Search of human proteins with 69354859

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo
sapiens]
         (856 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]  1811   0.0  
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   522   e-148
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   512   e-145
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   506   e-143
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   494   e-139
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   462   e-130
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   432   e-121
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot...   404   e-112
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   400   e-111
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   400   e-111
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   400   e-111
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   400   e-111
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   399   e-111
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   398   e-110
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...   391   e-108
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   365   e-100
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   298   1e-80
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s...   293   4e-79
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   291   2e-78
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   291   2e-78
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   291   2e-78
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   291   2e-78
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   290   5e-78
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   290   5e-78
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   290   5e-78
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   286   6e-77
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...   286   6e-77
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...   278   2e-74
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   270   5e-72
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s...   264   2e-70

>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score = 1811 bits (4690), Expect = 0.0
 Identities = 856/856 (100%), Positives = 856/856 (100%)

Query: 1   MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYV 60
           MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYV
Sbjct: 1   MRGLGLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYV 60

Query: 61  LGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAAS 120
           LGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAAS
Sbjct: 61  LGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAAS 120

Query: 121 LSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGP 180
           LSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGP
Sbjct: 121 LSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGP 180

Query: 181 RTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKL 240
           RTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKL
Sbjct: 181 RTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKL 240

Query: 241 NFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTT 300
           NFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTT
Sbjct: 241 NFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTT 300

Query: 301 VGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAG 360
           VGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAG
Sbjct: 301 VGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAG 360

Query: 361 RCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGE 420
           RCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGE
Sbjct: 361 RCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGE 420

Query: 421 QCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCD 480
           QCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCD
Sbjct: 421 QCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCD 480

Query: 481 GRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCK 540
           GRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCK
Sbjct: 481 GRHPECPEDAFQENGTPCSGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCK 540

Query: 541 ASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKG 600
           ASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKG
Sbjct: 541 ASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKG 600

Query: 601 RCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVV 660
           RCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVV
Sbjct: 601 RCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVV 660

Query: 661 VLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPS 720
           VLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPS
Sbjct: 661 VLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPS 720

Query: 721 RGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFA 780
           RGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFA
Sbjct: 721 RGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFA 780

Query: 781 PPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAELPQHPRGAPAPVWKFGEVAAE 840
           PPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAELPQHPRGAPAPVWKFGEVAAE
Sbjct: 781 PPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAELPQHPRGAPAPVWKFGEVAAE 840

Query: 841 KPCVPAFHGPASAAQP 856
           KPCVPAFHGPASAAQP
Sbjct: 841 KPCVPAFHGPASAAQP 856


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  522 bits (1345), Expect = e-148
 Identities = 309/836 (36%), Positives = 424/836 (50%), Gaps = 107/836 (12%)

Query: 53  HPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQ---DHCFYQG 109
           HPE ++  L        ++L +N  L+ S +TET+   +G++V+          HC+Y G
Sbjct: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123

Query: 110 HVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGV 169
           HV GY DSA SLSTC+GLRG     ++ +++EP+       R+ ++ A+ L    G+CG 
Sbjct: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATN--RYKLFPAKKLKSVRGSCGS 181

Query: 170 SDDSLGSLLGPRTAA--VFRPRPGDSLPSRE-------TRYVELYVVVDNAEFQMLGSEA 220
             ++      P  AA  VF P P  +   R        T+YVEL +V DN EFQ  G + 
Sbjct: 182 HHNT------PNLAAKNVFPP-PSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234

Query: 221 A-VRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQR 279
             V+ R++E+ NHVDK Y+ LN R+VLVG+E+WN  D+  VS DP  +L   L W+  + 
Sbjct: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294

Query: 280 TRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGH 338
             R  HDN QL++GV F GTT+G A + +MC+   SG +  DHS NP+G A T+AHE+GH
Sbjct: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354

Query: 339 NLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLAN 398
           N GM+HD   +GC CQ   E G CIM  S G  FP +FS CS+  LE+ LE+   VCL N
Sbjct: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414

Query: 399 APDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECK 458
            P++    GG  CGN FVE GE+CDCG PE+C NRCCN+TTC L   A CAHG CC++C+
Sbjct: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474

Query: 459 VKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCS--GGYCYNGACPTLAQQCQ 516
           +KPAG  CR   + CDL EFC G  P CP + +  +G  C    GYCYNG C T  QQC 
Sbjct: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534

Query: 517 AFWGPGGQAAEESCF-----SYDILPGC----KASRYRADM----CGVLQCKGGQ----- 558
             WGPG + A   CF     + D    C    K+S  + +M    CG +QC+GG      
Sbjct: 535 TLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVI 594

Query: 559 -------------QPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDL 605
                        Q  GR +C     H    +D      V  GT+C   K+C   +CQ++
Sbjct: 595 GTNAVSIETNIPLQQGGRILC--RGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNI 652

Query: 606 HVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVF---VVVVL 662
            V+    C+ QCH  GVCN+++ CHC A WAPP C K        SG +       + + 
Sbjct: 653 SVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIG 712

Query: 663 VLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRG 722
           +L+ ++ +  AG +VY K ++ I       KTT+                K     PSR 
Sbjct: 713 ILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTI---------------EKLRCVRPSRP 757

Query: 723 PQELVP-TTHPGQPARHPASSVALKRPPPAPP------------VTVSSPPFPVPVYTRQ 769
           P+   P   H G    H    +  K P   PP            V +S P   + V   Q
Sbjct: 758 PRGFQPCQAHLG----HLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQ 813

Query: 770 APKQVIKPTFAPPVPPVKPGAGAANPGPAEGAVGPKVALKPPIQRKQGAELPQHPR 825
           + ++V+ P    P  P  P    A P PA          KP +++ QG   P  P+
Sbjct: 814 STQRVLPPLHRAPRAPSVP----ARPLPA----------KPALRQAQGTCKPNPPQ 855


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  512 bits (1319), Expect = e-145
 Identities = 328/919 (35%), Positives = 459/919 (49%), Gaps = 118/919 (12%)

Query: 16  AIAPSRPWALME--------------QYEVVLP-WRLPGPRVRRALPSHLGLHPERVSYV 60
           A+ P RP A  E              Q+E+++P W+     VR         HP +    
Sbjct: 16  ALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREK-------HPLKAELR 68

Query: 61  LGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAAS 120
           + A G    L L KN  L    YTET+  ++G+  T   + +DHCFY G V     S+ +
Sbjct: 69  VMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVT 128

Query: 121 LSTCAGLRGFFQVGSDL-HLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGS--- 176
           LSTC G+RG   V S+L ++IEPL +    G+H +Y++EHL    G CG       +   
Sbjct: 129 LSTCRGIRGLITVSSNLSYVIEPLPDSK--GQHLIYRSEHLKPPPGNCGFEHSKPTTRDW 186

Query: 177 LLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQM-LGSEAAVRHRVLEVVNHVDK 235
            L        RPR          +YVELY+V D  EFQ     + A +H+++E+ N+VDK
Sbjct: 187 ALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDK 246

Query: 236 LYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVD 295
            Y+ LN R+ LVGLE+W   +   VS +P  TL + L+W+ +   +++ HDN QLITG+ 
Sbjct: 247 FYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNAQLITGMS 305

Query: 296 FTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQ 354
           F GTT+G A + AMCS + SG VN DHS+N +GVA TMAHEMGHN GM HD     C C 
Sbjct: 306 FHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDS--ADC-CS 362

Query: 355 ERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNL 414
                G CIMA + G  FP++F+ C++  L+ +L+    +CL+N PD   L GG  CGN 
Sbjct: 363 ASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNG 422

Query: 415 FVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCD 474
           ++E GE+CDCG  E+C N CCN++ C L  GA+CAHG+CC +CK+   G LCR +   CD
Sbjct: 423 YLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCD 482

Query: 475 LEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAEESCF- 531
           L EFC G+ P CP + +Q +GTPC GG  YCYNG C T  +QCQ  WGPG + A + CF 
Sbjct: 483 LPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFE 542

Query: 532 ----SYDILPGC--------KASRYRADMCGVLQCKGGQ-QPL--------------GRA 564
               + D    C        +    R   CG +QC+  + +PL              GR 
Sbjct: 543 KVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQ 602

Query: 565 I-CIVDVCHALTTEDGTAYEP--VPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHG 621
           I C     +    E+G   +P  V  GT+CG   +C++G+C++   + +  C  +C+ HG
Sbjct: 603 IQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHG 662

Query: 622 VCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLP---VFVVVVLVLLAVVLVTLAGIIVY 678
           VCN+ Q CHC  GWAPP C          SG +P   V  VV  VL+A++++ +  ++ Y
Sbjct: 663 VCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYY 722

Query: 679 RKARSRILSR------------------NVAPKTTMGRSNPLFHQAASRVPAKG-GAPAP 719
              ++  L +                   V+  +  G +NP F     +   K    P  
Sbjct: 723 CCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEI 782

Query: 720 SRGPQELVPTTHP------GQPARHPA--SSVALKRPPPAPPV--TVSS----PPFPVPV 765
            R P +  P   P        PA  PA  S  A   P P   +  T SS    P  P+P 
Sbjct: 783 LRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIP- 841

Query: 766 YTRQAPKQVIKPTFAPPVPPVKPGAGAANPGPAEGAV---GPKVALKPPIQRKQGAELPQ 822
               AP  ++   F+ P PP K  A  ANP P   ++   G    L+PP     GA  PQ
Sbjct: 842 ---PAPNCIVSQDFSRPRPPQK--ALPANPVPGRRSLPRPGGASPLRPP-----GAG-PQ 890

Query: 823 HPRGAPAPVWKFGEVAAEK 841
             R   A   KF E  +++
Sbjct: 891 QSRPLAALAPKFPEYRSQR 909


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  506 bits (1302), Expect = e-143
 Identities = 264/637 (41%), Positives = 355/637 (55%), Gaps = 58/637 (9%)

Query: 53  HPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQ---DHCFYQG 109
           HPE ++  L        ++L +N  L+ S +TET+   +G++V+          HC+Y G
Sbjct: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123

Query: 110 HVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGV 169
           HV GY DSA SLSTC+GLRG     ++ +++EP+       R+ ++ A+ L    G+CG 
Sbjct: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATN--RYKLFPAKKLKSVRGSCGS 181

Query: 170 SDDSLGSLLGPRTAA--VFRPRPGDSLPSRE-------TRYVELYVVVDNAEFQMLGSEA 220
             ++      P  AA  VF P P  +   R        T+YVEL +V DN EFQ  G + 
Sbjct: 182 HHNT------PNLAAKNVFPP-PSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234

Query: 221 A-VRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQR 279
             V+ R++E+ NHVDK Y+ LN R+VLVG+E+WN  D+  VS DP  +L   L W+  + 
Sbjct: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294

Query: 280 TRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGH 338
             R  HDN QL++GV F GTT+G A + +MC+   SG +  DHS NP+G A T+AHE+GH
Sbjct: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354

Query: 339 NLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLAN 398
           N GM+HD   +GC CQ   E G CIM  S G  FP +FS CS+  LE+ LE+   VCL N
Sbjct: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414

Query: 399 APDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECK 458
            P++    GG  CGN FVE GE+CDCG PE+C NRCCN+TTC L   A CAHG CC++C+
Sbjct: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474

Query: 459 VKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCS--GGYCYNGACPTLAQQCQ 516
           +KPAG  CR   + CDL EFC G  P CP + +  +G  C    GYCYNG C T  QQC 
Sbjct: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534

Query: 517 AFWGPGGQAAEESCF-----SYDILPGC----KASRYRADM----CGVLQCKGGQ----- 558
             WGPG + A   CF     + D    C    K+S  + +M    CG +QC+GG      
Sbjct: 535 TLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVI 594

Query: 559 -------------QPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDL 605
                        Q  GR +C     H    +D      V  GT+C   K+C   +CQ++
Sbjct: 595 GTNAVSIETNIPLQQGGRILC--RGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNI 652

Query: 606 HVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAK 642
            V+    C+ QCH  GVCN+++ CHC A WAPP C K
Sbjct: 653 SVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDK 689


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  494 bits (1273), Expect = e-139
 Identities = 282/724 (38%), Positives = 394/724 (54%), Gaps = 52/724 (7%)

Query: 5   GLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRAL-PSHLGLHPERVSYVLGA 63
           GL  +  ++  A++  +    +++YEVV P RL     R A  P         + Y +  
Sbjct: 4   GLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTI 63

Query: 64  TGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLST 123
            G    L+L+KN++LL  GYTETY  + G E+T  P+  D C+YQGH+     S AS+ST
Sbjct: 64  NGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASIST 123

Query: 124 CAGLRGFFQVGSDLHLIEPLDE-GGEGGRHAVYQ----AEHLLQTAGTCGV--SDDSLGS 176
           C GLRG+F  G   + IEPL     +G  HA+++     ++   T G  GV  + D   +
Sbjct: 124 CRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQN 183

Query: 177 LLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLG-SEAAVRHRVLEVVNHVDK 235
           +  P T  V   +  D       +Y+E Y+V+DN EF+    ++  +R RV E+ N+V+ 
Sbjct: 184 IALPATKLV---KLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240

Query: 236 LYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVD 295
           LY+KLN  V LVG+EIW  +D+  ++P+ S TLEN   W+    +RR  HD  QLIT  +
Sbjct: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300

Query: 296 FTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQE 355
             GTTVG A +S MCS  S  V QDHS N + VA TMAHEMGHN GM HD+    C+C  
Sbjct: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD--YSCKCPS 358

Query: 356 RFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLF 415
                 C+M  ++    P  FS CS+   + F E   S CL NAP  + ++  P+CGN  
Sbjct: 359 TI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQL 414

Query: 416 VERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDL 475
           VE GE CDCG  E+C N CC++ TC++    QCA G CC++C+ K AG +CRP KD CDL
Sbjct: 415 VEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDL 474

Query: 476 EEFCDGRHPECPEDAFQENGTPC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSY 533
            E C+G+   CP+D FQ NG PC    G+C  G CPTL +QC   WGPG + A++SC++ 
Sbjct: 475 PEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNR 534

Query: 534 --------------DILPGCKASRYRADMCGVLQCKGGQQPL---GRAICIVDVCHALTT 576
                         D L  CKA+     MCG L C+GG   L   GR +  +  C     
Sbjct: 535 NEGGSKYGYCRRVDDTLIPCKAN---DTMCGKLFCQGGSDNLPWKGRIVTFL-TCKTFDP 590

Query: 577 EDGTAYE--PVPEGTRCGPEKVCWKGRCQDLH-VYRSSNCSAQCHNHGVCNHKQECHCHA 633
           ED T+ E   V  GT+CG  KVC    C D+   Y+S+NCS++C  H VC+H+ +C C  
Sbjct: 591 ED-TSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDHELQCQCEE 649

Query: 634 GWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPK 693
           GW PP C       H +       VV VL  +AV+ V +A +I ++ +R +   ++  P 
Sbjct: 650 GWIPPDCDDSSVVFHFS------IVVGVLFPMAVIFVVVAMVIRHQSSREK-QKKDQRPL 702

Query: 694 TTMG 697
           +T G
Sbjct: 703 STTG 706


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  462 bits (1189), Expect = e-130
 Identities = 293/787 (37%), Positives = 389/787 (49%), Gaps = 73/787 (9%)

Query: 6   LWLL-GAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGAT 64
           LW + GA +L    P +P        V   W L G   R          P+     L A 
Sbjct: 22  LWPVPGAGVLQGHIPGQP--------VTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73

Query: 65  GHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC 124
           G    L L KN  LL  GY ET+   +G  V   P   DHC YQG V G+PDS   L TC
Sbjct: 74  GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133

Query: 125 AGLRGFFQVGSDL-HLIEPLDEGG--EGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPR 181
           +G+ G   +  +  + + P    G  +   H +++ E LL   GTCG  D   G+  G  
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDP--GNKAG-M 190

Query: 182 TAAVFRPRPGDSLPSRETR-YVELYVVVDNAEFQMLGSEAAVRH---RVLEVVNHVDKLY 237
           T+    P+      +R TR Y+ELY+V D+  F  L     + H   R+LEV N+VD+L 
Sbjct: 191 TSLPGGPQSRGRREARRTRKYLELYIVADHTLF--LTRHRNLNHTKQRLLEVANYVDQLL 248

Query: 238 QKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFT 297
           + L+ +V L GLE+W  +DR  V+ D + TL   L W+     +R  HD+ QL+TG  F 
Sbjct: 249 RTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRP-HDSAQLLTGRAFQ 307

Query: 298 GTTVGFARVSAMC-SHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQER 356
           G TVG A V  MC + SSG V+ DHS+ P+G A TMAHE+GH+LG+ HD +  GC  +  
Sbjct: 308 GATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD--GCCVEAA 365

Query: 357 FEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFV 416
            E+G C+MA + G  FPR+FS CS+  L +F  +    CL+NAPD    V   +CGN FV
Sbjct: 366 AESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFV 425

Query: 417 ERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLE 476
           E GE+CDCGP ++CR+ CC +  C L  GAQCAHG CC  C +KPAG LCR     CDL 
Sbjct: 426 EAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLP 485

Query: 477 EFCDGRHPECPEDAFQENGTPCS--GGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSY- 533
           EFC G    CP D +  +G+PC+   GYC++GACPTL QQCQ  WGPG   A E+CF   
Sbjct: 486 EFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVV 545

Query: 534 ----DILPGCKASRY--------RADMCGVLQCKGGQQPLGRAICI-VDVCHALTTEDGT 580
               D    C             R  +CG LQC+GG+  L     + VD    L  ++ T
Sbjct: 546 NSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVT 605

Query: 581 AYEP---------------VPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNH 625
                              V  GT+CGP  VC   RC+         C   CH+HGVCN 
Sbjct: 606 CRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNS 665

Query: 626 KQECHCHAGWAPPHCAKLLTEVHAASGSL-----PVFVVVVLVLLAVVLVTLAGI--IVY 678
              CHC  GWAPP C K        SG +       F++ +L+ + + L+  AG+    Y
Sbjct: 666 NHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCY 725

Query: 679 RKARSRI------LSRNVA---PKTTMGRSNPLFHQAASRV-PAKGGAPAPSRGPQELVP 728
           R   + +        R+ A   PK    R +PL       + P   G P P        P
Sbjct: 726 RLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEP 785

Query: 729 TTHPGQP 735
           ++HP +P
Sbjct: 786 SSHPEKP 792


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  432 bits (1111), Expect = e-121
 Identities = 283/771 (36%), Positives = 377/771 (48%), Gaps = 67/771 (8%)

Query: 6   LWLL-GAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGAT 64
           LW + GA +L    P +P        V   W L G   R          P+     L A 
Sbjct: 22  LWPVPGAGVLQGHIPGQP--------VTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73

Query: 65  GHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC 124
           G    L L KN  LL  GY ET+   +G  V   P   DHC YQG V G+PDS   L TC
Sbjct: 74  GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133

Query: 125 AGLRGFFQVGSDL-HLIEPLDEGG--EGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPR 181
           +G+ G   +  +  + + P    G  +   H +++ E LL   GTCG  D   G+  G  
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDP--GNKAG-M 190

Query: 182 TAAVFRPRPGDSLPSRETR-YVELYVVVDNAEFQMLGSEAAVRH---RVLEVVNHVDKLY 237
           T+    P+      +R TR Y+ELY+V D+  F  L     + H   R+LEV N+VD+L 
Sbjct: 191 TSLPGGPQSRGRREARRTRKYLELYIVADHTLF--LTRHRNLNHTKQRLLEVANYVDQLL 248

Query: 238 QKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFT 297
           + L+ +V L GLE+W  +DR  V+ D + TL   L W+     +R  HD+ QL+TG  F 
Sbjct: 249 RTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRP-HDSAQLLTGRAFQ 307

Query: 298 GTTVGFARVSAMC-SHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQER 356
           G TVG A V  MC + SSG V+ DHS+ P+G A TMAHE+GH+LG+ HD +  GC  +  
Sbjct: 308 GATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD--GCCVEAA 365

Query: 357 FEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFV 416
            E+G C+MA + G  FPR+FS CS+  L +F  +    CL+NAPD    V   +CGN FV
Sbjct: 366 AESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFV 425

Query: 417 ERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLE 476
           E GE+CDCGP ++CR+ CC +  C L  GAQCAHG CC  C +KPAG LCR     CDL 
Sbjct: 426 EAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLP 485

Query: 477 EFCDGRHPECPEDAFQENGTPCS--GGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSY- 533
           EFC G    CP D +  +G+PC+   GYC++GACPTL QQCQ  WGPG   A E+CF   
Sbjct: 486 EFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVV 545

Query: 534 ----DILPGCKASRY--------RADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTA 581
               D    C             R  +CG LQC+GG+  L        +   +   D T 
Sbjct: 546 NSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSL--------LAPHMVPVDSTV 597

Query: 582 YEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCA 641
           +    E T  G   +       DL          QC    VCN    CHC  GWAPP C 
Sbjct: 598 HLDGQEVTCRGA--LALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCD 655

Query: 642 KLLTEVHAASGSL-----PVFVVVVLVLLAVVLVTLAGI--IVYRKARSRI------LSR 688
           K        SG +       F++ +L+ + + L+  AG+    YR   + +        R
Sbjct: 656 KPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRR 715

Query: 689 NVA---PKTTMGRSNPLFHQAASRV-PAKGGAPAPSRGPQELVPTTHPGQP 735
           + A   PK    R +PL       + P   G P P        P++HP +P
Sbjct: 716 DPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKP 766


>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
           [Homo sapiens]
          Length = 540

 Score =  404 bits (1039), Expect = e-112
 Identities = 219/537 (40%), Positives = 301/537 (56%), Gaps = 20/537 (3%)

Query: 5   GLWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRAL-PSHLGLHPERVSYVLGA 63
           GL  +  ++  A++  +    +++YEVV P RL     R A  P         + Y +  
Sbjct: 4   GLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTI 63

Query: 64  TGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLST 123
            G    L+L+KN++LL  GYTETY  + G E+T  P+  D C+YQGH+     S AS+ST
Sbjct: 64  NGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASIST 123

Query: 124 CAGLRGFFQVGSDLHLIEPLDE-GGEGGRHAVYQ----AEHLLQTAGTCGV--SDDSLGS 176
           C GLRG+F  G   + IEPL     +G  HA+++     ++   T G  GV  + D   +
Sbjct: 124 CRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQN 183

Query: 177 LLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLG-SEAAVRHRVLEVVNHVDK 235
           +  P T  V   +  D       +Y+E Y+V+DN EF+    ++  +R RV E+ N+V+ 
Sbjct: 184 IALPATKLV---KLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNM 240

Query: 236 LYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVD 295
           LY+KLN  V LVG+EIW  +D+  ++P+ S TLEN   W+    +RR  HD  QLIT  +
Sbjct: 241 LYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATE 300

Query: 296 FTGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQE 355
             GTTVG A +S MCS  S  V QDHS N + VA TMAHEMGHN GM HD+    C+C  
Sbjct: 301 LAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD--YSCKCPS 358

Query: 356 RFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLF 415
                 C+M  ++    P  FS CS+   + F E   S CL NAP  + ++  P+CGN  
Sbjct: 359 TI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQL 414

Query: 416 VERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDL 475
           VE GE CDCG  E+C N CC++ TC++    QCA G CC++C+ K AG +CRP KD CDL
Sbjct: 415 VEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDL 474

Query: 476 EEFCDGRHPECPEDAFQENGTPC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESC 530
            E C+G+   CP+D FQ NG PC    G+C  G CPTL +QC   WGPG +     C
Sbjct: 475 PEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPC 531


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  400 bits (1029), Expect = e-111
 Identities = 274/784 (34%), Positives = 381/784 (48%), Gaps = 66/784 (8%)

Query: 54  PERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEG 113
           PE +   L   G +  L L +NR+L+    T  +   +G+ V  +    ++C YQG V G
Sbjct: 66  PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125

Query: 114 YPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVS-DD 172
           Y  S  S+ TC+GLRG   +  +         G   G   + + + L     TC +S  +
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE 185

Query: 173 SLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNH 232
           S+ +   P      R          ET+ VEL +V D++E Q       + +R LEV   
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALL 245

Query: 233 VDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLIT 292
           +D  ++ LN RV LVGLE W  +D   +SP+P+VTLEN L W+      R  HD+ QL+T
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305

Query: 293 GVDFTGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGC 351
           G  F+G TVG A  +++CS   SG VN DHS + +GVA ++AHE+GH+LG+DHD     C
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365

Query: 352 RCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCL-ANAPDLSHLVGGPV 410
            C     A  CIM  S        FS+CS+  LE  L      CL    P L  +     
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAA--F 423

Query: 411 CGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCA-HGTCCQECKVKPAGELCRPK 469
           CGN+FVE GEQCDCG  +DC + CC+S TCQL  GAQCA  G CCQ C+++P+G  CRP 
Sbjct: 424 CGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPT 483

Query: 470 KDMCDLEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAE 527
           +  CDL EFC G   +CP D    +G PC+GG   C +G C + AQQCQ+ WGPG Q A 
Sbjct: 484 RGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAA 543

Query: 528 ESCFSY-----DILPGC---KASRY-----RADMCGVLQCKGGQ-QPLGRAIC-----IV 568
             C        +    C    +  Y     R  +CG LQC+ G+ QPL  +I       +
Sbjct: 544 PLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETI 603

Query: 569 DV------CHALTTEDGT-AYEPV--PEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHN 619
           DV      C  +  + G+   +P+    GT CGP  VC   RCQ + +  +  C ++CH 
Sbjct: 604 DVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHG 663

Query: 620 HGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYR 679
           HGVC+  + C+C  GWAPP C    T++ A S      ++ +LVLL  VLV L     YR
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCT---TQLKATSSLTTGLLLSLLVLL--VLVMLGASYWYR 718

Query: 680 KARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAP----SRGPQELVPTTHPGQP 735
               + L +   P           ++AA   P++   P      +RG ++    + P  P
Sbjct: 719 ARLHQRLCQLKGPTCQ--------YRAAQSGPSERPGPPQRALLARGTKQASALSFPAPP 770

Query: 736 ARH-PASSVA--------LKRPPPAPPVTVS----SPPFPVPVYTRQAPKQVIKPTFAPP 782
           +R  P   V+         K PPP  P+        P   +P      P  V+    APP
Sbjct: 771 SRPLPPDPVSKRLQSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 830

Query: 783 VPPV 786
            P V
Sbjct: 831 PPTV 834


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  400 bits (1028), Expect = e-111
 Identities = 277/783 (35%), Positives = 380/783 (48%), Gaps = 65/783 (8%)

Query: 54  PERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEG 113
           PE +   L   G +  L L +NR+L+    T  +   +G+ V  +    ++C YQG V G
Sbjct: 66  PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125

Query: 114 YPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVS-DD 172
           Y  S  S+ TC+GLRG   +  +         G   G   + + + L     TC +S  +
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE 185

Query: 173 SLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNH 232
           S+ +   P      R          ET+ VEL +V D++E Q       + +R LEV   
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALL 245

Query: 233 VDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLIT 292
           +D  ++ LN RV LVGLE W  +D   +SP+P+VTLEN L W+      R  HD+ QL+T
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305

Query: 293 GVDFTGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGC 351
           G  F+G TVG A  +++CS   SG VN DHS + +GVA ++AHE+GH+LG+DHD     C
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365

Query: 352 RCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCL-ANAPDLSHLVGGPV 410
            C     A  CIM  S        FS+CS+  LE  L      CL    P L  +     
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAA--F 423

Query: 411 CGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCA-HGTCCQECKVKPAGELCRPK 469
           CGN+FVE GEQCDCG  +DC + CC+S TCQL  GAQCA  G CCQ C+++P+G  CRP 
Sbjct: 424 CGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPT 483

Query: 470 KDMCDLEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAE 527
           +  CDL EFC G   +CP D    +G PC+GG   C +G C + AQQCQ+ WGPG Q A 
Sbjct: 484 RGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAA 543

Query: 528 ESCFSY-----DILPGC---KASRY-----RADMCGVLQCKGGQ-QPLGRAIC-----IV 568
             C        +    C    +  Y     R  +CG LQC+ G+ QPL  +I       +
Sbjct: 544 PLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETI 603

Query: 569 DV------CHALTTEDGT-AYEPV--PEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHN 619
           DV      C  +  + G+   +P+    GT CGP  VC   RCQ + +  +  C ++CH 
Sbjct: 604 DVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHG 663

Query: 620 HGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYR 679
           HGVC+  + C+C  GWAPP C    T++ A S      ++ +LVLL  VLV L     YR
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCT---TQLKATSSLTTGLLLSLLVLL--VLVMLGASYWYR 718

Query: 680 KARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAP----SRGPQ-ELV----PTT 730
               + L +   P           ++AA   P++   P      +RG + EL     P T
Sbjct: 719 ARLHQRLCQLKGPTCQ--------YRAAQSGPSERPGPPQRALLARGTKAELADRPNPPT 770

Query: 731 HP---GQPARHPASSVALKRPPPAPPVTVS----SPPFPVPVYTRQAPKQVIKPTFAPPV 783
            P       R P S    K PPP  P+        P   +P      P  V+    APP 
Sbjct: 771 RPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPP 830

Query: 784 PPV 786
           P V
Sbjct: 831 PTV 833


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  400 bits (1027), Expect = e-111
 Identities = 271/847 (31%), Positives = 395/847 (46%), Gaps = 109/847 (12%)

Query: 8   LLGAMMLPAIAPSRPW----ALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGA 63
           LL  ++ P +  +RP     + +  YE++ PWRL   R RR  P     + ++VSYV+ A
Sbjct: 18  LLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRL--TRERREAPRP---YSKQVSYVIQA 72

Query: 64  TGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLST 123
            G    +HL +N+DLL   +        G+ +T+ P  Q+HC Y+G+VEG  +S+ +LS 
Sbjct: 73  EGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSD 132

Query: 124 CAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLG---- 179
           C GLRG   + +  + IEPL +      H +Y+ + + +    CGVS+  +         
Sbjct: 133 CFGLRGLLHLENASYGIEPL-QNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEE 191

Query: 180 --PRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLG-SEAAVRHRVLEVVNHVDKL 236
             P +      R    LP  +TRYVEL++VVD   + M+G ++ AVR  ++ + N++D +
Sbjct: 192 EEPPSMTQLLRRRRAVLP--QTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSM 249

Query: 237 YQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDF 296
           Y  LN R+VLVGLEIW + +  ++       L N + W+ +    R  HD+ QL+    F
Sbjct: 250 YIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGF 309

Query: 297 TGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQE 355
            G T G A V  +CS S +G +N          A  +AHE+GHNLGM+HD+  + C C  
Sbjct: 310 -GGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDG-RDCSC-- 365

Query: 356 RFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLF 415
              A  CIM  + G+S  R FS CS    E         CL N P        P CGN  
Sbjct: 366 --GAKSCIM--NSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKL 421

Query: 416 VERGEQCDCGPPEDCR-NRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCD 474
           V+ GE+CDCG P++C  + CC  +TC+L   A+CA+G CC++C+  P G LCR K   CD
Sbjct: 422 VDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECD 481

Query: 475 LEEFCDGRHPECPEDAFQENGTPCSG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCF- 531
           + E+C+G    C  D F +NG PC     YCYNG C     QCQ  +G   +AA + CF 
Sbjct: 482 VPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFI 541

Query: 532 ----SYDILPGC--KASRYRA-----DMCGVLQCKGGQQ--PLGRAICIVDVCHALTTED 578
                 D    C    + Y+       +CG LQC+  Q+    G    I+      T   
Sbjct: 542 EVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCW 601

Query: 579 GTAYE---------PVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQ--CHNHGVCNHKQ 627
           G  ++          V EGT+CG  K+C   +C D  V  + +C  Q  CH HGVCN  +
Sbjct: 602 GVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVL-NYDCDVQKKCHGHGVCNSNK 660

Query: 628 ECHCHAGWAPPHC-----------AKLLTEVHAA--SGSLPVFVVVVLVLLAVVLVTLAG 674
            CHC  GWAPP+C                E++ A   G L  F ++V +++  + + +  
Sbjct: 661 NCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKR 720

Query: 675 IIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQ 734
             ++R                            S    K      S G  +  P+  PG 
Sbjct: 721 DQLWR----------------------------SYFRKKRSQTYESDGKNQANPSRQPGS 752

Query: 735 PARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAG--- 791
             RH    V+   PP   P+  +   F VP Y  + P+Q   P+  PP  P     G   
Sbjct: 753 VPRH----VSPVTPPREVPIYANR--FAVPTYAAKQPQQF--PSRPPPPQPKVSSQGNLI 804

Query: 792 AANPGPA 798
            A P PA
Sbjct: 805 PARPAPA 811


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  400 bits (1027), Expect = e-111
 Identities = 280/813 (34%), Positives = 388/813 (47%), Gaps = 68/813 (8%)

Query: 54  PERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEG 113
           PE +   L   G +  L L +NR+L+    T  +   +G+ V  +    ++C YQG V G
Sbjct: 66  PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125

Query: 114 YPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVS-DD 172
           Y  S  S+ TC+GLRG   +  +         G   G   + + + L     TC +S  +
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE 185

Query: 173 SLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNH 232
           S+ +   P      R          ET+ VEL +V D++E Q       + +R LEV   
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALL 245

Query: 233 VDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLIT 292
           +D  ++ LN RV LVGLE W  +D   +SP+P+VTLEN L W+      R  HD+ QL+T
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305

Query: 293 GVDFTGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGC 351
           G  F+G TVG A  +++CS   SG VN DHS + +GVA ++AHE+GH+LG+DHD     C
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365

Query: 352 RCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCL-ANAPDLSHLVGGPV 410
            C     A  CIM  S        FS+CS+  LE  L      CL    P L  +     
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAA--F 423

Query: 411 CGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCA-HGTCCQECKVKPAGELCRPK 469
           CGN+FVE GEQCDCG  +DC + CC+S TCQL  GAQCA  G CCQ C+++P+G  CRP 
Sbjct: 424 CGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPT 483

Query: 470 KDMCDLEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAE 527
           +  CDL EFC G   +CP D    +G PC+GG   C +G C + AQQCQ+ WGPG Q A 
Sbjct: 484 RGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAA 543

Query: 528 ESCFSY-----DILPGC---KASRY-----RADMCGVLQCKGGQ-QPLGRAIC-----IV 568
             C        +    C    +  Y     R  +CG LQC+ G+ QPL  +I       +
Sbjct: 544 PLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETI 603

Query: 569 DV------CHALTTEDGT-AYEPV--PEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHN 619
           DV      C  +  + G+   +P+    GT CGP  VC   RCQ + +  +  C ++CH 
Sbjct: 604 DVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHG 663

Query: 620 HGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYR 679
           HGVC+  + C+C  GWAPP C    T++ A S      ++ +LVLL  VLV L     YR
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCT---TQLKATSSLTTGLLLSLLVLL--VLVMLGASYWYR 718

Query: 680 KARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAP----SRGPQELVPTTHPGQP 735
               + L +   P           ++AA   P++   P      +RG ++    + P  P
Sbjct: 719 ARLHQRLCQLKGPTCQ--------YRAAQSGPSERPGPPQRALLARGTKQASALSFPAPP 770

Query: 736 ARHPASSVALKR------PPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKP- 788
           +R        KR        P PP    + P P     R    Q      A P PP KP 
Sbjct: 771 SRPLPPDPVSKRLQAELADRPNPP----TRPLPADPVVRSPKSQ----GPAKPPPPRKPL 822

Query: 789 GAGAANPGPAEGAVGPKVALKPPIQRKQGAELP 821
            A      P+    GP   + P +   + A  P
Sbjct: 823 PADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPP 855


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  399 bits (1025), Expect = e-111
 Identities = 283/812 (34%), Positives = 390/812 (48%), Gaps = 89/812 (10%)

Query: 54  PERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEG 113
           PE +   L   G +  L L +NR+L+    T  +   +G+ V  +    ++C YQG V G
Sbjct: 66  PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125

Query: 114 YPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVS-DD 172
           Y  S  S+ TC+GLRG   +  +         G   G   + + + L     TC +S  +
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE 185

Query: 173 SLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNH 232
           S+ +   P      R          ET+ VEL +V D++E Q       + +R LEV   
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALL 245

Query: 233 VDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLIT 292
           +D  ++ LN RV LVGLE W  +D   +SP+P+VTLEN L W+      R  HD+ QL+T
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305

Query: 293 GVDFTGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGC 351
           G  F+G TVG A  +++CS   SG VN DHS + +GVA ++AHE+GH+LG+DHD     C
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365

Query: 352 RCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCL-ANAPDLSHLVGGPV 410
            C     A  CIM  S        FS+CS+  LE  L      CL    P L  +     
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAA--F 423

Query: 411 CGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCA-HGTCCQECKVKPAGELCRPK 469
           CGN+FVE GEQCDCG  +DC + CC+S TCQL  GAQCA  G CCQ C+++P+G  CRP 
Sbjct: 424 CGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPT 483

Query: 470 KDMCDLEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAE 527
           +  CDL EFC G   +CP D    +G PC+GG   C +G C + AQQCQ+ WGPG Q A 
Sbjct: 484 RGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAA 543

Query: 528 ESCFSY-----DILPGC---KASRY-----RADMCGVLQCKGGQ-QPLGRAIC-----IV 568
             C        +    C    +  Y     R  +CG LQC+ G+ QPL  +I       +
Sbjct: 544 PLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETI 603

Query: 569 DV------CHALTTEDGT-AYEPV--PEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHN 619
           DV      C  +  + G+   +P+    GT CGP  VC   RCQ + +  +  C ++CH 
Sbjct: 604 DVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHG 663

Query: 620 HGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYR 679
           HGVC+  + C+C  GWAPP C    T++ A S      ++ +LVLL +V++   G   + 
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCT---TQLKATSSLTTGLLLSLLVLLVLVML---GASYWY 717

Query: 680 KARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARH- 738
           +AR                     HQ   ++  KG  P       +  P+  PG P R  
Sbjct: 718 RAR--------------------LHQRLCQL--KG--PTCQYRAAQSGPSERPGPPQRAL 753

Query: 739 -PASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANP-- 795
               + A     PAPP   S P  P PV  R   +   +P   PP  P+       +P  
Sbjct: 754 LARGTKASALSFPAPP---SRPLPPDPVSKRLQAELADRPN--PPTRPLPADPVVRSPKS 808

Query: 796 -GPAEGAVGPKVALKPPIQRKQGAELPQHPRG 826
            GPA          KPP  RK    LP  P+G
Sbjct: 809 QGPA----------KPPPPRK---PLPADPQG 827


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  398 bits (1023), Expect = e-110
 Identities = 271/767 (35%), Positives = 376/767 (49%), Gaps = 57/767 (7%)

Query: 54  PERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEG 113
           PE +   L   G +  L L +NR+L+    T  +   +G+ V  +    ++C YQG V G
Sbjct: 66  PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125

Query: 114 YPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVS-DD 172
           Y  S  S+ TC+GLRG   +  +         G   G   + + + L     TC +S  +
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE 185

Query: 173 SLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNH 232
           S+ +   P      R          ET+ VEL +V D++E Q       + +R LEV   
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALL 245

Query: 233 VDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLIT 292
           +D  ++ LN RV LVGLE W  +D   +SP+P+VTLEN L W+      R  HD+ QL+T
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305

Query: 293 GVDFTGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGC 351
           G  F+G TVG A  +++CS   SG VN DHS + +GVA ++AHE+GH+LG+DHD     C
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365

Query: 352 RCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCL-ANAPDLSHLVGGPV 410
            C     A  CIM  S        FS+CS+  LE  L      CL    P L  +     
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAA--F 423

Query: 411 CGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCA-HGTCCQECKVKPAGELCRPK 469
           CGN+FVE GEQCDCG  +DC + CC+S TCQL  GAQCA  G CCQ C+++P+G  CRP 
Sbjct: 424 CGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPT 483

Query: 470 KDMCDLEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAE 527
           +  CDL EFC G   +CP D    +G PC+GG   C +G C + AQQCQ+ WGPG Q A 
Sbjct: 484 RGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAA 543

Query: 528 ESCFSY-----DILPGC---KASRY-----RADMCGVLQCKGGQ-QPLGRAIC-----IV 568
             C        +    C    +  Y     R  +CG LQC+ G+ QPL  +I       +
Sbjct: 544 PLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETI 603

Query: 569 DV------CHALTTEDGT-AYEPV--PEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHN 619
           DV      C  +  + G+   +P+    GT CGP  VC   RCQ + +  +  C ++CH 
Sbjct: 604 DVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHG 663

Query: 620 HGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYR 679
           HGVC+  + C+C  GWAPP C    T++ A S      ++ +LVLL  VLV L     YR
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCT---TQLKATSSLTTGLLLSLLVLL--VLVMLGASYWYR 718

Query: 680 KARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHP 739
               + L +   P           ++AA   P++   P     PQ  +     G  ++ P
Sbjct: 719 ARLHQRLCQLKGPTCQ--------YRAAQSGPSERPGP-----PQRALLAR--GTKSQGP 763

Query: 740 ASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPV 786
           A     ++P PA P     P   +P      P  V+    APP P V
Sbjct: 764 AKPPPPRKPLPADP-QGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTV 809


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score =  391 bits (1005), Expect = e-108
 Identities = 242/651 (37%), Positives = 337/651 (51%), Gaps = 39/651 (5%)

Query: 54  PERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEG 113
           PE +   L   G +  L L +NR+L+    T  +   +G+ V  +    ++C YQG V G
Sbjct: 66  PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125

Query: 114 YPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVS-DD 172
           Y  S  S+ TC+GLRG   +  +         G   G   + + + L     TC +S  +
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE 185

Query: 173 SLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNH 232
           S+ +   P      R          ET+ VEL +V D++E Q       + +R LEV   
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALL 245

Query: 233 VDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLIT 292
           +D  ++ LN RV LVGLE W  +D   +SP+P+VTLEN L W+      R  HD+ QL+T
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305

Query: 293 GVDFTGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGC 351
           G  F+G TVG A  +++CS   SG VN DHS + +GVA ++AHE+GH+LG+DHD     C
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365

Query: 352 RCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCL-ANAPDLSHLVGGPV 410
            C     A  CIM  S        FS+CS+  LE  L      CL    P L  +     
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAA--F 423

Query: 411 CGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCA-HGTCCQECKVKPAGELCRPK 469
           CGN+FVE GEQCDCG  +DC + CC+S TCQL  GAQCA  G CCQ C+++P+G  CRP 
Sbjct: 424 CGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPT 483

Query: 470 KDMCDLEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAE 527
           +  CDL EFC G   +CP D    +G PC+GG   C +G C + AQQCQ+ WGPG Q A 
Sbjct: 484 RGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAA 543

Query: 528 ESCFSY-----DILPGC---KASRY-----RADMCGVLQCKGGQ-QPLGRAIC-----IV 568
             C        +    C    +  Y     R  +CG LQC+ G+ QPL  +I       +
Sbjct: 544 PLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETI 603

Query: 569 DV------CHALTTEDGT-AYEPV--PEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHN 619
           DV      C  +  + G+   +P+    GT CGP  VC   RCQ + +  +  C ++CH 
Sbjct: 604 DVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHG 663

Query: 620 HGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLV 670
           HGVC+  + C+C  GWAPP C    T++ A S      ++ +LVLL +V++
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCT---TQLKATSSLTTGLLLSLLVLLVLVML 711


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  365 bits (937), Expect = e-100
 Identities = 236/715 (33%), Positives = 352/715 (49%), Gaps = 65/715 (9%)

Query: 26  MEQYEVVLPWRLPGPRVRRALPSH----LGLHPERVSYVLGATGHNFTLHLRKNRDLLGS 81
           +E  ++V P +LP  + R    +H    L  + E + Y +        LHL ++R+ LGS
Sbjct: 24  VEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGS 83

Query: 82  GYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIE 141
            Y+ET+ +  G   T  P+  DHCFYQG +    DSAAS+STC GLRGFF++    +LIE
Sbjct: 84  NYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIE 143

Query: 142 PLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETR- 200
           P+    EG  H V++    +        ++ +             +  PGD+    +++ 
Sbjct: 144 PVKYSDEG-EHLVFKYNLRVPYGANYSCTELNFTR----------KTVPGDNESEEDSKI 192

Query: 201 -------YVELYVVVDNAEFQMLGS-EAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIW 252
                  YVEL++V D+  ++  G     +R+R+  +VN V+ +Y+ LN  V LVG+EIW
Sbjct: 193 KGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIW 252

Query: 253 NSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMC-S 311
             +D+  +  +   TL     WQ +    R   D+V L++G        G +    MC  
Sbjct: 253 THEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQGISYPGGMCLP 312

Query: 312 HSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSS 371
           + S ++ +D   +   +A  MAH++GHNLGM HDE    C C     +G+C+M  S GS 
Sbjct: 313 YYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFP--CTCP----SGKCVM-DSDGSI 365

Query: 372 FPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCR 431
               FS CSQ     +L+  +  C+ N P   +      CGN  ++ GE+CDCGP ++C 
Sbjct: 366 PALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECT 425

Query: 432 NRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAF 491
           N CC++ TC L  G  CA G CC+ C++K AG +CRP KD CD  E C G  P CP+D F
Sbjct: 426 NPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQF 485

Query: 492 QENGTPC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPG----CKASRYR 545
           + NG PC  S GYC+ G CPT   QC   +      + + C+  +        CK    R
Sbjct: 486 RVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYCKNKENR 545

Query: 546 ------ADM-CGVLQCKGGQ--QPLG--RAICIVDVCHALTTE--------DGTAYEPVP 586
                  D+ CG + C GG+    LG  +   + D     T +        D T    V 
Sbjct: 546 FLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTDIGLVA 605

Query: 587 EGTRCGPEKVCWKGRCQDLH-VYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLT 645
            GT+CG   VC  G C ++  VY S+NC +QC+ + V  H  +CHC  G AP  C + L 
Sbjct: 606 SGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVACEETL- 664

Query: 646 EVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSN 700
             H  + ++   +VVVLVL+ V +  L  ++ YRK   ++      P  T+G  N
Sbjct: 665 --HVTNITI---LVVVLVLVIVGIGVLILLVRYRKC-IKLKQVQSPPTETLGVEN 713


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  298 bits (763), Expect = 1e-80
 Identities = 213/668 (31%), Positives = 315/668 (47%), Gaps = 54/668 (8%)

Query: 6   LWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATG 65
           LW    + +   + +RP       EVV+P ++   R R A        P  +SY L   G
Sbjct: 67  LWFGMFLSISGHSQARPSQYFTSPEVVIPLKVIS-RGRGAKA------PGWLSYSLRFGG 119

Query: 66  HNFTLHLRKNRDLLGSGYTE-TYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC 124
             + +H+R N+ L  +     TYT  +   + +QP  QD C+Y G+VEG P+S  +LSTC
Sbjct: 120 QRYIVHMRVNKLLFAAHLPVFTYTEQHAL-LQDQPFIQDDCYYHGYVEGVPESLVALSTC 178

Query: 125 AG-LRGFFQVGSDLHLIEPLDEGGEGGRHAVYQ--AEHLLQTAGTCGVSDDSLGSLLGPR 181
           +G   G  Q+   ++ I+P+        H VY+  ++        CG++++ +   +  +
Sbjct: 179 SGGFLGMLQINDLVYEIKPISVSATF-EHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQ 237

Query: 182 TAAVFRPRPGDSLPS-RETRYVELYVVVDNAEFQMLGSEAA-VRHRVLEVVNHVDKLYQK 239
            +  F  +    +      R+VEL VVVDN  +    S A  V+H V  VVN VD  Y  
Sbjct: 238 LSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHP 297

Query: 240 LNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGT 299
           L   V+L G++IW + +    S D    LE+   W+      R  HD   L    D  G 
Sbjct: 298 LEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIK-DTQGM 356

Query: 300 TVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFE 358
            +G A V  +C +  +  V+       V  A T+ HE+GHNLGM HD   Q C C+ ++ 
Sbjct: 357 KLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHD--TQWCVCELQW- 413

Query: 359 AGRCIMAGSIGSSFPRMFSDCSQA-YLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVE 417
              CIM           FS+CS A Y +S +     +C+   P   ++     CGNL VE
Sbjct: 414 ---CIMHAY--RKVTTKFSNCSYAQYWDSTIS--SGLCIQPPPYPGNIFRLKYCGNLVVE 466

Query: 418 RGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEE 477
            GE+CDCG    C    C    C L  GA CA G CC++CK  P+G LCR +   CDL E
Sbjct: 467 EGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPE 526

Query: 478 FCDGRHPECPEDAFQENGTPCS-GGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDIL 536
           +C+G   +CP+D + ++G  C+   +CY   C     QC+  +G   ++A +SC+     
Sbjct: 527 WCNGTSHQCPDDVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINT 586

Query: 537 PGCKASR-----------YRAD-MCGVLQCKG-GQQPLGRAICIVDVCHAL-TTEDGTAY 582
            G +              +  D MCG +QC+  G  P       V   H   TT  GT Y
Sbjct: 587 QGNRFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDY 646

Query: 583 E---------PVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQ-CHNHGVCNHKQECHCH 632
                      V +GT CGPEK+C + +C  + V+ S  C  + C+  G+CN+KQ CHC+
Sbjct: 647 HLGMAIPDIGEVKDGTVCGPEKICIRKKCASM-VHLSQACQPKTCNMRGICNNKQHCHCN 705

Query: 633 AGWAPPHC 640
             WAPP+C
Sbjct: 706 HEWAPPYC 713


>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
           sapiens]
          Length = 769

 Score =  293 bits (751), Expect = 4e-79
 Identities = 209/654 (31%), Positives = 290/654 (44%), Gaps = 66/654 (10%)

Query: 41  RVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPR 100
           RVR+  P    +H  +VS+V+ A   NFTL L  N  LL S Y E + +  G+       
Sbjct: 70  RVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGA 129

Query: 101 GQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGR------HAV 154
           G DHC+YQG + G P S A+LSTC GL G F  G+  +++EP +  G  G       H +
Sbjct: 130 G-DHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLI 188

Query: 155 YQAEHLLQTAGT----CGVSDDSLGSLLG-PRTAAVFRPRPGDSLPSRETRYVELYVVVD 209
           Y+   L    G     C  +  +  +    PR     + R G      ET+YVEL V+ D
Sbjct: 189 YRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVIND 248

Query: 210 NAEF-QMLGSEAAVRHRVLEVVNHVDKLY-QKLNFRVVLVGLEIWNSQDRFHVSPDPSVT 267
           +  F QM  S     +    VVN  D +Y ++LN R+VLV +E W   D+  V  D   T
Sbjct: 249 HQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLET 308

Query: 268 LENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVG 327
           L  L+ +  R+       D   L +G  F  T+ G A V  +CS S G    ++  N   
Sbjct: 309 LARLMVY--RREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYG-NMGA 365

Query: 328 VACTMAHEMGHNLGM---DHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYL 384
           +A T+A  +G NLGM    H  +   C+C + +    CIM  + G   PR FS CS    
Sbjct: 366 MAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDT-GFYLPRKFSRCSIDEY 422

Query: 385 ESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRN---RCCNSTTCQ 441
             FL+     CL N P    L+  P CGN FVE GE+CDCG  ++C      CC    C 
Sbjct: 423 NQFLQEGGGSCLFNKP--LKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKK--CT 478

Query: 442 LAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPC--S 499
           L   A C+ G CC+ CK +P G  CR   + CD+ E C G   +CP +  + +G  C   
Sbjct: 479 LTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHE 538

Query: 500 GGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKGGQQ 559
            G CY G C T  +QCQ  WG    AA+  C+    + G +         G +QC     
Sbjct: 539 QGRCYGGRCKTRDRQCQVLWGHA--AADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDV 596

Query: 560 PLGRAICI-----------------VDVCHA----------LTTEDGTAYEPVPEGTRCG 592
             G  +C+                 V   H           +   DG+    V +GT CG
Sbjct: 597 LCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACG 656

Query: 593 PEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCA 641
           P  +C   RC     +  S C        C +HGVC+++ +C C   W    C+
Sbjct: 657 PNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCS 710



 Score = 31.6 bits (70), Expect = 3.3
 Identities = 19/79 (24%), Positives = 32/79 (40%), Gaps = 1/79 (1%)

Query: 689 NVAPKTTMGRSNPLFHQAASRVPAKGGAPAPS-RGPQELVPTTHPGQPARHPASSVALKR 747
           ++ P   +G   P        +P  GG  AP    P  LV  +  G+  +    +   + 
Sbjct: 15  SLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQE 74

Query: 748 PPPAPPVTVSSPPFPVPVY 766
           PP  PPV ++   F +P +
Sbjct: 75  PPGGPPVHLAQVSFVIPAF 93


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  291 bits (744), Expect = 2e-78
 Identities = 229/802 (28%), Positives = 359/802 (44%), Gaps = 96/802 (11%)

Query: 30  EVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTA 89
           +VV+P R+ G   R   P      P  +SY+L   G    +H+ K + LL S +   +T 
Sbjct: 32  DVVIPVRITGT-TRGMTP------PGWLSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTY 83

Query: 90  AN-GSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC-AGLRGFFQVGSDLHLIEPLDEGG 147
            + G+ + +QP  Q++C+Y G+VEG P+S  SLSTC  G +G  Q+    + I+PL    
Sbjct: 84  TDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPL-AFS 142

Query: 148 EGGRHAVYQAEH-----------LLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS 196
               H VY+ +             +Q   TC +  + + +    +++ V     G  +  
Sbjct: 143 TTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYV-----GWWI-- 195

Query: 197 RETRYVELYVVVDNAEF-QMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQ 255
              R VE+ VV+DN  + +   +++ +   +  +VN VD +   +  +V+L GLEIW ++
Sbjct: 196 -HFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNK 254

Query: 256 DRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSS 314
           +   V  D   ++     W++   T R  HD   L T +   G + G      MC+ H S
Sbjct: 255 NLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRS 312

Query: 315 GAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPR 374
            A+    +K     +  +AH +GHNLGM+HDE+   CRC +     RCIM    G+    
Sbjct: 313 CAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT--CRCSQ----PRCIM--HEGNPPIT 364

Query: 375 MFSDCSQA-YLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNR 433
            FS+CS   + E  +ER +  CL        +     CGN  VE GE+CDCGP + C   
Sbjct: 365 KFSNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKD 422

Query: 434 CCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQE 493
            C  + C L +G+ CA G CC++CK  P+G++CR + + CDL E+C+G   +CP+D + E
Sbjct: 423 PCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVE 482

Query: 494 NGTPC-SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVL 552
           +G PC   GYCY  +C    +QC+  +G G   A E+C+      G +           +
Sbjct: 483 DGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYI 542

Query: 553 QCKGGQQPLGRAIC-----IVDVCHALTTE------------------DGTAYEPVPEGT 589
           +C       GR  C     I ++    T                     G     V +GT
Sbjct: 543 KCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGT 602

Query: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHA 649
            CG + +C    C  + +  S+   A C+  G+CN+K  CHC+  W PP+C         
Sbjct: 603 ECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV 662

Query: 650 ASGSLP------VFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLF 703
            SG  P       F  + ++LL V+ + L    +YR  +               +S P+ 
Sbjct: 663 DSGPPPKRKKKKKFCYLCILLLIVLFILLC--CLYRLCK---------------KSKPIK 705

Query: 704 HQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPV 763
            Q   + P+        R P EL P +   QP   P+ S     P  + P  + S   P 
Sbjct: 706 KQQDVQTPSAKEEEKIQRRPHELPPQS---QPWVMPSQSQPPVTPSQSHPQVMPSQSQP- 761

Query: 764 PVYTRQAPKQVIKPTFAPPVPP 785
           PV   Q+  +V+     PPV P
Sbjct: 762 PVTPSQSQPRVMPSQSQPPVMP 783


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  291 bits (744), Expect = 2e-78
 Identities = 229/802 (28%), Positives = 359/802 (44%), Gaps = 96/802 (11%)

Query: 30  EVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTA 89
           +VV+P R+ G   R   P      P  +SY+L   G    +H+ K + LL S +   +T 
Sbjct: 32  DVVIPVRITGT-TRGMTP------PGWLSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTY 83

Query: 90  AN-GSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC-AGLRGFFQVGSDLHLIEPLDEGG 147
            + G+ + +QP  Q++C+Y G+VEG P+S  SLSTC  G +G  Q+    + I+PL    
Sbjct: 84  TDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPL-AFS 142

Query: 148 EGGRHAVYQAEH-----------LLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS 196
               H VY+ +             +Q   TC +  + + +    +++ V     G  +  
Sbjct: 143 TTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYV-----GWWI-- 195

Query: 197 RETRYVELYVVVDNAEF-QMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQ 255
              R VE+ VV+DN  + +   +++ +   +  +VN VD +   +  +V+L GLEIW ++
Sbjct: 196 -HFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNK 254

Query: 256 DRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSS 314
           +   V  D   ++     W++   T R  HD   L T +   G + G      MC+ H S
Sbjct: 255 NLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRS 312

Query: 315 GAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPR 374
            A+    +K     +  +AH +GHNLGM+HDE+   CRC +     RCIM    G+    
Sbjct: 313 CAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT--CRCSQ----PRCIM--HEGNPPIT 364

Query: 375 MFSDCSQA-YLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNR 433
            FS+CS   + E  +ER +  CL        +     CGN  VE GE+CDCGP + C   
Sbjct: 365 KFSNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKD 422

Query: 434 CCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQE 493
            C  + C L +G+ CA G CC++CK  P+G++CR + + CDL E+C+G   +CP+D + E
Sbjct: 423 PCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVE 482

Query: 494 NGTPC-SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVL 552
           +G PC   GYCY  +C    +QC+  +G G   A E+C+      G +           +
Sbjct: 483 DGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYI 542

Query: 553 QCKGGQQPLGRAIC-----IVDVCHALTTE------------------DGTAYEPVPEGT 589
           +C       GR  C     I ++    T                     G     V +GT
Sbjct: 543 KCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGT 602

Query: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHA 649
            CG + +C    C  + +  S+   A C+  G+CN+K  CHC+  W PP+C         
Sbjct: 603 ECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV 662

Query: 650 ASGSLP------VFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLF 703
            SG  P       F  + ++LL V+ + L    +YR  +               +S P+ 
Sbjct: 663 DSGPPPKRKKKKKFCYLCILLLIVLFILLC--CLYRLCK---------------KSKPIK 705

Query: 704 HQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPV 763
            Q   + P+        R P EL P +   QP   P+ S     P  + P  + S   P 
Sbjct: 706 KQQDVQTPSAKEEEKIQRRPHELPPQS---QPWVMPSQSQPPVTPSQSHPQVMPSQSQP- 761

Query: 764 PVYTRQAPKQVIKPTFAPPVPP 785
           PV   Q+  +V+     PPV P
Sbjct: 762 PVTPSQSQPRVMPSQSQPPVMP 783


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  291 bits (744), Expect = 2e-78
 Identities = 229/802 (28%), Positives = 359/802 (44%), Gaps = 96/802 (11%)

Query: 30  EVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTA 89
           +VV+P R+ G   R   P      P  +SY+L   G    +H+ K + LL S +   +T 
Sbjct: 32  DVVIPVRITGT-TRGMTP------PGWLSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTY 83

Query: 90  AN-GSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC-AGLRGFFQVGSDLHLIEPLDEGG 147
            + G+ + +QP  Q++C+Y G+VEG P+S  SLSTC  G +G  Q+    + I+PL    
Sbjct: 84  TDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPL-AFS 142

Query: 148 EGGRHAVYQAEH-----------LLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS 196
               H VY+ +             +Q   TC +  + + +    +++ V     G  +  
Sbjct: 143 TTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYV-----GWWI-- 195

Query: 197 RETRYVELYVVVDNAEF-QMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQ 255
              R VE+ VV+DN  + +   +++ +   +  +VN VD +   +  +V+L GLEIW ++
Sbjct: 196 -HFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNK 254

Query: 256 DRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSS 314
           +   V  D   ++     W++   T R  HD   L T +   G + G      MC+ H S
Sbjct: 255 NLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRS 312

Query: 315 GAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPR 374
            A+    +K     +  +AH +GHNLGM+HDE+   CRC +     RCIM    G+    
Sbjct: 313 CAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT--CRCSQ----PRCIM--HEGNPPIT 364

Query: 375 MFSDCSQA-YLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNR 433
            FS+CS   + E  +ER +  CL        +     CGN  VE GE+CDCGP + C   
Sbjct: 365 KFSNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKD 422

Query: 434 CCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQE 493
            C  + C L +G+ CA G CC++CK  P+G++CR + + CDL E+C+G   +CP+D + E
Sbjct: 423 PCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVE 482

Query: 494 NGTPC-SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVL 552
           +G PC   GYCY  +C    +QC+  +G G   A E+C+      G +           +
Sbjct: 483 DGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYI 542

Query: 553 QCKGGQQPLGRAIC-----IVDVCHALTTE------------------DGTAYEPVPEGT 589
           +C       GR  C     I ++    T                     G     V +GT
Sbjct: 543 KCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGT 602

Query: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHA 649
            CG + +C    C  + +  S+   A C+  G+CN+K  CHC+  W PP+C         
Sbjct: 603 ECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV 662

Query: 650 ASGSLP------VFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLF 703
            SG  P       F  + ++LL V+ + L    +YR  +               +S P+ 
Sbjct: 663 DSGPPPKRKKKKKFCYLCILLLIVLFILLC--CLYRLCK---------------KSKPIK 705

Query: 704 HQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPV 763
            Q   + P+        R P EL P +   QP   P+ S     P  + P  + S   P 
Sbjct: 706 KQQDVQTPSAKEEEKIQRRPHELPPQS---QPWVMPSQSQPPVTPSQSHPQVMPSQSQP- 761

Query: 764 PVYTRQAPKQVIKPTFAPPVPP 785
           PV   Q+  +V+     PPV P
Sbjct: 762 PVTPSQSQPRVMPSQSQPPVMP 783


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  291 bits (744), Expect = 2e-78
 Identities = 229/802 (28%), Positives = 359/802 (44%), Gaps = 96/802 (11%)

Query: 30  EVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTA 89
           +VV+P R+ G   R   P      P  +SY+L   G    +H+ K + LL S +   +T 
Sbjct: 32  DVVIPVRITGT-TRGMTP------PGWLSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTY 83

Query: 90  AN-GSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC-AGLRGFFQVGSDLHLIEPLDEGG 147
            + G+ + +QP  Q++C+Y G+VEG P+S  SLSTC  G +G  Q+    + I+PL    
Sbjct: 84  TDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPL-AFS 142

Query: 148 EGGRHAVYQAEH-----------LLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS 196
               H VY+ +             +Q   TC +  + + +    +++ V     G  +  
Sbjct: 143 TTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEIDNSTQKQSSYV-----GWWI-- 195

Query: 197 RETRYVELYVVVDNAEF-QMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQ 255
              R VE+ VV+DN  + +   +++ +   +  +VN VD +   +  +V+L GLEIW ++
Sbjct: 196 -HFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNK 254

Query: 256 DRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSS 314
           +   V  D   ++     W++   T R  HD   L T +   G + G      MC+ H S
Sbjct: 255 NLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRS 312

Query: 315 GAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPR 374
            A+    +K     +  +AH +GHNLGM+HDE+   CRC +     RCIM    G+    
Sbjct: 313 CAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT--CRCSQ----PRCIM--HEGNPPIT 364

Query: 375 MFSDCSQA-YLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNR 433
            FS+CS   + E  +ER +  CL        +     CGN  VE GE+CDCGP + C   
Sbjct: 365 KFSNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKD 422

Query: 434 CCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQE 493
            C  + C L +G+ CA G CC++CK  P+G++CR + + CDL E+C+G   +CP+D + E
Sbjct: 423 PCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVE 482

Query: 494 NGTPC-SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVL 552
           +G PC   GYCY  +C    +QC+  +G G   A E+C+      G +           +
Sbjct: 483 DGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYI 542

Query: 553 QCKGGQQPLGRAIC-----IVDVCHALTTE------------------DGTAYEPVPEGT 589
           +C       GR  C     I ++    T                     G     V +GT
Sbjct: 543 KCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGT 602

Query: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLTEVHA 649
            CG + +C    C  + +  S+   A C+  G+CN+K  CHC+  W PP+C         
Sbjct: 603 ECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSV 662

Query: 650 ASGSLP------VFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSNPLF 703
            SG  P       F  + ++LL V+ + L    +YR  +               +S P+ 
Sbjct: 663 DSGPPPKRKKKKKFCYLCILLLIVLFILLC--CLYRLCK---------------KSKPIK 705

Query: 704 HQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARHPASSVALKRPPPAPPVTVSSPPFPV 763
            Q   + P+        R P EL P +   QP   P+ S     P  + P  + S   P 
Sbjct: 706 KQQDVQTPSAKEEEKIQRRPHELPPQS---QPWVMPSQSQPPVTPSQSHPQVMPSQSQP- 761

Query: 764 PVYTRQAPKQVIKPTFAPPVPP 785
           PV   Q+  +V+     PPV P
Sbjct: 762 PVTPSQSQPRVMPSQSQPPVMP 783


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  290 bits (741), Expect = 5e-78
 Identities = 206/719 (28%), Positives = 325/719 (45%), Gaps = 87/719 (12%)

Query: 41  RVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPR 100
           RVR  L      H ++ S+ + A G +F L +  N DLL S Y E +    G  V  + +
Sbjct: 73  RVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTV--EVK 130

Query: 101 GQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG---EGGRHAVYQA 157
           G +HC+YQGH+ G PDS  +LSTC GL G F  G+  +LIEP +      +   H+VY++
Sbjct: 131 GGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKS 190

Query: 158 EHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS---------RETRYVELYVVV 208
              L       +  +     + P +  + +PRP  S             ET+Y+EL +V 
Sbjct: 191 R--LFEFSLDDLPSEFQQVNITP-SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVN 247

Query: 209 DNAEFQMLGSEAAVRHR---VLEVVNHVDKLYQ-KLNFRVVLVGLEIWNSQDRFHVSPDP 264
           D+  F+      +V H       VVN  D +Y+ +L  R+VLV +E W + ++F +S +P
Sbjct: 248 DHLMFKK--HRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENP 305

Query: 265 SVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKN 324
            +TL   + +  R+   +   D V L +G  F  +  G A +  +CS   G    +  K 
Sbjct: 306 LITLREFMKY--RRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT 363

Query: 325 PVGVACTMAHEMGHNLGMDHDENVQG---CRCQERFEAGRCIMAGSIGSSFPRMFSDCSQ 381
            + +A T+A  + HN+G+  D+       C+C++ +    CIM G  G   P+ F+ C+ 
Sbjct: 364 DL-MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSG--CIM-GDTGYYLPKKFTQCNI 419

Query: 382 AYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDC---RNRCCNST 438
                FL      CL N P  S L+  P CGN F+E GE+CDCG P +C      CC   
Sbjct: 420 EEYHDFLNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK- 476

Query: 439 TCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPC 498
            C L + +QC+ G CC++CK +P G +CR   + CD+ E C G   +C  +  + +G  C
Sbjct: 477 -CTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSC 535

Query: 499 SG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKG 556
            G  G C+ G C T  +QC+  WG    A+++ C+    + G +      D    +QC  
Sbjct: 536 DGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNK 595

Query: 557 GQQPLGRAICIV------------DVCHALTTEDGTAYEP---------------VPEGT 589
                G  +C              ++   L  + G                    V +GT
Sbjct: 596 RDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCAKLL 644
            CGP+ +C + RC  +  +  S C +      C  +GVC+++ +C C+  W    C    
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715

Query: 645 TEVHAA------SGS--------LPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRN 689
                A      SG+        + +    +LVL  ++ +T  G   YR+ RS  LS +
Sbjct: 716 PHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHS 774


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  290 bits (741), Expect = 5e-78
 Identities = 206/719 (28%), Positives = 325/719 (45%), Gaps = 87/719 (12%)

Query: 41  RVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPR 100
           RVR  L      H ++ S+ + A G +F L +  N DLL S Y E +    G  V  + +
Sbjct: 73  RVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTV--EVK 130

Query: 101 GQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG---EGGRHAVYQA 157
           G +HC+YQGH+ G PDS  +LSTC GL G F  G+  +LIEP +      +   H+VY++
Sbjct: 131 GGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKS 190

Query: 158 EHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS---------RETRYVELYVVV 208
              L       +  +     + P +  + +PRP  S             ET+Y+EL +V 
Sbjct: 191 R--LFEFSLDDLPSEFQQVNITP-SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVN 247

Query: 209 DNAEFQMLGSEAAVRHR---VLEVVNHVDKLYQ-KLNFRVVLVGLEIWNSQDRFHVSPDP 264
           D+  F+      +V H       VVN  D +Y+ +L  R+VLV +E W + ++F +S +P
Sbjct: 248 DHLMFKK--HRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENP 305

Query: 265 SVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKN 324
            +TL   + +  R+   +   D V L +G  F  +  G A +  +CS   G    +  K 
Sbjct: 306 LITLREFMKY--RRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT 363

Query: 325 PVGVACTMAHEMGHNLGMDHDENVQG---CRCQERFEAGRCIMAGSIGSSFPRMFSDCSQ 381
            + +A T+A  + HN+G+  D+       C+C++ +    CIM G  G   P+ F+ C+ 
Sbjct: 364 DL-MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSG--CIM-GDTGYYLPKKFTQCNI 419

Query: 382 AYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDC---RNRCCNST 438
                FL      CL N P  S L+  P CGN F+E GE+CDCG P +C      CC   
Sbjct: 420 EEYHDFLNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK- 476

Query: 439 TCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPC 498
            C L + +QC+ G CC++CK +P G +CR   + CD+ E C G   +C  +  + +G  C
Sbjct: 477 -CTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSC 535

Query: 499 SG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKG 556
            G  G C+ G C T  +QC+  WG    A+++ C+    + G +      D    +QC  
Sbjct: 536 DGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNK 595

Query: 557 GQQPLGRAICIV------------DVCHALTTEDGTAYEP---------------VPEGT 589
                G  +C              ++   L  + G                    V +GT
Sbjct: 596 RDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCAKLL 644
            CGP+ +C + RC  +  +  S C +      C  +GVC+++ +C C+  W    C    
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715

Query: 645 TEVHAA------SGS--------LPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRN 689
                A      SG+        + +    +LVL  ++ +T  G   YR+ RS  LS +
Sbjct: 716 PHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHS 774


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  290 bits (741), Expect = 5e-78
 Identities = 206/719 (28%), Positives = 325/719 (45%), Gaps = 87/719 (12%)

Query: 41  RVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPR 100
           RVR  L      H ++ S+ + A G +F L +  N DLL S Y E +    G  V  + +
Sbjct: 73  RVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTV--EVK 130

Query: 101 GQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG---EGGRHAVYQA 157
           G +HC+YQGH+ G PDS  +LSTC GL G F  G+  +LIEP +      +   H+VY++
Sbjct: 131 GGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKS 190

Query: 158 EHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS---------RETRYVELYVVV 208
              L       +  +     + P +  + +PRP  S             ET+Y+EL +V 
Sbjct: 191 R--LFEFSLDDLPSEFQQVNITP-SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVN 247

Query: 209 DNAEFQMLGSEAAVRHR---VLEVVNHVDKLYQ-KLNFRVVLVGLEIWNSQDRFHVSPDP 264
           D+  F+      +V H       VVN  D +Y+ +L  R+VLV +E W + ++F +S +P
Sbjct: 248 DHLMFKK--HRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENP 305

Query: 265 SVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKN 324
            +TL   + +  R+   +   D V L +G  F  +  G A +  +CS   G    +  K 
Sbjct: 306 LITLREFMKY--RRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT 363

Query: 325 PVGVACTMAHEMGHNLGMDHDENVQG---CRCQERFEAGRCIMAGSIGSSFPRMFSDCSQ 381
            + +A T+A  + HN+G+  D+       C+C++ +    CIM G  G   P+ F+ C+ 
Sbjct: 364 DL-MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSG--CIM-GDTGYYLPKKFTQCNI 419

Query: 382 AYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDC---RNRCCNST 438
                FL      CL N P  S L+  P CGN F+E GE+CDCG P +C      CC   
Sbjct: 420 EEYHDFLNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK- 476

Query: 439 TCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPC 498
            C L + +QC+ G CC++CK +P G +CR   + CD+ E C G   +C  +  + +G  C
Sbjct: 477 -CTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSC 535

Query: 499 SG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKG 556
            G  G C+ G C T  +QC+  WG    A+++ C+    + G +      D    +QC  
Sbjct: 536 DGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNK 595

Query: 557 GQQPLGRAICIV------------DVCHALTTEDGTAYEP---------------VPEGT 589
                G  +C              ++   L  + G                    V +GT
Sbjct: 596 RDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCAKLL 644
            CGP+ +C + RC  +  +  S C +      C  +GVC+++ +C C+  W    C    
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715

Query: 645 TEVHAA------SGS--------LPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRN 689
                A      SG+        + +    +LVL  ++ +T  G   YR+ RS  LS +
Sbjct: 716 PHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHS 774


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  286 bits (732), Expect = 6e-77
 Identities = 203/712 (28%), Positives = 321/712 (45%), Gaps = 87/712 (12%)

Query: 41  RVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPR 100
           RVR  L      H ++ S+ + A G +F L +  N DLL S Y E +    G  V  + +
Sbjct: 73  RVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTV--EVK 130

Query: 101 GQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG---EGGRHAVYQA 157
           G +HC+YQGH+ G PDS  +LSTC GL G F  G+  +LIEP +      +   H+VY++
Sbjct: 131 GGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKS 190

Query: 158 EHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS---------RETRYVELYVVV 208
              L       +  +     + P +  + +PRP  S             ET+Y+EL +V 
Sbjct: 191 R--LFEFSLDDLPSEFQQVNITP-SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVN 247

Query: 209 DNAEFQMLGSEAAVRHR---VLEVVNHVDKLYQ-KLNFRVVLVGLEIWNSQDRFHVSPDP 264
           D+  F+      +V H       VVN  D +Y+ +L  R+VLV +E W + ++F +S +P
Sbjct: 248 DHLMFKK--HRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENP 305

Query: 265 SVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKN 324
            +TL   + +  R+   +   D V L +G  F  +  G A +  +CS   G    +  K 
Sbjct: 306 LITLREFMKY--RRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT 363

Query: 325 PVGVACTMAHEMGHNLGMDHDENVQG---CRCQERFEAGRCIMAGSIGSSFPRMFSDCSQ 381
            + +A T+A  + HN+G+  D+       C+C++ +    CIM G  G   P+ F+ C+ 
Sbjct: 364 DL-MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSG--CIM-GDTGYYLPKKFTQCNI 419

Query: 382 AYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDC---RNRCCNST 438
                FL      CL N P  S L+  P CGN F+E GE+CDCG P +C      CC   
Sbjct: 420 EEYHDFLNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK- 476

Query: 439 TCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPC 498
            C L + +QC+ G CC++CK +P G +CR   + CD+ E C G   +C  +  + +G  C
Sbjct: 477 -CTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSC 535

Query: 499 SG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKG 556
            G  G C+ G C T  +QC+  WG    A+++ C+    + G +      D    +QC  
Sbjct: 536 DGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNK 595

Query: 557 GQQPLGRAICIV------------DVCHALTTEDGTAYEP---------------VPEGT 589
                G  +C              ++   L  + G                    V +GT
Sbjct: 596 RDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCAKLL 644
            CGP+ +C + RC  +  +  S C +      C  +GVC+++ +C C+  W    C    
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715

Query: 645 TEVHAA------SGS--------LPVFVVVVLVLLAVVLVTLAGIIVYRKAR 682
                A      SG+        + +    +LVL  ++ +T  G   YR+ R
Sbjct: 716 PHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQR 767


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score =  286 bits (732), Expect = 6e-77
 Identities = 203/712 (28%), Positives = 321/712 (45%), Gaps = 87/712 (12%)

Query: 41  RVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPR 100
           RVR  L      H ++ S+ + A G +F L +  N DLL S Y E +    G  V  + +
Sbjct: 73  RVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTV--EVK 130

Query: 101 GQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG---EGGRHAVYQA 157
           G +HC+YQGH+ G PDS  +LSTC GL G F  G+  +LIEP +      +   H+VY++
Sbjct: 131 GGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKS 190

Query: 158 EHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS---------RETRYVELYVVV 208
              L       +  +     + P +  + +PRP  S             ET+Y+EL +V 
Sbjct: 191 R--LFEFSLDDLPSEFQQVNITP-SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVN 247

Query: 209 DNAEFQMLGSEAAVRHR---VLEVVNHVDKLYQ-KLNFRVVLVGLEIWNSQDRFHVSPDP 264
           D+  F+      +V H       VVN  D +Y+ +L  R+VLV +E W + ++F +S +P
Sbjct: 248 DHLMFKK--HRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENP 305

Query: 265 SVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKN 324
            +TL   + +  R+   +   D V L +G  F  +  G A +  +CS   G    +  K 
Sbjct: 306 LITLREFMKY--RRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT 363

Query: 325 PVGVACTMAHEMGHNLGMDHDENVQG---CRCQERFEAGRCIMAGSIGSSFPRMFSDCSQ 381
            + +A T+A  + HN+G+  D+       C+C++ +    CIM G  G   P+ F+ C+ 
Sbjct: 364 DL-MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSG--CIM-GDTGYYLPKKFTQCNI 419

Query: 382 AYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDC---RNRCCNST 438
                FL      CL N P  S L+  P CGN F+E GE+CDCG P +C      CC   
Sbjct: 420 EEYHDFLNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK- 476

Query: 439 TCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPC 498
            C L + +QC+ G CC++CK +P G +CR   + CD+ E C G   +C  +  + +G  C
Sbjct: 477 -CTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSC 535

Query: 499 SG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKG 556
            G  G C+ G C T  +QC+  WG    A+++ C+    + G +      D    +QC  
Sbjct: 536 DGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNK 595

Query: 557 GQQPLGRAICIV------------DVCHALTTEDGTAYEP---------------VPEGT 589
                G  +C              ++   L  + G                    V +GT
Sbjct: 596 RDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655

Query: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCAKLL 644
            CGP+ +C + RC  +  +  S C +      C  +GVC+++ +C C+  W    C    
Sbjct: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715

Query: 645 TEVHAA------SGS--------LPVFVVVVLVLLAVVLVTLAGIIVYRKAR 682
                A      SG+        + +    +LVL  ++ +T  G   YR+ R
Sbjct: 716 PHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQR 767


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score =  278 bits (711), Expect = 2e-74
 Identities = 211/738 (28%), Positives = 338/738 (45%), Gaps = 83/738 (11%)

Query: 6   LWLLGAMMLPAIAPS---RPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLG 62
           L L+  M+L ++       P    + YEV +P +L      + + S        VSY+L 
Sbjct: 15  LLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSP-------VSYLLQ 67

Query: 63  ATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLS 122
             G    LHL   R LL           +G  + + P     C Y G V+   DS A++S
Sbjct: 68  LKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATIS 127

Query: 123 TC-AGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGP- 180
           TC  GLRG F + +  + IEPL +      H VY  +        CG+SDD +   + P 
Sbjct: 128 TCMGGLRGVFNIDAKHYQIEPL-KASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPY 186

Query: 181 RTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAA-VRHRVLEVVNHVDKLYQK 239
              A  R  PG     +  +Y+EL ++ D + ++ + +  + V H  + +   +D  +Q 
Sbjct: 187 ENKARLRDFPGSY---KHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQD 243

Query: 240 LNFRVVLVGLEIWNSQDRFHVS-PDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTG 298
           +  R+ L  LE+W   ++  V  P+ +  L   + ++      R   D   L     +  
Sbjct: 244 VRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYND 303

Query: 299 TTV-GFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERF 357
                F +V ++    +G+V+     N +  A   AHE+GH +GM HDE  Q C+C+ R 
Sbjct: 304 ALAWSFGKVCSL--EYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDE--QYCQCRGRL 359

Query: 358 EAGRCIM-AGSIGSSFPRMFSDCSQAYLESFLERPQS--VCLANAPDLSHLVGGPVCGNL 414
               CIM +G  G      FS+CS     SF +   S   CL N P L +++    CGN 
Sbjct: 360 N---CIMGSGRTG------FSNCSYI---SFFKHISSGATCLNNIPGLGYVLKR--CGNK 405

Query: 415 FVERGEQCDCGPPEDC-RNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMC 473
            VE  E+CDCG  E+C ++RCC S  C+L  GA C+ G CC +C+ +P+G +CR + + C
Sbjct: 406 IVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNEC 464

Query: 474 DLEEFCDGRHPECPEDAFQENGTPCS-GGYCYNGACPTLAQQCQAFWGPGGQAAEESCFS 532
           DL E+CDG    CP D ++++GTPC   G C+   C +   QCQ+ +GP    A   C+ 
Sbjct: 465 DLAEYCDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYD 524

Query: 533 Y-----DILPGCKASRYR--------ADMCGVLQCKGGQQPLGRAICIVDVCHALTTED- 578
                 D    C+ +  R          +CG LQC   +           +   L  E+ 
Sbjct: 525 AVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENL 584

Query: 579 ---GTAYE------------PVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVC 623
              GT Y              + +GT CG  +VC+K  C +  V +      +C+  GVC
Sbjct: 585 MCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVC 644

Query: 624 NHKQECHCHAGWAPPHCAKLLTEVHAAS-------GSLPVFV-VVVLVLLAVVLVTLAGI 675
           N+++ CHC  GWAPP C ++       S       G++P  + VV +++  ++L+ L+ +
Sbjct: 645 NNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVV 704

Query: 676 IVYRKARSRILSRNVAPK 693
            V+ +   +++  ++ PK
Sbjct: 705 FVFFR---QVIGNHLKPK 719


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  270 bits (689), Expect = 5e-72
 Identities = 194/659 (29%), Positives = 290/659 (44%), Gaps = 68/659 (10%)

Query: 34  PWRLPGPRVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGS 93
           P+ +   + R     +  +H  + S+ + A G  F L L  N  LL S Y E +   NG 
Sbjct: 128 PYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGK 186

Query: 94  EVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPL----DEGGEG 149
              +  +G +HC+Y G + G  DS  +LSTC GL G F+  + +++IEPL    DE   G
Sbjct: 187 P--QYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTG 244

Query: 150 GRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAV-----FRPRPGDSLPSR----ETR 200
             H + +       AG       +L    G +   +      + R     PSR    E +
Sbjct: 245 RPHIIQKT-----LAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMK 299

Query: 201 YVELYVVVDNAEFQM-LGSEAAVRHRVLEVVNHVDKLY-QKLNFRVVLVGLEIWNSQDRF 258
           Y+EL +V D+  ++    S A   +    VVN VD +Y ++LN RVVLV +E W  +D+ 
Sbjct: 300 YLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQI 359

Query: 259 HVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVN 318
            ++ +P   L     +  RQR ++H  D V LI+ V F       +    +CS + G V 
Sbjct: 360 DITTNPVQMLHEFSKY--RQRIKQHA-DAVHLISRVTFHYKRSSLSYFGGVCSRTRG-VG 415

Query: 319 QDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSD 378
            +    P+ VA  ++  +  NLG+  + + +  +C      G CIM    G S  R FS 
Sbjct: 416 VNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSK 474

Query: 379 CSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNST 438
           CS      FL+R    CL N P  + L     CGN +VE GE+CDCG   +C   CC   
Sbjct: 475 CSILEYRDFLQRGGGACLFNRP--TKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK- 531

Query: 439 TCQLAEGAQCAHGTCCQ--ECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGT 496
            C L+ GA C+ G CC    C  +P G  CR   + CD+ E+C G   +CP +  +++G 
Sbjct: 532 -CSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGY 590

Query: 497 PC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQC 554
            C  + G CYNG C T   QCQ  WG     +++ C+      G +      D    +QC
Sbjct: 591 ACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQC 650

Query: 555 KGGQQPLGRAIC--------------------------IVDVCHA-LTTEDGTAYEPVPE 587
                  G  +C                          ++D   A +  +D T    V +
Sbjct: 651 SKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVED 710

Query: 588 GTRCGPEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCA 641
           GT CGP  +C   +C  +     S+C        C  HGVC+++  C C   WA   C+
Sbjct: 711 GTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769


>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
           sapiens]
          Length = 787

 Score =  264 bits (675), Expect = 2e-70
 Identities = 212/760 (27%), Positives = 347/760 (45%), Gaps = 75/760 (9%)

Query: 6   LWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATG 65
           LWLL A +   +A SRP       ++V+P      +++        +  E++SY++    
Sbjct: 4   LWLLLAGLCGLLA-SRPGFQNSLLQIVIP-----EKIQTNTNDSSEIEYEQISYIIPIDE 57

Query: 66  HNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCA 125
             +T+HL K R  L   +   Y    GS  T     Q  C+YQG++EGYPDS  +LSTC+
Sbjct: 58  KLYTVHL-KQRYFLADNFM-IYLYNQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCS 115

Query: 126 GLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAV 185
           GLRG  Q  +  + IEPL+   E  +H +Y+ ++  +        D SL     P    +
Sbjct: 116 GLRGILQFENVSYGIEPLESAVE-FQHVLYKLKN--EDNDIAIFIDRSLKE--QPMDDNI 170

Query: 186 FRPRPGD-SLPSRETRYVELYVVVDNAEFQMLGSEA-AVRHRVLEVVNHVDKLYQKLNFR 243
           F     + ++P     Y+E+++VVD   +   GS++  V ++V+E+V   + ++ +    
Sbjct: 171 FISEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVT 230

Query: 244 VVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGF 303
           +VL  LE+W+ +++     +    L+  L W+      R  HD   L+  +D+    +G 
Sbjct: 231 IVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRP-HDIAYLLIYMDYP-RYLGA 288

Query: 304 ARVSAMC--SHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGR 361
                MC   +S+G             A  +   +  +LG+ +D+  + C+C E      
Sbjct: 289 VFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDD-PKKCQCSE----ST 343

Query: 362 CIMAGS-IGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGE 420
           CIM    + S+  + FS CS    ++F+      CL N P +      PVCGN  +E  E
Sbjct: 344 CIMNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNE 403

Query: 421 QCDCGPPEDC-RNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPK-KDMCDLEEF 478
            CDCG    C    CC+  TC L +GA+C  G CC++C++  +G  CRPK    CD+ E 
Sbjct: 404 ICDCGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAEN 463

Query: 479 CDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAEESCF----- 531
           C+G  PEC  D    NG  C      CY+G C  L  +C++ +G G + A  +C+     
Sbjct: 464 CNGSSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQS 523

Query: 532 SYDILPGCKASR--------YRADMCGVLQC-----KGGQQPLG--------RAICI-VD 569
             D    C   R        +R  +CG L C     K   Q  G         ++CI VD
Sbjct: 524 QSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVD 583

Query: 570 VCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDLHVYRSSN--CSAQCHNHGVCNHKQ 627
                T  D  A   V  G++C   +VC    C +  + ++S   CS QC  HGVC+ + 
Sbjct: 584 YKLPRTVPDPLA---VKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRN 640

Query: 628 ECHCHAGWAPPHC------------AKLLTEVHAASGSLP-VFVVVVLVLLAVVLVTLAG 674
           +CHC  G+ PP+C              + + +  ASG     +++  L+ L +++VT A 
Sbjct: 641 KCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTA- 699

Query: 675 IIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKG 714
           I++ RK   +  ++     ++  +S       AS+  ++G
Sbjct: 700 IVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEG 739


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,786,649
Number of Sequences: 37866
Number of extensions: 2481427
Number of successful extensions: 19085
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 257
Number of HSP's successfully gapped in prelim test: 1147
Number of HSP's that attempted gapping in prelim test: 11055
Number of HSP's gapped (non-prelim): 5415
length of query: 856
length of database: 18,247,518
effective HSP length: 111
effective length of query: 745
effective length of database: 14,044,392
effective search space: 10463072040
effective search space used: 10463072040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.