+ ++ E ++ + Q + +++ +V+DN Y Y N + +
Sbjct: 171 ------ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLED 224
Query: 245 VFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-H 303
++ ++N+++ I + I V+V L G+EIW++ + I VV + + +W S N+ ++ H
Sbjct: 225 LYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQH 283
Query: 304 DHAQLLSGISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPD 362
D + L + + G+ A +C+P S A++ K ++H LGH LGM
Sbjct: 284 DTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNH 342
Query: 363 VPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPV 422
+C C+M++ + FS F Y + ++ KCLL+ +I
Sbjct: 343 DEDTCRCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTV-ERTKCLLETVHTKDIFNVKR 399
Query: 423 CGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
CGN ++E GE+CDCG K C C C L G+ C
Sbjct: 400 CGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTC 437
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 145 bits (365), Expect = 1e-34
Identities = 101/398 (25%), Positives = 183/398 (45%), Gaps = 25/398 (6%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
+ Y + G++ I+ ++ K L Y+ +G + +P +CYY G + +
Sbjct: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
Query: 136 SVASISTC-DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDG 194
S+ S+STC G +G + Y+IKPL + EH V+ + EE+ + G +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE- 170
Query: 195 KQGPIRISRSLKSPEKEDFLRAQ----------KYIDLYLVLDNAFYKNYNENLTLIRSF 244
I+ ++ E ++ + Q + +++ +V+DN Y Y N + +
Sbjct: 171 ------ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLED 224
Query: 245 VFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-H 303
++ ++N+++ I + I V+V L G+EIW++ + I VV + + +W S N+ ++ H
Sbjct: 225 LYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQH 283
Query: 304 DHAQLLSGISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPD 362
D + L + + G+ A +C+P S A++ K ++H LGH LGM
Sbjct: 284 DTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNH 342
Query: 363 VPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPV 422
+C C+M++ + FS F Y + ++ KCLL+ +I
Sbjct: 343 DEDTCRCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTV-ERTKCLLETVHTKDIFNVKR 399
Query: 423 CGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
CGN ++E GE+CDCG K C C C L G+ C
Sbjct: 400 CGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTC 437
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 145 bits (365), Expect = 1e-34
Identities = 101/398 (25%), Positives = 183/398 (45%), Gaps = 25/398 (6%)
Query: 76 VQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKN 135
+ Y + G++ I+ ++ K L Y+ +G + +P +CYY G + +
Sbjct: 52 LSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPE 111
Query: 136 SVASISTC-DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDG 194
S+ S+STC G +G + Y+IKPL + EH V+ + EE+ + G +
Sbjct: 112 SLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE- 170
Query: 195 KQGPIRISRSLKSPEKEDFLRAQ----------KYIDLYLVLDNAFYKNYNENLTLIRSF 244
I+ ++ E ++ + Q + +++ +V+DN Y Y N + +
Sbjct: 171 ------ITCRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLED 224
Query: 245 VFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-H 303
++ ++N+++ I + I V+V L G+EIW++ + I VV + + +W S N+ ++ H
Sbjct: 225 LYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQH 283
Query: 304 DHAQLLSGISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPD 362
D + L + + G+ A +C+P S A++ K ++H LGH LGM
Sbjct: 284 DTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNH 342
Query: 363 VPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPV 422
+C C+M++ + FS F Y + ++ KCLL+ +I
Sbjct: 343 DEDTCRCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTV-ERTKCLLETVHTKDIFNVKR 399
Query: 423 CGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
CGN ++E GE+CDCG K C C C L G+ C
Sbjct: 400 CGNGVVEEGEECDCGPLKHCAKDPCCLSNCTLTDGSTC 437
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 139 bits (351), Expect = 4e-33
Identities = 115/451 (25%), Positives = 201/451 (44%), Gaps = 34/451 (7%)
Query: 17 VLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEV 76
+L+P + L + + E +E+ P+KL G+ + V
Sbjct: 16 LLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSF-------------RGEVQGVVSPV 62
Query: 77 QYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNS 136
Y + L G++ +L L + LL ++ GE + P + C Y G++ +S
Sbjct: 63 SYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDS 122
Query: 137 VASISTC-DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGK 195
A+ISTC GLRG F + YQI+PLK++ EH V+ +E+ N CG+ + +
Sbjct: 123 KATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQF--GNQVCGLSDDEIE 180
Query: 196 QGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVI 255
+ + + KY++L L+ D + Y+ N NL+ + + +++
Sbjct: 181 WQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTY 240
Query: 256 YNTIDVQVALVGMEIWSDGDKIKV-VPSASTTFDNFLRWHSSNLGKKIH-DHAQLLSGIS 313
+ + +++ L +E+W+D +KI+V P + F+ + S L ++ D A L
Sbjct: 241 FQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRK 300
Query: 314 FNNRRVGLAAS-NSLCSPSSVAVIEAKKKNNVALVGVMS-HELGHVLGMPDVPFNTKCPS 371
+N+ LA S +CS + N+ S HELGH +GM +C
Sbjct: 301 YND---ALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRG 357
Query: 372 G-SCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 430
+C+M + FS F +++ S CL P ++ CGN ++E
Sbjct: 358 RLNCIMGSGRTG-----FSNCSYISFFKHI-SSGATCLNNIPGLGYVLKR--CGNKIVED 409
Query: 431 GEDCDCGSPKEC-TNLCCEALTCKLKPGTDC 460
E+CDCGS +EC + CC++ CKL+PG +C
Sbjct: 410 NEECDCGSTEECQKDRCCQS-NCKLQPGANC 439
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 137 bits (344), Expect = 3e-32
Identities = 98/401 (24%), Positives = 180/401 (44%), Gaps = 13/401 (3%)
Query: 67 GKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYY 126
G+ + + Y + G++ ++ ++ K L+ Y+ + + + CYY
Sbjct: 52 GRSAKAPGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYY 111
Query: 127 KGNILNEKNSVASISTC-DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANH 185
G + S+ S C G RG Y+I+P++ + EH V+ N E
Sbjct: 112 HGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAM 171
Query: 186 TCGVKSTDGKQGPIRISRS----LKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLI 241
CG+ + + + + L+ D+ +++L +V+++ F+ N++ +
Sbjct: 172 RCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKV 231
Query: 242 RSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKK 301
+ VF V+N+++ +Y + + L+G+EIW+ G+ + S ++F +W +L +
Sbjct: 232 QEDVFLVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMT-SIEQVLNDFSQWKQISLSQL 290
Query: 302 IHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVAL-VGVMSHELGHVLGM 360
HD A + S + +GLA +C P ++ + + +L ++HELGH LGM
Sbjct: 291 QHDAAHMFIKNSLISI-LGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGM 349
Query: 361 PDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCR-AHFERYLLSQKPKCLLQAPIPTNIMT 419
C C+MN + + P + T+C A F + L+Q CL P I
Sbjct: 350 QHDEEFCFCGERGCIMNTF---RVPAEKFTNCSYADFMKTTLNQG-SCLHNPPRLGEIFM 405
Query: 420 TPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
CGN ++E E CDCGS ++C C L C L+PG C
Sbjct: 406 LKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAAC 446
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 136 bits (342), Expect = 5e-32
Identities = 114/435 (26%), Positives = 192/435 (44%), Gaps = 33/435 (7%)
Query: 54 HKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEE 113
H + K +KH K + +Q+ G + IL L LL DY E Y +
Sbjct: 130 HVLDTKARHQQKHNKAVHLA-QASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQ 188
Query: 114 ITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVF 173
+ + EHCYY G+I K+S ++STC+GL G F Y I+PL+ +++
Sbjct: 189 YS---KGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGR 245
Query: 174 TSNQEEQDPANHTCGVKSTDGKQGP----------IRISRSLKSPEKEDFLRAQKYIDLY 223
++ ++ +K+ ++G ++ + +P + F KY++L
Sbjct: 246 PHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIF-EEMKYLELM 304
Query: 224 LVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIY-NTIDVQVALVGMEIWSDGDKIKVVPS 282
+V D+ YK + + +F V+NL++ IY ++ +V LV +E W++ D+I + +
Sbjct: 305 IVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTN 364
Query: 283 ASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPS-SVAVIEAKKK 341
F ++ K+ D L+S ++F+ +R L+ +CS + V V E
Sbjct: 365 PVQMLHEFSKYRQRI--KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLP 422
Query: 342 NNVALVGVMSHELGHVLGMPDVPFNTK----CPS--GSCVMNQYLSSKFPKDFSTSCRAH 395
+A+ V+S L LG+ P + K C G C+M + + FS
Sbjct: 423 --MAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEE-TGVSHSRKFSKCSILE 479
Query: 396 FERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLK 455
+ +L CL PT + CGN +E GE+CDCG EC LCC+ C L
Sbjct: 480 YRDFLQRGGGACLFNR--PTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCK--KCSLS 535
Query: 456 PGTDCG-GDAPNHTT 469
G C G N+T+
Sbjct: 536 NGAHCSDGPCCNNTS 550
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,268,021
Number of Sequences: 37866
Number of extensions: 897604
Number of successful extensions: 2528
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2299
Number of HSP's gapped (non-prelim): 118
length of query: 470
length of database: 18,247,518
effective HSP length: 106
effective length of query: 364
effective length of database: 14,233,722
effective search space: 5181074808
effective search space used: 5181074808
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.