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Search of human proteins with 4501915
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor
[Homo sapiens]
(819 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 1728 0.0
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 525 e-149
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 524 e-148
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 515 e-146
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 515 e-146
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 515 e-146
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 515 e-146
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 506 e-143
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 503 e-142
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 497 e-140
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 485 e-137
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 484 e-136
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 452 e-127
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 443 e-124
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 431 e-120
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 429 e-120
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 427 e-119
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 426 e-119
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 426 e-119
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 420 e-117
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 410 e-114
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 410 e-114
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 400 e-111
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 395 e-110
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 366 e-101
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 334 2e-91
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot... 333 3e-91
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s... 333 4e-91
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 329 7e-90
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 328 9e-90
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 1728 bits (4476), Expect = 0.0
Identities = 819/819 (100%), Positives = 819/819 (100%)
Query: 1 MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPR 60
MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPR
Sbjct: 1 MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPR 60
Query: 61 PYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYV 120
PYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYV
Sbjct: 61 PYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYV 120
Query: 121 EGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNK 180
EGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNK
Sbjct: 121 EGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNK 180
Query: 181 DIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMI 240
DIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMI
Sbjct: 181 DIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMI 240
Query: 241 LLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDS 300
LLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDS
Sbjct: 241 LLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDS 300
Query: 301 AQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDG 360
AQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDG
Sbjct: 301 AQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDG 360
Query: 361 RDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
RDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK
Sbjct: 361 RDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
Query: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSEC 480
LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSEC
Sbjct: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSEC 480
Query: 481 DVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCF 540
DVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCF
Sbjct: 481 DVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCF 540
Query: 541 IEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKC 600
IEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKC
Sbjct: 541 IEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKC 600
Query: 601 WGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNK 660
WGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNK
Sbjct: 601 WGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNK 660
Query: 661 NCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKR 720
NCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKR
Sbjct: 661 NCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKR 720
Query: 721 DQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAA 780
DQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAA
Sbjct: 721 DQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAA 780
Query: 781 KQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT 819
KQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
Sbjct: 781 KQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT 819
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 525 bits (1353), Expect = e-149
Identities = 266/710 (37%), Positives = 420/710 (59%), Gaps = 24/710 (3%)
Query: 12 LRVRWLLL-LGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVI 70
+RV LLL LG+ + G + G Q H +S E++ P ++ R A P +SY +
Sbjct: 10 IRVTLLLLWLGVFLSISGYCQAGPSQ--HFTSPEVVIPLKVISRGRSAKAP--GWLSYSL 65
Query: 71 QAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIAL 130
+ G++H++H+ K L+ V+TY E L+ D I + C+Y GYVEG S +
Sbjct: 66 RFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVF 125
Query: 131 SDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMD--DVYKEPLKCGVSNKDIEKETA 187
S CFG RG+L + +Y IEP+++S+ FEH++Y+++ + ++CG++ K++ ++
Sbjct: 126 SACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQL 185
Query: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
+ EE E ++ + ++EL +VV+ + + N + V+E++ L+ N +D
Sbjct: 186 EFEEAENSALEP--KSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVD 243
Query: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
SMY L I+L+G+EIW GN+ + VL +F QW++ +++ +HD+A + +K
Sbjct: 244 SMYQQLGTYIILIGIEIWNQGNVFPMTS-IEQVLNDFSQWKQ-ISLSQLQHDAAHMFIKN 301
Query: 308 GFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGA 367
G+A+V +C G++ F T FA+ VAHELGH LGM HD+ C CG
Sbjct: 302 SLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDE-EFCFCGE 360
Query: 368 KSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427
+ CIMN+ + F++CS DF K TLN+G +CL N P+ E + CGN +V+ E+
Sbjct: 361 RGCIMNTFRVPAEKFTNCSYADFMKTTLNQG-SCLHNPPRLGEIFMLKRCGNGVVEREEQ 419
Query: 428 CDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCN 487
CDCG+ ++CE D CC C L+ A CA+G CCKDC+F+P G LCR + +ECD+PE+CN
Sbjct: 420 CDCGSVQQCEQDACCL-LNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCN 478
Query: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547
G+S C D ++Q+G PC ++ AYCY C +D C+ IFG AK+A ++C+ E+NS+G
Sbjct: 479 GTSHQCPEDRYVQDGIPCSDS-AYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQG 537
Query: 548 DRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQL 607
+RFG+CG +G Y KC + CG++QCENV++IP+ + T G CWG+D+ L
Sbjct: 538 NRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHINGVTCWGIDYHL 597
Query: 608 GSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENG 667
++ D G V +GT CG GKIC + +CV SVL++ C + + C+ G+CN+ +CHC G
Sbjct: 598 RMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVC-LPETCNMKGICNNKHHCHCGYG 656
Query: 668 WAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIF 717
W+PP C+ +GYGGS+DSGP + L +++P + F+F
Sbjct: 657 WSPPYCQHRGYGGSIDSGPASAKRGVFLP-------LIVIPSLSVLTFLF 699
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 524 bits (1350), Expect = e-148
Identities = 310/802 (38%), Positives = 436/802 (54%), Gaps = 67/802 (8%)
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGT---LITDHPNIQNHCHYRGYVEGVHNS 126
+Q E KE II+LERN+ L+ F Y ++GT L ++ I HC+Y G+V G +S
Sbjct: 72 LQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDS 131
Query: 127 SIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKET 186
+++LS C GLRGL+ EN SY +EP++++++ + ++ + CG S+ +
Sbjct: 132 AVSLSTCSGLRGLIVFENESYVLEPMKSATN-RYKLFPAKKLKSVRGSCG-SHHNTPNLA 189
Query: 187 AKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYL 246
AK+ PPS T R +R L T+YVEL IV D + G++ V++ +I +AN++
Sbjct: 190 AKNVFP-PPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
Query: 247 DSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLK 306
D Y LNIRIVLVG+E+W + + ++ L F+ WR+ L+ R+ HD+AQLV
Sbjct: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
Query: 307 KGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDD-GRDCS 364
F GT GMA + ++C+ +GGI + A +AHELGHN GMNHD R CS
Sbjct: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
Query: 365 CGAK----SCIMNS--GASGSRNFSSCSAEDFEKLTLNKG-GNCLLNIPKPDEAYSAPSC 417
C CIMN+ G FSSCS +D E +L KG G CL N+P+ E++ C
Sbjct: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLET-SLEKGMGVCLFNLPEVRESFGGQKC 427
Query: 418 GNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKT 477
GN+ V+ GEECDCG P+EC ++ CC +TC LK A CA+G CC+DC+ P GT CR +
Sbjct: 428 GNRFVEEGEECDCGEPEEC-MNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS 486
Query: 478 SECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPK 537
+ CD+PE+C G+S C +V++ +G+ CQ+ YCYNG+CQ ++ QC ++G AK AP
Sbjct: 487 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG 546
Query: 538 DCFIEVNSKGDRFGNCG-FSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTP-- 594
CF VNS GD +GNCG S + + KC +A CGK+QC+ PV G I+T
Sbjct: 547 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP 606
Query: 595 -SRGTK--CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLN-YDCDVQKKC 650
+G + C G LG D+PDPG+V GTKC GKIC N QC + SV ++C +Q C
Sbjct: 607 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ--C 664
Query: 651 HGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLI 710
HG GVCN+ KNCHCE WAPP C+ G+GGS DSGP N L G+LV I+ L+
Sbjct: 665 HGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILV---TILCLL 721
Query: 711 VCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSR--QPGSV-------------PR 755
+++KR L R F K++ + + P R QP P
Sbjct: 722 AAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPD 781
Query: 756 HVSPVTPPREV-------------------PIYANRFAVPTYAAKQPQQFPSRPPPPQPK 796
P PR + P R P + A + P+RP P +P
Sbjct: 782 SYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPA 841
Query: 797 V-SSQGNL---IPARPAPAPPL 814
+ +QG P +P PA PL
Sbjct: 842 LRQAQGTCKPNPPQKPLPADPL 863
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 515 bits (1326), Expect = e-146
Identities = 281/803 (34%), Positives = 430/803 (53%), Gaps = 30/803 (3%)
Query: 14 VRWLLLLGLVGPVLGAARPGFQQTSHLSSY---EIITPWRLTRERREAPRPYSKQVSYVI 70
++ LLLL +G L + G Q H + +++ P R+T R P +SY++
Sbjct: 1 MKMLLLLHCLGVFLSCS--GHIQDEHPQYHSPPDVVIPVRITGTTRGMTPP--GWLSYIL 56
Query: 71 QAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIAL 130
G++HIIH++ K L + V+TY +G ++ D P +QN+C+Y GYVEG S ++L
Sbjct: 57 PFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSL 116
Query: 131 SDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKE--PLKCGVSNKDIEKETA 187
S CFG +G+L + + +Y I+PL S+ FEH++Y+MD K+ ++ G +I T
Sbjct: 117 STCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---TC 173
Query: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
+ E EE + TQ R VE+ +V+D Y RN + + E++ ++ N +D
Sbjct: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233
Query: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
S+ ++ ++++L GLEIWTN NLI +V + + +W+ + + R +HD++ L
Sbjct: 234 SILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTL 292
Query: 308 GFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGA 367
G G +G+ +C+ + I F T+ TF+ VAH LGHNLGMNHD+ C C
Sbjct: 293 GLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT-CRCSQ 351
Query: 368 KSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427
CIM+ G FS+CS DF + T+ + CLL + ++ CGN +V+ GEE
Sbjct: 352 PRCIMHEGNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEEGEE 410
Query: 428 CDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCN 487
CDCG K C DPCC S C L + CA+G CCKDC+FLP G +CR + +ECD+PE+CN
Sbjct: 411 CDCGPLKHCAKDPCCL-SNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCN 469
Query: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547
G+S C D ++++G PC+ + YCY C + QC+ IFG+ A A + C+ E+N+ G
Sbjct: 470 GTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLG 528
Query: 548 DRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQL 607
DR G+CG Y KC + CG++QCENV EIP + CW D+ L
Sbjct: 529 DRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHL 588
Query: 608 GSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENG 667
G PD G V +GT+CG IC + CV ++LN +C C+ G+CN+ +CHC
Sbjct: 589 GMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCS-PAFCNKRGICNNKHHCHCNYL 647
Query: 668 WAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSY 727
W PPNC KGYGGSVDSGP L + +++ +++C ++ K +S
Sbjct: 648 WDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCK-----KSK 702
Query: 728 FRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFP 787
KK+ K + R+P +P P + P +P + P+ + PQ P
Sbjct: 703 PIKKQQDVQTPSAKEEEKIQRRPHELP----PQSQPWVMPSQSQPPVTPSQS--HPQVMP 756
Query: 788 SRPPPPQPKVSSQGNLIPARPAP 810
S+ PP SQ ++P++ P
Sbjct: 757 SQSQPPVTPSQSQPRVMPSQSQP 779
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 515 bits (1326), Expect = e-146
Identities = 281/803 (34%), Positives = 430/803 (53%), Gaps = 30/803 (3%)
Query: 14 VRWLLLLGLVGPVLGAARPGFQQTSHLSSY---EIITPWRLTRERREAPRPYSKQVSYVI 70
++ LLLL +G L + G Q H + +++ P R+T R P +SY++
Sbjct: 1 MKMLLLLHCLGVFLSCS--GHIQDEHPQYHSPPDVVIPVRITGTTRGMTPP--GWLSYIL 56
Query: 71 QAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIAL 130
G++HIIH++ K L + V+TY +G ++ D P +QN+C+Y GYVEG S ++L
Sbjct: 57 PFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSL 116
Query: 131 SDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKE--PLKCGVSNKDIEKETA 187
S CFG +G+L + + +Y I+PL S+ FEH++Y+MD K+ ++ G +I T
Sbjct: 117 STCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---TC 173
Query: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
+ E EE + TQ R VE+ +V+D Y RN + + E++ ++ N +D
Sbjct: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233
Query: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
S+ ++ ++++L GLEIWTN NLI +V + + +W+ + + R +HD++ L
Sbjct: 234 SILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTL 292
Query: 308 GFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGA 367
G G +G+ +C+ + I F T+ TF+ VAH LGHNLGMNHD+ C C
Sbjct: 293 GLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT-CRCSQ 351
Query: 368 KSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427
CIM+ G FS+CS DF + T+ + CLL + ++ CGN +V+ GEE
Sbjct: 352 PRCIMHEGNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEEGEE 410
Query: 428 CDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCN 487
CDCG K C DPCC S C L + CA+G CCKDC+FLP G +CR + +ECD+PE+CN
Sbjct: 411 CDCGPLKHCAKDPCCL-SNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCN 469
Query: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547
G+S C D ++++G PC+ + YCY C + QC+ IFG+ A A + C+ E+N+ G
Sbjct: 470 GTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLG 528
Query: 548 DRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQL 607
DR G+CG Y KC + CG++QCENV EIP + CW D+ L
Sbjct: 529 DRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHL 588
Query: 608 GSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENG 667
G PD G V +GT+CG IC + CV ++LN +C C+ G+CN+ +CHC
Sbjct: 589 GMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCS-PAFCNKRGICNNKHHCHCNYL 647
Query: 668 WAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSY 727
W PPNC KGYGGSVDSGP L + +++ +++C ++ K +S
Sbjct: 648 WDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCK-----KSK 702
Query: 728 FRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFP 787
KK+ K + R+P +P P + P +P + P+ + PQ P
Sbjct: 703 PIKKQQDVQTPSAKEEEKIQRRPHELP----PQSQPWVMPSQSQPPVTPSQS--HPQVMP 756
Query: 788 SRPPPPQPKVSSQGNLIPARPAP 810
S+ PP SQ ++P++ P
Sbjct: 757 SQSQPPVTPSQSQPRVMPSQSQP 779
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 515 bits (1326), Expect = e-146
Identities = 281/803 (34%), Positives = 430/803 (53%), Gaps = 30/803 (3%)
Query: 14 VRWLLLLGLVGPVLGAARPGFQQTSHLSSY---EIITPWRLTRERREAPRPYSKQVSYVI 70
++ LLLL +G L + G Q H + +++ P R+T R P +SY++
Sbjct: 1 MKMLLLLHCLGVFLSCS--GHIQDEHPQYHSPPDVVIPVRITGTTRGMTPP--GWLSYIL 56
Query: 71 QAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIAL 130
G++HIIH++ K L + V+TY +G ++ D P +QN+C+Y GYVEG S ++L
Sbjct: 57 PFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSL 116
Query: 131 SDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKE--PLKCGVSNKDIEKETA 187
S CFG +G+L + + +Y I+PL S+ FEH++Y+MD K+ ++ G +I T
Sbjct: 117 STCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---TC 173
Query: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
+ E EE + TQ R VE+ +V+D Y RN + + E++ ++ N +D
Sbjct: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233
Query: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
S+ ++ ++++L GLEIWTN NLI +V + + +W+ + + R +HD++ L
Sbjct: 234 SILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTL 292
Query: 308 GFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGA 367
G G +G+ +C+ + I F T+ TF+ VAH LGHNLGMNHD+ C C
Sbjct: 293 GLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT-CRCSQ 351
Query: 368 KSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427
CIM+ G FS+CS DF + T+ + CLL + ++ CGN +V+ GEE
Sbjct: 352 PRCIMHEGNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEEGEE 410
Query: 428 CDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCN 487
CDCG K C DPCC S C L + CA+G CCKDC+FLP G +CR + +ECD+PE+CN
Sbjct: 411 CDCGPLKHCAKDPCCL-SNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCN 469
Query: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547
G+S C D ++++G PC+ + YCY C + QC+ IFG+ A A + C+ E+N+ G
Sbjct: 470 GTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLG 528
Query: 548 DRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQL 607
DR G+CG Y KC + CG++QCENV EIP + CW D+ L
Sbjct: 529 DRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHL 588
Query: 608 GSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENG 667
G PD G V +GT+CG IC + CV ++LN +C C+ G+CN+ +CHC
Sbjct: 589 GMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCS-PAFCNKRGICNNKHHCHCNYL 647
Query: 668 WAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSY 727
W PPNC KGYGGSVDSGP L + +++ +++C ++ K +S
Sbjct: 648 WDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCK-----KSK 702
Query: 728 FRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFP 787
KK+ K + R+P +P P + P +P + P+ + PQ P
Sbjct: 703 PIKKQQDVQTPSAKEEEKIQRRPHELP----PQSQPWVMPSQSQPPVTPSQS--HPQVMP 756
Query: 788 SRPPPPQPKVSSQGNLIPARPAP 810
S+ PP SQ ++P++ P
Sbjct: 757 SQSQPPVTPSQSQPRVMPSQSQP 779
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 515 bits (1326), Expect = e-146
Identities = 281/803 (34%), Positives = 430/803 (53%), Gaps = 30/803 (3%)
Query: 14 VRWLLLLGLVGPVLGAARPGFQQTSHLSSY---EIITPWRLTRERREAPRPYSKQVSYVI 70
++ LLLL +G L + G Q H + +++ P R+T R P +SY++
Sbjct: 1 MKMLLLLHCLGVFLSCS--GHIQDEHPQYHSPPDVVIPVRITGTTRGMTPP--GWLSYIL 56
Query: 71 QAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIAL 130
G++HIIH++ K L + V+TY +G ++ D P +QN+C+Y GYVEG S ++L
Sbjct: 57 PFGGQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSL 116
Query: 131 SDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKE--PLKCGVSNKDIEKETA 187
S CFG +G+L + + +Y I+PL S+ FEH++Y+MD K+ ++ G +I T
Sbjct: 117 STCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEI---TC 173
Query: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
+ E EE + TQ R VE+ +V+D Y RN + + E++ ++ N +D
Sbjct: 174 RMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVD 233
Query: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
S+ ++ ++++L GLEIWTN NLI +V + + +W+ + + R +HD++ L
Sbjct: 234 SILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTL 292
Query: 308 GFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGA 367
G G +G+ +C+ + I F T+ TF+ VAH LGHNLGMNHD+ C C
Sbjct: 293 GLRGLSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDT-CRCSQ 351
Query: 368 KSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427
CIM+ G FS+CS DF + T+ + CLL + ++ CGN +V+ GEE
Sbjct: 352 PRCIMHEGNPPITKFSNCSYGDFWEYTVERT-KCLLETVHTKDIFNVKRCGNGVVEEGEE 410
Query: 428 CDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCN 487
CDCG K C DPCC S C L + CA+G CCKDC+FLP G +CR + +ECD+PE+CN
Sbjct: 411 CDCGPLKHCAKDPCCL-SNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCN 469
Query: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547
G+S C D ++++G PC+ + YCY C + QC+ IFG+ A A + C+ E+N+ G
Sbjct: 470 GTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLG 528
Query: 548 DRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQL 607
DR G+CG Y KC + CG++QCENV EIP + CW D+ L
Sbjct: 529 DRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHWARFNDIMCWSTDYHL 588
Query: 608 GSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENG 667
G PD G V +GT+CG IC + CV ++LN +C C+ G+CN+ +CHC
Sbjct: 589 GMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCS-PAFCNKRGICNNKHHCHCNYL 647
Query: 668 WAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSY 727
W PPNC KGYGGSVDSGP L + +++ +++C ++ K +S
Sbjct: 648 WDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILLCCLYRLCK-----KSK 702
Query: 728 FRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFP 787
KK+ K + R+P +P P + P +P + P+ + PQ P
Sbjct: 703 PIKKQQDVQTPSAKEEEKIQRRPHELP----PQSQPWVMPSQSQPPVTPSQS--HPQVMP 756
Query: 788 SRPPPPQPKVSSQGNLIPARPAP 810
S+ PP SQ ++P++ P
Sbjct: 757 SQSQPPVTPSQSQPRVMPSQSQP 779
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 506 bits (1303), Expect = e-143
Identities = 279/724 (38%), Positives = 401/724 (55%), Gaps = 31/724 (4%)
Query: 12 LRVRWLLL-LGLVGPVLG--AARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSY 68
+RV LLL G+ + G ARP + + +S E++ P ++ R A P +SY
Sbjct: 60 IRVTLLLLWFGMFLSISGHSQARP----SQYFTSPEVVIPLKVISRGRGAKAP--GWLSY 113
Query: 69 VIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSI 128
++ G+ +I+H+ NK L V+TY ++ L+ D P IQ+ C+Y GYVEGV S +
Sbjct: 114 SLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLV 173
Query: 129 ALSDCFG-LRGLLHLENASYGIEPLQNSSHFEHIIYRMD--DVYKEPLKCGVSNKDIEKE 185
ALS C G G+L + + Y I+P+ S+ FEH++Y++D D P++CG++ + I +
Sbjct: 174 ALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQ 233
Query: 186 TAKDEEEEPPSMTQLLRRRRAV--LPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLA 243
E S L++ V R+VEL +VVD RY N T V+ E+ +
Sbjct: 234 M-----ELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVV 288
Query: 244 NYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQL 303
N +DS Y L + ++L G++IWT N + G +VL +F W+ L R +HD A L
Sbjct: 289 NIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHL 348
Query: 304 VLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDC 363
+K G G+A+V +C G++VF + FA + HELGHNLGM HD + C
Sbjct: 349 FIKDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDT-QWC 407
Query: 364 SCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVD 423
C + CIM++ + FS+CS + T++ G C+ P P + CGN +V+
Sbjct: 408 VCELQWCIMHAYRKVTTKFSNCSYAQYWDSTIS-SGLCIQPPPYPGNIFRLKYCGNLVVE 466
Query: 424 AGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVP 483
GEECDCGT ++C DPCC C L A CA+G CCKDC+FLP GTLCR + ECD+P
Sbjct: 467 EGEECDCGTIRQCAKDPCCL-LNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLP 525
Query: 484 EYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEV 543
E+CNG+S C DV++Q+G C N A+CY C +D QC+ IFG A++A + C+ E+
Sbjct: 526 EWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEI 584
Query: 544 NSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGV 603
N++G+RFG+CG G Y KC T + +CG++QCENV IP + Q T CWG
Sbjct: 585 NTQGNRFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLNDTTCWGT 644
Query: 604 DFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCH 663
D+ LG +PD G V +GT CG KIC +C L+ C K C+ G+CN+ ++CH
Sbjct: 645 DYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQ-PKTCNMRGICNNKQHCH 703
Query: 664 CENGWAPPNCETKGYGGSVDSGPT-------YNEMNTALRDGLLVFFFLIVPLIVCAIFI 716
C + WAPP C+ KGYGGS DSGP N M LL L+ L+ C +
Sbjct: 704 CNHEWAPPYCKDKGYGGSADSGPPPKNNMEGLNVMGKLRYLSLLCLLPLVAFLLFCLHVL 763
Query: 717 FIKR 720
F KR
Sbjct: 764 FKKR 767
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 503 bits (1295), Expect = e-142
Identities = 272/636 (42%), Positives = 380/636 (59%), Gaps = 26/636 (4%)
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGT---LITDHPNIQNHCHYRGYVEGVHNS 126
+Q E KE II+LERN+ L+ F Y ++GT L ++ I HC+Y G+V G +S
Sbjct: 72 LQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDS 131
Query: 127 SIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKET 186
+++LS C GLRGL+ EN SY +EP++++++ + ++ + CG S+ +
Sbjct: 132 AVSLSTCSGLRGLIVFENESYVLEPMKSATN-RYKLFPAKKLKSVRGSCG-SHHNTPNLA 189
Query: 187 AKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYL 246
AK+ PPS T R +R L T+YVEL IV D + G++ V++ +I +AN++
Sbjct: 190 AKNVFP-PPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
Query: 247 DSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLK 306
D Y LNIRIVLVG+E+W + + ++ L F+ WR+ L+ R+ HD+AQLV
Sbjct: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
Query: 307 KGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDD-GRDCS 364
F GT GMA + ++C+ +GGI + A +AHELGHN GMNHD R CS
Sbjct: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
Query: 365 CGAK----SCIMNS--GASGSRNFSSCSAEDFEKLTLNKG-GNCLLNIPKPDEAYSAPSC 417
C CIMN+ G FSSCS +D E +L KG G CL N+P+ E++ C
Sbjct: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLET-SLEKGMGVCLFNLPEVRESFGGQKC 427
Query: 418 GNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKT 477
GN+ V+ GEECDCG P+EC ++ CC +TC LK A CA+G CC+DC+ P GT CR +
Sbjct: 428 GNRFVEEGEECDCGEPEEC-MNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS 486
Query: 478 SECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPK 537
+ CD+PE+C G+S C +V++ +G+ CQ+ YCYNG+CQ ++ QC ++G AK AP
Sbjct: 487 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG 546
Query: 538 DCFIEVNSKGDRFGNCG-FSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTP-- 594
CF VNS GD +GNCG S + + KC +A CGK+QC+ PV G I+T
Sbjct: 547 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP 606
Query: 595 -SRGTK--CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLN-YDCDVQKKC 650
+G + C G LG D+PDPG+V GTKC GKIC N QC + SV ++C +Q C
Sbjct: 607 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ--C 664
Query: 651 HGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGP 686
HG GVCN+ KNCHCE WAPP C+ G+GGS DSGP
Sbjct: 665 HGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 497 bits (1280), Expect = e-140
Identities = 315/876 (35%), Positives = 443/876 (50%), Gaps = 84/876 (9%)
Query: 8 PSGTLRVRWLLLLGLVGPVL--GAARPGFQQTSHLSS----YEIITP-WRLTRERREAPR 60
P G R LL + P+ A PG+ + S S +E+I P W+ +
Sbjct: 2 PGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREKH 61
Query: 61 PYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYV 120
P ++ + AEG+E I+ LE+N+ L + Y G T +++HC Y G V
Sbjct: 62 PLKAELR--VMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTV 119
Query: 121 EGVHNSSIALSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSN 179
SS+ LS C G+RGL+ + N SY IEPL +S +H+IYR + + P CG +
Sbjct: 120 RETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKG-QHLIYRSEHLKPPPGNCGFEH 178
Query: 180 KDIEKETAKDEEEEPPSMTQLLRRR--RAVLPQTRYVELFIVVDKERYDMMGRNQTAVRE 237
K T +D + T+ RR R L +YVEL++V D + R+Q A +
Sbjct: 179 S---KPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKH 235
Query: 238 EMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRR 297
++I +ANY+D Y LNIRI LVGLE+WT+GN+ + L +F+ WR K L+ ++
Sbjct: 236 KLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRK-LLAQKY 294
Query: 298 HDSAQLVLKKGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMN 356
HD+AQL+ F GT G+A + +CS +GG+N+ A+ +AHE+GHN GM
Sbjct: 295 HDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMT 354
Query: 357 HDDGRDCSCGAKS--CIMNS--GASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAY 412
HD CS A CIM + G + F+ C+ + ++ + GG CL N+P Y
Sbjct: 355 HDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLY 414
Query: 413 SAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTL 472
CGN ++ GEECDCG +EC +PCC S C L+ AECA+G CC C+ L GTL
Sbjct: 415 GGRRCGNGYLEDGEECDCGEEEECN-NPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTL 473
Query: 473 CRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKA 532
CR + +CD+PE+C G S C + + +G PC+ +AYCYNGMC Y QCQ ++G A
Sbjct: 474 CREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGA 533
Query: 533 KAAPKDCFIEVNSKGDRFGNCGFSGN-EYKKCATGNALCGKLQCENVQEIPV-FGIVP-- 588
+ AP CF +VN GD FGNCG N E++KC +A CGK+QC++ + P+ VP
Sbjct: 534 RPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPID 593
Query: 589 AIIQTPSRGTKCWGVDFQLG----SDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDC 644
I R +C G G D+ DPG+V GTKCG IC QC + S +
Sbjct: 594 TTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETE- 652
Query: 645 DVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFF 704
KKC+GHGVCN+N+NCHC GWAPP C T G+GGS+DSGP E + G+LV
Sbjct: 653 GCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLV--- 709
Query: 705 LIVPLIVCAIFIFI-----KRDQLWRSYFRKKRSQTY-------ESDGKNQANPS----- 747
I+ L V + + K QL S K Q + ++ G ANP+
Sbjct: 710 AILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQT 769
Query: 748 --------------RQPGSVPRHVSP-----VTPPREVPIYANRFA----------VPTY 778
R+P P P +PP +P + +R A T
Sbjct: 770 PQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTE 829
Query: 779 AAKQPQQFPSRPPPPQPK-VSSQGNLIPARPAPAPP 813
++++P PSRP PP P + SQ P P A P
Sbjct: 830 SSRRPP--PSRPIPPAPNCIVSQDFSRPRPPQKALP 863
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 485 bits (1248), Expect = e-137
Identities = 274/727 (37%), Positives = 407/727 (55%), Gaps = 34/727 (4%)
Query: 34 FQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFV 93
F SYE+ P +L+ R + VSY++Q +GK+H++HL + LLP
Sbjct: 32 FHPEGEFDSYEVTIPEKLSF--RGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLR 89
Query: 94 VYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFG-LRGLLHLENASYGIEPL 152
V+++ + G L+ DHP I C+Y G V+ +S +S C G LRG+ +++ Y IEPL
Sbjct: 90 VFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPL 149
Query: 153 QNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTR 212
+ S FEH++Y + CG+S+ +IE + A E + LR +
Sbjct: 150 KASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKAR------LRDFPGSYKHPK 203
Query: 213 YVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLIN 272
Y+EL ++ D+ RY + N + V + ILL +D+ + + +RI L LE+WT+ N I
Sbjct: 204 YLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIR 263
Query: 273 I-VGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGIN 331
+ +VLG FV +++ L R D A L L++ + +F G VCS +AG ++
Sbjct: 264 VGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSF-GKVCSLEYAGSVS 322
Query: 332 VFGQITVETFASIVAHELGHNLGMNHDDGRDCSC-GAKSCIMNSGASGSRNFSSCSAEDF 390
+ A+ AHELGH +GM+HD+ + C C G +CIM SG +G FS+CS F
Sbjct: 323 TLLDTNILAPATWSAHELGHAVGMSHDE-QYCQCRGRLNCIMGSGRTG---FSNCSYISF 378
Query: 391 EKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLK 450
K ++ G CL NIP Y CGNK+V+ EECDCG+ +EC+ D CC+ S CKL+
Sbjct: 379 FK-HISSGATCLNNIP--GLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQ-SNCKLQ 434
Query: 451 SFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKA 510
A C+ G CC DCRF P G +CR + +ECD+ EYC+G+S C DV+ Q+G PC+ +
Sbjct: 435 PGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEG 493
Query: 511 YCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSG-NEYKKCATGNAL 569
C+ C+ QCQ IFG A AP +C+ VN GD+FGNC +G +KKC + N++
Sbjct: 494 RCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSI 553
Query: 570 CGKLQCENVQEIPVFGIVPAIIQT--PSRGTKCWGVDFQLG---SDVPDPGMVNEGTKCG 624
CG+LQC NV+ IP II T + CWG + L +PD GM+N+GT CG
Sbjct: 554 CGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCG 613
Query: 625 AGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDS 684
G++C CV++SVL +DC + +KC+ GVCN+ KNCHC GWAPP CE GYGGS+DS
Sbjct: 614 EGRVCFKKNCVNSSVLQFDC-LPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDS 672
Query: 685 GPTYNEMNTALRDGLLV---FFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGK 741
GP + A+ + V F ++ LI+ +F+F + Q+ ++ + K+ + S K
Sbjct: 673 GPP-GLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFR--QVIGNHLKPKQEKMPLSKAK 729
Query: 742 NQANPSR 748
+ S+
Sbjct: 730 TEQEESK 736
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 484 bits (1245), Expect = e-136
Identities = 269/762 (35%), Positives = 416/762 (54%), Gaps = 39/762 (5%)
Query: 16 WLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGK 75
WLLL GL G L A+RPGFQ S +I+ P ++ ++ +Q+SY+I + K
Sbjct: 5 WLLLAGLCG--LLASRPGFQN----SLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEK 58
Query: 76 EHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFG 135
+ +HL++ + L ++F++Y YN +G++ T +IQ C+Y+G +EG +S + LS C G
Sbjct: 59 LYTVHLKQ-RYFLADNFMIYLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSG 116
Query: 136 LRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPP 195
LRG+L EN SYGIEPL+++ F+H++Y++ + + DI + +E+P
Sbjct: 117 LRGILQFENVSYGIEPLESAVEFQHVLYKLKN----------EDNDIAIFIDRSLKEQPM 166
Query: 196 SMTQLLRRR-RAVLPQT--RYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIM 252
+ + +P Y+E+ IVVDK YD G + V ++I + +SM+
Sbjct: 167 DDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQ 226
Query: 253 LNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGT 312
+ IVL LE+W++ N I+ VG A ++L F++W++ +L R HD A L++ +
Sbjct: 227 FKVTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYL-NLRPHDIAYLLIYMDYPRY 285
Query: 313 AGMAFVGTVCSRSHAGGINVFG-QITVETFASIVAHELGHNLGMNHDDGRDCSCGAKSCI 371
G F GT+C ++ G+ ++ +IT+E FA IV L +LG+++DD + C C +CI
Sbjct: 286 LGAVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCI 345
Query: 372 MNSG---ASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEEC 428
MN ++G + FSSCS F+ N G CL N P+ + P CGN ++ E C
Sbjct: 346 MNPEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEIC 405
Query: 429 DCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTS-ECDVPEYCN 487
DCGT +C CC+ TC LK A+C G CCKDC+ L G CR K ECD+ E CN
Sbjct: 406 DCGTEAQCGPASCCDFRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCN 465
Query: 488 GSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKG 547
GSS C PD+ + NG C+NNK CY+G C DA+C+ +FG ++ AP C+ E+ S+
Sbjct: 466 GSSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQS 525
Query: 548 DRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCWGVDFQ 606
DRFGNCG N+Y C N +CG+L C P +I R + C VD++
Sbjct: 526 DRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYK 585
Query: 607 LGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDV-QKKCHGHGVCNSNKNCHCE 665
L VPDP V G++C G++C N +CV++ ++ V ++C GHGVC+S CHC
Sbjct: 586 LPRTVPDPLAVKNGSQCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCS 645
Query: 666 NGWAPPNCETKGYGGSV----DSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRD 721
G+ PPNC+ + G S+ D G + + L+ F + +P+++ I + R
Sbjct: 646 PGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARK 705
Query: 722 QLWRSYFRKKR---SQTYESDGKNQ--ANPSRQPGSVPRHVS 758
QL + +F K+ S +S+G Q A+ S GS + S
Sbjct: 706 QL-KKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYAS 746
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 452 bits (1162), Expect = e-127
Identities = 249/702 (35%), Positives = 380/702 (54%), Gaps = 48/702 (6%)
Query: 65 QVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVH 124
Q SY I EGK + ++L + K+ LP +F VY+Y+ G + + QN CHY+GY+EG
Sbjct: 44 QASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYP 102
Query: 125 NSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEK 184
S + +S C GLRG+L EN SYGIEPL++S FEH+IY++ D+
Sbjct: 103 KSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKH----------KKADVSL 152
Query: 185 ETAKDEEEEPPSMTQLLRRRRAVLPQ---TRYVELFIVVDKERYDMMGRNQTAVREEMIL 241
KD E S + ++V PQ +Y+E+ ++V+K+ Y+ MG + T V +++
Sbjct: 153 YNEKDIESRDLSF-----KLQSVEPQQDFAKYIEMHVIVEKQLYNHMGSDTTVVAQKVFQ 207
Query: 242 LANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSA 301
L +++++ NI I+L LE+W + N I G A ++L F++W+ +L+ R HD A
Sbjct: 208 LIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRP-HDVA 266
Query: 302 QLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQ-ITVETFASIVAHELGHNLGMNHDDG 360
L++ + G F G +C ++AGG+ + + I++E+ A I+A L ++G+ +DD
Sbjct: 267 FLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDI 326
Query: 361 RDCSCGAKSCIMNSGA---SGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPS- 416
C C CIMN A SG + FS+CS EDF + CL N P+ D + +
Sbjct: 327 NKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAV 386
Query: 417 CGNKLVDAGEECDCGTPKECEL--DPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCR 474
CGN ++AGEECDCGT ++C L + CC+ +TC+ K+ + CA G CC++C F+ +CR
Sbjct: 387 CGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCR 446
Query: 475 GKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKA 534
ECD+PEYCNGSS C + ++Q G+PC N+ C +G+C D QC FG + +
Sbjct: 447 PSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEF 506
Query: 535 APKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTP 594
P +C+ +NSK D GNCG S + Y +C N CGKL C+ V + + II
Sbjct: 507 GPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYAN 566
Query: 595 SRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654
G C V+F + +GT CG+ K+CRN +CV +S L YDC KC+ G
Sbjct: 567 ISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTD-KCNDRG 625
Query: 655 VCNSNKNCHCENGWAPPNCETKG---YGGSVDSG-----------PTYNEMNTALRDGLL 700
VCN+ K+CHC + PP+C + GGS+DSG P + +
Sbjct: 626 VCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPM 685
Query: 701 VF-FFLIVP--LIVCAIFIFIKRDQLWRSYFRKKRSQTYESD 739
+ FFL +P +I C + + + R +K R++ Y SD
Sbjct: 686 RWPFFLFIPFFIIFCVLIAIMVKVNFQR---KKWRTEDYSSD 724
>gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
Length = 739
Score = 443 bits (1139), Expect = e-124
Identities = 250/688 (36%), Positives = 371/688 (53%), Gaps = 31/688 (4%)
Query: 64 KQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGV 123
+++ Y+I +G+ + +HL + + LP++F+VYTYN+ G+L + P HCHY+GY
Sbjct: 43 RKMIYIITIDGQPYTLHLGK-QSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEF 101
Query: 124 HNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIE 183
NS + LS C GLRG L EN SYGIEP+++S+ FEHIIY+M + V+ I
Sbjct: 102 PNSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIW 161
Query: 184 KETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLA 243
+ KD+ + P +Q+ + +LPQ Y+E++I+V+K YD MG AV ++++ +
Sbjct: 162 Q---KDQPYKVPLNSQI-KNLSKLLPQ--YLEIYIIVEKALYDYMGSEMMAVTQKIVQVI 215
Query: 244 NYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQL 303
+++M+ + ++L LE+W+N N I+ G A D+L F+ W+ +LI R HD A L
Sbjct: 216 GLVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRP-HDIAYL 274
Query: 304 VLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQ-ITVETFASIVAHELGHNLGMNHDDGRD 362
++ + G F GTVC++S+ GI ++ I +E F+ I+A LG N+G+ +DD
Sbjct: 275 LVYRKHPKYVGATFPGTVCNKSYDAGIAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQ 334
Query: 363 CSCGAKSCIMNS---GASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAY-SAPSCG 418
C C +CIMN ASG + FS+CS D+ CL + + + P CG
Sbjct: 335 CFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCG 394
Query: 419 NKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKD-CRFLPGGTLCRGKT 477
N ++++ EECDCG EC+ CC+ +TCKLK +C G CC C GT CR
Sbjct: 395 NGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSI 454
Query: 478 S-ECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAP 536
ECD EYCNG+S C PD + NG C+ AYCYNG CQ D QC IFG A+ AP
Sbjct: 455 DPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAP 514
Query: 537 KDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQC----ENVQEIPVFGIVPAIIQ 592
CF EVNS +R NCGF ++ C + LCGKL C +N + V + IQ
Sbjct: 515 FACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQ 574
Query: 593 TPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHG 652
+ G + SD D V +GT CG C N C ++ Y+C+ KC G
Sbjct: 575 DHVCVSIATGSSMR--SDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKG 632
Query: 653 HGVCNSNKNCHCENGWAPPNCETK--GYGGSVD------SGPTYNE--MNTALRDGLLVF 702
G+CN+ NC C G PP+C+ + GGS+D SG Y E NT + ++
Sbjct: 633 KGICNNFGNCQCFPGHRPPDCKFQFGSPGGSIDDGNFQKSGDFYTEKGYNTHWNNWFILS 692
Query: 703 FFLIVPLIVCAIFIFIKRDQLWRSYFRK 730
F + +P + + KR+++ +S R+
Sbjct: 693 FCIFLPFFIVFTTVIFKRNEISKSCNRE 720
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 431 bits (1107), Expect = e-120
Identities = 267/795 (33%), Positives = 400/795 (50%), Gaps = 76/795 (9%)
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
++ +G HI+ L +N++L+P + Y +GT + + +C Y+G V G S ++
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 130 LSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAK 188
+ C GLRGL+ L SY +E II R+ D++ C +S ++
Sbjct: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE---SVHT 189
Query: 189 DEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDS 248
+ E P + +RRRR V+ +T+ VEL IV D R+ + + +A LD+
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDT 248
Query: 249 MYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKG 308
+ LN+R+ LVGLE WT +L+ I L NF+ WR L+ R HDSAQLV
Sbjct: 249 FFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTS 308
Query: 309 FGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSCG 366
F G T GMA ++CS +GG+N+ ++ AS +AHELGH+LG++HD G C C
Sbjct: 309 FSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368
Query: 367 ----AKSCIMNSGAS--GSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
AK+CIM + NFS+CS EK L+ G+CL P A CGN
Sbjct: 369 GPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFCGNM 427
Query: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAY-GDCCKDCRFLPGGTLCRGKTSE 479
V+ GE+CDCG +C +DPCC+ TC+L+ A+CA G CC++C+ P G CR +
Sbjct: 428 FVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD 486
Query: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
CD+PE+C G S C PDV + +G PC +A C +G C Y QCQ ++G A+ A C
Sbjct: 487 CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLC 546
Query: 540 FIEVNSKGDRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAI----IQTP 594
N++G+ FG+CG + Y C +A+CG+LQC+ + P+ G + + I
Sbjct: 547 LQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVN 606
Query: 595 SRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654
C V LGSDV P + GT CG G +C + +C +L + + KCHGHG
Sbjct: 607 GTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECRSKCHGHG 665
Query: 655 VCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAI 714
VC+SN++C+CE GWAPP+C T+ + ++L GLL+ +++ L++
Sbjct: 666 VCDSNRHCYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGA 713
Query: 715 FIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHV------------SPVTP 762
+ + R K + Y + Q+ PS +PG R + P P
Sbjct: 714 SYWYRARLHQRLCQLKGPTCQYRA---AQSGPSERPGPPQRALLARGTKQASALSFPAPP 770
Query: 763 PREVPIYANRFAVPTYAAKQPQ-QFPSRPPPPQPKVSS--QGN----------------L 803
R +P P +K+ Q Q P++PPPP+ + + QG +
Sbjct: 771 SRPLP--------PDPVSKRLQSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLV 822
Query: 804 IPARPAPAPPLYSSL 818
+P+RPAP PP SSL
Sbjct: 823 VPSRPAPPPPTVSSL 837
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 429 bits (1103), Expect = e-120
Identities = 266/793 (33%), Positives = 399/793 (50%), Gaps = 73/793 (9%)
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
++ +G HI+ L +N++L+P + Y +GT + + +C Y+G V G S ++
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 130 LSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAK 188
+ C GLRGL+ L SY +E II R+ D++ C +S ++
Sbjct: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE---SVHT 189
Query: 189 DEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDS 248
+ E P + +RRRR V+ +T+ VEL IV D R+ + + +A LD+
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDT 248
Query: 249 MYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKG 308
+ LN+R+ LVGLE WT +L+ I L NF+ WR L+ R HDSAQLV
Sbjct: 249 FFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTS 308
Query: 309 FGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSCG 366
F G T GMA ++CS +GG+N+ ++ AS +AHELGH+LG++HD G C C
Sbjct: 309 FSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368
Query: 367 ----AKSCIMNSGAS--GSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
AK+CIM + NFS+CS EK L+ G+CL P A CGN
Sbjct: 369 GPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFCGNM 427
Query: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAY-GDCCKDCRFLPGGTLCRGKTSE 479
V+ GE+CDCG +C +DPCC+ TC+L+ A+CA G CC++C+ P G CR +
Sbjct: 428 FVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD 486
Query: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
CD+PE+C G S C PDV + +G PC +A C +G C Y QCQ ++G A+ A C
Sbjct: 487 CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLC 546
Query: 540 FIEVNSKGDRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAI----IQTP 594
N++G+ FG+CG + Y C +A+CG+LQC+ + P+ G + + I
Sbjct: 547 LQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVN 606
Query: 595 SRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654
C V LGSDV P + GT CG G +C + +C +L + + KCHGHG
Sbjct: 607 GTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECRSKCHGHG 665
Query: 655 VCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAI 714
VC+SN++C+CE GWAPP+C T+ + ++L GLL+ +++ L++
Sbjct: 666 VCDSNRHCYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGA 713
Query: 715 FIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHV-----------SPVTPP 763
+ + R K + Y + Q+ PS +PG R + P P
Sbjct: 714 SYWYRARLHQRLCQLKGPTCQYRA---AQSGPSERPGPPQRALLARGTKAELADRPNPPT 770
Query: 764 REVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSS--QGN----------------LIP 805
R +P A P + + Q P++PPPP+ + + QG ++P
Sbjct: 771 RPLP------ADPVVRSPK-SQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVP 823
Query: 806 ARPAPAPPLYSSL 818
+RPAP PP SSL
Sbjct: 824 SRPAPPPPTVSSL 836
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 427 bits (1098), Expect = e-119
Identities = 263/782 (33%), Positives = 396/782 (50%), Gaps = 75/782 (9%)
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
++ +G HI+ L +N++L+P + Y +GT + + +C Y+G V G S ++
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 130 LSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAK 188
+ C GLRGL+ L SY +E II R+ D++ C +S ++
Sbjct: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE---SVHT 189
Query: 189 DEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDS 248
+ E P + +RRRR V+ +T+ VEL IV D R+ + + +A LD+
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDT 248
Query: 249 MYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKG 308
+ LN+R+ LVGLE WT +L+ I L NF+ WR L+ R HDSAQLV
Sbjct: 249 FFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTS 308
Query: 309 FGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSCG 366
F G T GMA ++CS +GG+N+ ++ AS +AHELGH+LG++HD G C C
Sbjct: 309 FSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368
Query: 367 ----AKSCIMNSGAS--GSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
AK+CIM + NFS+CS EK L+ G+CL P A CGN
Sbjct: 369 GPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFCGNM 427
Query: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAY-GDCCKDCRFLPGGTLCRGKTSE 479
V+ GE+CDCG +C +DPCC+ TC+L+ A+CA G CC++C+ P G CR +
Sbjct: 428 FVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD 486
Query: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
CD+PE+C G S C PDV + +G PC +A C +G C Y QCQ ++G A+ A C
Sbjct: 487 CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLC 546
Query: 540 FIEVNSKGDRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAII--QTPSR 596
N++G+ FG+CG + Y C +A+CG+LQC+ + P+ G + ++
Sbjct: 547 LQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVN 606
Query: 597 GTK--CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654
GT+ C V LGSDV P + GT CG G +C + +C +L + + KCHGHG
Sbjct: 607 GTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECRSKCHGHG 665
Query: 655 VCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAI 714
VC+SN++C+CE GWAPP+C T+ + ++L GLL+ +++ L++
Sbjct: 666 VCDSNRHCYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGA 713
Query: 715 FIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFA 774
+ + R K + Y + Q+ PS +PG PP+ +
Sbjct: 714 SYWYRARLHQRLCQLKGPTCQYRAA---QSGPSERPG----------PPQRALL------ 754
Query: 775 VPTYAAKQPQQFPSRPPPPQPKVSS--QGN----------------LIPARPAPAPPLYS 816
A Q P++PPPP+ + + QG ++P+RPAP PP S
Sbjct: 755 ----ARGTKSQGPAKPPPPRKPLPADPQGRCPSGDLPGPGAGIPPLVVPSRPAPPPPTVS 810
Query: 817 SL 818
SL
Sbjct: 811 SL 812
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 426 bits (1095), Expect = e-119
Identities = 269/810 (33%), Positives = 403/810 (49%), Gaps = 83/810 (10%)
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
++ +G HI+ L +N++L+P + Y +GT + + +C Y+G V G S ++
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 130 LSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAK 188
+ C GLRGL+ L SY +E II R+ D++ C +S ++
Sbjct: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE---SVHT 189
Query: 189 DEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDS 248
+ E P + +RRRR V+ +T+ VEL IV D R+ + + +A LD+
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDT 248
Query: 249 MYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKG 308
+ LN+R+ LVGLE WT +L+ I L NF+ WR L+ R HDSAQLV
Sbjct: 249 FFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTS 308
Query: 309 FGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSCG 366
F G T GMA ++CS +GG+N+ ++ AS +AHELGH+LG++HD G C C
Sbjct: 309 FSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368
Query: 367 ----AKSCIMNSGAS--GSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
AK+CIM + NFS+CS EK L+ G+CL P A CGN
Sbjct: 369 GPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFCGNM 427
Query: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAY-GDCCKDCRFLPGGTLCRGKTSE 479
V+ GE+CDCG +C +DPCC+ TC+L+ A+CA G CC++C+ P G CR +
Sbjct: 428 FVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD 486
Query: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
CD+PE+C G S C PDV + +G PC +A C +G C Y QCQ ++G A+ A C
Sbjct: 487 CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLC 546
Query: 540 FIEVNSKGDRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAI----IQTP 594
N++G+ FG+CG + Y C +A+CG+LQC+ + P+ G + + I
Sbjct: 547 LQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVN 606
Query: 595 SRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654
C V LGSDV P + GT CG G +C + +C +L + + KCHGHG
Sbjct: 607 GTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECRSKCHGHG 665
Query: 655 VCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAI 714
VC+SN++C+CE GWAPP+C T+ + ++L GLL+ +++ L++
Sbjct: 666 VCDSNRHCYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGA 713
Query: 715 FIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHV-----------SPVTPP 763
+ + R K + Y + Q+ PS +PG R + P P
Sbjct: 714 SYWYRARLHQRLCQLKGPTCQYRA---AQSGPSERPGPPQRALLARGTKASALSFPAPPS 770
Query: 764 REVP----------IYANRFAVPTY------AAKQPQ-QFPSRPPPPQPKVSS--QGN-- 802
R +P A+R PT + P+ Q P++PPPP+ + + QG
Sbjct: 771 RPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRCP 830
Query: 803 --------------LIPARPAPAPPLYSSL 818
++P+RPAP PP SSL
Sbjct: 831 SGDLPGPGAGIPPLVVPSRPAPPPPTVSSL 860
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 426 bits (1094), Expect = e-119
Identities = 269/811 (33%), Positives = 403/811 (49%), Gaps = 84/811 (10%)
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
++ +G HI+ L +N++L+P + Y +GT + + +C Y+G V G S ++
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 130 LSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAK 188
+ C GLRGL+ L SY +E II R+ D++ C +S ++
Sbjct: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE---SVHT 189
Query: 189 DEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDS 248
+ E P + +RRRR V+ +T+ VEL IV D R+ + + +A LD+
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDT 248
Query: 249 MYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKG 308
+ LN+R+ LVGLE WT +L+ I L NF+ WR L+ R HDSAQLV
Sbjct: 249 FFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTS 308
Query: 309 FGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSCG 366
F G T GMA ++CS +GG+N+ ++ AS +AHELGH+LG++HD G C C
Sbjct: 309 FSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368
Query: 367 ----AKSCIMNSGAS--GSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
AK+CIM + NFS+CS EK L+ G+CL P A CGN
Sbjct: 369 GPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFCGNM 427
Query: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAY-GDCCKDCRFLPGGTLCRGKTSE 479
V+ GE+CDCG +C +DPCC+ TC+L+ A+CA G CC++C+ P G CR +
Sbjct: 428 FVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD 486
Query: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
CD+PE+C G S C PDV + +G PC +A C +G C Y QCQ ++G A+ A C
Sbjct: 487 CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLC 546
Query: 540 FIEVNSKGDRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAI----IQTP 594
N++G+ FG+CG + Y C +A+CG+LQC+ + P+ G + + I
Sbjct: 547 LQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVN 606
Query: 595 SRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654
C V LGSDV P + GT CG G +C + +C +L + + KCHGHG
Sbjct: 607 GTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECRSKCHGHG 665
Query: 655 VCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAI 714
VC+SN++C+CE GWAPP+C T+ + ++L GLL+ +++ L++
Sbjct: 666 VCDSNRHCYCEEGWAPPDCTTQ------------LKATSSLTTGLLLSLLVLLVLVMLGA 713
Query: 715 FIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHV------------SPVTP 762
+ + R K + Y + Q+ PS +PG R + P P
Sbjct: 714 SYWYRARLHQRLCQLKGPTCQYRA---AQSGPSERPGPPQRALLARGTKQASALSFPAPP 770
Query: 763 PREVP----------IYANRFAVPTY------AAKQPQ-QFPSRPPPPQPKVSS--QGN- 802
R +P A+R PT + P+ Q P++PPPP+ + + QG
Sbjct: 771 SRPLPPDPVSKRLQAELADRPNPPTRPLPADPVVRSPKSQGPAKPPPPRKPLPADPQGRC 830
Query: 803 ---------------LIPARPAPAPPLYSSL 818
++P+RPAP PP SSL
Sbjct: 831 PSGDLPGPGAGIPPLVVPSRPAPPPPTVSSL 861
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 420 bits (1079), Expect = e-117
Identities = 261/720 (36%), Positives = 370/720 (51%), Gaps = 46/720 (6%)
Query: 17 LLLLGLVGPVLGAAR-----PGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQ 71
LLLL L+ PV GA PG T H PWR +P V+ ++
Sbjct: 16 LLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDG--QPWRTVSLEEPVSKPDMGLVA--LE 71
Query: 72 AEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALS 131
AEG+E ++ LE+N LL ++ Y +G + PN +HCHY+G V G +S + L
Sbjct: 72 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLC 131
Query: 132 DCFGLRGLLHLE-NASYGIEPL--QNSSHFE-HIIYRMDDVYKEPLKCGVSNKDIEKETA 187
C G+ GL+ L NASY + P + S F H I+RM+ + CG ++D +
Sbjct: 132 TCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG--HRDPGNKAG 189
Query: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
P R RR +Y+EL+IV D + RN ++ ++ +ANY+D
Sbjct: 190 MTSLPGGPQS----RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVD 245
Query: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
+ L+I++ L GLE+WT + + A L F+QWR + L +R HDSAQL+ +
Sbjct: 246 QLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTGR 304
Query: 308 GF-GGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSC 365
F G T G+A V +C +GG++ A+ +AHE+GH+LG++HD DG
Sbjct: 305 AFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEA 364
Query: 366 GAKS--CIMNS--GASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKL 421
A+S C+M + G R FS+CS GG CL N P P CGN
Sbjct: 365 AAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGF 424
Query: 422 VDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECD 481
V+AGEECDCG +EC D CC C L+ A+CA+GDCC C P G LCR +CD
Sbjct: 425 VEAGEECDCGPGQECR-DLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCD 483
Query: 482 VPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFI 541
+PE+C G+S C PDV++ +G PC YC++G C + QCQ ++G + AP+ CF
Sbjct: 484 LPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQ 543
Query: 542 EVNSKGDRFGNCG-FSGNEYKKCATGNALCGKLQCENVQE---IPVFGIVPAIIQTPSRG 597
VNS GD GNCG S + CA +ALCGKLQC+ + P V + + +
Sbjct: 544 VVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQE 603
Query: 598 TKCWGV----DFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQK---KC 650
C G QL D+ G+V GT+CG +C++ +C N ++Q+ C
Sbjct: 604 VTCRGALALPSAQL--DLLGLGLVEPGTQCGPRMVCQSRRCRK----NAFQELQRCLTAC 657
Query: 651 HGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLI 710
H HGVCNSN NCHC GWAPP C+ G+GGS+DSGP E + L + +++PL+
Sbjct: 658 HSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFL--LAMLLSVLLPLL 715
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 410 bits (1055), Expect = e-114
Identities = 250/784 (31%), Positives = 379/784 (48%), Gaps = 72/784 (9%)
Query: 18 LLLGL--VGPVLGAARPGFQQTSHLSSYEIITPWRL-TRERREAPRP-----YSKQVSYV 69
+L GL V +L A ++ + YE++ P RL +REA P + ++ Y
Sbjct: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
+ GK +++L++NK+LL + YN G IT P I + C+Y+G++ S +
Sbjct: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
Query: 130 LSDCFGLRGLLHLENASYGIEPLQ--NSSHFEHIIYRMD-DVYKEPLKCGVSN----KDI 182
+S C GLRG + Y IEPL + EH +++ + D CG+ D+
Sbjct: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
Query: 183 EKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILL 242
++ A P+ + + R V +Y+E ++V+D + NQ +R+ + +
Sbjct: 181 QQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEM 234
Query: 243 ANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQ 302
ANY++ +Y LN + LVG+EIWT+ + I I A L NF +WR L R+RHD AQ
Sbjct: 235 ANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQ 294
Query: 303 LVLKKGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGR 361
L+ GT G+AF+ T+CS G + + A +AHE+GHN GM HDD
Sbjct: 295 LITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRV-AGTMAHEMGHNFGMFHDD-Y 352
Query: 362 DCSCGAKSCIMNSGASG--SRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGN 419
C C + C+M+ S +FSSCS ++K +K NCL N P P + S P CGN
Sbjct: 353 SCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGN 412
Query: 420 KLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE 479
+LV+ GE+CDCGT +EC + CC+ TCK+K+ +CA G+CC+ C+F G +CR E
Sbjct: 413 QLVEMGEDCDCGTSEECT-NICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDE 471
Query: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
CD+PE CNG S C D F NG+PC + K +C G C QC ++G + A K C
Sbjct: 472 CDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSC 531
Query: 540 FIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQE-IPVFGIVPAIIQTPSRGT 598
+ N G ++G C + C + +CGKL C+ + +P G + + +
Sbjct: 532 Y-NRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKT--- 587
Query: 599 KCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNS 658
F + GMV GTKCG K+C N +CVD + KC GH VC+
Sbjct: 588 ------FDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDH 641
Query: 659 NKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIV-----PL-IVC 712
C CE GW PP+C+ D +VF F IV P+ ++
Sbjct: 642 ELQCQCEEGWIPPDCD----------------------DSSVVFHFSIVVGVLFPMAVIF 679
Query: 713 AIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSV----PRHVSPVTP-PREVP 767
+ + R Q R +KK + + G R+P V P+ +S + P ++P
Sbjct: 680 VVVAMVIRHQSSREK-QKKDQRPLSTTGTRPHKQKRKPQMVKAVQPQEMSQMKPHVYDLP 738
Query: 768 IYAN 771
+ N
Sbjct: 739 VEGN 742
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 410 bits (1054), Expect = e-114
Identities = 235/653 (35%), Positives = 344/653 (52%), Gaps = 30/653 (4%)
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
++ +G HI+ L +N++L+P + Y +GT + + +C Y+G V G S ++
Sbjct: 73 LELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVS 132
Query: 130 LSDCFGLRGLLHLE-NASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAK 188
+ C GLRGL+ L SY +E II R+ D++ C +S ++
Sbjct: 133 ICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRE---SVHT 189
Query: 189 DEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDS 248
+ E P + +RRRR V+ +T+ VEL IV D R+ + + +A LD+
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDT 248
Query: 249 MYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKG 308
+ LN+R+ LVGLE WT +L+ I L NF+ WR L+ R HDSAQLV
Sbjct: 249 FFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTS 308
Query: 309 FGG-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSCG 366
F G T GMA ++CS +GG+N+ ++ AS +AHELGH+LG++HD G C C
Sbjct: 309 FSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCP 368
Query: 367 ----AKSCIMNSGAS--GSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK 420
AK+CIM + NFS+CS EK L+ G+CL P A CGN
Sbjct: 369 GPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFCGNM 427
Query: 421 LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAY-GDCCKDCRFLPGGTLCRGKTSE 479
V+ GE+CDCG +C +DPCC+ TC+L+ A+CA G CC++C+ P G CR +
Sbjct: 428 FVEPGEQCDCGFLDDC-VDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGD 486
Query: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
CD+PE+C G S C PDV + +G PC +A C +G C Y QCQ ++G A+ A C
Sbjct: 487 CDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLC 546
Query: 540 FIEVNSKGDRFGNCGFS-GNEYKKCATGNALCGKLQCENVQEIPVFGIVPAI----IQTP 594
N++G+ FG+CG + Y C +A+CG+LQC+ + P+ G + + I
Sbjct: 547 LQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVN 606
Query: 595 SRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654
C V LGSDV P + GT CG G +C + +C +L + + KCHGHG
Sbjct: 607 GTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQ-ECRSKCHGHG 665
Query: 655 VCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIV 707
VC+SN++C+CE GWAPP+C T+ S + T L LLV L++
Sbjct: 666 VCDSNRHCYCEEGWAPPDCTTQLKATS--------SLTTGLLLSLLVLLVLVM 710
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 400 bits (1027), Expect = e-111
Identities = 271/847 (31%), Positives = 395/847 (46%), Gaps = 109/847 (12%)
Query: 18 LLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRL--TRERREAPRP---YSKQVSYVIQA 72
LL ++ P + +RP + + YE++ PWRL R RR P + ++VSYV+ A
Sbjct: 8 LLGAMMLPAIAPSRPW----ALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGA 63
Query: 73 EGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSD 132
G +HL +N+DLL + G+ +T+ P Q+HC Y+G+VEG +S+ +LS
Sbjct: 64 TGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLST 123
Query: 133 CFGLRGLLHLENASYGIEPL-QNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEE 191
C GLRG + + + IEPL + H +Y+ + + + CGVS+ +
Sbjct: 124 CAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLG---- 179
Query: 192 EEPPSMTQLLRRRRAVLP--QTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSM 249
P + R LP +TRYVEL++VVD + M+G ++ AVR ++ + N++D +
Sbjct: 180 --PRTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLG-SEAAVRHRVLEVVNHVDKL 236
Query: 250 YIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGF 309
Y LN R+VLVGLEIW + + ++ L N + W+ + R HD+ QL+ F
Sbjct: 237 YQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDF 296
Query: 310 -GGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDG-RDCSC-- 365
G T G A V +CS S +G +N A +AHE+GHNLGM+HD+ + C C
Sbjct: 297 TGTTVGFARVSAMCSHS-SGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQE 355
Query: 366 --GAKSCIM--NSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKL 421
A CIM + G+S R FS CS E CL N P P CGN
Sbjct: 356 RFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLF 415
Query: 422 VDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECD 481
V+ GE+CDCG P++C + CC +TC+L A+CA+G CC++C+ P G LCR K CD
Sbjct: 416 VERGEQCDCGPPEDCR-NRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCD 474
Query: 482 VPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFI 541
+ E+C+G C D F +NG PC YCYNG C QCQ +G +AA + CF
Sbjct: 475 LEEFCDGRHPECPEDAFQENGTPCSG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCF- 531
Query: 542 EVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKCW 601
D C + Y+ +CG LQC+ Q+ G I+ T
Sbjct: 532 ----SYDILPGC--KASRYRA-----DMCGVLQCKGGQQ--PLGRAICIVDVCHALTTED 578
Query: 602 GVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVL-NYDCDVQKKCHGHGVCNSNK 660
G ++ V EGT+CG K+C +C D V + +C Q CH HGVCN +
Sbjct: 579 GTAYE---------PVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQ--CHNHGVCNHKQ 627
Query: 661 NCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKR 720
CHC GWAPP+C E++ A G L F ++V +++ + + +
Sbjct: 628 ECHCHAGWAPPHC-----------AKLLTEVHAA--SGSLPVFVVVVLVLLAVVLVTLAG 674
Query: 721 DQLWR----------------------------SYFRKKRSQTYESDGKNQANPSRQPGS 752
++R S K S G + P+ PG
Sbjct: 675 IIVYRKARSRILSRNVAPKTTMGRSNPLFHQAASRVPAKGGAPAPSRGPQELVPTTHPGQ 734
Query: 753 VPRH----VSPVTPPREVPIYANR--FAVPTYAAKQPQQF--PSRPPPPQPKVSSQGNLI 804
RH V+ PP P+ + F VP Y + P+Q P+ PP P G
Sbjct: 735 PARHPASSVALKRPPPAPPVTVSSPPFPVPVYTRQAPKQVIKPTFAPPVPPVKPGAG--- 791
Query: 805 PARPAPA 811
A P PA
Sbjct: 792 AANPGPA 798
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 395 bits (1015), Expect = e-110
Identities = 253/717 (35%), Positives = 355/717 (49%), Gaps = 66/717 (9%)
Query: 17 LLLLGLVGPVLGAAR-----PGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQ 71
LLLL L+ PV GA PG T H PWR +P V+ ++
Sbjct: 16 LLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDG--QPWRTVSLEEPVSKPDMGLVA--LE 71
Query: 72 AEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALS 131
AEG+E ++ LE+N LL ++ Y +G + PN +HCHY+G V G +S + L
Sbjct: 72 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLC 131
Query: 132 DCFGLRGLLHLE-NASYGIEPL--QNSSHFE-HIIYRMDDVYKEPLKCGVSNKDIEKETA 187
C G+ GL+ L NASY + P + S F H I+RM+ + CG ++D +
Sbjct: 132 TCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG--HRDPGNKAG 189
Query: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
P R RR +Y+EL+IV D + RN ++ ++ +ANY+D
Sbjct: 190 MTSLPGGPQS----RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVD 245
Query: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
+ L+I++ L GLE+WT + + A L F+QWR + L +R HDSAQL+ +
Sbjct: 246 QLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTGR 304
Query: 308 GF-GGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSC 365
F G T G+A V +C +GG++ A+ +AHE+GH+LG++HD DG
Sbjct: 305 AFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEA 364
Query: 366 GAKS--CIMNS--GASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKL 421
A+S C+M + G R FS+CS GG CL N P P CGN
Sbjct: 365 AAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGF 424
Query: 422 VDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECD 481
V+AGEECDCG +EC D CC C L+ A+CA+GDCC C P G LCR +CD
Sbjct: 425 VEAGEECDCGPGQECR-DLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCD 483
Query: 482 VPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFI 541
+PE+C G+S C PDV++ +G PC YC++G C + QCQ ++G + AP+ CF
Sbjct: 484 LPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQ 543
Query: 542 EVNSKGDRFGNCG-FSGNEYKKCATGNALCGKLQCENVQE---IPVFGIVPAIIQTPSRG 597
VNS GD GNCG S + CA +ALCGKLQC+ + P V + + +
Sbjct: 544 VVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQE 603
Query: 598 TKCWGV----DFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGH 653
C G QL D+ G+V GT+CG
Sbjct: 604 VTCRGALALPSAQL--DLLGLGLVEPGTQCGP---------------------------R 634
Query: 654 GVCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLI 710
VCNSN NCHC GWAPP C+ G+GGS+DSGP E + L + +++PL+
Sbjct: 635 MVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFL--LAMLLSVLLPLL 689
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 366 bits (939), Expect = e-101
Identities = 200/621 (32%), Positives = 316/621 (50%), Gaps = 18/621 (2%)
Query: 60 RPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGY 119
+ Y +++ Y I+ K ++HL R+++ L ++ Y+ +G T HP I +HC Y+G
Sbjct: 53 KTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGS 112
Query: 120 VEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSN 179
+ ++S+ ++S C GLRG + + Y IEP++ S EH++++ + + P S
Sbjct: 113 IVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYN--LRVPYGANYSC 170
Query: 180 KDIE---KETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVR 236
++ K D E E S + + +YVELFIV D Y G +R
Sbjct: 171 TELNFTRKTVPGDNESEEDSKIKGIH-------DEKYVELFIVADDTVYRRNGHPHNKLR 223
Query: 237 EEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRR 296
+ + N+++ +Y LNI + LVG+EIWT+ + I + L F W+EK L TR+
Sbjct: 224 NRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRK 283
Query: 297 RHDSAQLVLKKG-FGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGM 355
D L+ K + G+++ G +C ++ I A+ +AH+LGHNLGM
Sbjct: 284 DFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGM 343
Query: 356 NHDDGRDCSCGAKSCIMNS-GASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSA 414
HD+ C+C + C+M+S G+ + FS CS + + + C+LNIP P +
Sbjct: 344 QHDEF-PCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDF 402
Query: 415 PSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCR 474
CGNK +D GEECDCG +EC +PCC+ TC LK CA G+CC+ C+ G++CR
Sbjct: 403 QFCGNKKLDEGEECDCGPAQECT-NPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICR 461
Query: 475 GKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKA 534
ECD PE C G S C D F NG+PC+N++ YC+ G C + QC +F +A
Sbjct: 462 PAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIE 521
Query: 535 APKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAI-IQT 593
+ C+ ++N+KG++FG C N + C + CGK+ C + + G ++
Sbjct: 522 SHDICY-KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKD 580
Query: 594 PSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGH 653
P + L D D G+V GTKCG G +C N +C++ + + +C+ +
Sbjct: 581 PQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNEN 640
Query: 654 GVCNSNKNCHCENGWAPPNCE 674
V CHCE G AP CE
Sbjct: 641 PVDGHGLQCHCEEGQAPVACE 661
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 334 bits (856), Expect = 2e-91
Identities = 212/644 (32%), Positives = 314/644 (48%), Gaps = 54/644 (8%)
Query: 65 QVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVH 124
Q S+ I+A G + I+ L N LL D+V Y + HC+Y G + GV
Sbjct: 150 QASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKP---QYSKGGEHCYYHGSIRGVK 206
Query: 125 NSSIALSDCFGLRGLLHLENASYGIEPLQ-----NSSHFEHIIYRMDDVYKEPLKCGVSN 179
+S +ALS C GL G+ + Y IEPL+ S+ HII + G +
Sbjct: 207 DSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKT--------LAGQYS 258
Query: 180 KDIEKETAKDEEEEP--PSMTQLLRRRRAVLP------QTRYVELFIVVDKERYDMMGRN 231
K ++ T + ++ P + L RR+RAV P + +Y+EL IV D + Y +
Sbjct: 259 KQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSS 318
Query: 232 QTAVREEMILLANYLDSMYI-MLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREK 290
+ N +DS+Y LN R+VLV +E WT + I+I +L F ++R++
Sbjct: 319 HAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR 378
Query: 291 FLITRRRHDSAQLVLKKGFG-GTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHEL 349
++ D+ L+ + F + +++ G VCSR+ G+N +G A +++ L
Sbjct: 379 I---KQHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYG--LPMAVAQVLSQSL 433
Query: 350 GHNLGMNHDDGR-----DCSCGAKSCIMN-SGASGSRNFSSCSAEDFEKLTLNKGGNCLL 403
NLG+ + DC+ CIM +G S SR FS CS ++ GG CL
Sbjct: 434 AQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLF 493
Query: 404 NIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKD 463
N +P + + CGN V+AGEECDCG EC CC+ C L + A C+ G CC +
Sbjct: 494 N--RPTKLFEPTECGNGYVEAGEECDCGFHVEC-YGLCCK--KCSLSNGAHCSDGPCCNN 548
Query: 464 --CRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYD 521
C F P G CR +ECD+ EYC G S C P++ Q+GY C N+ CYNG C+ D
Sbjct: 549 TSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRD 608
Query: 522 AQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEI 581
QCQ I+G+KA + K C+ ++N++G GNCG G+ + +C+ + CG L C N+
Sbjct: 609 NQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRA 668
Query: 582 PVFG-----IVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVD 636
P G I+P R C G L D D G V +GT CG +C + +C+
Sbjct: 669 PRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDT-DVGYVEDGTPCGPSMMCLDRKCLQ 727
Query: 637 ASVLNY-DCDVQKK---CHGHGVCNSNKNCHCENGWAPPNCETK 676
LN C + K C GHGVC++ C C+ WA +C +
Sbjct: 728 IQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIR 771
>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
[Homo sapiens]
Length = 540
Score = 333 bits (855), Expect = 3e-91
Identities = 187/540 (34%), Positives = 281/540 (52%), Gaps = 27/540 (5%)
Query: 18 LLLGL--VGPVLGAARPGFQQTSHLSSYEIITPWRL-TRERREAPRP-----YSKQVSYV 69
+L GL V +L A ++ + YE++ P RL +REA P + ++ Y
Sbjct: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYK 60
Query: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIA 129
+ GK +++L++NK+LL + YN G IT P I + C+Y+G++ S +
Sbjct: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
Query: 130 LSDCFGLRGLLHLENASYGIEPLQ--NSSHFEHIIYRMD-DVYKEPLKCGVSN----KDI 182
+S C GLRG + Y IEPL + EH +++ + D CG+ D+
Sbjct: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDL 180
Query: 183 EKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILL 242
++ A P+ + + R V +Y+E ++V+D + NQ +R+ + +
Sbjct: 181 QQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEM 234
Query: 243 ANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQ 302
ANY++ +Y LN + LVG+EIWT+ + I I A L NF +WR L R+RHD AQ
Sbjct: 235 ANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQ 294
Query: 303 LVLKKGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGR 361
L+ GT G+AF+ T+CS G + + A +AHE+GHN GM HDD
Sbjct: 295 LITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRV-AGTMAHEMGHNFGMFHDD-Y 352
Query: 362 DCSCGAKSCIMNSGASG--SRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGN 419
C C + C+M+ S +FSSCS ++K +K NCL N P P + S P CGN
Sbjct: 353 SCKCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGN 412
Query: 420 KLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE 479
+LV+ GE+CDCGT +EC + CC+ TCK+K+ +CA G+CC+ C+F G +CR E
Sbjct: 413 QLVEMGEDCDCGTSEECT-NICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDE 471
Query: 480 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 539
CD+PE CNG S C D F NG+PC + K +C G C QC ++G + P C
Sbjct: 472 CDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPC 531
>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
Length = 769
Score = 333 bits (854), Expect = 4e-91
Identities = 236/733 (32%), Positives = 353/733 (48%), Gaps = 78/733 (10%)
Query: 2 GSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHL----SSYEIITPWRLTRERRE 57
G G + P+G LR L LG G P + S L S E+ TR R+E
Sbjct: 21 GLGTQGPAGALRWGGLPQLG------GPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQE 74
Query: 58 ---APRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPN-IQNH 113
P + QVS+VI A + LE N LL +V +++EGT T H +H
Sbjct: 75 PPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGT--TQHSTGAGDH 132
Query: 114 CHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHF-------EHIIYRMD 166
C+Y+G + G +S ALS C GL G+ N +Y +EP + + + H+IYR
Sbjct: 133 CYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTP 192
Query: 167 DVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRA------VLPQTRYVELFIVV 220
+ +PL C ++ A + PP+ +L R+R+ V +T+YVEL ++
Sbjct: 193 -LLPDPLGC----REPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVIN 247
Query: 221 DKERYDMMGRNQTAVREEMILLANYLDSMYI-MLNIRIVLVGLEIWTNGNLINIVGGAGD 279
D + ++ M ++ + N D +Y LN RIVLV +E W +G+ I + +
Sbjct: 248 DHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLE 307
Query: 280 VLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTA-GMAFVGTVCSRSHAGGINVFGQITV 338
L + +R + L D+ L + F T+ G A+VG +CS SH GG+N +G +
Sbjct: 308 TLARLMVYRREGL--PEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGA 365
Query: 339 ETFASIVAHELGHNLGMNHDDGR----DCSCGA--KSCIM-NSGASGSRNFSSCSAEDFE 391
A +A LG NLGM + R DC C CIM ++G R FS CS +++
Sbjct: 366 --MAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYN 423
Query: 392 KLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECEL--DPCCEGSTCKL 449
+ GG+CL N KP + P CGN V+AGEECDCG+ +EC CC+ C L
Sbjct: 424 QFLQEGGGSCLFN--KPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCK--KCTL 479
Query: 450 KSFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNK 509
A C+ G CC+ C++ P G CR +ECD+ E C G S C P++ +GY C + +
Sbjct: 480 THDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQ 539
Query: 510 AYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNAL 569
CY G C+ D QCQV++G AA + C+ ++N +G G+CG G+ + +C+ + L
Sbjct: 540 GRCYGGRCKTRDRQCQVLWGH--AAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVL 597
Query: 570 CGKLQCENVQEIPVFGIVPAIIQT-----PSRGTKCWGVDFQLGSDVPDPGMVNEGTKCG 624
CG L C N+ P G + I + + C G QL +D D V +GT CG
Sbjct: 598 CGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQL-ADGSDLSYVEDGTACG 656
Query: 625 AGKICRNFQCVDASVLNYD----CDVQKKCHGHGVCNSNKNCHCENGW------------ 668
+C + +C+ AS N+ ++ C HGVC++ C C+ W
Sbjct: 657 PNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLP 716
Query: 669 -APPNCETKGYGG 680
+PP ET+ Y G
Sbjct: 717 TSPPTGETERYKG 729
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 329 bits (843), Expect = 7e-90
Identities = 232/791 (29%), Positives = 368/791 (46%), Gaps = 68/791 (8%)
Query: 65 QVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVH 124
Q S+ + A G I+ + N DLL +++ G + HC+Y+G++ G
Sbjct: 88 QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
Query: 125 NSSIALSDCFGLRGLLHLENASYGIEPLQNSS-----HFEHIIYR-------MDDVYKEP 172
+S +ALS C GL G+ + N +Y IEP +N + HF H +Y+ +DD+ E
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHF-HSVYKSRLFEFSLDDLPSEF 204
Query: 173 LKCGVS-NKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVD-----KERYD 226
+ ++ +K I K K S QL R R V +T+Y+EL IV D K R
Sbjct: 205 QQVNITPSKFILKPRPKR------SKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLS 258
Query: 227 MMGRNQTAVREEMILLANYLDSMYI-MLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFV 285
++ N A + N D +Y L RIVLV +E W N I L F+
Sbjct: 259 VVHTNTYAKS-----VVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFM 313
Query: 286 QWREKFLITRRRHDSAQLVLKKGFGGT-AGMAFVGTVCSRSHAGGINVFGQITVETFASI 344
++R F+ + + D+ L F + +G A++G +CS GG+N FG+ + A
Sbjct: 314 KYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGK--TDLMAVT 369
Query: 345 VAHELGHNLGMNHDDGR----DCSCGA--KSCIM-NSGASGSRNFSSCSAEDFEKLTLNK 397
+A L HN+G+ D + +C C CIM ++G + F+ C+ E++ +
Sbjct: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSG 429
Query: 398 GGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELD--PCCEGSTCKLKSFAEC 455
GG CL N KP + P CGN ++ GEECDCGTP EC L+ CC+ C L ++C
Sbjct: 430 GGACLFN--KPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQC 485
Query: 456 AYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNG 515
+ G CCK C+F P GT+CR ++CD+ E C+G+S C P++ +GY C + C+ G
Sbjct: 486 SDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGG 545
Query: 516 MCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQC 575
C+ D QC+ I+G K A+ K C+ ++N +G GNCG + + +C + LCG L C
Sbjct: 546 RCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLC 605
Query: 576 ENVQEIPVFG-----IVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICR 630
N+ IP G I ++ R C G +L DV D G V +GT CG +C
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
Query: 631 NFQCVDASVLNYDCDVQKK----CHGHGVCNSNKNCHCENGWAPPNCETK-GYGGSVDSG 685
+C+ + N+ + K C G+GVC++ C C W +C T + +G
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTG 724
Query: 686 PTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQAN 745
T + A G + +I I+ I +++Y R++RS +
Sbjct: 725 ITLSGNGVA---GTNIIIGIIAGTILVLALILGITAWGYKNY-REQRSNGLSHSWSERIP 780
Query: 746 PSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIP 805
++ + + P + + + N+ + + P + SS G++
Sbjct: 781 DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSIAS 840
Query: 806 AR--PAPAPPL 814
+R P P PPL
Sbjct: 841 SRKYPYPMPPL 851
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 328 bits (842), Expect = 9e-90
Identities = 209/649 (32%), Positives = 319/649 (49%), Gaps = 61/649 (9%)
Query: 65 QVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVH 124
Q S+ + A G I+ + N DLL +++ G + HC+Y+G++ G
Sbjct: 88 QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
Query: 125 NSSIALSDCFGLRGLLHLENASYGIEPLQNSS-----HFEHIIYR-------MDDVYKEP 172
+S +ALS C GL G+ + N +Y IEP +N + HF H +Y+ +DD+ E
Sbjct: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHF-HSVYKSRLFEFSLDDLPSEF 204
Query: 173 LKCGVS-NKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVD-----KERYD 226
+ ++ +K I K K S QL R R V +T+Y+EL IV D K R
Sbjct: 205 QQVNITPSKFILKPRPKR------SKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLS 258
Query: 227 MMGRNQTAVREEMILLANYLDSMYI-MLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFV 285
++ N A + N D +Y L RIVLV +E W N I L F+
Sbjct: 259 VVHTNTYAKS-----VVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFM 313
Query: 286 QWREKFLITRRRHDSAQLVLKKGFGGT-AGMAFVGTVCSRSHAGGINVFGQITVETFASI 344
++R F+ + + D+ L F + +G A++G +CS GG+N FG+ + A
Sbjct: 314 KYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGK--TDLMAVT 369
Query: 345 VAHELGHNLGMNHDDGR----DCSCGA--KSCIM-NSGASGSRNFSSCSAEDFEKLTLNK 397
+A L HN+G+ D + +C C CIM ++G + F+ C+ E++ +
Sbjct: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSG 429
Query: 398 GGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELD--PCCEGSTCKLKSFAEC 455
GG CL N KP + P CGN ++ GEECDCGTP EC L+ CC+ C L ++C
Sbjct: 430 GGACLFN--KPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQC 485
Query: 456 AYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNG 515
+ G CCK C+F P GT+CR ++CD+ E C+G+S C P++ +GY C + C+ G
Sbjct: 486 SDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGG 545
Query: 516 MCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQC 575
C+ D QC+ I+G K A+ K C+ ++N +G GNCG + + +C + LCG L C
Sbjct: 546 RCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLC 605
Query: 576 ENVQEIPVFG-----IVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICR 630
N+ IP G I ++ R C G +L DV D G V +GT CG +C
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
Query: 631 NFQCVDASVLNYDCDVQKK----CHGHGVCNSNKNCHCENGWAPPNCET 675
+C+ + N+ + K C G+GVC++ C C W +C T
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNT 713
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,410,793
Number of Sequences: 37866
Number of extensions: 2032142
Number of successful extensions: 10631
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 134
Number of HSP's successfully gapped in prelim test: 304
Number of HSP's that attempted gapping in prelim test: 8421
Number of HSP's gapped (non-prelim): 1817
length of query: 819
length of database: 18,247,518
effective HSP length: 111
effective length of query: 708
effective length of database: 14,044,392
effective search space: 9943429536
effective search space used: 9943429536
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.