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Search of human proteins with 31881770
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 1652 0.0
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 542 e-154
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 527 e-149
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 491 e-138
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 491 e-138
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 491 e-138
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 491 e-138
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 485 e-137
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 353 3e-97
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 350 4e-96
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 349 5e-96
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 339 5e-93
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 315 1e-85
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 315 1e-85
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 305 8e-83
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 295 1e-79
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 292 9e-79
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 288 1e-77
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 288 1e-77
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 288 1e-77
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 288 1e-77
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 288 1e-77
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 288 1e-77
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 284 2e-76
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 278 1e-74
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s... 261 2e-69
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 252 1e-66
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 249 5e-66
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 249 5e-66
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 249 5e-66
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 1652 bits (4279), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVS 60
MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVS
Sbjct: 1 MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVS 60
Query: 61 PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120
PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL
Sbjct: 61 PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120
Query: 121 DSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIE 180
DSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIE
Sbjct: 121 DSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIE 180
Query: 181 WQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTY 240
WQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTY
Sbjct: 181 WQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTY 240
Query: 241 FQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRK 300
FQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRK
Sbjct: 241 FQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRK 300
Query: 301 YNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLN 360
YNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLN
Sbjct: 301 YNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLN 360
Query: 361 CIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEE 420
CIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEE
Sbjct: 361 CIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEE 420
Query: 421 CQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPND 480
CQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPND
Sbjct: 421 CQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPND 480
Query: 481 VYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITG 540
VYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITG
Sbjct: 481 VYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITG 540
Query: 541 IRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGI 600
IRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGI
Sbjct: 541 IRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGI 600
Query: 601 PDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPF 660
PDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPF
Sbjct: 601 PDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPF 660
Query: 661 CEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQ 720
CEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQ
Sbjct: 661 CEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQ 720
Query: 721 EKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRP 780
EKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRP
Sbjct: 721 EKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRP 780
Query: 781 KAKSVKKQKK 790
KAKSVKKQKK
Sbjct: 781 KAKSVKKQKK 790
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 542 bits (1397), Expect = e-154
Identities = 292/730 (40%), Positives = 411/730 (56%), Gaps = 42/730 (5%)
Query: 12 RLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGK 71
R+ LLL+ + S+ P F S EV IP K+ RG +SY L+ G+
Sbjct: 11 RVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQ 70
Query: 72 KHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMG 131
KHV+H+ K+LL+ RHL VF++T+ LLED +IP DC Y G V+ + +S S C G
Sbjct: 71 KHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFG 130
Query: 132 GLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMAPYENK 189
G RGV I Y+IEP++ S +FEH+VY + QF CGL++ E+ Q +E
Sbjct: 131 GFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEA 190
Query: 190 ARLRDFPGS----YKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVR 245
P S + H +LEL+++ + + + +N+S+V D L+ I+D+ +Q +
Sbjct: 191 ENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQLG 250
Query: 246 MRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDAL 305
I L +E+W N + + +VL F +K+ L+ +L D AH++++ L
Sbjct: 251 TYIILIGIEIWNQGNVFPM--TSIEQVLNDFSQWKQISLS-QLQHDAAHMFIKNSLISIL 307
Query: 306 AWSFGKVCSLEYAGSVSTLLDTNI--LAPATWS------AHELGHAVGMSHDEQYCQCRG 357
++ AG +D + TWS AHELGH +GM HDE++C C G
Sbjct: 308 GLAY-------VAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFC-G 359
Query: 358 RLNCIMGSGRTG---FSNCSYISFFKHISSGATCLNNIPGLG--YVLKRCGNKIVEDNEE 412
CIM + R F+NCSY F K + +CL+N P LG ++LKRCGN +VE E+
Sbjct: 360 ERGCIMNTFRVPAEKFTNCSYADFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQ 419
Query: 413 CDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDG 472
CDCGS ++C++D CC NC L+PGA C+ GLCC DC+F PSG +CRQE NECDL E+C+G
Sbjct: 420 CDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNG 479
Query: 473 NSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQ 532
S CP D Y QDG PC C++K C + C+ IFG DA A CY +N G++
Sbjct: 480 TSHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNR 539
Query: 533 FGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYH 592
FG+C I G + KC ++ CGR+QC NV IP L +H T+ TH+ + CWG YH
Sbjct: 540 FGHCGING-TTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHI--NGVTCWGIDYH 596
Query: 593 LSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHC 652
L M I D+G + DGT CG G++C K CV+ SVL CLPE CN +G+CNN+ +CHC
Sbjct: 597 LR---MNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCNMKGICNNKHHCHC 653
Query: 653 MYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVI 712
YGW+PP+C+ GYGGSIDSGP RG I + S+ + L L + ++ RQ
Sbjct: 654 GYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSV--LTFLFTVGLLMYLRQCS 711
Query: 713 GNHLKPKQEK 722
G PK+ K
Sbjct: 712 G----PKETK 717
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 527 bits (1358), Expect = e-149
Identities = 269/679 (39%), Positives = 389/679 (57%), Gaps = 19/679 (2%)
Query: 8 LSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQ 67
L R+ LLL+ + S+ P F S EV IP K+ RG +SY L+
Sbjct: 57 LVHIRVTLLLLWFGMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLR 116
Query: 68 LKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATIS 127
G+++++H+ +LL HL VF++TE LL+D P+I DC Y G V+ +S +S
Sbjct: 117 FGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALS 176
Query: 128 TCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMA- 184
TC GG G+ I+ Y+I+P+ S +FEH+VY + + QF CGL++++I QM
Sbjct: 177 TCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMEL 236
Query: 185 --PYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQ 242
Y + F G + H +++EL+++ D RY F +N + V H+ + I+D+++
Sbjct: 237 QLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYH 296
Query: 243 DVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYN 302
+ + + L +++WT N + +L VL F I+K LN RL D AHL+++
Sbjct: 297 PLEVDVILTGIDIWTASNPLPTS-GDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDTQG 355
Query: 303 DALAWSFGK-VCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNC 361
L ++ K +C + V D ++ A HELGH +GM HD Q+C C + C
Sbjct: 356 MKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQW-C 414
Query: 362 IMGSGR---TGFSNCSYISFFKHISSGATCLNNIPGLGYV--LKRCGNKIVEDNEECDCG 416
IM + R T FSNCSY ++ S C+ P G + LK CGN +VE+ EECDCG
Sbjct: 415 IMHAYRKVTTKFSNCSYAQYWDSTISSGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCG 474
Query: 417 STEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSS 476
+ +C KD CC NC L PGA C+ G+CC DC+F PSG +CRQ+ ECDL E+C+G S
Sbjct: 475 TIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQ 534
Query: 477 CPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNC 536
CP+DVY QDG C C+ K C + +QC+ IFG DA A CY +N G++FG+C
Sbjct: 535 CPDDVYVQDGISCNVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHC 594
Query: 537 EITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMK 596
I G + KC + + +CGR+QC NV IP+L EH+T+ HL + CWGT YHL
Sbjct: 595 GIVG-TTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHL--NDTTCWGTDYHLG-- 649
Query: 597 PMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGW 656
M IPD+G + DGT CG ++C +K C + L C P+ CN RG+CNN+++CHC + W
Sbjct: 650 -MAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEW 708
Query: 657 APPFCEEVGYGGSIDSGPP 675
APP+C++ GYGGS DSGPP
Sbjct: 709 APPYCKDKGYGGSADSGPP 727
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 491 bits (1263), Expect = e-138
Identities = 267/793 (33%), Positives = 432/793 (54%), Gaps = 33/793 (4%)
Query: 13 LLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSP--VSYLLQLKG 70
LLLL + L G HP+ +V IP +++ G +G+ P +SY+L G
Sbjct: 4 LLLLHCLGVFLSCSGHIQDEHPQYHSPP-DVVIPVRIT--GTTRGMTPPGWLSYILPFGG 60
Query: 71 KKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCM 130
+KH++H+ K+LL +HL VF++T+ G +LED P++ +C Y G V+ +S ++STC
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 131 GGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMAPYE- 187
GG +G+ I+ Y+I+PL S +FEH+VY + E QF G +EI +M E
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 188 --NKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVR 245
+ + + G + H + +E++++ D Y N S+++ D ++ I+D+ +
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 246 MRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDAL 305
+++ L LE+WT+ N I V ++ + + + +K + R+ D +HL+
Sbjct: 241 VKVLLFGLEIWTNKNLIVVD--DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS 298
Query: 306 A-WSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMG 364
+F +C+ + ++ T ++ + + AH LGH +GM+HDE C+C + CIM
Sbjct: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRC-SQPRCIMH 357
Query: 365 SGR---TGFSNCSYISFFKHISSGATCLNNIPGLGYV--LKRCGNKIVEDNEECDCGSTE 419
G T FSNCSY F+++ CL + +KRCGN +VE+ EECDCG +
Sbjct: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
Query: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479
C KD CC SNC L G+ C+ GLCC DC+F PSG VCR+E NECDL E+C+G S CP+
Sbjct: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
Query: 480 DVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEIT 539
D Y +DG PCK G C+ K C R QC+ IFG A A CY +N +GD+ G+C
Sbjct: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHC--- 534
Query: 540 GIRN--FKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKP 597
GI+N + KC ++ CGR+QC NV IP++ +HTT+ + ++MCW T YHL MK
Sbjct: 535 GIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV--HWARFNDIMCWSTDYHLGMKG 592
Query: 598 MGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWA 657
PD+G + DGT CG +C ++CV+ ++L +C P CN RG+CNN+ +CHC Y W
Sbjct: 593 ---PDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWD 649
Query: 658 PPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLK 717
PP C GYGGS+DSGPP + + I++ ++ ++L ++ ++ +K
Sbjct: 650 PPNCLIKGYGGSVDSGPPP--KRKKKKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIK 705
Query: 718 PKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIES 777
+Q+ S + E+ + + + +S+ +S+ +S + +S+ +
Sbjct: 706 KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTP 765
Query: 778 KRPKAKSVKKQKK 790
+ + + + Q +
Sbjct: 766 SQSQPRVMPSQSQ 778
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 491 bits (1263), Expect = e-138
Identities = 267/793 (33%), Positives = 432/793 (54%), Gaps = 33/793 (4%)
Query: 13 LLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSP--VSYLLQLKG 70
LLLL + L G HP+ +V IP +++ G +G+ P +SY+L G
Sbjct: 4 LLLLHCLGVFLSCSGHIQDEHPQYHSPP-DVVIPVRIT--GTTRGMTPPGWLSYILPFGG 60
Query: 71 KKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCM 130
+KH++H+ K+LL +HL VF++T+ G +LED P++ +C Y G V+ +S ++STC
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 131 GGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMAPYE- 187
GG +G+ I+ Y+I+PL S +FEH+VY + E QF G +EI +M E
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 188 --NKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVR 245
+ + + G + H + +E++++ D Y N S+++ D ++ I+D+ +
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 246 MRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDAL 305
+++ L LE+WT+ N I V ++ + + + +K + R+ D +HL+
Sbjct: 241 VKVLLFGLEIWTNKNLIVVD--DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS 298
Query: 306 A-WSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMG 364
+F +C+ + ++ T ++ + + AH LGH +GM+HDE C+C + CIM
Sbjct: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRC-SQPRCIMH 357
Query: 365 SGR---TGFSNCSYISFFKHISSGATCLNNIPGLGYV--LKRCGNKIVEDNEECDCGSTE 419
G T FSNCSY F+++ CL + +KRCGN +VE+ EECDCG +
Sbjct: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
Query: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479
C KD CC SNC L G+ C+ GLCC DC+F PSG VCR+E NECDL E+C+G S CP+
Sbjct: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
Query: 480 DVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEIT 539
D Y +DG PCK G C+ K C R QC+ IFG A A CY +N +GD+ G+C
Sbjct: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHC--- 534
Query: 540 GIRN--FKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKP 597
GI+N + KC ++ CGR+QC NV IP++ +HTT+ + ++MCW T YHL MK
Sbjct: 535 GIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV--HWARFNDIMCWSTDYHLGMKG 592
Query: 598 MGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWA 657
PD+G + DGT CG +C ++CV+ ++L +C P CN RG+CNN+ +CHC Y W
Sbjct: 593 ---PDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWD 649
Query: 658 PPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLK 717
PP C GYGGS+DSGPP + + I++ ++ ++L ++ ++ +K
Sbjct: 650 PPNCLIKGYGGSVDSGPPP--KRKKKKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIK 705
Query: 718 PKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIES 777
+Q+ S + E+ + + + +S+ +S+ +S + +S+ +
Sbjct: 706 KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTP 765
Query: 778 KRPKAKSVKKQKK 790
+ + + + Q +
Sbjct: 766 SQSQPRVMPSQSQ 778
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 491 bits (1263), Expect = e-138
Identities = 267/793 (33%), Positives = 432/793 (54%), Gaps = 33/793 (4%)
Query: 13 LLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSP--VSYLLQLKG 70
LLLL + L G HP+ +V IP +++ G +G+ P +SY+L G
Sbjct: 4 LLLLHCLGVFLSCSGHIQDEHPQYHSPP-DVVIPVRIT--GTTRGMTPPGWLSYILPFGG 60
Query: 71 KKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCM 130
+KH++H+ K+LL +HL VF++T+ G +LED P++ +C Y G V+ +S ++STC
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 131 GGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMAPYE- 187
GG +G+ I+ Y+I+PL S +FEH+VY + E QF G +EI +M E
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 188 --NKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVR 245
+ + + G + H + +E++++ D Y N S+++ D ++ I+D+ +
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 246 MRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDAL 305
+++ L LE+WT+ N I V ++ + + + +K + R+ D +HL+
Sbjct: 241 VKVLLFGLEIWTNKNLIVVD--DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS 298
Query: 306 A-WSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMG 364
+F +C+ + ++ T ++ + + AH LGH +GM+HDE C+C + CIM
Sbjct: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRC-SQPRCIMH 357
Query: 365 SGR---TGFSNCSYISFFKHISSGATCLNNIPGLGYV--LKRCGNKIVEDNEECDCGSTE 419
G T FSNCSY F+++ CL + +KRCGN +VE+ EECDCG +
Sbjct: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
Query: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479
C KD CC SNC L G+ C+ GLCC DC+F PSG VCR+E NECDL E+C+G S CP+
Sbjct: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
Query: 480 DVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEIT 539
D Y +DG PCK G C+ K C R QC+ IFG A A CY +N +GD+ G+C
Sbjct: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHC--- 534
Query: 540 GIRN--FKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKP 597
GI+N + KC ++ CGR+QC NV IP++ +HTT+ + ++MCW T YHL MK
Sbjct: 535 GIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV--HWARFNDIMCWSTDYHLGMKG 592
Query: 598 MGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWA 657
PD+G + DGT CG +C ++CV+ ++L +C P CN RG+CNN+ +CHC Y W
Sbjct: 593 ---PDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWD 649
Query: 658 PPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLK 717
PP C GYGGS+DSGPP + + I++ ++ ++L ++ ++ +K
Sbjct: 650 PPNCLIKGYGGSVDSGPPP--KRKKKKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIK 705
Query: 718 PKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIES 777
+Q+ S + E+ + + + +S+ +S+ +S + +S+ +
Sbjct: 706 KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTP 765
Query: 778 KRPKAKSVKKQKK 790
+ + + + Q +
Sbjct: 766 SQSQPRVMPSQSQ 778
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 491 bits (1263), Expect = e-138
Identities = 267/793 (33%), Positives = 432/793 (54%), Gaps = 33/793 (4%)
Query: 13 LLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSP--VSYLLQLKG 70
LLLL + L G HP+ +V IP +++ G +G+ P +SY+L G
Sbjct: 4 LLLLHCLGVFLSCSGHIQDEHPQYHSPP-DVVIPVRIT--GTTRGMTPPGWLSYILPFGG 60
Query: 71 KKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCM 130
+KH++H+ K+LL +HL VF++T+ G +LED P++ +C Y G V+ +S ++STC
Sbjct: 61 QKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTCF 120
Query: 131 GGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKE--QFGNQVCGLSDDEIEWQMAPYE- 187
GG +G+ I+ Y+I+PL S +FEH+VY + E QF G +EI +M E
Sbjct: 121 GGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI 180
Query: 188 --NKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVR 245
+ + + G + H + +E++++ D Y N S+++ D ++ I+D+ +
Sbjct: 181 DNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240
Query: 246 MRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDAL 305
+++ L LE+WT+ N I V ++ + + + +K + R+ D +HL+
Sbjct: 241 VKVLLFGLEIWTNKNLIVVD--DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS 298
Query: 306 A-WSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMG 364
+F +C+ + ++ T ++ + + AH LGH +GM+HDE C+C + CIM
Sbjct: 299 GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRC-SQPRCIMH 357
Query: 365 SGR---TGFSNCSYISFFKHISSGATCLNNIPGLGYV--LKRCGNKIVEDNEECDCGSTE 419
G T FSNCSY F+++ CL + +KRCGN +VE+ EECDCG +
Sbjct: 358 EGNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLK 417
Query: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479
C KD CC SNC L G+ C+ GLCC DC+F PSG VCR+E NECDL E+C+G S CP+
Sbjct: 418 HCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPD 477
Query: 480 DVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEIT 539
D Y +DG PCK G C+ K C R QC+ IFG A A CY +N +GD+ G+C
Sbjct: 478 DFYVEDGIPCKERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHC--- 534
Query: 540 GIRN--FKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKP 597
GI+N + KC ++ CGR+QC NV IP++ +HTT+ + ++MCW T YHL MK
Sbjct: 535 GIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTV--HWARFNDIMCWSTDYHLGMKG 592
Query: 598 MGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWA 657
PD+G + DGT CG +C ++CV+ ++L +C P CN RG+CNN+ +CHC Y W
Sbjct: 593 ---PDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWD 649
Query: 658 PPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLK 717
PP C GYGGS+DSGPP + + I++ ++ ++L ++ ++ +K
Sbjct: 650 PPNCLIKGYGGSVDSGPPP--KRKKKKKFCYLCILLLIVLFILLCCLYRLCKK--SKPIK 705
Query: 718 PKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIES 777
+Q+ S + E+ + + + +S+ +S+ +S + +S+ +
Sbjct: 706 KQQDVQTPSAKEEEKIQRRPHELPPQSQPWVMPSQSQPPVTPSQSHPQVMPSQSQPPVTP 765
Query: 778 KRPKAKSVKKQKK 790
+ + + + Q +
Sbjct: 766 SQSQPRVMPSQSQ 778
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 485 bits (1248), Expect = e-137
Identities = 274/727 (37%), Positives = 407/727 (55%), Gaps = 34/727 (4%)
Query: 32 FHPEGEFDSYEVTIPEKLSF--RGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLR 89
F SYE+ P +L+ R + VSY++Q +GK+H++HL + LLP
Sbjct: 34 FQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFV 93
Query: 90 VFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPL 149
V+++ + G L+ DHP I C+Y G V+ +S +S C G LRG+ +++ Y IEPL
Sbjct: 94 VYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFG-LRGLLHLENASYGIEPL 152
Query: 150 KASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKAR------LRDFPGSYKHPK 203
+ S FEH++Y + CG+S+ +IE + A E + LR +
Sbjct: 153 QNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTR 212
Query: 204 YLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIR 263
Y+EL ++ D+ RY + N + V + ILL +D+ + + +RI L LE+WT+ N I
Sbjct: 213 YVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLIN 272
Query: 264 VGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSF-GKVCSLEYAGSVS 322
+ +VLG FV +++ L R D A L L++ + +F G VCS +AG ++
Sbjct: 273 I-VGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGIN 331
Query: 323 TLLDTNILAPATWSAHELGHAVGMSHDE-QYCQCRGRLNCIMGSGRTG---FSNCSYISF 378
+ A+ AHELGH +GM+HD+ + C C G +CIM SG +G FS+CS F
Sbjct: 332 VFGQITVETFASIVAHELGHNLGMNHDDGRDCSC-GAKSCIMNSGASGSRNFSSCSAEDF 390
Query: 379 FK-HISSGATCLNNIP--GLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQ-SNCKLQ 434
K ++ G CL NIP Y CGNK+V+ EECDCG+ +EC+ D CC+ S CKL+
Sbjct: 391 EKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLK 450
Query: 435 PGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEG 493
A C+ G CC DCRF P G +CR + +ECD+ EYC+G+S C DV+ Q+G PC+ +
Sbjct: 451 SFAECAYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKA 510
Query: 494 RCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSI 553
C+ C+ QCQ IFG A AP +C+ VN GD+FGNC +G +KKC + N++
Sbjct: 511 YCYNGMCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSG-NEYKKCATGNAL 569
Query: 554 CGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCG 613
CG+LQC NV+ IP II T + CWG + L +PD GM+N+GT CG
Sbjct: 570 CGKLQCENVQEIPVFGIVPAIIQT--PSRGTKCWGVDFQLG---SDVPDPGMVNEGTKCG 624
Query: 614 EGRVCFKKNCVNSSVLQFDC-LPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDS 672
G++C CV++SVL +DC + +KC+ GVCN+ KNCHC GWAPP CE GYGGS+DS
Sbjct: 625 AGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDS 684
Query: 673 GPP-GLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFR--QVIGNHLKPKQEKMPLSKAK 729
GP + A+ + V F ++ LI+ +F+F + Q+ ++ + K+ + S K
Sbjct: 685 GPTYNEMNTALRDGLLV---FFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGK 741
Query: 730 TEQEESK 736
+ S+
Sbjct: 742 NQANPSR 748
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 353 bits (906), Expect = 3e-97
Identities = 232/693 (33%), Positives = 344/693 (49%), Gaps = 55/693 (7%)
Query: 100 LEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAK-HYQIEPLKASPSFEHV 158
LEDH C Y G+V+E+ S T+STC G +RG+ + + Y IEPL S +H+
Sbjct: 109 LEDH------CFYHGTVRETELSSVTLSTCRG-IRGLITVSSNLSYVIEPLPDSKG-QHL 160
Query: 159 VYLLK--KEQFGNQVCGLSDDEI---EW--QMAPYENKARLRDFPGSYKHPKYLELILLF 211
+Y + K GN CG + +W Q K R KY+EL L+
Sbjct: 161 IYRSEHLKPPPGN--CGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVA 218
Query: 212 DQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAE 271
D ++ + H I + +D +++ + +RI L LEVWT N V +
Sbjct: 219 DYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYS- 277
Query: 272 VLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAW--SFGKVCSLEYAGSVSTLLDTNI 329
L F+ +++ +L A+ D A L ++ +CS+ +G V+ N
Sbjct: 278 TLWSFLSWRRKLL-AQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENA 336
Query: 330 LAPATWSAHELGHAVGMSHDEQYCQCRGRLN--CIMGSGRTG------FSNCSYISFFKH 381
+ A AHE+GH GM+HD C + CIM + TG F+ C+ ++
Sbjct: 337 IGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAA-TGHPFPKVFNGCNRRELDRY 395
Query: 382 ISSGA-TCLNNIPG--LGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGAN 438
+ SG CL+N+P + Y +RCGN +ED EECDCG EEC C SNC L+PGA
Sbjct: 396 LQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAE 455
Query: 439 CSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFR 497
C+ G CCH C+ G +CR++ +CDL E+C G S CP + Y+ DGTPC+ + C+
Sbjct: 456 CAHGSCCHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYN 515
Query: 498 KGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRL 557
C + QCQ ++GP A AP C++ VN+ GD FGNC +KC ++ CG++
Sbjct: 516 GMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKI 575
Query: 558 QCINVETIP----DLPEHTTIISTHLQAENLMCWGTGYHLSMKPMG-IPDLGMINDGTSC 612
QC + E P +P TTII + + C GT + + G + D G++ GT C
Sbjct: 576 QCQSSEARPLESNAVPIDTTII---MNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKC 632
Query: 613 GEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDS 672
G +CF+ C N+S + + +KCN GVCNN +NCHC+ GWAPPFC G+GGSIDS
Sbjct: 633 GYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDS 692
Query: 673 GPPGLLRGAIPSSIW--VVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKT 730
GP P S+ V +++ L+L +L +++ RQ + K Q K +K
Sbjct: 693 GP------MPPESVGPVVAGVLVAILVLAVLMLMYYCCRQ----NNKLGQLKPSALPSKL 742
Query: 731 EQEESKTKTVQEESKTKTGQEESEAKTGQEESK 763
Q+ S V + S T + +T Q + K
Sbjct: 743 RQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRK 775
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 350 bits (897), Expect = 4e-96
Identities = 228/713 (31%), Positives = 353/713 (49%), Gaps = 59/713 (8%)
Query: 25 SLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLL 84
S+G ++ P FDS PE L+ R LQ + K+ +++L L+
Sbjct: 46 SVGSGDLWIPVKSFDSKNH--PEVLNIR-------------LQRESKELIINLERNEGLI 90
Query: 85 PRHLRVFSFTEHG---ELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDA 141
+ + G L ++ I C Y G V+ DS ++STC GLRG+ +
Sbjct: 91 ASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFEN 149
Query: 142 KHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMA-----PYENKARLRDFP 196
+ Y +EP+K++ + + ++ KK + CG + P + AR R
Sbjct: 150 ESYVLEPMKSATN-RYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWAR-RHKR 207
Query: 197 GSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVW 256
+ K KY+EL+++ D ++ +L +V I + +D +++ + +RI L +EVW
Sbjct: 208 ETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVW 267
Query: 257 TDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKV---C 313
D +K V L F+ ++K L R S D A L + Y + C
Sbjct: 268 NDMDKCSVSQDPFTS-LHEFLDWRKMKLLPRKSHDNAQL-VSGVYFQGTTIGMAPIMSMC 325
Query: 314 SLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD--EQYCQCRGRLN---CIMGSGRT 368
+ + +G + N L A AHELGH GM+HD ++ C C+ + CIM + T
Sbjct: 326 TADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNAS-T 384
Query: 369 G------FSNCSYISFFKHISSG-ATCLNNIPGL--GYVLKRCGNKIVEDNEECDCGSTE 419
G FS+CS + G CL N+P + + ++CGN+ VE+ EECDCG E
Sbjct: 385 GYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPE 444
Query: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479
EC C + C L+P A C+ GLCC DC+ +P+G CR N CDL E+C G S CP
Sbjct: 445 ECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPA 504
Query: 480 DVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEI 538
+VY DG C+ +G C+ C++ QC +++GP A AP C++ VN GD +GNC
Sbjct: 505 NVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGK 564
Query: 539 TGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHL---QAENLMCWGTGYHLSM 595
+F KCE ++ CG++QC + P + + I T++ Q ++C GT +L
Sbjct: 565 VSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLG- 623
Query: 596 KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYG 655
+PD G++ GT C +G++C + C N SV +C+ RGVCNNRKNCHC
Sbjct: 624 --DDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAH 681
Query: 656 WAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFF 708
WAPPFC++ G+GGS DSGP +R A + + ++ IL +L+ FV +
Sbjct: 682 WAPPFCDKFGFGGSTDSGP---IRQADNQGLTIGILV---TILCLLAAGFVVY 728
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 349 bits (896), Expect = 5e-96
Identities = 221/679 (32%), Positives = 338/679 (49%), Gaps = 53/679 (7%)
Query: 25 SLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLL 84
S+G ++ P FDS PE L+ R LQ + K+ +++L L+
Sbjct: 46 SVGSGDLWIPVKSFDSKNH--PEVLNIR-------------LQRESKELIINLERNEGLI 90
Query: 85 PRHLRVFSFTEHG---ELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDA 141
+ + G L ++ I C Y G V+ DS ++STC GLRG+ +
Sbjct: 91 ASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFEN 149
Query: 142 KHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMA-----PYENKARLRDFP 196
+ Y +EP+K++ + + ++ KK + CG + P + AR R
Sbjct: 150 ESYVLEPMKSATN-RYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWAR-RHKR 207
Query: 197 GSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVW 256
+ K KY+EL+++ D ++ +L +V I + +D +++ + +RI L +EVW
Sbjct: 208 ETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVW 267
Query: 257 TDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKV---C 313
D +K V L F+ ++K L R S D A L + Y + C
Sbjct: 268 NDMDKCSVSQDPFTS-LHEFLDWRKMKLLPRKSHDNAQL-VSGVYFQGTTIGMAPIMSMC 325
Query: 314 SLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD--EQYCQCRGRLN---CIMGSGRT 368
+ + +G + N L A AHELGH GM+HD ++ C C+ + CIM + T
Sbjct: 326 TADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNAS-T 384
Query: 369 G------FSNCSYISFFKHISSG-ATCLNNIPGL--GYVLKRCGNKIVEDNEECDCGSTE 419
G FS+CS + G CL N+P + + ++CGN+ VE+ EECDCG E
Sbjct: 385 GYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPE 444
Query: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479
EC C + C L+P A C+ GLCC DC+ +P+G CR N CDL E+C G S CP
Sbjct: 445 ECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPA 504
Query: 480 DVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEI 538
+VY DG C+ +G C+ C++ QC +++GP A AP C++ VN GD +GNC
Sbjct: 505 NVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGK 564
Query: 539 TGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHL---QAENLMCWGTGYHLSM 595
+F KCE ++ CG++QC + P + + I T++ Q ++C GT +L
Sbjct: 565 VSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLG- 623
Query: 596 KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYG 655
+PD G++ GT C +G++C + C N SV +C+ RGVCNNRKNCHC
Sbjct: 624 --DDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAH 681
Query: 656 WAPPFCEEVGYGGSIDSGP 674
WAPPFC++ G+GGS DSGP
Sbjct: 682 WAPPFCDKFGFGGSTDSGP 700
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 339 bits (870), Expect = 5e-93
Identities = 238/696 (34%), Positives = 353/696 (50%), Gaps = 72/696 (10%)
Query: 35 EGEFDSY--EVTIPEKLSFRGEV-QGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVF 91
+ FDS ++T+PEK+ R + +G+ S SY + ++GK + ++L K L P + RV+
Sbjct: 17 DSNFDSLPVQITVPEKI--RSIIKEGIESQASYKIVIEGKPYTVNLMQKNFL-PHNFRVY 73
Query: 92 SFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKA 151
S++ G + C+Y G ++ S +STC G LRGV + Y IEPL++
Sbjct: 74 SYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTG-LRGVLQFENVSYGIEPLES 132
Query: 152 SPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKHPKYLELILLF 211
S FEHV+Y +K ++ + D E ++ +DF KY+E+ ++
Sbjct: 133 SVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFA------KYIEMHVIV 186
Query: 212 DQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAE 271
++ Y + ++ + V L G+ + F + I L +LE+W D NKI E E
Sbjct: 187 EKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATT-GEANE 245
Query: 272 VLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSF-GKVCSLEYAGSVSTLLDTNIL 330
+L F+ +K S L R D A L + R+ ++ + +F GK+C YAG V +L
Sbjct: 246 LLHTFLRWKTSYLVLR-PHDVAFLLVYREKSNYVGATFQGKMCDANYAGGV-------VL 297
Query: 331 APATWS--------AHELGHAVGMSHDE-QYCQCRGRLNCIMG------SGRTGFSNCSY 375
P T S A L ++G+++D+ CQC G + CIM SG FSNCS+
Sbjct: 298 HPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAV-CIMNPEAIHFSGVKIFSNCSF 356
Query: 376 ISFFKHISSGAT-CLNNIPGLGYVLKR---CGNKIVEDNEECDCGSTEECQK--DRCCQ- 428
F IS + CL+N P L K+ CGN +E EECDCG+ ++C + CC
Sbjct: 357 EDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDI 416
Query: 429 SNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTP 488
+ C+ + G+NC+ G CC +C F +CR ECDL EYC+G+S+SCP + Y Q G P
Sbjct: 417 ATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHP 476
Query: 489 CKY-EGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKC 547
C + C C S QC FG + PSECY +N D GNC I+ + +C
Sbjct: 477 CGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISD-SGYTQC 535
Query: 548 ESANSICGRLQCINV-ETIPDLPEHTTI---ISTHLQAENLMCWGTGY---HLSMKPMGI 600
E+ N CG+L C V + + +P T I IS HL C + H + M
Sbjct: 536 EADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL------CIAVEFASDHADSQKM-- 587
Query: 601 PDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPF 660
I DGTSCG +VC + CV+SS L +DC +KCN RGVCNN+K+CHC + PP
Sbjct: 588 ----WIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPD 643
Query: 661 C---EEVGYGGSIDSG--PPGLLRGAIPSSIWVVSI 691
C ++ GGSIDSG PP + +P ++ +I
Sbjct: 644 CSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENI 679
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 315 bits (806), Expect = 1e-85
Identities = 208/633 (32%), Positives = 313/633 (49%), Gaps = 33/633 (5%)
Query: 66 LQLKGKKHVLHLWPK-RLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKA 124
L+ +G++ +L L RLL P ++ + G+ + P C+Y G V+ DS
Sbjct: 70 LEAEGQELLLELEKNHRLLAPGYIETH-YGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWV 128
Query: 125 TISTCMGGLRGVFNI--DAKHY-QIEPLKASPSFE-HVVYLLKKEQFGNQVCGLSDDEIE 180
+ TC G+ G+ + +A +Y + P + S F H ++ +++ CG D +
Sbjct: 129 VLCTC-SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNK 187
Query: 181 WQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTY 240
M + R + + KYLEL ++ D + + + NL+ + + +D
Sbjct: 188 AGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQL 247
Query: 241 FQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRK 300
+ + +++ L LEVWT+ ++ RV A L F+ +++ L A+ D A L R
Sbjct: 248 LRTLDIQVALTGLEVWTERDRSRVTQDANA-TLWAFLQWRRG-LWAQRPHDSAQLLTGRA 305
Query: 301 YNDA---LAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRG 357
+ A LA G +C E +G VST + A AHE+GH++G+SHD C
Sbjct: 306 FQGATVGLAPVEG-MCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEA 364
Query: 358 RLN---CIMGSGRTG------FSNCS---YISFFKHISSGATCLNNIP--GLGYVLKRCG 403
C+M + TG FS CS +FF+ G CL+N P GL CG
Sbjct: 365 AAESGGCVMAAA-TGHPFPRVFSACSRRQLRAFFR--KGGGACLSNAPDPGLPVPPALCG 421
Query: 404 NKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNE 463
N VE EECDCG +EC+ C NC L+PGA C+ G CC C +P+G +CRQ +
Sbjct: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
Query: 464 CDLAEYCDGNSSSCPNDVYKQDGTPC-KYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSEC 522
CDL E+C G SS CP DVY DG+PC + G C+ C + QCQ ++GP + AP C
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
Query: 523 YDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIST-HLQA 581
+ VN GD GNC +F C +++CG+LQC + P + ST HL
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDG 601
Query: 582 ENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTR 641
+ + C G L + + LG++ GT CG VC + C ++ + C++
Sbjct: 602 QEVTCRG-ALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSH 660
Query: 642 GVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGP 674
GVCN+ NCHC GWAPPFC++ G+GGS+DSGP
Sbjct: 661 GVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGP 693
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 315 bits (806), Expect = 1e-85
Identities = 228/772 (29%), Positives = 379/772 (49%), Gaps = 51/772 (6%)
Query: 42 EVTIPEKLSFRGEVQGVVS--PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGEL 99
++ IPEK+ + +SY++ + K + +HL +R L + ++ + + G +
Sbjct: 27 QIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLYTVHL-KQRYFLADNFMIYLYNQ-GSM 84
Query: 100 LEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVV 159
I C Y G+++ DS T+STC GLRG+ + Y IEPL+++ F+HV+
Sbjct: 85 NTYSSDIQTQCYYQGNIEGYPDSMVTLSTC-SGLRGILQFENVSYGIEPLESAVEFQHVL 143
Query: 160 YLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRD-----FPGSYKHPKYLELILLFDQS 214
Y LK E N + D ++ Q P ++ + + P + P YLE+ ++ D++
Sbjct: 144 YKLKNED--NDIAIFIDRSLKEQ--PMDDNIFISEKSEPAVPDLF--PLYLEMHIVVDKT 197
Query: 215 RYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLG 274
Y + ++ V + I + G+ ++ F ++ I L +LE+W+D NKI E E+L
Sbjct: 198 LYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKIST-VGEADELLQ 256
Query: 275 RFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSF-GKVCSLEYAGSVSTL-LDTNILAP 332
+F+ +K+S LN R D A+L + Y L F G +C Y+ V+ + + A
Sbjct: 257 KFLEWKQSYLNLR-PHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAF 315
Query: 333 ATWSAHELGHAVGMSHDE-QYCQCRGRLNCIMG------SGRTGFSNCSYISFFKHISS- 384
A L ++G+S+D+ + CQC CIM +G FS+CS SF IS+
Sbjct: 316 AVIVTQMLALSLGISYDDPKKCQC-SESTCIMNPEVVQSNGVKTFSSCSLRSFQNFISNV 374
Query: 385 GATCLNNIPGLGYVLKR--CGNKIVEDNEECDCGSTEECQKDRCCQ-SNCKLQPGANCSI 441
G CL N P + + CGN +E NE CDCG+ +C CC C L+ GA C
Sbjct: 375 GVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVLKDGAKCYK 434
Query: 442 GLCCHDCRFRPSGYVCRQEGN-ECDLAEYCDGNSSSCPNDVYKQDGTPCKYEGR-CFRKG 499
GLCC DC+ SG CR + + ECD+AE C+G+S C D+ +G CK C+
Sbjct: 435 GLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFICYDGD 494
Query: 500 CRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQC 559
C +C+S+FG + AP CY+ + D+FGNC + C N ICGRL C
Sbjct: 495 CHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVC 554
Query: 560 INVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCF 619
P E+ +I ++ + +C Y L P +PD + +G+ C GRVC
Sbjct: 555 TYPTRKPFHQENGDVIYAFVR--DSVCITVDYKL---PRTVPDPLAVKNGSQCDIGRVCV 609
Query: 620 KKNCVNSSVLQFDC--LPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSI----DSG 673
+ CV S +++ ++C+ GVC++R CHC G+ PP C+ G SI D G
Sbjct: 610 NRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMG 669
Query: 674 PPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKTEQE 733
+ W++ ++ IL++ + + + +Q+ K+E+ P S++K+
Sbjct: 670 SIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQL--KKWFAKEEEFPSSESKS--- 724
Query: 734 ESKTKTVQEESKTKTGQEESEAKTGQE-ESKAKTGQEESKANIESKRPKAKS 784
E T+T +S ++ + ++T E S+A T + +S+ + E+ ++KS
Sbjct: 725 EGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKS 776
>gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
Length = 739
Score = 305 bits (782), Expect = 8e-83
Identities = 210/674 (31%), Positives = 332/674 (49%), Gaps = 35/674 (5%)
Query: 22 LLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKR 81
LL LG + H E VT+P K+ + + + Y++ + G+ + LHL K+
Sbjct: 7 LLTELGR-LQAHEGSEGIFLHVTVPRKIK-SNDSEVSERKMIYIITIDGQPYTLHLG-KQ 63
Query: 82 LLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDA 141
LP++ V+++ E G L PY C+Y G E +S T+S C GLRG +
Sbjct: 64 SFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSIC-SGLRGFLQFEN 122
Query: 142 KHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKH 201
Y IEP+++S FEH++Y +K + ++ I + PY+ + S
Sbjct: 123 ISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSKLL 182
Query: 202 PKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNK 261
P+YLE+ ++ +++ Y ++ + + V + + G+++T F ++ + L +LE+W++ N+
Sbjct: 183 PQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNENQ 242
Query: 262 IRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSF-GKVCSLEYAGS 320
I + ++L RF+ +K+ L R D A+L + RK+ + +F G VC+ Y
Sbjct: 243 ISTS-GDADDILQRFLAWKRDYLILR-PHDIAYLLVYRKHPKYVGATFPGTVCNKSYDAG 300
Query: 321 VSTLLDT-NILAPATWSAHELGHAVGMSHDE-QYCQCRGRLNCIMG------SGRTGFSN 372
++ D + + A LG VG+++D+ C C R CIM SGR FSN
Sbjct: 301 IAMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCL-RATCIMNHEAVSASGRKIFSN 359
Query: 373 CSYISFFKHISSGAT-CLNNIPGLGYVLKR---CGNKIVEDNEECDCGSTEECQKDRCCQ 428
CS + +S T CL + L + + CGN I+E NEECDCG+ ECQ +CC
Sbjct: 360 CSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPVCGNGILESNEECDCGNKNECQFKKCCD 419
Query: 429 SN-CKLQPGANCSIGLCC-HDCRFRPSGYVCRQE-GNECDLAEYCDGNSSSCPNDVYKQD 485
N CKL+ C G CC C +G CR+ ECD EYC+G SS+C D Y +
Sbjct: 420 YNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRKSIDPECDFTEYCNGTSSNCVPDTYALN 479
Query: 486 GTPCKY-EGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNF 544
G CK C+ C++ QC IFG A AP C+ VN + ++ NC G +N
Sbjct: 480 GRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQGAPFACFKEVNSLHERSENC---GFKNS 536
Query: 545 K--KCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPD 602
+ CE + +CG+L C+ + + + + +++Q + TG SM+ G D
Sbjct: 537 QPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSYIQDHVCVSIATG--SSMRSDG-TD 593
Query: 603 LGMINDGTSCGEGRVCFKKNCVNSSVLQFDC-LPEKCNTRGVCNNRKNCHCMYGWAPPFC 661
+ DGT CG C K C ++ ++C KC +G+CNN NC C G PP C
Sbjct: 594 NAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKGKGICNNFGNCQCFPGHRPPDC 653
Query: 662 E-EVGY-GGSIDSG 673
+ + G GGSID G
Sbjct: 654 KFQFGSPGGSIDDG 667
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 295 bits (754), Expect = 1e-79
Identities = 202/619 (32%), Positives = 302/619 (48%), Gaps = 36/619 (5%)
Query: 64 YLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSK 123
Y ++L K VLHL R L + ++ GE HP I C Y GS+ DS
Sbjct: 61 YEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSA 120
Query: 124 ATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVV--YLLKKEQFGNQVCGLSDDEIEW 181
A+ISTC GLRG F I+ + Y IEP+K S EH+V Y L+ N C ++
Sbjct: 121 ASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSC--TELNFTR 177
Query: 182 QMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYF 241
+ P +N++ KY+EL ++ D + YR + +++ + + ++ +
Sbjct: 178 KTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIY 237
Query: 242 QDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYL---Q 298
+ + + + L +E+WT +KI + Y + L RF +++ +L R D+ H+ L +
Sbjct: 238 KTLNIHVTLVGIEIWTHEDKIEL-YSNIETTLLRFSFWQEKILKTR--KDFDHVVLLSGK 294
Query: 299 RKYNDALAWSF-GKVCSLEYAGSV--STLLDTNILAPATWSAHELGHAVGMSHDEQYCQC 355
Y+ S+ G +C Y+ S+ L DTNI+A AH+LGH +GM HDE C C
Sbjct: 295 WLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRM--AHQLGHNLGMQHDEFPCTC 352
Query: 356 RGRLNCIMGSGRT----GFSNCSYISFFKHISS-GATCLNNIPGLG--YVLKRCGNKIVE 408
C+M S + FS CS + +++ TC+ NIP + + CGNK ++
Sbjct: 353 PSG-KCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLD 411
Query: 409 DNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAE 468
+ EECDCG +EC C C L+PG C+ G CC C+ + +G +CR +ECD E
Sbjct: 412 EGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPE 471
Query: 469 YCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVN 527
C G+S +CP D ++ +G PCK EG CF C +R QC +F +A+E+ CY +N
Sbjct: 472 MCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICY-KMN 530
Query: 528 LIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCW 587
G++FG C+ R F CE + CG++ C E L E T Q +
Sbjct: 531 TKGNKFGYCKNKENR-FLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKC 589
Query: 588 GT--GYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDC-LPEKCNTRGVC 644
T YH S D+G++ GT CGEG VC C+N + P +CN V
Sbjct: 590 KTIFLYHDS------TDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVD 643
Query: 645 NNRKNCHCMYGWAPPFCEE 663
+ CHC G AP CEE
Sbjct: 644 GHGLQCHCEEGQAPVACEE 662
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 292 bits (747), Expect = 9e-79
Identities = 204/633 (32%), Positives = 303/633 (47%), Gaps = 59/633 (9%)
Query: 66 LQLKGKKHVLHLWPK-RLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKA 124
L+ +G++ +L L RLL P ++ + G+ + P C+Y G V+ DS
Sbjct: 70 LEAEGQELLLELEKNHRLLAPGYIETH-YGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWV 128
Query: 125 TISTCMGGLRGVFNI--DAKHY-QIEPLKASPSFE-HVVYLLKKEQFGNQVCGLSDDEIE 180
+ TC G+ G+ + +A +Y + P + S F H ++ +++ CG D +
Sbjct: 129 VLCTC-SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNK 187
Query: 181 WQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTY 240
M + R + + KYLEL ++ D + + + NL+ + + +D
Sbjct: 188 AGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQL 247
Query: 241 FQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRK 300
+ + +++ L LEVWT+ ++ RV A L F+ +++ L A+ D A L R
Sbjct: 248 LRTLDIQVALTGLEVWTERDRSRVTQDANA-TLWAFLQWRRG-LWAQRPHDSAQLLTGRA 305
Query: 301 YNDA---LAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRG 357
+ A LA G +C E +G VST + A AHE+GH++G+SHD C
Sbjct: 306 FQGATVGLAPVEG-MCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEA 364
Query: 358 RLN---CIMGSGRTG------FSNCS---YISFFKHISSGATCLNNIP--GLGYVLKRCG 403
C+M + TG FS CS +FF+ G CL+N P GL CG
Sbjct: 365 AAESGGCVMAAA-TGHPFPRVFSACSRRQLRAFFR--KGGGACLSNAPDPGLPVPPALCG 421
Query: 404 NKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNE 463
N VE EECDCG +EC+ C NC L+PGA C+ G CC C +P+G +CRQ +
Sbjct: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
Query: 464 CDLAEYCDGNSSSCPNDVYKQDGTPC-KYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSEC 522
CDL E+C G SS CP DVY DG+PC + G C+ C + QCQ ++GP + AP C
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
Query: 523 YDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIST-HLQA 581
+ VN GD GNC +F C +++CG+LQC + P + ST HL
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDG 601
Query: 582 ENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTR 641
+ + C G L + + LG++ GT CG R
Sbjct: 602 QEVTCRG-ALALPSAQLDLLGLGLVEPGTQCG--------------------------PR 634
Query: 642 GVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGP 674
VCN+ NCHC GWAPPFC++ G+GGS+DSGP
Sbjct: 635 MVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGP 667
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 288 bits (737), Expect = 1e-77
Identities = 197/626 (31%), Positives = 297/626 (47%), Gaps = 34/626 (5%)
Query: 61 PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120
P+ L+L G H+L L R L+P + + G + + ++C Y G V+
Sbjct: 68 PLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYA 127
Query: 121 DSKATISTCMGGLRGVFNIDAKH-YQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI 179
S +I TC GLRG+ + + Y +E ++ ++ C LS E
Sbjct: 128 GSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 180 EWQMAPYEN---KARLRDFPGSYKHPKYLELILLFDQS---RYRFVNNNLSQVIHDAILL 233
P E+ + +R K +EL+++ D S +YR + L++ + A+LL
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 234 TGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWA 293
DT+F+ + +R+ L LE WT + + + P A L F+ ++++ L RL D A
Sbjct: 247 ----DTFFRPLNVRVALVGLEAWTQRDLVEIS-PNPAVTLENFLHWRRAHLLPRLPHDSA 301
Query: 294 HLYLQRKYNDALAWSF--GKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD-- 349
L ++ +CS +++G V+ T+IL A+ AHELGH++G+ HD
Sbjct: 302 QLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLP 361
Query: 350 EQYCQCRGRL---NCIMGSGRT-----GFSNCSYISFFKHISSG-ATCL-NNIPGLGYVL 399
C C G CIM + FSNCS + K + G +CL +P L +
Sbjct: 362 GNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMA 421
Query: 400 KRCGNKIVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANC-SIGLCCHDCRFRPSGYVC 457
CGN VE E+CDCG ++C D CC S C+L+PGA C S G CC +C+ RPSG+ C
Sbjct: 422 AFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 458 RQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAM 516
R +CDL E+C G+SS CP DV DG PC + C C S QCQS++GP A
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 517 EAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIS 576
A C N G+ FG+C ++ C ++ICG+LQC T P L ++
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 577 THLQAENLMCWGTGYHLSM-KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLP 635
+ + HL + + P L + GT+CG G VC C +L
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTL--PGTACGPGLVCIDHRCQRVDLLGAQECR 658
Query: 636 EKCNTRGVCNNRKNCHCMYGWAPPFC 661
KC+ GVC++ ++C+C GWAPP C
Sbjct: 659 SKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 288 bits (737), Expect = 1e-77
Identities = 197/626 (31%), Positives = 297/626 (47%), Gaps = 34/626 (5%)
Query: 61 PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120
P+ L+L G H+L L R L+P + + G + + ++C Y G V+
Sbjct: 68 PLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYA 127
Query: 121 DSKATISTCMGGLRGVFNIDAKH-YQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI 179
S +I TC GLRG+ + + Y +E ++ ++ C LS E
Sbjct: 128 GSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 180 EWQMAPYEN---KARLRDFPGSYKHPKYLELILLFDQS---RYRFVNNNLSQVIHDAILL 233
P E+ + +R K +EL+++ D S +YR + L++ + A+LL
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 234 TGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWA 293
DT+F+ + +R+ L LE WT + + + P A L F+ ++++ L RL D A
Sbjct: 247 ----DTFFRPLNVRVALVGLEAWTQRDLVEIS-PNPAVTLENFLHWRRAHLLPRLPHDSA 301
Query: 294 HLYLQRKYNDALAWSF--GKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD-- 349
L ++ +CS +++G V+ T+IL A+ AHELGH++G+ HD
Sbjct: 302 QLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLP 361
Query: 350 EQYCQCRGRL---NCIMGSGRT-----GFSNCSYISFFKHISSG-ATCL-NNIPGLGYVL 399
C C G CIM + FSNCS + K + G +CL +P L +
Sbjct: 362 GNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMA 421
Query: 400 KRCGNKIVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANC-SIGLCCHDCRFRPSGYVC 457
CGN VE E+CDCG ++C D CC S C+L+PGA C S G CC +C+ RPSG+ C
Sbjct: 422 AFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 458 RQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAM 516
R +CDL E+C G+SS CP DV DG PC + C C S QCQS++GP A
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 517 EAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIS 576
A C N G+ FG+C ++ C ++ICG+LQC T P L ++
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 577 THLQAENLMCWGTGYHLSM-KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLP 635
+ + HL + + P L + GT+CG G VC C +L
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTL--PGTACGPGLVCIDHRCQRVDLLGAQECR 658
Query: 636 EKCNTRGVCNNRKNCHCMYGWAPPFC 661
KC+ GVC++ ++C+C GWAPP C
Sbjct: 659 SKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 288 bits (737), Expect = 1e-77
Identities = 197/626 (31%), Positives = 297/626 (47%), Gaps = 34/626 (5%)
Query: 61 PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120
P+ L+L G H+L L R L+P + + G + + ++C Y G V+
Sbjct: 68 PLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYA 127
Query: 121 DSKATISTCMGGLRGVFNIDAKH-YQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI 179
S +I TC GLRG+ + + Y +E ++ ++ C LS E
Sbjct: 128 GSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 180 EWQMAPYEN---KARLRDFPGSYKHPKYLELILLFDQS---RYRFVNNNLSQVIHDAILL 233
P E+ + +R K +EL+++ D S +YR + L++ + A+LL
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 234 TGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWA 293
DT+F+ + +R+ L LE WT + + + P A L F+ ++++ L RL D A
Sbjct: 247 ----DTFFRPLNVRVALVGLEAWTQRDLVEIS-PNPAVTLENFLHWRRAHLLPRLPHDSA 301
Query: 294 HLYLQRKYNDALAWSF--GKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD-- 349
L ++ +CS +++G V+ T+IL A+ AHELGH++G+ HD
Sbjct: 302 QLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLP 361
Query: 350 EQYCQCRGRL---NCIMGSGRT-----GFSNCSYISFFKHISSG-ATCL-NNIPGLGYVL 399
C C G CIM + FSNCS + K + G +CL +P L +
Sbjct: 362 GNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMA 421
Query: 400 KRCGNKIVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANC-SIGLCCHDCRFRPSGYVC 457
CGN VE E+CDCG ++C D CC S C+L+PGA C S G CC +C+ RPSG+ C
Sbjct: 422 AFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 458 RQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAM 516
R +CDL E+C G+SS CP DV DG PC + C C S QCQS++GP A
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 517 EAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIS 576
A C N G+ FG+C ++ C ++ICG+LQC T P L ++
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 577 THLQAENLMCWGTGYHLSM-KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLP 635
+ + HL + + P L + GT+CG G VC C +L
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTL--PGTACGPGLVCIDHRCQRVDLLGAQECR 658
Query: 636 EKCNTRGVCNNRKNCHCMYGWAPPFC 661
KC+ GVC++ ++C+C GWAPP C
Sbjct: 659 SKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 288 bits (737), Expect = 1e-77
Identities = 197/626 (31%), Positives = 297/626 (47%), Gaps = 34/626 (5%)
Query: 61 PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120
P+ L+L G H+L L R L+P + + G + + ++C Y G V+
Sbjct: 68 PLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYA 127
Query: 121 DSKATISTCMGGLRGVFNIDAKH-YQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI 179
S +I TC GLRG+ + + Y +E ++ ++ C LS E
Sbjct: 128 GSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 180 EWQMAPYEN---KARLRDFPGSYKHPKYLELILLFDQS---RYRFVNNNLSQVIHDAILL 233
P E+ + +R K +EL+++ D S +YR + L++ + A+LL
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 234 TGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWA 293
DT+F+ + +R+ L LE WT + + + P A L F+ ++++ L RL D A
Sbjct: 247 ----DTFFRPLNVRVALVGLEAWTQRDLVEIS-PNPAVTLENFLHWRRAHLLPRLPHDSA 301
Query: 294 HLYLQRKYNDALAWSF--GKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD-- 349
L ++ +CS +++G V+ T+IL A+ AHELGH++G+ HD
Sbjct: 302 QLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLP 361
Query: 350 EQYCQCRGRL---NCIMGSGRT-----GFSNCSYISFFKHISSG-ATCL-NNIPGLGYVL 399
C C G CIM + FSNCS + K + G +CL +P L +
Sbjct: 362 GNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMA 421
Query: 400 KRCGNKIVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANC-SIGLCCHDCRFRPSGYVC 457
CGN VE E+CDCG ++C D CC S C+L+PGA C S G CC +C+ RPSG+ C
Sbjct: 422 AFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 458 RQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAM 516
R +CDL E+C G+SS CP DV DG PC + C C S QCQS++GP A
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 517 EAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIS 576
A C N G+ FG+C ++ C ++ICG+LQC T P L ++
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 577 THLQAENLMCWGTGYHLSM-KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLP 635
+ + HL + + P L + GT+CG G VC C +L
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTL--PGTACGPGLVCIDHRCQRVDLLGAQECR 658
Query: 636 EKCNTRGVCNNRKNCHCMYGWAPPFC 661
KC+ GVC++ ++C+C GWAPP C
Sbjct: 659 SKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 288 bits (737), Expect = 1e-77
Identities = 197/626 (31%), Positives = 297/626 (47%), Gaps = 34/626 (5%)
Query: 61 PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120
P+ L+L G H+L L R L+P + + G + + ++C Y G V+
Sbjct: 68 PLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYA 127
Query: 121 DSKATISTCMGGLRGVFNIDAKH-YQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI 179
S +I TC GLRG+ + + Y +E ++ ++ C LS E
Sbjct: 128 GSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 180 EWQMAPYEN---KARLRDFPGSYKHPKYLELILLFDQS---RYRFVNNNLSQVIHDAILL 233
P E+ + +R K +EL+++ D S +YR + L++ + A+LL
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 234 TGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWA 293
DT+F+ + +R+ L LE WT + + + P A L F+ ++++ L RL D A
Sbjct: 247 ----DTFFRPLNVRVALVGLEAWTQRDLVEIS-PNPAVTLENFLHWRRAHLLPRLPHDSA 301
Query: 294 HLYLQRKYNDALAWSF--GKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD-- 349
L ++ +CS +++G V+ T+IL A+ AHELGH++G+ HD
Sbjct: 302 QLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLP 361
Query: 350 EQYCQCRGRL---NCIMGSGRT-----GFSNCSYISFFKHISSG-ATCL-NNIPGLGYVL 399
C C G CIM + FSNCS + K + G +CL +P L +
Sbjct: 362 GNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMA 421
Query: 400 KRCGNKIVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANC-SIGLCCHDCRFRPSGYVC 457
CGN VE E+CDCG ++C D CC S C+L+PGA C S G CC +C+ RPSG+ C
Sbjct: 422 AFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 458 RQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAM 516
R +CDL E+C G+SS CP DV DG PC + C C S QCQS++GP A
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 517 EAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIS 576
A C N G+ FG+C ++ C ++ICG+LQC T P L ++
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 577 THLQAENLMCWGTGYHLSM-KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLP 635
+ + HL + + P L + GT+CG G VC C +L
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTL--PGTACGPGLVCIDHRCQRVDLLGAQECR 658
Query: 636 EKCNTRGVCNNRKNCHCMYGWAPPFC 661
KC+ GVC++ ++C+C GWAPP C
Sbjct: 659 SKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 288 bits (737), Expect = 1e-77
Identities = 197/626 (31%), Positives = 297/626 (47%), Gaps = 34/626 (5%)
Query: 61 PVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESL 120
P+ L+L G H+L L R L+P + + G + + ++C Y G V+
Sbjct: 68 PLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYA 127
Query: 121 DSKATISTCMGGLRGVFNIDAKH-YQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI 179
S +I TC GLRG+ + + Y +E ++ ++ C LS E
Sbjct: 128 GSWVSICTC-SGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 180 EWQMAPYEN---KARLRDFPGSYKHPKYLELILLFDQS---RYRFVNNNLSQVIHDAILL 233
P E+ + +R K +EL+++ D S +YR + L++ + A+LL
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNRTLEVALLL 246
Query: 234 TGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWA 293
DT+F+ + +R+ L LE WT + + + P A L F+ ++++ L RL D A
Sbjct: 247 ----DTFFRPLNVRVALVGLEAWTQRDLVEIS-PNPAVTLENFLHWRRAHLLPRLPHDSA 301
Query: 294 HLYLQRKYNDALAWSF--GKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD-- 349
L ++ +CS +++G V+ T+IL A+ AHELGH++G+ HD
Sbjct: 302 QLVTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLP 361
Query: 350 EQYCQCRGRL---NCIMGSGRT-----GFSNCSYISFFKHISSG-ATCL-NNIPGLGYVL 399
C C G CIM + FSNCS + K + G +CL +P L +
Sbjct: 362 GNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMA 421
Query: 400 KRCGNKIVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANC-SIGLCCHDCRFRPSGYVC 457
CGN VE E+CDCG ++C D CC S C+L+PGA C S G CC +C+ RPSG+ C
Sbjct: 422 AFCGNMFVEPGEQCDCGFLDDCV-DPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQC 480
Query: 458 RQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAM 516
R +CDL E+C G+SS CP DV DG PC + C C S QCQS++GP A
Sbjct: 481 RPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQ 540
Query: 517 EAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIS 576
A C N G+ FG+C ++ C ++ICG+LQC T P L ++
Sbjct: 541 PAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLW 600
Query: 577 THLQAENLMCWGTGYHLSM-KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLP 635
+ + HL + + P L + GT+CG G VC C +L
Sbjct: 601 ETIDVNGTELNCSWVHLDLGSDVAQPLLTL--PGTACGPGLVCIDHRCQRVDLLGAQECR 658
Query: 636 EKCNTRGVCNNRKNCHCMYGWAPPFC 661
KC+ GVC++ ++C+C GWAPP C
Sbjct: 659 SKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 284 bits (727), Expect = 2e-76
Identities = 218/773 (28%), Positives = 349/773 (45%), Gaps = 79/773 (10%)
Query: 17 LVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKL--------SFRGEVQGVVSPVSYLLQL 68
L+P LL S+ I G YEV P +L + + + + Y + +
Sbjct: 5 LLPVSLLLSVAVSAIKELPG-VKKYEVVYPIRLHPLHKREAKEPEQQEQFETELKYKMTI 63
Query: 69 KGKKHVLHLWP-KRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATIS 127
GK VL+L K LL P + + + G+ + P I DC Y G + S A+IS
Sbjct: 64 NGKIAVLYLKKNKNLLAPGYTETY-YNSTGKEITTSPQIMDDCYYQGHILNEKVSDASIS 122
Query: 128 TCMGGLRGVFNIDAKHYQIEPLKA--SPSFEHVVYLLKKEQFG-NQVCGLSDDEIEWQMA 184
TC G LRG F+ + Y IEPL EH ++ ++ + CG+ D + W
Sbjct: 123 TCRG-LRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKNYDSTCGM--DGVLWAHD 179
Query: 185 PYENKA-------RLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIM 237
+N A +L+D +H KY+E L+ D ++ N N ++ + +
Sbjct: 180 LQQNIALPATKLVKLKDRKVQ-EHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238
Query: 238 DTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYL 297
+ ++ + + L +E+WTD +KI++ P + L F ++ SVL+ R D A L
Sbjct: 239 NMLYKKLNTHVALVGMEIWTDKDKIKIT-PNASFTLENFSKWRGSVLSRRKRHDIAQLIT 297
Query: 298 QRKY-NDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCR 356
+ + +F Y+ V N+L A AHE+GH GM HD+ C+C
Sbjct: 298 ATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCP 357
Query: 357 GRLNCIMGSGR-----TGFSNCSYISFFKHISSG-ATCLNNIPGLGYVLKR--CGNKIVE 408
+ C+M T FS+CS +S+ K + CL N P ++ CGN++VE
Sbjct: 358 STI-CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVE 416
Query: 409 DNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAE 468
E+CDCG++EEC C CK++ C++G CC C+F+ +G VCR +ECDL E
Sbjct: 417 MGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECDLPE 476
Query: 469 YCDGNSSSCPNDVYKQDGTPCKY-EGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVN 527
C+G S +CP+D ++ +G PC + +G C C + QC ++GP A CY+ N
Sbjct: 477 MCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYNR-N 535
Query: 528 LIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCW 587
G ++G C C++ +++CG+L C +LP I+ T L +
Sbjct: 536 EGGSKYGYCRRVD-DTLIPCKANDTMCGKLFCQGGS--DNLPWKGRIV-TFLTCKTFDPE 591
Query: 588 GTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVN-SSVLQFDCLPEKCNTRGVCNN 646
T ++GM+ +GT CG+ +VC CV+ + KC VC++
Sbjct: 592 DTS----------QEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAVCDH 641
Query: 647 RKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFV 706
C C GW PP C++ S ++ SI++ +L ++V+FV
Sbjct: 642 ELQCQCEEGWIPPDCDD-------------------SSVVFHFSIVVG--VLFPMAVIFV 680
Query: 707 FFRQVI---GNHLKPKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAK 756
VI + K K+++ PLS T + K K + K QE S+ K
Sbjct: 681 VVAMVIRHQSSREKQKKDQRPLSTTGTRPHKQKRK--PQMVKAVQPQEMSQMK 731
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 278 bits (711), Expect = 1e-74
Identities = 211/738 (28%), Positives = 338/738 (45%), Gaps = 83/738 (11%)
Query: 15 LLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSP-------VSYLLQ 67
L L+ M+L ++ P + YEV +P +L + + S VSY+L
Sbjct: 6 LWLLGAMMLPAIAPS---RPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLG 62
Query: 68 LKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATIS 127
G LHL R LL +G + + P C Y G V+ DS A++S
Sbjct: 63 ATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLS 122
Query: 128 TCMGGLRGVFNIDAKHYQIEPL-KASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPY 186
TC GLRG F + + + IEPL + H VY + CG+SDD + + P
Sbjct: 123 TC-AGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGP- 180
Query: 187 ENKARLRDFPGSY---KHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQD 243
A R PG + +Y+EL ++ D + ++ + + + V H + + +D +Q
Sbjct: 181 RTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAA-VRHRVLEVVNHVDKLYQK 239
Query: 244 VRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYND 303
+ R+ L LE+W ++ V P+ + L + ++ R D L +
Sbjct: 240 LNFRVVLVGLEIWNSQDRFHVS-PDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTG 298
Query: 304 ALAWSFGKVCSL--EYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDE--QYCQCRGRL 359
F +V ++ +G+V+ N + A AHE+GH +GM HDE Q C+C+ R
Sbjct: 299 TTV-GFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERF 357
Query: 360 N---CIMGSGRTG------FSNCSYI---SFFKHISSGATCLNNIPGLGYVLKR--CGNK 405
CIM +G G FS+CS SF + S CL N P L +++ CGN
Sbjct: 358 EAGRCIM-AGSIGSSFPRMFSDCSQAYLESFLERPQS--VCLANAPDLSHLVGGPVCGNL 414
Query: 406 IVEDNEECDCGSTEECQKDRCCQS-NCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNEC 464
VE E+CDCG E+C ++RCC S C+L GA C+ G CC +C+ +P+G +CR + + C
Sbjct: 415 FVERGEQCDCGPPEDC-RNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMC 473
Query: 465 DLAEYCDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYD 524
DL E+CDG CP D ++++GTPC G C+ C + QCQ+ +GP A C+
Sbjct: 474 DLEEFCDGRHPECPEDAFQENGTPCS-GGYCYNGACPTLAQQCQAFWGPGGQAAEESCFS 532
Query: 525 AVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENL 584
D C+ + R +CG LQC + + L E+
Sbjct: 533 Y-----DILPGCKASRYR--------ADMCGVLQCKGGQQPLGRAICIVDVCHALTTED- 578
Query: 585 MCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVC 644
GT Y + +GT CG +VC+K C + V + +C+ GVC
Sbjct: 579 ---GTAYE------------PVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVC 623
Query: 645 NNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVV 704
N+++ CHC GWAPP C ++ S G++P + VV +++ ++L+ L+ +
Sbjct: 624 NHKQECHCHAGWAPPHCAKLLTEVHAAS-------GSLPVFV-VVVLVLLAVVLVTLAGI 675
Query: 705 FVFFR---QVIGNHLKPK 719
V+ + +++ ++ PK
Sbjct: 676 IVYRKARSRILSRNVAPK 693
>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
Length = 769
Score = 261 bits (667), Expect = 2e-69
Identities = 210/689 (30%), Positives = 318/689 (46%), Gaps = 91/689 (13%)
Query: 63 SYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDS 122
++ L L+ H+L + RH T+H DH C Y G ++ + S
Sbjct: 96 NFTLDLELNHHLL----SSQYVERHFSREGTTQHSTGAGDH------CYYQGKLRGNPHS 145
Query: 123 KATISTCMGGLRGVFNIDAKHYQIEPLKASPSF-------EHVVYL--LKKEQFGNQVCG 173
A +STC G L GVF+ Y +EP + + + H++Y L + G + G
Sbjct: 146 FAALSTCQG-LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPG 204
Query: 174 LSDDEIEWQMAPYENKARLR-------DFPGSYKHPKYLELILLFDQSRYRFVNNNLSQV 226
+ Q AP N+ RLR P + KY+ELI++ D + + ++
Sbjct: 205 CLF-AVPAQSAP-PNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLT 262
Query: 227 IHDAILLTGIMDT-YFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLN 285
+ A + + D Y + + RI L A+E W D +KI+V +L E L R ++Y++ L
Sbjct: 263 SNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQV-QDDLLETLARLMVYRREGLP 321
Query: 286 ARLSSDWAHLYLQRKYNDALAWS--FGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHA 343
SD HL+ R + + + G +CSL + G V+ N+ A A A LG
Sbjct: 322 E--PSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEY--GNMGAMAVTLAQTLGQN 377
Query: 344 VGMSHDEQY-----CQCRGR-LNCIMGSGRTGF------SNCSYISFFKHISSGA-TCLN 390
+GM ++ C+C L CIM TGF S CS + + + G +CL
Sbjct: 378 LGMMWNKHRSSAGDCKCPDIWLGCIMED--TGFYLPRKFSRCSIDEYNQFLQEGGGSCLF 435
Query: 391 NIPGLGYVLKRCGNKIVEDNEECDCGSTEECQK--DRCCQSNCKLQPGANCSIGLCCHDC 448
N P CGN VE EECDCGS +EC + CC+ C L A CS GLCC C
Sbjct: 436 NKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKK-CTLTHDAMCSDGLCCRRC 494
Query: 449 RFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCKYE-GRCFRKGCRSRYMQC 507
++ P G CR+ NECD+AE C G+SS CP +++K DG C +E GRC+ C++R QC
Sbjct: 495 KYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQC 554
Query: 508 QSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIP- 566
Q ++G A A CY+ +N+ G + G+C G + +C + +CG L C+N+ P
Sbjct: 555 QVLWGHAA--ADRFCYEKLNVEGTERGSCGRKG-SGWVQCSKQDVLCGFLLCVNISGAPR 611
Query: 567 --DLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCV 624
DL + ++ + Q + L C G L+ DL + DGT+CG +C C+
Sbjct: 612 LGDLVGDISSVTFYHQGKELDCRGGHVQLA----DGSDLSYVEDGTACGPNMLCLDHRCL 667
Query: 625 NSSVLQFDCLPEK-----CNTRGVCNNRKNCHCMYGW-------------APPFCEEVGY 666
+S F P C+ GVC+N C C W +PP E Y
Sbjct: 668 PASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERY 727
Query: 667 GGSIDSGPPG--LLRGAIPSSIWVVSIIM 693
GP G ++ G+I ++ V +I++
Sbjct: 728 -----KGPSGTNIIIGSIAGAVLVAAIVL 751
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 252 bits (643), Expect = 1e-66
Identities = 189/630 (30%), Positives = 297/630 (47%), Gaps = 62/630 (9%)
Query: 110 CNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKA-----SPSFEHVVYLLKK 164
C Y GS++ DSK +STC GL G+F D Y IEPL+ S H++
Sbjct: 196 CYYHGSIRGVKDSKVALSTC-NGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLA 254
Query: 165 EQFGNQVCGLSDD---------EIEWQMAPYENKARLRDFPGSYKHPKYLELILLFDQSR 215
Q+ Q+ L+ + E++W K + G ++ KYLEL+++ D
Sbjct: 255 GQYSKQMKNLTMERGDQWPFLSELQWLK---RRKRAVNPSRGIFEEMKYLELMIVNDHKT 311
Query: 216 YRFVNNNLSQVIHDAILLTGIMDT-YFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLG 274
Y+ ++ + + A + ++D+ Y + + R+ L A+E WT+ ++I + + ++L
Sbjct: 312 YKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPV-QMLH 370
Query: 275 RFVIYKKSVLNARLSSDWAHLYLQRKYN---DALAWSFGKVCSLEYAGSVST----LLDT 327
F Y++ + + +D HL + ++ +L++ FG VCS V+ +
Sbjct: 371 EFSKYRQRI---KQHADAVHLISRVTFHYKRSSLSY-FGGVCSRTRGVGVNEYGLPMAVA 426
Query: 328 NILAPATWSAHELGHAVGMSHDEQYCQCRGRLN-CIMG----SGRTGFSNCSYISFFKHI 382
+L+ + A LG S + C C CIM S FS CS + + +
Sbjct: 427 QVLSQSL--AQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFL 484
Query: 383 S-SGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSI 441
G CL N P + CGN VE EECDCG EC CC+ C L GA+CS
Sbjct: 485 QRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECY-GLCCKK-CSLSNGAHCSD 542
Query: 442 GLCCHD--CRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPC-KYEGRCFRK 498
G CC++ C F+P GY CR NECD+ EYC G+S CP +++KQDG C + +GRC+
Sbjct: 543 GPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNG 602
Query: 499 GCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQ 558
C++R QCQ I+G A + CY+ +N G + GNC G R + +C + CG L
Sbjct: 603 ECKTRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDR-WIQCSKHDVFCGFLL 661
Query: 559 CINVETIPDLPE-HTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRV 617
C N+ P + + II T + + +G H+ + D+G + DGT CG +
Sbjct: 662 CTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLD--DDTDVGYVEDGTPCGPSMM 719
Query: 618 CFKKNCVNSSVLQFDCLP-----EKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSI-- 670
C + C+ L P + C+ GVC+N C C + WA C ++
Sbjct: 720 CLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHP 779
Query: 671 --DSGPPG-----LLRGAIPSSIWVVSIIM 693
D GP G L+ G+I +I V +I++
Sbjct: 780 PKDEGPKGPSATNLIIGSIAGAILVAAIVL 809
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 249 bits (637), Expect = 5e-66
Identities = 183/594 (30%), Positives = 285/594 (47%), Gaps = 59/594 (9%)
Query: 110 CNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFE----HVVYLLKKE 165
C Y G ++ + DS +STC G L G+F Y IEP + + E H VY +
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLF 193
Query: 166 QFGN-------QVCGLSDDEIEWQMAPYENKARLRDFPGSYKHP-KYLELILLFDQSRYR 217
+F Q ++ + + P +K +LR +P + + KY+EL+++ D ++
Sbjct: 194 EFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFK 253
Query: 218 FVNNNLSQVIHD---AILLTGIMDTYFQD-VRMRIHLKALEVWTDFNKIRVGYPELAEVL 273
+ LS V+H A + + D ++D ++ RI L A+E W NK + L L
Sbjct: 254 --KHRLS-VVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLI-TL 309
Query: 274 GRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWS--FGKVCSLEYAGSVSTLLDTNILA 331
F+ Y++ + + SD HL+ ++ + + + G +CSL G V+ T+++A
Sbjct: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMA 367
Query: 332 PATWSAHELGHAVGMSHDEQY-----CQCRGRLN-CIMGSGRTG------FSNCSYISFF 379
A L H +G+ D++ C+C + CIMG TG F+ C+ +
Sbjct: 368 VTL--AQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGD--TGYYLPKKFTQCNIEEYH 423
Query: 380 KHISSGA-TCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKD--RCCQSNCKLQPG 436
++SG CL N P CGN +E EECDCG+ EC + CC+ C L
Sbjct: 424 DFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK-CTLTQD 482
Query: 437 ANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRC 495
+ CS GLCC C+F+P G VCR+ N+CD+ E C GNSS C +++K DG C +G C
Sbjct: 483 SQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGIC 542
Query: 496 FRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICG 555
F C++R QC+ I+G + CY+ +N+ G + GNC + +C + +CG
Sbjct: 543 FGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCG-KDKDTWIQCNKRDVLCG 601
Query: 556 RLQCINVETIPDLPEHTTIISTHL---QAENLMCWGTGYHLSMKPMGIPDLGMINDGTSC 612
L C N+ IP L E I++ L Q L C +G H+ ++ DLG + DGT C
Sbjct: 602 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNC--SGGHVKLEE--DVDLGYVEDGTPC 657
Query: 613 GEGRVCFKKNCVNSSVLQFD-CLPEK----CNTRGVCNNRKNCHCMYGWAPPFC 661
G +C + C+ + F CL K C+ GVC+N C C W C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 249 bits (637), Expect = 5e-66
Identities = 183/594 (30%), Positives = 285/594 (47%), Gaps = 59/594 (9%)
Query: 110 CNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFE----HVVYLLKKE 165
C Y G ++ + DS +STC G L G+F Y IEP + + E H VY +
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLF 193
Query: 166 QFGN-------QVCGLSDDEIEWQMAPYENKARLRDFPGSYKHP-KYLELILLFDQSRYR 217
+F Q ++ + + P +K +LR +P + + KY+EL+++ D ++
Sbjct: 194 EFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFK 253
Query: 218 FVNNNLSQVIHD---AILLTGIMDTYFQD-VRMRIHLKALEVWTDFNKIRVGYPELAEVL 273
+ LS V+H A + + D ++D ++ RI L A+E W NK + L L
Sbjct: 254 --KHRLS-VVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLI-TL 309
Query: 274 GRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWS--FGKVCSLEYAGSVSTLLDTNILA 331
F+ Y++ + + SD HL+ ++ + + + G +CSL G V+ T+++A
Sbjct: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMA 367
Query: 332 PATWSAHELGHAVGMSHDEQY-----CQCRGRLN-CIMGSGRTG------FSNCSYISFF 379
A L H +G+ D++ C+C + CIMG TG F+ C+ +
Sbjct: 368 VTL--AQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGD--TGYYLPKKFTQCNIEEYH 423
Query: 380 KHISSGA-TCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKD--RCCQSNCKLQPG 436
++SG CL N P CGN +E EECDCG+ EC + CC+ C L
Sbjct: 424 DFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK-CTLTQD 482
Query: 437 ANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRC 495
+ CS GLCC C+F+P G VCR+ N+CD+ E C GNSS C +++K DG C +G C
Sbjct: 483 SQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGIC 542
Query: 496 FRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICG 555
F C++R QC+ I+G + CY+ +N+ G + GNC + +C + +CG
Sbjct: 543 FGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCG-KDKDTWIQCNKRDVLCG 601
Query: 556 RLQCINVETIPDLPEHTTIISTHL---QAENLMCWGTGYHLSMKPMGIPDLGMINDGTSC 612
L C N+ IP L E I++ L Q L C +G H+ ++ DLG + DGT C
Sbjct: 602 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNC--SGGHVKLEE--DVDLGYVEDGTPC 657
Query: 613 GEGRVCFKKNCVNSSVLQFD-CLPEK----CNTRGVCNNRKNCHCMYGWAPPFC 661
G +C + C+ + F CL K C+ GVC+N C C W C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 249 bits (637), Expect = 5e-66
Identities = 183/594 (30%), Positives = 285/594 (47%), Gaps = 59/594 (9%)
Query: 110 CNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFE----HVVYLLKKE 165
C Y G ++ + DS +STC G L G+F Y IEP + + E H VY +
Sbjct: 135 CYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLF 193
Query: 166 QFGN-------QVCGLSDDEIEWQMAPYENKARLRDFPGSYKHP-KYLELILLFDQSRYR 217
+F Q ++ + + P +K +LR +P + + KY+EL+++ D ++
Sbjct: 194 EFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFK 253
Query: 218 FVNNNLSQVIHD---AILLTGIMDTYFQD-VRMRIHLKALEVWTDFNKIRVGYPELAEVL 273
+ LS V+H A + + D ++D ++ RI L A+E W NK + L L
Sbjct: 254 --KHRLS-VVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLI-TL 309
Query: 274 GRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWS--FGKVCSLEYAGSVSTLLDTNILA 331
F+ Y++ + + SD HL+ ++ + + + G +CSL G V+ T+++A
Sbjct: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMA 367
Query: 332 PATWSAHELGHAVGMSHDEQY-----CQCRGRLN-CIMGSGRTG------FSNCSYISFF 379
A L H +G+ D++ C+C + CIMG TG F+ C+ +
Sbjct: 368 VTL--AQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGD--TGYYLPKKFTQCNIEEYH 423
Query: 380 KHISSGA-TCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKD--RCCQSNCKLQPG 436
++SG CL N P CGN +E EECDCG+ EC + CC+ C L
Sbjct: 424 DFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK-CTLTQD 482
Query: 437 ANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRC 495
+ CS GLCC C+F+P G VCR+ N+CD+ E C GNSS C +++K DG C +G C
Sbjct: 483 SQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGIC 542
Query: 496 FRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICG 555
F C++R QC+ I+G + CY+ +N+ G + GNC + +C + +CG
Sbjct: 543 FGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCG-KDKDTWIQCNKRDVLCG 601
Query: 556 RLQCINVETIPDLPEHTTIISTHL---QAENLMCWGTGYHLSMKPMGIPDLGMINDGTSC 612
L C N+ IP L E I++ L Q L C +G H+ ++ DLG + DGT C
Sbjct: 602 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNC--SGGHVKLEE--DVDLGYVEDGTPC 657
Query: 613 GEGRVCFKKNCVNSSVLQFD-CLPEK----CNTRGVCNNRKNCHCMYGWAPPFC 661
G +C + C+ + F CL K C+ GVC+N C C W C
Sbjct: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,046,011
Number of Sequences: 37866
Number of extensions: 1651574
Number of successful extensions: 10647
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 177
Number of HSP's successfully gapped in prelim test: 264
Number of HSP's that attempted gapping in prelim test: 7432
Number of HSP's gapped (non-prelim): 2519
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.