Search of human proteins with 31881779

Search of human proteins with 31881779

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31881779 GDP-mannose pyrophosphorylase A [Homo sapiens]
         (420 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31881779 GDP-mannose pyrophosphorylase A [Homo sapiens]            856   0.0  
gi|45447090 GDP-mannose pyrophosphorylase A [Homo sapiens]            856   0.0  
gi|11761621 GDP-mannose pyrophosphorylase B isoform 2 [Homo sapi...   201   8e-52
gi|11761619 GDP-mannose pyrophosphorylase B isoform 1 [Homo sapi...   200   2e-51
gi|83267879 eukaryotic translation initiation factor 2B, subunit...    41   0.002
gi|9966779 eukaryotic translation initiation factor 2B, subunit ...    36   0.075
gi|223972704 hypothetical protein LOC284418 [Homo sapiens]             32   1.4  
gi|105990532 apolipoprotein B precursor [Homo sapiens]                 30   3.1  
gi|170016069 zinc finger, CCHC domain containing 2 [Homo sapiens]      29   7.0  
gi|156151386 hypothetical protein LOC80157 [Homo sapiens]              29   9.1  

>gi|31881779 GDP-mannose pyrophosphorylase A [Homo sapiens]
          Length = 420

 Score =  856 bits (2211), Expect = 0.0
 Identities = 420/420 (100%), Positives = 420/420 (100%)

Query: 1   MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQ 60
           MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQ
Sbjct: 1   MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQ 60

Query: 61  PDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSD 120
           PDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSD
Sbjct: 61  PDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSD 120

Query: 121 FPLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIIN 180
           FPLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIIN
Sbjct: 121 FPLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIIN 180

Query: 181 CGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHL 240
           CGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHL
Sbjct: 181 CGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHL 240

Query: 241 TDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAV 300
           TDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAV
Sbjct: 241 TDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAV 300

Query: 301 LGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDP 360
           LGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDP
Sbjct: 301 LGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDP 360

Query: 361 NPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL 420
           NPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL
Sbjct: 361 NPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL 420


>gi|45447090 GDP-mannose pyrophosphorylase A [Homo sapiens]
          Length = 420

 Score =  856 bits (2211), Expect = 0.0
 Identities = 420/420 (100%), Positives = 420/420 (100%)

Query: 1   MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQ 60
           MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQ
Sbjct: 1   MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQ 60

Query: 61  PDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSD 120
           PDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSD
Sbjct: 61  PDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSD 120

Query: 121 FPLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIIN 180
           FPLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIIN
Sbjct: 121 FPLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIIN 180

Query: 181 CGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHL 240
           CGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHL
Sbjct: 181 CGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHL 240

Query: 241 TDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAV 300
           TDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAV
Sbjct: 241 TDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAV 300

Query: 301 LGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDP 360
           LGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDP
Sbjct: 301 LGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDP 360

Query: 361 NPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL 420
           NPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL
Sbjct: 361 NPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL 420


>gi|11761621 GDP-mannose pyrophosphorylase B isoform 2 [Homo
           sapiens]
          Length = 360

 Score =  201 bits (512), Expect = 8e-52
 Identities = 133/412 (32%), Positives = 199/412 (48%), Gaps = 60/412 (14%)

Query: 2   LKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQP 61
           +KA+IL+GG   GTR RPL+   PKPL      P++ H +EA A   G+  ++L   Y  
Sbjct: 1   MKALILVGG--YGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAA-GVDHVILAVSYM- 56

Query: 62  DEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDF 121
            + L + ++A +Q   + +    E  PLGT G L   RD +L+ + + FFVLN+DV  DF
Sbjct: 57  SQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARD-LLSETADPFFVLNSDVICDF 115

Query: 122 PLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINC 181
           P  AM++ HR       +L T         YG +V    T  +  +VEKP  F+S+ IN 
Sbjct: 116 PFQAMVQFHRHHGQEGSILVTKVEEPSK--YGVVVCEADTGRIHRFVEKPQVFVSNKINA 173

Query: 182 GIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLT 241
           G+Y+ SP  L+ +           QL+ +           +E++VF  +A +GQ+Y    
Sbjct: 174 GMYILSPAVLRRI-----------QLQPTS----------IEKEVFPIMAKEGQLYAMEL 212

Query: 242 DGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAVL 301
            G W  I      L    L+L   +   PERL      GP I GNV + P+A++  +  +
Sbjct: 213 QGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCS----GPGIVGNVLVDPSARIGQNCSI 268

Query: 302 GPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPN 361
           GPNVS+G GV V +GV +R   VL  A ++ H+ +   IVGW   VG+W R+E       
Sbjct: 269 GPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVRMEN------ 322

Query: 362 PNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRS 413
                                 +T+LG  V +  E+ +  + VLPHK +  S
Sbjct: 323 ----------------------VTVLGEDVIVNDELYLNGASVLPHKSIGES 352


>gi|11761619 GDP-mannose pyrophosphorylase B isoform 1 [Homo
           sapiens]
          Length = 387

 Score =  200 bits (508), Expect = 2e-51
 Identities = 132/412 (32%), Positives = 202/412 (49%), Gaps = 33/412 (8%)

Query: 2   LKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQP 61
           +KA+IL+GG   GTR RPL+   PKPL      P++ H +EA A   G+  ++L   Y  
Sbjct: 1   MKALILVGG--YGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAA-GVDHVILAVSYM- 56

Query: 62  DEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDF 121
            + L + ++A +Q   + +    E  PLGT G L   RD +L+ + + FFVLN+DV  DF
Sbjct: 57  SQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARD-LLSETADPFFVLNSDVICDF 115

Query: 122 PLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINC 181
           P  AM++ HR       +L T         YG +V    T  +  +VEKP  F+S+ IN 
Sbjct: 116 PFQAMVQFHRHHGQEGSILVTKVEEPSK--YGVVVCEADTGRIHRFVEKPQVFVSNKINA 173

Query: 182 GIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLT 241
           G+Y+ SP  L+ +           QL+ +           +E++VF  +A +GQ+Y    
Sbjct: 174 GMYILSPAVLRRI-----------QLQPTS----------IEKEVFPIMAKEGQLYAMEL 212

Query: 242 DGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAVL 301
            G W  I      L    L+L   +   PERL      GP I GNV + P+A++  +  +
Sbjct: 213 QGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCS----GPGIVGNVLVDPSARIGQNCSI 268

Query: 302 GPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPN 361
           GPNVS+G GV V +GV +R   VL  A ++ H+ +   IVGW   VG+W  +        
Sbjct: 269 GPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVSLWAGLGGER 328

Query: 362 PNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRS 413
             +     D      + + +  +T+LG  V +  E+ +  + VLPHK +  S
Sbjct: 329 GGECACLPDKAYPLLEVR-MENVTVLGEDVIVNDELYLNGASVLPHKSIGES 379


>gi|83267879 eukaryotic translation initiation factor 2B, subunit 5
           epsilon, 82kDa [Homo sapiens]
          Length = 721

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 80/420 (19%), Positives = 156/420 (37%), Gaps = 71/420 (16%)

Query: 16  RFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFY---QPDEPLTQFLEAA 72
           RF P+S + P+ L P+A V +I + +E      G+QE  +   +   Q  E L +     
Sbjct: 55  RFFPISKDQPRVLLPLANVALIDYTLEFLTAT-GVQETFVFCCWKAAQIKEHLLKSKWCR 113

Query: 73  QQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDFPLSAMLEAHRR 132
               N+ VR +        G  L     + L  S   F ++  DV S+  ++  LE HR 
Sbjct: 114 PTSLNV-VRIITSELYRSLGDVLRDVDAKALVRSD--FLLVYGDVISNINITRALEEHRL 170

Query: 133 QR----HPFLLLGTTANRTQSLNYGCIVEN------PQTHEVLHYVEK--------PSTF 174
           +R    +  ++       + S    C  +N        T+ VLH+ +         P + 
Sbjct: 171 RRKLEKNVSVMTMIFKESSPSHPTRCHEDNVVVAVDSTTNRVLHFQKTQGLRRFAFPLSL 230

Query: 175 IS----------DIINCGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQ 224
                       D+++C I + SP+  +   D F    +D  +            + + +
Sbjct: 231 FQGSSDGVEVRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRG----------LLVNE 280

Query: 225 DVFSALAGQGQIYVHLTDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWI- 283
           ++        QI++H+T       K  G+ +    +Y +   D     +   TP   +  
Sbjct: 281 EILG-----NQIHMHVT------AKEYGARVSNLHMYSAVCADVIRRWVYPLTPEANFTD 329

Query: 284 ---------RGNVYIHPTAKVAPSAVLGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHT 334
                    R N+Y  P   +   ++L  NV +G G  +G    +  S++  G  + ++ 
Sbjct: 330 STTQSCTHSRHNIYRGPEVSLGHGSILEENVLLGSGTVIGSNCFITNSVIGPGCHIGDNV 389

Query: 335 CVLHSIVGWGSTVGRWARVEGTPSDPNPNDPRARMDSESLFKDGKLLPAITILGCRVRIP 394
            +  + +  G  V   A++  +    N     A +      K   +L +  ++G  + +P
Sbjct: 390 VLDQTYLWQGVRVAAGAQIHQSLLCDN-----AEVKERVTLKPRSVLTSQVVVGPNITLP 444


>gi|9966779 eukaryotic translation initiation factor 2B, subunit 3
           gamma [Homo sapiens]
          Length = 452

 Score = 35.8 bits (81), Expect = 0.075
 Identities = 30/131 (22%), Positives = 60/131 (45%), Gaps = 19/131 (14%)

Query: 5   VILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQPDEP 64
           V+ +GG   G+R   L+  +PKPL PV   P+I + +    +V G +E++++        
Sbjct: 7   VMAVGG---GSRMTDLTSSIPKPLLPVGNKPLIWYPLNLLERV-GFEEVIVV-------T 55

Query: 65  LTQFLEAAQQEFNLPVR----YLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSD 120
                +A   EF + ++     + + A +GT   L +   ++         VL+ D+ +D
Sbjct: 56  TRDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKLKTD----VLVLSCDLITD 111

Query: 121 FPLSAMLEAHR 131
             L  +++  R
Sbjct: 112 VALHEVVDLFR 122



 Score = 30.4 bits (67), Expect = 3.1
 Identities = 28/144 (19%), Positives = 57/144 (39%), Gaps = 37/144 (25%)

Query: 233 QGQIYVHLT-DGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHP 291
           Q + YVH+  +G+ S++ + G  + A+R          P+ L+   P  P +  +  I  
Sbjct: 297 QVRCYVHIMKEGLCSRVSTLGLYMEANRQV--------PKLLSALCPEEPPVHSSAQIVS 348

Query: 292 TAKVAPSAVLGPNVSIGK----------------------------GVTVGEGVRLRESI 323
              V   +++GP   IG+                             VTV EG  ++ S+
Sbjct: 349 KHLVGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNSVTVEEGSNIQGSV 408

Query: 324 VLHGATLQEHTCVLHSIVGWGSTV 347
           + + A +++   +   ++G G  +
Sbjct: 409 ICNNAVIEKGADIKDCLIGSGQRI 432


>gi|223972704 hypothetical protein LOC284418 [Homo sapiens]
          Length = 922

 Score = 31.6 bits (70), Expect = 1.4
 Identities = 19/57 (33%), Positives = 28/57 (49%)

Query: 137 FLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINCGIYLFSPEALKP 193
           F ++ +TAN+TQS    C   + +     H VE PS  +S     G +L S  +L P
Sbjct: 281 FSIISSTANQTQSSPKACTSASDEATGQGHVVESPSHCVSADSPDGFFLGSCSSLDP 337


>gi|105990532 apolipoprotein B precursor [Homo sapiens]
          Length = 4563

 Score = 30.4 bits (67), Expect = 3.1
 Identities = 15/40 (37%), Positives = 24/40 (60%)

Query: 374  LFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRS 413
            +F     +P+ +ILG  VR+P+  LIL S+ LP   + R+
Sbjct: 3273 VFPKAVSMPSFSILGSDVRVPSYTLILPSLELPVLHVPRN 3312


>gi|170016069 zinc finger, CCHC domain containing 2 [Homo sapiens]
          Length = 1178

 Score = 29.3 bits (64), Expect = 7.0
 Identities = 39/162 (24%), Positives = 56/162 (34%), Gaps = 15/162 (9%)

Query: 148 QSLNYGCIVENPQTHEVLHYVEKPSTFISDIINCGIYLFSPEAL-----KPLRDVFQRNQ 202
           Q  +  C V  PQ       +  P+T    I N G +  SP A      K    V   NQ
Sbjct: 821 QGSSESCTVNIPQQPPGSLSIASPNTAFIPIHNPGSFPGSPVATTDPITKSASQVVGLNQ 880

Query: 203 QDGQLEDSPG----------LWPGAGTIRLEQDVFSALAGQGQIYVHLTDGIWSQIKSAG 252
              Q+E + G          + P AG    +      L G       L     S + +A 
Sbjct: 881 MVPQIEGNTGTVPQPTNVKVVLPAAGLSAAQPPASYPLPGSPLAAGVLPSQNSSVLSTAA 940

Query: 253 SALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAK 294
           ++   +   +S+ Q T P  +  HTPG          H TA+
Sbjct: 941 TSPQPASAGISQAQATVPPAVPTHTPGPAPSPSPALTHSTAQ 982


>gi|156151386 hypothetical protein LOC80157 [Homo sapiens]
          Length = 699

 Score = 28.9 bits (63), Expect = 9.1
 Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 4/53 (7%)

Query: 313 VGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTP---SDPNP 362
           V  G+  R + +L GA       + H + G  S V RWA V G P    DPNP
Sbjct: 185 VATGMASRPNWLLAGAAFGSLVFLTHWVFGEVSLVSRWA-VSGHPHPGPDPNP 236


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,026,924
Number of Sequences: 37866
Number of extensions: 899045
Number of successful extensions: 1755
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1719
Number of HSP's gapped (non-prelim): 18
length of query: 420
length of database: 18,247,518
effective HSP length: 105
effective length of query: 315
effective length of database: 14,271,588
effective search space: 4495550220
effective search space used: 4495550220
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.