Search of human proteins with 13162290

Search of human proteins with 13162290

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13162290 betaine-homocysteine methyltransferase 2 [Homo
sapiens]
         (363 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13162290 betaine-homocysteine methyltransferase 2 [Homo sapiens]   753   0.0  
gi|157266337 betaine-homocysteine methyltransferase [Homo sapiens]    584   e-167
gi|169790923 5-methyltetrahydrofolate-homocysteine methyltransfe...    51   1e-06
gi|108773804 Fraser syndrome 1 [Homo sapiens]                          31   2.0  
gi|7657253 T-complex protein 1 [Homo sapiens]                          31   2.0  
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]             30   4.4  
gi|30794472 hyaluronan and proteoglycan link protein 4 [Homo sap...    28   9.8  

>gi|13162290 betaine-homocysteine methyltransferase 2 [Homo sapiens]
          Length = 363

 Score =  753 bits (1944), Expect = 0.0
 Identities = 363/363 (100%), Positives = 363/363 (100%)

Query: 1   MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH 60
           MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH
Sbjct: 1   MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH 60

Query: 61  MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK 120
           MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK
Sbjct: 61  MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK 120

Query: 121 YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP 180
           YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP
Sbjct: 121 YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP 180

Query: 181 EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL 240
           EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL
Sbjct: 181 EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL 240

Query: 241 GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA 300
           GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA
Sbjct: 241 GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA 300

Query: 301 IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK 360
           IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK
Sbjct: 301 IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK 360

Query: 361 PDF 363
           PDF
Sbjct: 361 PDF 363


>gi|157266337 betaine-homocysteine methyltransferase [Homo sapiens]
          Length = 406

 Score =  584 bits (1506), Expect = e-167
 Identities = 282/371 (76%), Positives = 312/371 (84%), Gaps = 9/371 (2%)

Query: 1   MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH 60
           M P G   AKKGILERL +GE+VIGDG F+  LEKRGYVKAG WTPEA +EHP+AVRQLH
Sbjct: 1   MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH 60

Query: 61  MEFLRAGSNVMQTFTFSASEDNMESKW---------EDVNAAACDLAREVAGKGDALVAG 111
            EFLRAGSNVMQTFTF ASED +E++          ++VN AACD+AR+VA +GDALVAG
Sbjct: 61  REFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAG 120

Query: 112 GICQTSIYKYQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRP 171
           G+ QT  Y   K E  +KK+F QQLEVF  KNVDFLIAEYFEHVEEAVWAVE L  S +P
Sbjct: 121 GVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKP 180

Query: 172 VAVTMCIGPEGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGL 231
           VA TMCIGPEGD+H + PGECAVRLVKAGASI+GVNC F P  SLKT++LMKEGLE A L
Sbjct: 181 VAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARL 240

Query: 232 KAHLMVQPLGFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCC 291
           KAHLM QPL +H PDC K+GF+DLPE+PFGLE RVATRWDIQKYAREAYNLGVRYIGGCC
Sbjct: 241 KAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC 300

Query: 292 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASG 351
           GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPW+RARAR+EYWENL  ASG
Sbjct: 301 GFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASG 360

Query: 352 RPFCPSLSKPD 362
           RP+ PS+SKPD
Sbjct: 361 RPYNPSMSKPD 371


>gi|169790923 5-methyltetrahydrofolate-homocysteine
           methyltransferase [Homo sapiens]
          Length = 1265

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 70/302 (23%), Positives = 131/302 (43%), Gaps = 51/302 (16%)

Query: 50  IEHPDAVRQLHMEFLRAGSNVMQTFTFSAS-----EDNMESKWEDVNAAACDLAREVAGK 104
           I  PD + Q+H E+L AG+++++T TFS++     +  +E     +N  +  +AR+ A +
Sbjct: 72  ITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEE 131

Query: 105 GDA------LVAGGICQTSIY-----KYQKDEAR------IKKLFRQQLEVFAWKNVDFL 147
                     VAG +  T+         ++ + R      + + +++Q +      VD L
Sbjct: 132 VTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDIL 191

Query: 148 IAEYF---EHVEEAVWAVEVL---KESDRPVAVT-MCIGPEGDMHDITPGECAVRLVKAG 200
           + E      + + A++A++ L   K + RP+ ++   +   G       GE  V  V  G
Sbjct: 192 LIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHG 251

Query: 201 ASI-VGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPLGFHAPDCGKEG-FVDLPEY 258
             + +G+NC  G       +E++ +        A+++  P      + G    F D  E 
Sbjct: 252 EPLCIGLNCALGAAEMRPFIEIIGKCTT-----AYVLCYP------NAGLPNTFGDYDET 300

Query: 259 PFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEK 318
           P  +         ++ +A +     V  +GGCCG  P HIR IAE +   +  +PPA+  
Sbjct: 301 PSMMAKH------LKDFAMDGL---VNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAF 351

Query: 319 HG 320
            G
Sbjct: 352 EG 353


>gi|108773804 Fraser syndrome 1 [Homo sapiens]
          Length = 4011

 Score = 30.8 bits (68), Expect = 2.0
 Identities = 38/155 (24%), Positives = 65/155 (41%), Gaps = 19/155 (12%)

Query: 60   HMEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIY 119
            H    R G N M T T S  ED    ++E+    A    RE AG  DA+    I    + 
Sbjct: 3016 HWSGARIGKNNMATITISNDEDAPTIEFEE----AAYQVREPAGP-DAI---AILNIKVI 3067

Query: 120  KYQKDEARIKKLFRQQLEVFAWKNVDFL----IAEYFEHVEEAVWAVEVLKESDRP--VA 173
            + + D+ R  K+     +  A   VD+     + ++   V+   + VE+L   DR    +
Sbjct: 3068 R-RGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHES 3126

Query: 174  VTMCIGP----EGDMHDITPGECAVRLVKAGASIV 204
             ++ +GP    E  + D+T     +   +A  S++
Sbjct: 3127 FSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLI 3161


>gi|7657253 T-complex protein 1 [Homo sapiens]
          Length = 557

 Score = 30.8 bits (68), Expect = 2.0
 Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 9/67 (13%)

Query: 155 VEEAVWAVEVLKESDRPVAVTMCIGPEGDMHD--ITPGEC-------AVRLVKAGASIVG 205
           V  A WA++ L  S +P  V +C  P G + D  + PG          +  V +GA +  
Sbjct: 184 VAHACWAIKELDGSFKPERVGVCALPGGTLEDSCLLPGLAISGKLCGQMATVLSGARVAL 243

Query: 206 VNCRFGP 212
             C FGP
Sbjct: 244 FACPFGP 250


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score = 29.6 bits (65), Expect = 4.4
 Identities = 18/58 (31%), Positives = 31/58 (53%)

Query: 144 VDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGPEGDMHDITPGECAVRLVKAGA 201
           VD L +EY +   + V +V  +KE D  V V + +G EG+       E  +R++ +G+
Sbjct: 116 VDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGS 173


>gi|30794472 hyaluronan and proteoglycan link protein 4 [Homo
           sapiens]
          Length = 402

 Score = 28.5 bits (62), Expect = 9.8
 Identities = 16/50 (32%), Positives = 21/50 (42%), Gaps = 9/50 (18%)

Query: 295 PYHIRAIAEEL---------APERGFLPPASEKHGSWGSGLDMHTKPWIR 335
           PYH R    +L         A + G L  A + H +W  GLD     W+R
Sbjct: 166 PYHPRGGRYKLTFAEAQRACAEQDGILASAEQLHAAWRDGLDWCNAGWLR 215


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.433 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,063,264
Number of Sequences: 37866
Number of extensions: 671742
Number of successful extensions: 1377
Number of sequences better than 10.0: 7
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1371
Number of HSP's gapped (non-prelim): 8
length of query: 363
length of database: 18,247,518
effective HSP length: 104
effective length of query: 259
effective length of database: 14,309,454
effective search space: 3706148586
effective search space used: 3706148586
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.