Search of human proteins with 7656861

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
         (739 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7656861 a disintegrin and metalloprotease domain 18 prepropro...  1558   0.0  
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s...   613   e-175
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi...   603   e-172
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   443   e-124
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...   314   2e-85
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   310   2e-84
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   306   4e-83
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   306   4e-83
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   306   4e-83
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   306   4e-83
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...   305   8e-83
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   300   2e-81
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   294   2e-79
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   284   2e-76
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   284   2e-76
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   284   2e-76
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   281   2e-75
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   277   3e-74
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   256   5e-68
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   247   2e-65
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s...   246   4e-65
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   239   5e-63
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   239   5e-63
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   239   5e-63
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   239   5e-63
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...   239   5e-63
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot...   232   8e-61
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   228   2e-59
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   228   2e-59
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   228   2e-59

>gi|7656861 a disintegrin and metalloprotease domain 18
           preproprotein [Homo sapiens]
          Length = 739

 Score = 1558 bits (4035), Expect = 0.0
 Identities = 739/739 (100%), Positives = 739/739 (100%)

Query: 1   MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL 60
           MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
Sbjct: 1   MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL 60

Query: 61  GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF 120
           GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
Sbjct: 61  GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF 120

Query: 121 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSK 180
           ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSK
Sbjct: 121 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSK 180

Query: 181 LLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNE 240
           LLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNE
Sbjct: 181 LLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNE 240

Query: 241 NQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAG 300
           NQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAG
Sbjct: 241 NQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAG 300

Query: 301 IAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNC 360
           IAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNC
Sbjct: 301 IAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNC 360

Query: 361 SMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDY 420
           SMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDY
Sbjct: 361 SMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDY 420

Query: 421 NTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNG 480
           NTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNG
Sbjct: 421 NTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNG 480

Query: 481 RLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLP 540
           RLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLP
Sbjct: 481 RLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLP 540

Query: 541 CERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADG 600
           CERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADG
Sbjct: 541 CERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADG 600

Query: 601 TMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFGSP 660
           TMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFGSP
Sbjct: 601 TMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFGSP 660

Query: 661 GGSIDDGNFQKSGDFYTEKGYNTHWNNWFILSFCIFLPFFIVFTTVIFKRNEISKSCNRE 720
           GGSIDDGNFQKSGDFYTEKGYNTHWNNWFILSFCIFLPFFIVFTTVIFKRNEISKSCNRE
Sbjct: 661 GGSIDDGNFQKSGDFYTEKGYNTHWNNWFILSFCIFLPFFIVFTTVIFKRNEISKSCNRE 720

Query: 721 NAEYNRNSSVVSESDDVGH 739
           NAEYNRNSSVVSESDDVGH
Sbjct: 721 NAEYNRNSSVVSESDDVGH 739


>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
           sapiens]
          Length = 787

 Score =  613 bits (1582), Expect = e-175
 Identities = 308/728 (42%), Positives = 453/728 (62%), Gaps = 32/728 (4%)

Query: 1   MFLLLALLTEL-GRLQAHEGSEGIFLHVTVPRKIKSN---DSEVSERKMIYIITIDGQPY 56
           MF L  LL  L G L +  G +   L + +P KI++N    SE+   ++ YII ID + Y
Sbjct: 1   MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY 60

Query: 57  TLHLGKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRG 116
           T+HL ++ FL  NF++Y YN+ GS+++ S      C+YQG    +P+S VTLS CSGLRG
Sbjct: 61  TVHLKQRYFLADNFMIYLYNQ-GSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRG 119

Query: 117 FLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIK 176
            LQFEN+SYGIEP+ES+  F+H++Y++KN D +++I  ++ S    K+QP    +    K
Sbjct: 120 ILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIF-IDRS---LKEQPMDDNIFISEK 175

Query: 177 N---LSKLLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSS 233
           +   +  L P YLE++I+V+K LYDY GS+ M VT K+++++GL N+MFTQFK+T++LSS
Sbjct: 176 SEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSS 235

Query: 234 LELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVC 293
           LELWS+EN+IST G+AD++LQ+FL WK+ YL LRPHDIAYLL+Y  +P+Y+GA FPGT+C
Sbjct: 236 LELWSDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMC 295

Query: 294 NKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASG 353
              Y AG+A+YP  I LE F+VI+ Q+L L++G++YDD  +C C  +TCIMN E V ++G
Sbjct: 296 ITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNG 355

Query: 354 RKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQ 413
            K FS+CS+  ++ F+S    KCLQ    +Q     +PVCGNG LE NE CDCG + +C 
Sbjct: 356 VKTFSSCSLRSFQNFISNVGVKCLQNKPQMQK-KSPKPVCGNGRLEGNEICDCGTEAQCG 414

Query: 414 FKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVP 473
              CCD+ TC LK   KC  G CC   C++  +G  CR    PECD  E CNG+S  C P
Sbjct: 415 PASCCDFRTCVLKDGAKCYKGLCC-KDCQILQSGVECRPKAHPECDIAENCNGSSPECGP 473

Query: 474 DTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCG- 532
           D   +NG  CK     CY+G C   D +C  +FGKG++ APFAC++E+ S  +R  NCG 
Sbjct: 474 DITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGR 533

Query: 533 FKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGT 592
            +N++ + C  ++++CG+L C  P +     +    +Y++++D VC+++     +     
Sbjct: 534 DRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITV--DYKLPRTVP 591

Query: 593 DNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCN-ATTKCKGKGICNNFGNCQCFPGHRPP 651
           D   V +G+ C     CVN+ C +  ++  + +  + +C G G+C++   C C PG++PP
Sbjct: 592 DPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPP 651

Query: 652 DCKFQFGSPGGSI----DDGNFQKSGDFYTEKGYNTHWNNWFILSFCIFLPFFIVFTTVI 707
           +C  Q  S G SI    D G+  +     TE       N W +L F I LP  IV T ++
Sbjct: 652 NC--QIRSKGFSIFPEEDMGSIMERASGKTE-------NTW-LLGFLIALPILIVTTAIV 701

Query: 708 FKRNEISK 715
             R ++ K
Sbjct: 702 LARKQLKK 709


>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
           sapiens]
          Length = 735

 Score =  603 bits (1556), Expect = e-172
 Identities = 313/751 (41%), Positives = 442/751 (58%), Gaps = 29/751 (3%)

Query: 1   MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL 60
           M+ +L LL+ LG L+     + + + +TVP KI+S   E  E +  Y I I+G+PYT++L
Sbjct: 1   MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 60

Query: 61  GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF 120
            +++FLP NF VY+Y+ TG +  +   F   CHYQGY   +P S V +S C+GLRG LQF
Sbjct: 61  MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 120

Query: 121 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSK 180
           EN+SYGIEP+ESS  FEH+IYQ+K+   +VS+   N   I  +D  +K+      ++ +K
Sbjct: 121 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEPQQDFAK 178

Query: 181 LLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNE 240
               Y+E+++IVEK LY++MGS+   V QK+ Q+IGL N +F  F +T+ILSSLELW +E
Sbjct: 179 ----YIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDE 234

Query: 241 NQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAG 300
           N+I+T+G+A+++L  FL WK  YL+LRPHD+A+LLVYR+   YVGATF G +C+ +Y  G
Sbjct: 235 NKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGG 294

Query: 301 IAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNC 360
           + ++P  I LE  +VI+AQLL L++G+TYDDI +C C  A CIMN EA+  SG KIFSNC
Sbjct: 295 VVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNC 354

Query: 361 SMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQF--KKCC 418
           S  D+ +F+SK +++CL     L P  + Q VCGN  LE+ EECDCG + +C    + CC
Sbjct: 355 SFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCC 414

Query: 419 DYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYAL 478
           D  TC+ K    C  GPCC   C        CR S + ECD  EYCNG+S++C  + Y  
Sbjct: 415 DIATCRFKAGSNCAEGPCC-ENCLFMSKERMCRPSFE-ECDLPEYCNGSSASCPENHYVQ 472

Query: 479 NGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQP 538
            G  C L    C +G C + D QC   FGK  +  P  C+  +NS  + S NCG  +S  
Sbjct: 473 TGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGY 532

Query: 539 LPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVA 598
             CE  ++ CGKL C    K   +    + +Y+ I  H+C+++   S      +   ++ 
Sbjct: 533 TQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHAD--SQKMWIK 590

Query: 599 DGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFG 658
           DGT CG    C N+ C     +GY+C  T KC  +G+CNN  +C C   + PPDC  Q  
Sbjct: 591 DGTSCGSNKVCRNQRCVSSSYLGYDC-TTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSD 649

Query: 659 S-PGGSIDDGNF-------QKSGDFYTEKGYNTHWNNWFILSFCIFLPFFIVFTTVI--- 707
             PGGSID GNF       +     Y E  Y++    W    F +F+PFFI+F  +I   
Sbjct: 650 LWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRW---PFFLFIPFFIIFCVLIAIM 706

Query: 708 FKRNEISKSCNRENAEYNRNSSVVSESDDVG 738
            K N   K    E  +Y+ +    SES+  G
Sbjct: 707 VKVNFQRKKWRTE--DYSSDEQPESESEPKG 735


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  443 bits (1139), Expect = e-124
 Identities = 250/688 (36%), Positives = 371/688 (53%), Gaps = 31/688 (4%)

Query: 43  RKMIYIITIDGQPYTLHLGK-QSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEF 101
           +++ Y+I  +G+ + +HL + +  LP++F+VYTYN+ G+L +  P    HCHY+GY    
Sbjct: 64  KQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGV 123

Query: 102 PNSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIW 161
            NS + LS C GLRG L  EN SYGIEP+++S+ FEHIIY+M +         V+   I 
Sbjct: 124 HNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIE 183

Query: 162 Q---KDQPYKVPLNSQI-KNLSKLLPQ--YLEIYIIVEKALYDYMGSEMMAVTQKIVQVI 215
           +   KD+  + P  +Q+ +    +LPQ  Y+E++I+V+K  YD MG    AV ++++ + 
Sbjct: 184 KETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLA 243

Query: 216 GLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRP-HDIAYL 274
             +++M+    + ++L  LE+W+N N I+  G A D+L  F+ W+  +LI R  HD A L
Sbjct: 244 NYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQL 303

Query: 275 LVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ 334
           ++ +      G  F GTVC++S+  GI ++   I +E F+ I+A  LG N+G+ +DD   
Sbjct: 304 VLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQ-ITVETFASIVAHELGHNLGMNHDDGRD 362

Query: 335 CFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCG 394
           C C   +CIMN     ASG + FS+CS  D+          CL  +      + + P CG
Sbjct: 363 CSCGAKSCIMNS---GASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAY-SAPSCG 418

Query: 395 NGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSI 454
           N ++++ EECDCG   EC+   CC+ +TCKLK   +C  G CC   C     GT CR   
Sbjct: 419 NKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKD-CRFLPGGTLCRGKT 477

Query: 455 DPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAP 514
             ECD  EYCNG+S  C PD +  NG  C+   AYCYNG CQ  D QC  IFG  A+ AP
Sbjct: 478 S-ECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAP 536

Query: 515 FACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQ 574
             CF EVNS  +R  NCGF  ++   C   + LCGKL C    +N  +      V + IQ
Sbjct: 537 KDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQC----ENVQEIPVFGIVPAIIQ 592

Query: 575 DHVCVSIATGSSMR--SDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKG 632
                +   G   +  SD  D   V +GT CG    C N  C    ++ Y+C+   KC G
Sbjct: 593 TPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHG 652

Query: 633 KGICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDGNFQKSGDFYTEKGYNTHWNNWFILS 692
            G+CN+  NC C  G  PP+C+ +    GGS+D      SG  Y E   NT   +  ++ 
Sbjct: 653 HGVCNSNKNCHCENGWAPPNCETK--GYGGSVD------SGPTYNE--MNTALRDGLLVF 702

Query: 693 FCIFLPFFIVFTTVIFKRNEISKSCNRE 720
           F + +P  +    +  KR+++ +S  R+
Sbjct: 703 FFLIVPLIVCAIFIFIKRDQLWRSYFRK 730


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score =  314 bits (805), Expect = 2e-85
 Identities = 198/651 (30%), Positives = 310/651 (47%), Gaps = 28/651 (4%)

Query: 27  VTVPRKIKSND-SEVSERKMIYIITIDGQPYTLHLGKQSFLPQNFL-VYTYNETGSLHSV 84
           V +P K+ S   S  +   + Y +   GQ + +H+  +  L    L V+TY +  +L   
Sbjct: 42  VVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLED 101

Query: 85  SPYFMMHCHYQGYAAEFPNSFVTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQM 143
             +    C+Y GY    P S V  S C  G RG L+   ++Y IEP+  SA FEH++Y++
Sbjct: 102 QLFIPDDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKV 161

Query: 144 KNNDPNVSIL--AVNYSHIWQKDQPYKVPLNSQIKNLSK----LLPQYLEIYIIVEKALY 197
            +N+     +   +    + ++   ++   NS ++  S         +LE+ ++V    +
Sbjct: 162 NSNETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFF 221

Query: 198 DYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFL 257
            Y  S +  V + +  V+ +V++M+ Q    +IL  +E+W N+  +      + +L  F 
Sbjct: 222 IYSQSNISKVQEDVFLVVNIVDSMYQQLGTYIILIGIEIW-NQGNVFPMTSIEQVLNDFS 280

Query: 258 AWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIAMYP-DAIGLEGFSVI 316
            WK+  L    HD A++ +       +G  +   +C    D G+  +  D   L  F+  
Sbjct: 281 QWKQISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSL--FANT 338

Query: 317 IAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKC 376
           +A  LG  +G+ +D+   CFC    CIMN   V A     F+NCS  D+       +  C
Sbjct: 339 VAHELGHTLGMQHDE-EFCFCGERGCIMNTFRVPAEK---FTNCSYADFMKTTLN-QGSC 393

Query: 377 LQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPC 436
           L     L  +   +  CGNG++E  E+CDCG+  +C+   CC  N C L+    C  G C
Sbjct: 394 LHNPPRLGEIFMLKR-CGNGVVEREEQCDCGSVQQCEQDACCLLN-CTLRPGAACAFGLC 451

Query: 437 CTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQ 496
           C   C+   +G  CR+ ++ ECD  E+CNGTS  C  D Y  +G  C   +AYCY  +C 
Sbjct: 452 CKD-CKFMPSGELCRQEVN-ECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCN 508

Query: 497 TTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQP 556
             D  C +IFGK A+ A   C+KE+NS   R  +CG   +  L C   DV CG++ C   
Sbjct: 509 NHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFCGRVQCENV 568

Query: 557 HKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRK 616
                  D  +  +++I    C  I     +R + +D   V DGT+CGP   C++K C  
Sbjct: 569 RDIPLLQDHFTLQHTHINGVTCWGI--DYHLRMNISDIGEVKDGTVCGPGKICIHKKCVS 626

Query: 617 VHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDG 667
           + ++ + C   T C  KGICNN  +C C  G  PP C  Q    GGSID G
Sbjct: 627 LSVLSHVCLPET-CNMKGICNNKHHCHCGYGWSPPYC--QHRGYGGSIDSG 674


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  310 bits (795), Expect = 2e-84
 Identities = 210/723 (29%), Positives = 330/723 (45%), Gaps = 47/723 (6%)

Query: 12  GRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMI-YIITIDGQPYTLHLGKQSFLPQNF 70
           G  QA          V +P K+ S          + Y +   GQ Y +H+     L    
Sbjct: 77  GHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQRYIVHMRVNKLLFAAH 136

Query: 71  L-VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSG-LRGFLQFENISYGIE 128
           L V+TY E  +L    P+    C+Y GY    P S V LS CSG   G LQ  ++ Y I+
Sbjct: 137 LPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIK 196

Query: 129 PVESSARFEHIIYQMKNNDPNV-----SILAVNYSHIWQKDQPYKVPLNSQIKNLSKLLP 183
           P+  SA FEH++Y++ ++D         +     +H  +    Y   L            
Sbjct: 197 PISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQ 256

Query: 184 QYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQI 243
           +++E+ ++V+   Y +  S    V  ++  V+ +V++ +   ++ VIL+ +++W+  N +
Sbjct: 257 RFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPL 316

Query: 244 STSGDADDILQRFLAWKRDYLILR-PHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIA 302
            TSGD D++L+ F  WK   L  R  HD+A+L +       +G  +   +C   ++ G+ 
Sbjct: 317 PTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGVAYVKGICQNPFNTGVD 376

Query: 303 MYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ-CFCLRATCIMNHEAVSASGRKI---FS 358
           ++ D   L  F++ +   LG N+G+ +D  TQ C C    CIM+      + RK+   FS
Sbjct: 377 VFEDN-RLVVFAITLGHELGHNLGMQHD--TQWCVCELQWCIMH------AYRKVTTKFS 427

Query: 359 NCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQ----PVCGNGILESNEECDCGNKNECQF 414
           NCS   Y      +++     L    P +         CGN ++E  EECDCG   +C  
Sbjct: 428 NCSYAQY------WDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAK 481

Query: 415 KKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPD 474
             CC  N C L     C  G CC   C+   +GT CR+ +  ECD  E+CNGTS  C  D
Sbjct: 482 DPCCLLN-CTLHPGAACAFGICCKD-CKFLPSGTLCRQQVG-ECDLPEWCNGTSHQCPDD 538

Query: 475 TYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFK 534
            Y  +G  C +  A+CY   C   D QC +IFG+ A+ A  +C++E+N+   R  +CG  
Sbjct: 539 VYVQDGISCNVN-AFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIV 597

Query: 535 NSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDN 594
            +  + C   D++CG++ C       N  +  +    ++ D  C    T   +     D 
Sbjct: 598 GTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTC--WGTDYHLGMAIPDI 655

Query: 595 AYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCK 654
             V DGT+CGPE  C+ K C  +  +   C   T C  +GICNN  +C C     PP CK
Sbjct: 656 GEVKDGTVCGPEKICIRKKCASMVHLSQACQPKT-CNMRGICNNKQHCHCNHEWAPPYCK 714

Query: 655 FQFGSPGGSIDDGNFQKSGDFYTEKGYNTHWNNWFILSFCI--FLPFFIVFTTVIFKRNE 712
            +    GGS D G   K+      +G N      ++   C+   + F +    V+FK+  
Sbjct: 715 DK--GYGGSADSGPPPKN----NMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRT 768

Query: 713 ISK 715
            SK
Sbjct: 769 KSK 771


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  306 bits (784), Expect = 4e-83
 Identities = 198/634 (31%), Positives = 308/634 (48%), Gaps = 35/634 (5%)

Query: 47  YIITIDGQPYTLHLGKQSFLPQNFL-VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSF 105
           YI+   GQ + +H+  +  L    L V+TY + G++    P+   +C+Y GY    P S 
Sbjct: 54  YILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESL 113

Query: 106 VTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKD 164
           V+LS C  G +G LQ  + +Y I+P+  S  FEH++Y+M + +   S +    S   Q +
Sbjct: 114 VSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMR---SGFMQNE 170

Query: 165 QPYKVPLNSQIKNLSKLLPQYL---------EIYIIVEKALYDYMGSEMMAVTQKIVQVI 215
              ++    +I N ++    Y+         EI ++++  LY         + + +  ++
Sbjct: 171 ITCRMEFE-EIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229

Query: 216 GLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYL 274
            +V+++     + V+L  LE+W+N+N I    D    +  +  WK + +  R  HD ++L
Sbjct: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHL 288

Query: 275 LVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ 334
                     G      +C       I  + +   L  FS+ +A  LG N+G+ +D+ T 
Sbjct: 289 FTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKT-LGTFSIAVAHHLGHNLGMNHDEDT- 346

Query: 335 CFCLRATCIMNHEAVSASGRKIFSNCSMHDY-RYFVSKFETKCLQKLSNLQPLHQNQPVC 393
           C C +  CIM HE      +  FSNCS  D+  Y V +  TKCL +  + + +  N   C
Sbjct: 347 CRCSQPRCIM-HEGNPPITK--FSNCSYGDFWEYTVER--TKCLLETVHTKDIF-NVKRC 400

Query: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKS 453
           GNG++E  EECDCG    C    CC  N C L     C  G CC   C+   +G  CRK 
Sbjct: 401 GNGVVEEGEECDCGPLKHCAKDPCCLSN-CTLTDGSTCAFGLCCKD-CKFLPSGKVCRKE 458

Query: 454 IDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGA 513
           ++ ECD  E+CNGTS  C  D Y  +G  CK    YCY   C   + QC +IFG GA  A
Sbjct: 459 VN-ECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTA 516

Query: 514 PFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYI 573
              C+KE+N+L +R  +CG KN+  + C   DV CG++ C    +  N SD  +  ++  
Sbjct: 517 SETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARF 576

Query: 574 QDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGK 633
            D +C S  T   +   G D   V DGT CG +  C+++ C  + ++  NC+    C  +
Sbjct: 577 NDIMCWS--TDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAF-CNKR 633

Query: 634 GICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDG 667
           GICNN  +C C     PP+C  +    GGS+D G
Sbjct: 634 GICNNKHHCHCNYLWDPPNCLIK--GYGGSVDSG 665


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  306 bits (784), Expect = 4e-83
 Identities = 198/634 (31%), Positives = 308/634 (48%), Gaps = 35/634 (5%)

Query: 47  YIITIDGQPYTLHLGKQSFLPQNFL-VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSF 105
           YI+   GQ + +H+  +  L    L V+TY + G++    P+   +C+Y GY    P S 
Sbjct: 54  YILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESL 113

Query: 106 VTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKD 164
           V+LS C  G +G LQ  + +Y I+P+  S  FEH++Y+M + +   S +    S   Q +
Sbjct: 114 VSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMR---SGFMQNE 170

Query: 165 QPYKVPLNSQIKNLSKLLPQYL---------EIYIIVEKALYDYMGSEMMAVTQKIVQVI 215
              ++    +I N ++    Y+         EI ++++  LY         + + +  ++
Sbjct: 171 ITCRMEFE-EIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229

Query: 216 GLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYL 274
            +V+++     + V+L  LE+W+N+N I    D    +  +  WK + +  R  HD ++L
Sbjct: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHL 288

Query: 275 LVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ 334
                     G      +C       I  + +   L  FS+ +A  LG N+G+ +D+ T 
Sbjct: 289 FTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKT-LGTFSIAVAHHLGHNLGMNHDEDT- 346

Query: 335 CFCLRATCIMNHEAVSASGRKIFSNCSMHDY-RYFVSKFETKCLQKLSNLQPLHQNQPVC 393
           C C +  CIM HE      +  FSNCS  D+  Y V +  TKCL +  + + +  N   C
Sbjct: 347 CRCSQPRCIM-HEGNPPITK--FSNCSYGDFWEYTVER--TKCLLETVHTKDIF-NVKRC 400

Query: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKS 453
           GNG++E  EECDCG    C    CC  N C L     C  G CC   C+   +G  CRK 
Sbjct: 401 GNGVVEEGEECDCGPLKHCAKDPCCLSN-CTLTDGSTCAFGLCCKD-CKFLPSGKVCRKE 458

Query: 454 IDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGA 513
           ++ ECD  E+CNGTS  C  D Y  +G  CK    YCY   C   + QC +IFG GA  A
Sbjct: 459 VN-ECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTA 516

Query: 514 PFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYI 573
              C+KE+N+L +R  +CG KN+  + C   DV CG++ C    +  N SD  +  ++  
Sbjct: 517 SETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARF 576

Query: 574 QDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGK 633
            D +C S  T   +   G D   V DGT CG +  C+++ C  + ++  NC+    C  +
Sbjct: 577 NDIMCWS--TDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAF-CNKR 633

Query: 634 GICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDG 667
           GICNN  +C C     PP+C  +    GGS+D G
Sbjct: 634 GICNNKHHCHCNYLWDPPNCLIK--GYGGSVDSG 665


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  306 bits (784), Expect = 4e-83
 Identities = 198/634 (31%), Positives = 308/634 (48%), Gaps = 35/634 (5%)

Query: 47  YIITIDGQPYTLHLGKQSFLPQNFL-VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSF 105
           YI+   GQ + +H+  +  L    L V+TY + G++    P+   +C+Y GY    P S 
Sbjct: 54  YILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESL 113

Query: 106 VTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKD 164
           V+LS C  G +G LQ  + +Y I+P+  S  FEH++Y+M + +   S +    S   Q +
Sbjct: 114 VSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMR---SGFMQNE 170

Query: 165 QPYKVPLNSQIKNLSKLLPQYL---------EIYIIVEKALYDYMGSEMMAVTQKIVQVI 215
              ++    +I N ++    Y+         EI ++++  LY         + + +  ++
Sbjct: 171 ITCRMEFE-EIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229

Query: 216 GLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYL 274
            +V+++     + V+L  LE+W+N+N I    D    +  +  WK + +  R  HD ++L
Sbjct: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHL 288

Query: 275 LVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ 334
                     G      +C       I  + +   L  FS+ +A  LG N+G+ +D+ T 
Sbjct: 289 FTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKT-LGTFSIAVAHHLGHNLGMNHDEDT- 346

Query: 335 CFCLRATCIMNHEAVSASGRKIFSNCSMHDY-RYFVSKFETKCLQKLSNLQPLHQNQPVC 393
           C C +  CIM HE      +  FSNCS  D+  Y V +  TKCL +  + + +  N   C
Sbjct: 347 CRCSQPRCIM-HEGNPPITK--FSNCSYGDFWEYTVER--TKCLLETVHTKDIF-NVKRC 400

Query: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKS 453
           GNG++E  EECDCG    C    CC  N C L     C  G CC   C+   +G  CRK 
Sbjct: 401 GNGVVEEGEECDCGPLKHCAKDPCCLSN-CTLTDGSTCAFGLCCKD-CKFLPSGKVCRKE 458

Query: 454 IDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGA 513
           ++ ECD  E+CNGTS  C  D Y  +G  CK    YCY   C   + QC +IFG GA  A
Sbjct: 459 VN-ECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTA 516

Query: 514 PFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYI 573
              C+KE+N+L +R  +CG KN+  + C   DV CG++ C    +  N SD  +  ++  
Sbjct: 517 SETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARF 576

Query: 574 QDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGK 633
            D +C S  T   +   G D   V DGT CG +  C+++ C  + ++  NC+    C  +
Sbjct: 577 NDIMCWS--TDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAF-CNKR 633

Query: 634 GICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDG 667
           GICNN  +C C     PP+C  +    GGS+D G
Sbjct: 634 GICNNKHHCHCNYLWDPPNCLIK--GYGGSVDSG 665


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  306 bits (784), Expect = 4e-83
 Identities = 198/634 (31%), Positives = 308/634 (48%), Gaps = 35/634 (5%)

Query: 47  YIITIDGQPYTLHLGKQSFLPQNFL-VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSF 105
           YI+   GQ + +H+  +  L    L V+TY + G++    P+   +C+Y GY    P S 
Sbjct: 54  YILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESL 113

Query: 106 VTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKD 164
           V+LS C  G +G LQ  + +Y I+P+  S  FEH++Y+M + +   S +    S   Q +
Sbjct: 114 VSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMR---SGFMQNE 170

Query: 165 QPYKVPLNSQIKNLSKLLPQYL---------EIYIIVEKALYDYMGSEMMAVTQKIVQVI 215
              ++    +I N ++    Y+         EI ++++  LY         + + +  ++
Sbjct: 171 ITCRMEFE-EIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229

Query: 216 GLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYL 274
            +V+++     + V+L  LE+W+N+N I    D    +  +  WK + +  R  HD ++L
Sbjct: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRMQHDTSHL 288

Query: 275 LVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ 334
                     G      +C       I  + +   L  FS+ +A  LG N+G+ +D+ T 
Sbjct: 289 FTTLGLRGLSGIGAFRGMCTPHRSCAIVTFMNKT-LGTFSIAVAHHLGHNLGMNHDEDT- 346

Query: 335 CFCLRATCIMNHEAVSASGRKIFSNCSMHDY-RYFVSKFETKCLQKLSNLQPLHQNQPVC 393
           C C +  CIM HE      +  FSNCS  D+  Y V +  TKCL +  + + +  N   C
Sbjct: 347 CRCSQPRCIM-HEGNPPITK--FSNCSYGDFWEYTVER--TKCLLETVHTKDIF-NVKRC 400

Query: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKS 453
           GNG++E  EECDCG    C    CC  N C L     C  G CC   C+   +G  CRK 
Sbjct: 401 GNGVVEEGEECDCGPLKHCAKDPCCLSN-CTLTDGSTCAFGLCCKD-CKFLPSGKVCRKE 458

Query: 454 IDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGA 513
           ++ ECD  E+CNGTS  C  D Y  +G  CK    YCY   C   + QC +IFG GA  A
Sbjct: 459 VN-ECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTA 516

Query: 514 PFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYI 573
              C+KE+N+L +R  +CG KN+  + C   DV CG++ C    +  N SD  +  ++  
Sbjct: 517 SETCYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARF 576

Query: 574 QDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGK 633
            D +C S  T   +   G D   V DGT CG +  C+++ C  + ++  NC+    C  +
Sbjct: 577 NDIMCWS--TDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAF-CNKR 633

Query: 634 GICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDG 667
           GICNN  +C C     PP+C  +    GGS+D G
Sbjct: 634 GICNNKHHCHCNYLWDPPNCLIK--GYGGSVDSG 665


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score =  305 bits (782), Expect = 8e-83
 Identities = 210/674 (31%), Positives = 332/674 (49%), Gaps = 35/674 (5%)

Query: 7   LLTELGR-LQAHEGSEGIFLHVTVPRKIK-SNDSEVSERKMIYIITIDGQPYTLHLG-KQ 63
           LL  LG  +  H   E     VT+P K+    + +     + Y++ + G+ + LHL  K+
Sbjct: 22  LLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKR 81

Query: 64  SFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSIC-SGLRGFLQFEN 122
             LP++  V+++ E G L    PY    C+Y G   E  +S  T+S C  GLRG    + 
Sbjct: 82  LLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDA 141

Query: 123 ISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLL 182
             Y IEP+++S  FEH++Y +K       +  ++   I  +  PY+     +    S   
Sbjct: 142 KHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKH 201

Query: 183 PQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQ 242
           P+YLE+ ++ +++ Y ++ + +  V    + + G+++T F   ++ + L +LE+W++ N+
Sbjct: 202 PKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNK 261

Query: 243 ISTS-GDADDILQRFLAWKRDYLILR-PHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAG 300
           I     +  ++L RF+ +K+  L  R   D A+L + RK+   +  +F G VC+  Y   
Sbjct: 262 IRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSF-GKVCSLEYAGS 320

Query: 301 IAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCL-RATCIMNHEAVSASGRKIFSN 359
           ++   D   +   +   A  LG  VG+++D+   C C  R  CIM       SGR  FSN
Sbjct: 321 VSTLLDT-NILAPATWSAHELGHAVGMSHDE-QYCQCRGRLNCIMG------SGRTGFSN 372

Query: 360 CSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCD 419
           CS   +   +S   T CL  +  L  + +    CGN I+E NEECDCG+  ECQ  +CC 
Sbjct: 373 CSYISFFKHISSGAT-CLNNIPGLGYVLKR---CGNKIVEDNEECDCGSTEECQKDRCCQ 428

Query: 420 YNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALN 479
            N CKL+    C  G CC   C    +G  CR+    ECD  EYC+G SS+C  D Y  +
Sbjct: 429 SN-CKLQPGANCSIGLCC-HDCRFRPSGYVCRQE-GNECDLAEYCDGNSSSCPNDVYKQD 485

Query: 480 GRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENC---GFKNS 536
           G  CK     C+   C++   QC  IFG  A  AP  C+  VN + ++  NC   G +N 
Sbjct: 486 GTPCKY-EGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNF 544

Query: 537 QPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATG--SSMRSDG-TD 593
           +   CE  + +CG+L C+      +  +  + + +++Q    +   TG   SM+  G  D
Sbjct: 545 K--KCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPD 602

Query: 594 NAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDC 653
              + DGT CG    C  K C    ++ ++C    KC  +G+CNN  NC C  G  PP C
Sbjct: 603 LGMINDGTSCGEGRVCFKKNCVNSSVLQFDC-LPEKCNTRGVCNNRKNCHCMYGWAPPFC 661

Query: 654 KFQFGSPGGSIDDG 667
           + + G  GGSID G
Sbjct: 662 E-EVGY-GGSIDSG 673


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  300 bits (769), Expect = 2e-81
 Identities = 219/702 (31%), Positives = 322/702 (45%), Gaps = 56/702 (7%)

Query: 1   MFLLLALLTELGRLQAHEGSEGIFLHVTV---PRKIKSNDSEVSERKM-IYIITIDGQPY 56
           + LLL  +   G LQ H   + +  H  +   P +  S +  VS+  M +  +  +GQ  
Sbjct: 18  LLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQEL 77

Query: 57  TLHLGKQS-FLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLR 115
            L L K    L   ++   Y   G    ++P    HCHYQG    FP+S+V L  CSG+ 
Sbjct: 78  LLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMS 137

Query: 116 GFLQFE-NISYGIEP--VESSARFE-HIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPL 171
           G +    N SY + P     S  F  H I++M+        L         +D   K  +
Sbjct: 138 GLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQ-------LLTWKGTCGHRDPGNKAGM 190

Query: 172 NS-------QIKNLSKLLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQ 224
            S       + +  ++   +YLE+YI+ +  L+      +    Q++++V   V+ +   
Sbjct: 191 TSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250

Query: 225 FKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHP-KY 283
             + V L+ LE+W+  ++   + DA+  L  FL W+R     RPHD A LL  R      
Sbjct: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGAT 310

Query: 284 VGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRAT-- 341
           VG      +C      G++     + + G +  +A  +G ++GL++D    C    A   
Sbjct: 311 VGLAPVEGMCRAESSGGVSTDHSELPI-GAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369

Query: 342 -CIMNHEAVSASGR---KIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGI 397
            C+M     +A+G    ++FS CS    R F  K    CL    +   L     +CGNG 
Sbjct: 370 GCVM----AAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPD-PGLPVPPALCGNGF 424

Query: 398 LESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPE 457
           +E+ EECDCG   EC+   CC  + C L+   +C  G CC  +C L  AG  CR+++  +
Sbjct: 425 VEAGEECDCGPGQECR-DLCCFAHNCSLRPGAQCAHGDCCV-RCLLKPAGALCRQAMG-D 481

Query: 458 CDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFAC 517
           CD  E+C GTSS+C PD Y L+G  C  G+ YC++G C T + QC +++G G+  AP AC
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541

Query: 518 FKEVNSLHERSENCG-FKNSQPLPCERKDVLCGKLAC-------VQPHKNANKSDAQSTV 569
           F+ VNS  +   NCG       LPC  +D LCGKL C       + PH         STV
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPH----MVPVDSTV 597

Query: 570 YSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTK 629
           +   Q+  C       S + D      V  GT CGP M C ++ CRK           T 
Sbjct: 598 HLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQ-RCLTA 656

Query: 630 CKGKGICNNFGNCQCFPGHRPPDC-KFQFGSPGGSIDDGNFQ 670
           C   G+CN+  NC C PG  PP C K  F   GGS+D G  Q
Sbjct: 657 CHSHGVCNSNHNCHCAPGWAPPFCDKPGF---GGSMDSGPVQ 695


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  294 bits (753), Expect = 2e-79
 Identities = 200/677 (29%), Positives = 314/677 (46%), Gaps = 42/677 (6%)

Query: 16  AHEGSEGIFLHVTVPRKIKSNDSEVSER---KMIYIITIDGQPYTLHLGK--QSFLPQNF 70
           + EGS  +   + +P+  K+++S V E+   K    +  +G+   L L K  Q F P ++
Sbjct: 34  SEEGSPKLQHELIIPQW-KTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAP-SY 91

Query: 71  LVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQFE-NISYGIEP 129
               Y  +G+  + +     HC Y G   E   S VTLS C G+RG +    N+SY IEP
Sbjct: 92  TETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEP 151

Query: 130 VESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKD-------QPYKVPLNSQIKNLSKLL 182
           +  S + +H+IY+ ++  P        +S    +D       Q  K P   + ++L+ + 
Sbjct: 152 LPDS-KGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSM- 209

Query: 183 PQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQ 242
            +Y+E+Y++ +   +     +  A   K++++   V+  +    + + L  LE+W++ N 
Sbjct: 210 -KYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNM 268

Query: 243 ISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRK-HPKYVGATFPGTVCNKSYDAGI 301
              S +    L  FL+W+R  L  + HD A L+     H   +G      +C+     G+
Sbjct: 269 CEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGV 328

Query: 302 AMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRAT--CIMNHEAVSASGR---KI 356
            M      + G +  +A  +G N G+T+D    C    A   CIM     +A+G    K+
Sbjct: 329 NMDHSENAI-GVAATMAHEMGHNFGMTHDSADCCSASAADGGCIM----AAATGHPFPKV 383

Query: 357 FSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKK 416
           F+ C+  +   ++      CL  + + + L+  +  CGNG LE  EECDCG + EC    
Sbjct: 384 FNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRR-CGNGYLEDGEECDCGEEEECN-NP 441

Query: 417 CCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTY 476
           CC+ + C L+   +C  G CC  +C+L   GT CR+    +CD  E+C G S +C  + Y
Sbjct: 442 CCNASNCTLRPGAECAHGSCC-HQCKLLAPGTLCREQAR-QCDLPEFCTGKSPHCPTNFY 499

Query: 477 ALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCG-FKN 535
            ++G  C+ G AYCYNG C T   QC +++G GA+ AP  CF++VN   +   NCG   N
Sbjct: 500 QMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMN 559

Query: 536 SQPLPCERKDVLCGKLACVQPHKNANKSDA---QSTVYSYIQDHVC--VSIATGSSMRSD 590
            +   C  +D  CGK+ C        +S+A    +T+    +   C    +  G     D
Sbjct: 560 GEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGD 619

Query: 591 GTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRP 650
             D   V  GT CG    C    CR             KC G G+CNN  NC C PG  P
Sbjct: 620 MLDPGLVMTGTKCGYNHICFEGQCRNTSFFETE-GCGKKCNGHGVCNNNQNCHCLPGWAP 678

Query: 651 PDCKFQFGSPGGSIDDG 667
           P C       GGSID G
Sbjct: 679 PFCNTP--GHGGSIDSG 693


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  284 bits (727), Expect = 2e-76
 Identities = 192/616 (31%), Positives = 285/616 (46%), Gaps = 63/616 (10%)

Query: 91  HCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMK------ 144
           HC+Y G+   + +S V+LS CSGLRG + FEN SY +EP++S+     +    K      
Sbjct: 118 HCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRG 177

Query: 145 -----NNDPNVSILAV--NYSHIWQKDQPYKVPLNSQIKNLSKLLPQYLEIYIIVEKALY 197
                +N PN++   V    S  W +            K  +    +Y+E+ I+ +   +
Sbjct: 178 SCGSHHNTPNLAAKNVFPPPSQTWARRH----------KRETLKATKYVELVIVADNREF 227

Query: 198 DYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFL 257
              G ++  V Q+++++   V+  +    + ++L  +E+W++ ++ S S D    L  FL
Sbjct: 228 QRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFL 287

Query: 258 AWKRDYLILRP-HDIAYLLVYRKHPKYVGATFPGT---------VCNKSYDAGIAMYPDA 307
            W++  L+ R  HD A L+         G  F GT         +C      GI M    
Sbjct: 288 DWRKMKLLPRKSHDNAQLVS--------GVYFQGTTIGMAPIMSMCTADQSGGIVMDHSD 339

Query: 308 IGLEGFSVIIAQLLGLNVGLTYDDITQ-CFCLRAT----CIMNHEAVSASGRKIFSNCSM 362
             L G +V +A  LG N G+ +D + + C C  A     CIMN  +       +FS+CS 
Sbjct: 340 NPL-GAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMN-ASTGYPFPMVFSSCSR 397

Query: 363 HDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDYNT 422
            D    + K    CL  L  ++     Q  CGN  +E  EECDCG   EC   +CC+  T
Sbjct: 398 KDLETSLEKGMGVCLFNLPEVRESFGGQK-CGNRFVEEGEECDCGEPEECM-NRCCNATT 455

Query: 423 CKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRL 482
           C LK    C  G CC   C+L  AGT CR S +  CD  E+C G S +C  + Y  +G  
Sbjct: 456 CTLKPDAVCAHGLCCED-CQLKPAGTACRDSSN-SCDLPEFCTGASPHCPANVYLHDGHS 513

Query: 483 CKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCG-FKNSQPLPC 541
           C+    YCYNG CQT + QC  ++G GA+ AP  CF+ VNS  +   NCG    S    C
Sbjct: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573

Query: 542 ERKDVLCGKLAC----VQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYV 597
           E +D  CGK+ C     +P    N    ++ +    Q    +   T   +  D  D   V
Sbjct: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNI-PLQQGGRILCRGTHVYLGDDMPDPGLV 632

Query: 598 ADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDC-KFQ 656
             GT C     C+N+ C+ + + G +     +C G+G+CNN  NC C     PP C KF 
Sbjct: 633 LAGTKCADGKICLNRQCQNISVFGVH-ECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691

Query: 657 FGSPGGSIDDGNFQKS 672
           F   GGS D G  +++
Sbjct: 692 F---GGSTDSGPIRQA 704


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  284 bits (727), Expect = 2e-76
 Identities = 192/616 (31%), Positives = 285/616 (46%), Gaps = 63/616 (10%)

Query: 91  HCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMK------ 144
           HC+Y G+   + +S V+LS CSGLRG + FEN SY +EP++S+     +    K      
Sbjct: 118 HCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRG 177

Query: 145 -----NNDPNVSILAV--NYSHIWQKDQPYKVPLNSQIKNLSKLLPQYLEIYIIVEKALY 197
                +N PN++   V    S  W +            K  +    +Y+E+ I+ +   +
Sbjct: 178 SCGSHHNTPNLAAKNVFPPPSQTWARRH----------KRETLKATKYVELVIVADNREF 227

Query: 198 DYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFL 257
              G ++  V Q+++++   V+  +    + ++L  +E+W++ ++ S S D    L  FL
Sbjct: 228 QRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFL 287

Query: 258 AWKRDYLILRP-HDIAYLLVYRKHPKYVGATFPGT---------VCNKSYDAGIAMYPDA 307
            W++  L+ R  HD A L+         G  F GT         +C      GI M    
Sbjct: 288 DWRKMKLLPRKSHDNAQLVS--------GVYFQGTTIGMAPIMSMCTADQSGGIVMDHSD 339

Query: 308 IGLEGFSVIIAQLLGLNVGLTYDDITQ-CFCLRAT----CIMNHEAVSASGRKIFSNCSM 362
             L G +V +A  LG N G+ +D + + C C  A     CIMN  +       +FS+CS 
Sbjct: 340 NPL-GAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMN-ASTGYPFPMVFSSCSR 397

Query: 363 HDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDYNT 422
            D    + K    CL  L  ++     Q  CGN  +E  EECDCG   EC   +CC+  T
Sbjct: 398 KDLETSLEKGMGVCLFNLPEVRESFGGQK-CGNRFVEEGEECDCGEPEECM-NRCCNATT 455

Query: 423 CKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRL 482
           C LK    C  G CC   C+L  AGT CR S +  CD  E+C G S +C  + Y  +G  
Sbjct: 456 CTLKPDAVCAHGLCCED-CQLKPAGTACRDSSN-SCDLPEFCTGASPHCPANVYLHDGHS 513

Query: 483 CKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCG-FKNSQPLPC 541
           C+    YCYNG CQT + QC  ++G GA+ AP  CF+ VNS  +   NCG    S    C
Sbjct: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573

Query: 542 ERKDVLCGKLAC----VQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYV 597
           E +D  CGK+ C     +P    N    ++ +    Q    +   T   +  D  D   V
Sbjct: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNI-PLQQGGRILCRGTHVYLGDDMPDPGLV 632

Query: 598 ADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDC-KFQ 656
             GT C     C+N+ C+ + + G +     +C G+G+CNN  NC C     PP C KF 
Sbjct: 633 LAGTKCADGKICLNRQCQNISVFGVH-ECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691

Query: 657 FGSPGGSIDDGNFQKS 672
           F   GGS D G  +++
Sbjct: 692 F---GGSTDSGPIRQA 704


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  284 bits (727), Expect = 2e-76
 Identities = 193/663 (29%), Positives = 315/663 (47%), Gaps = 36/663 (5%)

Query: 5   LALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDS-EVSERKMIYIITIDGQPYTLHLGK- 62
           ++ + EL  ++ +E    I LH    R+ K  +  E  E ++ Y +TI+G+   L+L K 
Sbjct: 16  VSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKN 75

Query: 63  QSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQFEN 122
           ++ L   +    YN TG   + SP  M  C+YQG+      S  ++S C GLRG+    +
Sbjct: 76  KNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGD 135

Query: 123 ISYGIEPVESSARF--EHIIYQMKNNDPNVSILAVNYSHIWQKD--QPYKVPLNSQIKNL 178
             Y IEP+    R   EH +++   ++ N          +W  D  Q   +P    +K  
Sbjct: 136 QRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLK 195

Query: 179 SKLLPQ---YLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLE 235
            + + +   Y+E Y++++   +         + +++ ++   VN ++ +    V L  +E
Sbjct: 196 DRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGME 255

Query: 236 LWSNENQISTSGDADDILQRFLAWKRDYLILRP-HDIAYLLVYRKHP-KYVGATFPGTVC 293
           +W+++++I  + +A   L+ F  W+   L  R  HDIA L+   +     VG  F  T+C
Sbjct: 256 IWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMC 315

Query: 294 NKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASG 353
           +  Y  G+     +  L   +  +A  +G N G+ +DD + C C    C+M+ +A+S   
Sbjct: 316 SP-YSVGVVQ-DHSDNLLRVAGTMAHEMGHNFGMFHDDYS-CKCPSTICVMD-KALSFYI 371

Query: 354 RKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQN---QPVCGNGILESNEECDCGNKN 410
              FS+CS   Y  F   FE K    L N  PL  +    P+CGN ++E  E+CDCG   
Sbjct: 372 PTDFSSCSRLSYDKF---FEDKLSNCLFNA-PLPTDIISTPICGNQLVEMGEDCDCGTSE 427

Query: 411 ECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSN 470
           EC    CCD  TCK+K + +C  G CC  KC+   AG  CR + D ECD  E CNG S N
Sbjct: 428 ECT-NICCDAKTCKIKATFQCALGECC-EKCQFKKAGMVCRPAKD-ECDLPEMCNGKSGN 484

Query: 471 CVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSEN 530
           C  D + +NG  C  G  +C  G C T   QC +++G G + A  +C+   N    +   
Sbjct: 485 CPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNR-NEGGSKYGY 543

Query: 531 CGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSD 590
           C   +   +PC+  D +CGKL C      ++    +  + +++    C +     + +  
Sbjct: 544 CRRVDDTLIPCKANDTMCGKLFC---QGGSDNLPWKGRIVTFL---TCKTFDPEDTSQEI 597

Query: 591 GTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRP 650
           G     VA+GT CG    C+N  C  +     + N ++KCKG  +C++   CQC  G  P
Sbjct: 598 G----MVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIP 653

Query: 651 PDC 653
           PDC
Sbjct: 654 PDC 656


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  281 bits (719), Expect = 2e-75
 Identities = 182/622 (29%), Positives = 295/622 (47%), Gaps = 25/622 (4%)

Query: 42  ERKMIYIITIDGQPYTLHLGK-QSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAE 100
           E +++Y I ++ +   LHL + + FL  N+    Y+  G   +  P  M HC YQG    
Sbjct: 56  EEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVH 115

Query: 101 FPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHI 160
             +S  ++S C+GLRGF +  +  Y IEPV+ S   EH++++     P       NYS  
Sbjct: 116 EYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVP----YGANYSCT 171

Query: 161 WQKDQPYKVPLNSQIKNLSKLL----PQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIG 216
                   VP +++ +  SK+      +Y+E++I+ +  +Y   G     +  +I  ++ 
Sbjct: 172 ELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVN 231

Query: 217 LVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLV 276
            VN ++    + V L  +E+W++E++I    + +  L RF  W+   L  R      +L+
Sbjct: 232 FVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLL 291

Query: 277 YRK--HPKYVGATFPGTVCNKSYDAGIA--MYPDAIGLEGFSVIIAQLLGLNVGLTYDDI 332
             K  +    G ++PG +C   Y   I   + PD   +      +A  LG N+G+ +D+ 
Sbjct: 292 SGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANR---MAHQLGHNLGMQHDEF 348

Query: 333 TQCFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPV 392
             C C    C+M+ +    + +  FS CS + Y  ++  ++  C+  +      H  Q  
Sbjct: 349 P-CTCPSGKCVMDSDGSIPALK--FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQ-F 404

Query: 393 CGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRK 452
           CGN  L+  EECDCG   EC    CCD +TC LK    C  G CC S C++  AG+ CR 
Sbjct: 405 CGNKKLDEGEECDCGPAQECT-NPCCDAHTCVLKPGFTCAEGECCES-CQIKKAGSICRP 462

Query: 453 SIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQG 512
           + D ECDF E C G S  C  D + +NG  CK    YC+ G+C T ++QC+++F   A  
Sbjct: 463 AKD-ECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIE 521

Query: 513 APFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSY 572
           +   C+K +N+   +   C  K ++ LPCE KDV CGK+ C     ++   + ++     
Sbjct: 522 SHDICYK-MNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKD 580

Query: 573 IQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKG 632
            Q +  V   T   +  D TD   VA GT CG  M C N  C  +  +  + N  ++C  
Sbjct: 581 PQKNATVKCKT-IFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNE 639

Query: 633 KGICNNFGNCQCFPGHRPPDCK 654
             +  +   C C  G  P  C+
Sbjct: 640 NPVDGHGLQCHCEEGQAPVACE 661


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  277 bits (708), Expect = 3e-74
 Identities = 212/702 (30%), Positives = 313/702 (44%), Gaps = 82/702 (11%)

Query: 1   MFLLLALLTELGRLQAHEGSEGIFLHVTV---PRKIKSNDSEVSERKM-IYIITIDGQPY 56
           + LLL  +   G LQ H   + +  H  +   P +  S +  VS+  M +  +  +GQ  
Sbjct: 18  LLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQEL 77

Query: 57  TLHLGKQS-FLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLR 115
            L L K    L   ++   Y   G    ++P    HCHYQG    FP+S+V L  CSG+ 
Sbjct: 78  LLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMS 137

Query: 116 GFLQFE-NISYGIEP--VESSARFE-HIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPL 171
           G +    N SY + P     S  F  H I++M+        L         +D   K  +
Sbjct: 138 GLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQ-------LLTWKGTCGHRDPGNKAGM 190

Query: 172 NS-------QIKNLSKLLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQ 224
            S       + +  ++   +YLE+YI+ +  L+      +    Q++++V   V+ +   
Sbjct: 191 TSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250

Query: 225 FKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLVYRKHP-KY 283
             + V L+ LE+W+  ++   + DA+  L  FL W+R     RPHD A LL  R      
Sbjct: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGAT 310

Query: 284 VGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRAT-- 341
           VG      +C      G++     + + G +  +A  +G ++GL++D    C    A   
Sbjct: 311 VGLAPVEGMCRAESSGGVSTDHSELPI-GAAATMAHEIGHSLGLSHDPDGCCVEAAAESG 369

Query: 342 -CIMNHEAVSASGR---KIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGI 397
            C+M     +A+G    ++FS CS    R F  K    CL    +   L     +CGNG 
Sbjct: 370 GCVM----AAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPD-PGLPVPPALCGNGF 424

Query: 398 LESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPE 457
           +E+ EECDCG   EC+   CC  + C L+   +C  G CC  +C L  AG  CR+++  +
Sbjct: 425 VEAGEECDCGPGQECR-DLCCFAHNCSLRPGAQCAHGDCCV-RCLLKPAGALCRQAMG-D 481

Query: 458 CDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFAC 517
           CD  E+C GTSS+C PD Y L+G  C  G+ YC++G C T + QC +++G G+  AP AC
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541

Query: 518 FKEVNSLHERSENCG-FKNSQPLPCERKDVLCGKLAC-------VQPHKNANKSDAQSTV 569
           F+ VNS  +   NCG       LPC  +D LCGKL C       + PH         STV
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPH----MVPVDSTV 597

Query: 570 YSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTK 629
           +   Q+  C       S + D      V  GT CGP M                      
Sbjct: 598 HLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRM---------------------- 635

Query: 630 CKGKGICNNFGNCQCFPGHRPPDC-KFQFGSPGGSIDDGNFQ 670
                +CN+  NC C PG  PP C K  F   GGS+D G  Q
Sbjct: 636 -----VCNSNHNCHCAPGWAPPFCDKPGF---GGSMDSGPVQ 669


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  256 bits (654), Expect = 5e-68
 Identities = 181/641 (28%), Positives = 287/641 (44%), Gaps = 87/641 (13%)

Query: 44  KMIYIITIDGQPYTLHLGKQSFLPQNFLVYTYNET-GSLHSVSPYFMMHCHYQGYAAEFP 102
           ++ Y++   G  +TLHL K   L  +    TY    GS  +  P    HC YQG+   +P
Sbjct: 56  RVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYP 115

Query: 103 NSFVTLSICSGLRGFLQFENISYGIEPV-ESSARFEHIIYQMK-----------NNDPNV 150
           +S  +LS C+GLRGF Q  +  + IEP+ E      H +YQ +           ++D   
Sbjct: 116 DSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLG 175

Query: 151 SILAVNYSHIWQKDQPYKVPLNSQIKNLSKLLPQYLEIYIIVEKALYDYMGSEMMAVTQK 210
           S+L    + +++      +P             +Y+E+Y++V+ A +  +GSE  AV  +
Sbjct: 176 SLLGPRTAAVFRPRPGDSLPSRE---------TRYVELYVVVDNAEFQMLGSE-AAVRHR 225

Query: 211 IVQVIGLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWK-RDYLILRPH 269
           +++V+  V+ ++ +    V+L  LE+W+++++   S D    L+  L W+ R       H
Sbjct: 226 VLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLH 285

Query: 270 DIAYLLVYRKHPKYVGATFPGTVCN-------KSYDAGIAMYPDAIGLEGFSVIIAQLLG 322
           D   L+         G  F GT           S+ +G      +    G +  +A  +G
Sbjct: 286 DNVQLI--------TGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMG 337

Query: 323 LNVGLTYDDITQ-CFCLR----ATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCL 377
            N+G+ +D+  Q C C        CIM   ++ +S  ++FS+CS      F+ + ++ CL
Sbjct: 338 HNLGMDHDENVQGCRCQERFEAGRCIM-AGSIGSSFPRMFSDCSQAYLESFLERPQSVCL 396

Query: 378 QKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCC 437
               +L  L    PVCGN  +E  E+CDCG   +C+  +CC+  TC+L    +C  G CC
Sbjct: 397 ANAPDLSHL-VGGPVCGNLFVERGEQCDCGPPEDCR-NRCCNSTTCQLAEGAQCAHGTCC 454

Query: 438 TSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQT 497
             +C++  AG  CR   D  CD  E+C+G    C  D +  NG  C  G  YCYNG C T
Sbjct: 455 -QECKVKPAGELCRPKKD-MCDLEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPT 510

Query: 498 TDNQCAKIFGKGAQGAPFACFK-----EVNSLHERSENCGFKNSQPLPCERKDVLCGKLA 552
              QC   +G G Q A  +CF         +   R++ CG      L C+      G+  
Sbjct: 511 LAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGV-----LQCKGGQQPLGRAI 565

Query: 553 CVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNK 612
           C+                      VC ++ T      DGT    V +GT CGPE  C   
Sbjct: 566 CIV--------------------DVCHALTT-----EDGTAYEPVPEGTRCGPEKVCWKG 600

Query: 613 TCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDC 653
            C+ +H+   + N + +C   G+CN+   C C  G  PP C
Sbjct: 601 RCQDLHVY-RSSNCSAQCHNHGVCNHKQECHCHAGWAPPHC 640


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  247 bits (631), Expect = 2e-65
 Identities = 177/599 (29%), Positives = 273/599 (45%), Gaps = 55/599 (9%)

Query: 91  HCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVE-----SSARFEHIIY---- 141
           HC+Y G      +S V LS C+GL G  + +   Y IEP+E      S    HII     
Sbjct: 195 HCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLA 254

Query: 142 -----QMKNNDPNVSILAVNYSHI-WQKDQPYKVPLNSQIKNLSKLLPQYLEIYIIVEKA 195
                QMKN            S + W K +   V  +  I    K    YLE+ I+ +  
Sbjct: 255 GQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMK----YLELMIVNDHK 310

Query: 196 LYDYMGSEMMAVTQKIVQVIGLVNTMFT-QFKLTVILSSLELWSNENQISTSGDADDILQ 254
            Y    S           V+ LV++++  Q    V+L ++E W+ ++QI  + +   +L 
Sbjct: 311 TYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLH 370

Query: 255 RFLAWKRDYLILRPHDIAYLLVYRK--HPKYVGATFPGTVCNKSYDAGIAMY--PDAIGL 310
            F  +++    ++ H  A  L+ R   H K    ++ G VC+++   G+  Y  P A+  
Sbjct: 371 EFSKYRQR---IKQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAV-- 425

Query: 311 EGFSVIIAQLLGLNVGLTYDDITQ---CFCLRAT--CIMNHEAVSASGRKIFSNCSMHDY 365
              + +++Q L  N+G+ ++  ++   C C  +   CIM    VS S +  FS CS+ +Y
Sbjct: 426 ---AQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRK--FSKCSILEY 480

Query: 366 RYFVSKFETKCLQKLSNLQPLHQNQPV-CGNGILESNEECDCGNKNECQFKKCCDYNTCK 424
           R F+ +    CL      +P    +P  CGNG +E+ EECDCG   EC +  CC    C 
Sbjct: 481 RDFLQRGGGACLFN----RPTKLFEPTECGNGYVEAGEECDCGFHVEC-YGLCC--KKCS 533

Query: 425 LKGSVKCGSGPCCTS-KCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLC 483
           L     C  GPCC +  C     G  CR +++ ECD TEYC G S  C P+ +  +G  C
Sbjct: 534 LSNGAHCSDGPCCNNTSCLFQPRGYECRDAVN-ECDITEYCTGDSGQCPPNLHKQDGYAC 592

Query: 484 KLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCER 543
                 CYNG+C+T DNQC  I+G  A G+   C++++N+      NCG    + + C +
Sbjct: 593 NQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSK 652

Query: 544 KDVLCGKLACVQPHKNANKSDAQSTVY--SYIQDHVCVSIATGSSMRSDGTDNAYVADGT 601
            DV CG L C    +       Q  +   S+      +  +    +  D TD  YV DGT
Sbjct: 653 HDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVEDGT 712

Query: 602 MCGPEMYCVNKTCRKVHLMGY-NCNATTK---CKGKGICNNFGNCQCFPGHRPPDCKFQ 656
            CGP M C+++ C ++  +   +C   +K   C G G+C+N   C C       DC  +
Sbjct: 713 PCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR 771


>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
           sapiens]
          Length = 769

 Score =  246 bits (629), Expect = 4e-65
 Identities = 173/603 (28%), Positives = 271/603 (44%), Gaps = 65/603 (10%)

Query: 91  HCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSARF-------EHIIYQM 143
           HC+YQG     P+SF  LS C GL G     N++Y +EP E +  +        H+IY+ 
Sbjct: 132 HCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRT 191

Query: 144 KNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLL---------------PQYLEI 188
                    L  +     +    + VP  S   N  +L                 +Y+E+
Sbjct: 192 P--------LLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVEL 243

Query: 189 YIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFT-QFKLTVILSSLELWSNENQISTSG 247
            +I +  L++ M   ++  +     V+ L + ++  Q    ++L ++E W++ ++I    
Sbjct: 244 IVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQD 303

Query: 248 DADDILQRFLAWKRDYLILRPHDIAYLLVYRKHPKYV-GATFPGTVCNKSYDAGIAMYPD 306
           D  + L R + ++R+ L   P D  +L   R       GA + G +C+ S+  G+  Y +
Sbjct: 304 DLLETLARLMVYRREGLP-EPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGN 362

Query: 307 AIGLEGFSVIIAQLLGLNVGLTYD----DITQCFC--LRATCIMNHEAVSASGRKIFSNC 360
              +   +V +AQ LG N+G+ ++        C C  +   CIM         +  FS C
Sbjct: 363 ---MGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRK--FSRC 417

Query: 361 SMHDYRYFVSKFETKCL--QKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFK--K 416
           S+ +Y  F+ +    CL  + L  L P     P CGNG +E+ EECDCG+  EC      
Sbjct: 418 SIDEYNQFLQEGGGSCLFNKPLKLLDP-----PECGNGFVEAGEECDCGSVQECSRAGGN 472

Query: 417 CCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTY 476
           CC    C L     C  G CC  +C+    G  CR++++ ECD  E C G SS C P+ +
Sbjct: 473 CC--KKCTLTHDAMCSDGLCCR-RCKYEPRGVSCREAVN-ECDIAETCTGDSSQCPPNLH 528

Query: 477 ALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNS 536
            L+G  C      CY G+C+T D QC  ++G  A  A   C++++N       +CG K S
Sbjct: 529 KLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGS 586

Query: 537 QPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVC--VSIATGSSMRSDGTDN 594
             + C ++DVLCG L CV         D    + S    H    +    G    +DG+D 
Sbjct: 587 GWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDL 646

Query: 595 AYVADGTMCGPEMYCVNKTCRKVHLMGYN-CNATTK---CKGKGICNNFGNCQCFPGHRP 650
           +YV DGT CGP M C++  C       ++ C  + +   C   G+C+N G C C P    
Sbjct: 647 SYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTG 706

Query: 651 PDC 653
            DC
Sbjct: 707 KDC 709


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  239 bits (611), Expect = 5e-63
 Identities = 161/597 (26%), Positives = 272/597 (45%), Gaps = 45/597 (7%)

Query: 91  HCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFE----HIIYQMKNN 146
           HC+YQG+    P+SFV LS C GL G     N +Y IEP E+    E    H +Y+ +  
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLF 193

Query: 147 DPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLL----------PQYLEIYIIVEKAL 196
           + ++  L   +  +     P K  L  + K   + L           +Y+E+ I+ +  +
Sbjct: 194 EFSLDDLPSEFQQV--NITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLM 251

Query: 197 YDYMGSEMMAVTQKIVQVIGLVNTMFT-QFKLTVILSSLELWSNENQISTSGDADDILQR 255
           +      ++        V+ + + ++  Q K  ++L ++E W+ +N+ + S +    L+ 
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 256 FLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSV 315
           F+ ++RD++  +   +      +      GA + G +C+     G+  +      +  +V
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 316 IIAQLLGLNVGLTYDDIT----QCFC--LRATCIMNHEAVSASGRKIFSNCSMHDYRYFV 369
            +AQ L  N+G+  D       +C C    + CIM          K F+ C++ +Y  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 370 SKFETKCL-QKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFK--KCCDYNTCKLK 426
           +     CL  K S L     + P CGNG +E+ EECDCG   EC  +  +CC    C L 
Sbjct: 427 NSGGGACLFNKPSKLL----DPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLT 480

Query: 427 GSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLG 486
              +C  G CC  KC+    GT CR++++ +CD  E C+G SS C P+ + ++G  C   
Sbjct: 481 QDSQCSDGLCC-KKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 487 TAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDV 546
              C+ G+C+T D QC  I+G+    +   C++++N       NCG      + C ++DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 547 LCGKLAC--VQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCG 604
           LCG L C  +       + D + T    +Q    ++ + G     +  D  YV DGT CG
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCG 658

Query: 605 PEMYCVNKTCRKVHLMGYNCNATTK----CKGKGICNNFGNCQCFPGHRPPDCKFQF 657
           P+M C+   C  V    ++   ++K    C G G+C+N   C C       DC   F
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  239 bits (611), Expect = 5e-63
 Identities = 161/597 (26%), Positives = 272/597 (45%), Gaps = 45/597 (7%)

Query: 91  HCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFE----HIIYQMKNN 146
           HC+YQG+    P+SFV LS C GL G     N +Y IEP E+    E    H +Y+ +  
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLF 193

Query: 147 DPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLL----------PQYLEIYIIVEKAL 196
           + ++  L   +  +     P K  L  + K   + L           +Y+E+ I+ +  +
Sbjct: 194 EFSLDDLPSEFQQV--NITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLM 251

Query: 197 YDYMGSEMMAVTQKIVQVIGLVNTMFT-QFKLTVILSSLELWSNENQISTSGDADDILQR 255
           +      ++        V+ + + ++  Q K  ++L ++E W+ +N+ + S +    L+ 
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 256 FLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSV 315
           F+ ++RD++  +   +      +      GA + G +C+     G+  +      +  +V
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 316 IIAQLLGLNVGLTYDDIT----QCFC--LRATCIMNHEAVSASGRKIFSNCSMHDYRYFV 369
            +AQ L  N+G+  D       +C C    + CIM          K F+ C++ +Y  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 370 SKFETKCL-QKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFK--KCCDYNTCKLK 426
           +     CL  K S L     + P CGNG +E+ EECDCG   EC  +  +CC    C L 
Sbjct: 427 NSGGGACLFNKPSKLL----DPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLT 480

Query: 427 GSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLG 486
              +C  G CC  KC+    GT CR++++ +CD  E C+G SS C P+ + ++G  C   
Sbjct: 481 QDSQCSDGLCC-KKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 487 TAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDV 546
              C+ G+C+T D QC  I+G+    +   C++++N       NCG      + C ++DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 547 LCGKLAC--VQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCG 604
           LCG L C  +       + D + T    +Q    ++ + G     +  D  YV DGT CG
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCG 658

Query: 605 PEMYCVNKTCRKVHLMGYNCNATTK----CKGKGICNNFGNCQCFPGHRPPDCKFQF 657
           P+M C+   C  V    ++   ++K    C G G+C+N   C C       DC   F
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  239 bits (611), Expect = 5e-63
 Identities = 161/597 (26%), Positives = 272/597 (45%), Gaps = 45/597 (7%)

Query: 91  HCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFE----HIIYQMKNN 146
           HC+YQG+    P+SFV LS C GL G     N +Y IEP E+    E    H +Y+ +  
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLF 193

Query: 147 DPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLL----------PQYLEIYIIVEKAL 196
           + ++  L   +  +     P K  L  + K   + L           +Y+E+ I+ +  +
Sbjct: 194 EFSLDDLPSEFQQV--NITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLM 251

Query: 197 YDYMGSEMMAVTQKIVQVIGLVNTMFT-QFKLTVILSSLELWSNENQISTSGDADDILQR 255
           +      ++        V+ + + ++  Q K  ++L ++E W+ +N+ + S +    L+ 
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 256 FLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSV 315
           F+ ++RD++  +   +      +      GA + G +C+     G+  +      +  +V
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 316 IIAQLLGLNVGLTYDDIT----QCFC--LRATCIMNHEAVSASGRKIFSNCSMHDYRYFV 369
            +AQ L  N+G+  D       +C C    + CIM          K F+ C++ +Y  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 370 SKFETKCL-QKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFK--KCCDYNTCKLK 426
           +     CL  K S L     + P CGNG +E+ EECDCG   EC  +  +CC    C L 
Sbjct: 427 NSGGGACLFNKPSKLL----DPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLT 480

Query: 427 GSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLG 486
              +C  G CC  KC+    GT CR++++ +CD  E C+G SS C P+ + ++G  C   
Sbjct: 481 QDSQCSDGLCC-KKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 487 TAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDV 546
              C+ G+C+T D QC  I+G+    +   C++++N       NCG      + C ++DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 547 LCGKLAC--VQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCG 604
           LCG L C  +       + D + T    +Q    ++ + G     +  D  YV DGT CG
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCG 658

Query: 605 PEMYCVNKTCRKVHLMGYNCNATTK----CKGKGICNNFGNCQCFPGHRPPDCKFQF 657
           P+M C+   C  V    ++   ++K    C G G+C+N   C C       DC   F
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  239 bits (611), Expect = 5e-63
 Identities = 161/597 (26%), Positives = 272/597 (45%), Gaps = 45/597 (7%)

Query: 91  HCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFE----HIIYQMKNN 146
           HC+YQG+    P+SFV LS C GL G     N +Y IEP E+    E    H +Y+ +  
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLF 193

Query: 147 DPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLL----------PQYLEIYIIVEKAL 196
           + ++  L   +  +     P K  L  + K   + L           +Y+E+ I+ +  +
Sbjct: 194 EFSLDDLPSEFQQV--NITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLM 251

Query: 197 YDYMGSEMMAVTQKIVQVIGLVNTMFT-QFKLTVILSSLELWSNENQISTSGDADDILQR 255
           +      ++        V+ + + ++  Q K  ++L ++E W+ +N+ + S +    L+ 
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 256 FLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSV 315
           F+ ++RD++  +   +      +      GA + G +C+     G+  +      +  +V
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 316 IIAQLLGLNVGLTYDDIT----QCFC--LRATCIMNHEAVSASGRKIFSNCSMHDYRYFV 369
            +AQ L  N+G+  D       +C C    + CIM          K F+ C++ +Y  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 370 SKFETKCL-QKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFK--KCCDYNTCKLK 426
           +     CL  K S L     + P CGNG +E+ EECDCG   EC  +  +CC    C L 
Sbjct: 427 NSGGGACLFNKPSKLL----DPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLT 480

Query: 427 GSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLG 486
              +C  G CC  KC+    GT CR++++ +CD  E C+G SS C P+ + ++G  C   
Sbjct: 481 QDSQCSDGLCC-KKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 487 TAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDV 546
              C+ G+C+T D QC  I+G+    +   C++++N       NCG      + C ++DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 547 LCGKLAC--VQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCG 604
           LCG L C  +       + D + T    +Q    ++ + G     +  D  YV DGT CG
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCG 658

Query: 605 PEMYCVNKTCRKVHLMGYNCNATTK----CKGKGICNNFGNCQCFPGHRPPDCKFQF 657
           P+M C+   C  V    ++   ++K    C G G+C+N   C C       DC   F
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score =  239 bits (611), Expect = 5e-63
 Identities = 161/597 (26%), Positives = 272/597 (45%), Gaps = 45/597 (7%)

Query: 91  HCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFE----HIIYQMKNN 146
           HC+YQG+    P+SFV LS C GL G     N +Y IEP E+    E    H +Y+ +  
Sbjct: 134 HCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLF 193

Query: 147 DPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLL----------PQYLEIYIIVEKAL 196
           + ++  L   +  +     P K  L  + K   + L           +Y+E+ I+ +  +
Sbjct: 194 EFSLDDLPSEFQQV--NITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLM 251

Query: 197 YDYMGSEMMAVTQKIVQVIGLVNTMFT-QFKLTVILSSLELWSNENQISTSGDADDILQR 255
           +      ++        V+ + + ++  Q K  ++L ++E W+ +N+ + S +    L+ 
Sbjct: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311

Query: 256 FLAWKRDYLILRPHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSV 315
           F+ ++RD++  +   +      +      GA + G +C+     G+  +      +  +V
Sbjct: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368

Query: 316 IIAQLLGLNVGLTYDDIT----QCFC--LRATCIMNHEAVSASGRKIFSNCSMHDYRYFV 369
            +AQ L  N+G+  D       +C C    + CIM          K F+ C++ +Y  F+
Sbjct: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426

Query: 370 SKFETKCL-QKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFK--KCCDYNTCKLK 426
           +     CL  K S L     + P CGNG +E+ EECDCG   EC  +  +CC    C L 
Sbjct: 427 NSGGGACLFNKPSKLL----DPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLT 480

Query: 427 GSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLG 486
              +C  G CC  KC+    GT CR++++ +CD  E C+G SS C P+ + ++G  C   
Sbjct: 481 QDSQCSDGLCC-KKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538

Query: 487 TAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDV 546
              C+ G+C+T D QC  I+G+    +   C++++N       NCG      + C ++DV
Sbjct: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598

Query: 547 LCGKLAC--VQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCG 604
           LCG L C  +       + D + T    +Q    ++ + G     +  D  YV DGT CG
Sbjct: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCG 658

Query: 605 PEMYCVNKTCRKVHLMGYNCNATTK----CKGKGICNNFGNCQCFPGHRPPDCKFQF 657
           P+M C+   C  V    ++   ++K    C G G+C+N   C C       DC   F
Sbjct: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715


>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
           [Homo sapiens]
          Length = 540

 Score =  232 bits (592), Expect = 8e-61
 Identities = 159/527 (30%), Positives = 255/527 (48%), Gaps = 25/527 (4%)

Query: 5   LALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDS-EVSERKMIYIITIDGQPYTLHLGK- 62
           ++ + EL  ++ +E    I LH    R+ K  +  E  E ++ Y +TI+G+   L+L K 
Sbjct: 16  VSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKN 75

Query: 63  QSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQFEN 122
           ++ L   +    YN TG   + SP  M  C+YQG+      S  ++S C GLRG+    +
Sbjct: 76  KNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRGYFSQGD 135

Query: 123 ISYGIEPVESSARF--EHIIYQMKNNDPNVSILAVNYSHIWQKD--QPYKVPLNSQIKNL 178
             Y IEP+    R   EH +++   ++ N          +W  D  Q   +P    +K  
Sbjct: 136 QRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQNIALPATKLVKLK 195

Query: 179 SKLLPQ---YLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLE 235
            + + +   Y+E Y++++   +         + +++ ++   VN ++ +    V L  +E
Sbjct: 196 DRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGME 255

Query: 236 LWSNENQISTSGDADDILQRFLAWKRDYLILRP-HDIAYLLVYRKHP-KYVGATFPGTVC 293
           +W+++++I  + +A   L+ F  W+   L  R  HDIA L+   +     VG  F  T+C
Sbjct: 256 IWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMC 315

Query: 294 NKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMNHEAVSASG 353
           +  Y  G+     +  L   +  +A  +G N G+ +DD + C C    C+M+ +A+S   
Sbjct: 316 SP-YSVGVVQ-DHSDNLLRVAGTMAHEMGHNFGMFHDDYS-CKCPSTICVMD-KALSFYI 371

Query: 354 RKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQN---QPVCGNGILESNEECDCGNKN 410
              FS+CS   Y  F   FE K    L N  PL  +    P+CGN ++E  E+CDCG   
Sbjct: 372 PTDFSSCSRLSYDKF---FEDKLSNCLFNA-PLPTDIISTPICGNQLVEMGEDCDCGTSE 427

Query: 411 ECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSN 470
           EC    CCD  TCK+K + +C  G CC  KC+   AG  CR + D ECD  E CNG S N
Sbjct: 428 ECT-NICCDAKTCKIKATFQCALGECC-EKCQFKKAGMVCRPAKD-ECDLPEMCNGKSGN 484

Query: 471 CVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFAC 517
           C  D + +NG  C  G  +C  G C T   QC +++G G +  PF C
Sbjct: 485 CPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPC 531


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  228 bits (581), Expect = 2e-59
 Identities = 173/629 (27%), Positives = 287/629 (45%), Gaps = 35/629 (5%)

Query: 49  ITIDGQPYTLHL-GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVT 107
           + +DG  + L L   +  +P    +  Y   G+      + + +C YQG    +  S+V+
Sbjct: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132

Query: 108 LSICSGLRGFLQFE-NISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQP 166
           +  CSGLRG +      SY +E      +   II ++++        A+++       +P
Sbjct: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKP 192

Query: 167 YKVPLNSQ-IKNLSKLLPQYLEIYIIVEKALYDYMGSE----MMAVTQKIVQVIGLVNTM 221
            + PL  + I+    ++ +   + +++   + D+  ++       +  + ++V  L++T 
Sbjct: 193 PEHPLGQRHIRRRRDVVTETKTVELVI---VADHSEAQKYRDFQHLLNRTLEVALLLDTF 249

Query: 222 FTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYLLVYRKH 280
           F    + V L  LE W+  + +  S +    L+ FL W+R +L+ R PHD A L+     
Sbjct: 250 FRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSF 309

Query: 281 P-KYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYD-DITQCFCL 338
               VG     ++C+  +  G+ M   +  + G +  IA  LG ++GL +D     C C 
Sbjct: 310 SGPTVGMAIQNSICSPDFSGGVNM-DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368

Query: 339 ----RATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCL-QKLSNLQPLHQNQPVC 393
                 TCIM        G   FSNCS       +      CL ++L +L P+      C
Sbjct: 369 GPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKALLDGMGSCLFERLPSLPPM---AAFC 424

Query: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGS-GPCCTSKCELSIAGTPCRK 452
           GN  +E  E+CDCG  ++C    CCD  TC+L+   +C S GPCC + C+L  +G  CR 
Sbjct: 425 GNMFVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQN-CQLRPSGWQCRP 482

Query: 453 SIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQG 512
           +   +CD  E+C G SS C PD    +G  C  G A C +G+C +   QC  ++G GAQ 
Sbjct: 483 TRG-DCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQP 541

Query: 513 APFACFKEVNSLHERSENCGFKNS-QPLPCERKDVLCGKLAC----VQPHKNANKSDAQS 567
           A   C +  N+      +CG   S   + C  +D +CG+L C     QP   + +     
Sbjct: 542 AAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWE 601

Query: 568 TVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNAT 627
           T+     +  C  +     + SD         GT CGP + C++  C++V L+G      
Sbjct: 602 TIDVNGTELNCSWVHL--DLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECR 658

Query: 628 TKCKGKGICNNFGNCQCFPGHRPPDCKFQ 656
           +KC G G+C++  +C C  G  PPDC  Q
Sbjct: 659 SKCHGHGVCDSNRHCYCEEGWAPPDCTTQ 687


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  228 bits (581), Expect = 2e-59
 Identities = 173/629 (27%), Positives = 287/629 (45%), Gaps = 35/629 (5%)

Query: 49  ITIDGQPYTLHL-GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVT 107
           + +DG  + L L   +  +P    +  Y   G+      + + +C YQG    +  S+V+
Sbjct: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132

Query: 108 LSICSGLRGFLQFE-NISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQP 166
           +  CSGLRG +      SY +E      +   II ++++        A+++       +P
Sbjct: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKP 192

Query: 167 YKVPLNSQ-IKNLSKLLPQYLEIYIIVEKALYDYMGSE----MMAVTQKIVQVIGLVNTM 221
            + PL  + I+    ++ +   + +++   + D+  ++       +  + ++V  L++T 
Sbjct: 193 PEHPLGQRHIRRRRDVVTETKTVELVI---VADHSEAQKYRDFQHLLNRTLEVALLLDTF 249

Query: 222 FTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYLLVYRKH 280
           F    + V L  LE W+  + +  S +    L+ FL W+R +L+ R PHD A L+     
Sbjct: 250 FRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSF 309

Query: 281 P-KYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYD-DITQCFCL 338
               VG     ++C+  +  G+ M   +  + G +  IA  LG ++GL +D     C C 
Sbjct: 310 SGPTVGMAIQNSICSPDFSGGVNM-DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368

Query: 339 ----RATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCL-QKLSNLQPLHQNQPVC 393
                 TCIM        G   FSNCS       +      CL ++L +L P+      C
Sbjct: 369 GPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKALLDGMGSCLFERLPSLPPM---AAFC 424

Query: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGS-GPCCTSKCELSIAGTPCRK 452
           GN  +E  E+CDCG  ++C    CCD  TC+L+   +C S GPCC + C+L  +G  CR 
Sbjct: 425 GNMFVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQN-CQLRPSGWQCRP 482

Query: 453 SIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQG 512
           +   +CD  E+C G SS C PD    +G  C  G A C +G+C +   QC  ++G GAQ 
Sbjct: 483 TRG-DCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQP 541

Query: 513 APFACFKEVNSLHERSENCGFKNS-QPLPCERKDVLCGKLAC----VQPHKNANKSDAQS 567
           A   C +  N+      +CG   S   + C  +D +CG+L C     QP   + +     
Sbjct: 542 AAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWE 601

Query: 568 TVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNAT 627
           T+     +  C  +     + SD         GT CGP + C++  C++V L+G      
Sbjct: 602 TIDVNGTELNCSWVHL--DLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECR 658

Query: 628 TKCKGKGICNNFGNCQCFPGHRPPDCKFQ 656
           +KC G G+C++  +C C  G  PPDC  Q
Sbjct: 659 SKCHGHGVCDSNRHCYCEEGWAPPDCTTQ 687


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  228 bits (581), Expect = 2e-59
 Identities = 173/629 (27%), Positives = 287/629 (45%), Gaps = 35/629 (5%)

Query: 49  ITIDGQPYTLHL-GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVT 107
           + +DG  + L L   +  +P    +  Y   G+      + + +C YQG    +  S+V+
Sbjct: 73  LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132

Query: 108 LSICSGLRGFLQFE-NISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQP 166
           +  CSGLRG +      SY +E      +   II ++++        A+++       +P
Sbjct: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKP 192

Query: 167 YKVPLNSQ-IKNLSKLLPQYLEIYIIVEKALYDYMGSE----MMAVTQKIVQVIGLVNTM 221
            + PL  + I+    ++ +   + +++   + D+  ++       +  + ++V  L++T 
Sbjct: 193 PEHPLGQRHIRRRRDVVTETKTVELVI---VADHSEAQKYRDFQHLLNRTLEVALLLDTF 249

Query: 222 FTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILR-PHDIAYLLVYRKH 280
           F    + V L  LE W+  + +  S +    L+ FL W+R +L+ R PHD A L+     
Sbjct: 250 FRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSF 309

Query: 281 P-KYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYD-DITQCFCL 338
               VG     ++C+  +  G+ M   +  + G +  IA  LG ++GL +D     C C 
Sbjct: 310 SGPTVGMAIQNSICSPDFSGGVNM-DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368

Query: 339 ----RATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCL-QKLSNLQPLHQNQPVC 393
                 TCIM        G   FSNCS       +      CL ++L +L P+      C
Sbjct: 369 GPAPAKTCIMEASTDFLPGLN-FSNCSRRALEKALLDGMGSCLFERLPSLPPM---AAFC 424

Query: 394 GNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGS-GPCCTSKCELSIAGTPCRK 452
           GN  +E  E+CDCG  ++C    CCD  TC+L+   +C S GPCC + C+L  +G  CR 
Sbjct: 425 GNMFVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQN-CQLRPSGWQCRP 482

Query: 453 SIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQG 512
           +   +CD  E+C G SS C PD    +G  C  G A C +G+C +   QC  ++G GAQ 
Sbjct: 483 TRG-DCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQP 541

Query: 513 APFACFKEVNSLHERSENCGFKNS-QPLPCERKDVLCGKLAC----VQPHKNANKSDAQS 567
           A   C +  N+      +CG   S   + C  +D +CG+L C     QP   + +     
Sbjct: 542 AAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWE 601

Query: 568 TVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNAT 627
           T+     +  C  +     + SD         GT CGP + C++  C++V L+G      
Sbjct: 602 TIDVNGTELNCSWVHL--DLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECR 658

Query: 628 TKCKGKGICNNFGNCQCFPGHRPPDCKFQ 656
           +KC G G+C++  +C C  G  PPDC  Q
Sbjct: 659 SKCHGHGVCDSNRHCYCEEGWAPPDCTTQ 687


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,789,006
Number of Sequences: 37866
Number of extensions: 1443819
Number of successful extensions: 3736
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 2955
Number of HSP's gapped (non-prelim): 557
length of query: 739
length of database: 18,247,518
effective HSP length: 110
effective length of query: 629
effective length of database: 14,082,258
effective search space: 8857740282
effective search space used: 8857740282
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.