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Search of human proteins with 4758156
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
(1065 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 2175 0.0
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 1182 0.0
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 1165 0.0
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 1164 0.0
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 1157 0.0
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 305 2e-82
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 293 4e-79
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 288 1e-77
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 286 6e-77
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 286 6e-77
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 286 6e-77
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 286 6e-77
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 270 4e-72
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 251 2e-66
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 231 3e-60
gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 223 1e-57
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 155 1e-37
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 155 1e-37
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 142 2e-33
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 142 2e-33
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 136 1e-31
gi|122937319 even-skipped homeobox 2 [Homo sapiens] 59 2e-08
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 59 2e-08
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 59 2e-08
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 57 7e-08
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 55 3e-07
gi|73427806 v-maf musculoaponeurotic fibrosarcoma oncogene homol... 54 8e-07
gi|5453736 v-maf musculoaponeurotic fibrosarcoma oncogene homolo... 54 8e-07
gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 53 2e-06
gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 53 2e-06
>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
Length = 1065
Score = 2175 bits (5637), Expect = 0.0
Identities = 1065/1065 (100%), Positives = 1065/1065 (100%)
Query: 1 MDAAGRGCHLLPLPAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAG 60
MDAAGRGCHLLPLPAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAG
Sbjct: 1 MDAAGRGCHLLPLPAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAG 60
Query: 61 EEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQKEKDEALEE 120
EEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQKEKDEALEE
Sbjct: 61 EEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQKEKDEALEE 120
Query: 121 KLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLW 180
KLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLW
Sbjct: 121 KLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLW 180
Query: 181 LETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGG 240
LETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGG
Sbjct: 181 LETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGG 240
Query: 241 SRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCF 300
SRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCF
Sbjct: 241 SRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCF 300
Query: 301 MLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENK 360
MLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENK
Sbjct: 301 MLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENK 360
Query: 361 GRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEL 420
GRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEL
Sbjct: 361 GRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEL 420
Query: 421 YRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDE 480
YRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDE
Sbjct: 421 YRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDE 480
Query: 481 PVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVT 540
PVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVT
Sbjct: 481 PVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVT 540
Query: 541 LEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQEL 600
LEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQEL
Sbjct: 541 LEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQEL 600
Query: 601 KFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGER 660
KFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGER
Sbjct: 601 KFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGER 660
Query: 661 LHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSV 720
LHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSV
Sbjct: 661 LHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSV 720
Query: 721 PDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDC 780
PDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDC
Sbjct: 721 PDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDC 780
Query: 781 DLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDDRSQEHLH 840
DLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDDRSQEHLH
Sbjct: 781 DLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDDRSQEHLH 840
Query: 841 FVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGM 900
FVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGM
Sbjct: 841 FVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGM 900
Query: 901 IAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHC 960
IAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHC
Sbjct: 901 IAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHC 960
Query: 961 SLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGAS 1020
SLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGAS
Sbjct: 961 SLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGAS 1020
Query: 1021 LRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV 1065
LRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV
Sbjct: 1021 LRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV 1065
>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
Length = 945
Score = 1182 bits (3059), Expect = 0.0
Identities = 590/960 (61%), Positives = 721/960 (75%), Gaps = 81/960 (8%)
Query: 118 LEEKLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGE 177
+EE+ R L RKQVSYRKAI+++GLQHLAP P + ++ R+T+DWSE+A GE
Sbjct: 55 VEERFRQLHLRKQVSYRKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGE 114
Query: 178 HLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFR 237
H+W ETNVSGD CY+GE+ C R KS RRKCA CKIVVHT CIEQLEKINFRCKP+FR
Sbjct: 115 HIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFR 174
Query: 238 EGGSRSPRE-NFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNK 296
E GSR+ RE FVRHHWVHRRRQ+GKC+ CGKGFQQKF+FHSKEIVAISCSWCKQA+H+K
Sbjct: 175 ESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSK 234
Query: 297 VTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGME 356
V+CFML IEEPCSLG HAAV++PPTWI++ ++PQN+LKAS +KKKR SFKRK+SK+G E
Sbjct: 235 VSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKAS-KKKKRASFKRKSSKKGPE 293
Query: 357 QENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKD 416
E + RPF+I+P SPLMKPLLVFVNPKSGGNQG K++Q F+WYLNPRQVFDLSQ GPK+
Sbjct: 294 -EGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKE 352
Query: 417 ALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGG 476
ALE+YRKV NLRILACGGDGTVGWILS LD+L+L P PPV +LPLGTGNDLARTLNWGGG
Sbjct: 353 ALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGG 412
Query: 477 YTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVC-KLPLNVFNNYFSLGF 535
YTDEPVSKIL VE+G VVQLDRW+LH E NP+ PE+ ++G +LPL+VFNNYFSLGF
Sbjct: 413 YTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGF 472
Query: 536 DAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTP 595
DAHVTLEFHESREANPEKFNSRFRNKMFYAG AFSDFL SS+DL+KH++VVCDG DLTP
Sbjct: 473 DAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTP 532
Query: 596 KIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVG 655
KIQ+LK QC+VFLNIPRYCAGTMPWG+PG+HHDFEPQRHDDGY+EVIGFTM SLAALQVG
Sbjct: 533 KIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVG 592
Query: 656 GHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLN 715
GHGERL QCREV+L T K+IP+QVDGEPC+LA + IRI+LRNQA MVQK+KRR++ PL +
Sbjct: 593 GHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHS 652
Query: 716 DPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILV 775
D Q VP++LRI+V+++S+ DYE HYDKE+L+EAS +PLG +V
Sbjct: 653 DQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEAS------------------VPLGTVV 694
Query: 776 VRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLD--- 832
V GD DLE CR +I+RLQ++ + S + Q+LSP+WCFLD
Sbjct: 695 VPGDSDLELCRAHIERLQQEPDGAGAKSP---------------TCQKLSPKWCFLDATT 739
Query: 833 -------DRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWN 885
DR+QEHL++V EI+QDEI+ILDP+++ + PDL + + +
Sbjct: 740 ASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGAS------ARPDLPTPTSPLPTSPCS 793
Query: 886 PALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIES 945
P R S G AP + +++A D KL E
Sbjct: 794 PTPR------SLQGDAAP---------------------PQGEELIEAAKRNDFCKLQEL 826
Query: 946 YKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQ 1005
++ GG L+ + +LLH+A TG+ ++V+Y+LDH P E+LD A E GET LH+AA
Sbjct: 827 HRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILD-AVEENGETCLHQAAAL 885
Query: 1006 RNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV 1065
R +C +V+AGASL KTD +G TP++RA++A D +LAAYLE+RQ+Y++I ED ETAV
Sbjct: 886 GQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 945
>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
Length = 929
Score = 1165 bits (3013), Expect = 0.0
Identities = 589/995 (59%), Positives = 730/995 (73%), Gaps = 83/995 (8%)
Query: 84 EGGADPRGAGSAAAAGAAALDEPAAAGQKEKDEALEEKLRNLTFRKQVSYRKAISRAGLQ 143
+G + R + S +A+ +++ E A + +K K R + +RKAI+++GLQ
Sbjct: 5 DGSPEARSSDSESASASSSGSERDAGPEPDKAPRRLNK-RRFPGLRLFGHRKAITKSGLQ 63
Query: 144 HLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFA- 202
HLAP P + ++ R+T+DWSE+A GEH+W ETNVSGD CY+GE+ C R
Sbjct: 64 HLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLQ 123
Query: 203 KSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRE-NFVRHHWVHRRRQEG 261
KS RRKCA CKIVVHT CIEQLEKINFRCKP+FRE GSR+ RE FVRHHWVHRRRQ+G
Sbjct: 124 KSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDG 183
Query: 262 KCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPP 321
KC+ CGKGFQQKF+FHSKEIVAISCSWCKQA+H+KV+CFML IEEPCSLG HAAV++PP
Sbjct: 184 KCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPP 243
Query: 322 TWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFV 381
TWI++ ++PQN+LKAS +KKKR SFKRK+SK+G E E + RPF+I+P SPLMKPLLVFV
Sbjct: 244 TWILRARRPQNTLKAS-KKKKRASFKRKSSKKGPE-EGRWRPFIIRPTPSPLMKPLLVFV 301
Query: 382 NPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWI 441
NPKSGGNQG K++Q F+WYLNPRQVFDLSQ GPK+ALE+YRKV NLRILACGGDGTVGWI
Sbjct: 302 NPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWI 361
Query: 442 LSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWN 501
LS LD+L+L P PPV +LPLGTGNDLARTLNWGGGYTDEPVSKIL VE+G VVQLDRW+
Sbjct: 362 LSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWD 421
Query: 502 LHVERNPDLPPEELEDGVC-KLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRN 560
LH E NP+ PE+ ++G +LPL+VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRN
Sbjct: 422 LHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRN 481
Query: 561 KMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPW 620
KMFYAG AFSDFL SS+DL+KH++VVCDG DLTPKIQ+LK QC+VFLNIPRYCAGTMPW
Sbjct: 482 KMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPW 541
Query: 621 GNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVD 680
G+PG+HHDFEPQRHDDGY+EVIGFTM SLAALQVGGHGERL QCREV+L T K+IP+QVD
Sbjct: 542 GHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVD 601
Query: 681 GEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGFH 740
GEPC+LA + IRI+LRNQA MVQK+KRR++ PL +D Q VP++LRI+V+++S+ DYE H
Sbjct: 602 GEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALH 661
Query: 741 YDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDCDLETCRMYIDRLQEDLQSVS 800
YDKE+L+EAS +PLG +VV GD DLE CR +I+RLQ++
Sbjct: 662 YDKEQLKEAS------------------VPLGTVVVPGDSDLELCRAHIERLQQEPDGAG 703
Query: 801 SGSQRVHYQDHETSFPRALSAQRLSPRWCFLD----------DRSQEHLHFVMEISQDEI 850
+ S + Q+LSP+WCFLD DR+QEHL++V EI+QDEI
Sbjct: 704 AKSP---------------TCQKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEI 748
Query: 851 FILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDL 910
+ILDP+++ + PDL + + +P R S G AP
Sbjct: 749 YILDPELLGAS------ARPDLPTPTSPLPTSPCSPTPR------SLQGDAAP------- 789
Query: 911 KDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTG 970
+ +++A D KL E ++ GG L+ + +LLH+A TG
Sbjct: 790 --------------PQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTG 835
Query: 971 NGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKT 1030
+ ++V+Y+LDH P E+LD A E GET LH+AA R +C +V+AGASL KTD +G T
Sbjct: 836 SKDVVRYLLDHAPPEILD-AVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDT 894
Query: 1031 PQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV 1065
P++RA++A D +LAAYLE+RQ+Y++I ED ETAV
Sbjct: 895 PRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 929
>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
Length = 1117
Score = 1164 bits (3010), Expect = 0.0
Identities = 586/974 (60%), Positives = 720/974 (73%), Gaps = 95/974 (9%)
Query: 118 LEEKLRNLTFRKQVSYR--------------KAISRAGLQHLAPAHPLSLPVANGPAKEP 163
L ++R L+ R+QV+ R KAI+++GLQHLAP P + ++
Sbjct: 213 LPTRVRPLSRRRQVALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQI 272
Query: 164 RATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIE 223
R+T+DWSE+A GEH+W ETNVSGD CY+GE+ C R KS RRKCA CKIVVHT CIE
Sbjct: 273 RSTVDWSESATYGEHIWFETNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIE 332
Query: 224 QLEKINFRCKPTFREGGSRSPRE-NFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIV 282
QLEKINFRCKP+FRE GSR+ RE FVRHHWVHRRRQ+GKC+ CGKGFQQKF+FHSKEIV
Sbjct: 333 QLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIV 392
Query: 283 AISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKK 342
AISCSWCKQA+H+KV+CFML IEEPCSLG HAAV++PPTWI++ ++PQN+LKAS +KKK
Sbjct: 393 AISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKAS-KKKK 451
Query: 343 RTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLN 402
R SFKRK+SK+G E E + RPF+I+P SPLMKPLLVFVNPKSGGNQG K++Q F+WYLN
Sbjct: 452 RASFKRKSSKKGPE-EGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLN 510
Query: 403 PRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLG 462
PRQVFDLSQ GPK+ALE+YRKV NLRILACGGDGTVGWILS LD+L+L P PPV +LPLG
Sbjct: 511 PRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLG 570
Query: 463 TGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVC-K 521
TGNDLARTLNWGGGYTDEPVSKIL VE+G VVQLDRW+LH E NP+ PE+ ++G +
Sbjct: 571 TGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLHAEPNPEAGPEDRDEGATDR 630
Query: 522 LPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLS 581
LPL+VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAG AFSDFL SS+DL+
Sbjct: 631 LPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLA 690
Query: 582 KHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEV 641
KH++VVCDG DLTPKIQ+LK QC+VFLNIPRYCAGTMPWG+PG+HHDFEPQRHDDGY+EV
Sbjct: 691 KHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEV 750
Query: 642 IGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANM 701
IGFTM SLAALQVGGHGERL QCREV+L T K+IP+QVDGEPC+LA + IRI+LRNQA M
Sbjct: 751 IGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATM 810
Query: 702 VQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGE 761
VQK+KRR++ PL +D Q VP++LRI+V+++S+ DYE HYDKE+L+EAS
Sbjct: 811 VQKAKRRSAAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEAS----------- 859
Query: 762 LVQSFGAIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSA 821
+PLG +VV GD DLE CR +I+RLQ++ + S +
Sbjct: 860 -------VPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSP---------------TC 897
Query: 822 QRLSPRWCFLD----------DRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPD 871
Q+LSP+WCFLD DR+QEHL++V EI+QDEI+ILDP+++ + PD
Sbjct: 898 QKLSPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGAS------ARPD 951
Query: 872 LVVEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSEDHAIL 931
L + + +P R S G AP + ++
Sbjct: 952 LPTPTSPLPTSPCSPTPR------SLQGDAAP---------------------PQGEELI 984
Query: 932 QAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMAD 991
+A D KL E ++ GG L+ + +LLH+A TG+ ++V+Y+LDH P E+LD A
Sbjct: 985 EAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILD-AV 1043
Query: 992 SETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQ 1051
E GET LH+AA R +C +V+AGASL KTD +G TP++RA++A D +LAAYLE+RQ
Sbjct: 1044 EENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQ 1103
Query: 1052 NYKVIGHEDLETAV 1065
+Y++I ED ETAV
Sbjct: 1104 HYQMIQREDQETAV 1117
>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
Length = 895
Score = 1157 bits (2993), Expect = 0.0
Identities = 579/945 (61%), Positives = 709/945 (75%), Gaps = 82/945 (8%)
Query: 134 RKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLG 193
+KAI+++GLQHLAP P + ++ R+T+DWSE+A GEH+W ETNVSGD CY+G
Sbjct: 20 QKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCYVG 79
Query: 194 EENCQVRFA-KSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRE-NFVRH 251
E+ C R KS RRKCA CKIVVHT CIEQLEKINFRCKP+FRE GSR+ RE FVRH
Sbjct: 80 EQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRH 139
Query: 252 HWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSL 311
HWVHRRRQ+GKC+ CGKGFQQKF+FHSKEIVAISCSWCKQA+H+KV+CFML IEEPCSL
Sbjct: 140 HWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSL 199
Query: 312 GAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISS 371
G HAAV++PPTWI++ ++PQN+LKAS +KKKR SFKRK+SK+G E E + RPF+I+P S
Sbjct: 200 GVHAAVVIPPTWILRARRPQNTLKAS-KKKKRASFKRKSSKKGPE-EGRWRPFIIRPTPS 257
Query: 372 PLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILA 431
PLMKPLLVFVNPKSGGNQG K++Q F+WYLNPRQVFDLSQ GPK+ALE+YRKV NLRILA
Sbjct: 258 PLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILA 317
Query: 432 CGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVED 491
CGGDGTVGWILS LD+L+L P PPV +LPLGTGNDLARTLNWGGGYTDEPVSKIL VE+
Sbjct: 318 CGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEE 377
Query: 492 GTVVQLDRWNLHVERNPDLPPEELEDGVC-KLPLNVFNNYFSLGFDAHVTLEFHESREAN 550
G VVQLDRW+LH E NP+ PE+ ++G +LPL+VFNNYFSLGFDAHVTLEFHESREAN
Sbjct: 378 GNVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREAN 437
Query: 551 PEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNI 610
PEKFNSRFRNKMFYAG AFSDFL SS+DL+KH++VVCDG DLTPKIQ+LK QC+VFLNI
Sbjct: 438 PEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNI 497
Query: 611 PRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLL 670
PRYCAGTMPWG+PG+HHDFEPQRHDDGY+EVIGFTM SLAALQVGGHGERL QCREV+L
Sbjct: 498 PRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVVLT 557
Query: 671 TYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNK 730
T K+IP+QVDGEPC+LA + IRI+LRNQA MVQK+KRR++ PL +D Q VP++LRI+V++
Sbjct: 558 TSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR 617
Query: 731 ISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDCDLETCRMYID 790
+S+ DYE HYDKE+L+EAS +PLG +VV GD DLE CR +I+
Sbjct: 618 VSMHDYEALHYDKEQLKEAS------------------VPLGTVVVPGDSDLELCRAHIE 659
Query: 791 RLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLD----------DRSQEHLH 840
RLQ++ + S + Q+LSP+WCFLD DR+QEHL+
Sbjct: 660 RLQQEPDGAGAKSP---------------TCQKLSPKWCFLDATTASRFYRIDRAQEHLN 704
Query: 841 FVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGM 900
+V EI+QDEI+ILDP+++ + PDL + + +P R S G
Sbjct: 705 YVTEIAQDEIYILDPELLGAS------ARPDLPTPTSPLPTSPCSPTPR------SLQGD 752
Query: 901 IAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHC 960
AP + +++A D KL E ++ GG L+ +
Sbjct: 753 AAP---------------------PQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSR 791
Query: 961 SLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGAS 1020
+LLH+A TG+ ++V+Y+LDH P E+LD A E GET LH+AA R +C +V+AGAS
Sbjct: 792 TLLHHAVSTGSKDVVRYLLDHAPPEILD-AVEENGETCLHQAAALGQRTICHYIVEAGAS 850
Query: 1021 LRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV 1065
L KTD +G TP++RA++A D +LAAYLE+RQ+Y++I ED ETAV
Sbjct: 851 LMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV 895
>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
Length = 804
Score = 305 bits (780), Expect = 2e-82
Identities = 202/604 (33%), Positives = 287/604 (47%), Gaps = 80/604 (13%)
Query: 155 VANGPAKEPRATLDWSENAV--NGEHLWLETNVSG----DLCYLGEENCQVRFAKSALRR 208
+ G P L EN V +G+H+W + + +LC N + K L
Sbjct: 220 IQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCL----NMLIGVGKQGLC- 274
Query: 209 KCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGK 268
C+ CK VH C+ R P+ + +S R V HH+ KC +C K
Sbjct: 275 -CSFCKYTVHERCVA-------RAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHK 326
Query: 269 GFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVK 328
+ + + + C WC+ HNK H++ C G I+PPT I V
Sbjct: 327 TVKCY-----QGLTGLHCVWCQITLHNKCAS----HLKPECDCGPLKDHILPPTTICPVV 377
Query: 329 KPQNSLKASNRKKKRTSFKRKASKRGMEQENK----------------GRPFVIKPISSP 372
+ ++R S +K K G +Q NK G+ + P+ P
Sbjct: 378 LQTLPTSGVSVPEERQSTVKK-EKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPV--P 434
Query: 373 LMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILAC 432
PLLVFVNPKSGG QG ++ + F + LNPRQV+ LS GP L +R VP+ R+LAC
Sbjct: 435 GTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLAC 494
Query: 433 GGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDG 492
GGDGTVGW+L +++ + PPV +LPLGTGNDLAR L WGGGY E + KIL +E+
Sbjct: 495 GGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENS 554
Query: 493 TVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPE 552
T + LDRW V +P ++ E G +P ++ NNYFS+G DA + FH RE +PE
Sbjct: 555 TEIMLDRWKFEV-----IPNDKDEKG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPE 608
Query: 553 KFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPR 612
KFNSR +NK +Y S+ + + L + V++ CDG + + + + I LNIP
Sbjct: 609 KFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQI--DLINISLEGIAILNIPS 666
Query: 613 YCAGTMPWGNPGDHHD----------------------FEPQRHDDGYIEVIGFTMA-SL 649
G+ WG F Q D +EV+G A +
Sbjct: 667 MHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEM 726
Query: 650 AALQVG--GHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKR 707
+ G G RL QC V++ T KS+PMQ+DGEP P I+I+ +NQA M+
Sbjct: 727 GQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPP 786
Query: 708 RTSM 711
+T +
Sbjct: 787 KTGL 790
>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
Length = 773
Score = 293 bits (751), Expect = 4e-79
Identities = 195/584 (33%), Positives = 275/584 (47%), Gaps = 80/584 (13%)
Query: 155 VANGPAKEPRATLDWSENAV--NGEHLWLETNVSG----DLCYLGEENCQVRFAKSALRR 208
+ G P L EN V +G+H+W + + +LC N + K L
Sbjct: 220 IQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCL----NMLIGVGKQGLC- 274
Query: 209 KCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGK 268
C+ CK VH C+ R P+ + +S R V HH+ KC +C K
Sbjct: 275 -CSFCKYTVHERCVA-------RAPPSCIKTYVKSKRNTDVMHHYWVEGNCPTKCDKCHK 326
Query: 269 GFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVK 328
+ + + + C WC+ HNK H++ C G I+PPT I V
Sbjct: 327 TVKCY-----QGLTGLHCVWCQITLHNKCAS----HLKPECDCGPLKDHILPPTTICPVV 377
Query: 329 KPQNSLKASNRKKKRTSFKRKASKRGMEQENK----------------GRPFVIKPISSP 372
+ ++R S +K K G +Q NK G+ + P+ P
Sbjct: 378 LQTLPTSGVSVPEERQSTVKK-EKSGSQQPNKVIDKNKMQRANSVTVDGQGLQVTPV--P 434
Query: 373 LMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILAC 432
PLLVFVNPKSGG QG ++ + F + LNPRQV+ LS GP L +R VP+ R+LAC
Sbjct: 435 GTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLNFFRDVPDFRVLAC 494
Query: 433 GGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDG 492
GGDGTVGW+L +++ + PPV +LPLGTGNDLAR L WGGGY E + KIL +E+
Sbjct: 495 GGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIENS 554
Query: 493 TVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPE 552
T + LDRW V +P ++ E G +P ++ NNYFS+G DA + FH RE +PE
Sbjct: 555 TEIMLDRWKFEV-----IPNDKDEKG-DPVPYSIINNYFSIGVDASIAHRFHIMREKHPE 608
Query: 553 KFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPR 612
KFNSR +NK +Y S+ + + L + V++ CDG + + + + I LNIP
Sbjct: 609 KFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQI--DLINISLEGIAILNIPS 666
Query: 613 YCAGTMPWGNPGDHHD----------------------FEPQRHDDGYIEVIGFTMA-SL 649
G+ WG F Q D +EV+G A +
Sbjct: 667 MHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGLEGAMEM 726
Query: 650 AALQVG--GHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMI 691
+ G G RL QC V++ T KS+PMQ+DGEP P +
Sbjct: 727 GQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTV 770
>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
Length = 791
Score = 288 bits (738), Expect = 1e-77
Identities = 183/520 (35%), Positives = 254/520 (48%), Gaps = 61/520 (11%)
Query: 210 CAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKG 269
C CK VH C+ + C T+ S++ R V H KC +C K
Sbjct: 302 CTYCKYTVHERCVSRNIP---GCVKTY----SKAKRSGEVMQHAWVEGNSSVKCDRCHKS 354
Query: 270 FQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKK 329
+ S + A C WC+ FH K L C G I+ PT I + +
Sbjct: 355 IKCYQS-----VTARHCVWCRMTFHRKCELSTL------CDGGELRDHILLPTSICPITR 403
Query: 330 PQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQ 389
+ K+ + + K I +P PLLV VNPKSGG Q
Sbjct: 404 DRPGEKSDGCVSAKGELVMQ----------------YKIIPTPGTHPLLVLVNPKSGGRQ 447
Query: 390 GTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQ 449
G ++L+ F + LNP+QVF+L GP L +R P+ R+LACGGDGTVGWIL +D+
Sbjct: 448 GERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDKAN 507
Query: 450 LSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPD 509
+ PPV VLPLGTGNDLAR L WGGGY ++KIL +E +V LDRW+L V
Sbjct: 508 FAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEV----- 562
Query: 510 LPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAF 569
+P EE+E+G ++P ++ NNYFS+G DA + FH RE +PEKFNSR +NK++Y
Sbjct: 563 IPREEVENG-DQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGT 621
Query: 570 SDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHH-- 627
S+ + + L H+++ CDG + + + + I LNIP GT WG +
Sbjct: 622 SETFAATCKKLHDHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAV 679
Query: 628 --------------DFEPQRHDDGYIEVIGFTMA-SLAALQVG--GHGERLHQCREVMLL 670
F Q D +EV+G A + + G G RL QC V +
Sbjct: 680 IRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIR 739
Query: 671 TYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTS 710
T K +PMQVDGEP I+I+ +NQA M+ +++S
Sbjct: 740 TNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 779
>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 286 bits (733), Expect = 6e-77
Identities = 193/568 (33%), Positives = 280/568 (49%), Gaps = 74/568 (13%)
Query: 175 NGEHLWLETNVSGDL-CYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCK 233
+G+H+W + C L E + + K L C +CK VH C +
Sbjct: 203 DGQHMWRPKRFPRPVYCNLCESS--IGLGKQGL--SCNLCKYTVHDQCA-------MKAL 251
Query: 234 PTFREGGSRSPRENFVRHH-WVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQA 292
P ++S ++ V+ H WV + G+C +C K + +HS + + C WC
Sbjct: 252 PCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWCHLE 306
Query: 293 FHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASK 352
H+ L + C G I+PP+ I S+ AS +K + K S+
Sbjct: 307 IHDDC----LQAVGHECDCGLLRDHILPPSSIYP------SVLASGPDRKNS----KTSQ 352
Query: 353 RGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQE 412
+ M+ N ++ P PLLVFVNPKSGG QG +VL F + LNPRQVF+L ++
Sbjct: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
Query: 413 GPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLN 472
GP+ L L++ VP+ RIL CGGDGTVGWIL +D+ L PPV VLPLGTGNDLAR L
Sbjct: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
Query: 473 WGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFS 532
WGGGY + ++KIL +E VV +DRW++ V P++ E+ +P + NNYFS
Sbjct: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEV------IPQQTEEKSDPVPFQIINNYFS 526
Query: 533 LGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTD 592
+G DA + FH RE PEKFNSR +NK++Y A S+ + + + L + + V G
Sbjct: 527 IGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKP 586
Query: 593 LTPKIQELKFQCIVFLNIPRYCAGTMPWGNP----GDHHDFEPQRH-------------- 634
L + L + I LNIP G+ WG+ GD +
Sbjct: 587 L--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKT 644
Query: 635 -----DDGYIEVIGFTMASLAALQVG-------GHGERLHQCREVMLLTYKSIPMQVDGE 682
D +EV+G A+++G G RL +C E+ T K++PMQ+DGE
Sbjct: 645 CVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGE 700
Query: 683 PCRLAPAMIRISLRNQANMVQKSKRRTS 710
P P I+I+ +NQ M+ R++
Sbjct: 701 PWMQTPCTIKITHKNQMPMLMGPPPRST 728
>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 286 bits (733), Expect = 6e-77
Identities = 193/568 (33%), Positives = 280/568 (49%), Gaps = 74/568 (13%)
Query: 175 NGEHLWLETNVSGDL-CYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCK 233
+G+H+W + C L E + + K L C +CK VH C +
Sbjct: 203 DGQHMWRPKRFPRPVYCNLCESS--IGLGKQGL--SCNLCKYTVHDQCA-------MKAL 251
Query: 234 PTFREGGSRSPRENFVRHH-WVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQA 292
P ++S ++ V+ H WV + G+C +C K + +HS + + C WC
Sbjct: 252 PCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWCHLE 306
Query: 293 FHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASK 352
H+ L + C G I+PP+ I S+ AS +K + K S+
Sbjct: 307 IHDDC----LQAVGHECDCGLLRDHILPPSSIYP------SVLASGPDRKNS----KTSQ 352
Query: 353 RGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQE 412
+ M+ N ++ P PLLVFVNPKSGG QG +VL F + LNPRQVF+L ++
Sbjct: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
Query: 413 GPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLN 472
GP+ L L++ VP+ RIL CGGDGTVGWIL +D+ L PPV VLPLGTGNDLAR L
Sbjct: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
Query: 473 WGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFS 532
WGGGY + ++KIL +E VV +DRW++ V P++ E+ +P + NNYFS
Sbjct: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEV------IPQQTEEKSDPVPFQIINNYFS 526
Query: 533 LGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTD 592
+G DA + FH RE PEKFNSR +NK++Y A S+ + + + L + + V G
Sbjct: 527 IGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKP 586
Query: 593 LTPKIQELKFQCIVFLNIPRYCAGTMPWGNP----GDHHDFEPQRH-------------- 634
L + L + I LNIP G+ WG+ GD +
Sbjct: 587 L--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKT 644
Query: 635 -----DDGYIEVIGFTMASLAALQVG-------GHGERLHQCREVMLLTYKSIPMQVDGE 682
D +EV+G A+++G G RL +C E+ T K++PMQ+DGE
Sbjct: 645 CVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGE 700
Query: 683 PCRLAPAMIRISLRNQANMVQKSKRRTS 710
P P I+I+ +NQ M+ R++
Sbjct: 701 PWMQTPCTIKITHKNQMPMLMGPPPRST 728
>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 286 bits (733), Expect = 6e-77
Identities = 193/568 (33%), Positives = 280/568 (49%), Gaps = 74/568 (13%)
Query: 175 NGEHLWLETNVSGDL-CYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCK 233
+G+H+W + C L E + + K L C +CK VH C +
Sbjct: 203 DGQHMWRPKRFPRPVYCNLCESS--IGLGKQGL--SCNLCKYTVHDQCA-------MKAL 251
Query: 234 PTFREGGSRSPRENFVRHH-WVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQA 292
P ++S ++ V+ H WV + G+C +C K + +HS + + C WC
Sbjct: 252 PCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWCHLE 306
Query: 293 FHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASK 352
H+ L + C G I+PP+ I S+ AS +K + K S+
Sbjct: 307 IHDDC----LQAVGHECDCGLLRDHILPPSSIYP------SVLASGPDRKNS----KTSQ 352
Query: 353 RGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQE 412
+ M+ N ++ P PLLVFVNPKSGG QG +VL F + LNPRQVF+L ++
Sbjct: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
Query: 413 GPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLN 472
GP+ L L++ VP+ RIL CGGDGTVGWIL +D+ L PPV VLPLGTGNDLAR L
Sbjct: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
Query: 473 WGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFS 532
WGGGY + ++KIL +E VV +DRW++ V P++ E+ +P + NNYFS
Sbjct: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEV------IPQQTEEKSDPVPFQIINNYFS 526
Query: 533 LGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTD 592
+G DA + FH RE PEKFNSR +NK++Y A S+ + + + L + + V G
Sbjct: 527 IGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKP 586
Query: 593 LTPKIQELKFQCIVFLNIPRYCAGTMPWGNP----GDHHDFEPQRH-------------- 634
L + L + I LNIP G+ WG+ GD +
Sbjct: 587 L--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKT 644
Query: 635 -----DDGYIEVIGFTMASLAALQVG-------GHGERLHQCREVMLLTYKSIPMQVDGE 682
D +EV+G A+++G G RL +C E+ T K++PMQ+DGE
Sbjct: 645 CVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGE 700
Query: 683 PCRLAPAMIRISLRNQANMVQKSKRRTS 710
P P I+I+ +NQ M+ R++
Sbjct: 701 PWMQTPCTIKITHKNQMPMLMGPPPRST 728
>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 286 bits (733), Expect = 6e-77
Identities = 193/568 (33%), Positives = 280/568 (49%), Gaps = 74/568 (13%)
Query: 175 NGEHLWLETNVSGDL-CYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCK 233
+G+H+W + C L E + + K L C +CK VH C +
Sbjct: 203 DGQHMWRPKRFPRPVYCNLCESS--IGLGKQGL--SCNLCKYTVHDQCA-------MKAL 251
Query: 234 PTFREGGSRSPRENFVRHH-WVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQA 292
P ++S ++ V+ H WV + G+C +C K + +HS + + C WC
Sbjct: 252 PCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIR---IYHS--LTGLHCVWCHLE 306
Query: 293 FHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASK 352
H+ L + C G I+PP+ I S+ AS +K + K S+
Sbjct: 307 IHDDC----LQAVGHECDCGLLRDHILPPSSIYP------SVLASGPDRKNS----KTSQ 352
Query: 353 RGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQE 412
+ M+ N ++ P PLLVFVNPKSGG QG +VL F + LNPRQVF+L ++
Sbjct: 353 KTMDDLNLSTSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKD 412
Query: 413 GPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLN 472
GP+ L L++ VP+ RIL CGGDGTVGWIL +D+ L PPV VLPLGTGNDLAR L
Sbjct: 413 GPEIGLRLFKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR 472
Query: 473 WGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFS 532
WGGGY + ++KIL +E VV +DRW++ V P++ E+ +P + NNYFS
Sbjct: 473 WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEV------IPQQTEEKSDPVPFQIINNYFS 526
Query: 533 LGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTD 592
+G DA + FH RE PEKFNSR +NK++Y A S+ + + + L + + V G
Sbjct: 527 IGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKP 586
Query: 593 LTPKIQELKFQCIVFLNIPRYCAGTMPWGNP----GDHHDFEPQRH-------------- 634
L + L + I LNIP G+ WG+ GD +
Sbjct: 587 L--DLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKT 644
Query: 635 -----DDGYIEVIGFTMASLAALQVG-------GHGERLHQCREVMLLTYKSIPMQVDGE 682
D +EV+G A+++G G RL +C E+ T K++PMQ+DGE
Sbjct: 645 CVPDLSDKRLEVVGLE----GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGE 700
Query: 683 PCRLAPAMIRISLRNQANMVQKSKRRTS 710
P P I+I+ +NQ M+ R++
Sbjct: 701 PWMQTPCTIKITHKNQMPMLMGPPPRST 728
>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
Length = 752
Score = 270 bits (691), Expect = 4e-72
Identities = 151/363 (41%), Positives = 206/363 (56%), Gaps = 27/363 (7%)
Query: 367 KPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPN 426
K I +P PLLV VNPKSGG QG ++L+ F + LNP+QVF+L GP L +R P+
Sbjct: 386 KIIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPD 445
Query: 427 LRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKIL 486
R+LACGGDGTVGWIL +D+ + PPV VLPLGTGNDLAR L WGGGY ++KIL
Sbjct: 446 FRVLACGGDGTVGWILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKIL 505
Query: 487 CQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHES 546
+E +V LDRW+L V +P EE+E+G ++P ++ NNYFS+G DA + FH
Sbjct: 506 KDIEQSPLVMLDRWHLEV-----IPREEVENG-DQVPYSIMNNYFSIGVDASIAHRFHVM 559
Query: 547 REANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIV 606
RE +PEKFNSR +NK++Y S+ + + L H+++ CDG + + + + I
Sbjct: 560 REKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVGV--DLSNIFLEGIA 617
Query: 607 FLNIPRYCAGTMPWGNPGDHH----------------DFEPQRHDDGYIEVIGFTMA-SL 649
LNIP GT WG + F Q D +EV+G A +
Sbjct: 618 ILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEM 677
Query: 650 AALQVG--GHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKR 707
+ G G RL QC V + T K +PMQVDGEP I+I+ +NQA M+ +
Sbjct: 678 GQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQ 737
Query: 708 RTS 710
++S
Sbjct: 738 KSS 740
>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
Length = 766
Score = 251 bits (642), Expect = 2e-66
Identities = 172/520 (33%), Positives = 238/520 (45%), Gaps = 86/520 (16%)
Query: 210 CAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKG 269
C CK VH C+ + C T+ S++ R V H KC +C K
Sbjct: 302 CTYCKYTVHERCVSRNIP---GCVKTY----SKAKRSGEVMQHAWVEGNSSVKCDRCHKS 354
Query: 270 FQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKK 329
+ S + A C WC+ FH K L C G I+ PT I + +
Sbjct: 355 IKCYQS-----VTARHCVWCRMTFHRKCELSTL------CDGGELRDHILLPTSICPITR 403
Query: 330 PQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQ 389
+ K+ + + K I +P PLLV VNPKSGG Q
Sbjct: 404 DRPGEKSDGCVSAKGELVMQ----------------YKIIPTPGTHPLLVLVNPKSGGRQ 447
Query: 390 GTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQ 449
G + L +R P+ R+LACGGDGTVGWIL +D+
Sbjct: 448 GER-------------------------LNFFRDTPDFRVLACGGDGTVGWILDCIDKAN 482
Query: 450 LSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPD 509
+ PPV VLPLGTGNDLAR L WGGGY ++KIL +E +V LDRW+L V
Sbjct: 483 FAKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKDIEQSPLVMLDRWHLEV----- 537
Query: 510 LPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAF 569
+P EE+E+G ++P ++ NNYFS+G DA + FH RE +PEKFNSR +NK++Y
Sbjct: 538 IPREEVENG-DQVPYSIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGT 596
Query: 570 SDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHH-- 627
S+ + + L H+++ CDG + + + + I LNIP GT WG +
Sbjct: 597 SETFAATCKKLHDHIELECDGVGV--DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAV 654
Query: 628 --------------DFEPQRHDDGYIEVIGFTMA-SLAALQVG--GHGERLHQCREVMLL 670
F Q D +EV+G A + + G G RL QC V +
Sbjct: 655 IRESRKGVTDPKELKFCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASVTIR 714
Query: 671 TYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTS 710
T K +PMQVDGEP I+I+ +NQA M+ +++S
Sbjct: 715 TNKLLPMQVDGEPWMQPCCTIKITHKNQAPMMMGPPQKSS 754
>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
Length = 567
Score = 231 bits (589), Expect = 3e-60
Identities = 175/567 (30%), Positives = 266/567 (46%), Gaps = 71/567 (12%)
Query: 177 EHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTF 236
+H W +T++ Y C + A C C + V C+ + +K F+CK
Sbjct: 59 KHGWRDTDLFSQPTYCCV--CAQHILQGAF---CDCCGLRVDEGCLRKADK-RFQCKEIM 112
Query: 237 REGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNK 296
+ ++ + + HHW+ R C C QQ ++ C WC++ H++
Sbjct: 113 LKNDTKVL--DAMPHHWI--RGNVPLCSYCMVCKQQCGC--QPKLCDYRCIWCQKTVHDE 166
Query: 297 VTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGME 356
C E C G +I+PP+++ + + RK K+T ++ ASK G +
Sbjct: 167 --CMKNSLKNEKCDFGEFKNLIIPPSYLTSINQM--------RKDKKTDYEVLASKLGKQ 216
Query: 357 QENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKD 416
PL++ N +SG N G +L F LNP QVFD+++ P
Sbjct: 217 -----------------WTPLIILANSRSGTNMGEGLLGEFRILLNPVQVFDVTKTPPIK 259
Query: 417 ALELYRKVP--NLRILACGGDGTVGWILSILDELQLSPQ----PPVGVLPLGTGNDLART 470
AL+L +P + R+L CGGDGTVGW+L +D++++ Q P V VLPLGTGNDL+ T
Sbjct: 260 ALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKIKGQEKYIPQVAVLPLGTGNDLSNT 319
Query: 471 LNWGGGYTDE-PVSKILCQVEDGTVVQLDRWNLHVERNPDL---PPEELEDGVCKLPLNV 526
L WG GY E PV+++L V + ++LDRW + V P+E
Sbjct: 320 LGWGTGYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEF----------T 369
Query: 527 FNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKV 586
NNYFS+G DA + L FH RE P F+SR NK Y D L + +DL+K V++
Sbjct: 370 MNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVEL 429
Query: 587 VCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIG-FT 645
DG ++ + I+ LNI + G W GD + RHDDG +EV+G +
Sbjct: 430 ELDG----ERVALPSLEGIIVLNIGYWGGGCRLWEGMGD-ETYPLARHDDGLLEVVGVYG 484
Query: 646 MASLAALQVG-GHGERLHQCREV-MLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQ 703
A +QV + R+ Q V ++L +PMQVDGEP P + I+ + A M+
Sbjct: 485 SFHCAQIQVKLANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMMLY 544
Query: 704 KSKRRTSMPLLNDPQSVPDRLRIRVNK 730
S +T +D S D+ I+ +
Sbjct: 545 FSGEQTD----DDISSTSDQEDIKATE 567
>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
Length = 942
Score = 223 bits (567), Expect = 1e-57
Identities = 134/341 (39%), Positives = 193/341 (56%), Gaps = 17/341 (4%)
Query: 376 PLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGD 435
PLLVFVNPKSGG +G +L F LNP QVFDL+ GP L L+ +VP R+L CGGD
Sbjct: 588 PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGD 647
Query: 436 GTVGWILSILDELQ---LSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDG 492
GTVGW+L L+E + P+P V +LPLGTGNDL R L WG GY+ E +L V++
Sbjct: 648 GTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLSVDEA 707
Query: 493 TVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNV-FNNYFSLGFDAHVTLEFHESREANP 551
V +DRW + ++ + + E + + P V +NY +G DA ++L+FH++RE P
Sbjct: 708 DAVLMDRWTILLDAH-EAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEP 766
Query: 552 EKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDL-TPKIQELKFQCIVFLNI 610
KF SR NK Y SR L K +++ + ++ P I+ L +F+NI
Sbjct: 767 GKFTSRLHNKGVYVRVGLQKI--SHSRSLHKQIRLQVERQEVELPSIEGL-----IFINI 819
Query: 611 PRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFT-MASLAALQVG-GHGERLHQCREVM 668
P + +G WG+ D FE R DDG +EV+G T + + +Q G G R+ Q
Sbjct: 820 PSWGSGADLWGSDSDTR-FEKPRMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFR 878
Query: 669 LLTYKSIPMQVDGEPCRLAPAMIRISLRN-QANMVQKSKRR 708
+ K+ P+QVDGEP AP + IS + +M++K+K++
Sbjct: 879 VTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQK 919
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 155 bits (393), Expect = 1e-37
Identities = 117/360 (32%), Positives = 158/360 (43%), Gaps = 56/360 (15%)
Query: 161 KEPRATLDWSENAVNGEHLWLE-TNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHT 219
+EP ++ +G H W ++ C + E+ ++ C VCK H
Sbjct: 159 REPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLS---GVTSHGLSCEVCKFKAHK 215
Query: 220 ACIEQLEKINFRCKPTFREGGSRSPREN----FVRHHWVHRRRQ-EGKCKQCGKGFQQKF 274
C + CK T + E+ + H W+ KC C K
Sbjct: 216 RCAVRATN---NCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVL 272
Query: 275 SFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSL 334
+ C WCK H C L+H C LG I+PP + NS
Sbjct: 273 RLQDWK-----CLWCKTMVHT--ACKDLYH--PICPLGQCKVSIIPPIAL-------NST 316
Query: 335 KASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVL 394
+ + SF + PLLVFVN KSG NQG K L
Sbjct: 317 DSDGFCRATFSF--------------------------CVSPLLVFVNSKSGDNQGVKFL 350
Query: 395 QMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQP 454
+ F LNP QVFDL GP L L++K N RIL CGGDG+VGW+LS +D+L L+ Q
Sbjct: 351 RRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQC 410
Query: 455 PVGVLPLGTGNDLARTLNWGGGYTDE-PVSKILCQVEDGTVVQLDRWNLHVERNPDLPPE 513
+GVLPLGTGNDLAR L WGG Y D+ + +IL ++E + LDRW++ + LPP+
Sbjct: 411 QLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSI-MTYELKLPPK 469
Score = 110 bits (275), Expect = 7e-24
Identities = 67/187 (35%), Positives = 99/187 (52%), Gaps = 12/187 (6%)
Query: 526 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVK 585
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + LQRS ++L + V+
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 586 VVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVI--- 642
+ CDG I Q I LNIP Y GT WG + F DD +EV+
Sbjct: 830 LECDG----QYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIF 885
Query: 643 -GFTMASLAALQVGGHGERLHQCREVMLLTY--KSIPMQVDGEPCRLAPAMIRISLRNQA 699
MA +++ H R+ QCR V + + + +P+QVDGE P +I+I +N+A
Sbjct: 886 DSMQMAVSRVIKLQHH--RIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRA 943
Query: 700 NMVQKSK 706
M+ + +
Sbjct: 944 QMLTRDR 950
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 155 bits (393), Expect = 1e-37
Identities = 117/360 (32%), Positives = 158/360 (43%), Gaps = 56/360 (15%)
Query: 161 KEPRATLDWSENAVNGEHLWLE-TNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHT 219
+EP ++ +G H W ++ C + E+ ++ C VCK H
Sbjct: 159 REPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLS---GVTSHGLSCEVCKFKAHK 215
Query: 220 ACIEQLEKINFRCKPTFREGGSRSPREN----FVRHHWVHRRRQ-EGKCKQCGKGFQQKF 274
C + CK T + E+ + H W+ KC C K
Sbjct: 216 RCAVRATN---NCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVL 272
Query: 275 SFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSL 334
+ C WCK H C L+H C LG I+PP + NS
Sbjct: 273 RLQDWK-----CLWCKTMVHT--ACKDLYH--PICPLGQCKVSIIPPIAL-------NST 316
Query: 335 KASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVL 394
+ + SF + PLLVFVN KSG NQG K L
Sbjct: 317 DSDGFCRATFSF--------------------------CVSPLLVFVNSKSGDNQGVKFL 350
Query: 395 QMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQP 454
+ F LNP QVFDL GP L L++K N RIL CGGDG+VGW+LS +D+L L+ Q
Sbjct: 351 RRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQC 410
Query: 455 PVGVLPLGTGNDLARTLNWGGGYTDE-PVSKILCQVEDGTVVQLDRWNLHVERNPDLPPE 513
+GVLPLGTGNDLAR L WGG Y D+ + +IL ++E + LDRW++ + LPP+
Sbjct: 411 QLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSI-MTYELKLPPK 469
Score = 110 bits (275), Expect = 7e-24
Identities = 67/187 (35%), Positives = 99/187 (52%), Gaps = 12/187 (6%)
Query: 526 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVK 585
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + LQRS ++L + V+
Sbjct: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
Query: 586 VVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVI--- 642
+ CDG I Q I LNIP Y GT WG + F DD +EV+
Sbjct: 830 LECDG----QYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIF 885
Query: 643 -GFTMASLAALQVGGHGERLHQCREVMLLTY--KSIPMQVDGEPCRLAPAMIRISLRNQA 699
MA +++ H R+ QCR V + + + +P+QVDGE P +I+I +N+A
Sbjct: 886 DSMQMAVSRVIKLQHH--RIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRA 943
Query: 700 NMVQKSK 706
M+ + +
Sbjct: 944 QMLTRDR 950
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 142 bits (358), Expect = 2e-33
Identities = 101/299 (33%), Positives = 127/299 (42%), Gaps = 50/299 (16%)
Query: 210 CAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENF----VRHHWVHRRRQ-EGKCK 264
C VCK H C + CK T + E+ + H W+ KC
Sbjct: 150 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 206
Query: 265 QCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWI 324
C K C WCK H +L C LG ++PPT +
Sbjct: 207 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLL----TKCPLGLCKVSVIPPTAL 257
Query: 325 IKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPK 384
NS+ + F PLLVFVN K
Sbjct: 258 -------NSIDSDG-------------------------FWKASCPPSCTSPLLVFVNSK 285
Query: 385 SGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSI 444
SG NQG K L+ F LNP QVFDL GP L L++K RIL CGGDG+VGW+LS
Sbjct: 286 SGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSE 345
Query: 445 LDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDE-PVSKILCQVEDGTVVQLDRWNL 502
+D L L Q +GVLPLGTGNDLAR L WG D+ + +IL ++E + LDRW++
Sbjct: 346 IDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSV 404
Score = 103 bits (257), Expect = 9e-22
Identities = 63/188 (33%), Positives = 98/188 (52%), Gaps = 14/188 (7%)
Query: 526 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVK 585
V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L R+ ++L + V
Sbjct: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
Query: 586 VVCDGTDL-TPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVI-- 642
+ CDG + P +Q I LNIP Y GT WG + F DD +EV+
Sbjct: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833
Query: 643 --GFTMASLAALQVGGHGERLHQCR--EVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQ 698
MA +++ H R+ QCR ++ +L + +P+QVDGE P IRI +N+
Sbjct: 834 FGSMQMAVSRVIRLQHH--RIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNR 891
Query: 699 ANMVQKSK 706
A + + +
Sbjct: 892 AQTLTRDR 899
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 142 bits (358), Expect = 2e-33
Identities = 101/299 (33%), Positives = 127/299 (42%), Gaps = 50/299 (16%)
Query: 210 CAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENF----VRHHWVHRRRQ-EGKCK 264
C VCK H C + CK T + E+ + H W+ KC
Sbjct: 194 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 250
Query: 265 QCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWI 324
C K C WCK H +L C LG ++PPT +
Sbjct: 251 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLL----TKCPLGLCKVSVIPPTAL 301
Query: 325 IKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPK 384
NS+ + F PLLVFVN K
Sbjct: 302 -------NSIDSDG-------------------------FWKASCPPSCTSPLLVFVNSK 329
Query: 385 SGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSI 444
SG NQG K L+ F LNP QVFDL GP L L++K RIL CGGDG+VGW+LS
Sbjct: 330 SGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSE 389
Query: 445 LDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDE-PVSKILCQVEDGTVVQLDRWNL 502
+D L L Q +GVLPLGTGNDLAR L WG D+ + +IL ++E + LDRW++
Sbjct: 390 IDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSV 448
Score = 103 bits (257), Expect = 9e-22
Identities = 63/188 (33%), Positives = 98/188 (52%), Gaps = 14/188 (7%)
Query: 526 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVK 585
V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L R+ ++L + V
Sbjct: 763 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 822
Query: 586 VVCDGTDL-TPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVI-- 642
+ CDG + P +Q I LNIP Y GT WG + F DD +EV+
Sbjct: 823 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 877
Query: 643 --GFTMASLAALQVGGHGERLHQCR--EVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQ 698
MA +++ H R+ QCR ++ +L + +P+QVDGE P IRI +N+
Sbjct: 878 FGSMQMAVSRVIRLQHH--RIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNR 935
Query: 699 ANMVQKSK 706
A + + +
Sbjct: 936 AQTLTRDR 943
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 136 bits (342), Expect = 1e-31
Identities = 91/304 (29%), Positives = 133/304 (43%), Gaps = 34/304 (11%)
Query: 210 CAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKG 269
C VCK+ H C + K + + E + H WV QC
Sbjct: 358 CEVCKVKSHRLCALRASKDCKWNTLSITDDLLLPADEVNMPHQWVEGNMPVSS--QCAVC 415
Query: 270 FQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKK 329
+ S+ + + C WC H+ + C +H + ++PPT + K
Sbjct: 416 HESCGSY--QRLQDFRCLWCNSTVHDDCR----RRFSKECCFRSHRSSVIPPTALSDPKG 469
Query: 330 PQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQ 389
+ +S+ F SS PLL+F+N KSG +Q
Sbjct: 470 DGQLVVSSD-------------------------FWNLDWSSACSCPLLIFINSKSGDHQ 504
Query: 390 GTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQ 449
G L+ F YLNP QVFDL + GP+ L +++ RIL CGGDG+V W+LS++D
Sbjct: 505 GIVFLRKFKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWVLSLIDAFG 564
Query: 450 LSPQPPVGVLPLGTGNDLARTLNWGGGYT-DEPVSKILCQVEDGTVVQLDRWNLHVERNP 508
L + + V+PLGTGNDLAR L WG + + IL +VE +V LDRW++ + P
Sbjct: 565 LHEKCQLAVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRILDRWSVMIRETP 624
Query: 509 DLPP 512
P
Sbjct: 625 RQTP 628
Score = 115 bits (287), Expect = 3e-25
Identities = 67/186 (36%), Positives = 102/186 (54%), Gaps = 10/186 (5%)
Query: 526 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVK 585
V NNYF +G DA ++L+F+ R+ +P ++NSR +NKM+Y + LQRS R L + V
Sbjct: 857 VMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVH 916
Query: 586 VVCDGTDLT-PKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGF 644
+ CDG ++ P +Q IV LNI Y G WG+ ++E DDG +EV+
Sbjct: 917 LECDGETISLPNLQG-----IVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAI 971
Query: 645 TMASLAALQ--VGGHGERLHQCREVMLLT--YKSIPMQVDGEPCRLAPAMIRISLRNQAN 700
+ A+ + H R+ QC EVM+ + IP+QVDGE P +I+I +N A
Sbjct: 972 FGSVQMAMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAAQ 1031
Query: 701 MVQKSK 706
M+ + +
Sbjct: 1032 MLTRDR 1037
>gi|122937319 even-skipped homeobox 2 [Homo sapiens]
Length = 476
Score = 59.3 bits (142), Expect = 2e-08
Identities = 43/125 (34%), Positives = 55/125 (44%), Gaps = 12/125 (9%)
Query: 3 AAGRGCHLLPLPAARGPARAPAAAAAAAASPPG---PCSGAACAPSAAAGAGAMNPSSSA 59
AAG AA A A ++AAAA A P G PCS +C S +A A A +++
Sbjct: 350 AAGLNSAASAAAAAAAAAAAASSAAAAGAPPSGGSAPCSCLSCHSSQSAAAAAAAAAAAL 409
Query: 60 GEEKGATGGSSSSGSGAGSCCLGAEGGAD-------PRGAGSAAAAGAAALDEPAAAGQK 112
G G GG G G G GA GG+D PR AA L + A +
Sbjct: 410 GSRGGGGGGGGGGGGGGGGA--GAGGGSDFGCSAAAPRSESGFLPYSAAVLSKTAVSPPD 467
Query: 113 EKDEA 117
++DEA
Sbjct: 468 QRDEA 472
Score = 33.1 bits (74), Expect = 1.4
Identities = 25/85 (29%), Positives = 37/85 (43%), Gaps = 4/85 (4%)
Query: 19 PARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAG-EEKGATGGSSSSGSGAG 77
P AAA A S +A GA + ++ G E G+ G+++S SG+G
Sbjct: 102 PGHYSEAAAEADMSSDVEVGCSALRSPGGLGAAQLKENNGKGYAESGSAAGTTTSASGSG 161
Query: 78 SCCLGAEGGADPRGAGSAAAAGAAA 102
LG+ G GSAA G+ +
Sbjct: 162 ---LGSLHGGSGGSGGSAALGGSGS 183
Score = 30.4 bits (67), Expect = 9.3
Identities = 39/132 (29%), Positives = 48/132 (36%), Gaps = 53/132 (40%)
Query: 20 ARAPAAAAAAAASPPGPCS--------------------------GAACAPSAAAGAGAM 53
A A A+ AAAAAS P S G AP+AAAG +
Sbjct: 297 AAAAASGAAAAASSPFATSIRPLDTFRALSHPYSRPELLCSFRHPGLYQAPAAAAG---L 353
Query: 54 NPSSSAGEEKGATGGSSSSGSGAGSCCLGAEGGADPRG---------------AGSAAAA 98
N ++SA A ++SS + AG A P G A +AAAA
Sbjct: 354 NSAASAAAAAAAAAAAASSAAAAG---------APPSGGSAPCSCLSCHSSQSAAAAAAA 404
Query: 99 GAAALDEPAAAG 110
AAAL G
Sbjct: 405 AAAALGSRGGGG 416
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 4/142 (2%)
Query: 907 DSDLKDLSHSRVLQSPVSSEDHA-ILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHY 965
DS K S+ + P S+ +A L+A AG+L K++E K G + + + LH
Sbjct: 11 DSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHL 70
Query: 966 AAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTD 1025
AAK G+ +V+ +L G S +D A ++ G TALH A+ V ++LV GA++
Sbjct: 71 AAKEGHVGLVQELLGRGSS--VDSA-TKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 1026 SKGKTPQERAQQAGDPDLAAYL 1047
G TP A Q D+ YL
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYL 149
Score = 44.3 bits (103), Expect = 6e-04
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 3/123 (2%)
Query: 929 AILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLD 988
A+ A AG + + +NG + + + + LH A++ G EIV+ +L H
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP--- 523
Query: 989 MADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLE 1048
A + G T LH +A + V +L++AGA+ KG TP A + G D+A L
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 1049 SRQ 1051
R+
Sbjct: 584 QRR 586
Score = 41.2 bits (95), Expect = 0.005
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 7/87 (8%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADS--ETGETALHKAACQRNRAVCQLLVDAGAS 1020
LH AAK G+ ++ K +L + ADS + G T LH AA N+ V LL++ GAS
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAA-----ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 1021 LRKTDSKGKTPQERAQQAGDPDLAAYL 1047
T G TP A + +A+ L
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTL 648
Score = 39.7 bits (91), Expect = 0.015
Identities = 28/75 (37%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 958 DHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRA-VCQLLVD 1016
D+ + LH AA G+ + K +LD + A + G T LH AC++NR V +LLV
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLH-IACKKNRIKVMELLVK 419
Query: 1017 AGASLRKTDSKGKTP 1031
GAS++ G TP
Sbjct: 420 YGASIQAITESGLTP 434
Score = 37.0 bits (84), Expect = 0.099
Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 3/88 (3%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLR 1022
LH AA GN + +L+ G + +D + G T LH A+ + N + +LL+D G +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAA--VDFT-ARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
Query: 1023 KTDSKGKTPQERAQQAGDPDLAAYLESR 1050
G TP A ++G + L R
Sbjct: 294 AKTRDGLTPLHCAARSGHDQVVELLLER 321
Score = 37.0 bits (84), Expect = 0.099
Identities = 25/85 (29%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLR 1022
LH A K ++++ ++ +G S A +E+G T +H AA + + LL+ GAS
Sbjct: 402 LHIACKKNRIKVMELLVKYGASI---QAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 1023 KTDSKGKTPQERAQQAGDPDLAAYL 1047
T+ +G+T A +AG ++ L
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCL 483
Score = 36.6 bits (83), Expect = 0.13
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 5/93 (5%)
Query: 963 LHYAAKTGNGEIVKYIL--DHGP---SELLDMADSETGETALHKAACQRNRAVCQLLVDA 1017
LH AA+ + + +L DH S+++ +E+G T LH AA N V LL++
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 1018 GASLRKTDSKGKTPQERAQQAGDPDLAAYLESR 1050
GA++ T G TP A + G+ ++ L R
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Score = 34.3 bits (77), Expect = 0.64
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLR 1022
LH AAK +I +L++G + ++ G T LH A+ + + + LL+D GA++
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIV---TKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 1023 KTDSKGKTPQERAQQAGDPDLAAYL 1047
+ G T A Q ++A L
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 34.3 bits (77), Expect = 0.64
Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 9/94 (9%)
Query: 966 AAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTD 1025
A GN ++V ++L G + A ++ G T LH+AA Q + + +L+ GA T
Sbjct: 735 ACHYGNVKMVNFLLKQGANV---NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791
Query: 1026 SKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHE 1059
+ G T A++ G Y+ KV+ E
Sbjct: 792 ANGNTALAIAKRLG------YISVVDTLKVVTEE 819
Score = 33.9 bits (76), Expect = 0.84
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 5/109 (4%)
Query: 939 LMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETA 998
+M+L+ Y G S+ + +H AA G+ IV +L +G S D+ + GETA
Sbjct: 413 VMELLVKY--GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP--DVTNIR-GETA 467
Query: 999 LHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYL 1047
LH AA V + L+ GA + + +TP A + G ++ L
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/118 (27%), Positives = 55/118 (46%), Gaps = 12/118 (10%)
Query: 913 LSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNG 972
L + S + A+ A +AG + K G ++ Q + + L+ AA+ +
Sbjct: 84 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Query: 973 EIVKYILDHGPSELLDMADSETGETALHKAACQ-RNRAVCQLLVDAGASLRKTDSKGK 1029
++VKY+L++G ++ +E G T L A Q N+AV LL + D+KGK
Sbjct: 144 DVVKYLLENGANQ---STATEDGFTPLAVALQQGHNQAVAILL--------ENDTKGK 190
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 4/142 (2%)
Query: 907 DSDLKDLSHSRVLQSPVSSEDHA-ILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHY 965
DS K S+ + P S+ +A L+A AG+L K++E K G + + + LH
Sbjct: 11 DSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHL 70
Query: 966 AAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTD 1025
AAK G+ +V+ +L G S +D A ++ G TALH A+ V ++LV GA++
Sbjct: 71 AAKEGHVGLVQELLGRGSS--VDSA-TKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 1026 SKGKTPQERAQQAGDPDLAAYL 1047
G TP A Q D+ YL
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYL 149
Score = 44.3 bits (103), Expect = 6e-04
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 3/123 (2%)
Query: 929 AILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLD 988
A+ A AG + + +NG + + + + LH A++ G EIV+ +L H
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP--- 523
Query: 989 MADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLE 1048
A + G T LH +A + V +L++AGA+ KG TP A + G D+A L
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 1049 SRQ 1051
R+
Sbjct: 584 QRR 586
Score = 41.2 bits (95), Expect = 0.005
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 7/87 (8%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADS--ETGETALHKAACQRNRAVCQLLVDAGAS 1020
LH AAK G+ ++ K +L + ADS + G T LH AA N+ V LL++ GAS
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAA-----ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 1021 LRKTDSKGKTPQERAQQAGDPDLAAYL 1047
T G TP A + +A+ L
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTL 648
Score = 39.7 bits (91), Expect = 0.015
Identities = 28/75 (37%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 958 DHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRA-VCQLLVD 1016
D+ + LH AA G+ + K +LD + A + G T LH AC++NR V +LLV
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLH-IACKKNRIKVMELLVK 419
Query: 1017 AGASLRKTDSKGKTP 1031
GAS++ G TP
Sbjct: 420 YGASIQAITESGLTP 434
Score = 37.0 bits (84), Expect = 0.099
Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 3/88 (3%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLR 1022
LH AA GN + +L+ G + +D + G T LH A+ + N + +LL+D G +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAA--VDFT-ARNGITPLHVASKRGNTNMVKLLLDRGGQID 293
Query: 1023 KTDSKGKTPQERAQQAGDPDLAAYLESR 1050
G TP A ++G + L R
Sbjct: 294 AKTRDGLTPLHCAARSGHDQVVELLLER 321
Score = 37.0 bits (84), Expect = 0.099
Identities = 25/85 (29%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLR 1022
LH A K ++++ ++ +G S A +E+G T +H AA + + LL+ GAS
Sbjct: 402 LHIACKKNRIKVMELLVKYGASI---QAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 1023 KTDSKGKTPQERAQQAGDPDLAAYL 1047
T+ +G+T A +AG ++ L
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCL 483
Score = 36.6 bits (83), Expect = 0.13
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 5/93 (5%)
Query: 963 LHYAAKTGNGEIVKYIL--DHGP---SELLDMADSETGETALHKAACQRNRAVCQLLVDA 1017
LH AA+ + + +L DH S+++ +E+G T LH AA N V LL++
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 1018 GASLRKTDSKGKTPQERAQQAGDPDLAAYLESR 1050
GA++ T G TP A + G+ ++ L R
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Score = 34.3 bits (77), Expect = 0.64
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLR 1022
LH AAK +I +L++G + ++ G T LH A+ + + + LL+D GA++
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIV---TKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Query: 1023 KTDSKGKTPQERAQQAGDPDLAAYL 1047
+ G T A Q ++A L
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 34.3 bits (77), Expect = 0.64
Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 9/94 (9%)
Query: 966 AAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTD 1025
A GN ++V ++L G + A ++ G T LH+AA Q + + +L+ GA T
Sbjct: 735 ACHYGNVKMVNFLLKQGANV---NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791
Query: 1026 SKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHE 1059
+ G T A++ G Y+ KV+ E
Sbjct: 792 ANGNTALAIAKRLG------YISVVDTLKVVTEE 819
Score = 33.9 bits (76), Expect = 0.84
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 5/109 (4%)
Query: 939 LMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETA 998
+M+L+ Y G S+ + +H AA G+ IV +L +G S D+ + GETA
Sbjct: 413 VMELLVKY--GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP--DVTNIR-GETA 467
Query: 999 LHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYL 1047
LH AA V + L+ GA + + +TP A + G ++ L
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/118 (27%), Positives = 55/118 (46%), Gaps = 12/118 (10%)
Query: 913 LSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNG 972
L + S + A+ A +AG + K G ++ Q + + L+ AA+ +
Sbjct: 84 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Query: 973 EIVKYILDHGPSELLDMADSETGETALHKAACQ-RNRAVCQLLVDAGASLRKTDSKGK 1029
++VKY+L++G ++ +E G T L A Q N+AV LL + D+KGK
Sbjct: 144 DVVKYLLENGANQ---STATEDGFTPLAVALQQGHNQAVAILL--------ENDTKGK 190
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 57.4 bits (137), Expect = 7e-08
Identities = 41/124 (33%), Positives = 63/124 (50%), Gaps = 3/124 (2%)
Query: 924 SSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGP 983
S + + L+A AG+L K++E K G + + + LH AAK G+ +V+ +L G
Sbjct: 8 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67
Query: 984 SELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDL 1043
S +D A ++ G TALH A+ V ++LV GA++ G TP A Q D+
Sbjct: 68 S--VDSA-TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDV 124
Query: 1044 AAYL 1047
YL
Sbjct: 125 VKYL 128
Score = 44.3 bits (103), Expect = 6e-04
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 3/123 (2%)
Query: 929 AILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLD 988
A+ A AG + + +NG + + + + LH A++ G EIV+ +L H
Sbjct: 446 ALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHP--- 502
Query: 989 MADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLE 1048
A + G T LH +A + V +L++AGA+ KG TP A + G D+A L
Sbjct: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
Query: 1049 SRQ 1051
R+
Sbjct: 563 QRR 565
Score = 41.2 bits (95), Expect = 0.005
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 7/87 (8%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADS--ETGETALHKAACQRNRAVCQLLVDAGAS 1020
LH AAK G+ ++ K +L + ADS + G T LH AA N+ V LL++ GAS
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAA-----ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600
Query: 1021 LRKTDSKGKTPQERAQQAGDPDLAAYL 1047
T G TP A + +A+ L
Sbjct: 601 PHATAKNGYTPLHIAAKKNQMQIASTL 627
Score = 39.7 bits (91), Expect = 0.015
Identities = 28/75 (37%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 958 DHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRA-VCQLLVD 1016
D+ + LH AA G+ + K +LD + A + G T LH AC++NR V +LLV
Sbjct: 343 DYLTALHVAAHCGHYRVTKLLLDKRANP---NARALNGFTPLH-IACKKNRIKVMELLVK 398
Query: 1017 AGASLRKTDSKGKTP 1031
GAS++ G TP
Sbjct: 399 YGASIQAITESGLTP 413
Score = 37.0 bits (84), Expect = 0.099
Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 3/88 (3%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLR 1022
LH AA GN + +L+ G + +D + G T LH A+ + N + +LL+D G +
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAA--VDFT-ARNGITPLHVASKRGNTNMVKLLLDRGGQID 272
Query: 1023 KTDSKGKTPQERAQQAGDPDLAAYLESR 1050
G TP A ++G + L R
Sbjct: 273 AKTRDGLTPLHCAARSGHDQVVELLLER 300
Score = 37.0 bits (84), Expect = 0.099
Identities = 25/85 (29%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLR 1022
LH A K ++++ ++ +G S A +E+G T +H AA + + LL+ GAS
Sbjct: 381 LHIACKKNRIKVMELLVKYGASI---QAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437
Query: 1023 KTDSKGKTPQERAQQAGDPDLAAYL 1047
T+ +G+T A +AG ++ L
Sbjct: 438 VTNIRGETALHMAARAGQVEVVRCL 462
Score = 36.6 bits (83), Expect = 0.13
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 5/93 (5%)
Query: 963 LHYAAKTGNGEIVKYIL--DHGP---SELLDMADSETGETALHKAACQRNRAVCQLLVDA 1017
LH AA+ + + +L DH S+++ +E+G T LH AA N V LL++
Sbjct: 175 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 234
Query: 1018 GASLRKTDSKGKTPQERAQQAGDPDLAAYLESR 1050
GA++ T G TP A + G+ ++ L R
Sbjct: 235 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 267
Score = 34.3 bits (77), Expect = 0.64
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Query: 963 LHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLR 1022
LH AAK +I +L++G + ++ G T LH A+ + + + LL+D GA++
Sbjct: 612 LHIAAKKNQMQIASTLLNYGAETNIV---TKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668
Query: 1023 KTDSKGKTPQERAQQAGDPDLAAYL 1047
+ G T A Q ++A L
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADIL 693
Score = 34.3 bits (77), Expect = 0.64
Identities = 26/94 (27%), Positives = 43/94 (45%), Gaps = 9/94 (9%)
Query: 966 AAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTD 1025
A GN ++V ++L G + A ++ G T LH+AA Q + + +L+ GA T
Sbjct: 714 ACHYGNVKMVNFLLKQGANV---NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 770
Query: 1026 SKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHE 1059
+ G T A++ G Y+ KV+ E
Sbjct: 771 ANGNTALAIAKRLG------YISVVDTLKVVTEE 798
Score = 33.9 bits (76), Expect = 0.84
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 5/109 (4%)
Query: 939 LMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETA 998
+M+L+ Y G S+ + +H AA G+ IV +L +G S D+ + GETA
Sbjct: 392 VMELLVKY--GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP--DVTNIR-GETA 446
Query: 999 LHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYL 1047
LH AA V + L+ GA + + +TP A + G ++ L
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/118 (27%), Positives = 55/118 (46%), Gaps = 12/118 (10%)
Query: 913 LSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNG 972
L + S + A+ A +AG + K G ++ Q + + L+ AA+ +
Sbjct: 63 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 122
Query: 973 EIVKYILDHGPSELLDMADSETGETALHKAACQ-RNRAVCQLLVDAGASLRKTDSKGK 1029
++VKY+L++G ++ +E G T L A Q N+AV LL + D+KGK
Sbjct: 123 DVVKYLLENGANQ---STATEDGFTPLAVALQQGHNQAVAILL--------ENDTKGK 169
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapiens]
Length = 1771
Score = 55.5 bits (132), Expect = 3e-07
Identities = 41/126 (32%), Positives = 60/126 (47%), Gaps = 3/126 (2%)
Query: 922 PVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDH 981
P S D ++ AV G + + + + I+G D+ + L++A + GN +V+ IL
Sbjct: 265 PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQC 324
Query: 982 GPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDP 1041
P + D GET L KA RN V +LL+D GA + D KG TP A +
Sbjct: 325 NPDTEICTKD---GETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSR 381
Query: 1042 DLAAYL 1047
LA L
Sbjct: 382 KLAELL 387
Score = 34.7 bits (78), Expect = 0.49
Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 3/111 (2%)
Query: 955 QGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLL 1014
+G + + L A K G + VK IL P+ +++ D + G TAL A+ + + + Q L
Sbjct: 199 EGANSMTALIVAVKGGYTQSVKEILKRNPN--VNLTDKD-GNTALMIASKEGHTEIVQDL 255
Query: 1015 VDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV 1065
+DAG + D G T A + G ++ L + I +D +TA+
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTAL 306
Score = 31.2 bits (69), Expect = 5.4
Identities = 35/119 (29%), Positives = 54/119 (45%), Gaps = 5/119 (4%)
Query: 930 ILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPS-ELLD 988
++ A G+L + E KNG + ++ D+ + L A+K G+ IV+ +L G + E D
Sbjct: 42 LMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRD 101
Query: 989 MADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYL 1047
M G TAL A + V +LL+ GA+ T P A G D+ L
Sbjct: 102 MG----GWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156
>gi|73427806 v-maf musculoaponeurotic fibrosarcoma oncogene homolog
isoform b [Homo sapiens]
Length = 373
Score = 53.9 bits (128), Expect = 8e-07
Identities = 48/147 (32%), Positives = 63/147 (42%), Gaps = 18/147 (12%)
Query: 4 AGRGCHLLPLPAARGPARAPAAA---AAAAASPPGP--------CSGAACAPSAAAGAGA 52
AG G L GPA A +A AAAA S GP +G P+A A A
Sbjct: 144 AGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAGPHYHHHHHHAAGHHHHPTAGAPGAA 203
Query: 53 MNPSSSAGEEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQK 112
+ ++SAG GA GG +S G G GG G G AA AG A AA G
Sbjct: 204 GSAAASAGGAGGAGGGGPASAGGGG-------GGGGGGGGGGAAGAGGALHPHHAAGGLH 256
Query: 113 EKDEALEEKLRNLTFRKQVSYRKAISR 139
D +E+L ++ R+ + +S+
Sbjct: 257 FDDRFSDEQLVTMSVRELNRQLRGVSK 283
>gi|5453736 v-maf musculoaponeurotic fibrosarcoma oncogene homolog
isoform a [Homo sapiens]
Length = 403
Score = 53.9 bits (128), Expect = 8e-07
Identities = 48/147 (32%), Positives = 63/147 (42%), Gaps = 18/147 (12%)
Query: 4 AGRGCHLLPLPAARGPARAPAAA---AAAAASPPGP--------CSGAACAPSAAAGAGA 52
AG G L GPA A +A AAAA S GP +G P+A A A
Sbjct: 144 AGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAGPHYHHHHHHAAGHHHHPTAGAPGAA 203
Query: 53 MNPSSSAGEEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQK 112
+ ++SAG GA GG +S G G GG G G AA AG A AA G
Sbjct: 204 GSAAASAGGAGGAGGGGPASAGGGG-------GGGGGGGGGGAAGAGGALHPHHAAGGLH 256
Query: 113 EKDEALEEKLRNLTFRKQVSYRKAISR 139
D +E+L ++ R+ + +S+
Sbjct: 257 FDDRFSDEQLVTMSVRELNRQLRGVSK 283
>gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 52.8 bits (125), Expect = 2e-06
Identities = 38/118 (32%), Positives = 60/118 (50%), Gaps = 4/118 (3%)
Query: 931 LQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMA 990
LQ ++ G +E K G S +Q S +H AA+TG + +K +++HG +++
Sbjct: 46 LQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGAD--VNVP 103
Query: 991 DSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLE 1048
D TG +H A + + AV L A + L + D++G TP E A Q G DL L+
Sbjct: 104 DG-TGALPIHLAVQEGHTAVVSFLA-AESDLHRRDARGLTPLELALQRGAQDLVDILQ 159
>gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 52.8 bits (125), Expect = 2e-06
Identities = 38/118 (32%), Positives = 60/118 (50%), Gaps = 4/118 (3%)
Query: 931 LQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMA 990
LQ ++ G +E K G S +Q S +H AA+TG + +K +++HG +++
Sbjct: 46 LQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGAD--VNVP 103
Query: 991 DSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLE 1048
D TG +H A + + AV L A + L + D++G TP E A Q G DL L+
Sbjct: 104 DG-TGALPIHLAVQEGHTAVVSFLA-AESDLHRRDARGLTPLELALQRGAQDLVDILQ 159
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,904,172
Number of Sequences: 37866
Number of extensions: 2380764
Number of successful extensions: 31220
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 740
Number of HSP's successfully gapped in prelim test: 982
Number of HSP's that attempted gapping in prelim test: 16124
Number of HSP's gapped (non-prelim): 11703
length of query: 1065
length of database: 18,247,518
effective HSP length: 113
effective length of query: 952
effective length of database: 13,968,660
effective search space: 13298164320
effective search space used: 13298164320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.