Search of human proteins with 4585710

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
         (769 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s...  1632   0.0  
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...   853   0.0  
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...   853   0.0  
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...   853   0.0  
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...   849   0.0  
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...   849   0.0  
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   753   0.0  
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   358   8e-99
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   343   5e-94
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   340   3e-93
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   340   3e-93
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   333   4e-91
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   325   1e-88
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   312   7e-85
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   312   7e-85
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   312   7e-85
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   312   7e-85
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...   312   7e-85
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   312   7e-85
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   295   1e-79
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   293   3e-79
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   266   4e-71
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...   264   2e-70
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...   261   2e-69
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   259   7e-69
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   253   5e-67
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   253   5e-67
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   253   5e-67
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   253   5e-67
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi...   249   9e-66

>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
           sapiens]
          Length = 769

 Score = 1632 bits (4227), Expect = 0.0
 Identities = 769/769 (100%), Positives = 769/769 (100%)

Query: 1   MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGG 60
           MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGG
Sbjct: 1   MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGG 60

Query: 61  EVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSRE 120
           EVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSRE
Sbjct: 61  EVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSRE 120

Query: 121 GTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAP 180
           GTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAP
Sbjct: 121 GTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAP 180

Query: 181 QGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKY 240
           QGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKY
Sbjct: 181 QGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKY 240

Query: 241 VELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQ 300
           VELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQ
Sbjct: 241 VELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQ 300

Query: 301 VQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEY 360
           VQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEY
Sbjct: 301 VQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEY 360

Query: 361 GNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSID 420
           GNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSID
Sbjct: 361 GNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSID 420

Query: 421 EYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLT 480
           EYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLT
Sbjct: 421 EYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLT 480

Query: 481 HDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQG 540
           HDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQG
Sbjct: 481 HDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQG 540

Query: 541 RCYGGRCKTRDRQCQVLWGHAAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGF 600
           RCYGGRCKTRDRQCQVLWGHAAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGF
Sbjct: 541 RCYGGRCKTRDRQCQVLWGHAAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGF 600

Query: 601 LLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNML 660
           LLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNML
Sbjct: 601 LLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNML 660

Query: 661 CLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPP 720
           CLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPP
Sbjct: 661 CLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPP 720

Query: 721 TGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA 769
           TGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA
Sbjct: 721 TGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA 769


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score =  853 bits (2204), Expect = 0.0
 Identities = 407/724 (56%), Positives = 516/724 (71%), Gaps = 10/724 (1%)

Query: 50  PSRLVRESSG-GEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLL 108
           P RL+  S G  E R   LDTRVR +  G    H+ Q SF + AF ++F LD+ LNH LL
Sbjct: 52  PLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLL 111

Query: 109 SSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIV 168
           SS+Y+ERH    G T    G G+HCYYQG +RGNP SF ALSTC GLHG+F DGN TY++
Sbjct: 112 SSEYIERHIEHGGKTVEVKG-GEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLI 170

Query: 169 EPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGC--REPGCLFAVPAQSAPPNRPRLRRKRQ 226
           EP+E        +    H +Y++ L    L     E   +   P++     RP+ R KRQ
Sbjct: 171 EPEENDT---TQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPK-RSKRQ 226

Query: 227 VRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIV 286
           +RR    V  ETKY+EL+++NDH +F++ R SVV T+ +AKSVVN+AD+IYK+QL TRIV
Sbjct: 227 LRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIV 286

Query: 287 LVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVG 346
           LVAMETWA  +K  + ++ L TL   M YRR+ + E SDA HLFSG  F+S+ SGAAY+G
Sbjct: 287 LVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG 346

Query: 347 GICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDT 406
           GICSL  GGGVNE+G    MAVTLAQ+L  N+G++ +K + ++G+CKC D W GCIM DT
Sbjct: 347 GICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDT 406

Query: 407 GFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQEC 466
           G+YLP+KF++C+I+EY+ FL  GGG+CLFNKP KLLDPPECGNGF+E GEECDCG+  EC
Sbjct: 407 GYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAEC 466

Query: 467 SRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPN 526
              G  CCKKCTLT D+ CSDGLCC++CK++P G  CREAVN+CDI ETC+G+SSQC PN
Sbjct: 467 VLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPN 526

Query: 527 LHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGH--AAADRFCYEKLNVEGTERGSCGRK 584
           +HK+DGY CD  QG C+GGRCKTRDRQC+ +WG    A+D++CYEKLN+EGTE+G+CG+ 
Sbjct: 527 IHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKD 586

Query: 585 GSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGS 644
              W+QC+K+DVLCG+LLC NI   PRLG+L G+I+S     QG+ L+C GGHV+L +  
Sbjct: 587 KDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV 646

Query: 645 DLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDW 704
           DL YVEDGT CGP M+CL+HRCLP ++FNFSTC  S E  ICS +GVCSNE KC+C   W
Sbjct: 647 DLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHW 706

Query: 705 TGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRG 764
            G DC+ + P      TG T    G +GTNIIIG IAG +LV A++LG T WG+KN R  
Sbjct: 707 IGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ 766

Query: 765 RSGG 768
           RS G
Sbjct: 767 RSNG 770


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score =  853 bits (2204), Expect = 0.0
 Identities = 407/724 (56%), Positives = 516/724 (71%), Gaps = 10/724 (1%)

Query: 50  PSRLVRESSG-GEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLL 108
           P RL+  S G  E R   LDTRVR +  G    H+ Q SF + AF ++F LD+ LNH LL
Sbjct: 52  PLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLL 111

Query: 109 SSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIV 168
           SS+Y+ERH    G T    G G+HCYYQG +RGNP SF ALSTC GLHG+F DGN TY++
Sbjct: 112 SSEYIERHIEHGGKTVEVKG-GEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLI 170

Query: 169 EPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGC--REPGCLFAVPAQSAPPNRPRLRRKRQ 226
           EP+E        +    H +Y++ L    L     E   +   P++     RP+ R KRQ
Sbjct: 171 EPEENDT---TQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPK-RSKRQ 226

Query: 227 VRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIV 286
           +RR    V  ETKY+EL+++NDH +F++ R SVV T+ +AKSVVN+AD+IYK+QL TRIV
Sbjct: 227 LRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIV 286

Query: 287 LVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVG 346
           LVAMETWA  +K  + ++ L TL   M YRR+ + E SDA HLFSG  F+S+ SGAAY+G
Sbjct: 287 LVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG 346

Query: 347 GICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDT 406
           GICSL  GGGVNE+G    MAVTLAQ+L  N+G++ +K + ++G+CKC D W GCIM DT
Sbjct: 347 GICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDT 406

Query: 407 GFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQEC 466
           G+YLP+KF++C+I+EY+ FL  GGG+CLFNKP KLLDPPECGNGF+E GEECDCG+  EC
Sbjct: 407 GYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAEC 466

Query: 467 SRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPN 526
              G  CCKKCTLT D+ CSDGLCC++CK++P G  CREAVN+CDI ETC+G+SSQC PN
Sbjct: 467 VLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPN 526

Query: 527 LHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGH--AAADRFCYEKLNVEGTERGSCGRK 584
           +HK+DGY CD  QG C+GGRCKTRDRQC+ +WG    A+D++CYEKLN+EGTE+G+CG+ 
Sbjct: 527 IHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKD 586

Query: 585 GSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGS 644
              W+QC+K+DVLCG+LLC NI   PRLG+L G+I+S     QG+ L+C GGHV+L +  
Sbjct: 587 KDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV 646

Query: 645 DLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDW 704
           DL YVEDGT CGP M+CL+HRCLP ++FNFSTC  S E  ICS +GVCSNE KC+C   W
Sbjct: 647 DLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHW 706

Query: 705 TGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRG 764
            G DC+ + P      TG T    G +GTNIIIG IAG +LV A++LG T WG+KN R  
Sbjct: 707 IGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ 766

Query: 765 RSGG 768
           RS G
Sbjct: 767 RSNG 770


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score =  853 bits (2204), Expect = 0.0
 Identities = 407/724 (56%), Positives = 516/724 (71%), Gaps = 10/724 (1%)

Query: 50  PSRLVRESSG-GEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLL 108
           P RL+  S G  E R   LDTRVR +  G    H+ Q SF + AF ++F LD+ LNH LL
Sbjct: 52  PLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLL 111

Query: 109 SSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIV 168
           SS+Y+ERH    G T    G G+HCYYQG +RGNP SF ALSTC GLHG+F DGN TY++
Sbjct: 112 SSEYIERHIEHGGKTVEVKG-GEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLI 170

Query: 169 EPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGC--REPGCLFAVPAQSAPPNRPRLRRKRQ 226
           EP+E        +    H +Y++ L    L     E   +   P++     RP+ R KRQ
Sbjct: 171 EPEENDT---TQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPK-RSKRQ 226

Query: 227 VRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIV 286
           +RR    V  ETKY+EL+++NDH +F++ R SVV T+ +AKSVVN+AD+IYK+QL TRIV
Sbjct: 227 LRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIV 286

Query: 287 LVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVG 346
           LVAMETWA  +K  + ++ L TL   M YRR+ + E SDA HLFSG  F+S+ SGAAY+G
Sbjct: 287 LVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG 346

Query: 347 GICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDT 406
           GICSL  GGGVNE+G    MAVTLAQ+L  N+G++ +K + ++G+CKC D W GCIM DT
Sbjct: 347 GICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDT 406

Query: 407 GFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQEC 466
           G+YLP+KF++C+I+EY+ FL  GGG+CLFNKP KLLDPPECGNGF+E GEECDCG+  EC
Sbjct: 407 GYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAEC 466

Query: 467 SRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPN 526
              G  CCKKCTLT D+ CSDGLCC++CK++P G  CREAVN+CDI ETC+G+SSQC PN
Sbjct: 467 VLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPN 526

Query: 527 LHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGH--AAADRFCYEKLNVEGTERGSCGRK 584
           +HK+DGY CD  QG C+GGRCKTRDRQC+ +WG    A+D++CYEKLN+EGTE+G+CG+ 
Sbjct: 527 IHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKD 586

Query: 585 GSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGS 644
              W+QC+K+DVLCG+LLC NI   PRLG+L G+I+S     QG+ L+C GGHV+L +  
Sbjct: 587 KDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV 646

Query: 645 DLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDW 704
           DL YVEDGT CGP M+CL+HRCLP ++FNFSTC  S E  ICS +GVCSNE KC+C   W
Sbjct: 647 DLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHW 706

Query: 705 TGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRG 764
            G DC+ + P      TG T    G +GTNIIIG IAG +LV A++LG T WG+KN R  
Sbjct: 707 IGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ 766

Query: 765 RSGG 768
           RS G
Sbjct: 767 RSNG 770


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score =  849 bits (2194), Expect = 0.0
 Identities = 405/721 (56%), Positives = 514/721 (71%), Gaps = 10/721 (1%)

Query: 50  PSRLVRESSG-GEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLL 108
           P RL+  S G  E R   LDTRVR +  G    H+ Q SF + AF ++F LD+ LNH LL
Sbjct: 52  PLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLL 111

Query: 109 SSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIV 168
           SS+Y+ERH    G T    G G+HCYYQG +RGNP SF ALSTC GLHG+F DGN TY++
Sbjct: 112 SSEYIERHIEHGGKTVEVKG-GEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLI 170

Query: 169 EPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGC--REPGCLFAVPAQSAPPNRPRLRRKRQ 226
           EP+E        +    H +Y++ L    L     E   +   P++     RP+ R KRQ
Sbjct: 171 EPEENDT---TQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPK-RSKRQ 226

Query: 227 VRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIV 286
           +RR    V  ETKY+EL+++NDH +F++ R SVV T+ +AKSVVN+AD+IYK+QL TRIV
Sbjct: 227 LRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIV 286

Query: 287 LVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVG 346
           LVAMETWA  +K  + ++ L TL   M YRR+ + E SDA HLFSG  F+S+ SGAAY+G
Sbjct: 287 LVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG 346

Query: 347 GICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDT 406
           GICSL  GGGVNE+G    MAVTLAQ+L  N+G++ +K + ++G+CKC D W GCIM DT
Sbjct: 347 GICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDT 406

Query: 407 GFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQEC 466
           G+YLP+KF++C+I+EY+ FL  GGG+CLFNKP KLLDPPECGNGF+E GEECDCG+  EC
Sbjct: 407 GYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAEC 466

Query: 467 SRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPN 526
              G  CCKKCTLT D+ CSDGLCC++CK++P G  CREAVN+CDI ETC+G+SSQC PN
Sbjct: 467 VLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPN 526

Query: 527 LHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGH--AAADRFCYEKLNVEGTERGSCGRK 584
           +HK+DGY CD  QG C+GGRCKTRDRQC+ +WG    A+D++CYEKLN+EGTE+G+CG+ 
Sbjct: 527 IHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKD 586

Query: 585 GSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGS 644
              W+QC+K+DVLCG+LLC NI   PRLG+L G+I+S     QG+ L+C GGHV+L +  
Sbjct: 587 KDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV 646

Query: 645 DLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDW 704
           DL YVEDGT CGP M+CL+HRCLP ++FNFSTC  S E  ICS +GVCSNE KC+C   W
Sbjct: 647 DLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHW 706

Query: 705 TGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRG 764
            G DC+ + P      TG T    G +GTNIIIG IAG +LV A++LG T WG+KN R  
Sbjct: 707 IGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ 766

Query: 765 R 765
           R
Sbjct: 767 R 767


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score =  849 bits (2194), Expect = 0.0
 Identities = 405/721 (56%), Positives = 514/721 (71%), Gaps = 10/721 (1%)

Query: 50  PSRLVRESSG-GEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLL 108
           P RL+  S G  E R   LDTRVR +  G    H+ Q SF + AF ++F LD+ LNH LL
Sbjct: 52  PLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLL 111

Query: 109 SSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIV 168
           SS+Y+ERH    G T    G G+HCYYQG +RGNP SF ALSTC GLHG+F DGN TY++
Sbjct: 112 SSEYIERHIEHGGKTVEVKG-GEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLI 170

Query: 169 EPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGC--REPGCLFAVPAQSAPPNRPRLRRKRQ 226
           EP+E        +    H +Y++ L    L     E   +   P++     RP+ R KRQ
Sbjct: 171 EPEENDT---TQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPK-RSKRQ 226

Query: 227 VRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIV 286
           +RR    V  ETKY+EL+++NDH +F++ R SVV T+ +AKSVVN+AD+IYK+QL TRIV
Sbjct: 227 LRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIV 286

Query: 287 LVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVG 346
           LVAMETWA  +K  + ++ L TL   M YRR+ + E SDA HLFSG  F+S+ SGAAY+G
Sbjct: 287 LVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG 346

Query: 347 GICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDT 406
           GICSL  GGGVNE+G    MAVTLAQ+L  N+G++ +K + ++G+CKC D W GCIM DT
Sbjct: 347 GICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDT 406

Query: 407 GFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQEC 466
           G+YLP+KF++C+I+EY+ FL  GGG+CLFNKP KLLDPPECGNGF+E GEECDCG+  EC
Sbjct: 407 GYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAEC 466

Query: 467 SRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPN 526
              G  CCKKCTLT D+ CSDGLCC++CK++P G  CREAVN+CDI ETC+G+SSQC PN
Sbjct: 467 VLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPN 526

Query: 527 LHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGH--AAADRFCYEKLNVEGTERGSCGRK 584
           +HK+DGY CD  QG C+GGRCKTRDRQC+ +WG    A+D++CYEKLN+EGTE+G+CG+ 
Sbjct: 527 IHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKD 586

Query: 585 GSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGS 644
              W+QC+K+DVLCG+LLC NI   PRLG+L G+I+S     QG+ L+C GGHV+L +  
Sbjct: 587 KDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV 646

Query: 645 DLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDW 704
           DL YVEDGT CGP M+CL+HRCLP ++FNFSTC  S E  ICS +GVCSNE KC+C   W
Sbjct: 647 DLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHW 706

Query: 705 TGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRG 764
            G DC+ + P      TG T    G +GTNIIIG IAG +LV A++LG T WG+KN R  
Sbjct: 707 IGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ 766

Query: 765 R 765
           R
Sbjct: 767 R 767


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  753 bits (1943), Expect = 0.0
 Identities = 383/727 (52%), Positives = 477/727 (65%), Gaps = 20/727 (2%)

Query: 46  EVTEPSRLVRE-SSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELN 104
           E+T PSRL+   +   E     LDT+ R +      VHLAQ SF I AF S F LDL LN
Sbjct: 110 EITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILN 169

Query: 105 HHLLSSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNL 164
           + LLSS YVE H+   G  Q+S G G+HCYY G +RG   S  ALSTC GLHG+F D   
Sbjct: 170 NGLLSSDYVEIHYEN-GKPQYSKG-GEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDDTF 227

Query: 165 TYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRK 224
            Y++EP E+           PH+I +T  L      ++   L        P        K
Sbjct: 228 VYMIEPLELVHD--EKSTGRPHIIQKT--LAGQYS-KQMKNLTMERGDQWPFLSELQWLK 282

Query: 225 RQVRRGHPT--VHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLN 282
           R+ R  +P+  +  E KY+EL+++NDH+ +++ R S   T+NFAKSVVNL D IYKEQLN
Sbjct: 283 RRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLN 342

Query: 283 TRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGA 342
           TR+VLVA+ETW + D+I +  + ++ L     YR+  + + +DA HL S  TF    S  
Sbjct: 343 TRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR-IKQHADAVHLISRVTFHYKRSSL 401

Query: 343 AYVGGICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCI 402
           +Y GG+CS + G GVNEYG   A+A  L+Q+L QNLG+ W    S    C C + W GCI
Sbjct: 402 SYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPS-SRKPKCDCTESWGGCI 460

Query: 403 MEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGS 462
           ME+TG    RKFS+CSI EY  FLQ GGG+CLFN+P KL +P ECGNG+VEAGEECDCG 
Sbjct: 461 MEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGF 520

Query: 463 VQECSRAGGNCCKKCTLTHDAMCSDGLCCRR--CKYEPRGVSCREAVNECDIAETCTGDS 520
             EC    G CCKKC+L++ A CSDG CC    C ++PRG  CR+AVNECDI E CTGDS
Sbjct: 521 HVECY---GLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDS 577

Query: 521 SQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAAA--DRFCYEKLNVEGTER 578
            QCPPNLHK DGY C+  QGRCY G CKTRD QCQ +WG  AA  D+FCYEKLN EGTE+
Sbjct: 578 GQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEK 637

Query: 579 GSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHV 638
           G+CG+ G  W+QCSK DV CGFLLC N++ APR+G L G+I   +FYHQG+ +DC G HV
Sbjct: 638 GNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHV 697

Query: 639 QLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKC 698
            L D +D+ YVEDGT CGP+M+CLD +CL   A N S+CP   + ++CS HGVCSNE  C
Sbjct: 698 VLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATC 757

Query: 699 ICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGF 758
           IC   W G DCSI +P+    P  + E  KGPS TN+IIGSIAGA+LVAAIVLGGTGWGF
Sbjct: 758 ICDFTWAGTDCSIRDPVRNLHPP-KDEGPKGPSATNLIIGSIAGAILVAAIVLGGTGWGF 816

Query: 759 KNIRRGR 765
           KN+++ R
Sbjct: 817 KNVKKRR 823


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  358 bits (920), Expect = 8e-99
 Identities = 251/752 (33%), Positives = 347/752 (46%), Gaps = 66/752 (8%)

Query: 26  GPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV---H 82
           G AGA R   L     P  P         R S  G  + Q  +  + Q      PV   H
Sbjct: 3   GGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQH-ELIIPQWKTSESPVREKH 61

Query: 83  LAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGA-GDHCYYQGKLRG 141
             +    + A      LDLE N  L +  Y E H++  G  Q +T    DHC+Y G +R 
Sbjct: 62  PLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRE 121

Query: 142 NPHSFAALSTCQGLHGVFS-DGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGC 200
              S   LSTC+G+ G+ +   NL+Y++EP         P     HLIYR+  L  P G 
Sbjct: 122 TELSSVTLSTCRGIRGLITVSSNLSYVIEP--------LPDSKGQHLIYRSEHLKPPPG- 172

Query: 201 REPGCLFAVPAQSAPPNRP-----RLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQM 255
               C F     S P  R        + K++ RR      +  KYVEL ++ D+  F++ 
Sbjct: 173 ---NCGFE---HSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKN 226

Query: 256 RQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVY 315
           R+    T +    + N  D  Y+  LN RI LV +E W  G+  +V ++   TL   + +
Sbjct: 227 RRDQDATKHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSW 285

Query: 316 RREGLPEP-SDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVN--EYGNMGAMAVTLAQ 372
           RR+ L +   D   L +G +F  T+ G A +  +CS+   GGVN     N   +A T+A 
Sbjct: 286 RRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAH 345

Query: 373 TLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMED-TGFYLPRKFSRCSIDEYNQFLQEGGG 431
            +G N GM       SA  C       GCIM   TG   P+ F+ C+  E +++LQ GGG
Sbjct: 346 EMGHNFGMT----HDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGG 401

Query: 432 SCLFNKP--LKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCK--KCTLTHDAMCSD 487
            CL N P    L     CGNG++E GEECDCG  +EC+     CC    CTL   A C+ 
Sbjct: 402 MCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNP---CCNASNCTLRPGAECAH 458

Query: 488 GLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRC 547
           G CC +CK    G  CRE   +CD+ E CTG S  CP N +++DG  C+  Q  CY G C
Sbjct: 459 GSCCHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMC 518

Query: 548 KTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLCGFLLCV 604
            T   QCQ LWG  A  A   C+EK+NV G   G+CG+  +G   +C+ +D  CG + C 
Sbjct: 519 LTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQ 578

Query: 605 NISGAPRLGDLVGDISSVTFYHQGKELDCRGGHV-----QLADGSDLSYVEDGTACGPNM 659
           +    P   + V      T    G+++ CRG HV     +  D  D   V  GT CG N 
Sbjct: 579 SSEARPLESNAVP--IDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNH 636

Query: 660 LCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSP 719
           +C + +C   S F    C   G++  C+ HGVC+N   C C P W    C+      T  
Sbjct: 637 ICFEGQCRNTSFFETEGC---GKK--CNGHGVCNNNQNCHCLPGWAPPFCN------TPG 685

Query: 720 PTGETERYKGPSGTNIIIGSIAGAVLVAAIVL 751
             G  +    P  +   +G +   VLVA +VL
Sbjct: 686 HGGSIDSGPMPPES---VGPVVAGVLVAILVL 714


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  343 bits (879), Expect = 5e-94
 Identities = 250/725 (34%), Positives = 344/725 (47%), Gaps = 89/725 (12%)

Query: 12  LLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRV 71
           LLL L P PG      AG L+ G +P  G P  P      +  R  S             
Sbjct: 18  LLLLLWPVPG------AGVLQ-GHIP--GQPVTPHWVLDGQPWRTVS------------- 55

Query: 72  RQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGT-TQHSTGAG 130
            +EP   P + L      + A      L+LE NH LL+  Y+E H+  +G     +    
Sbjct: 56  LEEPVSKPDMGLV----ALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT 111

Query: 131 DHCYYQGKLRGNPHSFAALSTCQGLHGVFS-DGNLTYIVEPQEVAGPWGAPQGPLPHLIY 189
           DHC+YQG++RG P S+  L TC G+ G+ +   N +Y + P    G     +    H I+
Sbjct: 112 DHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGS----KDFSTHEIF 167

Query: 190 RTPLL---PDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVI 246
           R   L       G R+PG        ++ P  P+ R +R+ RR         KY+EL ++
Sbjct: 168 RMEQLLTWKGTCGHRDPG---NKAGMTSLPGGPQSRGRREARRTR-------KYLELYIV 217

Query: 247 NDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLL 306
            DH LF    +++  T      V N  D + +  L+ ++ L  +E W + D+ +V  D  
Sbjct: 218 ADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDAN 276

Query: 307 ETLARLMVYRREGL--PEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGN-- 362
            TL   + +RR GL    P D+  L +GR FQ  + G A V G+C     GGV+   +  
Sbjct: 277 ATLWAFLQWRR-GLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSEL 335

Query: 363 -MGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWL---GCIMED-TGFYLPRKFSRC 417
            +GA A T+A  +G +LG+      S   D  C +      GC+M   TG   PR FS C
Sbjct: 336 PIGA-AATMAHEIGHSLGL------SHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSAC 388

Query: 418 SIDEYNQFLQEGGGSCLFNKPLKLLDPPE--CGNGFVEAGEECDCGSVQECSRAGGNCC- 474
           S  +   F ++GGG+CL N P   L  P   CGNGFVEAGEECDCG  QEC      CC 
Sbjct: 389 SRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDL---CCF 445

Query: 475 -KKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGY 533
              C+L   A C+ G CC RC  +P G  CR+A+ +CD+ E CTG SS CPP+++ LDG 
Sbjct: 446 AHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGS 505

Query: 534 YCDHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQ 590
            C    G C+ G C T ++QCQ LWG  +  A   C++ +N  G   G+CG+   G ++ 
Sbjct: 506 PCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLP 565

Query: 591 CSKQDVLCGFLLCVNISGAPRLGDLVGDISSV--TFYHQGKELDCRGG----HVQLADGS 644
           C+ +D LCG L C    G P L  L   +  V  T +  G+E+ CRG       QL D  
Sbjct: 566 CAGRDALCGKLQCQ--GGKPSL--LAPHMVPVDSTVHLDGQEVTCRGALALPSAQL-DLL 620

Query: 645 DLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDW 704
            L  VE GT CGP M+C   RC   +      C        C  HGVC++   C C P W
Sbjct: 621 GLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRC-----LTACHSHGVCNSNHNCHCAPGW 675

Query: 705 TGKDC 709
               C
Sbjct: 676 APPFC 680


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  340 bits (872), Expect = 3e-93
 Identities = 220/636 (34%), Positives = 308/636 (48%), Gaps = 54/636 (8%)

Query: 99  LDLELNHHLLSSQYVERHFSREGT----TQHSTGAGDHCYYQGKLRGNPHSFAALSTCQG 154
           ++LE N  L++S + E H+ ++GT     ++ T    HCYY G +RG   S  +LSTC G
Sbjct: 81  INLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSG 140

Query: 155 LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSA 214
           L G+    N +Y++EP + A           + ++    L    G    G     P  +A
Sbjct: 141 LRGLIVFENESYVLEPMKSATN--------RYKLFPAKKLKSVRG--SCGSHHNTPNLAA 190

Query: 215 -----PPNRPRLRR-KRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKS 268
                PP++   RR KR+  +        TKYVEL+++ D++ F++  + +         
Sbjct: 191 KNVFPPPSQTWARRHKRETLKA-------TKYVELVIVADNREFQRQGKDLEKVKQRLIE 243

Query: 269 VVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRR-EGLPEPS-DA 326
           + N  D  Y+  LN RIVLV +E W D DK  V  D   +L   + +R+ + LP  S D 
Sbjct: 244 IANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDN 302

Query: 327 THLFSGRTFQSTSSGAAYVGGICSLSHGGGV--NEYGNMGAMAVTLAQTLGQNLGMMWNK 384
             L SG  FQ T+ G A +  +C+    GG+  +   N    AVTLA  LG N GM    
Sbjct: 303 AQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGM---N 359

Query: 385 HRSSAGDCKCPDIWL--GCIME-DTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKP--L 439
           H +    C C       GCIM   TG+  P  FS CS  +    L++G G CLFN P   
Sbjct: 360 HDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVR 419

Query: 440 KLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHDAMCSDGLCCRRCKYE 497
           +     +CGN FVE GEECDCG  +EC      CC    CTL  DA+C+ GLCC  C+ +
Sbjct: 420 ESFGGQKCGNRFVEEGEECDCGEPEECMN---RCCNATTCTLKPDAVCAHGLCCEDCQLK 476

Query: 498 PRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVL 557
           P G +CR++ N CD+ E CTG S  CP N++  DG+ C    G CY G C+T ++QC  L
Sbjct: 477 PAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTL 536

Query: 558 WGHAA--ADRFCYEKLNVEGTERGSCGR-KGSGWVQCSKQDVLCGFLLCVNISGAPRLGD 614
           WG  A  A   C+E++N  G   G+CG+   S + +C  +D  CG + C   +  P +G 
Sbjct: 537 WGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGT 596

Query: 615 LVGDISSVTFYHQGKELDCRGGHVQLADG-SDLSYVEDGTACGPNMLCLDHRCLPASAFN 673
               I +     QG  + CRG HV L D   D   V  GT C    +CL+ +C   S F 
Sbjct: 597 NAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFG 656

Query: 674 FSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDC 709
              C        C   GVC+N   C C+  W    C
Sbjct: 657 VHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFC 687


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  340 bits (872), Expect = 3e-93
 Identities = 220/636 (34%), Positives = 308/636 (48%), Gaps = 54/636 (8%)

Query: 99  LDLELNHHLLSSQYVERHFSREGT----TQHSTGAGDHCYYQGKLRGNPHSFAALSTCQG 154
           ++LE N  L++S + E H+ ++GT     ++ T    HCYY G +RG   S  +LSTC G
Sbjct: 81  INLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSG 140

Query: 155 LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSA 214
           L G+    N +Y++EP + A           + ++    L    G    G     P  +A
Sbjct: 141 LRGLIVFENESYVLEPMKSATN--------RYKLFPAKKLKSVRG--SCGSHHNTPNLAA 190

Query: 215 -----PPNRPRLRR-KRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKS 268
                PP++   RR KR+  +        TKYVEL+++ D++ F++  + +         
Sbjct: 191 KNVFPPPSQTWARRHKRETLKA-------TKYVELVIVADNREFQRQGKDLEKVKQRLIE 243

Query: 269 VVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRR-EGLPEPS-DA 326
           + N  D  Y+  LN RIVLV +E W D DK  V  D   +L   + +R+ + LP  S D 
Sbjct: 244 IANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDN 302

Query: 327 THLFSGRTFQSTSSGAAYVGGICSLSHGGGV--NEYGNMGAMAVTLAQTLGQNLGMMWNK 384
             L SG  FQ T+ G A +  +C+    GG+  +   N    AVTLA  LG N GM    
Sbjct: 303 AQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGM---N 359

Query: 385 HRSSAGDCKCPDIWL--GCIME-DTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKP--L 439
           H +    C C       GCIM   TG+  P  FS CS  +    L++G G CLFN P   
Sbjct: 360 HDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVR 419

Query: 440 KLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHDAMCSDGLCCRRCKYE 497
           +     +CGN FVE GEECDCG  +EC      CC    CTL  DA+C+ GLCC  C+ +
Sbjct: 420 ESFGGQKCGNRFVEEGEECDCGEPEECMN---RCCNATTCTLKPDAVCAHGLCCEDCQLK 476

Query: 498 PRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVL 557
           P G +CR++ N CD+ E CTG S  CP N++  DG+ C    G CY G C+T ++QC  L
Sbjct: 477 PAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTL 536

Query: 558 WGHAA--ADRFCYEKLNVEGTERGSCGR-KGSGWVQCSKQDVLCGFLLCVNISGAPRLGD 614
           WG  A  A   C+E++N  G   G+CG+   S + +C  +D  CG + C   +  P +G 
Sbjct: 537 WGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGT 596

Query: 615 LVGDISSVTFYHQGKELDCRGGHVQLADG-SDLSYVEDGTACGPNMLCLDHRCLPASAFN 673
               I +     QG  + CRG HV L D   D   V  GT C    +CL+ +C   S F 
Sbjct: 597 NAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFG 656

Query: 674 FSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDC 709
              C        C   GVC+N   C C+  W    C
Sbjct: 657 VHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFC 687


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  333 bits (854), Expect = 4e-91
 Identities = 236/733 (32%), Positives = 353/733 (48%), Gaps = 78/733 (10%)

Query: 21  GLGTQGPAGALRWGGLPQLG------GPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQE 74
           G G + P+G LR   L  LG      G   P   + S L    S  E+      TR R+E
Sbjct: 2   GSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHL----SSYEIITPWRLTRERRE 57

Query: 75  PPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGT--TQHSTGAGDH 132
               P  +  QVS+VI A      + LE N  LL   +V   +++EGT  T H     +H
Sbjct: 58  ---APRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPN-IQNH 113

Query: 133 CYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTP 192
           C+Y+G + G  +S  ALS C GL G+    N +Y +EP + +  +        H+IYR  
Sbjct: 114 CHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHF-------EHIIYRMD 166

Query: 193 -LLPDPLGC----REPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVIN 247
            +  +PL C    ++     A   +  PP+  +L R+R+       V  +T+YVEL ++ 
Sbjct: 167 DVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRA------VLPQTRYVELFIVV 220

Query: 248 DHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLE 307
           D + ++ M ++          + N  D +Y   LN RIVLV +E W +G+ I +     +
Sbjct: 221 DKERYDMMGRNQTAVREEMILLANYLDSMYI-MLNIRIVLVGLEIWTNGNLINIVGGAGD 279

Query: 308 TLARLMVYRREGL--PEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGA 365
            L   + +R + L      D+  L   + F  T+ G A+VG +CS SH GG+N +G +  
Sbjct: 280 VLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTA-GMAFVGTVCSRSHAGGINVFGQITV 338

Query: 366 --MAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYN 423
              A  +A  LG NLGM  +  R    DC C      CIM ++G    R FS CS +++ 
Sbjct: 339 ETFASIVAHELGHNLGMNHDDGR----DCSCGA--KSCIM-NSGASGSRNFSSCSAEDFE 391

Query: 424 QFLQEGGGSCLFN--KPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCK--KCTL 479
           +     GG+CL N  KP +    P CGN  V+AGEECDCG+ +EC      CC+   C L
Sbjct: 392 KLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECEL--DPCCEGSTCKL 449

Query: 480 THDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQ 539
              A C+ G CC+ C++ P G  CR   +ECD+ E C G S  C P++   +GY C + +
Sbjct: 450 KSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNK 509

Query: 540 GRCYGGRCKTRDRQCQVLWGH--AAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVL 597
             CY G C+  D QCQV++G    AA + C+ ++N +G   G+CG  G+ + +C+  + L
Sbjct: 510 AYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNAL 569

Query: 598 CGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQL-ADGSDLSYVEDGTACG 656
           CG L C N+   P  G +   I +       +   C G   QL +D  D   V +GT CG
Sbjct: 570 CGKLQCENVQEIPVFGIVPAIIQT-----PSRGTKCWGVDFQLGSDVPDPGMVNEGTKCG 624

Query: 657 PNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLP 716
              +C + +C+ AS  N+        ++ C  HGVC++   C C+  W            
Sbjct: 625 AGKICRNFQCVDASVLNYD----CDVQKKCHGHGVCNSNKNCHCENGW------------ 668

Query: 717 TSPPTGETERYKG 729
            +PP  ET+ Y G
Sbjct: 669 -APPNCETKGYGG 680


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  325 bits (832), Expect = 1e-88
 Identities = 244/700 (34%), Positives = 336/700 (48%), Gaps = 87/700 (12%)

Query: 12  LLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRV 71
           LLL L P PG      AG L+ G +P  G P  P      +  R  S             
Sbjct: 18  LLLLLWPVPG------AGVLQ-GHIP--GQPVTPHWVLDGQPWRTVS------------- 55

Query: 72  RQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGT-TQHSTGAG 130
            +EP   P + L      + A      L+LE NH LL+  Y+E H+  +G     +    
Sbjct: 56  LEEPVSKPDMGLV----ALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT 111

Query: 131 DHCYYQGKLRGNPHSFAALSTCQGLHGVFS-DGNLTYIVEPQEVAGPWGAPQGPLPHLIY 189
           DHC+YQG++RG P S+  L TC G+ G+ +   N +Y + P    G     +    H I+
Sbjct: 112 DHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGS----KDFSTHEIF 167

Query: 190 RTPLL---PDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVI 246
           R   L       G R+PG        ++ P  P+ R +R+ RR         KY+EL ++
Sbjct: 168 RMEQLLTWKGTCGHRDPG---NKAGMTSLPGGPQSRGRREARRTR-------KYLELYIV 217

Query: 247 NDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLL 306
            DH LF    +++  T      V N  D + +  L+ ++ L  +E W + D+ +V  D  
Sbjct: 218 ADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDAN 276

Query: 307 ETLARLMVYRREGL--PEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGN-- 362
            TL   + +RR GL    P D+  L +GR FQ  + G A V G+C     GGV+   +  
Sbjct: 277 ATLWAFLQWRR-GLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSEL 335

Query: 363 -MGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWL---GCIMED-TGFYLPRKFSRC 417
            +GA A T+A  +G +LG+      S   D  C +      GC+M   TG   PR FS C
Sbjct: 336 PIGA-AATMAHEIGHSLGL------SHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSAC 388

Query: 418 SIDEYNQFLQEGGGSCLFNKPLKLLDPPE--CGNGFVEAGEECDCGSVQECSRAGGNCC- 474
           S  +   F ++GGG+CL N P   L  P   CGNGFVEAGEECDCG  QEC      CC 
Sbjct: 389 SRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDL---CCF 445

Query: 475 -KKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGY 533
              C+L   A C+ G CC RC  +P G  CR+A+ +CD+ E CTG SS CPP+++ LDG 
Sbjct: 446 AHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGS 505

Query: 534 YCDHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQ 590
            C    G C+ G C T ++QCQ LWG  +  A   C++ +N  G   G+CG+   G ++ 
Sbjct: 506 PCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLP 565

Query: 591 CSKQDVLCGFLLCVNISGAPRLGDLVGDISSV--TFYHQGKELDCRGG----HVQLADGS 644
           C+ +D LCG L C    G P L  L   +  V  T +  G+E+ CRG       QL D  
Sbjct: 566 CAGRDALCGKLQCQ--GGKPSL--LAPHMVPVDSTVHLDGQEVTCRGALALPSAQL-DLL 620

Query: 645 DLSYVEDGTACGPNMLCLDH---RCLPASAFNFSTCPGSG 681
            L  VE GT CGP M+C  +    C P  A  F   PG G
Sbjct: 621 GLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCDKPGFG 660


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  312 bits (800), Expect = 7e-85
 Identities = 240/727 (33%), Positives = 331/727 (45%), Gaps = 64/727 (8%)

Query: 22  LGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV 81
           LG  G    L    LP +GG    +  E  +  RE    +V +  L   +++      P 
Sbjct: 9   LGLLGAGSPLPSWPLPNIGGTEEQQA-ESEKAPREPLEPQVLQDDLPISLKKVLQTSLPE 67

Query: 82  HLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAG-DHCYYQGKLR 140
            L      +     +  L+L  N  L+  +     +  +GT   S G   ++C YQG++R
Sbjct: 68  PLR---IKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVR 124

Query: 141 GNPHSFAALSTCQGLHG-VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG 199
           G   S+ ++ TC GL G V      +Y +E     GP G  QGP        P++     
Sbjct: 125 GYAGSWVSICTCSGLRGLVVLTPERSYTLEQ----GP-GDLQGP--------PIISRIQD 171

Query: 200 CREPGCLFAVPAQSA-----PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQ 254
              PG   A+  + +     PP  P    +R +RR    V +ETK VEL+++ DH   ++
Sbjct: 172 LHLPGHTCALSWRESVHTQKPPEHPL--GQRHIRRRRDVV-TETKTVELVIVADHSEAQK 228

Query: 255 MRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMV 314
            R    L  N    V  L D  ++  LN R+ LV +E W   D +++  +   TL   + 
Sbjct: 229 YRDFQHLL-NRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH 286

Query: 315 YRREGLPE--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAV--TL 370
           +RR  L    P D+  L +G +F   + G A    ICS    GGVN   +   + V  ++
Sbjct: 287 WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSI 346

Query: 371 AQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDTGFYLPR-KFSRCSIDEYNQFLQ 427
           A  LG +LG+    H      C CP       CIME +  +LP   FS CS     + L 
Sbjct: 347 AHELGHSLGL---DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALL 403

Query: 428 EGGGSCLFNKPLKLLDPPE---CGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHD 482
           +G GSCLF +   L  PP    CGN FVE GE+CDCG + +C      CC    C L   
Sbjct: 404 DGMGSCLFERLPSL--PPMAAFCGNMFVEPGEQCDCGFLDDCVDP---CCDSLTCQLRPG 458

Query: 483 AMC-SDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGR 541
           A C SDG CC+ C+  P G  CR    +CD+ E C GDSSQCPP++   DG  C   Q  
Sbjct: 459 AQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAV 518

Query: 542 CYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLC 598
           C  GRC +  +QCQ LWG  A  A   C +  N  G   GSCGR  SG +V C+ +D +C
Sbjct: 519 CMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAIC 578

Query: 599 GFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLS---YVEDGTAC 655
           G L C      P LG  + D+   T    G EL+C   H+ L  GSD++       GTAC
Sbjct: 579 GQLQCQTGRTQPLLGS-IRDLLWETIDVNGTELNCSWVHLDL--GSDVAQPLLTLPGTAC 635

Query: 656 GPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPL 715
           GP ++C+DHRC          C     R  C  HGVC +   C C+  W   DC+     
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKA 690

Query: 716 PTSPPTG 722
            +S  TG
Sbjct: 691 TSSLTTG 697


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  312 bits (800), Expect = 7e-85
 Identities = 240/727 (33%), Positives = 331/727 (45%), Gaps = 64/727 (8%)

Query: 22  LGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV 81
           LG  G    L    LP +GG    +  E  +  RE    +V +  L   +++      P 
Sbjct: 9   LGLLGAGSPLPSWPLPNIGGTEEQQA-ESEKAPREPLEPQVLQDDLPISLKKVLQTSLPE 67

Query: 82  HLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAG-DHCYYQGKLR 140
            L      +     +  L+L  N  L+  +     +  +GT   S G   ++C YQG++R
Sbjct: 68  PLR---IKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVR 124

Query: 141 GNPHSFAALSTCQGLHG-VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG 199
           G   S+ ++ TC GL G V      +Y +E     GP G  QGP        P++     
Sbjct: 125 GYAGSWVSICTCSGLRGLVVLTPERSYTLEQ----GP-GDLQGP--------PIISRIQD 171

Query: 200 CREPGCLFAVPAQSA-----PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQ 254
              PG   A+  + +     PP  P    +R +RR    V +ETK VEL+++ DH   ++
Sbjct: 172 LHLPGHTCALSWRESVHTQKPPEHPL--GQRHIRRRRDVV-TETKTVELVIVADHSEAQK 228

Query: 255 MRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMV 314
            R    L  N    V  L D  ++  LN R+ LV +E W   D +++  +   TL   + 
Sbjct: 229 YRDFQHLL-NRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH 286

Query: 315 YRREGLPE--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAV--TL 370
           +RR  L    P D+  L +G +F   + G A    ICS    GGVN   +   + V  ++
Sbjct: 287 WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSI 346

Query: 371 AQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDTGFYLPR-KFSRCSIDEYNQFLQ 427
           A  LG +LG+    H      C CP       CIME +  +LP   FS CS     + L 
Sbjct: 347 AHELGHSLGL---DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALL 403

Query: 428 EGGGSCLFNKPLKLLDPPE---CGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHD 482
           +G GSCLF +   L  PP    CGN FVE GE+CDCG + +C      CC    C L   
Sbjct: 404 DGMGSCLFERLPSL--PPMAAFCGNMFVEPGEQCDCGFLDDCVDP---CCDSLTCQLRPG 458

Query: 483 AMC-SDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGR 541
           A C SDG CC+ C+  P G  CR    +CD+ E C GDSSQCPP++   DG  C   Q  
Sbjct: 459 AQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAV 518

Query: 542 CYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLC 598
           C  GRC +  +QCQ LWG  A  A   C +  N  G   GSCGR  SG +V C+ +D +C
Sbjct: 519 CMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAIC 578

Query: 599 GFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLS---YVEDGTAC 655
           G L C      P LG  + D+   T    G EL+C   H+ L  GSD++       GTAC
Sbjct: 579 GQLQCQTGRTQPLLGS-IRDLLWETIDVNGTELNCSWVHLDL--GSDVAQPLLTLPGTAC 635

Query: 656 GPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPL 715
           GP ++C+DHRC          C     R  C  HGVC +   C C+  W   DC+     
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKA 690

Query: 716 PTSPPTG 722
            +S  TG
Sbjct: 691 TSSLTTG 697


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  312 bits (800), Expect = 7e-85
 Identities = 240/727 (33%), Positives = 331/727 (45%), Gaps = 64/727 (8%)

Query: 22  LGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV 81
           LG  G    L    LP +GG    +  E  +  RE    +V +  L   +++      P 
Sbjct: 9   LGLLGAGSPLPSWPLPNIGGTEEQQA-ESEKAPREPLEPQVLQDDLPISLKKVLQTSLPE 67

Query: 82  HLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAG-DHCYYQGKLR 140
            L      +     +  L+L  N  L+  +     +  +GT   S G   ++C YQG++R
Sbjct: 68  PLR---IKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVR 124

Query: 141 GNPHSFAALSTCQGLHG-VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG 199
           G   S+ ++ TC GL G V      +Y +E     GP G  QGP        P++     
Sbjct: 125 GYAGSWVSICTCSGLRGLVVLTPERSYTLEQ----GP-GDLQGP--------PIISRIQD 171

Query: 200 CREPGCLFAVPAQSA-----PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQ 254
              PG   A+  + +     PP  P    +R +RR    V +ETK VEL+++ DH   ++
Sbjct: 172 LHLPGHTCALSWRESVHTQKPPEHPL--GQRHIRRRRDVV-TETKTVELVIVADHSEAQK 228

Query: 255 MRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMV 314
            R    L  N    V  L D  ++  LN R+ LV +E W   D +++  +   TL   + 
Sbjct: 229 YRDFQHLL-NRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH 286

Query: 315 YRREGLPE--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAV--TL 370
           +RR  L    P D+  L +G +F   + G A    ICS    GGVN   +   + V  ++
Sbjct: 287 WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSI 346

Query: 371 AQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDTGFYLPR-KFSRCSIDEYNQFLQ 427
           A  LG +LG+    H      C CP       CIME +  +LP   FS CS     + L 
Sbjct: 347 AHELGHSLGL---DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALL 403

Query: 428 EGGGSCLFNKPLKLLDPPE---CGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHD 482
           +G GSCLF +   L  PP    CGN FVE GE+CDCG + +C      CC    C L   
Sbjct: 404 DGMGSCLFERLPSL--PPMAAFCGNMFVEPGEQCDCGFLDDCVDP---CCDSLTCQLRPG 458

Query: 483 AMC-SDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGR 541
           A C SDG CC+ C+  P G  CR    +CD+ E C GDSSQCPP++   DG  C   Q  
Sbjct: 459 AQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAV 518

Query: 542 CYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLC 598
           C  GRC +  +QCQ LWG  A  A   C +  N  G   GSCGR  SG +V C+ +D +C
Sbjct: 519 CMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAIC 578

Query: 599 GFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLS---YVEDGTAC 655
           G L C      P LG  + D+   T    G EL+C   H+ L  GSD++       GTAC
Sbjct: 579 GQLQCQTGRTQPLLGS-IRDLLWETIDVNGTELNCSWVHLDL--GSDVAQPLLTLPGTAC 635

Query: 656 GPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPL 715
           GP ++C+DHRC          C     R  C  HGVC +   C C+  W   DC+     
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKA 690

Query: 716 PTSPPTG 722
            +S  TG
Sbjct: 691 TSSLTTG 697


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  312 bits (800), Expect = 7e-85
 Identities = 240/727 (33%), Positives = 331/727 (45%), Gaps = 64/727 (8%)

Query: 22  LGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV 81
           LG  G    L    LP +GG    +  E  +  RE    +V +  L   +++      P 
Sbjct: 9   LGLLGAGSPLPSWPLPNIGGTEEQQA-ESEKAPREPLEPQVLQDDLPISLKKVLQTSLPE 67

Query: 82  HLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAG-DHCYYQGKLR 140
            L      +     +  L+L  N  L+  +     +  +GT   S G   ++C YQG++R
Sbjct: 68  PLR---IKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVR 124

Query: 141 GNPHSFAALSTCQGLHG-VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG 199
           G   S+ ++ TC GL G V      +Y +E     GP G  QGP        P++     
Sbjct: 125 GYAGSWVSICTCSGLRGLVVLTPERSYTLEQ----GP-GDLQGP--------PIISRIQD 171

Query: 200 CREPGCLFAVPAQSA-----PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQ 254
              PG   A+  + +     PP  P    +R +RR    V +ETK VEL+++ DH   ++
Sbjct: 172 LHLPGHTCALSWRESVHTQKPPEHPL--GQRHIRRRRDVV-TETKTVELVIVADHSEAQK 228

Query: 255 MRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMV 314
            R    L  N    V  L D  ++  LN R+ LV +E W   D +++  +   TL   + 
Sbjct: 229 YRDFQHLL-NRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH 286

Query: 315 YRREGLPE--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAV--TL 370
           +RR  L    P D+  L +G +F   + G A    ICS    GGVN   +   + V  ++
Sbjct: 287 WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSI 346

Query: 371 AQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDTGFYLPR-KFSRCSIDEYNQFLQ 427
           A  LG +LG+    H      C CP       CIME +  +LP   FS CS     + L 
Sbjct: 347 AHELGHSLGL---DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALL 403

Query: 428 EGGGSCLFNKPLKLLDPPE---CGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHD 482
           +G GSCLF +   L  PP    CGN FVE GE+CDCG + +C      CC    C L   
Sbjct: 404 DGMGSCLFERLPSL--PPMAAFCGNMFVEPGEQCDCGFLDDCVDP---CCDSLTCQLRPG 458

Query: 483 AMC-SDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGR 541
           A C SDG CC+ C+  P G  CR    +CD+ E C GDSSQCPP++   DG  C   Q  
Sbjct: 459 AQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAV 518

Query: 542 CYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLC 598
           C  GRC +  +QCQ LWG  A  A   C +  N  G   GSCGR  SG +V C+ +D +C
Sbjct: 519 CMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAIC 578

Query: 599 GFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLS---YVEDGTAC 655
           G L C      P LG  + D+   T    G EL+C   H+ L  GSD++       GTAC
Sbjct: 579 GQLQCQTGRTQPLLGS-IRDLLWETIDVNGTELNCSWVHLDL--GSDVAQPLLTLPGTAC 635

Query: 656 GPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPL 715
           GP ++C+DHRC          C     R  C  HGVC +   C C+  W   DC+     
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKA 690

Query: 716 PTSPPTG 722
            +S  TG
Sbjct: 691 TSSLTTG 697


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score =  312 bits (800), Expect = 7e-85
 Identities = 240/727 (33%), Positives = 331/727 (45%), Gaps = 64/727 (8%)

Query: 22  LGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV 81
           LG  G    L    LP +GG    +  E  +  RE    +V +  L   +++      P 
Sbjct: 9   LGLLGAGSPLPSWPLPNIGGTEEQQA-ESEKAPREPLEPQVLQDDLPISLKKVLQTSLPE 67

Query: 82  HLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAG-DHCYYQGKLR 140
            L      +     +  L+L  N  L+  +     +  +GT   S G   ++C YQG++R
Sbjct: 68  PLR---IKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVR 124

Query: 141 GNPHSFAALSTCQGLHG-VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG 199
           G   S+ ++ TC GL G V      +Y +E     GP G  QGP        P++     
Sbjct: 125 GYAGSWVSICTCSGLRGLVVLTPERSYTLEQ----GP-GDLQGP--------PIISRIQD 171

Query: 200 CREPGCLFAVPAQSA-----PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQ 254
              PG   A+  + +     PP  P    +R +RR    V +ETK VEL+++ DH   ++
Sbjct: 172 LHLPGHTCALSWRESVHTQKPPEHPL--GQRHIRRRRDVV-TETKTVELVIVADHSEAQK 228

Query: 255 MRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMV 314
            R    L  N    V  L D  ++  LN R+ LV +E W   D +++  +   TL   + 
Sbjct: 229 YRDFQHLL-NRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH 286

Query: 315 YRREGLPE--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAV--TL 370
           +RR  L    P D+  L +G +F   + G A    ICS    GGVN   +   + V  ++
Sbjct: 287 WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSI 346

Query: 371 AQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDTGFYLPR-KFSRCSIDEYNQFLQ 427
           A  LG +LG+    H      C CP       CIME +  +LP   FS CS     + L 
Sbjct: 347 AHELGHSLGL---DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALL 403

Query: 428 EGGGSCLFNKPLKLLDPPE---CGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHD 482
           +G GSCLF +   L  PP    CGN FVE GE+CDCG + +C      CC    C L   
Sbjct: 404 DGMGSCLFERLPSL--PPMAAFCGNMFVEPGEQCDCGFLDDCVDP---CCDSLTCQLRPG 458

Query: 483 AMC-SDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGR 541
           A C SDG CC+ C+  P G  CR    +CD+ E C GDSSQCPP++   DG  C   Q  
Sbjct: 459 AQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAV 518

Query: 542 CYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLC 598
           C  GRC +  +QCQ LWG  A  A   C +  N  G   GSCGR  SG +V C+ +D +C
Sbjct: 519 CMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAIC 578

Query: 599 GFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLS---YVEDGTAC 655
           G L C      P LG  + D+   T    G EL+C   H+ L  GSD++       GTAC
Sbjct: 579 GQLQCQTGRTQPLLGS-IRDLLWETIDVNGTELNCSWVHLDL--GSDVAQPLLTLPGTAC 635

Query: 656 GPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPL 715
           GP ++C+DHRC          C     R  C  HGVC +   C C+  W   DC+     
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKA 690

Query: 716 PTSPPTG 722
            +S  TG
Sbjct: 691 TSSLTTG 697


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  312 bits (800), Expect = 7e-85
 Identities = 240/727 (33%), Positives = 331/727 (45%), Gaps = 64/727 (8%)

Query: 22  LGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPV 81
           LG  G    L    LP +GG    +  E  +  RE    +V +  L   +++      P 
Sbjct: 9   LGLLGAGSPLPSWPLPNIGGTEEQQA-ESEKAPREPLEPQVLQDDLPISLKKVLQTSLPE 67

Query: 82  HLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAG-DHCYYQGKLR 140
            L      +     +  L+L  N  L+  +     +  +GT   S G   ++C YQG++R
Sbjct: 68  PLR---IKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVR 124

Query: 141 GNPHSFAALSTCQGLHG-VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG 199
           G   S+ ++ TC GL G V      +Y +E     GP G  QGP        P++     
Sbjct: 125 GYAGSWVSICTCSGLRGLVVLTPERSYTLEQ----GP-GDLQGP--------PIISRIQD 171

Query: 200 CREPGCLFAVPAQSA-----PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQ 254
              PG   A+  + +     PP  P    +R +RR    V +ETK VEL+++ DH   ++
Sbjct: 172 LHLPGHTCALSWRESVHTQKPPEHPL--GQRHIRRRRDVV-TETKTVELVIVADHSEAQK 228

Query: 255 MRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMV 314
            R    L  N    V  L D  ++  LN R+ LV +E W   D +++  +   TL   + 
Sbjct: 229 YRDFQHLL-NRTLEVALLLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLH 286

Query: 315 YRREGLPE--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAV--TL 370
           +RR  L    P D+  L +G +F   + G A    ICS    GGVN   +   + V  ++
Sbjct: 287 WRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSI 346

Query: 371 AQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDTGFYLPR-KFSRCSIDEYNQFLQ 427
           A  LG +LG+    H      C CP       CIME +  +LP   FS CS     + L 
Sbjct: 347 AHELGHSLGL---DHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALL 403

Query: 428 EGGGSCLFNKPLKLLDPPE---CGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHD 482
           +G GSCLF +   L  PP    CGN FVE GE+CDCG + +C      CC    C L   
Sbjct: 404 DGMGSCLFERLPSL--PPMAAFCGNMFVEPGEQCDCGFLDDCVDP---CCDSLTCQLRPG 458

Query: 483 AMC-SDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGR 541
           A C SDG CC+ C+  P G  CR    +CD+ E C GDSSQCPP++   DG  C   Q  
Sbjct: 459 AQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAV 518

Query: 542 CYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQCSKQDVLC 598
           C  GRC +  +QCQ LWG  A  A   C +  N  G   GSCGR  SG +V C+ +D +C
Sbjct: 519 CMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAIC 578

Query: 599 GFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLS---YVEDGTAC 655
           G L C      P LG  + D+   T    G EL+C   H+ L  GSD++       GTAC
Sbjct: 579 GQLQCQTGRTQPLLGS-IRDLLWETIDVNGTELNCSWVHLDL--GSDVAQPLLTLPGTAC 635

Query: 656 GPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPL 715
           GP ++C+DHRC          C     R  C  HGVC +   C C+  W   DC+     
Sbjct: 636 GPGLVCIDHRCQRVDLLGAQEC-----RSKCHGHGVCDSNRHCYCEEGWAPPDCTTQLKA 690

Query: 716 PTSPPTG 722
            +S  TG
Sbjct: 691 TSSLTTG 697


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  295 bits (754), Expect = 1e-79
 Identities = 193/628 (30%), Positives = 293/628 (46%), Gaps = 58/628 (9%)

Query: 99  LDLELNHHLLSSQYVERHFSREGTT-QHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHG 157
           L L+ N +LL+  Y E +++  G     S    D CYYQG +     S A++STC+GL G
Sbjct: 70  LYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTCRGLRG 129

Query: 158 VFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLG----CREPGCLFAVPAQS 213
            FS G+  Y +EP       G       H +++    PD       C   G L+A   Q 
Sbjct: 130 YFSQGDQRYFIEPLSPIHRDGQE-----HALFKYN--PDEKNYDSTCGMDGVLWAHDLQQ 182

Query: 214 APPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLA 273
                  L   + V+     V    KY+E  ++ D+  F++  ++          + N  
Sbjct: 183 ----NIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238

Query: 274 DVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPS--DATHLFS 331
           +++YK+ LNT + LV ME W D DKI++  +   TL     +R   L      D   L +
Sbjct: 239 NMLYKK-LNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLIT 297

Query: 332 GRTFQSTSSGAAYVGGICSLSHGGGVNEYG-NMGAMAVTLAQTLGQNLGMMWNKHRSSAG 390
                 T+ G A++  +CS    G V ++  N+  +A T+A  +G N GM  + +     
Sbjct: 298 ATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDY----- 352

Query: 391 DCKCPDIWLGCIMEDT-GFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLK--LLDPPEC 447
            CKCP     C+M+    FY+P  FS CS   Y++F ++   +CLFN PL   ++  P C
Sbjct: 353 SCKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPIC 410

Query: 448 GNGFVEAGEECDCGSVQECSRAGGNCC--KKCTLTHDAMCSDGLCCRRCKYEPRGVSCRE 505
           GN  VE GE+CDCG+ +EC+     CC  K C +     C+ G CC +C+++  G+ CR 
Sbjct: 411 GNQLVEMGEDCDCGTSEECTNI---CCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRP 467

Query: 506 AVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHA--AA 563
           A +ECD+ E C G S  CP +  +++G+ C H +G C  G C T   QC  LWG     A
Sbjct: 468 AKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVA 527

Query: 564 DRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNIS-GAPRLGDLVGDISSV 622
           D+ CY + N  G++ G C R     + C   D +CG L C   S   P  G +V  ++  
Sbjct: 528 DKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCK 586

Query: 623 TFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLP-ASAFNFSTCPGSG 681
           TF  +                 ++  V +GT CG N +C++  C+    A+  + C    
Sbjct: 587 TFDPED-------------TSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSK- 632

Query: 682 ERRICSHHGVCSNEGKCICQPDWTGKDC 709
               C  H VC +E +C C+  W   DC
Sbjct: 633 ----CKGHAVCDHELQCQCEEGWIPPDC 656


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  293 bits (751), Expect = 3e-79
 Identities = 209/654 (31%), Positives = 290/654 (44%), Gaps = 66/654 (10%)

Query: 70  RVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGA 129
           RVR+  P    +H  +VS+V+ A   NFTL L  N  LL S Y E + +  G+       
Sbjct: 41  RVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPR 100

Query: 130 G-DHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLI 188
           G DHC+YQG + G P S A+LSTC GL G F  G+  +++EP +  G  G       H +
Sbjct: 101 GQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGR------HAV 154

Query: 189 YRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVIND 248
           Y+   L    G     C  +  +  +    PR     + R G      ET+YVEL V+ D
Sbjct: 155 YQAEHLLQTAGT----CGVSDDSLGSLLG-PRTAAVFRPRPGDSLPSRETRYVELYVVVD 209

Query: 249 HQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLET 308
           +  F QM  S     +    VVN  D +Y ++LN R+VLV +E W   D+  V  D   T
Sbjct: 210 NAEF-QMLGSEAAVRHRVLEVVNHVDKLY-QKLNFRVVLVGLEIWNSQDRFHVSPDPSVT 267

Query: 309 LARLMVY--RREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYG-NMGA 365
           L  L+ +  R+       D   L +G  F  T+ G A V  +CS S G    ++  N   
Sbjct: 268 LENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKNPVG 327

Query: 366 MAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLG--CIMEDT-GFYLPRKFSRCSIDEY 422
           +A T+A  +G NLGM    H  +   C+C + +    CIM  + G   PR FS CS    
Sbjct: 328 VACTMAHEMGHNLGM---DHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYL 384

Query: 423 NQFLQEGGGSCLFNKP--LKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKK--CT 478
             FL+     CL N P    L+  P CGN FVE GE+CDCG  ++C      CC    C 
Sbjct: 385 ESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRN---RCCNSTTCQ 441

Query: 479 LTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHE 538
           L   A C+ G CC+ CK +P G  CR   + CD+ E C G   +CP +  + +G  C   
Sbjct: 442 LAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPC--S 499

Query: 539 QGRCYGGRCKTRDRQCQVLWGHA--AADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDV 596
            G CY G C T  +QCQ  WG    AA+  C+    + G +         G +QC     
Sbjct: 500 GGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKGGQQ 559

Query: 597 LCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACG 656
             G  +C+                 V   H           +   DG+    V +GT CG
Sbjct: 560 PLGRAICI-----------------VDVCHA----------LTTEDGTAYEPVPEGTRCG 592

Query: 657 PNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCS 710
           P  +C   RC     +  S C        C +HGVC+++ +C C   W    C+
Sbjct: 593 PEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCA 641



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 19/79 (24%), Positives = 32/79 (40%), Gaps = 1/79 (1%)

Query: 15  SLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQE 74
           ++ P   +G   P        +P  GG  AP    P  LV  +  G+  +    +   + 
Sbjct: 689 NVAPKTTMGRSNPLFHQAASRVPAKGGAPAPS-RGPQELVPTTHPGQPARHPASSVALKR 747

Query: 75  PPGGPPVHLAQVSFVIPAF 93
           PP  PPV ++   F +P +
Sbjct: 748 PPPAPPVTVSSPPFPVPVY 766


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  266 bits (681), Expect = 4e-71
 Identities = 185/631 (29%), Positives = 289/631 (45%), Gaps = 50/631 (7%)

Query: 85  QVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGT--TQHSTGAGDHCYYQGKLRGN 142
           ++ + I        L L  +   L S Y E  +S +G   T+H     DHC+YQG +   
Sbjct: 58  ELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQ-IMDHCFYQGSIVHE 116

Query: 143 PHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCRE 202
             S A++STC GL G F   +  Y++EP + +           HL+++  L   P G   
Sbjct: 117 YDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEG-------EHLVFKYNLRV-PYGANY 168

Query: 203 PGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLT 262
             C      +   P         +++  H     + KYVEL ++ D  ++ +        
Sbjct: 169 -SCTELNFTRKTVPGDNESEEDSKIKGIH-----DEKYVELFIVADDTVYRRNGHPHNKL 222

Query: 263 SNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPE 322
            N    +VN  ++IYK  LN  + LV +E W   DKI++  ++  TL R   ++ + L  
Sbjct: 223 RNRIWGMVNFVNMIYKT-LNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKT 281

Query: 323 PSDATH--LFSGRTFQSTSSGAAYVGGICSLSHGGGVNE--YGNMGAMAVTLAQTLGQNL 378
             D  H  L SG+   S   G +Y GG+C   +   + +    +   +A  +A  LG NL
Sbjct: 282 RKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNL 341

Query: 379 GMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKP 438
           GM  ++       C CP     C+M+  G     KFS+CS ++Y+Q+L++   +C+ N P
Sbjct: 342 GMQHDEF-----PCTCPSG--KCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIP 394

Query: 439 L--KLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHDAMCSDGLCCRRC 494
                 D   CGN  ++ GEECDCG  QEC+     CC    C L     C++G CC  C
Sbjct: 395 FPYNFHDFQFCGNKKLDEGEECDCGPAQECTNP---CCDAHTCVLKPGFTCAEGECCESC 451

Query: 495 KYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQC 554
           + +  G  CR A +ECD  E CTG S  CP +  +++G+ C + +G C+ G+C TR+ QC
Sbjct: 452 QIKKAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQC 511

Query: 555 QVLWGHAAADR--FCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRL 612
             L+   A +    CY K+N +G + G C  K + ++ C ++DV CG + C        L
Sbjct: 512 SELFDDEAIESHDICY-KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCT----GGEL 566

Query: 613 GDLVGDISSVTFYHQGKELDCRGGHVQL-ADGSDLSYVEDGTACGPNMLCLDHRCLPASA 671
             L+G+  +       K    +   + L  D +D+  V  GT CG  M+C +  CL    
Sbjct: 567 SSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEK 626

Query: 672 FNFST-CPGSGERRICSHHGVCSNEGKCICQ 701
              ST CP          HG+     +C C+
Sbjct: 627 VYISTNCPSQCNENPVDGHGL-----QCHCE 652


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score =  264 bits (675), Expect = 2e-70
 Identities = 193/625 (30%), Positives = 281/625 (44%), Gaps = 52/625 (8%)

Query: 131 DHCYYQGKLRGNPHSFAALSTC-QGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIY 189
           D CYY G + G P S    S C  G  GV     LTY +EP   +  +        HL+Y
Sbjct: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATF-------EHLVY 159

Query: 190 RTPLLPDPLGCREPGCLFA-VPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVIND 248
           +             G     V  Q                 G    H+   ++EL+V+ +
Sbjct: 160 KVNSNETQFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAW--FLELVVVVN 217

Query: 249 HQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLET 308
           H  F   + ++         VVN+ D +Y +QL T I+L+ +E W  G+   +   + + 
Sbjct: 218 HDFFIYSQSNISKVQEDVFLVVNIVDSMY-QQLGTYIILIGIEIWNQGNVFPMTS-IEQV 275

Query: 309 LARLMVYRREGLPE-PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEY--GNMGA 365
           L     +++  L +   DA H+F   +  S   G AYV GIC      GV+ +       
Sbjct: 276 LNDFSQWKQISLSQLQHDAAHMFIKNSLISIL-GLAYVAGICRPPIDCGVDNFQGDTWSL 334

Query: 366 MAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLP-RKFSRCSIDEYNQ 424
            A T+A  LG  LGM  ++     G+        GCIM    F +P  KF+ CS   Y  
Sbjct: 335 FANTVAHELGHTLGMQHDEEFCFCGE-------RGCIMNT--FRVPAEKFTNCS---YAD 382

Query: 425 FLQE--GGGSCLFNKPL--KLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLT 480
           F++     GSCL N P   ++     CGNG VE  E+CDCGSVQ+C +    C   CTL 
Sbjct: 383 FMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQ-DACCLLNCTLR 441

Query: 481 HDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQG 540
             A C+ GLCC+ CK+ P G  CR+ VNECD+ E C G S QCP + +  DG  C  +  
Sbjct: 442 PGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSA 500

Query: 541 RCYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLC 598
            CY  RC   D+ C+ ++G  A  A + CY+++N +G   G CG  G+ +++C   DV C
Sbjct: 501 YCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFC 560

Query: 599 GFLLCVNISGAPRLGDLVGDISSVTFYHQG-KELDCRGGHVQL-ADGSDLSYVEDGTACG 656
           G + C N+   P L D        T  H     + C G    L  + SD+  V+DGT CG
Sbjct: 561 GRVQCENVRDIPLLQD------HFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCG 614

Query: 657 PNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLP 716
           P  +C+  +C+  S  +    P       C+  G+C+N+  C C   W+   C  H    
Sbjct: 615 PGKICIHKKCVSLSVLSHVCLP-----ETCNMKGICNNKHHCHCGYGWSPPYCQ-HRGYG 668

Query: 717 TSPPTGETERYKGPSGTNIIIGSIA 741
            S  +G     +G     I+I S++
Sbjct: 669 GSIDSGPASAKRGVFLPLIVIPSLS 693


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score =  261 bits (667), Expect = 2e-69
 Identities = 210/689 (30%), Positives = 318/689 (46%), Gaps = 91/689 (13%)

Query: 96  NFTLDLELNHHLL----SSQYVERHFSREGTTQHSTGAGDH------CYYQGKLRGNPHS 145
           ++ L L+   H+L        + RH      T+H     DH      C Y G ++ +  S
Sbjct: 63  SYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDS 122

Query: 146 FAALSTCQG-LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPG 204
            A +STC G L GVF+     Y +EP + +  +        H++Y   L  +  G +  G
Sbjct: 123 KATISTCMGGLRGVFNIDAKHYQIEPLKASPSF-------EHVVYL--LKKEQFGNQVCG 173

Query: 205 CLF-AVPAQSAP-PNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLT 262
                +  Q AP  N+ RLR         P  +   KY+ELI++ D   +  +  ++   
Sbjct: 174 LSDDEIEWQMAPYENKARLR-------DFPGSYKHPKYLELILLFDQSRYRFVNNNLSQV 226

Query: 263 SNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQV-QDDLLETLARLMVYRREGLP 321
            + A  +  + D  Y + +  RI L A+E W D +KI+V   +L E L R ++Y++  L 
Sbjct: 227 IHDAILLTGIMDT-YFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLN 285

Query: 322 E--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEY--GNMGAMAVTLAQTLGQN 377
               SD  HL+  R +    + +   G +CSL + G V+     N+ A A   A  LG  
Sbjct: 286 ARLSSDWAHLYLQRKYNDALAWS--FGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHA 343

Query: 378 LGMMWNKHRSSAGDCKCPDIWLGCIMED--TGFYLPRKFSRCSIDEYNQFLQEGGGSCLF 435
           +GM  ++       C+C    L CIM    TGF      S CS   + + +  G  +CL 
Sbjct: 344 VGMSHDEQY-----CQCRGR-LNCIMGSGRTGF------SNCSYISFFKHISSGA-TCLN 390

Query: 436 NKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKK-CTLTHDAMCSDGLCCRRC 494
           N P        CGN  VE  EECDCGS +EC +    CC+  C L   A CS GLCC  C
Sbjct: 391 NIPGLGYVLKRCGNKIVEDNEECDCGSTEECQK--DRCCQSNCKLQPGANCSIGLCCHDC 448

Query: 495 KYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQC 554
           ++ P G  CR+  NECD+AE C G+SS CP +++K DG  C +E GRC+   C++R  QC
Sbjct: 449 RFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCKYE-GRCFRKGCRSRYMQC 507

Query: 555 QVLWGHAA--ADRFCYEKLNVEGTERGSCGRKG-SGWVQCSKQDVLCGFLLCVNISGAPR 611
           Q ++G  A  A   CY+ +N+ G + G+C   G   + +C   + +CG L C+N+   P 
Sbjct: 508 QSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIP- 566

Query: 612 LGDLVGDISSVTFYHQGKELDCRGGHVQLA----DGSDLSYVEDGTACGPNMLCLDHRCL 667
             DL    + ++ + Q + L C G    L+       DL  + DGT+CG   +C    C+
Sbjct: 567 --DLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCV 624

Query: 668 PASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERY 727
            +S   F   P       C+  GVC+N   C C   W             +PP  E   Y
Sbjct: 625 NSSVLQFDCLPEK-----CNTRGVCNNRKNCHCMYGW-------------APPFCEEVGY 666

Query: 728 -----KGPSGTNIIIGSIAGAVLVAAIVL 751
                 GP G  ++ G+I  ++ V +I++
Sbjct: 667 GGSIDSGPPG--LLRGAIPSSIWVVSIIM 693


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  259 bits (662), Expect = 7e-69
 Identities = 194/622 (31%), Positives = 281/622 (45%), Gaps = 62/622 (9%)

Query: 106 HLLSSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQG-LHGVFSDGNL 164
           HL    Y E+H       Q      D CYY G + G P S  ALSTC G   G+    +L
Sbjct: 136 HLPVFTYTEQH----ALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDL 191

Query: 165 TYIVEPQEVAGPWGAPQGPLPHLIYR-----TPLLPDPLGCREPGCLFAVPAQSAPPNRP 219
            Y ++P  V+  +        HL+Y+     T   P   G  E      +  Q +     
Sbjct: 192 VYEIKPISVSATF-------EHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSY---- 240

Query: 220 RLRRKRQVRRGHPTVHSETKYVELIVINDH--QLFEQMRQSVVLTSNFAKSVVNLADVIY 277
               K+    G  T     ++VEL+V+ D+   LF Q   + V    F  +VVN+ D  Y
Sbjct: 241 NFTLKQSSFVGWWT---HQRFVELVVVVDNIRYLFSQSNATTVQHEVF--NVVNIVDSFY 295

Query: 278 KEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPE--PSDATHLFSGRTF 335
              L   ++L  ++ W   + +    DL   L    +++   L      D  HLF   T 
Sbjct: 296 -HPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDT- 353

Query: 336 QSTSSGAAYVGGICSLSHGGGVN--EYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCK 393
           Q    G AYV GIC      GV+  E   +   A+TL   LG NLGM  +        C 
Sbjct: 354 QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQW-----CV 408

Query: 394 CPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPL--KLLDPPECGNGF 451
           C   W  CIM      +  KFS CS  +Y       G  C+   P    +     CGN  
Sbjct: 409 CELQW--CIMHAYR-KVTTKFSNCSYAQYWDSTISSG-LCIQPPPYPGNIFRLKYCGNLV 464

Query: 452 VEAGEECDCGSVQECSRAGGNCCK-KCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNEC 510
           VE GEECDCG++++C++    CC   CTL   A C+ G+CC+ CK+ P G  CR+ V EC
Sbjct: 465 VEEGEECDCGTIRQCAK--DPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGEC 522

Query: 511 DIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRFCY 568
           D+ E C G S QCP +++  DG  C +    CY   C   D QC+ ++G  A  A + CY
Sbjct: 523 DLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCY 581

Query: 569 EKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQG 628
           +++N +G   G CG  G+ +V+C   D++CG + C N+   P L     + S+V  +H  
Sbjct: 582 QEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNL----IEHSTVQQFHL- 636

Query: 629 KELDCRGGHVQLADG-SDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICS 687
            +  C G    L     D+  V+DGT CGP  +C+  +C  AS  + S    + + + C+
Sbjct: 637 NDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKC--ASMVHLSQ---ACQPKTCN 691

Query: 688 HHGVCSNEGKCICQPDWTGKDC 709
             G+C+N+  C C  +W    C
Sbjct: 692 MRGICNNKQHCHCNHEWAPPYC 713


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  253 bits (646), Expect = 5e-67
 Identities = 186/706 (26%), Positives = 314/706 (44%), Gaps = 69/706 (9%)

Query: 37  PQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSN 96
           PQ   P  P+V  P R+   + G               PPG        +S+++P     
Sbjct: 25  PQYHSP--PDVVIPVRITGTTRG-------------MTPPGW-------LSYILPFGGQK 62

Query: 97  FTLDLELNHHLLSSQYVERHFSREGTT-QHSTGAGDHCYYQGKLRGNPHSFAALSTC-QG 154
             + +++   L S       ++ +G   +      ++CYY G + G+P S  +LSTC  G
Sbjct: 63  HIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGG 122

Query: 155 LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSA 214
             G+    +  Y ++P   +  +        HL+Y+             G  F     + 
Sbjct: 123 FQGILQINDFAYEIKPLAFSTTF-------EHLVYKMDSEEKQFSTMRSG--FMQNEITC 173

Query: 215 PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLAD 274
                 +    Q +  +       + VE++V+ D+ L+ +  ++          +VN+ D
Sbjct: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233

Query: 275 VIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPE--PSDATHLFSG 332
            I  + +  +++L  +E W + + I V DD+ +++     ++ E +      D +HLF+ 
Sbjct: 234 SIL-DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291

Query: 333 RTFQSTSSGAAYVGGICSLSHGGGVNEYGN--MGAMAVTLAQTLGQNLGMMWNKHRSSAG 390
              +  S   A+  G+C+      +  + N  +G  ++ +A  LG NLGM    H     
Sbjct: 292 LGLRGLSGIGAF-RGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM---NHDEDTC 347

Query: 391 DCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLK-LLDPPECGN 449
            C  P     CIM + G     KFS CS  ++ ++  E     L     K + +   CGN
Sbjct: 348 RCSQPR----CIMHE-GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGN 402

Query: 450 GFVEAGEECDCGSVQECSRAGGNCC-KKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVN 508
           G VE GEECDCG ++ C++    CC   CTLT  + C+ GLCC+ CK+ P G  CR+ VN
Sbjct: 403 GVVEEGEECDCGPLKHCAK--DPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVN 460

Query: 509 ECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRF 566
           ECD+ E C G S +CP + +  DG  C  E+G CY   C  R+ QC+ ++G  A  A   
Sbjct: 461 ECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASET 519

Query: 567 CYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYH 626
           CY++LN  G   G CG K + +++C+  DV CG + C N++  P + D      +   + 
Sbjct: 520 CYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSD-----HTTVHWA 574

Query: 627 QGKELDCRGGHVQLA-DGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRI 685
           +  ++ C      L   G D+  V+DGT CG + +C+   C+  +  N +  P       
Sbjct: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPA-----F 629

Query: 686 CSHHGVCSNEGKCICQPDWTGKDCSIH---NPLPTSPPTGETERYK 728
           C+  G+C+N+  C C   W   +C I      + + PP    ++ K
Sbjct: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKK 675


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  253 bits (646), Expect = 5e-67
 Identities = 186/706 (26%), Positives = 314/706 (44%), Gaps = 69/706 (9%)

Query: 37  PQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSN 96
           PQ   P  P+V  P R+   + G               PPG        +S+++P     
Sbjct: 25  PQYHSP--PDVVIPVRITGTTRG-------------MTPPGW-------LSYILPFGGQK 62

Query: 97  FTLDLELNHHLLSSQYVERHFSREGTT-QHSTGAGDHCYYQGKLRGNPHSFAALSTC-QG 154
             + +++   L S       ++ +G   +      ++CYY G + G+P S  +LSTC  G
Sbjct: 63  HIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGG 122

Query: 155 LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSA 214
             G+    +  Y ++P   +  +        HL+Y+             G  F     + 
Sbjct: 123 FQGILQINDFAYEIKPLAFSTTF-------EHLVYKMDSEEKQFSTMRSG--FMQNEITC 173

Query: 215 PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLAD 274
                 +    Q +  +       + VE++V+ D+ L+ +  ++          +VN+ D
Sbjct: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233

Query: 275 VIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPE--PSDATHLFSG 332
            I  + +  +++L  +E W + + I V DD+ +++     ++ E +      D +HLF+ 
Sbjct: 234 SIL-DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291

Query: 333 RTFQSTSSGAAYVGGICSLSHGGGVNEYGN--MGAMAVTLAQTLGQNLGMMWNKHRSSAG 390
              +  S   A+  G+C+      +  + N  +G  ++ +A  LG NLGM    H     
Sbjct: 292 LGLRGLSGIGAF-RGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM---NHDEDTC 347

Query: 391 DCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLK-LLDPPECGN 449
            C  P     CIM + G     KFS CS  ++ ++  E     L     K + +   CGN
Sbjct: 348 RCSQPR----CIMHE-GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGN 402

Query: 450 GFVEAGEECDCGSVQECSRAGGNCC-KKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVN 508
           G VE GEECDCG ++ C++    CC   CTLT  + C+ GLCC+ CK+ P G  CR+ VN
Sbjct: 403 GVVEEGEECDCGPLKHCAK--DPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVN 460

Query: 509 ECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRF 566
           ECD+ E C G S +CP + +  DG  C  E+G CY   C  R+ QC+ ++G  A  A   
Sbjct: 461 ECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASET 519

Query: 567 CYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYH 626
           CY++LN  G   G CG K + +++C+  DV CG + C N++  P + D      +   + 
Sbjct: 520 CYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSD-----HTTVHWA 574

Query: 627 QGKELDCRGGHVQLA-DGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRI 685
           +  ++ C      L   G D+  V+DGT CG + +C+   C+  +  N +  P       
Sbjct: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPA-----F 629

Query: 686 CSHHGVCSNEGKCICQPDWTGKDCSIH---NPLPTSPPTGETERYK 728
           C+  G+C+N+  C C   W   +C I      + + PP    ++ K
Sbjct: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKK 675


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  253 bits (646), Expect = 5e-67
 Identities = 186/706 (26%), Positives = 314/706 (44%), Gaps = 69/706 (9%)

Query: 37  PQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSN 96
           PQ   P  P+V  P R+   + G               PPG        +S+++P     
Sbjct: 25  PQYHSP--PDVVIPVRITGTTRG-------------MTPPGW-------LSYILPFGGQK 62

Query: 97  FTLDLELNHHLLSSQYVERHFSREGTT-QHSTGAGDHCYYQGKLRGNPHSFAALSTC-QG 154
             + +++   L S       ++ +G   +      ++CYY G + G+P S  +LSTC  G
Sbjct: 63  HIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGG 122

Query: 155 LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSA 214
             G+    +  Y ++P   +  +        HL+Y+             G  F     + 
Sbjct: 123 FQGILQINDFAYEIKPLAFSTTF-------EHLVYKMDSEEKQFSTMRSG--FMQNEITC 173

Query: 215 PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLAD 274
                 +    Q +  +       + VE++V+ D+ L+ +  ++          +VN+ D
Sbjct: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233

Query: 275 VIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPE--PSDATHLFSG 332
            I  + +  +++L  +E W + + I V DD+ +++     ++ E +      D +HLF+ 
Sbjct: 234 SIL-DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291

Query: 333 RTFQSTSSGAAYVGGICSLSHGGGVNEYGN--MGAMAVTLAQTLGQNLGMMWNKHRSSAG 390
              +  S   A+  G+C+      +  + N  +G  ++ +A  LG NLGM    H     
Sbjct: 292 LGLRGLSGIGAF-RGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM---NHDEDTC 347

Query: 391 DCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLK-LLDPPECGN 449
            C  P     CIM + G     KFS CS  ++ ++  E     L     K + +   CGN
Sbjct: 348 RCSQPR----CIMHE-GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGN 402

Query: 450 GFVEAGEECDCGSVQECSRAGGNCC-KKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVN 508
           G VE GEECDCG ++ C++    CC   CTLT  + C+ GLCC+ CK+ P G  CR+ VN
Sbjct: 403 GVVEEGEECDCGPLKHCAK--DPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVN 460

Query: 509 ECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRF 566
           ECD+ E C G S +CP + +  DG  C  E+G CY   C  R+ QC+ ++G  A  A   
Sbjct: 461 ECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASET 519

Query: 567 CYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYH 626
           CY++LN  G   G CG K + +++C+  DV CG + C N++  P + D      +   + 
Sbjct: 520 CYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSD-----HTTVHWA 574

Query: 627 QGKELDCRGGHVQLA-DGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRI 685
           +  ++ C      L   G D+  V+DGT CG + +C+   C+  +  N +  P       
Sbjct: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPA-----F 629

Query: 686 CSHHGVCSNEGKCICQPDWTGKDCSIH---NPLPTSPPTGETERYK 728
           C+  G+C+N+  C C   W   +C I      + + PP    ++ K
Sbjct: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKK 675


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  253 bits (646), Expect = 5e-67
 Identities = 186/706 (26%), Positives = 314/706 (44%), Gaps = 69/706 (9%)

Query: 37  PQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSN 96
           PQ   P  P+V  P R+   + G               PPG        +S+++P     
Sbjct: 25  PQYHSP--PDVVIPVRITGTTRG-------------MTPPGW-------LSYILPFGGQK 62

Query: 97  FTLDLELNHHLLSSQYVERHFSREGTT-QHSTGAGDHCYYQGKLRGNPHSFAALSTC-QG 154
             + +++   L S       ++ +G   +      ++CYY G + G+P S  +LSTC  G
Sbjct: 63  HIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGG 122

Query: 155 LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSA 214
             G+    +  Y ++P   +  +        HL+Y+             G  F     + 
Sbjct: 123 FQGILQINDFAYEIKPLAFSTTF-------EHLVYKMDSEEKQFSTMRSG--FMQNEITC 173

Query: 215 PPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLAD 274
                 +    Q +  +       + VE++V+ D+ L+ +  ++          +VN+ D
Sbjct: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233

Query: 275 VIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPE--PSDATHLFSG 332
            I  + +  +++L  +E W + + I V DD+ +++     ++ E +      D +HLF+ 
Sbjct: 234 SIL-DVIGVKVLLFGLEIWTNKNLIVV-DDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291

Query: 333 RTFQSTSSGAAYVGGICSLSHGGGVNEYGN--MGAMAVTLAQTLGQNLGMMWNKHRSSAG 390
              +  S   A+  G+C+      +  + N  +G  ++ +A  LG NLGM    H     
Sbjct: 292 LGLRGLSGIGAF-RGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGM---NHDEDTC 347

Query: 391 DCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLK-LLDPPECGN 449
            C  P     CIM + G     KFS CS  ++ ++  E     L     K + +   CGN
Sbjct: 348 RCSQPR----CIMHE-GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGN 402

Query: 450 GFVEAGEECDCGSVQECSRAGGNCC-KKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVN 508
           G VE GEECDCG ++ C++    CC   CTLT  + C+ GLCC+ CK+ P G  CR+ VN
Sbjct: 403 GVVEEGEECDCGPLKHCAK--DPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVN 460

Query: 509 ECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRF 566
           ECD+ E C G S +CP + +  DG  C  E+G CY   C  R+ QC+ ++G  A  A   
Sbjct: 461 ECDLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASET 519

Query: 567 CYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYH 626
           CY++LN  G   G CG K + +++C+  DV CG + C N++  P + D      +   + 
Sbjct: 520 CYKELNTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSD-----HTTVHWA 574

Query: 627 QGKELDCRGGHVQLA-DGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRI 685
           +  ++ C      L   G D+  V+DGT CG + +C+   C+  +  N +  P       
Sbjct: 575 RFNDIMCWSTDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPA-----F 629

Query: 686 CSHHGVCSNEGKCICQPDWTGKDCSIH---NPLPTSPPTGETERYK 728
           C+  G+C+N+  C C   W   +C I      + + PP    ++ K
Sbjct: 630 CNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKK 675


>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
           sapiens]
          Length = 735

 Score =  249 bits (635), Expect = 9e-66
 Identities = 170/606 (28%), Positives = 269/606 (44%), Gaps = 70/606 (11%)

Query: 133 CYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTP 192
           C+YQG + G P S   +STC GL GV    N++Y +EP E +  +        H+IY+  
Sbjct: 92  CHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGF-------EHVIYQVK 144

Query: 193 LLPDPLGCREPGCL----FAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVIND 248
                +       +     +   QS  P +                    KY+E+ VI +
Sbjct: 145 HKKADVSLYNEKDIESRDLSFKLQSVEPQQ-----------------DFAKYIEMHVIVE 187

Query: 249 HQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLET 308
            QL+  M     + +     ++ L + I+    N  I+L ++E W D +KI    +  E 
Sbjct: 188 KQLYNHMGSDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANEL 246

Query: 309 LARLMVYRREGLP-EPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYG---NMG 364
           L   + ++   L   P D   L   R  +S   GA + G +C  ++ GGV  +    ++ 
Sbjct: 247 LHTFLRWKTSYLVLRPHDVAFLLVYRE-KSNYVGATFQGKMCDANYAGGVVLHPRTISLE 305

Query: 365 AMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLP--RKFSRCSIDEY 422
           ++AV LAQ L  ++G+ ++        C+C      CIM     +    + FS CS +++
Sbjct: 306 SLAVILAQLLSLSMGITYD----DINKCQCSGAV--CIMNPEAIHFSGVKIFSNCSFEDF 359

Query: 423 NQFLQEGGGSCLFNKPLKLLDP-----PECGNGFVEAGEECDCGSVQECSRAGGNCCK-- 475
             F+ +    CL N+P   LDP       CGN  +EAGEECDCG+ Q+C+  G  CC   
Sbjct: 360 AHFISKQKSQCLHNQPR--LDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIA 417

Query: 476 KCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYC 535
            C     + C++G CC  C +  +   CR +  ECD+ E C G S+ CP N +   G+ C
Sbjct: 418 TCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPC 477

Query: 536 DHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSGWVQCSK 593
              Q  C  G C + D+QC   +G         CY  LN +    G+CG   SG+ QC  
Sbjct: 478 GLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEA 537

Query: 594 QDVLCGFLLCVNIS----GAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYV 649
            ++ CG L+C  +       PR   +  +IS     H    ++    H      S   ++
Sbjct: 538 DNLQCGKLICKYVGKFLLQIPRATIIYANISG----HLCIAVEFASDHAD----SQKMWI 589

Query: 650 EDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDC 709
           +DGT+CG N +C + RC+ +S   +           C+  GVC+N+  C C   +   DC
Sbjct: 590 KDGTSCGSNKVCRNQRCVSSSYLGYDCTTDK-----CNDRGVCNNKKHCHCSASYLPPDC 644

Query: 710 SIHNPL 715
           S+ + L
Sbjct: 645 SVQSDL 650


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.450 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,724,010
Number of Sequences: 37866
Number of extensions: 2073339
Number of successful extensions: 7327
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 99
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 5916
Number of HSP's gapped (non-prelim): 1099
length of query: 769
length of database: 18,247,518
effective HSP length: 110
effective length of query: 659
effective length of database: 14,082,258
effective search space: 9280208022
effective search space used: 9280208022
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.