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Search of human proteins with 4757722
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4757722 ADAM metallopeptidase domain 22 isoform 4
preproprotein [Homo sapiens]
(859 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 1801 0.0
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 1801 0.0
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 1710 0.0
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 1710 0.0
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 1710 0.0
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s... 849 0.0
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 754 0.0
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 372 e-102
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 370 e-102
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 368 e-101
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 328 1e-89
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 327 2e-89
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 313 6e-85
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 313 6e-85
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 313 6e-85
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 313 6e-85
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 313 6e-85
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 313 6e-85
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 311 1e-84
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 307 2e-83
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 286 6e-77
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 281 1e-75
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 277 3e-74
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 267 3e-71
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 258 1e-68
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 258 1e-68
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 258 1e-68
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 258 1e-68
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 253 5e-67
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 251 2e-66
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 1801 bits (4666), Expect = 0.0
Identities = 859/859 (100%), Positives = 859/859 (100%)
Query: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
Query: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD 780
AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD 780
Query: 781 GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 840
GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG
Sbjct: 781 GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 840
Query: 841 GNKKKIRGKRFRPRSNSTE 859
GNKKKIRGKRFRPRSNSTE
Sbjct: 841 GNKKKIRGKRFRPRSNSTE 859
>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
[Homo sapiens]
Length = 859
Score = 1801 bits (4666), Expect = 0.0
Identities = 859/859 (100%), Positives = 859/859 (100%)
Query: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
Query: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD 780
AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD 780
Query: 781 GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 840
GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG
Sbjct: 781 GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 840
Query: 841 GNKKKIRGKRFRPRSNSTE 859
GNKKKIRGKRFRPRSNSTE
Sbjct: 841 GNKKKIRGKRFRPRSNSTE 859
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 1710 bits (4429), Expect = 0.0
Identities = 823/859 (95%), Positives = 823/859 (95%), Gaps = 36/859 (4%)
Query: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
Query: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD 780
AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ-------------- 766
Query: 781 GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 840
RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG
Sbjct: 767 ----------------------RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 804
Query: 841 GNKKKIRGKRFRPRSNSTE 859
GNKKKIRGKRFRPRSNSTE
Sbjct: 805 GNKKKIRGKRFRPRSNSTE 823
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 1710 bits (4429), Expect = 0.0
Identities = 823/859 (95%), Positives = 823/859 (95%), Gaps = 36/859 (4%)
Query: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
Query: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD 780
AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ-------------- 766
Query: 781 GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 840
RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG
Sbjct: 767 ----------------------RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 804
Query: 841 GNKKKIRGKRFRPRSNSTE 859
GNKKKIRGKRFRPRSNSTE
Sbjct: 805 GNKKKIRGKRFRPRSNSTE 823
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 1710 bits (4429), Expect = 0.0
Identities = 823/859 (95%), Positives = 823/859 (95%), Gaps = 36/859 (4%)
Query: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1 MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
Query: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61 GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD 780
AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ-------------- 766
Query: 781 GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 840
RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG
Sbjct: 767 ----------------------RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 804
Query: 841 GNKKKIRGKRFRPRSNSTE 859
GNKKKIRGKRFRPRSNSTE
Sbjct: 805 GNKKKIRGKRFRPRSNSTE 823
>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
Length = 769
Score = 849 bits (2194), Expect = 0.0
Identities = 405/721 (56%), Positives = 514/721 (71%), Gaps = 10/721 (1%)
Query: 52 PLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLL 111
P RL+ S G E R LDTRVR + G H+ Q SF + AF ++F LD+ LNH LL
Sbjct: 50 PSRLVRESSG-GEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLL 108
Query: 112 SSEYIERHIEHGGKTVEVKG-GEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLI 170
SS+Y+ERH G T G G+HCYYQG +RGNP SF ALSTC GLHG+F DGN TY++
Sbjct: 109 SSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIV 168
Query: 171 EPEENDT---TQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPK-RSKRQ 226
EP+E + H +Y++ L L E + P++ RP+ R KRQ
Sbjct: 169 EPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGC--REPGCLFAVPAQSAPPNRPRLRRKRQ 226
Query: 227 LRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIV 286
+RR V ETKY+EL+++NDH +F++ R SVV T+ +AKSVVN+AD+IYK+QL TRIV
Sbjct: 227 VRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIV 286
Query: 287 LVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG 346
LVAMETWA +K + ++ L TL M YRR+ + E SDA HLFSG F+S+ SGAAY+G
Sbjct: 287 LVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVG 346
Query: 347 GICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDT 406
GICSL GGGVNE+G MAVTLAQ+L N+G++ +K + ++G+CKC D W GCIM DT
Sbjct: 347 GICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDT 406
Query: 407 GYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAEC 466
G+YLP+KF++C+I+EY+ FL GGG+CLFNKP KLLDPPECGNGF+E GEECDCG+ EC
Sbjct: 407 GFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQEC 466
Query: 467 VLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPN 526
G CCKKCTLT D+ CSDGLCC++CK++P G CREAVN+CDI ETC+G+SSQC PN
Sbjct: 467 SRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPN 526
Query: 527 IHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKD 586
+HK+DGY CD QG C+GGRCKTRDRQC+ +WG A+D++CYEKLN+EGTE+G+CG+
Sbjct: 527 LHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGH--AAADRFCYEKLNVEGTERGSCGRK 584
Query: 587 KDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV 646
W+QC+K+DVLCG+LLC NI PRLG+L G+I+S QG+ L+C GGHV+L +
Sbjct: 585 GSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGS 644
Query: 647 DLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHW 706
DL YVEDGT CGP M+CL+HRCLP ++FNFSTC S E ICS +GVCSNE KC+C W
Sbjct: 645 DLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDW 704
Query: 707 IGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ 766
G DC+ + P TG T G +GTNIIIG IAG +LV A++LG T WG+KN R
Sbjct: 705 TGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRG 764
Query: 767 R 767
R
Sbjct: 765 R 765
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 754 bits (1948), Expect = 0.0
Identities = 372/742 (50%), Positives = 489/742 (65%), Gaps = 44/742 (5%)
Query: 45 VERQSIVPLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDV 104
++++ +P RLIY + ES + LDT+ R + H+ QASFQ++AFG+ FILD+
Sbjct: 107 MQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDL 166
Query: 105 VLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDG 164
+LN+ LLSS+Y+E H E+G K KGGEHCYY G IRG DS VALSTC+GLHGMF D
Sbjct: 167 ILNNGLLSSDYVEIHYENG-KPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDD 225
Query: 165 NHTYLIEP-----EENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSK-----F 214
Y+IEP +E T + H + K+ ++S Q N+T + F
Sbjct: 226 TFVYMIEPLELVHDEKSTGRP----HIIQKTLAGQYSK-------QMKNLTMERGDQWPF 274
Query: 215 ILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD 274
+ + + + +++ R + EE KY+ELMIVNDH +KKHR S HTN +AKSVVN+ D
Sbjct: 275 LSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVD 334
Query: 275 LIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQ 334
IYK+QL TR+VLVA+ETW ++ I+ NP+ L EF KYR+ IK+ +DAVHL S
Sbjct: 335 SIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR-IKQHADAVHLISRVT 393
Query: 335 FESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKC 394
F RS +Y GG+CS +G GVNE+G +A L+QSLA N+GI + +C C
Sbjct: 394 FHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSS-RKPKCDC 452
Query: 395 EDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIET 454
++W GCIM +TG +KF++C+I EY DFL GGGACLFN+P+KL +P ECGNG++E
Sbjct: 453 TESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEA 512
Query: 455 GEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKK--CKFQPMGTVCREAVNDCDI 512
GEECDCG EC CCKKC+L+ + CSDG CC C FQP G CR+AVN+CDI
Sbjct: 513 GEECDCGFHVECY---GLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDI 569
Query: 513 RETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEK 572
E C+G+S QC PN+HK DGY+C+ QG C+ G CKTRD QC+YIWG K SDK+CYEK
Sbjct: 570 TEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEK 629
Query: 573 LNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT 632
LN EGTEKGNCGKD D WIQC+K DV CG+LLCTN+ PR+G+L GEI T QGR
Sbjct: 630 LNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRV 689
Query: 633 LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNG 692
++CSG HV L++D D+GYVEDGTPCGP MMCL+ +CL + + N S+C +G +CSG+G
Sbjct: 690 IDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHG 749
Query: 693 VCSNELKCVCNRHWIGSDC-------NTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGT 745
VCSNE C+C+ W G+DC N + P ++ K G + TN+IIG IAG
Sbjct: 750 VCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPK--------GPSATNLIIGSIAGA 801
Query: 746 ILVLALILGITAWGYKNYREQR 767
ILV A++LG T WG+KN +++R
Sbjct: 802 ILVAAIVLGGTGWGFKNVKKRR 823
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 372 bits (954), Expect = e-102
Identities = 225/706 (31%), Positives = 341/706 (48%), Gaps = 56/706 (7%)
Query: 85 HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139
H + + ++ I+++ N L++S + E H G V + HCYY G
Sbjct: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
Query: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199
H+RG DS V+LSTC GL G+ N +Y++EP ++ T + + ++ ++ +
Sbjct: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
Query: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
S N+ P S+ RR+ R + TKY+EL+IV D+ F++ +
Sbjct: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
Query: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
+ N D Y+ L RIVLV +E W +K ++S++P +L EF+ +R+
Sbjct: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
Query: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371
+ ++ D L SG F+ + G A I +C+ + GG+ N G AVTLA
Sbjct: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
Query: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430
L HN G+ D C+ GCIM TGY P F+ C+ ++ L G
Sbjct: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
Query: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486
G CLFN P + +CGN F+E GEECDCG P EC+ CC CTL D+ C+
Sbjct: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
Query: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
GLCC+ C+ +P GT CR++ N CD+ E C+G S C N++ DG+SC V G C+ G
Sbjct: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
Query: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605
C+T ++QC +WG + C+E++N G GNCGK K ++ +C RD CG + C
Sbjct: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
Query: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
+ P +G I + + +QQG + C G HV L +D+ D G V GT C +CL
Sbjct: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
Query: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY-FPHNDDAKT 723
+C ++ F C C G GVC+N C C HW C+ + F + D+
Sbjct: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
Query: 724 GITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQL 769
G+ TI +L IL + A G+ Y +++ L
Sbjct: 701 IRQADNQGL------------TIGILVTILCLLAAGFVVYLKRKTL 734
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 370 bits (951), Expect = e-102
Identities = 213/650 (32%), Positives = 320/650 (49%), Gaps = 43/650 (6%)
Query: 85 HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139
H + + ++ I+++ N L++S + E H G V + HCYY G
Sbjct: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
Query: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199
H+RG DS V+LSTC GL G+ N +Y++EP ++ T + + ++ ++ +
Sbjct: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
Query: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
S N+ P S+ RR+ R + TKY+EL+IV D+ F++ +
Sbjct: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
Query: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
+ N D Y+ L RIVLV +E W +K ++S++P +L EF+ +R+
Sbjct: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
Query: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371
+ ++ D L SG F+ + G A I +C+ + GG+ N G AVTLA
Sbjct: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
Query: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430
L HN G+ D C+ GCIM TGY P F+ C+ ++ L G
Sbjct: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
Query: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486
G CLFN P + +CGN F+E GEECDCG P EC+ CC CTL D+ C+
Sbjct: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
Query: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
GLCC+ C+ +P GT CR++ N CD+ E C+G S C N++ DG+SC V G C+ G
Sbjct: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
Query: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605
C+T ++QC +WG + C+E++N G GNCGK K ++ +C RD CG + C
Sbjct: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
Query: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
+ P +G I + + +QQG + C G HV L +D+ D G V GT C +CL
Sbjct: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
Query: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY 714
+C ++ F C C G GVC+N C C HW C+ +
Sbjct: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKF 690
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 368 bits (945), Expect = e-101
Identities = 238/706 (33%), Positives = 331/706 (46%), Gaps = 53/706 (7%)
Query: 85 HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGG--KTVEVKGGEHCYYQGHIR 142
H +A +V A G ILD+ N L + Y E H G +T K +HC+Y G +R
Sbjct: 61 HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120
Query: 143 GNPDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201
S V LSTC G+ G+ N +Y+IEP + Q H +Y+S L P
Sbjct: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQ-----HLIYRSE----HLKPPP 171
Query: 202 SE--FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
F+ T + L+ +++K++ RR R KY+EL +V D+L F+K+R
Sbjct: 172 GNCGFEHSKPTTRDWALQ-FTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQ 230
Query: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
T + N D Y+ L RI LV +E W N +SENP TL F+ +RR
Sbjct: 231 DATKHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKL 289
Query: 320 IKEK-SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAH 376
+ +K D L +G F + G A + +CS+ + GGVN + + V T+A + H
Sbjct: 290 LAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGH 349
Query: 377 NIGIISDKRKLASGECKCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLF 435
N G+ D C GCIM TG+ PK F CN E +L SGGG CL
Sbjct: 350 NFGMTHDSADC----CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLS 405
Query: 436 NKPSK--LLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQCSDGLCC 491
N P L CGNG++E GEECDCG EC CC CTL ++C+ G CC
Sbjct: 406 NMPDTRMLYGGRRCGNGYLEDGEECDCGEEEEC---NNPCCNASNCTLRPGAECAHGSCC 462
Query: 492 KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRD 551
+CK GT+CRE CD+ E C+G S C N ++MDG C+G Q C+ G C T
Sbjct: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522
Query: 552 RQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGN 610
QC+ +WG + C+EK+N+ G GNCGKD + +CN RD CG + C +
Sbjct: 523 EQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEA 582
Query: 611 IPRLGELDGEITSTLVVQQGRTLNCSGGHVKL--EEDVDL---GYVEDGTPCGPQMMCLE 665
P E + T ++ GR + C G HV EE+ D+ G V GT CG +C E
Sbjct: 583 RPL--ESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFE 640
Query: 666 HRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGI 725
+C + F C G C+G+GVC+N C C W CNT H +G
Sbjct: 641 GQCRNTSFFETEGC-----GKKCNGHGVCNNNQNCHCLPGWAPPFCNTP-GHGGSIDSGP 694
Query: 726 TLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQ 771
+ +G + +LV L+L + Y R+ +L Q
Sbjct: 695 MPPES--------VGPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQ 732
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 328 bits (842), Expect = 1e-89
Identities = 209/649 (32%), Positives = 319/649 (49%), Gaps = 61/649 (9%)
Query: 88 QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
Q S+ + A G I+ + N DLL +++ G + HC+Y+G++ G
Sbjct: 65 QVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVH 124
Query: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHF-HSVYKSRLFEFSLDDLPSEF 204
+S +ALS C GL G+ + N +Y IEP +N + HF H +Y+ +DD+ E
Sbjct: 125 NSSIALSDCFGLRGLLHLENASYGIEPLQNSS-----HFEHIIYR-------MDDVYKEP 172
Query: 205 QQVNITPSKFILKPRPKR------SKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLS 258
+ ++ +K I K K S QL R R V +T+Y+EL IV D K R
Sbjct: 173 LKCGVS-NKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVD-----KERYD 226
Query: 259 VVHTNTYAKS-----VVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFM 313
++ N A + N D +Y L RIVLV +E W N I L F+
Sbjct: 227 MMGRNQTAVREEMILLANYLDSMYI-MLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFV 285
Query: 314 KYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGK--TDLMAVT 369
++R F+ + + D+ L F + +G A++G +CS GG+N FG+ + A
Sbjct: 286 QWREKFLITRRRHDSAQLVLKKGFGGT-AGMAFVGTVCSRSHAGGINVFGQITVETFASI 344
Query: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSG 429
+A L HN+G+ D + +C C CIM ++G + F+ C+ E++ +
Sbjct: 345 VAHELGHNLGMNHDDGR----DCSCGA--KSCIM-NSGASGSRNFSSCSAEDFEKLTLNK 397
Query: 430 GGACLFN--KPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQC 485
GG CL N KP + P CGN ++ GEECDCGTP EC L+ CC+ C L ++C
Sbjct: 398 GGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELD--PCCEGSTCKLKSFAEC 455
Query: 486 SDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGG 545
+ G CCK C+F P GT+CR ++CD+ E C+G+S C P++ +GY C + C+ G
Sbjct: 456 AYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNG 515
Query: 546 RCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLC 605
C+ D QC+ I+G K A+ K C+ ++N +G GNCG + + +C + LCG L C
Sbjct: 516 MCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQC 575
Query: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
N+ IP G I ++ R C G +L DV D G V +GT CG +C
Sbjct: 576 ENVQEIPVFG-----IVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICR 630
Query: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNT 713
+C+ + N+ + K C G+GVC++ C C W +C T
Sbjct: 631 NFQCVDASVLNYDCDVQKK----CHGHGVCNSNKNCHCENGWAPPNCET 675
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 327 bits (839), Expect = 2e-89
Identities = 204/643 (31%), Positives = 308/643 (47%), Gaps = 42/643 (6%)
Query: 87 DQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGN 144
D ++A G +L++ NH LL+ YIE H G+ V + +HC+YQG +RG
Sbjct: 64 DMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGF 123
Query: 145 PDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSE 203
PDS+V L TC G+ G+ N +Y + P +DF H +++ +
Sbjct: 124 PDSWVVLCTCSGMSGLITLSRNASYYLRPWP-PRGSKDFSTHEIFRMEQL-LTWKGTCGH 181
Query: 204 FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTN 263
N + R +R+ RR KY+EL IV DH +F ++ HT
Sbjct: 182 RDPGNKAGMTSLPGGPQSRGRREARR-------TRKYLELYIVADHTLFLTRHRNLNHTK 234
Query: 264 TYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK 323
V N D + + L ++ L +E W ++ ++++ TL F+++RR ++
Sbjct: 235 QRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQR 293
Query: 324 S-DAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL---MAVTLAQSLAHNIG 379
D+ L +G F+ + G A + G+C GGV+ ++L A T+A + H++G
Sbjct: 294 PHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVST-DHSELPIGAAATMAHEIGHSLG 352
Query: 380 IISDKRKLASGEC-KCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 437
+ D G C + GC+M TG+ P+ F+ C+ + F GGGACL N
Sbjct: 353 LSHDP----DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNA 408
Query: 438 PSKLLDPPE--CGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGLCCKK 493
P L P CGNGF+E GEECDCG EC CC C+L +QC+ G CC +
Sbjct: 409 PDPGLPVPPALCGNGFVEAGEECDCGPGQEC---RDLCCFAHNCSLRPGAQCAHGDCCVR 465
Query: 494 CKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQ 553
C +P G +CR+A+ DCD+ E C+G SS C P+++ +DG C G C+ G C T ++Q
Sbjct: 466 CLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQ 525
Query: 554 CKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGNIP 612
C+ +WG + + C++ +N G GNCG+D + ++ C RD LCG L C G P
Sbjct: 526 CQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ--GGKP 583
Query: 613 RLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVD---LGYVEDGTPCGPQMMCLEHRCL 669
L + V G+ + C G +D LG VE GT CGP+M+C RC
Sbjct: 584 SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCR 643
Query: 670 PVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN 712
A CL T C +GVC++ C C W C+
Sbjct: 644 KNAFQELQRCL-----TACHSHGVCNSNHNCHCAPGWAPPFCD 681
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 311 bits (798), Expect = 1e-84
Identities = 207/704 (29%), Positives = 322/704 (45%), Gaps = 79/704 (11%)
Query: 88 QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
+ +++ G +L + N +LL+ Y E + GK + + CYYQGHI
Sbjct: 56 ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115
Query: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200
S ++STC GL G F G+ Y IEP D H+++K E + D
Sbjct: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173
Query: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257
+ QQ P+ ++K + R V+E KYIE +V D+ FK++
Sbjct: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222
Query: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317
+ + N +++YK +L T + LV ME W +K I+ N TL F K+R
Sbjct: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281
Query: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374
+ +++ D L + ++ + G A++ +CS G V + L +A T+A +
Sbjct: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341
Query: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433
HN G+ D CKC T C+M +Y+P F+ C+ Y F C
Sbjct: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394
Query: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489
LFN P + ++ P CGN +E GE+CDCGT EC CC K C + QC+ G
Sbjct: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451
Query: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549
CC+KC+F+ G VCR A ++CD+ E C+G S C + +++G+ C +G C G C T
Sbjct: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511
Query: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCT-NI 608
QC +WG +DK CY + N G++ G C + DT I C D +CG L C
Sbjct: 512 LQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGS 570
Query: 609 GNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRC 668
N+P G + +T + + ++G V +GT CG +C+ C
Sbjct: 571 DNLPWKGRIVTFLTCKTFDPE-------------DTSQEIGMVANGTKCGDNKVCINAEC 617
Query: 669 LPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
+ + ST SSK C G+ VC +EL+C C WI DC DD+
Sbjct: 618 VDIEKAYKSTNCSSK----CKGHAVCDHELQCQCEEGWIPPDC-------DDSSV----- 661
Query: 729 GNGVAGTNIIIGII---AGTILVLALILGITAWGYKNYREQRQL 769
V +I++G++ A +V+A+++ + K ++QR L
Sbjct: 662 ---VFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQRPL 702
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 307 bits (787), Expect = 2e-83
Identities = 192/600 (32%), Positives = 292/600 (48%), Gaps = 38/600 (6%)
Query: 87 DQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGN 144
D ++A G +L++ NH LL+ YIE H G+ V + +HC+YQG +RG
Sbjct: 64 DMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGF 123
Query: 145 PDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSE 203
PDS+V L TC G+ G+ N +Y + P +DF H +++ +
Sbjct: 124 PDSWVVLCTCSGMSGLITLSRNASYYLRPWP-PRGSKDFSTHEIFRMEQL-LTWKGTCGH 181
Query: 204 FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTN 263
N + R +R+ RR KY+EL IV DH +F ++ HT
Sbjct: 182 RDPGNKAGMTSLPGGPQSRGRREARR-------TRKYLELYIVADHTLFLTRHRNLNHTK 234
Query: 264 TYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK 323
V N D + + L ++ L +E W ++ ++++ TL F+++RR ++
Sbjct: 235 QRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQR 293
Query: 324 S-DAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL---MAVTLAQSLAHNIG 379
D+ L +G F+ + G A + G+C GGV+ ++L A T+A + H++G
Sbjct: 294 PHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVST-DHSELPIGAAATMAHEIGHSLG 352
Query: 380 IISDKRKLASGEC-KCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 437
+ D G C + GC+M TG+ P+ F+ C+ + F GGGACL N
Sbjct: 353 LSHDP----DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNA 408
Query: 438 PSKLLDPPE--CGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGLCCKK 493
P L P CGNGF+E GEECDCG EC CC C+L +QC+ G CC +
Sbjct: 409 PDPGLPVPPALCGNGFVEAGEECDCGPGQEC---RDLCCFAHNCSLRPGAQCAHGDCCVR 465
Query: 494 CKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQ 553
C +P G +CR+A+ DCD+ E C+G SS C P+++ +DG C G C+ G C T ++Q
Sbjct: 466 CLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQ 525
Query: 554 CKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGNIP 612
C+ +WG + + C++ +N G GNCG+D + ++ C RD LCG L C G P
Sbjct: 526 CQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ--GGKP 583
Query: 613 RLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVD---LGYVEDGTPCGPQMMC-LEHRC 668
L + V G+ + C G +D LG VE GT CGP+M+C H C
Sbjct: 584 SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNC 643
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 286 bits (732), Expect = 6e-77
Identities = 203/712 (28%), Positives = 321/712 (45%), Gaps = 87/712 (12%)
Query: 73 RVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTV--EVK 130
RVR L H ++ S+ + A G +F L + N DLL S Y E + G V + +
Sbjct: 41 RVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPR 100
Query: 131 GGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKS 190
G +HC+YQGH+ G PDS +LSTC GL G F G+ +LIEP + + H+VY++
Sbjct: 101 GQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG---EGGRHAVYQA 157
Query: 191 R--LFEFSLDDLPSEFQQVNITP-SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVN 247
L + + + P + + +PRP S ET+Y+EL +V
Sbjct: 158 EHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS---------RETRYVELYVVV 208
Query: 248 DHLMFKK--HRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENP 305
D+ F+ +V H VVN D +Y+ +L R+VLV +E W + ++F +S +P
Sbjct: 209 DNAEFQMLGSEAAVRHR---VLEVVNHVDKLYQ-KLNFRVVLVGLEIWNSQDRFHVSPDP 264
Query: 306 LITLREFMKY--RRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT 363
+TL + + R+ + D V L +G F + G A + +CS G + K
Sbjct: 265 SVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKN 324
Query: 364 DL-MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSG--CIM-GDTGYYLPKKFTQCNI 419
+ +A T+A + HN+G+ D+ C+C++ + CIM G G P+ F+ C+
Sbjct: 325 PVGVACTMAHEMGHNLGMDHDENVQG---CRCQERFEAGRCIMAGSIGSSFPRMFSDCSQ 381
Query: 420 EEYHDFLNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK- 476
FL CL N P S L+ P CGN F+E GE+CDCG P +C CC
Sbjct: 382 AYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDC---RNRCCNST 438
Query: 477 -CTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSC 535
C L + +QC+ G CC++CK +P G +CR + CD+ E C G +C + + +G C
Sbjct: 439 TCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPC 498
Query: 536 DGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNK 595
G G C+ G C T +QC+ WG A+++ C+ + G + D +QC
Sbjct: 499 SG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKG 556
Query: 596 RDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655
G +C ++ L + G V +GT
Sbjct: 557 GQQPLGRAICIV------------DVCHALTTEDGTAYEP---------------VPEGT 589
Query: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715
CGP+ +C + RC + + S C + C +GVC+++ +C C+ W C
Sbjct: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCAKLL 644
Query: 716 PHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQR 767
A SG+ + + +LVL ++ +T G YR+ R
Sbjct: 645 TEVHAA------SGS--------LPVFVVVVLVLLAVVLVTLAGIIVYRKAR 682
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 281 bits (720), Expect = 1e-75
Identities = 183/589 (31%), Positives = 280/589 (47%), Gaps = 42/589 (7%)
Query: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
+ CYY G++ G P+S VALSTC G GM + Y I+P T E H VYK
Sbjct: 157 DDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFE----HLVYK-- 210
Query: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEET--KYIELMIVNDH 249
DD + +T K + + S + V T +++EL++V D+
Sbjct: 211 ---IDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDN 267
Query: 250 LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITL 309
+ + + + +VVN+ D Y L+ ++L ++ W N S + L
Sbjct: 268 IRYLFSQSNATTVQHEVFNVVNIVDSFYHP-LEVDVILTGIDIWTASNPLPTSGDLDNVL 326
Query: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLM- 366
+F ++ + + D HLF + + G AY+ GIC GV+ F L+
Sbjct: 327 EDFSIWKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVV 385
Query: 367 -AVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDF 425
A+TL L HN+G+ D + C CE W CIM + KF+ C+ +Y D
Sbjct: 386 FAITLGHELGHNLGMQHDTQW-----CVCELQW--CIM-HAYRKVTTKFSNCSYAQYWDS 437
Query: 426 LNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDS 483
S G C+ P + CGN +E GEECDCGT +C + C CTL +
Sbjct: 438 TISSG-LCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPC-CLLNCTLHPGA 495
Query: 484 QCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICF 543
C+ G+CCK CKF P GT+CR+ V +CD+ E C+G S QC +++ DG SC+ V C+
Sbjct: 496 ACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCN-VNAFCY 554
Query: 544 GGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYL 603
C D QCK I+GQ ++ + CY+++N +G G+CG T+++C D++CG +
Sbjct: 555 EKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRV 614
Query: 604 LCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMM 662
C N+G IP L E ST+ C G L + D+G V+DGT CGP+ +
Sbjct: 615 QCENVGVIPNLIE-----HSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKI 669
Query: 663 CLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
C+ +C + + + + C+ G+C+N+ C CN W C
Sbjct: 670 CIRKKCASMVHLS-----QACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 277 bits (709), Expect = 3e-74
Identities = 183/593 (30%), Positives = 294/593 (49%), Gaps = 51/593 (8%)
Query: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
+ CYY G++ G P+S V S C G G+ TY IEP + T E H VYK
Sbjct: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFE----HLVYKVN 162
Query: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEE---ETKYIELMIVND 248
E + + + + + + P++ + ++EL++V +
Sbjct: 163 SNETQFPAMRCGLTEKEVARQQLEFEEAENSALE-----PKSAGDWWTHAWFLELVVVVN 217
Query: 249 H--LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPL 306
H ++ + +S V + + VVN+ D +Y+ QL T I+L+ +E W N F ++
Sbjct: 218 HDFFIYSQSNISKVQEDVFL--VVNIVDSMYQ-QLGTYIILIGIEIWNQGNVFPMTSIEQ 274
Query: 307 ITLREFMKYRRDFIKE-KSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF-GKT- 363
+ L +F ++++ + + + DA H+F + S G AY+ GIC GV+ F G T
Sbjct: 275 V-LNDFSQWKQISLSQLQHDAAHMFIKNSLISIL-GLAYVAGICRPPIDCGVDNFQGDTW 332
Query: 364 DLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYH 423
L A T+A L H +G+ D+ GE GCIM +T +KFT C+ Y
Sbjct: 333 SLFANTVAHELGHTLGMQHDEEFCFCGE-------RGCIM-NTFRVPAEKFTNCS---YA 381
Query: 424 DFLNS--GGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTL 479
DF+ + G+CL N P ++ CGNG +E E+CDCG+ +C + A C CTL
Sbjct: 382 DFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCE-QDACCLLNCTL 440
Query: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539
+ C+ GLCCK CKF P G +CR+ VN+CD+ E C+G S QC + + DG C
Sbjct: 441 RPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSD-S 499
Query: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599
C+ RC D+ C+ I+G+ ++ + CY+++N +G G+CG + T+++C+ DV
Sbjct: 500 AYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVF 559
Query: 600 CGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCG 658
CG + C N+ +IP L + TL + C G L ++ D+G V+DGT CG
Sbjct: 560 CGRVQCENVRDIPLLQD-----HFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCG 614
Query: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
P +C+ +C+ ++ + CL C+ G+C+N+ C C W C
Sbjct: 615 PGKICIHKKCVSLSVLS-HVCLPE----TCNMKGICNNKHHCHCGYGWSPPYC 662
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 267 bits (683), Expect = 3e-71
Identities = 182/633 (28%), Positives = 294/633 (46%), Gaps = 49/633 (7%)
Query: 84 THVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGK--TVEVKGGEHCYYQGHI 141
T+ ++ +++ + +L ++ + + L S Y E G+ T + +HC+YQG I
Sbjct: 54 TYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSI 113
Query: 142 RGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201
DS ++STC+GL G F + YLIEP + E H V+K L +P
Sbjct: 114 VHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGE----HLVFKYNL------RVP 163
Query: 202 SEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVH 261
+ T F K P ++ + + + +E KY+EL IV D +++++
Sbjct: 164 YG-ANYSCTELNFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNK 221
Query: 262 TNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIK 321
+VN ++IYK L + LV +E W ++K + N TL F ++ +K
Sbjct: 222 LRNRIWGMVNFVNMIYKT-LNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILK 280
Query: 322 EKSDAVH--LFSGSQFESSRSGAAYIGGIC------SLLKGGGVNEFGKTDLMAVTLAQS 373
+ D H L SG S G +Y GG+C S++K + T+++A +A
Sbjct: 281 TRKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIK----DLLPDTNIIANRMAHQ 336
Query: 374 LAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGAC 433
L HN+G+ D E C C+M G KF++C+ +YH +L C
Sbjct: 337 LGHNLGMQHD-------EFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTC 389
Query: 434 LFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCSDGL 489
+ N P D CGN ++ GEECDCG EC CC C L C++G
Sbjct: 390 MLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECT---NPCCDAHTCVLKPGFTCAEGE 446
Query: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549
CC+ C+ + G++CR A ++CD E C+G+S C + +++G+ C +G CF G+C T
Sbjct: 447 CCESCQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPT 506
Query: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIG 609
R+ QC ++ + S CY K+N +G + G C ++ ++ C ++DV CG + CT
Sbjct: 507 REDQCSELFDDEAIESHDICY-KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGE 565
Query: 610 NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCL 669
LGE + Q+ T+ C + + D+G V GT CG M+C CL
Sbjct: 566 LSSLLGE--DKTYHLKDPQKNATVKCKTIFL-YHDSTDIGLVASGTKCGEGMVCNNGECL 622
Query: 670 PVASFNFSTCLSSKEGTICSGNGVCSNELKCVC 702
+ ST S+ C+ N V + L+C C
Sbjct: 623 NMEKVYISTNCPSQ----CNENPVDGHGLQCHC 651
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 258 bits (660), Expect = 1e-68
Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)
Query: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
+CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK
Sbjct: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
Query: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
E + S F Q IT + + + ++++ Y+ E+
Sbjct: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
Query: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
++V D+ ++ ++ + +VN+ D I D + +++L +E W N + +
Sbjct: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
Query: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
+ ++ + K++ + I + + D HLF+ SG G+C+ + + F
Sbjct: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
Query: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+
Sbjct: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
Query: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
++ ++ L +K + + CGNG +E GEECDCG C + C CT
Sbjct: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
Query: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C
Sbjct: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
Query: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
+G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV
Sbjct: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
Query: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
CG + C N+ IP + + +T+ + + C L + D+G V+DGT C
Sbjct: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
Query: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
G +C+ C+ + N S+ C+ G+C+N+ C CN W +C
Sbjct: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 258 bits (660), Expect = 1e-68
Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)
Query: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
+CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK
Sbjct: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
Query: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
E + S F Q IT + + + ++++ Y+ E+
Sbjct: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
Query: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
++V D+ ++ ++ + +VN+ D I D + +++L +E W N + +
Sbjct: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
Query: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
+ ++ + K++ + I + + D HLF+ SG G+C+ + + F
Sbjct: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
Query: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+
Sbjct: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
Query: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
++ ++ L +K + + CGNG +E GEECDCG C + C CT
Sbjct: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
Query: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C
Sbjct: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
Query: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
+G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV
Sbjct: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
Query: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
CG + C N+ IP + + +T+ + + C L + D+G V+DGT C
Sbjct: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
Query: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
G +C+ C+ + N S+ C+ G+C+N+ C CN W +C
Sbjct: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 258 bits (660), Expect = 1e-68
Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)
Query: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
+CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK
Sbjct: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
Query: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
E + S F Q IT + + + ++++ Y+ E+
Sbjct: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
Query: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
++V D+ ++ ++ + +VN+ D I D + +++L +E W N + +
Sbjct: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
Query: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
+ ++ + K++ + I + + D HLF+ SG G+C+ + + F
Sbjct: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
Query: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+
Sbjct: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
Query: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
++ ++ L +K + + CGNG +E GEECDCG C + C CT
Sbjct: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
Query: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C
Sbjct: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
Query: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
+G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV
Sbjct: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
Query: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
CG + C N+ IP + + +T+ + + C L + D+G V+DGT C
Sbjct: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
Query: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
G +C+ C+ + N S+ C+ G+C+N+ C CN W +C
Sbjct: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 258 bits (660), Expect = 1e-68
Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)
Query: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
+CYY G++ G+P+S V+LSTC G G+ + Y I+P TT E H VYK
Sbjct: 99 NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154
Query: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
E + S F Q IT + + + ++++ Y+ E+
Sbjct: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202
Query: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
++V D+ ++ ++ + +VN+ D I D + +++L +E W N + +
Sbjct: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260
Query: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
+ ++ + K++ + I + + D HLF+ SG G+C+ + + F
Sbjct: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319
Query: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
L ++ +A L HN+G+ D+ C+C CIM + G KF+ C+
Sbjct: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371
Query: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
++ ++ L +K + + CGNG +E GEECDCG C + C CT
Sbjct: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430
Query: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
LT S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C + + DG C
Sbjct: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489
Query: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
+G C+ C R+ QC+ I+G + + CY++LN G G+CG T+I+CN DV
Sbjct: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549
Query: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
CG + C N+ IP + + +T+ + + C L + D+G V+DGT C
Sbjct: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604
Query: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
G +C+ C+ + N S+ C+ G+C+N+ C CN W +C
Sbjct: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 253 bits (646), Expect = 5e-67
Identities = 169/597 (28%), Positives = 270/597 (45%), Gaps = 62/597 (10%)
Query: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194
C+YQG+I G P S V +STC GL G+ N +Y IEP E+ E H +Y
Sbjct: 92 CHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFE----HVIY------ 141
Query: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEE---TKYIELMIVNDHLM 251
QV + L R L ++VE + KYIE+ ++ + +
Sbjct: 142 -----------QVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQL 190
Query: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311
+ ++ + + I+ I+L ++E W +NK A + L
Sbjct: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHT 249
Query: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368
F++++ ++ + V + +S+ GA + G +C GGV +T + +AV
Sbjct: 250 FLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAV 309
Query: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426
LAQ L+ ++GI D KC+ + + CIM + K F+ C+ E++ F+
Sbjct: 310 ILAQLLSLSMGITYDDIN------KCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFI 363
Query: 427 NSGGGACLFNKPSKLLDP-----PECGNGFIETGEECDCGTPAECVLEGAECCK--KCTL 479
+ CL N+P LDP CGN +E GEECDCGT +C L G CC C
Sbjct: 364 SKQKSQCLHNQPR--LDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRF 421
Query: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539
S C++G CC+ C F +CR + +CD+ E C+G+S+ C N + G+ C Q
Sbjct: 422 KAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481
Query: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599
IC G C + D+QC +G++V CY LN + GNCG + QC ++
Sbjct: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQ 541
Query: 600 CGYLLCTNIG----NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655
CG L+C +G IPR + I+ L + + + H D +++DGT
Sbjct: 542 CGKLICKYVGKFLLQIPRATIIYANISGHLCI----AVEFASDHA----DSQKMWIKDGT 593
Query: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN 712
CG +C RC+ + + C + K C+ GVC+N+ C C+ ++ DC+
Sbjct: 594 SCGSNKVCRNQRCVSSSYLGYD-CTTDK----CNDRGVCNNKKHCHCSASYLPPDCS 645
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 251 bits (641), Expect = 2e-66
Identities = 197/713 (27%), Positives = 329/713 (46%), Gaps = 67/713 (9%)
Query: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194
CYYQG+I G PDS V LSTC GL G+ N +Y IEP E+ + H +YK
Sbjct: 95 CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQ----HVLYK----- 145
Query: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQL--RRYPRNVEEETKYIELMIVNDHLMF 252
L +E + I + LK +P + + P + Y+E+ IV D ++
Sbjct: 146 -----LKNEDNDIAIFIDRS-LKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLY 199
Query: 253 KKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREF 312
+ +V +A+ ++ Q K IVL ++E W+ +NK + L++F
Sbjct: 200 DYWGSDSMIVTNKVIEIVGLANSMFT-QFKVTIVLSSLELWSDENKISTVGEADELLQKF 258
Query: 313 MKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAVT 369
+++++ ++ + + GA + G +C GV + K + AV
Sbjct: 259 LEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFAVI 318
Query: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFLN 427
+ Q LA ++GI D K KC+ + S CIM K F+ C++ + +F++
Sbjct: 319 VTQMLALSLGISYDDPK------KCQCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFIS 372
Query: 428 SGGGACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDS 483
+ G CL NKP K P CGNG +E E CDCGT A+C A CC + C L +
Sbjct: 373 NVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQC--GPASCCDFRTCVLKDGA 430
Query: 484 QCSDGLCCKKCKFQPMGTVCR-EAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGIC 542
+C GLCCK C+ G CR +A +CDI E C+G+S +C P+I ++G SC + IC
Sbjct: 431 KCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFIC 490
Query: 543 FGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDT-WIQCNKRDVLCG 601
+ G C D +C+ ++G+ + CYE++ + GNCG+D++ ++ C R+++CG
Sbjct: 491 YDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICG 550
Query: 602 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQ 660
L+CT P + +G++ V R C KL V D V++G+ C
Sbjct: 551 RLVCTYPTRKP-FHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIG 605
Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN------TY 714
+C+ C+ S + S++ CSG+GVC + KC C+ + +C +
Sbjct: 606 RVCVNRECVESRIIKASAHVCSQQ---CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSI 662
Query: 715 FPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKN-YREQRQLPQGD 773
FP D SG T ++ +IA IL++ + + K + ++ + P +
Sbjct: 663 FPEEDMGSIMERASGK-TENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSE 721
Query: 774 YVKKPGDGDSF------------YSDIPPGVSTNSASSSKKRSNGLSHSWSER 814
K G ++ Y+ S++ A +SK +S + +++ R
Sbjct: 722 -SKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSR 773
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,821,112
Number of Sequences: 37866
Number of extensions: 1849155
Number of successful extensions: 4919
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 4083
Number of HSP's gapped (non-prelim): 618
length of query: 859
length of database: 18,247,518
effective HSP length: 111
effective length of query: 748
effective length of database: 14,044,392
effective search space: 10505205216
effective search space used: 10505205216
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.