Search of human proteins with 28416925

Search of human proteins with 28416925

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28416925 purinergic receptor P2X3 [Homo sapiens]
         (397 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28416925 purinergic receptor P2X3 [Homo sapiens]                   808   0.0  
gi|28416927 purinergic receptor P2X4 [Homo sapiens]                   344   7e-95
gi|28416923 purinergic receptor P2X2 isoform B [Homo sapiens]         336   2e-92
gi|25092719 purinergic receptor P2X2 isoform A [Homo sapiens]         336   2e-92
gi|25092733 purinergic receptor P2X2 isoform D [Homo sapiens]         322   5e-88
gi|4505545 purinergic receptor P2X1 [Homo sapiens]                    319   3e-87
gi|28416933 purinergic receptor P2X5 isoform A [Homo sapiens]         308   7e-84
gi|7706629 purinergic receptor P2X2 isoform C [Homo sapiens]          301   9e-82
gi|157419148 purinergic receptor P2X6 isoform 1 [Homo sapiens]        284   9e-77
gi|28416935 purinergic receptor P2X5 isoform B [Homo sapiens]         268   8e-72
gi|227116341 purinergic receptor P2X6 isoform 2 [Homo sapiens]        256   2e-68
gi|29294631 purinergic receptor P2X7 [Homo sapiens]                   255   4e-68
gi|28416921 purinergic receptor P2X2 isoform H [Homo sapiens]         236   2e-62
gi|27881423 purinergic receptor P2X2 isoform I [Homo sapiens]         228   7e-60
gi|28416937 purinergic receptor P2X5 isoform C [Homo sapiens]         131   1e-30
gi|55749678 ninein-like [Homo sapiens]                                 30   5.0  
gi|122937420 plasma kallikrein-like protein 4 [Homo sapiens]           29   8.5  

>gi|28416925 purinergic receptor P2X3 [Homo sapiens]
          Length = 397

 Score =  808 bits (2087), Expect = 0.0
 Identities = 397/397 (100%), Positives = 397/397 (100%)

Query: 1   MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV 60
           MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
Sbjct: 1   MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV 60

Query: 61  VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS 120
           VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
Sbjct: 61  VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS 120

Query: 121 QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR 180
           QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
Sbjct: 121 QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR 180

Query: 181 FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG 240
           FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
Sbjct: 181 FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG 240

Query: 241 IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA 300
           IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
Sbjct: 241 IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA 300

Query: 301 FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE 360
           FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
Sbjct: 301 FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE 360

Query: 361 VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH 397
           VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
Sbjct: 361 VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH 397


>gi|28416927 purinergic receptor P2X4 [Homo sapiens]
          Length = 388

 Score =  344 bits (883), Expect = 7e-95
 Identities = 171/366 (46%), Positives = 246/366 (67%), Gaps = 11/366 (3%)

Query: 8   FTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGS 67
           F Y+T + V+++S  +G++NR VQLLI++Y +GWVF+ EK YQ  D+ + SSV TKVKG 
Sbjct: 13  FEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVV-SSVTTKVKGV 71

Query: 68  GLYAN-----RVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYR-CVSDSQ 121
            +        R+ DV+DYV P Q  +   ++T +I+T NQ QG CPE  +    C SD+ 
Sbjct: 72  AVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDAS 131

Query: 122 C--GPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDT-VETPIMMEA-ENFTIFIKN 177
           C  G       G+ TGRCV ++  ++TCE+  WCP E DT V  P  ++A ENFT+ +KN
Sbjct: 132 CTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKN 191

Query: 178 SIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGG 237
           +I +P FNF K N+LPN+T   +K+C +    DPFCPI R+G +V+ AG  F  +A  GG
Sbjct: 192 NIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGG 251

Query: 238 VLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTL 297
           ++GI++ W C+LD+A   C+P+YSF RLD+   + +VSPGYNFRFAKYY+   G+E RTL
Sbjct: 252 IMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTL 311

Query: 298 LKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKK 357
           +KA+GIRFD++V+G AGKF+IIPT+I+  +    +G+ TVLCDII+L  +K    Y+ KK
Sbjct: 312 IKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKK 371

Query: 358 FEEVNE 363
           ++ V +
Sbjct: 372 YKYVED 377


>gi|28416923 purinergic receptor P2X2 isoform B [Homo sapiens]
          Length = 404

 Score =  336 bits (862), Expect = 2e-92
 Identities = 181/368 (49%), Positives = 243/368 (66%), Gaps = 10/368 (2%)

Query: 3   CISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVT 62
           C S  + YET K +VV++  +G++ R VQLLI+ YFV +VF+ +K+YQ  +T  ESS++T
Sbjct: 21  CWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIIT 80

Query: 63  KVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYR--CVSDS 120
           KVKG     ++V DV +YV PP+G SVF IIT++  T +Q QG CPES   +   C+SD+
Sbjct: 81  KVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDA 140

Query: 121 QC--GPERLPGGGILTGRCV-NYSSVLRTCEIQGWCPTEVD-TVETPIMMEAENFTIFIK 176
            C  G   + G G+ TGRCV  Y    +TCE+ GWCP E   +V   +   A NFTI IK
Sbjct: 141 DCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIK 200

Query: 177 NSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTG 236
           NSI +P F+F KGN + + T   +K C FH   D +CPI ++G +V+ AG+ F +LA  G
Sbjct: 201 NSIHYPKFHFSKGN-IADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKG 259

Query: 237 GVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRT 296
           GV+G+ I W CDLD    +C PKYSF RLD   +    S GYNFRFAKYYK+ NG+  RT
Sbjct: 260 GVIGVIINWDCDLDLPASECNPKYSFRRLD--PKHVPASSGYNFRFAKYYKI-NGTTTRT 316

Query: 297 LLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAK 356
           L+KA+GIR DV+V+G AGKF++IPTII+   A TSVGVG+ LCD ILL F+     Y  K
Sbjct: 317 LIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHK 376

Query: 357 KFEEVNET 364
           KF+++ +T
Sbjct: 377 KFDKMVDT 384


>gi|25092719 purinergic receptor P2X2 isoform A [Homo sapiens]
          Length = 471

 Score =  336 bits (861), Expect = 2e-92
 Identities = 181/365 (49%), Positives = 241/365 (66%), Gaps = 10/365 (2%)

Query: 3   CISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVT 62
           C S  + YET K +VV++  +G++ R VQLLI+ YFV +VF+ +K+YQ  +T  ESS++T
Sbjct: 21  CWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIIT 80

Query: 63  KVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYR--CVSDS 120
           KVKG     ++V DV +YV PP+G SVF IIT++  T +Q QG CPES   +   C+SD+
Sbjct: 81  KVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDA 140

Query: 121 QC--GPERLPGGGILTGRCV-NYSSVLRTCEIQGWCPTEVD-TVETPIMMEAENFTIFIK 176
            C  G   + G G+ TGRCV  Y    +TCE+ GWCP E   +V   +   A NFTI IK
Sbjct: 141 DCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIK 200

Query: 177 NSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTG 236
           NSI +P F+F KGN + + T   +K C FH   D +CPI ++G +V+ AG+ F +LA  G
Sbjct: 201 NSIHYPKFHFSKGN-IADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKG 259

Query: 237 GVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRT 296
           GV+G+ I W CDLD    +C PKYSF RLD   +    S GYNFRFAKYYK+ NG+  RT
Sbjct: 260 GVIGVIINWDCDLDLPASECNPKYSFRRLD--PKHVPASSGYNFRFAKYYKI-NGTTTRT 316

Query: 297 LLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAK 356
           L+KA+GIR DV+V+G AGKF++IPTII+   A TSVGVG+ LCD ILL F+     Y  K
Sbjct: 317 LIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHK 376

Query: 357 KFEEV 361
           KF++V
Sbjct: 377 KFDKV 381


>gi|25092733 purinergic receptor P2X2 isoform D [Homo sapiens]
          Length = 497

 Score =  322 bits (824), Expect = 5e-88
 Identities = 181/391 (46%), Positives = 241/391 (61%), Gaps = 36/391 (9%)

Query: 3   CISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVT 62
           C S  + YET K +VV++  +G++ R VQLLI+ YFV +VF+ +K+YQ  +T  ESS++T
Sbjct: 21  CWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIIT 80

Query: 63  KVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYR--CVSDS 120
           KVKG     ++V DV +YV PP+G SVF IIT++  T +Q QG CPES   +   C+SD+
Sbjct: 81  KVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDA 140

Query: 121 QC--GPERLPGGGILTGRCV-NYSSVLRTCEIQGWCPTEVD-TVETPIMMEAENFTIFIK 176
            C  G   + G G+ TGRCV  Y    +TCE+ GWCP E   +V   +   A NFTI IK
Sbjct: 141 DCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIK 200

Query: 177 NSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTG 236
           NSI +P F+F KGN + + T   +K C FH   D +CPI ++G +V+ AG+ F +LA  G
Sbjct: 201 NSIHYPKFHFSKGN-IADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKG 259

Query: 237 GVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRT 296
           GV+G+ I W CDLD    +C PKYSF RLD   +    S GYNFRFAKYYK+ NG+  RT
Sbjct: 260 GVIGVIINWDCDLDLPASECNPKYSFRRLD--PKHVPASSGYNFRFAKYYKI-NGTTTRT 316

Query: 297 LLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGV---------------------- 334
           L+KA+GIR DV+V+G AGKF++IPTII+   A TSVGV                      
Sbjct: 317 LIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVVRNPLWGPSGCGGSTRPLHTGL 376

Query: 335 ----GTVLCDIILLNFLKGADQYKAKKFEEV 361
               G+ LCD ILL F+     Y  KKF++V
Sbjct: 377 CWPQGSFLCDWILLTFMNKNKVYSHKKFDKV 407


>gi|4505545 purinergic receptor P2X1 [Homo sapiens]
          Length = 399

 Score =  319 bits (817), Expect = 3e-87
 Identities = 169/361 (46%), Positives = 231/361 (63%), Gaps = 14/361 (3%)

Query: 8   FTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGS 67
           F Y+T + V+V++  +G+I R++QL+++ Y +GWVFL+EK YQ     I SSV  K+KG 
Sbjct: 14  FEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLI-SSVSVKLKGL 72

Query: 68  GL-----YANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQC 122
            +        +V DV+DYV P QG + FV++T  IVT  Q QG+C E  E   C  DS C
Sbjct: 73  AVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGGICKEDSGC 132

Query: 123 GPERLP--GGGILTGRCVNYSSVLRTCEIQGWCPTEVDT-VETPIMM-EAENFTIFIKNS 178
            P +      GI TG+CV ++  ++TCEI GWCP EVD  +  P ++ EAENFT+FIKNS
Sbjct: 133 TPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTLFIKNS 192

Query: 179 IRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGV 238
           I FP F   + NL+  + A  MKTC FH    P CP+ ++G VV+ +GQ+F+ LA  GGV
Sbjct: 193 ISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGV 252

Query: 239 LGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLL 298
           +GI I W CDLD     C P Y F     + E+ ++SPG+NFRFA+++ +ENG+ YR L 
Sbjct: 253 VGITIDWHCDLDWHVRHCRPIYEF---HGLYEEKNLSPGFNFRFARHF-VENGTNYRHLF 308

Query: 299 KAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKF 358
           K FGIRFD+LV G AGKF+IIPT+ +  +     GV TVLCD++LL+ L     YK KKF
Sbjct: 309 KVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKF 368

Query: 359 E 359
           +
Sbjct: 369 K 369


>gi|28416933 purinergic receptor P2X5 isoform A [Homo sapiens]
          Length = 422

 Score =  308 bits (788), Expect = 7e-84
 Identities = 168/370 (45%), Positives = 227/370 (61%), Gaps = 36/370 (9%)

Query: 3   CISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVT 62
           C+S  F Y+T K V+ K+  +G++ R++Q  I++Y V WVFL +K YQ  DT+++S+V+T
Sbjct: 10  CLS-LFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVIT 68

Query: 63  KVKGSGL-----YANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESE--EKYR 115
           KVKG           R+ DV+DYV P QG +VF ++T +IVT NQ Q  C E+E      
Sbjct: 69  KVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGA 128

Query: 116 CVSDSQC--GPERLPGGGILTGRCVNYSSVLR-TCEIQGWCPTEVDT-VETPIMMEAENF 171
           C  DS C  G     G G+ TGRC+   ++ R TCEI  WCP E  +  E P + EAE+F
Sbjct: 129 CSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDF 188

Query: 172 TIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAK 231
           TIFIKN IRFP FNF K N++       +K+C F P K+ +CPI R+G V+++AG DF  
Sbjct: 189 TIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGP-KNHYCPIFRLGSVIRWAGSDFQD 247

Query: 232 LARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENG 291
           +A  GGV+GI I W CDLDKA  +C P YSF+RLD+   K SVS GYNFRFA+YY+   G
Sbjct: 248 IALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSK-SVSSGYNFRFARYYRDAAG 306

Query: 292 SEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGAD 351
            E+RTL+KA+GIRFDV+V G                       G   CD++L+  +K  +
Sbjct: 307 VEFRTLMKAYGIRFDVMVNGK----------------------GAFFCDLVLIYLIKKRE 344

Query: 352 QYKAKKFEEV 361
            Y+ KK+EEV
Sbjct: 345 FYRDKKYEEV 354


>gi|7706629 purinergic receptor P2X2 isoform C [Homo sapiens]
          Length = 447

 Score =  301 bits (770), Expect = 9e-82
 Identities = 167/363 (46%), Positives = 222/363 (61%), Gaps = 30/363 (8%)

Query: 3   CISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVT 62
           C S  + YET K +VV++  +G++ R VQLLI+ YFV +VF+ +K+YQ  +T  ESS++T
Sbjct: 21  CWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIIT 80

Query: 63  KVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQC 122
           KVKG     ++V DV +YV PP+   V                          C+SD+ C
Sbjct: 81  KVKGITTSEHKVWDVEEYVKPPESIRV----------------------HNATCLSDADC 118

Query: 123 --GPERLPGGGILTGRCVNY-SSVLRTCEIQGWCPTEVD-TVETPIMMEAENFTIFIKNS 178
             G   + G G+ TGRCV Y     +TCE+ GWCP E   +V   +   A NFTI IKNS
Sbjct: 119 VAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNS 178

Query: 179 IRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGV 238
           I +P F+F KGN+    T   +K C FH   D +CPI ++G +V+ AG+ F +LA  GGV
Sbjct: 179 IHYPKFHFSKGNIADR-TDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGV 237

Query: 239 LGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLL 298
           +G+ I W CDLD    +C PKYSF RLD   +    S GYNFRFAKYYK+ NG+  RTL+
Sbjct: 238 IGVIINWDCDLDLPASECNPKYSFRRLDP--KHVPASSGYNFRFAKYYKI-NGTTTRTLI 294

Query: 299 KAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKF 358
           KA+GIR DV+V+G AGKF++IPTII+   A TSVGVG+ LCD ILL F+     Y  KKF
Sbjct: 295 KAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKF 354

Query: 359 EEV 361
           ++V
Sbjct: 355 DKV 357


>gi|157419148 purinergic receptor P2X6 isoform 1 [Homo sapiens]
          Length = 441

 Score =  284 bits (727), Expect = 9e-77
 Identities = 155/362 (42%), Positives = 212/362 (58%), Gaps = 21/362 (5%)

Query: 10  YETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGL 69
           Y+T K V+ ++W +G + R++Q  I+ Y VGW  L +K YQ RD   + S++TK+KG  +
Sbjct: 25  YKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSV 84

Query: 70  -----YANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPE--SEEKYRCVSDSQC 122
                  NR+ DV+D+V PPQG +VF ++T  +VT  Q+QG CPE  S     C  D  C
Sbjct: 85  TQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWVDEDC 144

Query: 123 GPERLPGG---GILTGRCVNYSSVLRTCEIQGWCPTEVDTVET-PIMMEAENFTIFIKNS 178
            PE   G    G+ TG+CV ++   RTCEI  WCP E   V + P++ +A+NFT+FIKN+
Sbjct: 145 -PEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVVPSRPLLAQAQNFTLFIKNT 203

Query: 179 IRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGV 238
           + F  FNF K N L        K CR+ P   P+CP+ R+GD+V  AG  F  LA  GG 
Sbjct: 204 VTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGDLVAKAGGTFEDLALLGGS 263

Query: 239 LGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLL 298
           +GI++ W CDLD     C P YSF     + EKS     YNFR A ++  + G E RTLL
Sbjct: 264 VGIRVHWDCDLDTGDSGCWPHYSF----QLQEKS-----YNFRTATHWWEQPGVEARTLL 314

Query: 299 KAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKF 358
           K +GIRFD+LV G AGKF +IPT ++       +GV T  CD++LL   + A  Y   K+
Sbjct: 315 KLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFYWRTKY 374

Query: 359 EE 360
           EE
Sbjct: 375 EE 376


>gi|28416935 purinergic receptor P2X5 isoform B [Homo sapiens]
          Length = 397

 Score =  268 bits (684), Expect = 8e-72
 Identities = 154/366 (42%), Positives = 210/366 (57%), Gaps = 53/366 (14%)

Query: 3   CISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVT 62
           C+S  F Y+T K V+ K+  +G++ R++Q  I++Y V WVFL +K YQ  DT+++S+V+T
Sbjct: 10  CLS-LFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVIT 68

Query: 63  KVKGSGL-----YANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCV 117
           KVKG           R+ DV+DYV P Q   +               G C +        
Sbjct: 69  KVKGVAFTNTSDLGQRIWDVADYVIPAQNEGI-------------PDGACSKD------- 108

Query: 118 SDSQCGPERLPGGGILTGRCVNYSSVLR-TCEIQGWCPTEVDT-VETPIMMEAENFTIFI 175
           SD   G     G G+ TGRC+   ++ R TCEI  WCP E  +  E P + EAE+FTIFI
Sbjct: 109 SDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFI 168

Query: 176 KNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLART 235
           KN IRFP FNF   N++       +K+C F P K+ +CPI R+G V+++AG DF  +A  
Sbjct: 169 KNHIRFPKFNFSN-NVMDVKDRSFLKSCHFGP-KNHYCPIFRLGSVIRWAGSDFQDIALE 226

Query: 236 GGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYR 295
           GGV+GI I W CDLDKA  +C P YSF+RLD+   K SVS GYNFRFA+YY+   G E+R
Sbjct: 227 GGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSK-SVSSGYNFRFARYYRDAAGVEFR 285

Query: 296 TLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKA 355
           TL+KA+GIRFDV+V G                       G   CD++L+  +K  + Y+ 
Sbjct: 286 TLMKAYGIRFDVMVNGK----------------------GAFFCDLVLIYLIKKREFYRD 323

Query: 356 KKFEEV 361
           KK+EEV
Sbjct: 324 KKYEEV 329


>gi|227116341 purinergic receptor P2X6 isoform 2 [Homo sapiens]
          Length = 415

 Score =  256 bits (655), Expect = 2e-68
 Identities = 143/331 (43%), Positives = 191/331 (57%), Gaps = 21/331 (6%)

Query: 41  WVFLHEKAYQVRDTAIESSVVTKVKGSGL-----YANRVMDVSDYVTPPQGTSVFVIITK 95
           W  L +K YQ RD   + S++TK+KG  +       NR+ DV+D+V PPQG +VF ++T 
Sbjct: 30  WALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTN 89

Query: 96  MIVTENQMQGFCPE--SEEKYRCVSDSQCGPERLPGG---GILTGRCVNYSSVLRTCEIQ 150
            +VT  Q+QG CPE  S     C  D  C PE   G    G+ TG+CV ++   RTCEI 
Sbjct: 90  FLVTPAQVQGRCPEHPSVPLANCWVDEDC-PEGEGGTHSHGVKTGQCVVFNGTHRTCEIW 148

Query: 151 GWCPTEVDTVET-PIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDK 209
            WCP E   V + P++ +A+NFT+FIKN++ F  FNF K N L        K CR+ P  
Sbjct: 149 SWCPVESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQF 208

Query: 210 DPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVS 269
            P+CP+ R+GD+V  AG  F  LA  GG +GI++ W CDLD     C P YSF     + 
Sbjct: 209 SPYCPVFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSF----QLQ 264

Query: 270 EKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAF 329
           EKS     YNFR A ++  + G E RTLLK +GIRFD+LV G AGKF +IPT ++     
Sbjct: 265 EKS-----YNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGA 319

Query: 330 TSVGVGTVLCDIILLNFLKGADQYKAKKFEE 360
             +GV T  CD++LL   + A  Y   K+EE
Sbjct: 320 AWLGVVTFFCDLLLLYVDREAHFYWRTKYEE 350


>gi|29294631 purinergic receptor P2X7 [Homo sapiens]
          Length = 595

 Score =  255 bits (652), Expect = 4e-68
 Identities = 151/356 (42%), Positives = 204/356 (57%), Gaps = 25/356 (7%)

Query: 5   SDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKV 64
           SD F YET K   ++S   G I     ++I SY V +  + +K YQ ++  I SSV TKV
Sbjct: 8   SDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSY-VCFALVSDKLYQRKEPVI-SSVHTKV 65

Query: 65  KG----------SGL--YANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPE-SE 111
           KG          +G+    + V D +DY  P QG S FV+ T  + TE Q Q  CPE   
Sbjct: 66  KGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVM-TNFLKTEGQEQRLCPEYPT 124

Query: 112 EKYRCVSDSQC--GPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTE-VDTVETPIMME- 167
            +  C SD  C  G       GI TGRCV Y    +TCE+  WCP E V+    P ++  
Sbjct: 125 RRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNS 184

Query: 168 AENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQ 227
           AENFT+ IKN+I FP  N+   N+LP L      TC FH  ++P CPI R+GD+ +  G 
Sbjct: 185 AENFTVLIKNNIDFPGHNYTTRNILPGLNI----TCTFHKTQNPQCPIFRLGDIFRETGD 240

Query: 228 DFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYK 287
           +F+ +A  GG++GI+I W C+LD+ +  C PKYSF RLD  +   S+ PGYNFR+AKYYK
Sbjct: 241 NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK 300

Query: 288 MENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIIL 343
            EN  E RTL+K FGIRFD+LV+G  GKF+II  ++   +  +  G+  V  D ++
Sbjct: 301 -ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLI 355


>gi|28416921 purinergic receptor P2X2 isoform H [Homo sapiens]
          Length = 379

 Score =  236 bits (603), Expect = 2e-62
 Identities = 127/250 (50%), Positives = 163/250 (65%), Gaps = 8/250 (3%)

Query: 116 CVSDSQC--GPERLPGGGILTGRCVNY-SSVLRTCEIQGWCPTEVD-TVETPIMMEAENF 171
           C+SD+ C  G   + G G+ TGRCV Y     +TCE+ GWCP E   +V   +   A NF
Sbjct: 44  CLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNF 103

Query: 172 TIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAK 231
           TI IKNSI +P F+F KGN+    T   +K C FH   D +CPI ++G +V+ AG+ F +
Sbjct: 104 TILIKNSIHYPKFHFSKGNIADR-TDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTE 162

Query: 232 LARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENG 291
           LA  GGV+G+ I W CDLD    +C PKYSF RLD   +    S GYNFRFAKYYK+ NG
Sbjct: 163 LAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDP--KHVPASSGYNFRFAKYYKI-NG 219

Query: 292 SEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGAD 351
           +  RTL+KA+GIR DV+V+G AGKF++IPTII+   A TSVGVG+ LCD ILL F+    
Sbjct: 220 TTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNK 279

Query: 352 QYKAKKFEEV 361
            Y  KKF++V
Sbjct: 280 VYSHKKFDKV 289


>gi|27881423 purinergic receptor P2X2 isoform I [Homo sapiens]
          Length = 399

 Score =  228 bits (581), Expect = 7e-60
 Identities = 121/233 (51%), Positives = 154/233 (66%), Gaps = 6/233 (2%)

Query: 131 GILTGRCVNY-SSVLRTCEIQGWCPTEVD-TVETPIMMEAENFTIFIKNSIRFPLFNFEK 188
           G+ TGRCV Y     +TCE+ GWCP E   +V   +   A NFTI IKNSI +P F+F K
Sbjct: 81  GLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSK 140

Query: 189 GNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCD 248
           GN+    T   +K C FH   D +CPI ++G +V+ AG+ F +LA  GGV+G+ I W CD
Sbjct: 141 GNIADR-TDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCD 199

Query: 249 LDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVL 308
           LD    +C PKYSF RLD   +    S GYNFRFAKYYK+ NG+  RTL+KA+GIR DV+
Sbjct: 200 LDLPASECNPKYSFRRLDP--KHVPASSGYNFRFAKYYKI-NGTTTRTLIKAYGIRIDVI 256

Query: 309 VYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEV 361
           V+G AGKF++IPTII+   A TSVGVG+ LCD ILL F+     Y  KKF++V
Sbjct: 257 VHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKV 309


>gi|28416937 purinergic receptor P2X5 isoform C [Homo sapiens]
          Length = 178

 Score =  131 bits (329), Expect = 1e-30
 Identities = 71/167 (42%), Positives = 100/167 (59%), Gaps = 11/167 (6%)

Query: 3   CISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVT 62
           C+S  F Y+T K V+ K+  +G++ R++Q  I++Y V WVFL +K YQ  DT+++S+V+T
Sbjct: 10  CLS-LFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVIT 68

Query: 63  KVKGSGL-----YANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESE--EKYR 115
           KVKG           R+ DV+DYV P QG +VF ++T +IVT NQ Q  C E+E      
Sbjct: 69  KVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGA 128

Query: 116 CVSDSQC--GPERLPGGGILTGRCVNYSSVLR-TCEIQGWCPTEVDT 159
           C  DS C  G     G G+ TGRC+   ++ R TCEI  WCP E  +
Sbjct: 129 CSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSS 175


>gi|55749678 ninein-like [Homo sapiens]
          Length = 1382

 Score = 29.6 bits (65), Expect = 5.0
 Identities = 16/51 (31%), Positives = 25/51 (49%)

Query: 342 ILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGA 392
           +LL  L G D +    FEE  E  + + +    V PSD+ ++  +S  S A
Sbjct: 47  VLLQTLLGNDHFARVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSA 97


>gi|122937420 plasma kallikrein-like protein 4 [Homo sapiens]
          Length = 395

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 18/81 (22%), Positives = 31/81 (38%), Gaps = 3/81 (3%)

Query: 135 GRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPN 194
           GR ++   VL+ C + GW PT        + +  +   IF+K+    PL+  +K     +
Sbjct: 152 GRMLHTPPVLQNCWVSGWNPTSATGNHMTMSVLRK---IFVKDLDMCPLYKLQKTECGSH 208

Query: 195 LTARDMKTCRFHPDKDPFCPI 215
                   C   P     C +
Sbjct: 209 TKEETKTACLGDPGSPMMCQL 229


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,426,682
Number of Sequences: 37866
Number of extensions: 620038
Number of successful extensions: 1276
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 1188
Number of HSP's gapped (non-prelim): 17
length of query: 397
length of database: 18,247,518
effective HSP length: 104
effective length of query: 293
effective length of database: 14,309,454
effective search space: 4192670022
effective search space used: 4192670022
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.