Search of human proteins with 73747885

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|73747885 ADAM metallopeptidase domain 12 isoform 1
preproprotein [Homo sapiens]
         (909 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...  1913   0.0  
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...  1489   0.0  
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   754   0.0  
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   620   e-177
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   593   e-169
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   544   e-154
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   543   e-154
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   532   e-151
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   530   e-150
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   524   e-148
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   522   e-148
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   520   e-147
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...   512   e-145
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   430   e-120
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   387   e-107
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   372   e-102
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...   372   e-102
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   371   e-102
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   371   e-102
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   371   e-102
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   368   e-101
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   363   e-100
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   363   e-100
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   363   e-100
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   363   e-100
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   354   2e-97
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...   354   2e-97
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot...   351   2e-96
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...   350   4e-96
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s...   340   4e-93

>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score = 1913 bits (4955), Expect = 0.0
 Identities = 909/909 (100%), Positives = 909/909 (100%)

Query: 1   MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD 60
           MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD
Sbjct: 1   MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD 60

Query: 61  SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY 120
           SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY
Sbjct: 61  SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY 120

Query: 121 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG 180
           YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG
Sbjct: 121 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG 180

Query: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
           SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR
Sbjct: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240

Query: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
           LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH
Sbjct: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300

Query: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
           DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH
Sbjct: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360

Query: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
           DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE
Sbjct: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420

Query: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
           SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT
Sbjct: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480

Query: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
           ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG
Sbjct: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540

Query: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
           AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS
Sbjct: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600

Query: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC 660
           IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC
Sbjct: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC 660

Query: 661 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCL 720
           AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCL
Sbjct: 661 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCL 720

Query: 721 LAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPP 780
           LAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPP
Sbjct: 721 LAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPP 780

Query: 781 DSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKP 840
           DSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKP
Sbjct: 781 DSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKP 840

Query: 841 ALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVP 900
           ALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVP
Sbjct: 841 ALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVP 900

Query: 901 RSTHTAYIK 909
           RSTHTAYIK
Sbjct: 901 RSTHTAYIK 909


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score = 1489 bits (3856), Expect = 0.0
 Identities = 704/705 (99%), Positives = 705/705 (100%)

Query: 1   MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD 60
           MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD
Sbjct: 1   MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD 60

Query: 61  SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY 120
           SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY
Sbjct: 61  SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY 120

Query: 121 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG 180
           YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG
Sbjct: 121 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG 180

Query: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
           SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR
Sbjct: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240

Query: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
           LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH
Sbjct: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300

Query: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
           DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH
Sbjct: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360

Query: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
           DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE
Sbjct: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420

Query: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
           SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT
Sbjct: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480

Query: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
           ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG
Sbjct: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540

Query: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
           AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS
Sbjct: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600

Query: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC 660
           IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC
Sbjct: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC 660

Query: 661 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAD 705
           AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQA+
Sbjct: 661 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAE 705


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  754 bits (1947), Expect = 0.0
 Identities = 410/916 (44%), Positives = 539/916 (58%), Gaps = 60/916 (6%)

Query: 11  ARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDL--------WIPVKSFDSK 62
           AR  LLA A   L P  AR    W +G  +       GS  L        W   +S   +
Sbjct: 8   ARLCLLAFALQPLRPRAAREPG-WTRGSEE-------GSPKLQHELIIPQWKTSESPVRE 59

Query: 63  NHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYH 122
            HP    +R+  E +ELI++LE+NE L A S+TETHY   G   +  R    +  HC+YH
Sbjct: 60  KHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRK---LEDHCFYH 116

Query: 123 GHVRGYSDSAVSLSTCSGLRGLI-VFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGS 181
           G VR    S+V+LSTC G+RGLI V  N SYV+EP+  +  ++ ++ ++ LK   G+CG 
Sbjct: 117 GTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGF 176

Query: 182 HHNTPNLAAKNV-FPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
            H+ P      + F   ++   RR KRE L + KYVEL +VAD  EFQ+  +D +  K +
Sbjct: 177 EHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHK 236

Query: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
           LIEIAN+VDKFYR LNIRI LVG+EVW   + C VS++P+++L  FL WR+ KLL +K H
Sbjct: 237 LIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRR-KLLAQKYH 295

Query: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
           DNAQL++G+ F GTTIG+AP+M+MC+  QSGG+ MDHS+N +G A T+AHE+GHNFGM H
Sbjct: 296 DNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTH 355

Query: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
           D+ D    C  +   GGCIM A+TG+PFP VF+ C+R++L+  L+ G G+CL N+P+ R 
Sbjct: 356 DSAD---CCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRM 412

Query: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
            +GG++CGN ++E+GEECDCGE EEC N CCNA+ CTL+P A CAHG CC  C+L   GT
Sbjct: 413 LYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGT 472

Query: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
            CR+ +  CDLPEFCTG SPHCP N Y  DG  C+    YCYNG+C T+++QC  LWGPG
Sbjct: 473 LCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPG 532

Query: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
           A+PAP +CFE+VN AGD +GNCGK       KC MRDAKCGKIQCQ   +RP + +NAV 
Sbjct: 533 ARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARP-LESNAVP 591

Query: 601 IETNIPLQQGGRILCRGTHVYLG----DDMPDPGLVLAGTKCADGKICLNRQCQNISVFG 656
           I+T I +  G +I CRGTHVY G     DM DPGLV+ GTKC    IC   QC+N S F 
Sbjct: 592 IDTTI-IMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFE 650

Query: 657 VHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVT 716
              C  +C+G GVCNN +NCHC   WAPPFC+  G GGS DSGP+       +  G+LV 
Sbjct: 651 TEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVA 710

Query: 717 ILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLM 776
           IL L     + Y  R+     L   K + +      + S P R  Q   +  GH      
Sbjct: 711 ILVLAVLMLMYYCCRQN--NKLGQLKPSALPSKLRQQFSCPFRVSQ--NSGTGHANPTFK 766

Query: 777 RKPPDSYPPKDNPRRLLQCQNVDISRP----LNGLNVPQP------QSTQRVLPPLHRAP 826
            + P       N   +L+  +    RP    L G + P P      ++ +    P  +  
Sbjct: 767 LQTPQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIE 826

Query: 827 RAPS----VPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWET 882
           R  S     P+RP+P  P    +Q   +P PPQK LPA+P+     L       PG    
Sbjct: 827 RTESSRRPPPSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPR-----PG---- 877

Query: 883 GLRLAPLRPAPQYPHQ 898
               +PLRP    P Q
Sbjct: 878 --GASPLRPPGAGPQQ 891


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  620 bits (1600), Expect = e-177
 Identities = 352/867 (40%), Positives = 470/867 (54%), Gaps = 93/867 (10%)

Query: 14  LLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQ 73
           LLL L   LL P    GV L        V    V  G  W  V   +  + P++  + L+
Sbjct: 13  LLLLLLLLLLWPVPGAGV-LQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALE 71

Query: 74  RESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAV 133
            E +EL++ LE+N  L+A  + ETHY  DG  V LA N+T    HC+Y G VRG+ DS V
Sbjct: 72  AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT---DHCHYQGRVRGFPDSWV 128

Query: 134 SLSTCSGLRGLIVFE-NESYVLEPMKSATNR----YKLFPAKKLKSVRGSCGSHHNTPNL 188
            L TCSG+ GLI    N SY L P     ++    +++F  ++L + +G+CG H +  N 
Sbjct: 129 VLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG-HRDPGNK 187

Query: 189 AAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
           A     P   Q+  RR  R T    KY+EL IVAD+  F  + ++L   KQRL+E+AN+V
Sbjct: 188 AGMTSLPGGPQSRGRREARRT---RKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244

Query: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
           D+  R L+I++ L G+EVW + D+  V+QD   +L  FL WR+  L  ++ HD+AQL++G
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRR-GLWAQRPHDSAQLLTG 303

Query: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
             FQG T+G+AP+  MC A+ SGG+  DHS+ P+GAA T+AHE+GH+ G++HD    GC 
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP--DGCC 361

Query: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCG 428
            + A E GGC+M A+TG+PFP VFS+CSR+ L     KG G CL N P+         CG
Sbjct: 362 VEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCG 421

Query: 429 NRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNS 488
           N FVE GEECDCG  +EC + CC A  C+L+P A CAHG CC  C LKPAG  CR +   
Sbjct: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481

Query: 489 CDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGIC 548
           CDLPEFCTG S HCP +VYL DG  C    GYC++G C T EQQC  LWGPG+ PAP  C
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541

Query: 549 FERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQ 608
           F+ VNSAGD +GNCG+ S+  F  C  RDA CGK+QCQGG    ++  + V +++ + L 
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGG-KPSLLAPHMVPVDSTVHL- 599

Query: 609 QGGRILCRGTHVYLGD--DMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHG 666
            G  + CRG         D+   GLV  GT+C    +C +R+C+  +   +  C   CH 
Sbjct: 600 DGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHS 659

Query: 667 RGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFV 726
            GVCN+  NCHC   WAPPFCDK GFGGS DSGP++  ++    + +L+++L        
Sbjct: 660 HGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLL------- 712

Query: 727 VYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPC-----QAHLGHLGKGLMRKPPD 781
                                      P  P  G   C      AHL     G  R P  
Sbjct: 713 ---------------------------PLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPAC 745

Query: 782 SYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPA 841
           S  PKD P R           PL G               +H     P+   +P P  P 
Sbjct: 746 S-GPKDGPHR---------DHPLGG---------------VHPMELGPTATGQPWPLDP- 779

Query: 842 LRQAQGTCKPNP-PQKPLPA---DPLA 864
               + + +P+  P+KPLPA   DP A
Sbjct: 780 ----ENSHEPSSHPEKPLPAVSPDPQA 802


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  593 bits (1529), Expect = e-169
 Identities = 347/865 (40%), Positives = 459/865 (53%), Gaps = 115/865 (13%)

Query: 14  LLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQ 73
           LLL L   LL P    GV L        V    V  G  W  V   +  + P++  + L+
Sbjct: 13  LLLLLLLLLLWPVPGAGV-LQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALE 71

Query: 74  RESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAV 133
            E +EL++ LE+N  L+A  + ETHY  DG  V LA N+T    HC+Y G VRG+ DS V
Sbjct: 72  AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT---DHCHYQGRVRGFPDSWV 128

Query: 134 SLSTCSGLRGLIVFE-NESYVLEPMKSATNR----YKLFPAKKLKSVRGSCGSHHNTPNL 188
            L TCSG+ GLI    N SY L P     ++    +++F  ++L + +G+CG H +  N 
Sbjct: 129 VLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG-HRDPGNK 187

Query: 189 AAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
           A     P   Q+  RR  R T    KY+EL IVAD+  F  + ++L   KQRL+E+AN+V
Sbjct: 188 AGMTSLPGGPQSRGRREARRT---RKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244

Query: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
           D+  R L+I++ L G+EVW + D+  V+QD   +L  FL WR+  L  ++ HD+AQL++G
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRR-GLWAQRPHDSAQLLTG 303

Query: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
             FQG T+G+AP+  MC A+ SGG+  DHS+ P+GAA T+AHE+GH+ G++HD    GC 
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP--DGCC 361

Query: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCG 428
            + A E GGC+M A+TG+PFP VFS+CSR+ L     KG G CL N P+         CG
Sbjct: 362 VEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCG 421

Query: 429 NRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNS 488
           N FVE GEECDCG  +EC + CC A  C+L+P A CAHG CC  C LKPAG  CR +   
Sbjct: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481

Query: 489 CDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGIC 548
           CDLPEFCTG S HCP +VYL DG  C    GYC++G C T EQQC  LWGPG+ PAP  C
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541

Query: 549 FERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQ 608
           F+ VNSAGD +GNCG+ S+  F  C  RDA CGK+QCQGG    ++  + V +++ + L 
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGG-KPSLLAPHMVPVDSTVHL- 599

Query: 609 QGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRG 668
            G  + CRG        +P   L L G                    G+ E   QC  R 
Sbjct: 600 DGQEVTCRGALA-----LPSAQLDLLG-------------------LGLVEPGTQCGPRM 635

Query: 669 VCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVY 728
           VCN+  NCHC   WAPPFCDK GFGGS DSGP++  ++    + +L+++L          
Sbjct: 636 VCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLL--------- 686

Query: 729 LKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPC-----QAHLGHLGKGLMRKPPDSY 783
                                    P  P  G   C      AHL     G  R P  S 
Sbjct: 687 -------------------------PLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACS- 720

Query: 784 PPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALR 843
            PKD P R           PL G               +H     P+   +P P  P   
Sbjct: 721 GPKDGPHR---------DHPLGG---------------VHPMELGPTATGQPWPLDP--- 753

Query: 844 QAQGTCKPNP-PQKPLPA---DPLA 864
             + + +P+  P+KPLPA   DP A
Sbjct: 754 --ENSHEPSSHPEKPLPAVSPDPQA 776


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  544 bits (1401), Expect = e-154
 Identities = 331/874 (37%), Positives = 460/874 (52%), Gaps = 77/874 (8%)

Query: 41  EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
           E +   V   DL I +K     + PE L I+L+ +    I+ L +N  L+    T   Y 
Sbjct: 42  EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101

Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
            DGT V ++  +T  L +C Y G VRGY+ S VS+ TCSGLRGL+V   E SY LE    
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158

Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
                 +    +   + G +C           K    PP     +RH   +R+ +  TK 
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214

Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
           VELVIVAD+ E Q+  +D + +  R +E+A  +D F+RPLN+R+ LVG+E W   D   +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273

Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
           S +P  +L  FL WR+  LLPR  HD+AQLV+G  F G T+GMA   S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333

Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
           DHS + LG A ++AHELGH+ G++HD     C C        CIM AST +   + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393

Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
           SR+ LE +L  GMG CLF  LP +        CGN FVE GE+CDCG  ++C++ CC++ 
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451

Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
           TC L+P A CA  G CC++CQL+P+G  CR +   CDLPEFC G S  CP +V L DG  
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511

Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
           C      C +G C ++ QQC +LWGPGA+PA  +C +  N+ G+ +G+CG+    S+  C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571

Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
             RDA CG++QCQ G ++P++G+    +   I +  G  + C   H+ LG D+  P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630

Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFG 693
            GT C  G +C++ +CQ + + G  EC  +CHG GVC++ ++C+CE  WAPP C      
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC------ 684

Query: 694 GSTDSGPIRQADNQGLTIGILVTILCLLAAGFV--VYLKRKTLIRLLFTNKKTTIEKLRC 751
                   +      LT G+L+++L LL    +   Y  R  L + L   K  T      
Sbjct: 685 ------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQRLCQLKGPT------ 732

Query: 752 VRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQ 811
                       CQ      G       P   P    P+R L  +    ++  + L+ P 
Sbjct: 733 ------------CQYRAAQSG-------PSERP--GPPQRALLARG---TKQASALSFPA 768

Query: 812 PQSTQRVLPPLHRAPR-------APSVPARPLPAKPALR--QAQGTCKPNPPQKPLPADP 862
           P S  R LPP   + R        P+ P RPLPA P +R  ++QG  KP PP+KPLPADP
Sbjct: 769 PPS--RPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADP 826

Query: 863 LARTTRLTHALARTPGQWETGLRLAPLRPAPQYP 896
                R        PG     L + P RPAP  P
Sbjct: 827 QG---RCPSGDLPGPGAGIPPL-VVPSRPAPPPP 856


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  543 bits (1400), Expect = e-154
 Identities = 326/866 (37%), Positives = 452/866 (52%), Gaps = 62/866 (7%)

Query: 41  EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
           E +   V   DL I +K     + PE L I+L+ +    I+ L +N  L+    T   Y 
Sbjct: 42  EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101

Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
            DGT V ++  +T  L +C Y G VRGY+ S VS+ TCSGLRGL+V   E SY LE    
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158

Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
                 +    +   + G +C           K    PP     +RH   +R+ +  TK 
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214

Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
           VELVIVAD+ E Q+  +D + +  R +E+A  +D F+RPLN+R+ LVG+E W   D   +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273

Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
           S +P  +L  FL WR+  LLPR  HD+AQLV+G  F G T+GMA   S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333

Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
           DHS + LG A ++AHELGH+ G++HD     C C        CIM AST +   + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393

Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
           SR+ LE +L  GMG CLF  LP +        CGN FVE GE+CDCG  ++C++ CC++ 
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451

Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
           TC L+P A CA  G CC++CQL+P+G  CR +   CDLPEFC G S  CP +V L DG  
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511

Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
           C      C +G C ++ QQC +LWGPGA+PA  +C +  N+ G+ +G+CG+    S+  C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571

Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
             RDA CG++QCQ G ++P++G+    +   I +  G  + C   H+ LG D+  P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630

Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFG 693
            GT C  G +C++ +CQ + + G  EC  +CHG GVC++ ++C+CE  WAPP C      
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC------ 684

Query: 694 GSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVR 753
             T       +   GL + +LV +L L+  G   + + +   RL      T   +     
Sbjct: 685 --TTQLKATSSLTTGLLLSLLV-LLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSG 741

Query: 754 PSRPPRGFQPCQAHLGHLGKGLMRKPPDSYP-PKDNPRRLLQCQNVDISRPLNGLNVPQP 812
           PS  P   Q      G     L    P S P P D   + LQ +  D             
Sbjct: 742 PSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSKRLQAELAD------------- 788

Query: 813 QSTQRVLPPLHRAPRAPSVPARPLPAKPALR--QAQGTCKPNPPQKPLPADPLARTTRLT 870
                           P+ P RPLPA P +R  ++QG  KP PP+KPLPADP     R  
Sbjct: 789 ---------------RPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQG---RCP 830

Query: 871 HALARTPGQWETGLRLAPLRPAPQYP 896
                 PG     L + P RPAP  P
Sbjct: 831 SGDLPGPGAGIPPL-VVPSRPAPPPP 855


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  532 bits (1371), Expect = e-151
 Identities = 323/867 (37%), Positives = 450/867 (51%), Gaps = 87/867 (10%)

Query: 41  EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
           E +   V   DL I +K     + PE L I+L+ +    I+ L +N  L+    T   Y 
Sbjct: 42  EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101

Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
            DGT V ++  +T  L +C Y G VRGY+ S VS+ TCSGLRGL+V   E SY LE    
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158

Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
                 +    +   + G +C           K    PP     +RH   +R+ +  TK 
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214

Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
           VELVIVAD+ E Q+  +D + +  R +E+A  +D F+RPLN+R+ LVG+E W   D   +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273

Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
           S +P  +L  FL WR+  LLPR  HD+AQLV+G  F G T+GMA   S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333

Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
           DHS + LG A ++AHELGH+ G++HD     C C        CIM AST +   + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393

Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
           SR+ LE +L  GMG CLF  LP +        CGN FVE GE+CDCG  ++C++ CC++ 
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451

Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
           TC L+P A CA  G CC++CQL+P+G  CR +   CDLPEFC G S  CP +V L DG  
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511

Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
           C      C +G C ++ QQC +LWGPGA+PA  +C +  N+ G+ +G+CG+    S+  C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571

Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
             RDA CG++QCQ G ++P++G+    +   I +  G  + C   H+ LG D+  P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630

Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFG 693
            GT C  G +C++ +CQ + + G  EC  +CHG GVC++ ++C+CE  WAPP C      
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC------ 684

Query: 694 GSTDSGPIRQADNQGLTIGILVTILCLLAAGFV--VYLKRKTLIRLLFTNKKTTIEKLRC 751
                   +      LT G+L+++L LL    +   Y  R  L + L   K  T      
Sbjct: 685 ------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQRLCQLKGPT------ 732

Query: 752 VRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQ 811
                       CQ      G       P   P    P+R L  +    ++  + L+ P 
Sbjct: 733 ------------CQYRAAQSG-------PSERP--GPPQRALLARG---TKQASALSFPA 768

Query: 812 PQSTQRVLPPLHRAPRAPSVPARPLPAKPALR--QAQGTCKPNPPQKPLPADPLARTTRL 869
           P                   P+RPLP  P  +  Q+QG  KP PP+KPLPADP     R 
Sbjct: 769 P-------------------PSRPLPPDPVSKRLQSQGPAKPPPPRKPLPADPQG---RC 806

Query: 870 THALARTPGQWETGLRLAPLRPAPQYP 896
                  PG     L + P RPAP  P
Sbjct: 807 PSGDLPGPGAGIPPL-VVPSRPAPPPP 832


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  530 bits (1366), Expect = e-150
 Identities = 321/867 (37%), Positives = 446/867 (51%), Gaps = 88/867 (10%)

Query: 41  EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
           E +   V   DL I +K     + PE L I+L+ +    I+ L +N  L+    T   Y 
Sbjct: 42  EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101

Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
            DGT V ++  +T  L +C Y G VRGY+ S VS+ TCSGLRGL+V   E SY LE    
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158

Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
                 +    +   + G +C           K    PP     +RH   +R+ +  TK 
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214

Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
           VELVIVAD+ E Q+  +D + +  R +E+A  +D F+RPLN+R+ LVG+E W   D   +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273

Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
           S +P  +L  FL WR+  LLPR  HD+AQLV+G  F G T+GMA   S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333

Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
           DHS + LG A ++AHELGH+ G++HD     C C        CIM AST +   + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393

Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
           SR+ LE +L  GMG CLF  LP +        CGN FVE GE+CDCG  ++C++ CC++ 
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451

Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
           TC L+P A CA  G CC++CQL+P+G  CR +   CDLPEFC G S  CP +V L DG  
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511

Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
           C      C +G C ++ QQC +LWGPGA+PA  +C +  N+ G+ +G+CG+    S+  C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571

Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
             RDA CG++QCQ G ++P++G+    +   I +  G  + C   H+ LG D+  P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630

Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFG 693
            GT C  G +C++ +CQ + + G  EC  +CHG GVC++ ++C+CE  WAPP C      
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC------ 684

Query: 694 GSTDSGPIRQADNQGLTIGILVTILCLLAAGFV--VYLKRKTLIRLLFTNKKTTIEKLRC 751
                   +      LT G+L+++L LL    +   Y  R  L + L   K  T      
Sbjct: 685 ------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQRLCQLKGPT------ 732

Query: 752 VRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQ 811
                       CQ      G      PP               Q   ++R        +
Sbjct: 733 ------------CQYRAAQSGPSERPGPP---------------QRALLARGTKAELADR 765

Query: 812 PQSTQRVLPPLHRAPRAPSVPARPLPAKPALR--QAQGTCKPNPPQKPLPADPLARTTRL 869
           P                 + P RPLPA P +R  ++QG  KP PP+KPLPADP     R 
Sbjct: 766 P-----------------NPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQG---RC 805

Query: 870 THALARTPGQWETGLRLAPLRPAPQYP 896
                  PG     L + P RPAP  P
Sbjct: 806 PSGDLPGPGAGIPPL-VVPSRPAPPPP 831


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  524 bits (1350), Expect = e-148
 Identities = 310/802 (38%), Positives = 436/802 (54%), Gaps = 67/802 (8%)

Query: 72  LQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDS 131
           +Q E KE II+LERN+ L+   F    Y ++GT   L  ++  I  HC+Y G+V G  +S
Sbjct: 70  IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGT---LITDHPNIQNHCHYRGYVEGVHNS 126

Query: 132 AVSLSTCSGLRGLIVFENESYVLEPMKSATN-RYKLFPAKKLKSVRGSCG-SHHNTPNLA 189
           +++LS C GLRGL+  EN SY +EP++++++  + ++    +      CG S+ +     
Sbjct: 127 SIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKET 186

Query: 190 AKNVFP-PPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
           AK+    PPS T   R +R  L  T+YVEL IV D   +   G++   V++ +I +AN++
Sbjct: 187 AKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYL 246

Query: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
           D  Y  LNIRIVLVG+E+W + +  ++       L  F+ WR+  L+ R+ HD+AQLV  
Sbjct: 247 DSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLK 306

Query: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
             F GT  GMA + ++C+   +GGI +         A  +AHELGHN GMNHD   R CS
Sbjct: 307 KGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDD-GRDCS 364

Query: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLET-SLEKGMGVCLFNLPEVRESFGGQKC 427
           C        CIMN+  G      FSSCS +D E  +L KG G CL N+P+  E++    C
Sbjct: 365 CGAK----SCIMNS--GASGSRNFSSCSAEDFEKLTLNKG-GNCLLNIPKPDEAYSAPSC 417

Query: 428 GNRFVEEGEECDCGEPEEC-MNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS 486
           GN+ V+ GEECDCG P+EC ++ CC  +TC LK  A CA+G CC+DC+  P GT CR  +
Sbjct: 418 GNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKT 477

Query: 487 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG 546
           + CD+PE+C G+S  C  +V++ +G+ CQ+   YCYNG+CQ ++ QC  ++G  AK AP 
Sbjct: 478 SECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPK 537

Query: 547 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP 606
            CF  VNS GD +GNCG  S + + KC   +A CGK+QC+     PV G     I+T   
Sbjct: 538 DCFIEVNSKGDRFGNCG-FSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTP-- 594

Query: 607 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ--C 664
             +G +  C G    LG D+PDPG+V  GTKC  GKIC N QC + SV   ++C +Q  C
Sbjct: 595 -SRGTK--CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLN-YDCDVQKKC 650

Query: 665 HGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILV---TILCLL 721
           HG GVCN+ KNCHCE  WAPP C+  G+GGS DSGP     N  L  G+LV    I+ L+
Sbjct: 651 HGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLI 710

Query: 722 AAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPD 781
                +++KR  L R  F  K++   +      + P R  QP                P 
Sbjct: 711 VCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSR--QPGSV-------------PR 755

Query: 782 SYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPA 841
              P   PR +                   P    R   P + A +    P+RP P +P 
Sbjct: 756 HVSPVTPPREV-------------------PIYANRFAVPTYAAKQPQQFPSRPPPPQPK 796

Query: 842 LRQAQGTCKPNPPQKPLPADPL 863
           +  +QG      P +P PA PL
Sbjct: 797 V-SSQGNL---IPARPAPAPPL 814


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  522 bits (1345), Expect = e-148
 Identities = 309/836 (36%), Positives = 424/836 (50%), Gaps = 107/836 (12%)

Query: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
           HPE ++  L        ++L +N  L+ S +TET+   +G++V+          HC+Y G
Sbjct: 53  HPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQ---DHCFYQG 109

Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATN--RYKLFPAKKLKSVRGSCGS 181
           HV GY DSA SLSTC+GLRG     ++ +++EP+       R+ ++ A+ L    G+CG 
Sbjct: 110 HVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGV 169

Query: 182 HHNT------PNLAAKNVFPP-PSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
             ++      P  AA  VF P P  +   R        T+YVEL +V DN EFQ  G + 
Sbjct: 170 SDDSLGSLLGPRTAA--VFRPRPGDSLPSRE-------TRYVELYVVVDNAEFQMLGSEA 220

Query: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294
             V+ R++E+ NHVDK Y+ LN R+VLVG+E+WN  D+  VS DP  +L   L W+  + 
Sbjct: 221 A-VRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQR 279

Query: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354
             R  HDN QL++GV F GTT+G A + +MC+   SG +  DHS NP+G A T+AHE+GH
Sbjct: 280 TRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGH 338

Query: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
           N GM+HD   +GC CQ   E G CIM  S G  FP +FS CS+  LE+ LE+   VCL N
Sbjct: 339 NLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLAN 398

Query: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474
            P++    GG  CGN FVE GE+CDCG PE+C NRCCN+TTC L   A CAHG CC++C+
Sbjct: 399 APDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECK 458

Query: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534
           +KPAG  CR   + CDL EFC G  P CP + +  +G  C    GYCYNG C T  QQC 
Sbjct: 459 VKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCS--GGYCYNGACPTLAQQCQ 516

Query: 535 TLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVI 594
             WGPG + A   CF     + D    C    K+S  + +M    CG +QC+GG      
Sbjct: 517 AFWGPGGQAAEESCF-----SYDILPGC----KASRYRADM----CGVLQCKGGQ----- 558

Query: 595 GTNAVSIETNIPLQQGGRILC--RGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNI 652
                        Q  GR +C     H    +D      V  GT+C   K+C   +CQ++
Sbjct: 559 -------------QPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDL 605

Query: 653 SVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIG 712
            V+    C+ QCH  GVCN+++ CHC A WAPP C K        SG +       + + 
Sbjct: 606 HVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVF---VVVVL 662

Query: 713 ILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTI---------------EKLRCVRPSRP 757
           +L+ ++ +  AG +VY K ++ I       KTT+                K     PSR 
Sbjct: 663 VLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRG 722

Query: 758 PRGFQPCQAHLG----HLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQ 813
           P+   P   H G    H    +  K P   PP            V +S P   + V   Q
Sbjct: 723 PQELVP-TTHPGQPARHPASSVALKRPPPAPP------------VTVSSPPFPVPVYTRQ 769

Query: 814 STQRVLPPLHRAPRAPSVP----ARPLPA----------KPALRQAQGTCKPNPPQ 855
           + ++V+ P    P  P  P    A P PA          KP +++ QG   P  P+
Sbjct: 770 APKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAELPQHPR 825


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  520 bits (1338), Expect = e-147
 Identities = 303/809 (37%), Positives = 431/809 (53%), Gaps = 48/809 (5%)

Query: 41  EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
           E +   V   DL I +K     + PE L I+L+ +    I+ L +N  L+    T   Y 
Sbjct: 42  EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101

Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
            DGT V ++  +T  L +C Y G VRGY+ S VS+ TCSGLRGL+V   E SY LE    
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158

Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
                 +    +   + G +C           K    PP     +RH   +R+ +  TK 
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214

Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
           VELVIVAD+ E Q+  +D + +  R +E+A  +D F+RPLN+R+ LVG+E W   D   +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273

Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
           S +P  +L  FL WR+  LLPR  HD+AQLV+G  F G T+GMA   S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333

Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
           DHS + LG A ++AHELGH+ G++HD     C C        CIM AST +   + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393

Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
           SR+ LE +L  GMG CLF  LP +        CGN FVE GE+CDCG  ++C++ CC++ 
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451

Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
           TC L+P A CA  G CC++CQL+P+G  CR +   CDLPEFC G S  CP +V L DG  
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511

Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
           C      C +G C ++ QQC +LWGPGA+PA  +C +  N+ G+ +G+CG+    S+  C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571

Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
             RDA CG++QCQ G ++P++G+    +   I +  G  + C   H+ LG D+  P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630

Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFG 693
            GT C  G +C++ +CQ + + G  EC  +CHG GVC++ ++C+CE  WAPP C      
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC------ 684

Query: 694 GSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVR 753
             T       +   GL + +LV +L L+  G   + + +   RL      T   +     
Sbjct: 685 --TTQLKATSSLTTGLLLSLLV-LLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSG 741

Query: 754 PSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQ 813
           PS  P   Q      G   +G  + PP   P   +P+   +C + D+  P  G       
Sbjct: 742 PSERPGPPQRALLARGTKSQGPAKPPPPRKPLPADPQG--RCPSGDLPGPGAG------- 792

Query: 814 STQRVLPPLHRAPRAPSVPARPLPAKPAL 842
                +PPL        VP+RP P  P +
Sbjct: 793 -----IPPL-------VVPSRPAPPPPTV 809



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 28/68 (41%), Positives = 33/68 (48%), Gaps = 6/68 (8%)

Query: 829 PSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAP 888
           P  P R L A+    ++QG  KP PP+KPLPADP     R        PG     L + P
Sbjct: 746 PGPPQRALLARGT--KSQGPAKPPPPRKPLPADPQG---RCPSGDLPGPGAGIPPL-VVP 799

Query: 889 LRPAPQYP 896
            RPAP  P
Sbjct: 800 SRPAPPPP 807


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score =  512 bits (1319), Expect = e-145
 Identities = 286/729 (39%), Positives = 405/729 (55%), Gaps = 32/729 (4%)

Query: 41  EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
           E +   V   DL I +K     + PE L I+L+ +    I+ L +N  L+    T   Y 
Sbjct: 42  EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101

Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
            DGT V ++  +T  L +C Y G VRGY+ S VS+ TCSGLRGL+V   E SY LE    
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158

Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
                 +    +   + G +C           K    PP     +RH   +R+ +  TK 
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214

Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
           VELVIVAD+ E Q+  +D + +  R +E+A  +D F+RPLN+R+ LVG+E W   D   +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273

Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
           S +P  +L  FL WR+  LLPR  HD+AQLV+G  F G T+GMA   S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333

Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
           DHS + LG A ++AHELGH+ G++HD     C C        CIM AST +   + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393

Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
           SR+ LE +L  GMG CLF  LP +        CGN FVE GE+CDCG  ++C++ CC++ 
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451

Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
           TC L+P A CA  G CC++CQL+P+G  CR +   CDLPEFC G S  CP +V L DG  
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511

Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
           C      C +G C ++ QQC +LWGPGA+PA  +C +  N+ G+ +G+CG+    S+  C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571

Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
             RDA CG++QCQ G ++P++G+    +   I +  G  + C   H+ LG D+  P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630

Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFG 693
            GT C  G +C++ +CQ + + G  EC  +CHG GVC++ ++C+CE  WAPP C      
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC------ 684

Query: 694 GSTDSGPIRQADNQGLTIGILVTILCLLAAGFV--VYLKRKTLIRLLFTNKKTTIEKLRC 751
                   +      LT G+L+++L LL    +   Y  R  L + L   K  T +    
Sbjct: 685 ------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYSLR 738

Query: 752 VRPSRPPRG 760
            +PS  P+G
Sbjct: 739 GQPSPHPQG 747


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  430 bits (1105), Expect = e-120
 Identities = 233/637 (36%), Positives = 339/637 (53%), Gaps = 52/637 (8%)

Query: 68  LNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRG 127
           L  ++    K  ++ L++N+ L+A  +TET+Y   G +++ +     I+  CYY GH+  
Sbjct: 57  LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQ---IMDDCYYQGHILN 113

Query: 128 YSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-------YKLFPAKKLKSVRGSCG 180
              S  S+STC GLRG     ++ Y +EP+ S  +R       +K  P +K  +   +CG
Sbjct: 114 EKVSDASISTCRGLRGYFSQGDQRYFIEPL-SPIHRDGQEHALFKYNPDEK--NYDSTCG 170

Query: 181 ------SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
                 +H    N+A       P+    +   R+  +  KY+E  +V DN EF+R  ++ 
Sbjct: 171 MDGVLWAHDLQQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQ 224

Query: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294
           +++++R+ E+AN+V+  Y+ LN  + LVG+E+W D DK  ++ +   +L  F  WR   L
Sbjct: 225 DEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVL 284

Query: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354
             RK HD AQL++     GTT+G+A + +MC+   S G+V DHSDN L  A T+AHE+GH
Sbjct: 285 SRRKRHDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGH 343

Query: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
           NFGM HD  D  C C   +    C+M+ +  +  P  FSSCSR   +   E  +  CLFN
Sbjct: 344 NFGMFHD--DYSCKCPSTI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397

Query: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474
            P   +      CGN+ VE GE+CDCG  EEC N CC+A TC +K    CA G CCE CQ
Sbjct: 398 APLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQ 457

Query: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534
            K AG  CR + + CDLPE C G S +CP + +  +G  C    G+C  G C T ++QC 
Sbjct: 458 FKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCT 517

Query: 535 TLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVI 594
            LWGPG + A   C+ R N  G  YG C +V   +   C+  D  CGK+ CQGG+     
Sbjct: 518 ELWGPGTEVADKSCYNR-NEGGSKYGYCRRVD-DTLIPCKANDTMCGKLFCQGGSD---- 571

Query: 595 GTNAVSIETNIPLQQGGRILCRGTHVYLG--DDMPDPGLVLAGTKCADGKICLNRQCQNI 652
                    N+P +  GRI+   T       D   + G+V  GTKC D K+C+N +C +I
Sbjct: 572 ---------NLPWK--GRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDI 620

Query: 653 -SVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCD 688
              +    C+ +C G  VC++   C CE  W PP CD
Sbjct: 621 EKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCD 657


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  387 bits (994), Expect = e-107
 Identities = 223/672 (33%), Positives = 346/672 (51%), Gaps = 35/672 (5%)

Query: 62  KNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYY 121
           K + E L   ++   K L+++L R+   + S+++ET Y   G   +    +  I+ HC+Y
Sbjct: 53  KTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFT---RHPQIMDHCFY 109

Query: 122 HGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMK-SATNRYKLFPAKKLKSVRGSCG 180
            G +    DSA S+STC+GLRG     ++ Y++EP+K S    + +F      ++R   G
Sbjct: 110 QGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKY----NLRVPYG 165

Query: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
           ++++   L       P         K + +   KYVEL IVAD+  ++R G    K++ R
Sbjct: 166 ANYSCTELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNR 225

Query: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
           +  + N V+  Y+ LNI + LVG+E+W   DK  +  +  T+L  F  W++  L  RK  
Sbjct: 226 IWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDF 285

Query: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
           D+  L+SG +      G++    MC    S  I+ D   +    A  +AH+LGHN GM H
Sbjct: 286 DHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQH 345

Query: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
           D     C+C      G C+M++    P  + FS CS+      L+     C+ N+P    
Sbjct: 346 DEFP--CTCP----SGKCVMDSDGSIP-ALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYN 398

Query: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
               Q CGN+ ++EGEECDCG  +EC N CC+A TC LKP   CA G CCE CQ+K AG+
Sbjct: 399 FHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGS 458

Query: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
            CR + + CD PE CTG SP CP + +  +G  C++ +GYC+ G C T E QC  L+   
Sbjct: 459 ICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDE 518

Query: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
           A  +  IC+ ++N+ G+ +G C K  ++ F  CE +D +CGKI C GG    ++G +  +
Sbjct: 519 AIESHDICY-KMNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDK-T 575

Query: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNI-SVFGVHE 659
                P Q+   + C+   ++L  D  D GLV +GTKC +G +C N +C N+  V+    
Sbjct: 576 YHLKDP-QKNATVKCK--TIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTN 632

Query: 660 CAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILC 719
           C  QC+   V  +   CHCE   AP  C++                   +TI ++V +L 
Sbjct: 633 CPSQCNENPVDGHGLQCHCEEGQAPVACEE-------------TLHVTNITILVVVLVLV 679

Query: 720 LLAAGFVVYLKR 731
           ++  G ++ L R
Sbjct: 680 IVGIGVLILLVR 691


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  372 bits (954), Expect = e-102
 Identities = 225/706 (31%), Positives = 341/706 (48%), Gaps = 56/706 (7%)

Query: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
           H +  + ++       I+++  N  L++S + E H    G  V +         HCYY G
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139

Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
           H+RG  DS V+LSTC GL G+    N +Y++EP ++ T +     + ++ ++  +     
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199

Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
             S     N+          P  S+   RR+ R   + TKY+EL+IV D+  F++    +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
                    + N  D  Y+  L  RIVLV +E W   +K ++S++P  +L EF+ +R+  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
           +  ++  D   L SG  F+ +  G A I  +C+  + GG+      N  G     AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371

Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
             L HN G+  D        C+      GCIM   TGY  P  F+ C+ ++    L  G 
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430

Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
           G CLFN P   +     +CGN F+E GEECDCG P EC+     CC    CTL  D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486

Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
            GLCC+ C+ +P GT CR++ N CD+ E C+G S  C  N++  DG+SC  V G C+ G 
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546

Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
           C+T ++QC  +WG     +   C+E++N  G   GNCGK  K ++ +C  RD  CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605

Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
               + P +G     I + + +QQG  + C G HV L +D+ D G V  GT C    +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664

Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
             +C  ++ F    C        C G GVC+N   C C  HW    C+ + F  + D+  
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY-FPHNDDAKT 723

Query: 701 IRQADNQGL------------TIGILVTILCLLAAGFVVYLKRKTL 734
                  G+            TI +L  IL + A G+  Y +++ L
Sbjct: 724 GITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQL 769


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score =  372 bits (954), Expect = e-102
 Identities = 225/706 (31%), Positives = 341/706 (48%), Gaps = 56/706 (7%)

Query: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
           H +  + ++       I+++  N  L++S + E H    G  V +         HCYY G
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139

Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
           H+RG  DS V+LSTC GL G+    N +Y++EP ++ T +     + ++ ++  +     
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199

Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
             S     N+          P  S+   RR+ R   + TKY+EL+IV D+  F++    +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
                    + N  D  Y+  L  RIVLV +E W   +K ++S++P  +L EF+ +R+  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
           +  ++  D   L SG  F+ +  G A I  +C+  + GG+      N  G     AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371

Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
             L HN G+  D        C+      GCIM   TGY  P  F+ C+ ++    L  G 
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430

Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
           G CLFN P   +     +CGN F+E GEECDCG P EC+     CC    CTL  D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486

Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
            GLCC+ C+ +P GT CR++ N CD+ E C+G S  C  N++  DG+SC  V G C+ G 
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546

Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
           C+T ++QC  +WG     +   C+E++N  G   GNCGK  K ++ +C  RD  CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605

Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
               + P +G     I + + +QQG  + C G HV L +D+ D G V  GT C    +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664

Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
             +C  ++ F    C        C G GVC+N   C C  HW    C+ + F  + D+  
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY-FPHNDDAKT 723

Query: 701 IRQADNQGL------------TIGILVTILCLLAAGFVVYLKRKTL 734
                  G+            TI +L  IL + A G+  Y +++ L
Sbjct: 724 GITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQL 769


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  371 bits (952), Expect = e-102
 Identities = 224/705 (31%), Positives = 341/705 (48%), Gaps = 56/705 (7%)

Query: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
           H +  + ++       I+++  N  L++S + E H    G  V +         HCYY G
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139

Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
           H+RG  DS V+LSTC GL G+    N +Y++EP ++ T +     + ++ ++  +     
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199

Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
             S     N+          P  S+   RR+ R   + TKY+EL+IV D+  F++    +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
                    + N  D  Y+  L  RIVLV +E W   +K ++S++P  +L EF+ +R+  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
           +  ++  D   L SG  F+ +  G A I  +C+  + GG+      N  G     AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371

Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
             L HN G+  D        C+      GCIM   TGY  P  F+ C+ ++    L  G 
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430

Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
           G CLFN P   +     +CGN F+E GEECDCG P EC+     CC    CTL  D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486

Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
            GLCC+ C+ +P GT CR++ N CD+ E C+G S  C  N++  DG+SC  V G C+ G 
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546

Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
           C+T ++QC  +WG     +   C+E++N  G   GNCGK  K ++ +C  RD  CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605

Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
               + P +G     I + + +QQG  + C G HV L +D+ D G V  GT C    +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664

Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
             +C  ++ F    C        C G GVC+N   C C  HW    C+ + F  + D+  
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY-FPHNDDAKT 723

Query: 701 IRQADNQGL------------TIGILVTILCLLAAGFVVYLKRKT 733
                  G+            TI +L  IL + A G+  Y ++++
Sbjct: 724 GITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRS 768


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  371 bits (952), Expect = e-102
 Identities = 224/705 (31%), Positives = 341/705 (48%), Gaps = 56/705 (7%)

Query: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
           H +  + ++       I+++  N  L++S + E H    G  V +         HCYY G
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139

Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
           H+RG  DS V+LSTC GL G+    N +Y++EP ++ T +     + ++ ++  +     
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199

Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
             S     N+          P  S+   RR+ R   + TKY+EL+IV D+  F++    +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
                    + N  D  Y+  L  RIVLV +E W   +K ++S++P  +L EF+ +R+  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
           +  ++  D   L SG  F+ +  G A I  +C+  + GG+      N  G     AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371

Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
             L HN G+  D        C+      GCIM   TGY  P  F+ C+ ++    L  G 
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430

Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
           G CLFN P   +     +CGN F+E GEECDCG P EC+     CC    CTL  D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486

Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
            GLCC+ C+ +P GT CR++ N CD+ E C+G S  C  N++  DG+SC  V G C+ G 
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546

Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
           C+T ++QC  +WG     +   C+E++N  G   GNCGK  K ++ +C  RD  CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605

Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
               + P +G     I + + +QQG  + C G HV L +D+ D G V  GT C    +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664

Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
             +C  ++ F    C        C G GVC+N   C C  HW    C+ + F  + D+  
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY-FPHNDDAKT 723

Query: 701 IRQADNQGL------------TIGILVTILCLLAAGFVVYLKRKT 733
                  G+            TI +L  IL + A G+  Y ++++
Sbjct: 724 GITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRS 768


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  371 bits (952), Expect = e-102
 Identities = 224/705 (31%), Positives = 341/705 (48%), Gaps = 56/705 (7%)

Query: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
           H +  + ++       I+++  N  L++S + E H    G  V +         HCYY G
Sbjct: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139

Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
           H+RG  DS V+LSTC GL G+    N +Y++EP ++ T +     + ++ ++  +     
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199

Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
             S     N+          P  S+   RR+ R   + TKY+EL+IV D+  F++    +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259

Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
                    + N  D  Y+  L  RIVLV +E W   +K ++S++P  +L EF+ +R+  
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319

Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
           +  ++  D   L SG  F+ +  G A I  +C+  + GG+      N  G     AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371

Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
             L HN G+  D        C+      GCIM   TGY  P  F+ C+ ++    L  G 
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430

Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
           G CLFN P   +     +CGN F+E GEECDCG P EC+     CC    CTL  D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486

Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
            GLCC+ C+ +P GT CR++ N CD+ E C+G S  C  N++  DG+SC  V G C+ G 
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546

Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
           C+T ++QC  +WG     +   C+E++N  G   GNCGK  K ++ +C  RD  CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605

Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
               + P +G     I + + +QQG  + C G HV L +D+ D G V  GT C    +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664

Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
             +C  ++ F    C        C G GVC+N   C C  HW    C+ + F  + D+  
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY-FPHNDDAKT 723

Query: 701 IRQADNQGL------------TIGILVTILCLLAAGFVVYLKRKT 733
                  G+            TI +L  IL + A G+  Y ++++
Sbjct: 724 GITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRS 768


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  368 bits (944), Expect = e-101
 Identities = 231/713 (32%), Positives = 355/713 (49%), Gaps = 53/713 (7%)

Query: 30  GVSLWNQGRADEVVSASVGSGDLWIPVKSFD---SKNHPEVLNIRLQRESKELIINLERN 86
           G+ L   G +    S    S ++ IP+K          P  L+  L+   +  I+++  N
Sbjct: 70  GMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQRYIVHMRVN 129

Query: 87  EGLIAS-----SFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSG- 140
           + L A+     ++TE H        +L ++   I   CYYHG+V G  +S V+LSTCSG 
Sbjct: 130 KLLFAAHLPVFTYTEQH--------ALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGG 181

Query: 141 LRGLIVFENESYVLEPMK-SATNRYKLFP--AKKLKSVRGSCG------SHHNTPNLAAK 191
             G++   +  Y ++P+  SAT  + ++   +   +     CG      +H     L+  
Sbjct: 182 FLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYN 241

Query: 192 NVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKF 251
                 S      H+R       +VELV+V DN  +     +   V+  +  + N VD F
Sbjct: 242 FTLKQSSFVGWWTHQR-------FVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSF 294

Query: 252 YRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYF 311
           Y PL + ++L G+++W   +    S D    L +F  W+   L  R  HD A L      
Sbjct: 295 YHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDT- 353

Query: 312 QGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQM 371
           QG  +G+A +  +C    + G+ +   +  +  A+TL HELGHN GM HDT  + C C++
Sbjct: 354 QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDT--QWCVCEL 411

Query: 372 AVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRF 431
                 CIM+A         FS+CS      S     G+C+   P     F  + CGN  
Sbjct: 412 Q----WCIMHAYR--KVTTKFSNCSYAQYWDSTISS-GLCIQPPPYPGNIFRLKYCGNLV 464

Query: 432 VEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDL 491
           VEEGEECDCG   +C    C    CTL P A CA G+CC+DC+  P+GT CR     CDL
Sbjct: 465 VEEGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDL 524

Query: 492 PEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFER 551
           PE+C G S  CP +VY+ DG SC +V+ +CY   C  H+ QC  ++G  A+ A   C++ 
Sbjct: 525 PEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQE 583

Query: 552 VNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGG 611
           +N+ G+ +G+CG V  +++ KC   D  CG++QC+     P +  ++   + ++      
Sbjct: 584 INTQGNRFGHCGIVG-TTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHL-----N 637

Query: 612 RILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCN 671
              C GT  +LG  +PD G V  GT C   KIC+ ++C ++           C+ RG+CN
Sbjct: 638 DTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICN 697

Query: 672 NRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTI-GIL--VTILCLL 721
           N+++CHC   WAPP+C   G+GGS DSGP  + + +GL + G L  +++LCLL
Sbjct: 698 NKQHCHCNHEWAPPYCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLL 750


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  363 bits (931), Expect = e-100
 Identities = 246/850 (28%), Positives = 396/850 (46%), Gaps = 88/850 (10%)

Query: 51  DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
           D+ IPV+   +      P  L+  L    ++ II+++  + L +       Y   G   +
Sbjct: 32  DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88

Query: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
           +  +   +  +CYYHG+V G  +S VSLSTC  G +G++   + +Y ++P+  +T     
Sbjct: 89  ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148

Query: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
            YK+    K+  ++R     +  T  +  + +               T K + Y      
Sbjct: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196

Query: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
              VE+V+V DN  + R  ++  K+ + L  I N VD     + ++++L G+E+W + + 
Sbjct: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255

Query: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
             V  D   S+H +  W+   + PR  HD + L + +  +G + G+     MCT  +S  
Sbjct: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314

Query: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
           IV   +      ++ +AH LGHN GMNHD  +  C C     +  CIM+   G P    F
Sbjct: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366

Query: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
           S+CS  D  E ++E+    CL      ++ F  ++CGN  VEEGEECDCG  + C    C
Sbjct: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424

Query: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
             + CTL   + CA GLCC+DC+  P+G  CR   N CDLPE+C G S  CP + Y+ DG
Sbjct: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484

Query: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
             C++  GYCY   C    +QC  ++G GA  A   C++ +N+ GD  G+CG +  +++ 
Sbjct: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542

Query: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
           KC + D +CG+IQC+     P      +S  T +   +   I+C  T  +LG   PD G 
Sbjct: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597

Query: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
           V  GT+C    IC++R C +I++   +     C+ RG+CNN+ +CHC   W PP C   G
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657

Query: 692 FGGSTDSGPIRQADNQG----LTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIE 747
           +GGS DSGP  +   +     L I +L+ +  LL   +                      
Sbjct: 658 YGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLY---------------------- 695

Query: 748 KLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGL 807
             R  + S+P +  Q  Q       + + R+P +  PP+  P  ++  Q+     P    
Sbjct: 696 --RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHE-LPPQSQP-WVMPSQSQPPVTPSQSH 751

Query: 808 NVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTT 867
               P  +Q  + P    PR       P  ++P +  +Q   +  P Q   P  P  R  
Sbjct: 752 PQVMPSQSQPPVTPSQSQPR-----VMPSQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQP 806

Query: 868 RLTHALARTP 877
           +L  + ++ P
Sbjct: 807 QLMPSQSQPP 816


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  363 bits (931), Expect = e-100
 Identities = 246/850 (28%), Positives = 396/850 (46%), Gaps = 88/850 (10%)

Query: 51  DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
           D+ IPV+   +      P  L+  L    ++ II+++  + L +       Y   G   +
Sbjct: 32  DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88

Query: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
           +  +   +  +CYYHG+V G  +S VSLSTC  G +G++   + +Y ++P+  +T     
Sbjct: 89  ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148

Query: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
            YK+    K+  ++R     +  T  +  + +               T K + Y      
Sbjct: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196

Query: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
              VE+V+V DN  + R  ++  K+ + L  I N VD     + ++++L G+E+W + + 
Sbjct: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255

Query: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
             V  D   S+H +  W+   + PR  HD + L + +  +G + G+     MCT  +S  
Sbjct: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314

Query: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
           IV   +      ++ +AH LGHN GMNHD  +  C C     +  CIM+   G P    F
Sbjct: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366

Query: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
           S+CS  D  E ++E+    CL      ++ F  ++CGN  VEEGEECDCG  + C    C
Sbjct: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424

Query: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
             + CTL   + CA GLCC+DC+  P+G  CR   N CDLPE+C G S  CP + Y+ DG
Sbjct: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484

Query: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
             C++  GYCY   C    +QC  ++G GA  A   C++ +N+ GD  G+CG +  +++ 
Sbjct: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542

Query: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
           KC + D +CG+IQC+     P      +S  T +   +   I+C  T  +LG   PD G 
Sbjct: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597

Query: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
           V  GT+C    IC++R C +I++   +     C+ RG+CNN+ +CHC   W PP C   G
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657

Query: 692 FGGSTDSGPIRQADNQG----LTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIE 747
           +GGS DSGP  +   +     L I +L+ +  LL   +                      
Sbjct: 658 YGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLY---------------------- 695

Query: 748 KLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGL 807
             R  + S+P +  Q  Q       + + R+P +  PP+  P  ++  Q+     P    
Sbjct: 696 --RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHE-LPPQSQP-WVMPSQSQPPVTPSQSH 751

Query: 808 NVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTT 867
               P  +Q  + P    PR       P  ++P +  +Q   +  P Q   P  P  R  
Sbjct: 752 PQVMPSQSQPPVTPSQSQPR-----VMPSQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQP 806

Query: 868 RLTHALARTP 877
           +L  + ++ P
Sbjct: 807 QLMPSQSQPP 816


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  363 bits (931), Expect = e-100
 Identities = 246/850 (28%), Positives = 396/850 (46%), Gaps = 88/850 (10%)

Query: 51  DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
           D+ IPV+   +      P  L+  L    ++ II+++  + L +       Y   G   +
Sbjct: 32  DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88

Query: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
           +  +   +  +CYYHG+V G  +S VSLSTC  G +G++   + +Y ++P+  +T     
Sbjct: 89  ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148

Query: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
            YK+    K+  ++R     +  T  +  + +               T K + Y      
Sbjct: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196

Query: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
              VE+V+V DN  + R  ++  K+ + L  I N VD     + ++++L G+E+W + + 
Sbjct: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255

Query: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
             V  D   S+H +  W+   + PR  HD + L + +  +G + G+     MCT  +S  
Sbjct: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314

Query: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
           IV   +      ++ +AH LGHN GMNHD  +  C C     +  CIM+   G P    F
Sbjct: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366

Query: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
           S+CS  D  E ++E+    CL      ++ F  ++CGN  VEEGEECDCG  + C    C
Sbjct: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424

Query: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
             + CTL   + CA GLCC+DC+  P+G  CR   N CDLPE+C G S  CP + Y+ DG
Sbjct: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484

Query: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
             C++  GYCY   C    +QC  ++G GA  A   C++ +N+ GD  G+CG +  +++ 
Sbjct: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542

Query: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
           KC + D +CG+IQC+     P      +S  T +   +   I+C  T  +LG   PD G 
Sbjct: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597

Query: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
           V  GT+C    IC++R C +I++   +     C+ RG+CNN+ +CHC   W PP C   G
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657

Query: 692 FGGSTDSGPIRQADNQG----LTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIE 747
           +GGS DSGP  +   +     L I +L+ +  LL   +                      
Sbjct: 658 YGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLY---------------------- 695

Query: 748 KLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGL 807
             R  + S+P +  Q  Q       + + R+P +  PP+  P  ++  Q+     P    
Sbjct: 696 --RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHE-LPPQSQP-WVMPSQSQPPVTPSQSH 751

Query: 808 NVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTT 867
               P  +Q  + P    PR       P  ++P +  +Q   +  P Q   P  P  R  
Sbjct: 752 PQVMPSQSQPPVTPSQSQPR-----VMPSQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQP 806

Query: 868 RLTHALARTP 877
           +L  + ++ P
Sbjct: 807 QLMPSQSQPP 816


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  363 bits (931), Expect = e-100
 Identities = 246/850 (28%), Positives = 396/850 (46%), Gaps = 88/850 (10%)

Query: 51  DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
           D+ IPV+   +      P  L+  L    ++ II+++  + L +       Y   G   +
Sbjct: 32  DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88

Query: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
           +  +   +  +CYYHG+V G  +S VSLSTC  G +G++   + +Y ++P+  +T     
Sbjct: 89  ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148

Query: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
            YK+    K+  ++R     +  T  +  + +               T K + Y      
Sbjct: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196

Query: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
              VE+V+V DN  + R  ++  K+ + L  I N VD     + ++++L G+E+W + + 
Sbjct: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255

Query: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
             V  D   S+H +  W+   + PR  HD + L + +  +G + G+     MCT  +S  
Sbjct: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314

Query: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
           IV   +      ++ +AH LGHN GMNHD  +  C C     +  CIM+   G P    F
Sbjct: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366

Query: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
           S+CS  D  E ++E+    CL      ++ F  ++CGN  VEEGEECDCG  + C    C
Sbjct: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424

Query: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
             + CTL   + CA GLCC+DC+  P+G  CR   N CDLPE+C G S  CP + Y+ DG
Sbjct: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484

Query: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
             C++  GYCY   C    +QC  ++G GA  A   C++ +N+ GD  G+CG +  +++ 
Sbjct: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542

Query: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
           KC + D +CG+IQC+     P      +S  T +   +   I+C  T  +LG   PD G 
Sbjct: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597

Query: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
           V  GT+C    IC++R C +I++   +     C+ RG+CNN+ +CHC   W PP C   G
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657

Query: 692 FGGSTDSGPIRQADNQG----LTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIE 747
           +GGS DSGP  +   +     L I +L+ +  LL   +                      
Sbjct: 658 YGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLY---------------------- 695

Query: 748 KLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGL 807
             R  + S+P +  Q  Q       + + R+P +  PP+  P  ++  Q+     P    
Sbjct: 696 --RLCKKSKPIKKQQDVQTPSAKEEEKIQRRPHE-LPPQSQP-WVMPSQSQPPVTPSQSH 751

Query: 808 NVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTT 867
               P  +Q  + P    PR       P  ++P +  +Q   +  P Q   P  P  R  
Sbjct: 752 PQVMPSQSQPPVTPSQSQPR-----VMPSQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQP 806

Query: 868 RLTHALARTP 877
           +L  + ++ P
Sbjct: 807 QLMPSQSQPP 816


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  354 bits (909), Expect = 2e-97
 Identities = 212/645 (32%), Positives = 307/645 (47%), Gaps = 44/645 (6%)

Query: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
           H    + +++    + I++L  N GL++S + E HY       S          HCYYHG
Sbjct: 147 HLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGE------HCYYHG 200

Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMK-----SATNRYKLFPAKKLKSVRGS 178
            +RG  DS V+LSTC+GL G+   +   Y++EP++      +T R  +      K++ G 
Sbjct: 201 SIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQ----KTLAGQ 256

Query: 179 CGSHHNTPNLAAKNVFPPPSQT-WARRHKRET------LKATKYVELVIVADNREFQRQG 231
                    +   + +P  S+  W +R KR         +  KY+EL+IV D++ +++  
Sbjct: 257 YSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHR 316

Query: 232 KDLEKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWR 290
                       + N VD  Y+  LN R+VLV VE W + D+  ++ +P   LHEF  +R
Sbjct: 317 SSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYR 376

Query: 291 KMKLLPRKSH-DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLA 349
           +      K H D   L+S V F      ++    +C+  ++ G+ ++    P+  A  L+
Sbjct: 377 QRI----KQHADAVHLISRVTFHYKRSSLSYFGGVCS--RTRGVGVNEYGLPMAVAQVLS 430

Query: 350 HELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMG 409
             L  N G+  +   R   C      GGCIM   TG      FS CS  +    L++G G
Sbjct: 431 QSLAQNLGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGG 489

Query: 410 VCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLC 469
            CLFN P   + F   +CGN +VE GEECDCG   EC   CC    C+L   A C+ G C
Sbjct: 490 ACLFNRPT--KLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHCSDGPC 545

Query: 470 CED--CQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQ 527
           C +  C  +P G  CRD+ N CD+ E+CTG S  CP N++  DG++C    G CYNG C+
Sbjct: 546 CNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECK 605

Query: 528 THEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQG 587
           T + QC  +WG  A  +   C+E++N+ G   GNCGK     + +C   D  CG + C  
Sbjct: 606 TRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGK-DGDRWIQCSKHDVFCGFLLCTN 664

Query: 588 GASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNR 647
               P IG     I       QG  I C G HV L DD  D G V  GT C    +CL+R
Sbjct: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDD-TDVGYVEDGTPCGPSMMCLDR 723

Query: 648 QCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFC 687
           +C  I    +  C +      C G GVC+N   C C+  WA   C
Sbjct: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDC 768


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score =  354 bits (909), Expect = 2e-97
 Identities = 230/731 (31%), Positives = 364/731 (49%), Gaps = 70/731 (9%)

Query: 30  GVSLWNQGRADEVVSASVGSGDLWIPVKSFD---SKNHPEVLNIRLQRESKELIINLERN 86
           GV L   G      S    S ++ IP+K      S   P  L+  L+   ++ ++++   
Sbjct: 20  GVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVK 79

Query: 87  EGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLI 145
           + L++       Y  +    +L  +   I   CYYHG+V G  +S V  S C  G RG++
Sbjct: 80  KLLVSRHLPVFTYTDER---ALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFGGFRGVL 136

Query: 146 VFENESYVLEPMK-SATNR---YKL------FPAKKLKSVRGSCGSHHNTPNLAAKNVFP 195
                +Y +EP++ SAT     YK+      FPA +                 A  +   
Sbjct: 137 KISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEAENSALE 196

Query: 196 PPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPL 255
           P S      H         ++ELV+V ++  F     ++ KV++ +  + N VD  Y+ L
Sbjct: 197 PKSAGDWWTH-------AWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249

Query: 256 NIRIVLVGVEVWNDMDKCSVSQDPFTS----LHEFLDWRKMKLLPRKSHDNAQLVSGVYF 311
              I+L+G+E+WN  +       P TS    L++F  W+++ L  +  HD A +    + 
Sbjct: 250 GTYIILIGIEIWNQGNVF-----PMTSIEQVLNDFSQWKQISL-SQLQHDAAHM----FI 299

Query: 312 QGTTI---GMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
           + + I   G+A +  +C      G+     D     A T+AHELGH  GM HD  +  C 
Sbjct: 300 KNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD--EEFCF 357

Query: 369 CQMAVEKGGCIMNASTGYPFPMV-FSSCSRKD-LETSLEKGMGVCLFNLPEVRESFGGQK 426
           C     + GCIMN    +  P   F++CS  D ++T+L +G   CL N P + E F  ++
Sbjct: 358 CG----ERGCIMNT---FRVPAEKFTNCSYADFMKTTLNQGS--CLHNPPRLGEIFMLKR 408

Query: 427 CGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS 486
           CGN  VE  E+CDCG  ++C    C    CTL+P A CA GLCC+DC+  P+G  CR   
Sbjct: 409 CGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEV 468

Query: 487 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG 546
           N CDLPE+C G S  CP + Y+ DG  C D   YCY   C  H+Q C  ++G  AK A  
Sbjct: 469 NECDLPEWCNGTSHQCPEDRYVQDGIPCSD-SAYCYQKRCNNHDQHCREIFGKDAKSASQ 527

Query: 547 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP 606
            C++ +NS G+ +G+CG ++ +++ KC + D  CG++QC+     P++  +     T+I 
Sbjct: 528 NCYKEINSQGNRFGHCG-INGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHI- 585

Query: 607 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ-CH 665
                 + C G   +L  ++ D G V  GT C  GKIC++++C ++SV   H C  + C+
Sbjct: 586 ----NGVTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLS-HVCLPETCN 640

Query: 666 GRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILV-----TILCL 720
            +G+CNN+ +CHC   W+PP+C   G+GGS DSGP   +  +G+ + ++V      +  L
Sbjct: 641 MKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGP--ASAKRGVFLPLIVIPSLSVLTFL 698

Query: 721 LAAGFVVYLKR 731
              G ++YL++
Sbjct: 699 FTVGLLMYLRQ 709


>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
           [Homo sapiens]
          Length = 540

 Score =  351 bits (901), Expect = 2e-96
 Identities = 185/494 (37%), Positives = 271/494 (54%), Gaps = 32/494 (6%)

Query: 68  LNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRG 127
           L  ++    K  ++ L++N+ L+A  +TET+Y   G +++ +     I+  CYY GH+  
Sbjct: 57  LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQ---IMDDCYYQGHILN 113

Query: 128 YSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-------YKLFPAKKLKSVRGSCG 180
              S  S+STC GLRG     ++ Y +EP+ S  +R       +K  P +K  +   +CG
Sbjct: 114 EKVSDASISTCRGLRGYFSQGDQRYFIEPL-SPIHRDGQEHALFKYNPDEK--NYDSTCG 170

Query: 181 ------SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
                 +H    N+A       P+    +   R+  +  KY+E  +V DN EF+R  ++ 
Sbjct: 171 MDGVLWAHDLQQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQ 224

Query: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294
           +++++R+ E+AN+V+  Y+ LN  + LVG+E+W D DK  ++ +   +L  F  WR   L
Sbjct: 225 DEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVL 284

Query: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354
             RK HD AQL++     GTT+G+A + +MC+   S G+V DHSDN L  A T+AHE+GH
Sbjct: 285 SRRKRHDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGH 343

Query: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
           NFGM HD  D  C C   +    C+M+ +  +  P  FSSCSR   +   E  +  CLFN
Sbjct: 344 NFGMFHD--DYSCKCPSTI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397

Query: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474
            P   +      CGN+ VE GE+CDCG  EEC N CC+A TC +K    CA G CCE CQ
Sbjct: 398 APLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQ 457

Query: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534
            K AG  CR + + CDLPE C G S +CP + +  +G  C    G+C  G C T ++QC 
Sbjct: 458 FKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCT 517

Query: 535 TLWGPGAKPAPGIC 548
            LWGPG +  P  C
Sbjct: 518 ELWGPGRRTNPFPC 531


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score =  350 bits (897), Expect = 4e-96
 Identities = 228/713 (31%), Positives = 353/713 (49%), Gaps = 59/713 (8%)

Query: 46  SVGSGDLWIPVKSFDSKNH--PEVLNIR-------------LQRESKELIINLERNEGLI 90
           S+G   ++ P   FDS     PE L+ R             LQ + K+ +++L     L+
Sbjct: 25  SLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLL 84

Query: 91  ASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFEN 149
                   + + G    L  ++  I   C Y G V+   DS  ++STC  GLRG+   + 
Sbjct: 85  PRHLRVFSFTEHG---ELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDA 141

Query: 150 ESYVLEPMKSATN-RYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWAR-RHKR 207
           + Y +EP+K++ +  + ++  KK +     CG   +            P +  AR R   
Sbjct: 142 KHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMA-----PYENKARLRDFP 196

Query: 208 ETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVW 267
            + K  KY+EL+++ D   ++    +L +V    I +   +D +++ + +RI L  +EVW
Sbjct: 197 GSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVW 256

Query: 268 NDMDKCSVSQDPFTS-LHEFLDWRKMKLLPRKSHDNAQL-VSGVYFQGTTIGMAPIMSMC 325
            D +K  V        L  F+ ++K  L  R S D A L +   Y          +   C
Sbjct: 257 TDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKV---C 313

Query: 326 TADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNAS-T 384
           + + +G +      N L  A   AHELGH  GM+HD  ++ C C+  +    CIM +  T
Sbjct: 314 SLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD--EQYCQCRGRLN---CIMGSGRT 368

Query: 385 GYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPE 444
           G      FS+CS       +  G   CL N+P +   +  ++CGN+ VE+ EECDCG  E
Sbjct: 369 G------FSNCSYISFFKHISSG-ATCLNNIPGL--GYVLKRCGNKIVEDNEECDCGSTE 419

Query: 445 ECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPA 504
           EC    C  + C L+P A C+ GLCC DC+ +P+G  CR   N CDL E+C G S  CP 
Sbjct: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479

Query: 505 NVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGK 564
           +VY  DG  C+  +G C+   C++   QC +++GP A  AP  C++ VN  GD +GNC  
Sbjct: 480 DVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEI 538

Query: 565 VSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLG- 623
               +F KCE  ++ CG++QC    + P +  +   I T++   Q   ++C GT  +L  
Sbjct: 539 TGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHL---QAENLMCWGTGYHLSM 595

Query: 624 --DDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAH 681
               +PD G++  GT C +G++C  + C N SV        +C+ RGVCNNRKNCHC   
Sbjct: 596 KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYG 655

Query: 682 WAPPFCDKFGFGGSTDSGP---IRQADNQGLTIGILV---TILCLLAAGFVVY 728
           WAPPFC++ G+GGS DSGP   +R A    + +  ++    IL +L+  FV +
Sbjct: 656 WAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFF 708


>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
           sapiens]
          Length = 769

 Score =  340 bits (872), Expect = 4e-93
 Identities = 220/636 (34%), Positives = 308/636 (48%), Gaps = 54/636 (8%)

Query: 81  INLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSG 140
           ++LE N  L++S + E H+ ++GT     ++ T    HCYY G +RG   S  +LSTC G
Sbjct: 99  LDLELNHHLLSSQYVERHFSREGT----TQHSTGAGDHCYYQGKLRGNPHSFAALSTCQG 154

Query: 141 LRGLIVFENESYVLEPMKSATN--------RYKLFPAKKLKSVRG--SCGSHHNTPNLAA 190
           L G+    N +Y++EP + A           + ++    L    G    G     P  +A
Sbjct: 155 LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSA 214

Query: 191 KNVFPPPSQTWARRHKRETLKA-------TKYVELVIVADNREFQRQGKDLEKVKQRLIE 243
                PP++   RR KR+  +        TKYVEL+++ D++ F++  + +         
Sbjct: 215 -----PPNRPRLRR-KRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKS 268

Query: 244 IANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDN 302
           + N  D  Y+  LN RIVLV +E W D DK  V  D   +L   + +R+ + LP  S D 
Sbjct: 269 VVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRR-EGLPEPS-DA 326

Query: 303 AQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGM---N 359
             L SG  FQ T+ G A +  +C+    GG+  +   N    AVTLA  LG N GM    
Sbjct: 327 THLFSGRTFQSTSSGAAYVGGICSLSHGGGV--NEYGNMGAMAVTLAQTLGQNLGMMWNK 384

Query: 360 HDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVR 419
           H +    C C       GCIM   TG+  P  FS CS  +    L++G G CLFN P   
Sbjct: 385 HRSSAGDCKCPDIWL--GCIME-DTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKP--L 439

Query: 420 ESFGGQKCGNRFVEEGEECDCGEPEECMN---RCCNATTCTLKPDAVCAHGLCCEDCQLK 476
           +     +CGN FVE GEECDCG  +EC      CC    CTL  DA+C+ GLCC  C+ +
Sbjct: 440 KLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHDAMCSDGLCCRRCKYE 497

Query: 477 PAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTL 536
           P G +CR++ N CD+ E CTG S  CP N++  DG+ C    G CY G C+T ++QC  L
Sbjct: 498 PRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVL 557

Query: 537 WGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGT 596
           WG  A  A   C+E++N  G   G+CG+   S + +C  +D  CG + C   +  P +G 
Sbjct: 558 WGHAA--ADRFCYEKLNVEGTERGSCGR-KGSGWVQCSKQDVLCGFLLCVNISGAPRLGD 614

Query: 597 NAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFG 656
               I +     QG  + CRG HV L D   D   V  GT C    +CL+ +C   S F 
Sbjct: 615 LVGDISSVTFYHQGKELDCRGGHVQLADG-SDLSYVEDGTACGPNMLCLDHRCLPASAFN 673

Query: 657 VHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFC 687
              C        C   GVC+N   C C+  W    C
Sbjct: 674 FSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDC 709


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,457,834
Number of Sequences: 37866
Number of extensions: 2226228
Number of successful extensions: 9829
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 92
Number of HSP's successfully gapped in prelim test: 402
Number of HSP's that attempted gapping in prelim test: 7934
Number of HSP's gapped (non-prelim): 1782
length of query: 909
length of database: 18,247,518
effective HSP length: 111
effective length of query: 798
effective length of database: 14,044,392
effective search space: 11207424816
effective search space used: 11207424816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.