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Search of human proteins with 50845382
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
(776 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 1662 0.0
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 940 0.0
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 810 0.0
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 810 0.0
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 810 0.0
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 810 0.0
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 527 e-149
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 506 e-143
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 368 e-101
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 362 e-100
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 353 4e-97
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 337 3e-92
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 331 1e-90
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 329 7e-90
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 325 1e-88
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 310 3e-84
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 309 6e-84
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 302 7e-82
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 298 1e-80
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 286 5e-77
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 286 5e-77
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 286 5e-77
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 286 5e-77
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 286 5e-77
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 286 5e-77
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 281 1e-75
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 281 1e-75
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 281 1e-75
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 281 1e-75
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 281 1e-75
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 1662 bits (4303), Expect = 0.0
Identities = 776/776 (100%), Positives = 776/776 (100%)
Query: 1 MVQLHQDTDPQIPKGQPCTLNSSEGGARPAVPHTLFSSALDRWLHNDSFIMAVGEPLVHI 60
MVQLHQDTDPQIPKGQPCTLNSSEGGARPAVPHTLFSSALDRWLHNDSFIMAVGEPLVHI
Sbjct: 1 MVQLHQDTDPQIPKGQPCTLNSSEGGARPAVPHTLFSSALDRWLHNDSFIMAVGEPLVHI 60
Query: 61 RVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQ 120
RVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQ
Sbjct: 61 RVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQ 120
Query: 121 RYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSG 180
RYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSG
Sbjct: 121 RYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSG 180
Query: 181 GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSY 240
GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSY
Sbjct: 181 GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSY 240
Query: 241 NFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEV 300
NFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEV
Sbjct: 241 NFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEV 300
Query: 301 DVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGV 360
DVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGV
Sbjct: 301 DVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGV 360
Query: 361 AYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMHAYR 420
AYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMHAYR
Sbjct: 361 AYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMHAYR 420
Query: 421 KVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCA 480
KVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCA
Sbjct: 421 KVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCA 480
Query: 481 KDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVY 540
KDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVY
Sbjct: 481 KDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVY 540
Query: 541 VQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTT 600
VQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTT
Sbjct: 541 VQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTT 600
Query: 601 YVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKD 660
YVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKD
Sbjct: 601 YVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKD 660
Query: 661 GTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGG 720
GTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGG
Sbjct: 661 GTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGG 720
Query: 721 SADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEEG 776
SADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEEG
Sbjct: 721 SADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEEG 776
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 940 bits (2429), Expect = 0.0
Identities = 444/721 (61%), Positives = 545/721 (75%), Gaps = 4/721 (0%)
Query: 51 MAVGEPLVHIRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGW 110
MAV LV+IRVTLLLLW G+FLSISG+ QA PSQ+FTSPEVVIPLKVISRGR AKAPGW
Sbjct: 1 MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGW 60
Query: 111 LSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPE 170
LSYSLRFGGQ+++VHMRV KLL + HLPVFTYT++ ALL+DQ FI DDCYYHGYVEG PE
Sbjct: 61 LSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPE 120
Query: 171 SLVALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKI 230
SLV S C GGF G+L+I+ L YEI+PI SATFEHLVYK++S++TQFP MRCGLTE+++
Sbjct: 121 SLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEV 180
Query: 231 AHQ-MELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVN 289
A Q +E + + N L+ S WWTH F+ELVVVV++ +++SQSN + VQ +VF VVN
Sbjct: 181 ARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVN 240
Query: 290 IVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLF 349
IVDS Y L +IL GI+IW N P + ++ VL DFS WK +L+ +LQHD AH+F
Sbjct: 241 IVDSMYQQLGTYIILIGIEIWNQGNVFPMTS-IEQVLNDFSQWKQISLS-QLQHDAAHMF 298
Query: 350 IKDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVC 409
IK++ LG+AYV GIC+ P + GVD F+ + +FA T+ HELGH LGMQHD ++C C
Sbjct: 299 IKNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFC 358
Query: 410 ELQWCIMHAYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGE 469
+ CIM+ +R KF+NCSYA + +T++ G C+ PP G IF LK CGN VVE E
Sbjct: 359 GERGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREE 418
Query: 470 ECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCN 529
+CDCG+++QC +D CCLLNCTL PGAACAFG+CCKDCKF+PSG LCRQ+V ECDLPEWCN
Sbjct: 419 QCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCN 478
Query: 530 GTSHQCPDDVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGN 589
GTSHQCP+D YVQDGI C+ +A+CY+K CNNHD C+EIFG+DA+SASQ+CY+EIN+QGN
Sbjct: 479 GTSHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGN 538
Query: 590 RFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLG 649
RFGHCGI GTTY+KC D+ CGRVQCENV IP L +H T+Q H+N TCWG DYHL
Sbjct: 539 RFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHLR 598
Query: 650 MAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWA 709
M I DIGEVKDGTVCGP KICI KKC S+ LS C P+TCNM+GICNNK HCHC + W+
Sbjct: 599 MNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWS 658
Query: 710 PPYCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTK 769
PPYC+ +GYGGS DSGP L ++ + LS+L L V L++ K TK
Sbjct: 659 PPYCQHRGYGGSIDSGPASAKRGVFLPLI-VIPSLSVLTFLFTVGLLMYLRQCSGPKETK 717
Query: 770 S 770
+
Sbjct: 718 A 718
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 810 bits (2091), Expect = 0.0
Identities = 378/718 (52%), Positives = 488/718 (67%), Gaps = 11/718 (1%)
Query: 60 IRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGG 119
+++ LLL G+FLS SGH Q QY + P+VVIP+++ RG PGWLSY L FGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 120 QRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCS 179
Q++I+H++V KLLF+ HLPVFTYT+Q A+L+DQPF+Q++CYYHGYVEG PESLV+LSTC
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 180 GGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLS 239
GGF G+LQIND YEIKP++ S TFEHLVYK+DS++ QF MR G + +I +ME +
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 240 YNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLE 299
N T KQSS+VGWW H R VE+VVV+DN Y+ + N + + +++ +VNIVDS +
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 300 VDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMK-- 357
V V+L G++IWT N L D+ + + WK+ N+ R+QHD +HLF T G++
Sbjct: 241 VKVLLFGLEIWTNKN-LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFT--TLGLRGL 297
Query: 358 LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMH 417
G+ +G+C + + F + L F+I + H LGHNLGM HD C C CIMH
Sbjct: 298 SGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMH 357
Query: 418 AYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIR 477
TKFSNCSY +W+ T+ C+ + +IF +K CGN VVEEGEECDCG ++
Sbjct: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
Query: 478 QCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPD 537
CAKDPCCL NCTL G+ CAFG+CCKDCKFLPSG +CR++V ECDLPEWCNGTSH+CPD
Sbjct: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
Query: 538 DVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIV 597
D YV+DGI C +CYEK+C++ + QC+ IFG A +AS++CY+E+NT G+R GHCGI
Sbjct: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIK 537
Query: 598 GTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGE 657
TY+KC D+ CGR+QCENV IPN+ +H+TV ND CW TDYHLGM PDIGE
Sbjct: 538 NATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
Query: 658 VKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKG 717
VKDGT CG + ICI + C + L+ C P CN RGICNNK HCHCN+ W PP C KG
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
Query: 718 YGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEE 775
YGGS DSGPPPK + K YL +L L+ L LL CL+ L KK K+ ++
Sbjct: 658 YGGSVDSGPPPKRKKK-----KKFCYLCILLLIVLF-ILLCCLYRLCKKSKPIKKQQD 709
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 810 bits (2091), Expect = 0.0
Identities = 378/718 (52%), Positives = 488/718 (67%), Gaps = 11/718 (1%)
Query: 60 IRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGG 119
+++ LLL G+FLS SGH Q QY + P+VVIP+++ RG PGWLSY L FGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 120 QRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCS 179
Q++I+H++V KLLF+ HLPVFTYT+Q A+L+DQPF+Q++CYYHGYVEG PESLV+LSTC
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 180 GGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLS 239
GGF G+LQIND YEIKP++ S TFEHLVYK+DS++ QF MR G + +I +ME +
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 240 YNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLE 299
N T KQSS+VGWW H R VE+VVV+DN Y+ + N + + +++ +VNIVDS +
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 300 VDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMK-- 357
V V+L G++IWT N L D+ + + WK+ N+ R+QHD +HLF T G++
Sbjct: 241 VKVLLFGLEIWTNKN-LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFT--TLGLRGL 297
Query: 358 LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMH 417
G+ +G+C + + F + L F+I + H LGHNLGM HD C C CIMH
Sbjct: 298 SGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMH 357
Query: 418 AYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIR 477
TKFSNCSY +W+ T+ C+ + +IF +K CGN VVEEGEECDCG ++
Sbjct: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
Query: 478 QCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPD 537
CAKDPCCL NCTL G+ CAFG+CCKDCKFLPSG +CR++V ECDLPEWCNGTSH+CPD
Sbjct: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
Query: 538 DVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIV 597
D YV+DGI C +CYEK+C++ + QC+ IFG A +AS++CY+E+NT G+R GHCGI
Sbjct: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIK 537
Query: 598 GTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGE 657
TY+KC D+ CGR+QCENV IPN+ +H+TV ND CW TDYHLGM PDIGE
Sbjct: 538 NATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
Query: 658 VKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKG 717
VKDGT CG + ICI + C + L+ C P CN RGICNNK HCHCN+ W PP C KG
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
Query: 718 YGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEE 775
YGGS DSGPPPK + K YL +L L+ L LL CL+ L KK K+ ++
Sbjct: 658 YGGSVDSGPPPKRKKK-----KKFCYLCILLLIVLF-ILLCCLYRLCKKSKPIKKQQD 709
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 810 bits (2091), Expect = 0.0
Identities = 378/718 (52%), Positives = 488/718 (67%), Gaps = 11/718 (1%)
Query: 60 IRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGG 119
+++ LLL G+FLS SGH Q QY + P+VVIP+++ RG PGWLSY L FGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 120 QRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCS 179
Q++I+H++V KLLF+ HLPVFTYT+Q A+L+DQPF+Q++CYYHGYVEG PESLV+LSTC
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 180 GGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLS 239
GGF G+LQIND YEIKP++ S TFEHLVYK+DS++ QF MR G + +I +ME +
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 240 YNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLE 299
N T KQSS+VGWW H R VE+VVV+DN Y+ + N + + +++ +VNIVDS +
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 300 VDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMK-- 357
V V+L G++IWT N L D+ + + WK+ N+ R+QHD +HLF T G++
Sbjct: 241 VKVLLFGLEIWTNKN-LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFT--TLGLRGL 297
Query: 358 LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMH 417
G+ +G+C + + F + L F+I + H LGHNLGM HD C C CIMH
Sbjct: 298 SGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMH 357
Query: 418 AYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIR 477
TKFSNCSY +W+ T+ C+ + +IF +K CGN VVEEGEECDCG ++
Sbjct: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
Query: 478 QCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPD 537
CAKDPCCL NCTL G+ CAFG+CCKDCKFLPSG +CR++V ECDLPEWCNGTSH+CPD
Sbjct: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
Query: 538 DVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIV 597
D YV+DGI C +CYEK+C++ + QC+ IFG A +AS++CY+E+NT G+R GHCGI
Sbjct: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIK 537
Query: 598 GTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGE 657
TY+KC D+ CGR+QCENV IPN+ +H+TV ND CW TDYHLGM PDIGE
Sbjct: 538 NATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
Query: 658 VKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKG 717
VKDGT CG + ICI + C + L+ C P CN RGICNNK HCHCN+ W PP C KG
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
Query: 718 YGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEE 775
YGGS DSGPPPK + K YL +L L+ L LL CL+ L KK K+ ++
Sbjct: 658 YGGSVDSGPPPKRKKK-----KKFCYLCILLLIVLF-ILLCCLYRLCKKSKPIKKQQD 709
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 810 bits (2091), Expect = 0.0
Identities = 378/718 (52%), Positives = 488/718 (67%), Gaps = 11/718 (1%)
Query: 60 IRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGG 119
+++ LLL G+FLS SGH Q QY + P+VVIP+++ RG PGWLSY L FGG
Sbjct: 1 MKMLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVIPVRITGTTRGMTPPGWLSYILPFGG 60
Query: 120 QRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCS 179
Q++I+H++V KLLF+ HLPVFTYT+Q A+L+DQPF+Q++CYYHGYVEG PESLV+LSTC
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 180 GGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLS 239
GGF G+LQIND YEIKP++ S TFEHLVYK+DS++ QF MR G + +I +ME +
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 240 YNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLE 299
N T KQSS+VGWW H R VE+VVV+DN Y+ + N + + +++ +VNIVDS +
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 300 VDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMK-- 357
V V+L G++IWT N L D+ + + WK+ N+ R+QHD +HLF T G++
Sbjct: 241 VKVLLFGLEIWTNKN-LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFT--TLGLRGL 297
Query: 358 LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMH 417
G+ +G+C + + F + L F+I + H LGHNLGM HD C C CIMH
Sbjct: 298 SGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMH 357
Query: 418 AYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIR 477
TKFSNCSY +W+ T+ C+ + +IF +K CGN VVEEGEECDCG ++
Sbjct: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
Query: 478 QCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPD 537
CAKDPCCL NCTL G+ CAFG+CCKDCKFLPSG +CR++V ECDLPEWCNGTSH+CPD
Sbjct: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
Query: 538 DVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIV 597
D YV+DGI C +CYEK+C++ + QC+ IFG A +AS++CY+E+NT G+R GHCGI
Sbjct: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIK 537
Query: 598 GTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGE 657
TY+KC D+ CGR+QCENV IPN+ +H+TV ND CW TDYHLGM PDIGE
Sbjct: 538 NATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
Query: 658 VKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKG 717
VKDGT CG + ICI + C + L+ C P CN RGICNNK HCHCN+ W PP C KG
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
Query: 718 YGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRTKSKEDEE 775
YGGS DSGPPPK + K YL +L L+ L LL CL+ L KK K+ ++
Sbjct: 658 YGGSVDSGPPPKRKKK-----KKFCYLCILLLIVLF-ILLCCLYRLCKKSKPIKKQQD 709
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 527 bits (1358), Expect = e-149
Identities = 269/679 (39%), Positives = 389/679 (57%), Gaps = 19/679 (2%)
Query: 57 LVHIRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLR 116
L R+ LLL+ + S+ P F S EV IP K+ RG +SY L+
Sbjct: 8 LSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQ 67
Query: 117 FGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALS 176
G+++++H+ +LL HL VF++TE LL+D P+I DC Y G V+ +S +S
Sbjct: 68 LKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATIS 127
Query: 177 TCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMEL 236
TC GG G+ I+ Y+I+P+ S +FEH+VY + + QF CGL++++I QM
Sbjct: 128 TCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMA- 184
Query: 237 QLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYH 296
Y + F G + H +++EL+++ D RY F +N + V H+ + I+D+++
Sbjct: 185 --PYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQ 242
Query: 297 PLEVDVILTGIDIWTASNPLPTS-GDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQG 355
+ + + L +++WT N + +L VL F I+K LN RL D AHL+++
Sbjct: 243 DVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYN 302
Query: 356 MKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQW-C 414
L ++ K +C + V D ++ A HELGH +GM HD Q+C C + C
Sbjct: 303 DALAWSFGK-VCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNC 361
Query: 415 IMHAYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCG 474
IM + R T FSNCSY ++ S C+ P G + LK CGN +VE+ EECDCG
Sbjct: 362 IMGSGR---TGFSNCSYISFFKHISSGATCLNNIPGLGYV--LKRCGNKIVEDNEECDCG 416
Query: 475 TIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQ 534
+ +C KD CC NC L PGA C+ G+CC DC+F PSG +CRQ+ ECDL E+C+G S
Sbjct: 417 STEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSS 476
Query: 535 CPDDVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHC 594
CP+DVY QDG C C+ K C + +QC+ IFG DA A CY +N G++FG+C
Sbjct: 477 CPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNC 536
Query: 595 GIVG-TTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHL--NDTTCWGTDYHLG-- 649
I G + KC + + +CGR+QC NV IP+L EH+T+ HL + CWGT YHL
Sbjct: 537 EITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMK 596
Query: 650 -MAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEW 708
M IPD+G + DGT CG ++C +K C + L C P+ CN RG+CNN+++CHC + W
Sbjct: 597 PMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGW 656
Query: 709 APPYCKDKGYGGSADSGPP 727
APP+C++ GYGGS DSGPP
Sbjct: 657 APPFCEEVGYGGSIDSGPP 675
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 506 bits (1303), Expect = e-143
Identities = 279/724 (38%), Positives = 401/724 (55%), Gaps = 31/724 (4%)
Query: 60 IRVTLLLLWFGMFLSISGHSQARP----SQYFTSPEVVIPLKVISRGRGAKAP--GWLSY 113
+RV LLL G+ + G ARP + + +S E++ P ++ R A P +SY
Sbjct: 12 LRVRWLLL-LGLVGPVLG--AARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSY 68
Query: 114 SLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLV 173
++ G+ +I+H+ NK L V+TY ++ L+ D P IQ+ C+Y GYVEGV S +
Sbjct: 69 VIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSI 128
Query: 174 ALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQ 233
ALS C G G+L + + Y I+P+ S+ FEH++Y++D D P++CG++ + I +
Sbjct: 129 ALSDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMD--DVYKEPLKCGVSNKDIEKE 185
Query: 234 M-----ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVV 288
E S L++ V R+VEL +VVD RY N T V+ E+ +
Sbjct: 186 TAKDEEEEPPSMTQLLRRRRAV--LPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLA 243
Query: 289 NIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHL 348
N +DS Y L + ++L G++IWT N + G +VL +F W+ L R +HD A L
Sbjct: 244 NYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQL 303
Query: 349 FIKDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDT-QWC 407
+K G G+A+V +C G++VF + FA + HELGHNLGM HD + C
Sbjct: 304 VLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDC 363
Query: 408 VCELQWCIMHAYRKVTTKFSNCSYAQYWDSTIS-SGLCIQPPPYPGNIFRLKYCGNLVVE 466
C + CIM++ + FS+CS + T++ G C+ P P + CGN +V+
Sbjct: 364 SCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVD 423
Query: 467 EGEECDCGTIRQCAKDPCCL-LNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLP 525
GEECDCGT ++C DPCC C L A CA+G CCKDC+FLP GTLCR + ECD+P
Sbjct: 424 AGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVP 483
Query: 526 EWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEI 584
E+CNG+S C DV++Q+G C N A+CY C +D QC+ IFG A++A + C+ E+
Sbjct: 484 EYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEV 543
Query: 585 NTQGNRFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGT 644
N++G+RFG+CG G Y KC T + +CG++QCENV IP + Q T CWG
Sbjct: 544 NSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGV 603
Query: 645 DYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQ-PKTCNMRGICNNKQHCH 703
D+ LG +PD G V +GT CG KIC +C L+ C K C+ G+CN+ ++CH
Sbjct: 604 DFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCH 663
Query: 704 CNHEWAPPYCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVL 763
C + WAPP C+ KGYGGS DSGP N M LL L+ L+ C +
Sbjct: 664 CENGWAPPNCETKGYGGSVDSGPT-------YNEMNTALRDGLLVFFFLIVPLIVCAIFI 716
Query: 764 FKKR 767
F KR
Sbjct: 717 FIKR 720
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 368 bits (944), Expect = e-101
Identities = 231/713 (32%), Positives = 355/713 (49%), Gaps = 53/713 (7%)
Query: 70 GMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQRYIVHMRVN 129
G+ L G + S S ++ IP+K P L+ L+ + I+++ N
Sbjct: 30 GVSLWNQGRADEVVSASVGSGDLWIPVKSFD---SKNHPEVLNIRLQRESKELIINLERN 86
Query: 130 KLLFAAHLPVFTYTEQH--------ALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGG 181
+ L A+ ++TE H +L ++ I CYYHG+V G +S V+LSTCSG
Sbjct: 87 EGLIAS-----SFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSG- 140
Query: 182 FLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYN 241
G++ + Y ++P+ SAT + ++ + + CG +H L+
Sbjct: 141 LRGLIVFENESYVLEPMK-SATNRYKLFP--AKKLKSVRGSCG------SHHNTPNLAAK 191
Query: 242 FTLKQSSFVGWWTHQR-------FVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSF 294
S H+R +VELV+V DN + + V+ + + N VD F
Sbjct: 192 NVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKF 251
Query: 295 YHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDT- 353
Y PL + ++L G+++W + S D L +F W+ L R HD A L
Sbjct: 252 YRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYF 311
Query: 354 QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDT--QWCVCEL 411
QG +G+A + +C + G+ + + + A+TL HELGHN GM HDT + C C++
Sbjct: 312 QGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQM 371
Query: 412 Q----WCIMHAYR--KVTTKFSNCSYAQYWDSTISS-GLCIQPPPYPGNIFRLKYCGNLV 464
CIM+A FS+CS S G+C+ P F + CGN
Sbjct: 372 AVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRF 431
Query: 465 VEEGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDL 524
VEEGEECDCG +C C CTL P A CA G+CC+DC+ P+GT CR CDL
Sbjct: 432 VEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDL 491
Query: 525 PEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQE 583
PE+C G S CP +VY+ DG SC +V+ +CY C H+ QC ++G A+ A C++
Sbjct: 492 PEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFER 551
Query: 584 INTQGNRFGHCGIVG-TTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHL-----N 637
+N+ G+ +G+CG V +++ KC D CG++QC+ P + ++ + ++
Sbjct: 552 VNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGG 611
Query: 638 DTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICN 697
C GT +LG +PD G V GT C KIC+ ++C ++ C+ RG+CN
Sbjct: 612 RILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCN 671
Query: 698 NKQHCHCNHEWAPPYCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLL 750
N+++CHC WAPP+C G+GGS DSGP + + +GL + G L +++LCLL
Sbjct: 672 NRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTI-GIL--VTILCLL 721
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 362 bits (929), Expect = e-100
Identities = 223/689 (32%), Positives = 340/689 (49%), Gaps = 50/689 (7%)
Query: 70 GMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQRYIVHMRVN 129
G+ L G + S S ++ IP+K P L+ L+ + I+++ N
Sbjct: 30 GVSLWNQGRADEVVSASVGSGDLWIPVKSFD---SKNHPEVLNIRLQRESKELIINLERN 86
Query: 130 KLLFAAHLPVFTYTEQH--------ALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGG 181
+ L A+ ++TE H +L ++ I CYYHG+V G +S V+LSTCSG
Sbjct: 87 EGLIAS-----SFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSG- 140
Query: 182 FLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYN 241
G++ + Y ++P+ SAT + ++ + + CG +H L+
Sbjct: 141 LRGLIVFENESYVLEPMK-SATNRYKLFP--AKKLKSVRGSCG------SHHNTPNLAAK 191
Query: 242 FTLKQSSFVGWWTHQR-------FVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSF 294
S H+R +VELV+V DN + + V+ + + N VD F
Sbjct: 192 NVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKF 251
Query: 295 YHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDT- 353
Y PL + ++L G+++W + S D L +F W+ L R HD A L
Sbjct: 252 YRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYF 311
Query: 354 QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDT--QWCVCEL 411
QG +G+A + +C + G+ + + + A+TL HELGHN GM HDT + C C++
Sbjct: 312 QGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQM 371
Query: 412 Q----WCIMHAYR--KVTTKFSNCSYAQYWDSTISS-GLCIQPPPYPGNIFRLKYCGNLV 464
CIM+A FS+CS S G+C+ P F + CGN
Sbjct: 372 AVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRF 431
Query: 465 VEEGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDL 524
VEEGEECDCG +C C CTL P A CA G+CC+DC+ P+GT CR CDL
Sbjct: 432 VEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDL 491
Query: 525 PEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQE 583
PE+C G S CP +VY+ DG SC +V+ +CY C H+ QC ++G A+ A C++
Sbjct: 492 PEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFER 551
Query: 584 INTQGNRFGHCGIVG-TTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHL-----N 637
+N+ G+ +G+CG V +++ KC D CG++QC+ P + ++ + ++
Sbjct: 552 VNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGG 611
Query: 638 DTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICN 697
C GT +LG +PD G V GT C KIC+ ++C ++ C+ RG+CN
Sbjct: 612 RILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCN 671
Query: 698 NKQHCHCNHEWAPPYCKDKGYGGSADSGP 726
N+++CHC WAPP+C G+GGS DSGP
Sbjct: 672 NRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 353 bits (905), Expect = 4e-97
Identities = 221/669 (33%), Positives = 327/669 (48%), Gaps = 51/669 (7%)
Query: 119 GQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPF-----IQDDCYYHGYVEGVPESLV 173
G+ I+ + N+ LFA +YTE H P ++D C+YHG V S V
Sbjct: 73 GRELILDLEKNEQLFAP-----SYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSV 127
Query: 174 ALSTCSGGFLGMLQIN-DLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEK-IA 231
LSTC G G++ ++ +L Y I+P+ S +HL+Y+ S+ + PP CG K
Sbjct: 128 TLSTCRG-IRGLITVSSNLSYVIEPLPDSKG-QHLIYR--SEHLKPPPGNCGFEHSKPTT 183
Query: 232 HQMELQLSYNFT-----LKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFN 286
LQ + +K+ ++VEL +V D + + ++ + +H++
Sbjct: 184 RDWALQFTQQTKKRPRRMKREDL----NSMKYVELYLVADYLEFQKNRRDQDATKHKLIE 239
Query: 287 VVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVA 346
+ N VD FY L + + L G+++WT N S + + L F W+ L + HD A
Sbjct: 240 IANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKY-HDNA 298
Query: 347 HLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQ 405
L G +G+A + +C + GV++ + A T+ HE+GHN GM HD+
Sbjct: 299 QLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSA 358
Query: 406 WCVCELQ----WCIM-----HAYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFR 456
C C CIM H + KV + +Y S G+C+ P ++
Sbjct: 359 DC-CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQS--GGGMCLSNMPDTRMLYG 415
Query: 457 LKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAFGICCKDCKFLPSGTLC 515
+ CGN +E+GEECDCG +C +PCC NCTL PGA CA G CC CK L GTLC
Sbjct: 416 GRRCGNGYLEDGEECDCGEEEEC-NNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLC 474
Query: 516 RQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDAR 574
R+Q +CDLPE+C G S CP + Y DG C A+CY C + QC++++G AR
Sbjct: 475 REQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGAR 534
Query: 575 SASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIP---NLIEHST 630
A C++++N G+ FG+CG + + KC D CG++QC++ P N + T
Sbjct: 535 PAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDT 594
Query: 631 VQQFHLNDTTCWGTDYHLGMA----IPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQ 686
+ C GT + G + D G V GT CG IC +C +
Sbjct: 595 TIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGC 654
Query: 687 PKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSL 746
K CN G+CNN Q+CHC WAPP+C G+GGS DSGP P ++ G V G L + +
Sbjct: 655 GKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESV-GPVVAGVLVAILV 713
Query: 747 LCLLPLVAF 755
L +L L+ +
Sbjct: 714 LAVLMLMYY 722
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 337 bits (864), Expect = 3e-92
Identities = 207/682 (30%), Positives = 336/682 (49%), Gaps = 40/682 (5%)
Query: 67 LWFGMFLSISGHSQARPSQYFTS--PEVVIPLKV---ISRGRGAKAPGWLSYSLRFGGQR 121
+W +FL +SG R F S ++ +P K+ I G ++A SY + G+
Sbjct: 1 MWRVLFL-LSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQA----SYKIVIEGKP 55
Query: 122 YIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGG 181
Y V++ + K + V++Y+ + Q+ C+Y GY+EG P+S+V +STC+G
Sbjct: 56 YTVNL-MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTG- 113
Query: 182 FLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYN 241
G+LQ ++ Y I+P+ S FEH++Y++ L EK +L
Sbjct: 114 LRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADV-----SLYNEKDIESRDLSFKLQ 168
Query: 242 FTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVD 301
Q F +++E+ V+V+ Y S+ T V +VF ++ + ++ + +
Sbjct: 169 SVEPQQDFA------KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNIT 222
Query: 302 VILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGVA 361
+IL+ +++W N + T+G+ + +L F WK L R HDVA L + + +G
Sbjct: 223 IILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLR-PHDVAFLLVYREKSNYVGAT 281
Query: 362 YVKGICQNPFNTGVDVFEDN-RLVVFAITLGHELGHNLGMQHDT-QWCVCELQWCIMHA- 418
+ +C + GV + L A+ L L ++G+ +D C C CIM+
Sbjct: 282 FQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPE 341
Query: 419 --YRKVTTKFSNCSYAQYWDS-TISSGLCIQPPPYPGNIFRLK-YCGNLVVEEGEECDCG 474
+ FSNCS+ + + C+ P F+ + CGN +E GEECDCG
Sbjct: 342 AIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCG 401
Query: 475 TIRQCAK--DPCC-LLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGT 531
T + CA + CC + C G+ CA G CC++C F+ +CR ECDLPE+CNG+
Sbjct: 402 TEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGS 461
Query: 532 SHQCPDDVYVQDGISCNVNAF-CYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNR 590
S CP++ YVQ G C +N + C + C + D QC + FG++ CY +N++ +
Sbjct: 462 SASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDV 521
Query: 591 FGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGM 650
G+CGI + Y +C ++ CG++ C+ VG I +T+ +++ C ++
Sbjct: 522 SGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDH 581
Query: 651 AIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAP 710
A +KDGT CG K+C ++C S +L C CN RG+CNNK+HCHC+ + P
Sbjct: 582 ADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLP 641
Query: 711 PYC---KDKGYGGSADSG--PP 727
P C D GGS DSG PP
Sbjct: 642 PDCSVQSDLWPGGSIDSGNFPP 663
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 331 bits (849), Expect = 1e-90
Identities = 217/727 (29%), Positives = 368/727 (50%), Gaps = 33/727 (4%)
Query: 67 LWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGW--LSYSLRFGGQRYIV 124
LW + + G +RP + ++VIP K+ + + + +SY + + Y V
Sbjct: 4 LWL-LLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTV 62
Query: 125 HMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLG 184
H++ + A + ++ Y Q ++ IQ CYY G +EG P+S+V LSTCS G G
Sbjct: 63 HLK-QRYFLADNFMIYLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCS-GLRG 119
Query: 185 MLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPP-MRCGLTEEKIAHQMELQLSYNFT 243
+LQ ++ Y I+P+ + F+H++YK+ ++D + L E+ + + F
Sbjct: 120 ILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPMDDNI-------FI 172
Query: 244 LKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVI 303
++S ++E+ +VVD Y + S++ V ++V +V + +S + +V ++
Sbjct: 173 SEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIV 232
Query: 304 LTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGVAYV 363
L+ +++W+ N + T G+ D +L+ F WK LN R HD+A+L I LG +
Sbjct: 233 LSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFP 291
Query: 364 KGICQNPFNTGVDVF-EDNRLVVFAITLGHELGHNLGMQH-DTQWCVCELQWCIMH---A 418
+C ++ GV ++ ++ L FA+ + L +LG+ + D + C C CIM+
Sbjct: 292 GTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVV 351
Query: 419 YRKVTTKFSNCSYAQYWDSTISSGL-CIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIR 477
FS+CS + + + G+ C+Q P CGN +E E CDCGT
Sbjct: 352 QSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEA 411
Query: 478 QCAKDPCC-LLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQV-GECDLPEWCNGTSHQC 535
QC CC C L GA C G+CCKDC+ L SG CR + ECD+ E CNG+S +C
Sbjct: 412 QCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPEC 471
Query: 536 PDDVYVQDGISCNVNAF-CYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHC 594
D+ + +G+SC N F CY+ C++ D +C+ +FG+ +R+A +CY+EI +Q +RFG+C
Sbjct: 472 GPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNC 531
Query: 595 G-IVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIP 653
G YV C +++CGR+ C P E+ V + D+ C DY L +P
Sbjct: 532 GRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVP 591
Query: 654 DIGEVKDGTVCGPEKICIRKKC--ASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPP 711
D VK+G+ C ++C+ ++C + ++ S + C+ G+C+++ CHC+ + PP
Sbjct: 592 DPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPP 651
Query: 712 YCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSLL-CLLPLVAFLLFCLHVLFKKRTK- 769
C+ + G S + ME GK LL L+ L ++ VL +K+ K
Sbjct: 652 NCQIRSKGFSIFPEEDMGSIME--RASGKTENTWLLGFLIALPILIVTTAIVLARKQLKK 709
Query: 770 --SKEDE 774
+KE+E
Sbjct: 710 WFAKEEE 716
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 329 bits (843), Expect = 7e-90
Identities = 231/758 (30%), Positives = 354/758 (46%), Gaps = 84/758 (11%)
Query: 52 AVGEPLVHIRVTLLLLWFGMFLSI-SGHSQARPSQYFTSPEVVI---PLKVISRGRGAKA 107
A G PL+ + + LLLLW + GH +P +P V+ P + +S
Sbjct: 8 ARGTPLL-LLLLLLLLWPVPGAGVLQGHIPGQP----VTPHWVLDGQPWRTVSLEEPVSK 62
Query: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFI-----QDDCYYH 162
P +L GQ ++ + N L A Y E H QP + D C+Y
Sbjct: 63 PDMGLVALEAEGQELLLELEKNHRLLAPG-----YIETHYGPDGQPVVLAPNHTDHCHYQ 117
Query: 163 GYVEGVPESLVALSTCSGGFLGMLQIN-DLVYEIKPISVSATFE---HLVYKIDSDDT-- 216
G V G P+S V L TCSG G++ ++ + Y ++P + + H +++++ T
Sbjct: 118 GRVRGFPDSWVVLCTCSG-MSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWK 176
Query: 217 -----QFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYL 271
+ P + G+T Q + T K ++EL +V D+ +L
Sbjct: 177 GTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRK------------YLELYIVADHTLFL 224
Query: 272 FSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSI 331
N + + V N VD L++ V LTG+++WT + + D + L F
Sbjct: 225 TRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQ 284
Query: 332 WKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITL 390
W+ L + HD A L + QG +G+A V+G+C+ + GV + A T+
Sbjct: 285 WRR-GLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATM 343
Query: 391 GHELGHNLGMQHDTQWCVCELQ----WCIM-----HAYRKVTTKFSNCSYAQYWDS-TIS 440
HE+GH+LG+ HD C E C+M H + +V FS CS Q
Sbjct: 344 AHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRV---FSACSRRQLRAFFRKG 400
Query: 441 SGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCCLL-NCTLHPGAACAF 499
G C+ P PG CGN VE GEECDCG ++C +D CC NC+L PGA CA
Sbjct: 401 GGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAH 459
Query: 500 GICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTC 558
G CC C P+G LCRQ +G+CDLPE+C GTS CP DVY+ DG C + +C++ C
Sbjct: 460 GDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGAC 519
Query: 559 NNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGT-TYVKCWTPDIMCGRVQCE 617
+ QC++++G + A ++C+Q +N+ G+ G+CG ++ C D +CG++QC+
Sbjct: 520 PTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ 579
Query: 618 NVG---VIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPD-------IGEVKDGTVCGPE 667
+ P+++ + + TC G +A+P +G V+ GT CGP
Sbjct: 580 GGKPSLLAPHMVPVDSTVHLDGQEVTCRG-----ALALPSAQLDLLGLGLVEPGTQCGPR 634
Query: 668 KICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGGSADSGPP 727
+C ++C C+ G+CN+ +CHC WAPP+C G+GGS DSGP
Sbjct: 635 MVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV 694
Query: 728 PKNNMEGLNVMGKLRYLSLLCLLPLV--AFLLFCLHVL 763
N + L + L LLPL+ A L +C + L
Sbjct: 695 QAENHDTF-----LLAMLLSVLLPLLPGAGLAWCCYRL 727
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 325 bits (832), Expect = 1e-88
Identities = 201/652 (30%), Positives = 311/652 (47%), Gaps = 49/652 (7%)
Query: 91 EVVIPLKVIS-RGRGAKAPGW-------LSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTY 142
EVV P+++ R AK P L Y + G+ +++++ NK L A Y
Sbjct: 29 EVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYY 88
Query: 143 TEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSA 202
+ P I DDCYY G++ S ++STC G G D Y I+P+S
Sbjct: 89 NSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRG-LRGYFSQGDQRYFIEPLSPIH 147
Query: 203 TF--EHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFT----LKQSSFVGWWTHQ 256
EH ++K + D+ + CG+ AH ++ ++ T LK H+
Sbjct: 148 RDGQEHALFKYNPDEKNYDST-CGMDGVLWAHDLQQNIALPATKLVKLKDRKVQ---EHE 203
Query: 257 RFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPL 316
+++E +V+DN + N ++ VF + N V+ Y L V L G++IWT + +
Sbjct: 204 KYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKI 263
Query: 317 PTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIK-DTQGMKLGVAYVKGICQNPFNTGV 375
+ + LE+FS W+ L+ R +HD+A L + G +G+A++ +C +P++ GV
Sbjct: 264 KITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMC-SPYSVGV 322
Query: 376 DVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMHAYRK--VTTKFSNCS--- 430
+ L+ A T+ HE+GHN GM HD C C C+M + T FS+CS
Sbjct: 323 VQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRLS 382
Query: 431 YAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCCLLNCT 490
Y ++++ +S+ C+ P P +I CGN +VE GE+CDCGT +C C C
Sbjct: 383 YDKFFEDKLSN--CLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCK 440
Query: 491 LHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NV 549
+ CA G CC+ C+F +G +CR ECDLPE CNG S CPDD + +G C +
Sbjct: 441 IKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHG 500
Query: 550 NAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDI 609
C TC QC E++G A +SCY N G+++G+C V T + C D
Sbjct: 501 KGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDT 559
Query: 610 MCGRVQC----ENVGVIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCG 665
MCG++ C +N+ ++ T + F DT+ +IG V +GT CG
Sbjct: 560 MCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPEDTS------------QEIGMVANGTKCG 607
Query: 666 PEKICIRKKCASM--VHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKD 715
K+CI +C + + S C K C +C+++ C C W PP C D
Sbjct: 608 DNKVCINAECVDIEKAYKSTNCSSK-CKGHAVCDHELQCQCEEGWIPPDCDD 658
>gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
Length = 739
Score = 310 bits (795), Expect = 3e-84
Identities = 210/723 (29%), Positives = 330/723 (45%), Gaps = 47/723 (6%)
Query: 77 GHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQRYIVHMRVNKLLFAAH 136
G QA V +P K+ S + Y + GQ Y +H+ L
Sbjct: 12 GRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMI-YIITIDGQPYTLHLGKQSFLPQNF 70
Query: 137 LPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIK 196
L V+TY E +L P+ C+Y GY P S V LS CSG G LQ ++ Y I+
Sbjct: 71 L-VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSG-LRGFLQFENISYGIE 128
Query: 197 PISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQ 256
P+ SA FEH++Y++ ++D + +H + Y L
Sbjct: 129 PVESSARFEHIIYQMKNNDPNV-----SILAVNYSHIWQKDQPYKVPLNSQIKNLSKLLP 183
Query: 257 RFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPL 316
+++E+ ++V+ Y + S V ++ V+ +V++ + ++ VIL+ +++W+ N +
Sbjct: 184 QYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQI 243
Query: 317 PTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQGMKLGVAYVKGICQNPFNTGVD 376
TSGD D++L+ F WK L R HD+A+L + +G + +C ++ G+
Sbjct: 244 STSGDADDILQRFLAWKRDYLILR-PHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAGIA 302
Query: 377 VFEDN-RLVVFAITLGHELGHNLGMQHD--TQWCVCELQWCIMH------AYRKVTTKFS 427
++ D L F++ + LG N+G+ +D TQ C C CIM+ + RK+ FS
Sbjct: 303 MYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ-CFCLRATCIMNHEAVSASGRKI---FS 358
Query: 428 NCSYAQY------WDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAK 481
NCS Y +++ L P + CGN ++E EECDCG +C
Sbjct: 359 NCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQ----PVCGNGILESNEECDCGNKNECQF 414
Query: 482 DPCCLLN-CTLHPGAACAFGICCKD-CKFLPSGTLCRQQVG-ECDLPEWCNGTSHQCPDD 538
CC N C L C G CC C+ +GT CR+ + ECD E+CNGTS C D
Sbjct: 415 KKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPD 474
Query: 539 VYVQDGISCNVN-AFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIV 597
Y +G C + A+CY C D QC +IFG+ A+ A +C++E+N+ R +CG
Sbjct: 475 TYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENCGFK 534
Query: 598 GTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTC--WGTDYHLGMAIPDI 655
+ + C D++CG++ C N + + ++ D C T + D
Sbjct: 535 NSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATGSSMRSDGTDN 594
Query: 656 GEVKDGTVCGPEKICIRKKCASMVHLSQACQPKT-CNMRGICNNKQHCHCNHEWAPPYCK 714
V DGT+CGPE C+ K C + + C T C +GICNN +C C PP CK
Sbjct: 595 AYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDCK 654
Query: 715 DK--GYGGSADSGPPPKN----NMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVLFKKRT 768
+ GGS D G K+ +G N ++ C+ + F + V+FK+
Sbjct: 655 FQFGSPGGSIDDGNFQKSGDFYTEKGYNTHWNNWFILSFCI--FLPFFIVFTTVIFKRNE 712
Query: 769 KSK 771
SK
Sbjct: 713 ISK 715
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 309 bits (792), Expect = 6e-84
Identities = 228/758 (30%), Positives = 347/758 (45%), Gaps = 110/758 (14%)
Query: 52 AVGEPLVHIRVTLLLLWFGMFLSI-SGHSQARPSQYFTSPEVVI---PLKVISRGRGAKA 107
A G PL+ + + LLLLW + GH +P +P V+ P + +S
Sbjct: 8 ARGTPLL-LLLLLLLLWPVPGAGVLQGHIPGQP----VTPHWVLDGQPWRTVSLEEPVSK 62
Query: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFI-----QDDCYYH 162
P +L GQ ++ + N L A Y E H QP + D C+Y
Sbjct: 63 PDMGLVALEAEGQELLLELEKNHRLLAPG-----YIETHYGPDGQPVVLAPNHTDHCHYQ 117
Query: 163 GYVEGVPESLVALSTCSGGFLGMLQIN-DLVYEIKPISVSATFE---HLVYKIDSDDT-- 216
G V G P+S V L TCSG G++ ++ + Y ++P + + H +++++ T
Sbjct: 118 GRVRGFPDSWVVLCTCSG-MSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWK 176
Query: 217 -----QFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYL 271
+ P + G+T Q + T K ++EL +V D+ +L
Sbjct: 177 GTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRK------------YLELYIVADHTLFL 224
Query: 272 FSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSI 331
N + + V N VD L++ V LTG+++WT + + D + L F
Sbjct: 225 TRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQ 284
Query: 332 WKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITL 390
W+ L + HD A L + QG +G+A V+G+C+ + GV + A T+
Sbjct: 285 WRR-GLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATM 343
Query: 391 GHELGHNLGMQHDTQWCVCELQ----WCIM-----HAYRKVTTKFSNCSYAQYWDS-TIS 440
HE+GH+LG+ HD C E C+M H + +V FS CS Q
Sbjct: 344 AHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRV---FSACSRRQLRAFFRKG 400
Query: 441 SGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCCLL-NCTLHPGAACAF 499
G C+ P PG CGN VE GEECDCG ++C +D CC NC+L PGA CA
Sbjct: 401 GGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAH 459
Query: 500 GICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTC 558
G CC C P+G LCRQ +G+CDLPE+C GTS CP DVY+ DG C + +C++ C
Sbjct: 460 GDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGAC 519
Query: 559 NNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGT-TYVKCWTPDIMCGRVQCE 617
+ QC++++G + A ++C+Q +N+ G+ G+CG ++ C D +CG++QC+
Sbjct: 520 PTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ 579
Query: 618 NVG---VIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPD-------IGEVKDGTVCGPE 667
+ P+++ + + TC G +A+P +G V+ GT CGP
Sbjct: 580 GGKPSLLAPHMVPVDSTVHLDGQEVTCRG-----ALALPSAQLDLLGLGLVEPGTQCGP- 633
Query: 668 KICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGGSADSGPP 727
R +CN+ +CHC WAPP+C G+GGS DSGP
Sbjct: 634 -------------------------RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV 668
Query: 728 PKNNMEGLNVMGKLRYLSLLCLLPLV--AFLLFCLHVL 763
N + L + L LLPL+ A L +C + L
Sbjct: 669 QAENHDTF-----LLAMLLSVLLPLLPGAGLAWCCYRL 701
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 302 bits (774), Expect = 7e-82
Identities = 185/620 (29%), Positives = 293/620 (47%), Gaps = 31/620 (5%)
Query: 111 LSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPE 170
L Y ++ + ++H+ ++ ++ Y+ + P I D C+Y G + +
Sbjct: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYD 118
Query: 171 SLVALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRC---GLTE 227
S ++STC+G G +IND Y I+P+ S EHLV+K + C T
Sbjct: 119 SAASISTCNG-LRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTR 177
Query: 228 EKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNV 287
+ + E + + S + +++VEL +V D+ Y + +++ ++ +
Sbjct: 178 KTVPGDNESE--------EDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGM 229
Query: 288 VNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHD-VA 346
VN V+ Y L + V L GI+IWT + + +++ L FS W+ L R D V
Sbjct: 230 VNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVV 289
Query: 347 HLFIKDTQGMKLGVAYVKGICQNPFNTGV--DVFEDNRLVVFAITLGHELGHNLGMQHDT 404
L K G++Y G+C ++T + D+ D ++ A + H+LGHNLGMQHD
Sbjct: 290 LLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNII--ANRMAHQLGHNLGMQHDE 347
Query: 405 QWCVCELQWCIMHAYRKVTT-KFSNCSYAQYWDSTIS-SGLCIQPPPYPGNIFRLKYCGN 462
C C C+M + + KFS CS QY C+ P+P N ++CGN
Sbjct: 348 FPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGN 407
Query: 463 LVVEEGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGEC 522
++EGEECDCG ++C C C L PG CA G CC+ C+ +G++CR EC
Sbjct: 408 KKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDEC 467
Query: 523 DLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCY 581
D PE C G S CP D + +G C N +C+ C + QC E+F +A + CY
Sbjct: 468 DFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICY 527
Query: 582 QEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLND--- 638
++NT+GN+FG+C ++ C D+ CG++ C G + +L+ + +HL D
Sbjct: 528 -KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTG-GELSSLLGED--KTYHLKDPQK 583
Query: 639 -TTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASM--VHLSQACQPKTCNMRGI 695
T L DIG V GT CG +C +C +M V++S C P CN +
Sbjct: 584 NATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNC-PSQCNENPV 642
Query: 696 CNNKQHCHCNHEWAPPYCKD 715
+ CHC AP C++
Sbjct: 643 DGHGLQCHCEEGQAPVACEE 662
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 298 bits (763), Expect = 1e-80
Identities = 213/668 (31%), Positives = 315/668 (47%), Gaps = 54/668 (8%)
Query: 67 LWFGMFLSISGHSQARPSQYFTSPEVVIPLKVIS-RGRGAKA------PGWLSYSLRFGG 119
LW + + + +RP EVV+P ++ R R A P +SY L G
Sbjct: 6 LWLLGAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGATG 65
Query: 120 QRYIVHMRVNKLLFAAHLPVFTYTEQHAL-LQDQPFIQDDCYYHGYVEGVPESLVALSTC 178
+ +H+R N+ L + TYT + + +QP QD C+Y G+VEG P+S +LSTC
Sbjct: 66 HNFTLHLRKNRDLLGSGYTE-TYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC 124
Query: 179 SGGFLGMLQINDLVYEIKPISVSATF-EHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQ 237
+G G Q+ ++ I+P+ H VY+ ++ CG++++ + + +
Sbjct: 125 AG-LRGFFQVGSDLHLIEPLDEGGEGGRHAVYQ--AEHLLQTAGTCGVSDDSLGSLLGPR 181
Query: 238 LSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHP 297
+ F + + R+VEL VVVDN + S A V+H V VVN VD Y
Sbjct: 182 TAAVFRPRPGDSLPS-RETRYVELYVVVDNAEFQMLGSEAA-VRHRVLEVVNHVDKLYQK 239
Query: 298 LEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIK-DTQGM 356
L V+L G++IW + + S D LE+ W+ R HD L D G
Sbjct: 240 LNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGT 299
Query: 357 KLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHD--TQWCVCELQW- 413
+G A V +C + + V+ V A T+ HE+GHNLGM HD Q C C+ ++
Sbjct: 300 TVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFE 358
Query: 414 ---CIMHAY--RKVTTKFSNCSYAQYWDSTIS--SGLCIQPPPYPGNIFRLKYCGNLVVE 466
CIM FS+CS A Y +S + +C+ P ++ CGNL VE
Sbjct: 359 AGRCIMAGSIGSSFPRMFSDCSQA-YLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVE 417
Query: 467 EGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPE 526
GE+CDCG C C C L GA CA G CC++CK P+G LCR + CDL E
Sbjct: 418 RGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEE 477
Query: 527 WCNGTSHQCPDDVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINT 586
+C+G +CP+D + ++G C+ +CY C QC+ +G ++A +SC+
Sbjct: 478 FCDGRHPECPEDAFQENGTPCS-GGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDIL 536
Query: 587 QGNRFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGTDY 646
G + + D MCG +QC+ G P V H TT GT Y
Sbjct: 537 PGCKASR-----------YRAD-MCGVLQCKG-GQQPLGRAICIVDVCHAL-TTEDGTAY 582
Query: 647 HLGMAIPDIGEVKDGTVCGPEKICIRKKCASM-VHLSQACQPKTCNMRGICNNKQHCHCN 705
V +GT CGPEK+C + +C + V+ S C + C+ G+CN+KQ CHC+
Sbjct: 583 E---------PVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQ-CHNHGVCNHKQECHCH 632
Query: 706 HEWAPPYC 713
WAPP+C
Sbjct: 633 AGWAPPHC 640
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 286 bits (732), Expect = 5e-77
Identities = 201/632 (31%), Positives = 294/632 (46%), Gaps = 39/632 (6%)
Query: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEG 167
P L L G +I+ + N+ L + Y + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 168 VPESLVALSTCSG--GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGL 225
S V++ TCSG G + + E P + ++ +I D P C L
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGP--PIISRIQ--DLHLPGHTCAL 181
Query: 226 TEEKIAHQM---ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQH 282
+ + H E L ++ V T + VELV+V D+ + + +
Sbjct: 182 SWRESVHTQKPPEHPLGQRHIRRRRDVV---TETKTVELVIVADHSEAQ-KYRDFQHLLN 237
Query: 283 EVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQ 342
V ++D+F+ PL V V L G++ WT + + S + LE+F W+ +L RL
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 343 HDVAHLFIKDT-QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQ 401
HD A L + G +G+A IC F+ GV++ ++ A ++ HELGH+LG+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 402 HDTQW--CVCE----LQWCIMHAYRKVTT--KFSNCSYAQYWDSTISS-GLCI--QPPPY 450
HD C C + CIM A FSNCS + + G C+ + P
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL 417
Query: 451 PGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAF-GICCKDCKF 508
P +CGN+ VE GE+CDCG + C DPCC L C L PGA CA G CC++C+
Sbjct: 418 PP---MAAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQL 473
Query: 509 LPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKE 567
PSG CR G+CDLPE+C G S QCP DV + DG C A C C ++ QC+
Sbjct: 474 RPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQS 533
Query: 568 IFGQDARSASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIPNL- 625
++G A+ A+ C Q NT+GN FG CG +YV C D +CG++QC+ P L
Sbjct: 534 LWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLG 593
Query: 626 -IEHSTVQQFHLNDT--TCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHL- 681
I + +N T C LG + GT CGP +CI +C + L
Sbjct: 594 SIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG 653
Query: 682 SQACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
+Q C+ K C+ G+C++ +HC+C WAPP C
Sbjct: 654 AQECRSK-CHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 286 bits (732), Expect = 5e-77
Identities = 201/632 (31%), Positives = 294/632 (46%), Gaps = 39/632 (6%)
Query: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEG 167
P L L G +I+ + N+ L + Y + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 168 VPESLVALSTCSG--GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGL 225
S V++ TCSG G + + E P + ++ +I D P C L
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGP--PIISRIQ--DLHLPGHTCAL 181
Query: 226 TEEKIAHQM---ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQH 282
+ + H E L ++ V T + VELV+V D+ + + +
Sbjct: 182 SWRESVHTQKPPEHPLGQRHIRRRRDVV---TETKTVELVIVADHSEAQ-KYRDFQHLLN 237
Query: 283 EVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQ 342
V ++D+F+ PL V V L G++ WT + + S + LE+F W+ +L RL
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 343 HDVAHLFIKDT-QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQ 401
HD A L + G +G+A IC F+ GV++ ++ A ++ HELGH+LG+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 402 HDTQW--CVCE----LQWCIMHAYRKVTT--KFSNCSYAQYWDSTISS-GLCI--QPPPY 450
HD C C + CIM A FSNCS + + G C+ + P
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL 417
Query: 451 PGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAF-GICCKDCKF 508
P +CGN+ VE GE+CDCG + C DPCC L C L PGA CA G CC++C+
Sbjct: 418 PP---MAAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQL 473
Query: 509 LPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKE 567
PSG CR G+CDLPE+C G S QCP DV + DG C A C C ++ QC+
Sbjct: 474 RPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQS 533
Query: 568 IFGQDARSASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIPNL- 625
++G A+ A+ C Q NT+GN FG CG +YV C D +CG++QC+ P L
Sbjct: 534 LWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLG 593
Query: 626 -IEHSTVQQFHLNDT--TCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHL- 681
I + +N T C LG + GT CGP +CI +C + L
Sbjct: 594 SIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG 653
Query: 682 SQACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
+Q C+ K C+ G+C++ +HC+C WAPP C
Sbjct: 654 AQECRSK-CHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 286 bits (732), Expect = 5e-77
Identities = 201/632 (31%), Positives = 294/632 (46%), Gaps = 39/632 (6%)
Query: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEG 167
P L L G +I+ + N+ L + Y + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 168 VPESLVALSTCSG--GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGL 225
S V++ TCSG G + + E P + ++ +I D P C L
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGP--PIISRIQ--DLHLPGHTCAL 181
Query: 226 TEEKIAHQM---ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQH 282
+ + H E L ++ V T + VELV+V D+ + + +
Sbjct: 182 SWRESVHTQKPPEHPLGQRHIRRRRDVV---TETKTVELVIVADHSEAQ-KYRDFQHLLN 237
Query: 283 EVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQ 342
V ++D+F+ PL V V L G++ WT + + S + LE+F W+ +L RL
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 343 HDVAHLFIKDT-QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQ 401
HD A L + G +G+A IC F+ GV++ ++ A ++ HELGH+LG+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 402 HDTQW--CVCE----LQWCIMHAYRKVTT--KFSNCSYAQYWDSTISS-GLCI--QPPPY 450
HD C C + CIM A FSNCS + + G C+ + P
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL 417
Query: 451 PGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAF-GICCKDCKF 508
P +CGN+ VE GE+CDCG + C DPCC L C L PGA CA G CC++C+
Sbjct: 418 PP---MAAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQL 473
Query: 509 LPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKE 567
PSG CR G+CDLPE+C G S QCP DV + DG C A C C ++ QC+
Sbjct: 474 RPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQS 533
Query: 568 IFGQDARSASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIPNL- 625
++G A+ A+ C Q NT+GN FG CG +YV C D +CG++QC+ P L
Sbjct: 534 LWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLG 593
Query: 626 -IEHSTVQQFHLNDT--TCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHL- 681
I + +N T C LG + GT CGP +CI +C + L
Sbjct: 594 SIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG 653
Query: 682 SQACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
+Q C+ K C+ G+C++ +HC+C WAPP C
Sbjct: 654 AQECRSK-CHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 286 bits (732), Expect = 5e-77
Identities = 201/632 (31%), Positives = 294/632 (46%), Gaps = 39/632 (6%)
Query: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEG 167
P L L G +I+ + N+ L + Y + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 168 VPESLVALSTCSG--GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGL 225
S V++ TCSG G + + E P + ++ +I D P C L
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGP--PIISRIQ--DLHLPGHTCAL 181
Query: 226 TEEKIAHQM---ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQH 282
+ + H E L ++ V T + VELV+V D+ + + +
Sbjct: 182 SWRESVHTQKPPEHPLGQRHIRRRRDVV---TETKTVELVIVADHSEAQ-KYRDFQHLLN 237
Query: 283 EVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQ 342
V ++D+F+ PL V V L G++ WT + + S + LE+F W+ +L RL
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 343 HDVAHLFIKDT-QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQ 401
HD A L + G +G+A IC F+ GV++ ++ A ++ HELGH+LG+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 402 HDTQW--CVCE----LQWCIMHAYRKVTT--KFSNCSYAQYWDSTISS-GLCI--QPPPY 450
HD C C + CIM A FSNCS + + G C+ + P
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL 417
Query: 451 PGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAF-GICCKDCKF 508
P +CGN+ VE GE+CDCG + C DPCC L C L PGA CA G CC++C+
Sbjct: 418 PP---MAAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQL 473
Query: 509 LPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKE 567
PSG CR G+CDLPE+C G S QCP DV + DG C A C C ++ QC+
Sbjct: 474 RPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQS 533
Query: 568 IFGQDARSASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIPNL- 625
++G A+ A+ C Q NT+GN FG CG +YV C D +CG++QC+ P L
Sbjct: 534 LWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLG 593
Query: 626 -IEHSTVQQFHLNDT--TCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHL- 681
I + +N T C LG + GT CGP +CI +C + L
Sbjct: 594 SIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG 653
Query: 682 SQACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
+Q C+ K C+ G+C++ +HC+C WAPP C
Sbjct: 654 AQECRSK-CHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 286 bits (732), Expect = 5e-77
Identities = 201/632 (31%), Positives = 294/632 (46%), Gaps = 39/632 (6%)
Query: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEG 167
P L L G +I+ + N+ L + Y + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 168 VPESLVALSTCSG--GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGL 225
S V++ TCSG G + + E P + ++ +I D P C L
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGP--PIISRIQ--DLHLPGHTCAL 181
Query: 226 TEEKIAHQM---ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQH 282
+ + H E L ++ V T + VELV+V D+ + + +
Sbjct: 182 SWRESVHTQKPPEHPLGQRHIRRRRDVV---TETKTVELVIVADHSEAQ-KYRDFQHLLN 237
Query: 283 EVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQ 342
V ++D+F+ PL V V L G++ WT + + S + LE+F W+ +L RL
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 343 HDVAHLFIKDT-QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQ 401
HD A L + G +G+A IC F+ GV++ ++ A ++ HELGH+LG+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 402 HDTQW--CVCE----LQWCIMHAYRKVTT--KFSNCSYAQYWDSTISS-GLCI--QPPPY 450
HD C C + CIM A FSNCS + + G C+ + P
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL 417
Query: 451 PGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAF-GICCKDCKF 508
P +CGN+ VE GE+CDCG + C DPCC L C L PGA CA G CC++C+
Sbjct: 418 PP---MAAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQL 473
Query: 509 LPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKE 567
PSG CR G+CDLPE+C G S QCP DV + DG C A C C ++ QC+
Sbjct: 474 RPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQS 533
Query: 568 IFGQDARSASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIPNL- 625
++G A+ A+ C Q NT+GN FG CG +YV C D +CG++QC+ P L
Sbjct: 534 LWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLG 593
Query: 626 -IEHSTVQQFHLNDT--TCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHL- 681
I + +N T C LG + GT CGP +CI +C + L
Sbjct: 594 SIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG 653
Query: 682 SQACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
+Q C+ K C+ G+C++ +HC+C WAPP C
Sbjct: 654 AQECRSK-CHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 286 bits (732), Expect = 5e-77
Identities = 201/632 (31%), Positives = 294/632 (46%), Gaps = 39/632 (6%)
Query: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEG 167
P L L G +I+ + N+ L + Y + + ++C Y G V G
Sbjct: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
Query: 168 VPESLVALSTCSG--GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGL 225
S V++ TCSG G + + E P + ++ +I D P C L
Sbjct: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGP--PIISRIQ--DLHLPGHTCAL 181
Query: 226 TEEKIAHQM---ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQH 282
+ + H E L ++ V T + VELV+V D+ + + +
Sbjct: 182 SWRESVHTQKPPEHPLGQRHIRRRRDVV---TETKTVELVIVADHSEAQ-KYRDFQHLLN 237
Query: 283 EVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQ 342
V ++D+F+ PL V V L G++ WT + + S + LE+F W+ +L RL
Sbjct: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
Query: 343 HDVAHLFIKDT-QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQ 401
HD A L + G +G+A IC F+ GV++ ++ A ++ HELGH+LG+
Sbjct: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
Query: 402 HDTQW--CVCE----LQWCIMHAYRKVTT--KFSNCSYAQYWDSTISS-GLCI--QPPPY 450
HD C C + CIM A FSNCS + + G C+ + P
Sbjct: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL 417
Query: 451 PGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAF-GICCKDCKF 508
P +CGN+ VE GE+CDCG + C DPCC L C L PGA CA G CC++C+
Sbjct: 418 PP---MAAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQL 473
Query: 509 LPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKE 567
PSG CR G+CDLPE+C G S QCP DV + DG C A C C ++ QC+
Sbjct: 474 RPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQS 533
Query: 568 IFGQDARSASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIPNL- 625
++G A+ A+ C Q NT+GN FG CG +YV C D +CG++QC+ P L
Sbjct: 534 LWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLG 593
Query: 626 -IEHSTVQQFHLNDT--TCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHL- 681
I + +N T C LG + GT CGP +CI +C + L
Sbjct: 594 SIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG 653
Query: 682 SQACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
+Q C+ K C+ G+C++ +HC+C WAPP C
Sbjct: 654 AQECRSK-CHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 281 bits (720), Expect = 1e-75
Identities = 183/589 (31%), Positives = 280/589 (47%), Gaps = 42/589 (7%)
Query: 157 DDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFE----HLVYK-- 210
+ CYY G++ G P+S VALSTC G GM + Y I+P T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 211 ---IDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDN 267
DD + +T K + + S + V T +++EL++V D+
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEET--KYIELMIVNDH 249
Query: 268 IRYLFSQSNATTVQHEVFNVVNIVDSFYHP-LEVDVILTGIDIWTASNPLPTSGDLDNVL 326
+ + + + +VVN+ D Y L+ ++L ++ W N S + L
Sbjct: 250 LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITL 309
Query: 327 EDFSIWKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVV 385
+F ++ + + D HLF + + G AY+ GIC GV+ F L+
Sbjct: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLM- 366
Query: 386 FAITLGHELGHNLGMQHDTQW-----CVCELQW--CIM-HAYRKVTTKFSNCSYAQYWDS 437
A+TL L HN+G+ D + C CE W CIM + KF+ C+ +Y D
Sbjct: 367 -AVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDF 425
Query: 438 TISSG-LCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPC-CLLNCTLHPGA 495
S G C+ P + CGN +E GEECDCGT +C + C CTL +
Sbjct: 426 LNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDS 483
Query: 496 ACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCN-VNAFCY 554
C+ G+CCK CKF P GT+CR+ V +CD+ E C+G S QC +++ DG SC+ V C+
Sbjct: 484 QCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICF 543
Query: 555 EKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRV 614
C D QCK I+GQ ++ + CY+++N +G G+CG T+++C D++CG +
Sbjct: 544 GGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYL 603
Query: 615 QCENVGVIPNLIE-----HSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKI 669
C N+G IP L E ST+ C G L + D+G V+DGT CGP+ +
Sbjct: 604 LCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMM 662
Query: 670 CIRKKCASMVHLS-----QACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
C+ +C + + + + C+ G+C+N+ C CN W C
Sbjct: 663 CLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 281 bits (720), Expect = 1e-75
Identities = 183/589 (31%), Positives = 280/589 (47%), Gaps = 42/589 (7%)
Query: 157 DDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFE----HLVYK-- 210
+ CYY G++ G P+S VALSTC G GM + Y I+P T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 211 ---IDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDN 267
DD + +T K + + S + V T +++EL++V D+
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEET--KYIELMIVNDH 249
Query: 268 IRYLFSQSNATTVQHEVFNVVNIVDSFYHP-LEVDVILTGIDIWTASNPLPTSGDLDNVL 326
+ + + + +VVN+ D Y L+ ++L ++ W N S + L
Sbjct: 250 LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITL 309
Query: 327 EDFSIWKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVV 385
+F ++ + + D HLF + + G AY+ GIC GV+ F L+
Sbjct: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLM- 366
Query: 386 FAITLGHELGHNLGMQHDTQW-----CVCELQW--CIM-HAYRKVTTKFSNCSYAQYWDS 437
A+TL L HN+G+ D + C CE W CIM + KF+ C+ +Y D
Sbjct: 367 -AVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDF 425
Query: 438 TISSG-LCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPC-CLLNCTLHPGA 495
S G C+ P + CGN +E GEECDCGT +C + C CTL +
Sbjct: 426 LNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDS 483
Query: 496 ACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCN-VNAFCY 554
C+ G+CCK CKF P GT+CR+ V +CD+ E C+G S QC +++ DG SC+ V C+
Sbjct: 484 QCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICF 543
Query: 555 EKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRV 614
C D QCK I+GQ ++ + CY+++N +G G+CG T+++C D++CG +
Sbjct: 544 GGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYL 603
Query: 615 QCENVGVIPNLIE-----HSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKI 669
C N+G IP L E ST+ C G L + D+G V+DGT CGP+ +
Sbjct: 604 LCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMM 662
Query: 670 CIRKKCASMVHLS-----QACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
C+ +C + + + + C+ G+C+N+ C CN W C
Sbjct: 663 CLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 281 bits (720), Expect = 1e-75
Identities = 183/589 (31%), Positives = 280/589 (47%), Gaps = 42/589 (7%)
Query: 157 DDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFE----HLVYK-- 210
+ CYY G++ G P+S VALSTC G GM + Y I+P T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 211 ---IDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDN 267
DD + +T K + + S + V T +++EL++V D+
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEET--KYIELMIVNDH 249
Query: 268 IRYLFSQSNATTVQHEVFNVVNIVDSFYHP-LEVDVILTGIDIWTASNPLPTSGDLDNVL 326
+ + + + +VVN+ D Y L+ ++L ++ W N S + L
Sbjct: 250 LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITL 309
Query: 327 EDFSIWKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVV 385
+F ++ + + D HLF + + G AY+ GIC GV+ F L+
Sbjct: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLM- 366
Query: 386 FAITLGHELGHNLGMQHDTQW-----CVCELQW--CIM-HAYRKVTTKFSNCSYAQYWDS 437
A+TL L HN+G+ D + C CE W CIM + KF+ C+ +Y D
Sbjct: 367 -AVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDF 425
Query: 438 TISSG-LCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPC-CLLNCTLHPGA 495
S G C+ P + CGN +E GEECDCGT +C + C CTL +
Sbjct: 426 LNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDS 483
Query: 496 ACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCN-VNAFCY 554
C+ G+CCK CKF P GT+CR+ V +CD+ E C+G S QC +++ DG SC+ V C+
Sbjct: 484 QCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICF 543
Query: 555 EKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRV 614
C D QCK I+GQ ++ + CY+++N +G G+CG T+++C D++CG +
Sbjct: 544 GGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYL 603
Query: 615 QCENVGVIPNLIE-----HSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKI 669
C N+G IP L E ST+ C G L + D+G V+DGT CGP+ +
Sbjct: 604 LCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMM 662
Query: 670 CIRKKCASMVHLS-----QACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
C+ +C + + + + C+ G+C+N+ C CN W C
Sbjct: 663 CLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 281 bits (720), Expect = 1e-75
Identities = 183/589 (31%), Positives = 280/589 (47%), Gaps = 42/589 (7%)
Query: 157 DDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFE----HLVYK-- 210
+ CYY G++ G P+S VALSTC G GM + Y I+P T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 211 ---IDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDN 267
DD + +T K + + S + V T +++EL++V D+
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEET--KYIELMIVNDH 249
Query: 268 IRYLFSQSNATTVQHEVFNVVNIVDSFYHP-LEVDVILTGIDIWTASNPLPTSGDLDNVL 326
+ + + + +VVN+ D Y L+ ++L ++ W N S + L
Sbjct: 250 LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITL 309
Query: 327 EDFSIWKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVV 385
+F ++ + + D HLF + + G AY+ GIC GV+ F L+
Sbjct: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLM- 366
Query: 386 FAITLGHELGHNLGMQHDTQW-----CVCELQW--CIM-HAYRKVTTKFSNCSYAQYWDS 437
A+TL L HN+G+ D + C CE W CIM + KF+ C+ +Y D
Sbjct: 367 -AVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDF 425
Query: 438 TISSG-LCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPC-CLLNCTLHPGA 495
S G C+ P + CGN +E GEECDCGT +C + C CTL +
Sbjct: 426 LNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDS 483
Query: 496 ACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCN-VNAFCY 554
C+ G+CCK CKF P GT+CR+ V +CD+ E C+G S QC +++ DG SC+ V C+
Sbjct: 484 QCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICF 543
Query: 555 EKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRV 614
C D QCK I+GQ ++ + CY+++N +G G+CG T+++C D++CG +
Sbjct: 544 GGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYL 603
Query: 615 QCENVGVIPNLIE-----HSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKI 669
C N+G IP L E ST+ C G L + D+G V+DGT CGP+ +
Sbjct: 604 LCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMM 662
Query: 670 CIRKKCASMVHLS-----QACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
C+ +C + + + + C+ G+C+N+ C CN W C
Sbjct: 663 CLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
[Homo sapiens]
Length = 859
Score = 281 bits (720), Expect = 1e-75
Identities = 183/589 (31%), Positives = 280/589 (47%), Gaps = 42/589 (7%)
Query: 157 DDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFE----HLVYK-- 210
+ CYY G++ G P+S VALSTC G GM + Y I+P T E H VYK
Sbjct: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
Query: 211 ---IDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDN 267
DD + +T K + + S + V T +++EL++V D+
Sbjct: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEET--KYIELMIVNDH 249
Query: 268 IRYLFSQSNATTVQHEVFNVVNIVDSFYHP-LEVDVILTGIDIWTASNPLPTSGDLDNVL 326
+ + + + +VVN+ D Y L+ ++L ++ W N S + L
Sbjct: 250 LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITL 309
Query: 327 EDFSIWKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVV 385
+F ++ + + D HLF + + G AY+ GIC GV+ F L+
Sbjct: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLM- 366
Query: 386 FAITLGHELGHNLGMQHDTQW-----CVCELQW--CIM-HAYRKVTTKFSNCSYAQYWDS 437
A+TL L HN+G+ D + C CE W CIM + KF+ C+ +Y D
Sbjct: 367 -AVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDF 425
Query: 438 TISSG-LCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPC-CLLNCTLHPGA 495
S G C+ P + CGN +E GEECDCGT +C + C CTL +
Sbjct: 426 LNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDS 483
Query: 496 ACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCN-VNAFCY 554
C+ G+CCK CKF P GT+CR+ V +CD+ E C+G S QC +++ DG SC+ V C+
Sbjct: 484 QCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICF 543
Query: 555 EKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRV 614
C D QCK I+GQ ++ + CY+++N +G G+CG T+++C D++CG +
Sbjct: 544 GGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYL 603
Query: 615 QCENVGVIPNLIE-----HSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKI 669
C N+G IP L E ST+ C G L + D+G V+DGT CGP+ +
Sbjct: 604 LCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMM 662
Query: 670 CIRKKCASMVHLS-----QACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
C+ +C + + + + C+ G+C+N+ C CN W C
Sbjct: 663 CLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.460
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,949,871
Number of Sequences: 37866
Number of extensions: 1667956
Number of successful extensions: 3985
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 3475
Number of HSP's gapped (non-prelim): 353
length of query: 776
length of database: 18,247,518
effective HSP length: 110
effective length of query: 666
effective length of database: 14,082,258
effective search space: 9378783828
effective search space used: 9378783828
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.