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Search of human proteins with 46909598
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46909598 a disintegrin and metalloproteinase domain 15
isoform 5 preproprotein [Homo sapiens]
(862 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 1823 0.0
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 1818 0.0
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 1735 0.0
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 1713 0.0
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 1678 0.0
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 1560 0.0
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 543 e-154
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 516 e-146
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 516 e-146
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 508 e-144
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 479 e-135
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 426 e-119
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 399 e-111
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 392 e-109
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 313 3e-85
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot... 313 4e-85
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 313 6e-85
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 313 6e-85
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 313 6e-85
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 313 6e-85
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 313 6e-85
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s... 312 7e-85
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 295 1e-79
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 288 1e-77
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 286 6e-77
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 285 1e-76
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 273 4e-73
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 273 4e-73
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 273 4e-73
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 273 4e-73
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 1823 bits (4721), Expect = 0.0
Identities = 862/862 (100%), Positives = 862/862 (100%)
Query: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
Query: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK 780
LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK 780
Query: 781 RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG 840
RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG
Sbjct: 781 RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG 840
Query: 841 IPPLVVPSRPAPPPPTVSSLYL 862
IPPLVVPSRPAPPPPTVSSLYL
Sbjct: 841 IPPLVVPSRPAPPPPTVSSLYL 862
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 1818 bits (4709), Expect = 0.0
Identities = 862/863 (99%), Positives = 862/863 (99%), Gaps = 1/863 (0%)
Query: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
Query: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK-ASALSFPAPPSRPLPPDPVS 779
LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK ASALSFPAPPSRPLPPDPVS
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVS 780
Query: 780 KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA 839
KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA
Sbjct: 781 KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA 840
Query: 840 GIPPLVVPSRPAPPPPTVSSLYL 862
GIPPLVVPSRPAPPPPTVSSLYL
Sbjct: 841 GIPPLVVPSRPAPPPPTVSSLYL 863
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 1735 bits (4494), Expect = 0.0
Identities = 829/863 (96%), Positives = 833/863 (96%), Gaps = 25/863 (2%)
Query: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
Query: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK-ASALSFPAPPSRPLPPDPVS 779
LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK ASALSFPAPPSRPLPPDPVS
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDPVS 780
Query: 780 KRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGA 839
KRLQ++ +P PP +PLPA DPQGRCPSGDLPGPGA
Sbjct: 781 KRLQSQGPAKPPPPRKPLPA------------------------DPQGRCPSGDLPGPGA 816
Query: 840 GIPPLVVPSRPAPPPPTVSSLYL 862
GIPPLVVPSRPAPPPPTVSSLYL
Sbjct: 817 GIPPLVVPSRPAPPPPTVSSLYL 839
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 1713 bits (4436), Expect = 0.0
Identities = 816/862 (94%), Positives = 823/862 (95%), Gaps = 24/862 (2%)
Query: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
Query: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK 780
LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKA P PP+RPLP DPV +
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKAELADRPNPPTRPLPADPVVR 780
Query: 781 RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG 840
+++ +P PP +PLPA DPQGRCPSGDLPGPGAG
Sbjct: 781 SPKSQGPAKPPPPRKPLPA------------------------DPQGRCPSGDLPGPGAG 816
Query: 841 IPPLVVPSRPAPPPPTVSSLYL 862
IPPLVVPSRPAPPPPTVSSLYL
Sbjct: 817 IPPLVVPSRPAPPPPTVSSLYL 838
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 1678 bits (4345), Expect = 0.0
Identities = 805/862 (93%), Positives = 808/862 (93%), Gaps = 48/862 (5%)
Query: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
Query: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPVSK 780
LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK+ + P PP +
Sbjct: 721 LHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPPRK--------- 771
Query: 781 RLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAG 840
P LPADPQGRCPSGDLPGPGAG
Sbjct: 772 --------------------P-------------------LPADPQGRCPSGDLPGPGAG 792
Query: 841 IPPLVVPSRPAPPPPTVSSLYL 862
IPPLVVPSRPAPPPPTVSSLYL
Sbjct: 793 IPPLVVPSRPAPPPPTVSSLYL 814
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 1560 bits (4039), Expect = 0.0
Identities = 738/746 (98%), Positives = 740/746 (99%), Gaps = 1/746 (0%)
Query: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV
Sbjct: 1 MRLALLWALGLLGAGSPLPSWPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLPISLKKV 60
Query: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ
Sbjct: 61 LQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQ 120
Query: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA
Sbjct: 121 GRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCA 180
Query: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL
Sbjct: 181 LSWRESVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTL 240
Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS
Sbjct: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL
Sbjct: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM 420
Query: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC
Sbjct: 421 AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSK 660
Query: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR
Sbjct: 661 CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
Query: 721 LHQRLCQLKGPTCQYRAAQSGPSERP 746
LHQRLCQLKGPTCQY + + PS P
Sbjct: 721 LHQRLCQLKGPTCQY-SLRGQPSPHP 745
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 543 bits (1400), Expect = e-154
Identities = 332/874 (37%), Positives = 458/874 (52%), Gaps = 78/874 (8%)
Query: 42 EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
E + V DL I +K + PE L I+L+ + I+ L +N L+ T Y
Sbjct: 41 EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
Query: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
DGT V ++ +T L +C Y G VRGY+ S VS+ TCSGLRGL+V E SY LE
Sbjct: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
Query: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
+ + + G +C K PP +RH +R+ + TK
Sbjct: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
Query: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
VELVIVAD+ E Q+ +D + + R +E+A +D F+RPLN+R+ LVG+E W D +
Sbjct: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
Query: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
S +P +L FL WR+ LLPR HD+AQLV+G F G T+GMA S+C+ D SGG+ M
Sbjct: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
Query: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
DHS + LG A ++AHELGH+ G++HD C C CIM AST + + FS+C
Sbjct: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
Query: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
SR+ LE +L GMG CLF LP + CGN FVE GE+CDCG ++C++ CC++
Sbjct: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
Query: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
TC L+P A CA G CC++CQL+P+G CR + CDLPEFC G S CP +V L DG
Sbjct: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
Query: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
C C +G C ++ QQC +LWGPGA+PA +C + N+ G+ +G+CG+ S+ C
Sbjct: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
Query: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
RDA CG++QCQ G ++P++G+ + I + G + C H+ LG D+ P L L
Sbjct: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
Query: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC------ 684
GT C G +C++ +CQ + + G EC +CHG GVC++ ++C+CE WAPP C
Sbjct: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFG 693
Query: 685 ------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQRLCQLKGPT------ 732
+ LT G+L+++L LL + Y R L + L K T
Sbjct: 694 GSTDSGPIRQADNQGLTIGILVTILCLLAAGFV--VYLKRKTLIRLLFTNKKTTIEKLRC 751
Query: 733 ------------CQYRAAQSG-------PSERP--GPPQRALLARGTKAS----ALSFPA 767
CQ G P P P+R L + S L+ P
Sbjct: 752 VRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQ 811
Query: 768 PPS--RPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADP 825
P S R LPP + R P+ P RPLPA P +R ++QG KP PP+KPLPADP
Sbjct: 812 PQSTQRVLPPLHRAPR-------APSVPARPLPAKPALR--QAQGTCKPNPPQKPLPADP 862
Query: 826 QG---RCPSGDLPGPGAGIPPL-VVPSRPAPPPP 855
R PG L + P RPAP P
Sbjct: 863 LARTTRLTHALARTPGQWETGLRLAPLRPAPQYP 896
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 516 bits (1330), Expect = e-146
Identities = 321/810 (39%), Positives = 423/810 (52%), Gaps = 44/810 (5%)
Query: 21 WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
WP+P G + P +P+ P + D P +SL++ + S P+ + LE +G
Sbjct: 23 WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74
Query: 78 DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
+LEL +N L+ Y PDG VV + ++C YQGRVRG+ SWV +CTCS
Sbjct: 75 QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134
Query: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
G+ GL+ L+ SY L +G D I Q L G TC R+ +
Sbjct: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191
Query: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
P G + R RR+ K +EL IVADH+ ++R+ H R LEVA +D R
Sbjct: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250
Query: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
L+++VAL GLE WT+RD ++ + TL FL WRR L + PHDSAQL+TG +F G
Sbjct: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309
Query: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
TVG+A +C + SGGV+ DHS +G A+++AHE+GHSLGL HD G C A
Sbjct: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367
Query: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
+ C+M A+T FS CSRR L G G+CL P LP A CGN FVE
Sbjct: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427
Query: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
GE+CDCG +C D CC + C LRPGAQCA G CC C L+P+G CR GDCDLPE
Sbjct: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486
Query: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
FC G SS CPPDV L DG PCA G C G C + QQCQ LWGPG+ PA C Q N
Sbjct: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546
Query: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
+ G+A G+CG++ G ++ C RDA+CG+LQCQ G+ LL + T+ ++G E+
Sbjct: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605
Query: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
C L L S D+ L PGT CGP +VC RC++ Q C + CH HGVC+
Sbjct: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCN 664
Query: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
SN +C+C GWAPP C + ++A + T L + L VLL L+ W
Sbjct: 665 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 724
Query: 719 ARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPV 778
RL Q C+ A SGP + P R G L P +P P DP
Sbjct: 725 YRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELG-PTATGQPWPLDPE 780
Query: 779 SKRLQAELADRPNPPTRPLPADPVVRSPKS 808
+ + ++P P P P V+ P+S
Sbjct: 781 NSHEPSSHPEKPLPAVSPDPQADQVQMPRS 810
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 516 bits (1328), Expect = e-146
Identities = 313/880 (35%), Positives = 458/880 (52%), Gaps = 91/880 (10%)
Query: 27 GGTEEQQAESEKAPREPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQ 86
G T + S K E + PQ + P+ K L+ L ++ +G IL+L +
Sbjct: 29 GWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAEL------RVMAEGRELILDLEK 82
Query: 87 NRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCSGLRGLVVLT 146
N +L T Y G + ++C Y G VR S V++ TC G+RGL+ ++
Sbjct: 83 NEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVS 142
Query: 147 PERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRESV-------HTQKPPEHPLGQ 199
SY +E P D +G +I R + L P C + TQ+ + P
Sbjct: 143 SNLSYVIEPLP-DSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPR-- 199
Query: 200 RHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVALLLDTFFRPLNVRVA 258
R +R+ + K VEL +VAD+ E QK R D ++ +E+A +D F+R LN+R+A
Sbjct: 200 ---RMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIA 256
Query: 259 LVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAI 318
LVGLE WT ++ E+S NP TL +FL WRR LL + HD+AQL+TG SF G T+G+A
Sbjct: 257 LVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKYHDNAQLITGMSFHGTTIGLAP 315
Query: 319 QNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIM 378
++CS SGGVNMDHS + +GVA+++AHE+GH+ G+ HD ++ C A CIM
Sbjct: 316 LMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHD---SADCCSASAADGGCIM 372
Query: 379 EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCD 436
A+T F+ C+RR L++ L G G CL +P + CGN ++E GE+CD
Sbjct: 373 AAATGHPFPKVFNGCNRRELDRYLQSGGGMCL-SNMPDTRMLYGGRRCGNGYLEDGEECD 431
Query: 437 CGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGD 496
CG ++C +PCC++ C LRPGA+CA G CC C+L G CR CDLPEFC G
Sbjct: 432 CGEEEECNNPCCNASNCTLRPGAECAH-GSCCHQCKLLAPGTLCREQARQCDLPEFCTGK 490
Query: 497 SSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNA 556
S CP + DG PC GGQA C +G C +Y +QCQ LWGPGA+PA LC + N G+
Sbjct: 491 SPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDT 550
Query: 557 FGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELNCSWVH 616
FG+CG++ +G + C RDA CG++QCQ+ +PL + + TI +NG ++ C H
Sbjct: 551 FGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPID-TTIIMNGRQIQCRGTH 609
Query: 617 LDLG----SDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRH 672
+ G D+ P L + GT CG +C + +C+ + C KC+GHGVC++N++
Sbjct: 610 VYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQN 669
Query: 673 CYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGASYWYRAR 720
C+C GWAPP C T ++ + G+L+++LVL VL+++ +Y R
Sbjct: 670 CHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLM----YYCCR 725
Query: 721 LHQRLCQLKGP----------TCQYRAAQSGPSERPGPPQRALLARGTKASALSFPA--- 767
+ +L QLK +C +R +Q+ + P + +G K ++ P
Sbjct: 726 QNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQG-KRKVINTPEILR 784
Query: 768 ----PPSRP--------LPPDPVSKRLQAELADRPNPPT---------RPLPADPVVRSP 806
PP RP PP P+ L + P P + RP P+ P+ +P
Sbjct: 785 KPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPAP 844
Query: 807 K---SQGPAKPPPPRKPLPADP-QGRCPSGDLPGPGAGIP 842
SQ ++P PP+K LPA+P GR LP PG P
Sbjct: 845 NCIVSQDFSRPRPPQKALPANPVPGR---RSLPRPGGASP 881
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 508 bits (1309), Expect = e-144
Identities = 269/654 (41%), Positives = 378/654 (57%), Gaps = 18/654 (2%)
Query: 42 EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
E + V DL I +K + PE L I+L+ + I+ L +N L+ T Y
Sbjct: 41 EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
Query: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
DGT V ++ +T L +C Y G VRGY+ S VS+ TCSGLRGL+V E SY LE
Sbjct: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
Query: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
+ + + G +C K PP +RH +R+ + TK
Sbjct: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
Query: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
VELVIVAD+ E Q+ +D + + R +E+A +D F+RPLN+R+ LVG+E W D +
Sbjct: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
Query: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
S +P +L FL WR+ LLPR HD+AQLV+G F G T+GMA S+C+ D SGG+ M
Sbjct: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
Query: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
DHS + LG A ++AHELGH+ G++HD C C CIM AST + + FS+C
Sbjct: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
Query: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
SR+ LE +L GMG CLF LP + CGN FVE GE+CDCG ++C++ CC++
Sbjct: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
Query: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
TC L+P A CA G CC++CQL+P+G CR + CDLPEFC G S CP +V L DG
Sbjct: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
Query: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
C C +G C ++ QQC +LWGPGA+PA +C + N+ G+ +G+CG+ S+ C
Sbjct: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
Query: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
RDA CG++QCQ G ++P++G+ + I + G + C H+ LG D+ P L L
Sbjct: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
Query: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC 684
GT C G +C++ +CQ + + G EC +CHG GVC++ ++C+CE WAPP C
Sbjct: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFC 687
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 479 bits (1233), Expect = e-135
Identities = 311/810 (38%), Positives = 410/810 (50%), Gaps = 70/810 (8%)
Query: 21 WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
WP+P G + P +P+ P + D P +SL++ + S P+ + LE +G
Sbjct: 23 WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74
Query: 78 DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
+LEL +N L+ Y PDG VV + ++C YQGRVRG+ SWV +CTCS
Sbjct: 75 QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134
Query: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
G+ GL+ L+ SY L +G D I Q L G TC R+ +
Sbjct: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191
Query: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
P G + R RR+ K +EL IVADH+ ++R+ H R LEVA +D R
Sbjct: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250
Query: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
L+++VAL GLE WT+RD ++ + TL FL WRR L + PHDSAQL+TG +F G
Sbjct: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309
Query: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
TVG+A +C + SGGV+ DHS +G A+++AHE+GHSLGL HD G C A
Sbjct: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367
Query: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
+ C+M A+T FS CSRR L G G+CL P LP A CGN FVE
Sbjct: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427
Query: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
GE+CDCG +C D CC + C LRPGAQCA G CC C L+P+G CR GDCDLPE
Sbjct: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486
Query: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
FC G SS CPPDV L DG PCA G C G C + QQCQ LWGPG+ PA C Q N
Sbjct: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546
Query: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
+ G+A G+CG++ G ++ C RDA+CG+LQCQ G+ LL + T+ ++G E+
Sbjct: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605
Query: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
C L L S D+ L PGT CGP + VC+
Sbjct: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRM--------------------------VCN 638
Query: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
SN +C+C GWAPP C + ++A + T L + L VLL L+ W
Sbjct: 639 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 698
Query: 719 ARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPV 778
RL Q C+ A SGP + P R G L P +P P DP
Sbjct: 699 YRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELG-PTATGQPWPLDPE 754
Query: 779 SKRLQAELADRPNPPTRPLPADPVVRSPKS 808
+ + ++P P P P V+ P+S
Sbjct: 755 NSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 426 bits (1095), Expect = e-119
Identities = 270/810 (33%), Positives = 406/810 (50%), Gaps = 83/810 (10%)
Query: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
++ +G HI+ L +N++L+P + Y +GT + + +C Y+G V G S ++
Sbjct: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
Query: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE---SVHT 189
+ C GLRGL+ L SY +E II R+ D++ C +S ++
Sbjct: 130 LSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAK 188
Query: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDT 248
+ E P + +RRRR V+ +T+ VEL IV D R+ + + +A LD+
Sbjct: 189 DEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDS 248
Query: 249 FFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTS 308
+ LN+R+ LVGLE WT +L+ I L NF+ WR L+ R HDSAQLV
Sbjct: 249 MYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKG 308
Query: 309 FSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368
F G T GMA ++CS +GG+N+ ++ AS +AHELGH+LG++HD G C C
Sbjct: 309 FGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSCG 366
Query: 369 GPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFCGNM 427
AK+CIM + NFS+CS EK L+ G+CL P A CGN
Sbjct: 367 ----AKSCIMNSGAS--GSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
Query: 428 FVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD 486
V+ GE+CDCG +C +DPCC+ TC+L+ A+CA G CC++C+ P G CR +
Sbjct: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAY-GDCCKDCRFLPGGTLCRGKTSE 479
Query: 487 CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLC 546
CD+PE+C G S C PDV + +G PC +A C +G C Y QCQ ++G A+ A C
Sbjct: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
Query: 547 LQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVN 606
N++G+ FG+CG + Y C +A+CG+LQC+ + P+ G + ++
Sbjct: 540 FIEVNSKGDRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAII--QTPSR 596
Query: 607 GTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECRSKCHGHG 665
GT+ C V LGSDV P + GT CG G +C + +C +L + + KCHGHG
Sbjct: 597 GTK--CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654
Query: 666 VCDSNRHCYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGA 713
VC+SN++C+CE GWAPP+C T+ + ++L GLL+ +++ L++
Sbjct: 655 VCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAI 714
Query: 714 SYWYRARLHQRLCQLKGPTCQYRAA---QSGPSERPGPPQRALLARGTKASALSFPAPPS 770
+ + R K + Y + Q+ PS +PG R + P P
Sbjct: 715 FIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVS-----------PVTPP 763
Query: 771 RPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCP 830
R +P A+R PT + P+ Q P++PPPP+ + + QG
Sbjct: 764 REVPI----------YANRFAVPTY------AAKQPQ-QFPSRPPPPQPKVSS--QGN-- 802
Query: 831 SGDLPGPGAGIPPLVVPSRPAPPPPTVSSL 860
++P+RPAP PP SSL
Sbjct: 803 --------------LIPARPAPAPPLYSSL 818
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 399 bits (1025), Expect = e-111
Identities = 283/812 (34%), Positives = 390/812 (48%), Gaps = 89/812 (10%)
Query: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
PE + L G + L L +NR+L+ T + +G+ V + ++C YQG V G
Sbjct: 54 PERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEG 113
Query: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE 185
Y S S+ TC+GLRG + + G G + + + L TC +S +
Sbjct: 114 YPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVS-DD 172
Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALL 245
S+ + P R ET+ VEL +V D++E Q + +R LEV
Sbjct: 173 SLGSLLGPRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNH 232
Query: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
+D ++ LN RV LVGLE W +D +SP+P+VTLEN L W+ R HD+ QL+T
Sbjct: 233 VDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLIT 292
Query: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
G F+G TVG A +++CS SG VN DHS + +GVA ++AHE+GH+LG+DHD C
Sbjct: 293 GVDFTGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGC 351
Query: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAA--F 423
C A CIM S FS+CS+ LE L CL P L +
Sbjct: 352 RCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCL-ANAPDLSHLVGGPV 410
Query: 424 CGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPT 483
CGN+FVE GEQCDCG +DC + CC+S TCQL GAQCA G CCQ C+++P+G CRP
Sbjct: 411 CGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCA-HGTCCQECKVKPAGELCRPK 469
Query: 484 RGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAA 543
+ CDL EFC G +CP D +G PC+GG C +G C + AQQCQ+ WGPG Q A
Sbjct: 470 KDMCDLEEFCDGRHPECPEDAFQENGTPCSGG--YCYNGACPTLAQQCQAFWGPGGQAAE 527
Query: 544 PLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETI 603
C + C + Y R +CG LQC+ G+ QPL +I +
Sbjct: 528 ESCFSY-----DILPGC---KASRY-----RADMCGVLQCKGGQ-QPLGRAIC-----IV 568
Query: 604 DVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHG 663
DV C + + G+ +P+ GT CGP VC RCQ + + + C ++CH
Sbjct: 569 DV------CHALTTEDGT-AYEPV--PEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHN 619
Query: 664 HGVCDSNRHCYCEEGWAPPDCT---TQLKATSSLTTGLLLSLLVLLVLVML---GASYWY 717
HGVC+ + C+C GWAPP C T++ A S ++ +LVLL +V++ G +
Sbjct: 620 HGVCNHKQECHCHAGWAPPHCAKLLTEVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYR 679
Query: 718 RAR--------------------LHQRLCQL--KG--PTCQYRAAQSGPSERPGPPQRAL 753
+AR HQ ++ KG P + P+ PG P R
Sbjct: 680 KARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQPARH- 738
Query: 754 LARGTKASALSFPAPP---SRPLPPDPVSKRLQAELADRPN--PPTRPLPADPVVRSPKS 808
+ A PAPP S P P PV R + +P PP P+ +P
Sbjct: 739 -PASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAGAANP-- 795
Query: 809 QGPA----------KPPPPRK---PLPADPQG 827
GPA KPP RK LP P+G
Sbjct: 796 -GPAEGAVGPKVALKPPIQRKQGAELPQHPRG 826
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 392 bits (1007), Expect = e-109
Identities = 230/658 (34%), Positives = 338/658 (51%), Gaps = 31/658 (4%)
Query: 62 QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
Q L+ K+ ++G +L L +N+ L+ T +Y G + + +++C YQG
Sbjct: 50 QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
Query: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
+ S SI TC GLRG +R + P D Q + D TC
Sbjct: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
Query: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
+ H Q+ P + + R V K +E +V D+ E ++Y + Q +
Sbjct: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
Query: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
R E+A ++ ++ LN VALVG+E WT +D ++I+PN + TLENF WR + L R
Sbjct: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
Query: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
HD AQL+T T +G TVG+A +++CSP +S GV DHS ++L VA ++AHE+GH+ G+
Sbjct: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
Query: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
HD SC CP + C+M+ + F +FS+CSR + +K D + +CLF LP+
Sbjct: 349 HD--DYSCKCP----STICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
Query: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
CGN VE GE CDCG ++C + CCD+ TC+++ QCA G CC+ CQ + +
Sbjct: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
Query: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
G CRP + +CDLPE C G S CP D +G PC G+ C+ G C + +QC LWG
Sbjct: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
Query: 537 PGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIR 596
PG + A C N G+ +G C R + + C D +CG+L CQ G
Sbjct: 522 PGTEVADKSC-YNRNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQ--------GGSD 571
Query: 597 DLLWETIDVNGTELNCSWVHLDLGSDVAQPL-LTLPGTACGPGLVCIDHRCQRVD-LLGA 654
+L W+ V T L C + D +Q + + GT CG VCI+ C ++ +
Sbjct: 572 NLPWKGRIV--TFLTCKTFDPE---DTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKS 626
Query: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDC-TTQLKATSSLTTGLLLSLLVLLVLVML 711
C SKC GH VCD C CEEGW PPDC + + S+ G+L + V+ V+V +
Sbjct: 627 TNCSSKCKGHAVCDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAM 684
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 313 bits (803), Expect = 3e-85
Identities = 208/684 (30%), Positives = 327/684 (47%), Gaps = 33/684 (4%)
Query: 67 EPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGY 126
E L +++L+ + +L LL++RE + + +Y G +++C YQG +
Sbjct: 57 EELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHE 116
Query: 127 AGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
S SI TC+GLRG + +R Y +E +G ++ + +L +P + S E
Sbjct: 117 YDSAASISTCNGLRGFFRINDQR-YLIEPVKYSDEGEHLVFKY-NLRVP-YGANYSCTEL 173
Query: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALL 245
T+K + + + E K VEL IVAD + ++ L NR +
Sbjct: 174 NFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNF 232
Query: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
++ ++ LN+ V LVG+E WT D +E+ N TL F W+ L R D L++
Sbjct: 233 VNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS 292
Query: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
G G++ +C P +S + D +A+ +AH+LGH+LG+ HD
Sbjct: 293 GKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHD----EF 348
Query: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFC 424
PC P+ C+M+ S +P L FS CS+ + L D +C+ P FC
Sbjct: 349 PCT--CPSGKCVMD-SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
Query: 425 GNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTR 484
GN ++ GE+CDCG +C +PCCD+ TC L+PG CA +G CC++CQ++ +G CRP +
Sbjct: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCA-EGECCESCQIKKAGSICRPAK 464
Query: 485 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP 544
+CD PE C G S CP D +G PC + C G+C + QC L+ A +
Sbjct: 465 DECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHD 524
Query: 545 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID 604
+C + NT+GN FG C +N ++ C +D CG++ C G LLG + +
Sbjct: 525 ICYK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQ 582
Query: 605 VNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD-LLGAQECRSKCHG 663
N T + C + L D L GT CG G+VC + C ++ + + C S+C+
Sbjct: 583 KNAT-VKCKTIF--LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNE 639
Query: 664 HGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ 723
+ V C+CEEG AP C L T+ + L+V+LVLV++G ++
Sbjct: 640 NPVDGHGLQCHCEEGQAPVACEETLHVTN------ITILVVVLVLVIVGIGVLILLVRYR 693
Query: 724 RLCQLKGPTCQYRAAQSGPSERPG 747
+ +LK QS P+E G
Sbjct: 694 KCIKLK-------QVQSPPTETLG 710
>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
[Homo sapiens]
Length = 540
Score = 313 bits (802), Expect = 4e-85
Identities = 174/482 (36%), Positives = 257/482 (53%), Gaps = 13/482 (2%)
Query: 62 QTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQG 121
Q L+ K+ ++G +L L +N+ L+ T +Y G + + +++C YQG
Sbjct: 50 QEQFETELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQG 109
Query: 122 RVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGP--GDLQGPPIISRIQDLHLPGHTC 179
+ S SI TC GLRG +R + P D Q + D TC
Sbjct: 110 HILNEKVSDASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTC 169
Query: 180 ALSWRESVHT-QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-HLLN 237
+ H Q+ P + + R V K +E +V D+ E ++Y + Q +
Sbjct: 170 GMDGVLWAHDLQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRK 229
Query: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
R E+A ++ ++ LN VALVG+E WT +D ++I+PN + TLENF WR + L R
Sbjct: 230 RVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKR 289
Query: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
HD AQL+T T +G TVG+A +++CSP +S GV DHS ++L VA ++AHE+GH+ G+
Sbjct: 290 HDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGHNFGMF 348
Query: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPS 416
HD SC C P+ C+M+ + F +FS+CSR + +K D + +CLF LP+
Sbjct: 349 HD--DYSCKC----PSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPT 402
Query: 417 LPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPS 476
CGN VE GE CDCG ++C + CCD+ TC+++ QCA G CC+ CQ + +
Sbjct: 403 DIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCAL-GECCEKCQFKKA 461
Query: 477 GWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWG 536
G CRP + +CDLPE C G S CP D +G PC G+ C+ G C + +QC LWG
Sbjct: 462 GMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWG 521
Query: 537 PG 538
PG
Sbjct: 522 PG 523
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
[Homo sapiens]
Length = 859
Score = 313 bits (801), Expect = 6e-85
Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)
Query: 77 GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136
G S IL+++ N +L+ + G V +G E+C YQG +RG S+V++ TC
Sbjct: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
Query: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185
GL G+ ++ PE + T ++ D + SR+ + L P ++
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
Query: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244
S KP ++ R R+V ETK +EL+IV DH +K+R H V
Sbjct: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
Query: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303
+ D ++ L R+ LV +E W + IS NP +TL F+ +RR + + D+ L
Sbjct: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
Query: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360
+G+ F G A ICS GGVN T ++ V ++A L H++G+ D L
Sbjct: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418
C C CIM + +LP F+ C+ L G G+CLF + L P
Sbjct: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
Query: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475
P CGN F+E GE+CDCG +CV CC C L +QC SDG CC+ C+ +P
Sbjct: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
Query: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535
G CR DCD+ E C G+SSQC P++ DG C G Q +C GRC + +QC+ +W
Sbjct: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
Query: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595
G + C + N G G+CG++ +++ C RD +CG L C P LG +
Sbjct: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
Query: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
+ T+ V G LNCS H+ L DV + GT CGP ++C++HRC V
Sbjct: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
Query: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701
C S C G+GVC + C C W DC T TG+ LS
Sbjct: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
Length = 769
Score = 312 bits (800), Expect = 7e-85
Identities = 240/727 (33%), Positives = 331/727 (45%), Gaps = 64/727 (8%)
Query: 9 LGLLGAGSPLPSWPLPNIGGTEEQQA-ESEKAPREPLEPQVLQDDLPISLKKVLQTSLPE 67
LG G L LP +GG + E + RE +V + L +++ P
Sbjct: 22 LGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV 81
Query: 68 PLR---IKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVR 124
L + + L+L N L+ + + +GT S G ++C YQG++R
Sbjct: 82 HLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAG-DHCYYQGKLR 140
Query: 125 GYAGSWVSICTCSGLRGLVVLTPERSYTLEQ----GP-GDLQGP--------PIISRIQD 171
G S+ ++ TC GL G V +Y +E GP G QGP P++
Sbjct: 141 GNPHSFAALSTCQGLHG-VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG 199
Query: 172 LHLPGHTCALSWRESVHTQKPPEHPL--GQRHIRRRRDVV-TETKTVELVIVADHSEAQK 228
PG A+ + + PP P +R +RR V +ETK VEL+++ DH ++
Sbjct: 200 CREPGCLFAVPAQSA-----PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQ 254
Query: 229 YRDFQHLL-NRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH 286
R L N V L D ++ LN R+ LV +E W D +++ + TL +
Sbjct: 255 MRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMV 314
Query: 287 WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSI 346
+RR L P D+ L +G +F + G A ICS GGVN + + V ++
Sbjct: 315 YRREGLPE--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAV--TL 370
Query: 347 AHELGHSLGL---DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALL 403
A LG +LG+ H C CP CIME + +LP FS CS + L
Sbjct: 371 AQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDTGFYLPR-KFSRCSIDEYNQFLQ 427
Query: 404 DGMGSCLFERLPSL--PPMAAFCGNMFVEPGEQCDCGFLDDCVDP---CCDSLTCQLRPG 458
+G GSCLF + L PP CGN FVE GE+CDCG + +C CC C L
Sbjct: 428 EGGGSCLFNKPLKLLDPPE---CGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHD 482
Query: 459 AQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAV 518
A C SDG CC+ C+ P G CR +CD+ E C GDSSQCPP++ DG C Q
Sbjct: 483 AMC-SDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGR 541
Query: 519 CMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAIC 578
C GRC + +QCQ LWG A A C + N G GSCGR SG +V C+ +D +C
Sbjct: 542 CYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLC 598
Query: 579 GQLQCQTGRTQPLLGS-IRDLLWETIDVNGTELNCSWVHLDL--GSDVAQPLLTLPGTAC 635
G L C P LG + D+ T G EL+C H+ L GSD++ GTAC
Sbjct: 599 GFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLS---YVEDGTAC 655
Query: 636 GPGLVCIDHRCQRVDLLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKA 690
GP ++C+DHRC C R C HGVC + C C+ W DC+
Sbjct: 656 GPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPL 715
Query: 691 TSSLTTG 697
+S TG
Sbjct: 716 PTSPPTG 722
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 295 bits (755), Expect = 1e-79
Identities = 195/640 (30%), Positives = 300/640 (46%), Gaps = 50/640 (7%)
Query: 72 KLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWV 131
++E G IL+L+ N L+ + Y+ +G S+G E+C Y G +RG S V
Sbjct: 154 QIEAFGSKFILDLILNNGLLSSDYVEIHYE-NGKPQYSKGG--EHCYYHGSIRGVKDSKV 210
Query: 132 SICTCSGLRGLV-------VLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWR 184
++ TC+GL G+ ++ P E+ G P II + L G
Sbjct: 211 ALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGR---PHIIQKT----LAGQYS--KQM 261
Query: 185 ESVHTQKPPEHPL---------GQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQ-H 234
+++ ++ + P +R + R + E K +EL+IV DH +K+R H
Sbjct: 262 KNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAH 321
Query: 235 LLNRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLL 293
N V L+D+ ++ LN RV LV +E WT++D ++I+ NP L F +R+
Sbjct: 322 TNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI-- 379
Query: 294 PRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHS 353
+ D+ L++ +F ++ +CS + GV ++ + VA ++ L +
Sbjct: 380 -KQHADAVHLISRVTFHYKRSSLSYFGGVCSR--TRGVGVNEYGLPMAVAQVLSQSLAQN 436
Query: 354 LGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER 413
LG+ + C CIME T FS CS L G G+CLF R
Sbjct: 437 LGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGGACLFNR 495
Query: 414 LPSLPPMAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQN--C 471
P+ CGN +VE GE+CDCGF +C CC C L GA C SDGPCC N C
Sbjct: 496 -PTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHC-SDGPCCNNTSC 551
Query: 472 QLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQC 531
+P G++CR +CD+ E+C GDS QCPP++ DG C Q C +G C + QC
Sbjct: 552 LFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQC 611
Query: 532 QSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPL 591
Q +WG A + C + NT G G+CG++ ++ C+ D CG L C P
Sbjct: 612 QYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKD-GDRWIQCSKHDVFCGFLLCTNLTRAPR 670
Query: 592 LGSIR-DLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
+G ++ +++ + G ++CS H+ L D + GT CGP ++C+D +C ++
Sbjct: 671 IGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYVE-DGTPCGPSMMCLDRKCLQIQ 729
Query: 651 LLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCT 685
L C C GHGVC + C C+ WA DC+
Sbjct: 730 ALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCS 769
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 288 bits (737), Expect = 1e-77
Identities = 197/626 (31%), Positives = 297/626 (47%), Gaps = 34/626 (5%)
Query: 68 PLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYA 127
P+ L+L G H+L L R L+P + + G + + ++C Y G V+
Sbjct: 61 PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120
Query: 128 GSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
S +I TC GLRG+ + + Y +E ++ ++ C LS E
Sbjct: 121 DSKATISTCMGGLRGVFNIDAKH-YQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI 179
Query: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
P E+ + +R K +EL+++ D S +YR + L++ + A+LL
Sbjct: 180 EWQMAPYEN---KARLRDFPGSYKHPKYLELILLFDQS---RYRFVNNNLSQVIHDAILL 233
Query: 247 ----DTFFRPLNVRVALVGLEAWTQRDLVEIS-PNPAVTLENFLHWRRAHLLPRLPHDSA 301
DT+F+ + +R+ L LE WT + + + P A L F+ ++++ L RL D A
Sbjct: 234 TGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWA 293
Query: 302 QLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLP 361
L ++ +CS +++G V+ T+IL A+ AHELGH++G+ HD
Sbjct: 294 HLYLQRKYNDALAWSF--GKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD-- 349
Query: 362 GNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMA 421
C C G CIM + FSNCS + K + G +CL +P L +
Sbjct: 350 EQYCQCRGRL---NCIMGSGRT-----GFSNCSYISFFKHISSG-ATCL-NNIPGLGYVL 399
Query: 422 AFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
CGN VE E+CDCG ++C D CC S C+L+PGA C S G CC +C+ RPSG+ C
Sbjct: 400 KRCGNKIVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANC-SIGLCCHDCRFRPSGYVC 457
Query: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
R +CDL E+C G+SS CP DV DG PC + C C S QCQS++GP A
Sbjct: 458 RQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAM 516
Query: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
A C N G+ FG+C ++ C ++ICG+LQC T P L ++
Sbjct: 517 EAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIS 576
Query: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTL--PGTACGPGLVCIDHRCQRVDLLGAQECR 658
+ + HL + + P L + GT+CG G VC C +L
Sbjct: 577 THLQAENLMCWGTGYHLSM-KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLP 635
Query: 659 SKCHGHGVCDSNRHCYCEEGWAPPDC 684
KC+ GVC++ ++C+C GWAPP C
Sbjct: 636 EKCNTRGVCNNRKNCHCMYGWAPPFC 661
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 286 bits (732), Expect = 6e-77
Identities = 201/632 (31%), Positives = 294/632 (46%), Gaps = 39/632 (6%)
Query: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
P L L G +I+ + N+ L + Y + + ++C Y G V G
Sbjct: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEG 167
Query: 126 YAGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGP--PIISRIQ--DLHLPGHTCAL 181
S V++ TCSG G + + E P + ++ +I D P C L
Sbjct: 168 VPESLVALSTCSG--GFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGL 225
Query: 182 SWRESVHTQKPPEHPLGQRHIRRRRDVV---TETKTVELVIVADHSEAQ-KYRDFQHLLN 237
+ + H E L ++ V T + VELV+V D+ + + +
Sbjct: 226 TEEKIAHQM---ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQH 282
Query: 238 RTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLP 297
V ++D+F+ PL V V L G++ WT + + S + LE+F W+ +L RL
Sbjct: 283 EVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQ 342
Query: 298 HDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLD 357
HD A L + G +G+A IC F+ GV++ ++ A ++ HELGH+LG+
Sbjct: 343 HDVAHLFIKDT-QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQ 401
Query: 358 HDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL 417
HD C C + CIM A FSNCS + + G C+ + P
Sbjct: 402 HDTQW--CVCE----LQWCIMHAYRKVTT--KFSNCSYAQYWDSTISS-GLCI--QPPPY 450
Query: 418 PP---MAAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQL 473
P +CGN+ VE GE+CDCG + C DPCC L C L PGA CA G CC++C+
Sbjct: 451 PGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCC-LLNCTLHPGAACAF-GICCKDCKF 508
Query: 474 RPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQS 533
PSG CR G+CDLPE+C G S QCP DV + DG C A C C ++ QC+
Sbjct: 509 LPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKE 567
Query: 534 LWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLG 593
++G A+ A+ C Q NT+GN FG CG +YV C D +CG++QC+ P L
Sbjct: 568 IFGQDARSASQSCYQEINTQGNRFGHCG-IVGTTYVKCWTPDIMCGRVQCENVGVIPNL- 625
Query: 594 SIRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG 653
I + +N T C LG + GT CGP +CI +C + L
Sbjct: 626 -IEHSTVQQFHLNDT--TCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHL- 681
Query: 654 AQECRSK-CHGHGVCDSNRHCYCEEGWAPPDC 684
+Q C+ K C+ G+C++ +HC+C WAPP C
Sbjct: 682 SQACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 285 bits (729), Expect = 1e-76
Identities = 207/693 (29%), Positives = 320/693 (46%), Gaps = 45/693 (6%)
Query: 66 PEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRG 125
P L L G H++ + + LV + Y + + + ++C Y G V G
Sbjct: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEG 117
Query: 126 YAGSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQ--DLHLPGHTCALS 182
S V C G RG++ ++ +Y +E ++ ++ + P C L+
Sbjct: 118 APESLVVFSACFGGFRGVLKISG-LTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLT 176
Query: 183 WRESVHTQKPPEHPLGQR-HIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTL 240
+E Q E + D T +ELV+V +H + +
Sbjct: 177 EKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVF 236
Query: 241 EVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS 300
V ++D+ ++ L + L+G+E W Q ++ ++ V L +F W++ L +L HD+
Sbjct: 237 LVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTSIEQV-LNDFSQWKQISL-SQLQHDA 294
Query: 301 AQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDL 360
A + S +G+A IC P GV+ + A+++AHELGH+LG+ HD
Sbjct: 295 AHMFIKNSLIS-ILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD- 352
Query: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPP- 419
C C + CIM +T +P F+NCS K L+ GSCL PP
Sbjct: 353 -EEFCFCG----ERGCIM--NTFRVPAEKFTNCSYADFMKTTLN-QGSCLHN-----PPR 399
Query: 420 -----MAAFCGNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
M CGN VE EQCDCG + C C L C LRPGA CA G CC++C+
Sbjct: 400 LGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF-GLCCKDCKFM 458
Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
PSG CR +CDLPE+C G S QCP D + DG PC+ A C RC ++ Q C+ +
Sbjct: 459 PSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNNHDQHCREI 517
Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
+G A+ A+ C + N++GN FG CG N + +Y+ C D CG++QC+ R PLL
Sbjct: 518 FGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENVRDIPLLQD 576
Query: 595 IRDLLWETIDVNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654
L + +NG + C + L +++ GT CGPG +CI +C + +L
Sbjct: 577 HFTL--QHTHING--VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSH 632
Query: 655 QECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ------LKATSSLTTGLLLSLLVLLVL 708
C+ G+C++ HC+C GW+PP C + +S G+ L L+V+ L
Sbjct: 633 VCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSL 692
Query: 709 VMLGASYWYRARLHQRLCQLKGPTCQYRAAQSG 741
+L ++ + L L Q GP + +A SG
Sbjct: 693 SVL--TFLFTVGLLMYLRQCSGPK-ETKAHSSG 722
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 273 bits (699), Expect = 4e-73
Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)
Query: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
L G HI+ + + L + Y G + + NC Y G V G S VS
Sbjct: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
Query: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
+ TC G ++ L T + + Q + S + T
Sbjct: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
Query: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
C + + E + TQK + H R VE+V+V D+ +Y R+ LL
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
Query: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
+ ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+
Sbjct: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
Query: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+
Sbjct: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
Query: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
+HD ++C C P CIM P FSNCS + ++ CL E + +
Sbjct: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
Query: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+
Sbjct: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ +
Sbjct: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
+G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P +
Sbjct: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
Query: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
+ W + ++ C W HL + G D+ + GT CG +CI C +
Sbjct: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
Query: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
+L + + C+ G+C++ HC+C W PP+C + K L
Sbjct: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
Query: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
LL++++ ++L Y RLC+ P + + Q+ ++ QR R +
Sbjct: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727
Query: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818
S P PS+ PP S+ + + PP P + P V +SQ PP
Sbjct: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781
Query: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853
P + PQ P + P ++PS+ PP
Sbjct: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 273 bits (699), Expect = 4e-73
Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)
Query: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
L G HI+ + + L + Y G + + NC Y G V G S VS
Sbjct: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
Query: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
+ TC G ++ L T + + Q + S + T
Sbjct: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
Query: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
C + + E + TQK + H R VE+V+V D+ +Y R+ LL
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
Query: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
+ ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+
Sbjct: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
Query: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+
Sbjct: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
Query: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
+HD ++C C P CIM P FSNCS + ++ CL E + +
Sbjct: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
Query: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+
Sbjct: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ +
Sbjct: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
+G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P +
Sbjct: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
Query: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
+ W + ++ C W HL + G D+ + GT CG +CI C +
Sbjct: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
Query: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
+L + + C+ G+C++ HC+C W PP+C + K L
Sbjct: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
Query: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
LL++++ ++L Y RLC+ P + + Q+ ++ QR R +
Sbjct: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727
Query: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818
S P PS+ PP S+ + + PP P + P V +SQ PP
Sbjct: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781
Query: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853
P + PQ P + P ++PS+ PP
Sbjct: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 273 bits (699), Expect = 4e-73
Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)
Query: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
L G HI+ + + L + Y G + + NC Y G V G S VS
Sbjct: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
Query: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
+ TC G ++ L T + + Q + S + T
Sbjct: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
Query: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
C + + E + TQK + H R VE+V+V D+ +Y R+ LL
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
Query: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
+ ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+
Sbjct: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
Query: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+
Sbjct: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
Query: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
+HD ++C C P CIM P FSNCS + ++ CL E + +
Sbjct: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
Query: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+
Sbjct: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ +
Sbjct: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
+G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P +
Sbjct: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
Query: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
+ W + ++ C W HL + G D+ + GT CG +CI C +
Sbjct: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
Query: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
+L + + C+ G+C++ HC+C W PP+C + K L
Sbjct: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
Query: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
LL++++ ++L Y RLC+ P + + Q+ ++ QR R +
Sbjct: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727
Query: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818
S P PS+ PP S+ + + PP P + P V +SQ PP
Sbjct: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781
Query: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853
P + PQ P + P ++PS+ PP
Sbjct: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 273 bits (699), Expect = 4e-73
Identities = 220/815 (26%), Positives = 350/815 (42%), Gaps = 88/815 (10%)
Query: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
L G HI+ + + L + Y G + + NC Y G V G S VS
Sbjct: 56 LPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVS 115
Query: 133 ICTCSG--------------LRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHT 178
+ TC G ++ L T + + Q + S + T
Sbjct: 116 LSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---T 172
Query: 179 CALSWRESVH-TQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLL 236
C + + E + TQK + H R VE+V+V D+ +Y R+ LL
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFR----------IVEIVVVIDNYLYIRYERNDSKLL 222
Query: 237 NRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRL 296
+ ++D+ + V+V L GLE WT ++L+ + + ++ + W+ ++ PR+
Sbjct: 223 EDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKNLIVVD-DVRKSVHLYCKWKSENITPRM 281
Query: 297 PHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGL 356
HD++ L T G + G+ +C+P S + + ++ + ++AH LGH+LG+
Sbjct: 282 QHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM 340
Query: 357 DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPS 416
+HD ++C C P CIM P FSNCS + ++ CL E + +
Sbjct: 341 NHD--EDTCRCSQPR----CIMHEGNP--PITKFSNCSYGDFWEYTVERT-KCLLETVHT 391
Query: 417 LPPM-AAFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLR 474
CGN VE GE+CDCG L C DPCC S C L G+ CA G CC++C+
Sbjct: 392 KDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAF-GLCCKDCKFL 449
Query: 475 PSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534
PSG CR +CDLPE+C G S +CP D + DG PC + C C +QC+ +
Sbjct: 450 PSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRI 508
Query: 535 WGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGS 594
+G GA A+ C + NT G+ G CG + +Y+ C D CG++QC+ P +
Sbjct: 509 FGAGANTASETCYKELNTLGDRVGHCGIK-NATYIKCNISDVQCGRIQCENVTEIPNMSD 567
Query: 595 IRDLLWETIDVNGTELNCSW---VHLDL-GSDVAQPLLTLPGTACGPGLVCIDHRCQRVD 650
+ W + ++ C W HL + G D+ + GT CG +CI C +
Sbjct: 568 HTTVHWARFN----DIMC-WSTDYHLGMKGPDIGE---VKDGTECGIDHICIHRHCVHIT 619
Query: 651 LLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDCTTQ-----------LKATSSLTTGLL 699
+L + + C+ G+C++ HC+C W PP+C + K L
Sbjct: 620 ILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYL 679
Query: 700 LSLLVLLVLVMLGASYWYRARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTK 759
LL++++ ++L Y RLC+ P + + Q+ ++ QR R +
Sbjct: 680 CILLLIVLFILLCCLY--------RLCKKSKPIKKQQDVQTPSAKEEEKIQR----RPHE 727
Query: 760 ASALSFP-APPSRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPR 818
S P PS+ PP S+ + + PP P + P V +SQ PP
Sbjct: 728 LPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTPSQSQPRVMPSQSQ------PPV 781
Query: 819 KPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPP 853
P + PQ P + P ++PS+ PP
Sbjct: 782 MPSQSHPQLTPSQSQPPVTPSQRQPQLMPSQSQPP 816
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.452
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,946,923
Number of Sequences: 37866
Number of extensions: 2891244
Number of successful extensions: 28561
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 326
Number of HSP's successfully gapped in prelim test: 1416
Number of HSP's that attempted gapping in prelim test: 14721
Number of HSP's gapped (non-prelim): 8802
length of query: 862
length of database: 18,247,518
effective HSP length: 111
effective length of query: 751
effective length of database: 14,044,392
effective search space: 10547338392
effective search space used: 10547338392
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.