Search of human proteins with 57242800

Search of human proteins with 57242800

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|57242800 acid sphingomyelinase-like phosphodiesterase 3B
isoform 2 [Homo sapiens]
         (373 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|57242800 acid sphingomyelinase-like phosphodiesterase 3B isof...   790   0.0  
gi|57242798 acid sphingomyelinase-like phosphodiesterase 3B isof...   710   0.0  
gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Hom...   294   1e-79
gi|56117840 sphingomyelin phosphodiesterase 1, acid lysosomal is...   147   2e-35
gi|56117842 sphingomyelin phosphodiesterase 1, acid lysosomal is...   105   5e-23
gi|153251270 calcineurin-like phosphoesterase domain containing ...    31   1.6  
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    30   3.5  

>gi|57242800 acid sphingomyelinase-like phosphodiesterase 3B isoform
           2 [Homo sapiens]
          Length = 373

 Score =  790 bits (2041), Expect = 0.0
 Identities = 373/373 (100%), Positives = 373/373 (100%)

Query: 1   MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG 60
           MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG
Sbjct: 1   MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG 60

Query: 61  DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR 120
           DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR
Sbjct: 61  DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR 120

Query: 121 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL 180
           EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL
Sbjct: 121 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL 180

Query: 181 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG 240
           PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG
Sbjct: 181 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG 240

Query: 241 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT 300
           FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT
Sbjct: 241 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT 300

Query: 301 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKVRSPAEARGGGWEGLKCITTFPHSQ 360
           PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKVRSPAEARGGGWEGLKCITTFPHSQ
Sbjct: 301 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLKVRSPAEARGGGWEGLKCITTFPHSQ 360

Query: 361 LIHLPLTTEPQEG 373
           LIHLPLTTEPQEG
Sbjct: 361 LIHLPLTTEPQEG 373


>gi|57242798 acid sphingomyelinase-like phosphodiesterase 3B isoform
           1 [Homo sapiens]
          Length = 455

 Score =  710 bits (1832), Expect = 0.0
 Identities = 335/335 (100%), Positives = 335/335 (100%)

Query: 1   MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG 60
           MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG
Sbjct: 1   MRLLAWLIFLANWGGARAEPGKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWG 60

Query: 61  DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR 120
           DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR
Sbjct: 61  DYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIR 120

Query: 121 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL 180
           EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL
Sbjct: 121 EVFPDTKVYAALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKL 180

Query: 181 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG 240
           PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG
Sbjct: 181 PGPSGAGRIVVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPG 240

Query: 241 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT 300
           FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT
Sbjct: 241 FFEKTQNKAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFIT 300

Query: 301 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLK 335
           PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLK
Sbjct: 301 PGVTPWKTTLPGVVNGANNPAIRVFEYDRATLSLK 335


>gi|24307911 acid sphingomyelinase-like phosphodiesterase 3A [Homo
           sapiens]
          Length = 453

 Score =  294 bits (752), Expect = 1e-79
 Identities = 137/317 (43%), Positives = 198/317 (62%), Gaps = 6/317 (1%)

Query: 14  GGARAEP--GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALI 71
           GG    P  G+FWH+ DLHLDP Y ++ D  +VC S+      + GP+GD LCDSP+ LI
Sbjct: 29  GGRNPPPAIGQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQLI 88

Query: 72  NSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAA 131
            S+   +K    E  F++WTGD  PHVP  +L    V+ ++  +T  I+ +FP+ +V+ A
Sbjct: 89  LSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPA 148

Query: 132 LGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVV 191
           LGNHD+ P++Q P  ++ +YN +A LWKPWL  E+I+  +KG FY +K+       RI+ 
Sbjct: 149 LGNHDYWPQDQLPVVTSKVYNAVANLWKPWLDEEAISTLRKGGFYSQKVTTNPNL-RIIS 207

Query: 192 LNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAWF 251
           LNTNLYY  N +T +  DP  QF+WLE  L ++ +  + VYI+ HVP G+   +QN    
Sbjct: 208 LNTNLYYGPNIMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQNITAM 267

Query: 252 REGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGVPISAMFITPGVTPWKTTLP 311
           RE +NEK + + +K+  VIAGQF+GH H DS  +L D  G P++++F+ P VTP K+ L 
Sbjct: 268 REYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLE 327

Query: 312 GVVNGANNPAIRVFEYD 328
                 NNP IR+F+YD
Sbjct: 328 ---KQTNNPGIRLFQYD 341


>gi|56117840 sphingomyelin phosphodiesterase 1, acid lysosomal
           isoform 1 precursor [Homo sapiens]
          Length = 631

 Score =  147 bits (371), Expect = 2e-35
 Identities = 102/321 (31%), Positives = 147/321 (45%), Gaps = 41/321 (12%)

Query: 26  IADLHLDPDYKVSKDPFQVCP-----SAGSQPV--PDAGPWGDYL-CDSPWALINSSIYA 77
           + DLH D DY    DP    P      +G  P   P AG WG+Y  CD P   + S +  
Sbjct: 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265

Query: 78  MKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDF 137
           +    P  D + WTGD   H    +  +   L  +  +T L+R+      VY A+GNH+ 
Sbjct: 266 LGPAGPF-DMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLGPVPVYPAVGNHES 323

Query: 138 HPKNQFPA-------GSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIV 190
            P N FP         S  +Y  +A+ W+PWL  E++   + G FY      P    R++
Sbjct: 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALS---PYPGLRLI 380

Query: 191 VLNTNLYYTSNA-LTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKA 249
            LN N     N  L  +  DP  Q QWL   L  A   GD V+I+GH+PPG   K+    
Sbjct: 381 SLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKS---- 436

Query: 250 WFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGV--PISAMFITPGVTPWK 307
                ++  Y ++V ++   +A QFFGH H D F + YD+  +  P++  F+ P      
Sbjct: 437 -----WSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSA---- 487

Query: 308 TTLPGVVNGANNPAIRVFEYD 328
           TT  G+     NP  RV++ D
Sbjct: 488 TTYIGL-----NPGYRVYQID 503


>gi|56117842 sphingomyelin phosphodiesterase 1, acid lysosomal
           isoform 2 precursor [Homo sapiens]
          Length = 587

 Score =  105 bits (263), Expect = 5e-23
 Identities = 86/320 (26%), Positives = 130/320 (40%), Gaps = 83/320 (25%)

Query: 26  IADLHLDPDYKVSKDPFQVCP-----SAGSQPV--PDAGPWGDYL-CDSPWALINSSIYA 77
           + DLH D DY    DP    P      +G  P   P AG WG+Y  CD P   + S +  
Sbjct: 206 LTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSG 265

Query: 78  MKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVYAALGNHDF 137
           +    P  D + WTGD   H    +  +   L  +  +T L+R+      VY A+GNH+ 
Sbjct: 266 LGPAGPF-DMVYWTGDIPAHDVWHQTRQDQ-LRALTTVTALVRKFLGPVPVYPAVGNHES 323

Query: 138 HPKNQFPA-------GSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIV 190
            P N FP         S  +Y  +A+ W+PWL  E++                       
Sbjct: 324 TPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEAL----------------------- 360

Query: 191 VLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKAW 250
                                +  ++L  V T   K    V+I+GH+PPG   K+     
Sbjct: 361 ---------------------RTLRYLSSVETQEGKR--KVHIIGHIPPGHCLKS----- 392

Query: 251 FREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSFRMLYDDAGV--PISAMFITPGVTPWKT 308
               ++  Y ++V ++   +A QFFGH H D F + YD+  +  P++  F+ P      T
Sbjct: 393 ----WSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSA----T 444

Query: 309 TLPGVVNGANNPAIRVFEYD 328
           T  G+     NP  RV++ D
Sbjct: 445 TYIGL-----NPGYRVYQID 459


>gi|153251270 calcineurin-like phosphoesterase domain containing 1
           isoform a [Homo sapiens]
          Length = 314

 Score = 31.2 bits (69), Expect = 1.6
 Identities = 43/215 (20%), Positives = 80/215 (37%), Gaps = 31/215 (14%)

Query: 70  LINSSIYAMKEIEPEPDFILWTGDDTPHVPDEKLGEAAVLEIVERLTKLIREVFPDTKVY 129
           L   ++ A+ ++ P+P F +  GD    +P    G+    E  E L +++R V     + 
Sbjct: 67  LTEQAVQAINKLNPKPKFFVLCGDLIHAMP----GKPWRTEQTEDLKRVLRAVDRAIPLV 122

Query: 130 AALGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRI 189
              GNHD         G+      + E  + W  ++  + +  G  +             
Sbjct: 123 LVSGNHDI--------GNTPTAETVEEFCRTW-GDDYFSFWVGGVLF------------- 160

Query: 190 VVLNTNLYYTSNALTADMADPGQQFQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQNKA 249
           +VLN+  Y   +   +       Q QWL++ L+ A +      IV    P F E      
Sbjct: 161 LVLNSQFYENPSKCPSLKQ---AQDQWLDEQLSIARQRHCQHAIVFQHIPLFLESIDEDD 217

Query: 250 WFREGFNEKYLKVVRKH--HRVIAGQFFGHHHTDS 282
            +    ++   K +     H  +   F GH+H ++
Sbjct: 218 DYYFNLSKSTRKKLADKFIHAGVKVVFSGHYHRNA 252


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 30.0 bits (66), Expect = 3.5
 Identities = 27/101 (26%), Positives = 41/101 (40%), Gaps = 16/101 (15%)

Query: 38   SKDPFQVCPSAGSQPVPDAGPWGDYLCDSPWALINSSIYAMKEIEPEPDFILWTGDDTPH 97
            S D     P+       D     D   DSP +++ +S          P+ IL  G++ P 
Sbjct: 4673 SLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPAS---------SPESIL--GEEAPR 4721

Query: 98   VPDEKLG-----EAAVLEIVERLTKLIREVFPDTKVYAALG 133
             P    G     + A+  ++  + +    VFPDTK Y ALG
Sbjct: 4722 FPHLGSGRWEQEDRALSPVIPLIPRASIPVFPDTKPYGALG 4762


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.449 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,554,260
Number of Sequences: 37866
Number of extensions: 800787
Number of successful extensions: 1568
Number of sequences better than 10.0: 7
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1552
Number of HSP's gapped (non-prelim): 9
length of query: 373
length of database: 18,247,518
effective HSP length: 104
effective length of query: 269
effective length of database: 14,309,454
effective search space: 3849243126
effective search space used: 3849243126
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.