Search of human proteins with 24497587

Search of human proteins with 24497587

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24497587 adenylate cyclase 4 [Homo sapiens]
         (1077 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24497587 adenylate cyclase 4 [Homo sapiens]                       2156   0.0  
gi|115387102 adenylate cyclase 2 [Homo sapiens]                      1187   0.0  
gi|4557255 adenylate cyclase 7 [Homo sapiens]                        1016   0.0  
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]              649   0.0  
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]              643   0.0  
gi|34486092 adenylate cyclase 5 [Homo sapiens]                        634   0.0  
gi|4557257 adenylate cyclase 8 [Homo sapiens]                         595   e-170
gi|31083193 adenylate cyclase 1 [Homo sapiens]                        594   e-169
gi|148536830 adenylate cyclase 3 [Homo sapiens]                       552   e-157
gi|50959205 adenylate cyclase 9 [Homo sapiens]                        393   e-109
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho...   122   1e-27
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   122   1e-27
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   122   1e-27
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom...   122   1e-27
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho...   122   1e-27
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]    120   7e-27
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho...   120   7e-27
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]            114   5e-25
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]       113   8e-25
gi|134152694 guanylate cyclase 2F [Homo sapiens]                      110   5e-24
gi|222080083 guanylate cyclase 2C [Homo sapiens]                      110   7e-24
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom...   107   8e-23
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]         99   2e-20
gi|209976994 adenylate cyclase 10 [Homo sapiens]                       40   0.009
gi|4507381 thromboxane A2 receptor [Homo sapiens]                      35   0.50 
gi|30581164 neuropeptides B/W receptor 2 [Homo sapiens]                32   3.2  
gi|28872720 purinergic receptor P2Y2 [Homo sapiens]                    32   4.2  
gi|28872745 purinergic receptor P2Y2 [Homo sapiens]                    32   4.2  
gi|28872743 purinergic receptor P2Y2 [Homo sapiens]                    32   4.2  
gi|8923657 solute carrier family 35, member A5 [Homo sapiens]          32   4.2  

>gi|24497587 adenylate cyclase 4 [Homo sapiens]
          Length = 1077

 Score = 2156 bits (5587), Expect = 0.0
 Identities = 1077/1077 (100%), Positives = 1077/1077 (100%)

Query: 1    MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPS 60
            MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPS
Sbjct: 1    MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPS 60

Query: 61   FLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQV 120
            FLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQV
Sbjct: 61   FLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQV 120

Query: 121  SYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL 180
            SYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL
Sbjct: 121  SYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL 180

Query: 181  FLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK 240
            FLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
Sbjct: 181  FLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK 240

Query: 241  AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE 300
            AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
Sbjct: 241  AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE 300

Query: 301  LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG 360
            LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
Sbjct: 301  LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG 360

Query: 361  VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG 420
            VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG
Sbjct: 361  VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG 420

Query: 421  AYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTR 480
            AYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTR
Sbjct: 421  AYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTR 480

Query: 481  YLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAK 540
            YLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAK
Sbjct: 481  YLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAK 540

Query: 541  FFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFI 600
            FFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFI
Sbjct: 541  FFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFI 600

Query: 601  IQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRP 660
            IQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRP
Sbjct: 601  IQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRP 660

Query: 661  GLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPY 720
            GLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPY
Sbjct: 661  GLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPY 720

Query: 721  SMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDS 780
            SMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDS
Sbjct: 721  SMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDS 780

Query: 781  RPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRL 840
            RPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRL
Sbjct: 781  RPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRL 840

Query: 841  LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLR 900
            LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLR
Sbjct: 841  LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLR 900

Query: 901  LLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMV 960
            LLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMV
Sbjct: 901  LLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMV 960

Query: 961  EFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST 1020
            EFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST
Sbjct: 961  EFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST 1020

Query: 1021 GVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG 1077
            GVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG
Sbjct: 1021 GVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG 1077


>gi|115387102 adenylate cyclase 2 [Homo sapiens]
          Length = 1091

 Score = 1187 bits (3071), Expect = 0.0
 Identities = 605/1070 (56%), Positives = 772/1070 (72%), Gaps = 23/1070 (2%)

Query: 10   PPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCAL 69
            P S D  YE+YY +SQQ+PL++ LL IV+ +  ALLAV +A G E+    +FL TV  AL
Sbjct: 27   PRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTAL 86

Query: 70   GGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFT 129
              F  +  L   E   ++  R  S ++W+ L+A+G+ F+  GG VS WDQVS+FLF+IF 
Sbjct: 87   AIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFV 146

Query: 130  AYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGV 189
             Y MLP  MRDA +A + +S SH +VL + L   P  +  L+ Q+ AN ++F+CGN+AG 
Sbjct: 147  VYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGA 206

Query: 190  YHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQA 249
            YHK LME AL+ T+++  + + SR +L+ EK+ QE LLLS+LPA++A EMKAEI+ RLQ 
Sbjct: 207  YHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQG 266

Query: 250  GQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIA 309
             +  + E+TNNFH+LYVKRH  VS+LYADIVGFTRLAS+CSP ELV MLNELFGKFDQIA
Sbjct: 267  PKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIA 326

Query: 310  KEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGV 369
            KE+ECMRIKILGDCYYCVSGLP+SLP+HA NCV+MGLDMC AI+K+R ATGVDINMRVGV
Sbjct: 327  KENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGV 386

Query: 370  HSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGM 429
            HSG+VLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHI+  TL  L GAY VE+   
Sbjct: 387  HSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDG 446

Query: 430  EHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAK 489
            + RDPYL++    TY VI+P+ E    +        +L+G KMR S+ MTRYLESWGAAK
Sbjct: 447  DIRDPYLKQHLVKTYFVINPKGERRSPQHLFRP-RHTLDGAKMRASVRMTRYLESWGAAK 505

Query: 490  PFAHLSHGDSPV-------STSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFF 542
            PFAHL H DS         +T  P+ +    + + +    + R     ++EL   + +  
Sbjct: 506  PFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKR----FEEEL---NERMI 558

Query: 543  QVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQ 602
            Q I+ +N+QKQW +S+D   ++L F  K +EKEYR +A+PAFKYY  C  L+F   FI+Q
Sbjct: 559  QAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQ 618

Query: 603  MLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGL 662
            +LV  +   L I++   FLL   ILFVCF+  L++C  K   +L WL   SG++A RP  
Sbjct: 619  ILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWP 678

Query: 663  RIALGTATILLVFAMAITSLFFFPTSSDC---PFQAPNVSSMISNLSWELPGSLPLISVP 719
            RI+L   T  ++  MA+ ++FF   S +         N S   SN    +  +  L  +P
Sbjct: 679  RISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLP 738

Query: 720  YSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLD 779
            Y ++ C LG +SCS+FL +++ELK+L++++ L    ++ LH+HA      ++  Y   L 
Sbjct: 739  YFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAH-----VLGDYSQVLF 793

Query: 780  SRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTR 839
             RPG+ K+ K MG++S  IFF TLLVL RQNEYYCRLDFLWK K ++EREE ETMENL R
Sbjct: 794  ERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNR 853

Query: 840  LLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECL 899
            +LLENVLPAHVA  F+ ++ +NE+LYHQSY+CVCV+FAS+PDFKEFY+ES++N EGLECL
Sbjct: 854  VLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECL 913

Query: 900  RLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTM 959
            RLLNEIIADFD+LLSKPKFSGVEKIKTIGSTYMAATGL+A   Q+  Q+ ER   H+GTM
Sbjct: 914  RLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTM 973

Query: 960  VEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMES 1019
            VEFA AL  KLD INKHSFN+F+LRVG+NHGPV+AGVIGAQKPQYDIWGNTVNVASRM+S
Sbjct: 974  VEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDS 1033

Query: 1020 TGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRT 1069
            TGVL KIQVTEET+  LQ+LGYTC  RG+I VKGKG L TYF+NT+++R+
Sbjct: 1034 TGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRS 1083


>gi|4557255 adenylate cyclase 7 [Homo sapiens]
          Length = 1080

 Score = 1016 bits (2626), Expect = 0.0
 Identities = 572/1083 (52%), Positives = 713/1083 (65%), Gaps = 50/1083 (4%)

Query: 11   PSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPS----FLTTVL 66
            P +D  YE Y   SQ  PLLL LL +   A  AL+ +A++ G     DPS     L    
Sbjct: 16   PDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQG-----DPSRHQAILGMAF 70

Query: 67   CALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSA--WDQVSYFL 124
              L  F+ L  L   E  L+RW R L+ L W  L+ALG+  +F     +A  W+QV +FL
Sbjct: 71   LVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQVPFFL 130

Query: 125  FVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLG--PQPDSRPALLPQLAANAVLFL 182
            F++F  Y +LP  MR A   G  S+ SHLLVLG  +G    P  R  L  QL ANAV+FL
Sbjct: 131  FIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGL--QLLANAVIFL 188

Query: 183  CGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAE 242
            CGN+ G +HK  M+ A R  F   +  +  RR+L  EK+ QE+LLLS+LPA+++  MK  
Sbjct: 189  CGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLA 248

Query: 243  IMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELF 302
            I+ RL+     R    NNFHSLYVKRHQ VS+LYADIVGFT+LAS+CSPKELV++LNELF
Sbjct: 249  IIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELF 308

Query: 303  GKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVD 362
            GKFDQIAK +ECMRIKILGDCYYCVSGLP+SLP HA NCV+MGLDMC+AI+++R ATGVD
Sbjct: 309  GKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVD 368

Query: 363  INMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAY 422
            INMRVG+HSG+VLCGVIGL+KWQYDVWSHDV+LAN MEA GVPGRVHIT ATL  L  AY
Sbjct: 369  INMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAY 428

Query: 423  AVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYL 482
             VED   + RDPYL+E+   TYLVIDPR+++                LKMR S+ MTRYL
Sbjct: 429  EVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYL 488

Query: 483  ESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQ---WSLDRSRTPRGLDDELDTGDA 539
            ESWGAA+PFAHL+H +S  S  T +P         Q    + DRS +P+G  ++ D+ D 
Sbjct: 489  ESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSED-DSYDD 547

Query: 540  KFFQVIEQLNSQKQ-WKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSN 598
            +    IE L+S +    +S DF      F EK  E+EYRL+ IP  ++  AC  L+F+  
Sbjct: 548  EMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCI 607

Query: 599  FIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCV-LKGPKMLHWLPALSGLVA 657
             ++ +L+  R  AL +++ +   +  L+L +CF+    RC   +G      L  +S  V 
Sbjct: 608  LLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGT-----LCTISERVE 662

Query: 658  TRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLIS 717
            T+P LR+ L   TI  +  +AI +L         PFQ P +   + N +  L  S    +
Sbjct: 663  TQPLLRLTLAVLTIGSLLTVAIINLPLM------PFQVPELP--VGNETGLLAASSKTRA 714

Query: 718  ----VPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRL 773
                +PY    C LGF++CS+FL MS E K++LL + L A   LF  S  W  +C     
Sbjct: 715  LCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDC--CGQ 772

Query: 774  YLGPLDSRPGVL--------KEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLR 825
             LG L    G          K+ K M      +F+ TLL L+RQ +YYCRLD LWKKK +
Sbjct: 773  GLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCRLDCLWKKKFK 832

Query: 826  QEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEF 885
            +E EE ETMEN+ RLLLENVLPAHVA  FIG ++ NED YHQSY+CVCV+FASVPDFK F
Sbjct: 833  KEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKLNEDWYHQSYDCVCVMFASVPDFKVF 891

Query: 886  YSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDA 945
            Y+E ++N EGLECLRLLNEIIADFDELL KPKFSGVEKIKTIGSTYMAA GL+  SG + 
Sbjct: 892  YTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHE- 950

Query: 946  QQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYD 1005
             Q+ ER  +H+G MVEF++AL SKLD IN+HSFN+FRLRVG+NHGPV+AGVIGA+KPQYD
Sbjct: 951  NQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYD 1010

Query: 1006 IWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTD 1065
            IWGNTVNVASRMESTG LGKIQVTEET   LQ LGY+C  RG+I VKGKG+L TYF+ TD
Sbjct: 1011 IWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCTD 1070

Query: 1066 LTR 1068
              +
Sbjct: 1071 TAK 1073


>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
          Length = 1168

 Score =  649 bits (1675), Expect = 0.0
 Identities = 428/1093 (39%), Positives = 597/1093 (54%), Gaps = 115/1093 (10%)

Query: 17   YETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLL 76
            Y+ Y+    Q  L LL+  +VL   A LLA   A  R     P+++  + CA   F  L+
Sbjct: 140  YQRYFFQMNQSSLTLLMAVLVLLT-AVLLAFHAAPARP---QPAYVALLACAAALFVGLM 195

Query: 77   GLASREQRLQ--RWTRPLSGLVWVALLALGHAFLFTGGVVSA--WDQVSYFLFVIFTAYA 132
             + +R    Q   W      L  +A + +G A        SA  W  V    F ++ AY 
Sbjct: 196  VVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPV----FFVYIAYT 251

Query: 133  MLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALL-PQLAANAVLFLCGNVAGVYH 191
            +LP+ MR A ++GL  S  HL+     L  Q +   A L  QL AN +LFLC NV G+  
Sbjct: 252  LLPIRMRAAVLSGLGLSTLHLI-----LAWQLNRGDAFLWKQLGANVLLFLCTNVIGICT 306

Query: 192  KALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQ 251
                E + R  F+E    + +R  L  E + QE LLLS+LP ++A EMK +I  +     
Sbjct: 307  HYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK----- 361

Query: 252  GSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKE 311
                +    FH +Y+++H  VS+L+ADI GFT LAS+C+ +ELV+ LNELF +FD++A E
Sbjct: 362  ----KEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE 417

Query: 312  HECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHS 371
            + C+RIKILGDCYYCVSGLP +  DHA  CV MG+DM  AI  +R  TGV++NMRVG+HS
Sbjct: 418  NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHS 477

Query: 372  GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEH 431
            G V CGV+GL+KWQ+DVWS+DVTLANHMEAGG  GR+HIT ATL  L G Y VE      
Sbjct: 478  GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGE 537

Query: 432  RDPYLRELGEPTYLVIDPRAEEEDEKGTAGGL----LSSLEGLKMRPSLLMTRYLESWGA 487
            R+ YL+E    T+L++    + ++EK     L     +S+EGL  R           W  
Sbjct: 538  RNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPR-----------WVP 586

Query: 488  AKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQ 547
             + F+                 K   +F      D S+  RG  D L+  D     +   
Sbjct: 587  DRAFSR---------------TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRA 631

Query: 548  LNSQKQWKQSKD-FNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVT 606
            ++++   +  KD      L F+ +++EK+Y     P F  Y AC  LVF     IQ+L+ 
Sbjct: 632  IDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIF 691

Query: 607  NRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIAL 666
                 +   Y+  FLL L+ + +C    +  C    PK L     LS  +        A+
Sbjct: 692  PHSTLMLGIYASIFLLLLITVLIC---AVYSCGSLFPKALQ---RLSRSIVRSRAHSTAV 745

Query: 667  GTATILLVFAMAITSLFFFPTSSDCPFQ---------------APNVSSMISNLSWELP- 710
            G  ++LLVF  AI ++F   T +  P +               A ++  +  +L  + P 
Sbjct: 746  GIFSVLLVFTSAIANMF---TCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPL 802

Query: 711  --GSLPLISVP-YSMHCCTLGFLSCSLFLHMS--------FELKLL-LLLLWLAASCSLF 758
              G++P  S P Y +    L  L+ S+FLH+S        F L L+ L+LL L    ++F
Sbjct: 803  CEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIF 862

Query: 759  --------LHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQN 810
                    +H  A  +E          LD         K M  +   +F   L + A+Q 
Sbjct: 863  DNYDLLLGVHGLASSNET------FDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQV 916

Query: 811  EYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYE 870
            E   RLDFLWK +   E+EE E ++   R LL N+LP  VA  F+ + RRN++LY+QS E
Sbjct: 917  ESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCE 976

Query: 871  CVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGST 930
            CV V+FAS+ +F EFY E   N+EG+ECLRLLNEIIADFDE++S+ +F  +EKIKTIGST
Sbjct: 977  CVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGST 1036

Query: 931  YMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHG 990
            YMAA+GLNA++     +      SH+  + ++A+ L  ++  IN+HSFNNF++++GLN G
Sbjct: 1037 YMAASGLNASTYDQVGR------SHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMG 1090

Query: 991  PVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIK 1050
            PVVAGVIGA+KPQYDIWGNTVNV+SRM+STGV  +IQVT +    L + GY    RGV+K
Sbjct: 1091 PVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVK 1150

Query: 1051 VKGKGQLCTYFLN 1063
            VKGKG++ TYFLN
Sbjct: 1151 VKGKGEMTTYFLN 1163


>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
          Length = 1115

 Score =  643 bits (1659), Expect = 0.0
 Identities = 417/1061 (39%), Positives = 581/1061 (54%), Gaps = 104/1061 (9%)

Query: 17   YETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLL 76
            Y+ Y+    Q  L LL+  +VL   A LLA   A  R     P+++  + CA   F  L+
Sbjct: 140  YQRYFFQMNQSSLTLLMAVLVLLT-AVLLAFHAAPARP---QPAYVALLACAAALFVGLM 195

Query: 77   GLASREQRLQ--RWTRPLSGLVWVALLALGHAFLFTGGVVSA--WDQVSYFLFVIFTAYA 132
             + +R    Q   W      L  +A + +G A        SA  W  V    F ++ AY 
Sbjct: 196  VVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPV----FFVYIAYT 251

Query: 133  MLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALL-PQLAANAVLFLCGNVAGVYH 191
            +LP+ MR A ++GL  S  HL+     L  Q +   A L  QL AN +LFLC NV G+  
Sbjct: 252  LLPIRMRAAVLSGLGLSTLHLI-----LAWQLNRGDAFLWKQLGANVLLFLCTNVIGICT 306

Query: 192  KALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQ 251
                E + R  F+E    + +R  L  E + QE LLLS+LP ++A EMK +I  +     
Sbjct: 307  HYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK----- 361

Query: 252  GSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKE 311
                +    FH +Y+++H  VS+L+ADI GFT LAS+C+ +ELV+ LNELF +FD++A E
Sbjct: 362  ----KEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE 417

Query: 312  HECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHS 371
            + C+RIKILGDCYYCVSGLP +  DHA  CV MG+DM  AI  +R  TGV++NMRVG+HS
Sbjct: 418  NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHS 477

Query: 372  GSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEH 431
            G V CGV+GL+KWQ+DVWS+DVTLANHMEAGG  GR+HIT ATL  L G Y VE      
Sbjct: 478  GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGE 537

Query: 432  RDPYLRELGEPTYLVIDPRAEEEDEKGTAGGL----LSSLEGLKMRPSLLMTRYLESWGA 487
            R+ YL+E    T+L++    + ++EK     L     +S+EGL  R           W  
Sbjct: 538  RNAYLKEQHIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPR-----------WVP 586

Query: 488  AKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQ 547
             + F+                 K   +F      D S+  RG  D L+  D     +   
Sbjct: 587  DRAFSR---------------TKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRA 631

Query: 548  LNSQKQWKQSKD-FNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVT 606
            ++++   +  KD      L F+ +++EK+Y     P F  Y AC  LVF     IQ+L+ 
Sbjct: 632  IDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIF 691

Query: 607  NRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIAL 666
                 +   Y+  FLL L+ + +C    +  C    PK L     LS  +        A+
Sbjct: 692  PHSTLMLGIYASIFLLLLITVLIC---AVYSCGSLFPKALQ---RLSRSIVRSRAHSTAV 745

Query: 667  GTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSMHCCT 726
            G  ++LLVF  AI +++F             + +M+          L L++    +H  +
Sbjct: 746  GIFSVLLVFTSAIANMYF-------------IGNML----------LSLLASSVFLHISS 782

Query: 727  LGFLSCSLFLHMSFELKLLLLLLWLAASC----SLFLHSHAWLSECLIVRLYLGPLDSRP 782
            +G L+    L + +   L+LLLL   A+      L L  H   S           LD   
Sbjct: 783  IGKLAMIFVLGLIY---LVLLLLGPPATIFDNYDLLLGVHGLASS----NETFDGLDCPA 835

Query: 783  GVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLL 842
                  K M  +   +F   L + A+Q E   RLDFLWK +   E+EE E ++   R LL
Sbjct: 836  AGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLL 895

Query: 843  ENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLL 902
             N+LP  VA  F+ + RRN++LY+QS ECV V+FAS+ +F EFY E   N+EG+ECLRLL
Sbjct: 896  HNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLL 955

Query: 903  NEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEF 962
            NEIIADFDE++S+ +F  +EKIKTIGSTYMAA+GLNA++     +      SH+  + ++
Sbjct: 956  NEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR------SHITALADY 1009

Query: 963  AVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGV 1022
            A+ L  ++  IN+HSFNNF++++GLN GPVVAGVIGA+KPQYDIWGNTVNV+SRM+STGV
Sbjct: 1010 AMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGV 1069

Query: 1023 LGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLN 1063
              +IQVT +    L + GY    RGV+KVKGKG++ TYFLN
Sbjct: 1070 PDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1110


>gi|34486092 adenylate cyclase 5 [Homo sapiens]
          Length = 1261

 Score =  634 bits (1635), Expect = 0.0
 Identities = 423/1109 (38%), Positives = 609/1109 (54%), Gaps = 98/1109 (8%)

Query: 1    MARLFSPRPPPSEDL--FYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSD 58
            + ++F  +  PS+ L   Y+ Y+    Q  L +L+  +VL  L  L   A+ + R     
Sbjct: 212  LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVML---AFHAARPPLQL 268

Query: 59   PSFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVV---- 114
            P +L  +  A+G   ++  L +R      + +   GL   AL+A+  A    G ++    
Sbjct: 269  P-YLAVLAAAVGVILIMAVLCNRAA----FHQDHMGLACYALIAVVLAVQVVGLLLPQPR 323

Query: 115  SAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQL 174
            SA + + + +F I+T Y +LP+ MR A ++G+  S  HL +  L    Q      LL QL
Sbjct: 324  SASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAI-ALRTNAQDQF---LLKQL 379

Query: 175  AANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAY 234
             +N ++F C N+ GV      E + R  F+E    + +R     E + QE LLLS+LP +
Sbjct: 380  VSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRH 439

Query: 235  LAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKEL 294
            +A EMKA+I A+         +    FH +Y+++H  VS+L+ADI GFT LAS+C+ +EL
Sbjct: 440  VAMEMKADINAK---------QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL 490

Query: 295  VLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRK 354
            V+ LNELF +FD++A E+ C+RIKILGDCYYCVSGLP +  DHA  CV MG+DM  AI  
Sbjct: 491  VMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISL 550

Query: 355  LRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGAT 414
            +R  TGV++NMRVG+HSG V CGV+GL+KWQ+DVWS+DVTLANHMEAGG  GR+HIT AT
Sbjct: 551  VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKAT 610

Query: 415  LALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRP 474
            L  L G Y VE      R+ YL+E    T+L++    + ++EK       + +  +  + 
Sbjct: 611  LNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEK-------AMIAKMNRQR 663

Query: 475  SLLMTRYLESWGAAKPFA-HLSHGDSPVSTSTPLPEKTLASFSTQWSLDRS-RTPRGLDD 532
            +  +      WGA +PF  HL  G + VS       K +     +   D++ +     +D
Sbjct: 664  TNSIGHNPPHWGAERPFYNHL--GGNQVS-------KEMKRMGFEDPKDKNAQESANPED 714

Query: 533  ELDT--GDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEAC 590
            E+D   G A   + I++L S+   K         L FRE ++EK+Y       F  Y AC
Sbjct: 715  EVDEFLGRAIDARSIDRLRSEHVRK-------FLLTFREPDLEKKYSKQVDDRFGAYVAC 767

Query: 591  TFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLP 650
              LVFL    +Q+ +      +   Y    LL  L++FV     +  CV   P  L    
Sbjct: 768  ASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSV---IYSCVKLFPSPLQ--- 821

Query: 651  ALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSS--DCPFQAPNVSSMISN---- 704
             LS  +         +G  TI LVF  A  ++F   +     C  Q  N+S+   N    
Sbjct: 822  TLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHV 881

Query: 705  ----LSWELPGSLPLISVP--------YSMHCCTLGFLSCSLFLHMS--------FELKL 744
                +++ L         P        Y  +   L  L+CS+FL +S          ++L
Sbjct: 882  AESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIEL 941

Query: 745  LLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSRPGVLKEP-KLMGAISFFIFFFTL 803
            + +L+      +LF ++   ++   I     G         K   K++  I   +F   L
Sbjct: 942  IYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLAL 1001

Query: 804  LVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNED 863
             + A+Q E   RLDFLWK +  +E+EE E ++   R LL N+LP  VA  F+ + RRN++
Sbjct: 1002 YLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDE 1061

Query: 864  LYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEK 923
            LY+QS ECV V+FAS+ +F EFY E   N+EG+ECLRLLNEIIADFDE++S+ +F  +EK
Sbjct: 1062 LYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEK 1121

Query: 924  IKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRL 983
            IKTIGSTYMAA+GLN     D+  D +   +H+  + +FA+ L  ++  IN+HSFNNF++
Sbjct: 1122 IKTIGSTYMAASGLN-----DSTYD-KVGKTHIKALADFAMKLMDQMKYINEHSFNNFQM 1175

Query: 984  RVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTC 1043
            ++GLN GPVVAGVIGA+KPQYDIWGNTVNVASRM+STGV  +IQVT +    L +  Y  
Sbjct: 1176 KIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQL 1235

Query: 1044 YSRGVIKVKGKGQLCTYFLNTDLTRTGPP 1072
              RGV+KVKGKG++ TYFLN      GPP
Sbjct: 1236 ECRGVVKVKGKGEMMTYFLN-----GGPP 1259


>gi|4557257 adenylate cyclase 8 [Homo sapiens]
          Length = 1251

 Score =  595 bits (1535), Expect = e-170
 Identities = 374/984 (38%), Positives = 552/984 (56%), Gaps = 72/984 (7%)

Query: 93   SGLV-WVAL----LALGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLA 147
            SG+V WVA+    LA G  +   G      D + Y LF +F  Y+MLPL +  A +AGL 
Sbjct: 245  SGVVTWVAMTTQILAAGLGYGLLG------DGIGYVLFTLFATYSMLPLPLTWAILAGLG 298

Query: 148  SSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREAL 207
            +SL  +++  +     P      + Q+ A AVLF+C N AG++   L +RA R  F E  
Sbjct: 299  TSLLQVILQVVI----PRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETR 354

Query: 208  SSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVK 267
              + +R RL+TE + QE L+LS+LP ++  EM  ++               + FH +Y+ 
Sbjct: 355  RCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMT------NVEDEHLQHQFHRIYIH 408

Query: 268  RHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCV 327
            R++ VS+L+AD+ GFT L++  S +ELV MLNELF +FD++A EH C+RIKILGDCYYCV
Sbjct: 409  RYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCV 468

Query: 328  SGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYD 387
            SGLP    DHA  CV MGL M + IR +R+ T  D++MR+G+HSGSVLCGV+GL+KWQ+D
Sbjct: 469  SGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFD 528

Query: 388  VWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHRDPYLRELGEPTYLVI 447
            VWS DV +AN +E+GG+PGR+HI+ ATL  L G Y VE+   + R+ +LR+    TYL+ 
Sbjct: 529  VWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIK 588

Query: 448  DPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPL 507
             P   E+        ++        R +   T    SW    PF ++    + ++  T  
Sbjct: 589  QP---EDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRN 645

Query: 508  PEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYF 567
                L +   Q +L     P  ++  ++         I+  +  K  ++     P +L F
Sbjct: 646  SINLLPNHLAQ-ALHVQSGPEEINKRIE-------HTIDLRSGDKLRREH--IKPFSLMF 695

Query: 568  REKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLV-TNRPPALAITYSITFLLFLLI 626
            ++  +E +Y       FK    C F+V L    IQ L+ ++R   + I +SI  +L   +
Sbjct: 696  KDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSAL 755

Query: 627  LFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFP 686
            + +  +ED     L   K   W+             R  +  A+IL+ F  AI ++ +  
Sbjct: 756  VLITTAEDYKCLPLILRKTCCWINETYLA-------RNVIIFASILINFLGAILNILW-- 806

Query: 687  TSSDCPFQAPNVSSMISNLSWELPGSLP-LISVP-YSMHCCTLGFLSCSLFLHMSFELKL 744
                C F     S  + NL++        + S P Y +    L  ++C++FL ++  LKL
Sbjct: 807  ----CDFDK---SIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKL 859

Query: 745  LLLLLWLAASCSLFLHSHAWLSECLIVRLYL--GPLDSRPGVLKEPKLMGAISFFIFFFT 802
             +LL+ +A         +A L+E +   L+L    L+         K +  +   +F   
Sbjct: 860  AVLLIMIAI--------YALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLA 911

Query: 803  LLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNE 862
            +    +Q EY  RLDFLW+ + ++E  E + +      +L N+LP+HVA  F+ ++R NE
Sbjct: 912  VFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNE 971

Query: 863  DLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVE 922
            +LY QSY+ V V+FAS+P F +FYS++ +N++G+ECLRLLNEIIADFDELL + +F  +E
Sbjct: 972  ELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIE 1031

Query: 923  KIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFR 982
            KIKTIGSTYMA +GL+       +Q  E    HL  + +F++AL   +  INKHSFNNF 
Sbjct: 1032 KIKTIGSTYMAVSGLS-----PEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFE 1086

Query: 983  LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYT 1042
            LR+G++HG VVAGVIGA+KPQYDIWG TVN+ASRM+STGV G+IQV EET   L+  G+ 
Sbjct: 1087 LRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFA 1146

Query: 1043 CYSRGVIKVKG----KGQLCTYFL 1062
               RG I VKG    +G++ TYFL
Sbjct: 1147 FDYRGEIYVKGISEQEGKIKTYFL 1170


>gi|31083193 adenylate cyclase 1 [Homo sapiens]
          Length = 1119

 Score =  594 bits (1531), Expect = e-169
 Identities = 392/980 (40%), Positives = 545/980 (55%), Gaps = 77/980 (7%)

Query: 111  GGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPAL 170
            GG  +A   V   L V F +YA+LP+    A   GL  + SHLLV    +   P  RP L
Sbjct: 154  GGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLV---PAKRPRL 210

Query: 171  LPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSI 230
               L ANA+LF+  N+ GV+ + L ER+ R  F +A S +  R RL+ E + QE LL+S+
Sbjct: 211  WRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSL 270

Query: 231  LPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECS 290
            LP  +A EMK + +          PE    FH +Y++RH  VS+L+ADIVGFT LAS+C+
Sbjct: 271  LPRNVAMEMKEDFL--------KPPERI--FHKIYIQRHDNVSILFADIVGFTGLASQCT 320

Query: 291  PKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCR 350
             +ELV +LNELFGKFD++A E+ C RIKILGDCYYCVSGL     DHA  CV MGLDM  
Sbjct: 321  AQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMID 380

Query: 351  AIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHI 410
             I  +  AT VD+NMRVG+H+G VLCGV+GL+KWQYDVWS+DVTLAN MEA G+PG+VHI
Sbjct: 381  TITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHI 440

Query: 411  TGATLALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGL 470
            T  TLA L G Y VE      R+ +L+     T+ ++         K   G +LS ++  
Sbjct: 441  TKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIV----PSHRRKIFPGLILSDIKPA 496

Query: 471  K-MRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRG 529
            K M+   +    ++     K F       + ++       + L + S +    R+R+   
Sbjct: 497  KRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKL---RNRSSFS 553

Query: 530  LDDELDTGDAKFFQVIEQLNSQKQWK-QSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYE 588
             +    T   +  + I +L   +Q + +  D N  TL ++  E E++Y       F    
Sbjct: 554  TNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAV 613

Query: 589  ACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHW 648
              T ++     ++ +L+   P ++ +       L LL+  +CF   L+ CVL     LH 
Sbjct: 614  VLTLILAALFGLVYLLIF--PQSVVV-------LLLLVFCICF---LVACVL----YLH- 656

Query: 649  LPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPF--------QAPNVSS 700
                   V   PG  + +   T+L +F + +     +  +  C            PN S 
Sbjct: 657  ----ITRVQCFPGC-LTIQIRTVLCIFIVVL----IYSVAQGCVVGCLPWAWSSKPNSSL 707

Query: 701  MISNLSWE---LPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSL 757
            ++ +   +   LP +LP  S  +++ CC +G L  ++F  +S  L  ++LL  L  S  L
Sbjct: 708  VVLSSGGQRTALP-TLPCESTHHALLCCLVGTLPLAIFFRVS-SLPKMILLSGLTTSYIL 765

Query: 758  FLHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLD 817
             L    +       R   G +  R     EP     ++  +F   L + ARQ +   RLD
Sbjct: 766  VLELSGY------TRTGGGAVSGRS---YEP----IVAILLFSCALALHARQVDIRLRLD 812

Query: 818  FLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFA 877
            +LW  +  +ERE+ E ++   R +L N+LPAHVA  F+  N RN DLY+QSY  V V+FA
Sbjct: 813  YLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFA 872

Query: 878  SVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGL 937
            S+P+F +FY E + N+ G+ECLRLLNEIIADFDEL+ K  +  +EKIKTIGSTYMAA GL
Sbjct: 873  SIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGL 932

Query: 938  NATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVI 997
              TSG  A++      SHL T+ +FA+ +   LD IN  S+N+F LRVG+N GPVVAGVI
Sbjct: 933  APTSGTKAKKSIS---SHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVI 989

Query: 998  GAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQL 1057
            GA++PQYDIWGNTVNVASRM+STGV G+IQVTEE    L+   Y    RG + VKGKG++
Sbjct: 990  GARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEM 1049

Query: 1058 CTYFLNTDLTRTGPPSATLG 1077
             TYFL       G    +LG
Sbjct: 1050 LTYFLEGRTDGNGSQIRSLG 1069


>gi|148536830 adenylate cyclase 3 [Homo sapiens]
          Length = 1144

 Score =  552 bits (1422), Expect = e-157
 Identities = 390/1119 (34%), Positives = 589/1119 (52%), Gaps = 93/1119 (8%)

Query: 10   PPSEDLFYETYYSLSQQYPLLLLLLGIVL--CALAALLAVAWASGRELTSDPSFLTTVLC 67
            P S +  Y+TY+   +   LL+L++   L  C +  + AV ++S +  +   + +  VL 
Sbjct: 59   PESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLD 118

Query: 68   ALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTG--GVVSAWDQVSYFLF 125
             +       GL     R+ R  R L  ++W+ + A   ++L        +A D V + +F
Sbjct: 119  IILFVLCKKGLLP--DRVTR--RVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVF 174

Query: 126  VIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSR---PALLPQLAANAVLFL 182
             +F+ +  LPL +    +  + S + H LVLG+ +  Q         LL ++ AN  L+L
Sbjct: 175  FVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYL 234

Query: 183  CGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAE 242
            C    G+    + +R  R  F EA  SL  +  L+ + + QE+L+LSILP ++A EM  +
Sbjct: 235  CAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKD 294

Query: 243  IMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELF 302
            +       +    +    F+++Y+ RH+ VS+L+ADIVGFT+L+S CS +ELV +LNELF
Sbjct: 295  MK------KDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELF 348

Query: 303  GKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVD 362
             +FD++A ++  +RIKILGDCYYC+ GLP    DHA+  + MGL M  AI  +R  T   
Sbjct: 349  ARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTG 408

Query: 363  INMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAY 422
            ++MRVGVH+G+VL GV+G ++WQYDVWS DVT+AN MEAGG+PGRVHI+ +T+  L G +
Sbjct: 409  VDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEF 468

Query: 423  AVEDAGMEHRDPYLRELGEPTYLVIDPRAEEED---EKGTAGGLLSS---LEGLKMRPSL 476
             VE      R  YL E G  TYL+I  + E +    + G  G  L +          P+L
Sbjct: 469  DVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPAL 528

Query: 477  LMTRYLESWGAA--------KPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPR 528
            + T+  E  G+A        KP    +  D+P   S P P + L            R   
Sbjct: 529  IETK--EPNGSAHSSGSTSEKPEEQDAQADNP---SFPNPRRRLRLQDLA-----DRVVD 578

Query: 529  GLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYE 588
              +DE +        ++E+ ++Q   K++     L++ F + EME  Y +          
Sbjct: 579  ASEDEHELNQLLNEALLERESAQVVKKRNTFL--LSMRFMDPEMETRYSVEKEKQSGAAF 636

Query: 589  ACTFLVFLSNFIIQMLVTNRPPALAITYSITFL---LFLLILFVCFSEDLMRCVLKGPKM 645
            +C+ +V L   ++++L+    P L   Y +TF+   + LLIL +C    +       PK 
Sbjct: 637  SCSCVVLLCTALVEILID---PWLMTNY-VTFMVGEILLLILTICSLAAIFPRAF--PKK 690

Query: 646  LHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNL 705
            L    A S  +      R A  T  +L +F + + ++    +         N ++     
Sbjct: 691  L---VAFSTWIDRT---RWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATA----- 739

Query: 706  SWELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHS---- 761
              E  GS  L +  Y  +   L  ++  + + +S  +KL L+LL   A  ++ L++    
Sbjct: 740  GMETEGSC-LENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPV 798

Query: 762  -----HAWLSECLIVRLYLGPLDS-RPGV-------LKEPKLMGAISFFIFFFTLLVLAR 808
                 H    E  +  + L  +    PG+       L   K    +  F+   +    +R
Sbjct: 799  FDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSR 858

Query: 809  QNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQS 868
              E   R  FLWK ++  ++E    M      L+ N+LP HVA  F+G  +R+E+LY Q+
Sbjct: 859  HVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQT 918

Query: 869  YECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIG 928
            Y+ + V+FAS+P+F +FY+E +IN+ G+ECLR LNEII+DFD LL  PKF  + KIKTIG
Sbjct: 919  YDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIG 978

Query: 929  STYMAATGLN--------ATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNN 980
            STYMAA+G+         A+S ++ + + ER   HL  + +FA+A+   L  IN  SFNN
Sbjct: 979  STYMAASGVTPDVNTNGFASSNKEDKSERER-WQHLADLADFALAMKDTLTNINNQSFNN 1037

Query: 981  FRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLG 1040
            F LR+G+N G V+AGVIGA+KP YDIWGNTVNVASRMESTGV+G IQV EET   L+  G
Sbjct: 1038 FMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYG 1097

Query: 1041 YTCYSRGVIKVKGKGQLCTYFL-NTDLTRTGP--PSATL 1076
            +    RG I VKGKG+L T+FL   D   T P  PS TL
Sbjct: 1098 FRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTL 1136


>gi|50959205 adenylate cyclase 9 [Homo sapiens]
          Length = 1353

 Score =  393 bits (1010), Expect = e-109
 Identities = 325/1005 (32%), Positives = 486/1005 (48%), Gaps = 153/1005 (15%)

Query: 169  ALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLL 228
            AL  +L +  +L  C +  GV+   + +   R+TF +   S+   + L+ EK  +E ++ 
Sbjct: 276  ALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIH 335

Query: 229  SILPAYLAREM------KAEIMARLQAGQGSRPESTNN--------FHSLYVKRHQGVSV 274
            S++P  +A ++      ++E   +  A    +     +        F    +++ + VS+
Sbjct: 336  SVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSI 395

Query: 275  LYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSL 334
            L+ADIVGFT++++  S   LV +LN+LFG+FD++ +E +C +I  LGDCYYCV+G P   
Sbjct: 396  LFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPR 455

Query: 335  PDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVT 394
             DHA  C+ MGL M +AI +        +NMRVGVH+G+VLCG++G++++++DVWS+DV 
Sbjct: 456  ADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVN 515

Query: 395  LANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHR---DPYLREL-GEPTYLVIDPR 450
            LAN ME  GV G+VHI+ AT   L   Y +ED  +  R        +L G  TYL+   R
Sbjct: 516  LANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERLGQSVVADQLKGLKTYLISGQR 575

Query: 451  AEEED------------------------EKGTAGG--------LLSSLEGLKMRPSLLM 478
            A+E                           +GTA           + + + LK  PS  +
Sbjct: 576  AKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGI 635

Query: 479  TRYLESWGAA-------------KPFAHLSHGDSPVSTS---TPLPEKTLASFST----- 517
            T   +S   A             K     S G +P + +   +P  E+ L +  T     
Sbjct: 636  TFAPKSEAGAEGGAPQNGCQDEHKNSTKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEI 695

Query: 518  -----QW---SLDRSRT-PRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFR 568
                 +W   SLD+S   P    +  +  DA F  VI++ +  K +      N  +L F 
Sbjct: 696  LQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFL 755

Query: 569  EKEMEKEYRLS------AIPAFKYYEACTFL----VFLSNFIIQMLVTN----------- 607
            ++E+E+ YR S           K + + TF     VFLS  +   L T            
Sbjct: 756  DQELERSYRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAATVP 815

Query: 608  RPPALAITYSITFLLFLLIL-----FVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGL 662
             PPA    +S   LL +L L      V F ED+M C     ++L W+   +G +      
Sbjct: 816  PPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACT---KRLLEWI---AGWLP----- 864

Query: 663  RIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSM 722
            R  +G   + L  A+A+ S       ++  F                 GS  LI+V +  
Sbjct: 865  RHCIGAILVSLP-ALAVYSHVTSEYETNIHFPV-------------FTGSAALIAVVHYC 910

Query: 723  HCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSR- 781
            + C L     S    +     LLLL + L    S+       +      R    P +S  
Sbjct: 911  NFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSER---NPCNSSV 967

Query: 782  PGVLKEP-KLMGAISFFIFFFTLLV---LARQNEYYCRLDFLWKKKLRQEREETETMENL 837
            P  L+ P  L+G     +FF  LL+   L R+ E   RL +    +    R + ++M + 
Sbjct: 968  PRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQ 1027

Query: 838  TRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEG-L 896
               LL N++P HVA Q      +    Y ++++   V+FAS+ +F EFY E   N+EG  
Sbjct: 1028 ADWLLRNIIPYHVAEQL-----KVSQTYSKNHDSGGVIFASIVNFSEFYEE---NYEGGK 1079

Query: 897  ECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHL 956
            EC R+LNE+I DFDELLSKP +S +EKIKTIG+TYMAA+GLN    QD     E    HL
Sbjct: 1080 ECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQE----HL 1135

Query: 957  GTMVEFAVALGSKLDVINKHS-FNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVAS 1015
              + EFA  +   +D  N +  + NF+LRVG NHGP+ AGVIG  K  YDIWG+TVN+AS
Sbjct: 1136 QILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIAS 1195

Query: 1016 RMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTY 1060
            RM++TGV  +IQV+EE+   L  +GY    RG + VKGKGQ+ TY
Sbjct: 1196 RMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240


>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
           sapiens]
          Length = 455

 Score =  122 bits (307), Expect = 1e-27
 Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 25/220 (11%)

Query: 199 LRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPEST 258
           L+AT  +A       + L+ EKK    LL SI P         E+  +L  GQ       
Sbjct: 197 LKATLEQA------HQALEEEKKKTVDLLCSIFPC--------EVAQQLWQGQ------- 235

Query: 259 NNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIK 318
                +  K+   V++L++DIVGFT + S+CSP +++ MLN L+ +FDQ   E +  +++
Sbjct: 236 ----VVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 291

Query: 319 ILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGV 378
            +GD Y    GL      HA+    M L M     ++ +  G  I MR+G+HSGSV  GV
Sbjct: 292 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGV 351

Query: 379 IGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALL 418
           +G++  +Y ++ ++VTLAN  E+  VP +++++  T  LL
Sbjct: 352 VGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 391



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 22/212 (10%)

Query: 821  KKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVP 880
            K  L Q  +  E  +  T  LL ++ P  VA Q      + + +  + +  V +LF+ + 
Sbjct: 198  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIV 253

Query: 881  DFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAT 940
             F    S+ +     L+ + +LN +   FD+   +     V K++TIG  Y  A GL+  
Sbjct: 254  GFTAICSQCS----PLQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKE 306

Query: 941  SGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
            S   A Q A  +      M+E +       +V++ H     ++R+GL+ G V AGV+G +
Sbjct: 307  SDTHAVQIALMALK----MMELSD------EVMSPHG-EPIKMRIGLHSGSVFAGVVGVK 355

Query: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
             P+Y ++GN V +A++ ES  V  KI V+  T
Sbjct: 356  MPRYCLFGNNVTLANKFESCSVPRKINVSPTT 387


>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  122 bits (307), Expect = 1e-27
 Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 25/220 (11%)

Query: 199 LRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPEST 258
           L+AT  +A       + L+ EKK    LL SI P         E+  +L  GQ       
Sbjct: 432 LKATLEQA------HQALEEEKKKTVDLLCSIFPC--------EVAQQLWQGQ------- 470

Query: 259 NNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIK 318
                +  K+   V++L++DIVGFT + S+CSP +++ MLN L+ +FDQ   E +  +++
Sbjct: 471 ----VVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 526

Query: 319 ILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGV 378
            +GD Y    GL      HA+    M L M     ++ +  G  I MR+G+HSGSV  GV
Sbjct: 527 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGV 586

Query: 379 IGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALL 418
           +G++  +Y ++ ++VTLAN  E+  VP +++++  T  LL
Sbjct: 587 VGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 22/212 (10%)

Query: 821  KKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVP 880
            K  L Q  +  E  +  T  LL ++ P  VA Q      + + +  + +  V +LF+ + 
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIV 488

Query: 881  DFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAT 940
             F    S+ +     L+ + +LN +   FD+   +     V K++TIG  Y  A GL+  
Sbjct: 489  GFTAICSQCS----PLQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKE 541

Query: 941  SGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
            S   A Q A  +      M+E +       +V++ H     ++R+GL+ G V AGV+G +
Sbjct: 542  SDTHAVQIALMALK----MMELSD------EVMSPHG-EPIKMRIGLHSGSVFAGVVGVK 590

Query: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
             P+Y ++GN V +A++ ES  V  KI V+  T
Sbjct: 591  MPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622


>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  122 bits (307), Expect = 1e-27
 Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 25/220 (11%)

Query: 199 LRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPEST 258
           L+AT  +A       + L+ EKK    LL SI P         E+  +L  GQ       
Sbjct: 432 LKATLEQA------HQALEEEKKKTVDLLCSIFPC--------EVAQQLWQGQ------- 470

Query: 259 NNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIK 318
                +  K+   V++L++DIVGFT + S+CSP +++ MLN L+ +FDQ   E +  +++
Sbjct: 471 ----VVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 526

Query: 319 ILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGV 378
            +GD Y    GL      HA+    M L M     ++ +  G  I MR+G+HSGSV  GV
Sbjct: 527 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGV 586

Query: 379 IGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALL 418
           +G++  +Y ++ ++VTLAN  E+  VP +++++  T  LL
Sbjct: 587 VGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 22/212 (10%)

Query: 821  KKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVP 880
            K  L Q  +  E  +  T  LL ++ P  VA Q      + + +  + +  V +LF+ + 
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIV 488

Query: 881  DFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAT 940
             F    S+ +     L+ + +LN +   FD+   +     V K++TIG  Y  A GL+  
Sbjct: 489  GFTAICSQCS----PLQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKE 541

Query: 941  SGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
            S   A Q A  +      M+E +       +V++ H     ++R+GL+ G V AGV+G +
Sbjct: 542  SDTHAVQIALMALK----MMELSD------EVMSPHG-EPIKMRIGLHSGSVFAGVVGVK 590

Query: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
             P+Y ++GN V +A++ ES  V  KI V+  T
Sbjct: 591  MPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622


>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  122 bits (307), Expect = 1e-27
 Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 25/220 (11%)

Query: 199 LRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPEST 258
           L+AT  +A       + L+ EKK    LL SI P         E+  +L  GQ       
Sbjct: 432 LKATLEQA------HQALEEEKKKTVDLLCSIFPC--------EVAQQLWQGQ------- 470

Query: 259 NNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIK 318
                +  K+   V++L++DIVGFT + S+CSP +++ MLN L+ +FDQ   E +  +++
Sbjct: 471 ----VVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 526

Query: 319 ILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGV 378
            +GD Y    GL      HA+    M L M     ++ +  G  I MR+G+HSGSV  GV
Sbjct: 527 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGV 586

Query: 379 IGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALL 418
           +G++  +Y ++ ++VTLAN  E+  VP +++++  T  LL
Sbjct: 587 VGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 22/212 (10%)

Query: 821  KKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVP 880
            K  L Q  +  E  +  T  LL ++ P  VA Q      + + +  + +  V +LF+ + 
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIV 488

Query: 881  DFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAT 940
             F    S+ +     L+ + +LN +   FD+   +     V K++TIG  Y  A GL+  
Sbjct: 489  GFTAICSQCS----PLQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKE 541

Query: 941  SGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
            S   A Q A  +      M+E +       +V++ H     ++R+GL+ G V AGV+G +
Sbjct: 542  SDTHAVQIALMALK----MMELSD------EVMSPHG-EPIKMRIGLHSGSVFAGVVGVK 590

Query: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
             P+Y ++GN V +A++ ES  V  KI V+  T
Sbjct: 591  MPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622


>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
           sapiens]
          Length = 690

 Score =  122 bits (307), Expect = 1e-27
 Identities = 73/220 (33%), Positives = 117/220 (53%), Gaps = 25/220 (11%)

Query: 199 LRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPEST 258
           L+AT  +A       + L+ EKK    LL SI P         E+  +L  GQ       
Sbjct: 432 LKATLEQA------HQALEEEKKKTVDLLCSIFPC--------EVAQQLWQGQ------- 470

Query: 259 NNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIK 318
                +  K+   V++L++DIVGFT + S+CSP +++ MLN L+ +FDQ   E +  +++
Sbjct: 471 ----VVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 526

Query: 319 ILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGV 378
            +GD Y    GL      HA+    M L M     ++ +  G  I MR+G+HSGSV  GV
Sbjct: 527 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGV 586

Query: 379 IGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALL 418
           +G++  +Y ++ ++VTLAN  E+  VP +++++  T  LL
Sbjct: 587 VGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 22/212 (10%)

Query: 821  KKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVP 880
            K  L Q  +  E  +  T  LL ++ P  VA Q      + + +  + +  V +LF+ + 
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIV 488

Query: 881  DFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAT 940
             F    S+ +     L+ + +LN +   FD+   +     V K++TIG  Y  A GL+  
Sbjct: 489  GFTAICSQCS----PLQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKE 541

Query: 941  SGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
            S   A Q A  +      M+E +       +V++ H     ++R+GL+ G V AGV+G +
Sbjct: 542  SDTHAVQIALMALK----MMELSD------EVMSPHG-EPIKMRIGLHSGSVFAGVVGVK 590

Query: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
             P+Y ++GN V +A++ ES  V  KI V+  T
Sbjct: 591  MPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622


>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
          Length = 1047

 Score =  120 bits (301), Expect = 7e-27
 Identities = 88/271 (32%), Positives = 139/271 (51%), Gaps = 30/271 (11%)

Query: 805  VLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDL 864
            +L R  +Y   L+ L +++ +   EE    E     LL  +LP  VA Q     +R E +
Sbjct: 801  LLLRMEQYANNLEKLVEERTQAYLEEKRKAE----ALLYQILPHSVAEQL----KRGETV 852

Query: 865  YHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKI 924
              ++++ V + F+ +  F    +ES      ++ + LLN++   FD ++       V K+
Sbjct: 853  QAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAIIDN---FDVYKV 905

Query: 925  KTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDV--INKHSFNNFR 982
            +TIG  YM  +GL   +GQ           H   +   A+AL   +    I     +  R
Sbjct: 906  ETIGDAYMVVSGLPGRNGQ----------RHAPEIARMALALLDAVSSFRIRHRPHDQLR 955

Query: 983  LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLG-Y 1041
            LR+G++ GPV AGV+G + P+Y ++G+TVN ASRMES G   KI V+  T  AL  LG +
Sbjct: 956  LRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCF 1015

Query: 1042 TCYSRGVIKVKGKGQLCTYFLNTDLTRTGPP 1072
                RG +++KGKG++ TY+L  +  R GPP
Sbjct: 1016 QLELRGDVEMKGKGKMRTYWLLGE--RKGPP 1044



 Score =  102 bits (254), Expect = 2e-21
 Identities = 62/203 (30%), Positives = 108/203 (53%), Gaps = 4/203 (1%)

Query: 215  RLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSV 274
            R++    + E L+     AYL  + KAE +   Q    S  E      ++  +    V++
Sbjct: 804  RMEQYANNLEKLVEERTQAYLEEKRKAEALL-YQILPHSVAEQLKRGETVQAEAFDSVTI 862

Query: 275  LYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLP-LS 333
             ++DIVGFT L++E +P ++V +LN+L+  FD I    +  +++ +GD Y  VSGLP  +
Sbjct: 863  YFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRN 922

Query: 334  LPDHAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSH 391
               HA    RM L +  A+   ++R      + +R+GVH+G V  GV+GL+  +Y ++  
Sbjct: 923  GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGD 982

Query: 392  DVTLANHMEAGGVPGRVHITGAT 414
             V  A+ ME+ G   ++H++  T
Sbjct: 983  TVNTASRMESNGQALKIHVSSTT 1005


>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
           sapiens]
          Length = 624

 Score =  120 bits (301), Expect = 7e-27
 Identities = 71/216 (32%), Positives = 115/216 (53%), Gaps = 25/216 (11%)

Query: 199 LRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPEST 258
           L+AT  +A       + L+ EKK    LL SI P         E+  +L  GQ       
Sbjct: 432 LKATLEQA------HQALEEEKKKTVDLLCSIFPC--------EVAQQLWQGQ------- 470

Query: 259 NNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIK 318
                +  K+   V++L++DIVGFT + S+CSP +++ MLN L+ +FDQ   E +  +++
Sbjct: 471 ----VVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVE 526

Query: 319 ILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGV 378
            +GD Y    GL      HA+    M L M     ++ +  G  I MR+G+HSGSV  GV
Sbjct: 527 TIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGV 586

Query: 379 IGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGAT 414
           +G++  +Y ++ ++VTLAN  E+  VP +++++  T
Sbjct: 587 VGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 60/212 (28%), Positives = 102/212 (48%), Gaps = 22/212 (10%)

Query: 821  KKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVP 880
            K  L Q  +  E  +  T  LL ++ P  VA Q      + + +  + +  V +LF+ + 
Sbjct: 433  KATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLFSDIV 488

Query: 881  DFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNAT 940
             F    S+ +     L+ + +LN +   FD+   +     V K++TIG  Y  A GL+  
Sbjct: 489  GFTAICSQCS----PLQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKE 541

Query: 941  SGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
            S   A Q A  +      M+E +       +V++ H     ++R+GL+ G V AGV+G +
Sbjct: 542  SDTHAVQIALMALK----MMELSD------EVMSPHG-EPIKMRIGLHSGSVFAGVVGVK 590

Query: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
             P+Y ++GN V +A++ ES  V  KI V+  T
Sbjct: 591  MPRYCLFGNNVTLANKFESCSVPRKINVSPTT 622


>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
          Length = 1061

 Score =  114 bits (285), Expect = 5e-25
 Identities = 82/264 (31%), Positives = 136/264 (51%), Gaps = 34/264 (12%)

Query: 805  VLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDL 864
            +L+R  +Y   L+ L +++ +   EE    E     LL  +LP  VA Q     +R E +
Sbjct: 816  LLSRMEQYANNLEELVEERTQAYLEEKRKAE----ALLYQILPHSVAEQL----KRGETV 867

Query: 865  YHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKI 924
              ++++ V + F+ +  F    +ES      ++ + LLN++   FD ++       V K+
Sbjct: 868  QAEAFDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAVIDN---FDVYKV 920

Query: 925  KTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNN---- 980
            +TIG  YM  +GL   +G+           H   +   A+AL   LD +      +    
Sbjct: 921  ETIGDAYMVVSGLPVRNGR----------LHACEVARMALAL---LDAVRSFRIRHRPQE 967

Query: 981  -FRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL 1039
              RLR+G++ GPV AGV+G + P+Y ++G+TVN ASRMES G   KI ++ ET   L+  
Sbjct: 968  QLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEF 1027

Query: 1040 -GYTCYSRGVIKVKGKGQLCTYFL 1062
             G+    RG +++KGKG++ TY+L
Sbjct: 1028 GGFELELRGDVEMKGKGKVRTYWL 1051



 Score =  109 bits (272), Expect = 2e-23
 Identities = 82/287 (28%), Positives = 137/287 (47%), Gaps = 30/287 (10%)

Query: 151  SHLLVLGLYL----GPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREA 206
            SHL  LGL +       P  RP    Q+      F   N + +    L      A   E 
Sbjct: 771  SHLEELGLLMQRCWAEDPQERPPF-QQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEE 829

Query: 207  LSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYV 266
            L    ++  L+ EK+  E LL  ILP  +A ++K     + +A                 
Sbjct: 830  LVEERTQAYLE-EKRKAEALLYQILPHSVAEQLKRGETVQAEA----------------- 871

Query: 267  KRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYC 326
                 V++ ++DIVGFT L++E +P ++V +LN+L+  FD +    +  +++ +GD Y  
Sbjct: 872  --FDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMV 929

Query: 327  VSGLPLSLPD-HAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQK 383
            VSGLP+     HA    RM L +  A+R  ++R      + +R+G+H+G V  GV+GL+ 
Sbjct: 930  VSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKM 989

Query: 384  WQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLA--GAYAVEDAG 428
             +Y ++   V  A+ ME+ G   ++H++  T A+L   G + +E  G
Sbjct: 990  PRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRG 1036


>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
          Length = 732

 Score =  113 bits (283), Expect = 8e-25
 Identities = 65/207 (31%), Positives = 114/207 (55%), Gaps = 19/207 (9%)

Query: 212 SRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQG 271
           + + L+ EKK    LL SI P  +A+++           QG + ++         ++   
Sbjct: 479 THQALEEEKKKTVDLLYSIFPGDVAQQL----------WQGQQVQA---------RKFDD 519

Query: 272 VSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLP 331
           V++L++DIVGFT + ++C+P +++ MLNEL+ +FD      +  +++ +GD Y   +GL 
Sbjct: 520 VTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLH 579

Query: 332 LSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSH 391
                HA     M L M     ++    G  I MR+G+HSGSVL GV+G++  +Y ++ +
Sbjct: 580 RKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGN 639

Query: 392 DVTLANHMEAGGVPGRVHITGATLALL 418
           +VTLA+  E+G  P R++++  T  LL
Sbjct: 640 NVTLASKFESGSHPRRINVSPTTYQLL 666



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 54/218 (24%), Positives = 101/218 (46%), Gaps = 23/218 (10%)

Query: 815  RLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCV 874
            R+D L K  L +  +  E  +  T  LL ++ P  VA Q      + + +  + ++ V +
Sbjct: 468  RMDKL-KATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTM 522

Query: 875  LFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAA 934
            LF+ +  F    ++       ++ + +LNE+   FD       F  + K++TIG  Y  A
Sbjct: 523  LFSDIVGFTAICAQCT----PMQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVA 575

Query: 935  TGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVA 994
             GL+            +S  H   +   A+ +    + +        ++R+G++ G V+A
Sbjct: 576  AGLH-----------RKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLA 624

Query: 995  GVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEET 1032
            GV+G + P+Y ++GN V +AS+ ES     +I V+  T
Sbjct: 625  GVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT 662


>gi|134152694 guanylate cyclase 2F [Homo sapiens]
          Length = 1108

 Score =  110 bits (276), Expect = 5e-24
 Identities = 81/242 (33%), Positives = 128/242 (52%), Gaps = 23/242 (9%)

Query: 824  LRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFK 883
            +R+  EE E  +  T  LL  +LP  VA       ++   +  + ++ V + F+ +  F 
Sbjct: 839  IRERTEELEIEKQKTEKLLTQMLPPSVAESL----KKGCTVEPEGFDLVTLYFSDIVGFT 894

Query: 884  EFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSG- 942
               + S    E +E + LLN++   FD ++       V K++TIG  YM A+GL   +G 
Sbjct: 895  TISAMS----EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPKRNGS 947

Query: 943  QDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKP 1002
            + A + A  S   L ++  F +    ++ V         R+R+GL+ GPVVAGV+G   P
Sbjct: 948  RHAAEIANMSLDILSSVGTFKMRHMPEVPV---------RIRIGLHSGPVVAGVVGLTMP 998

Query: 1003 QYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL--GYTCYSRGVIKVKGKGQLCTY 1060
            +Y ++G+TVN ASRMESTG+  +I V+  T   LQ+L  GY    RG  ++KGKG   T+
Sbjct: 999  RYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETF 1058

Query: 1061 FL 1062
            +L
Sbjct: 1059 WL 1060



 Score =  107 bits (266), Expect = 8e-23
 Identities = 70/219 (31%), Positives = 116/219 (52%), Gaps = 25/219 (11%)

Query: 216  LDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVL 275
            L+ EK+  E LL  +LP  +A  +K         G    PE  +            V++ 
Sbjct: 846  LEIEKQKTEKLLTQMLPPSVAESLKK--------GCTVEPEGFDL-----------VTLY 886

Query: 276  YADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLP-LSL 334
            ++DIVGFT +++   P E+V +LN+L+  FD I   H+  +++ +GD Y   SGLP  + 
Sbjct: 887  FSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNG 946

Query: 335  PDHAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHD 392
              HA     M LD+  ++   K+R    V + +R+G+HSG V+ GV+GL   +Y ++   
Sbjct: 947  SRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDT 1006

Query: 393  VTLANHMEAGGVPGRVHITGATLAL---LAGAYAVEDAG 428
            V  A+ ME+ G+P R+H++ +T+ +   L+  Y VE  G
Sbjct: 1007 VNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRG 1045


>gi|222080083 guanylate cyclase 2C [Homo sapiens]
          Length = 1073

 Score =  110 bits (275), Expect = 7e-24
 Identities = 66/213 (30%), Positives = 118/213 (55%), Gaps = 14/213 (6%)

Query: 214 RRLDTEKKHQEHLLLSILPAYLAREMKAE-----IMARLQAGQGSRPESTNNFHSLYVKR 268
           RRL    ++ EHL+      Y A   +A+     ++ RL        +S      +  + 
Sbjct: 766 RRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVV------KSLKEKGFVEPEL 819

Query: 269 HQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVS 328
           ++ V++ ++DIVGFT +    +P E+V MLN+++  FD I   H+  +++ +GD Y   S
Sbjct: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879

Query: 329 GLPLSLPD-HAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQKWQ 385
           GLP    + HAI+  +M L++   +   +L    G+ I +R+GVHSG    GV+G++  +
Sbjct: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939

Query: 386 YDVWSHDVTLANHMEAGGVPGRVHITGATLALL 418
           Y ++   V  A+ ME+ G+P R+H++G+T+A+L
Sbjct: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL 972



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 74/262 (28%), Positives = 127/262 (48%), Gaps = 30/262 (11%)

Query: 806  LARQNEYYCR-LDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDL 864
            L R+ + Y R L+ L +++ +  + E +  + L  +LL         P+ + ++ + +  
Sbjct: 764  LIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLL---------PRLVVKSLKEKGF 814

Query: 865  YH-QSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEK 923
               + YE V + F+ +  F      S      +E + +LN+I   FD ++       V K
Sbjct: 815  VEPELYEEVTIYFSDIVGFTTICKYST----PMEVVDMLNDIYKSFDHIVDH---HDVYK 867

Query: 924  IKTIGSTYMAATGLNATSGQDAQQD-AERSCSHLGTMVEFAVALGSKLDVINKHSFNNFR 982
            ++TIG  YM A+GL   +G     D A+ +   L  M  F +     L +          
Sbjct: 868  VETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIW--------- 918

Query: 983  LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQ--SLG 1040
            +R+G++ GP  AGV+G + P+Y ++G+TVN ASRMESTG+  +I V+  T   L+     
Sbjct: 919  IRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQ 978

Query: 1041 YTCYSRGVIKVKGKGQLCTYFL 1062
            +    RG   +KG+G   TY+L
Sbjct: 979  FLYEVRGETYLKGRGNETTYWL 1000


>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
            sapiens]
          Length = 1103

 Score =  107 bits (266), Expect = 8e-23
 Identities = 81/242 (33%), Positives = 124/242 (51%), Gaps = 23/242 (9%)

Query: 824  LRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFK 883
            +R+  EE E  +  T  LL  +LP  VA       +    +  + +E V + F+ +  F 
Sbjct: 835  IRERTEELELEKQKTDRLLTQMLPPSVAEAL----KTGTPVEPEYFEQVTLYFSDIVGFT 890

Query: 884  EFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQ 943
               + S    E +E + LLN++   FD ++       V K++TIG  YM A+GL   +GQ
Sbjct: 891  TISAMS----EPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPQRNGQ 943

Query: 944  -DAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKP 1002
              A + A  S   L  +  F +    ++ V         R+R+GL+ GP VAGV+G   P
Sbjct: 944  RHAAEIANMSLDILSAVGTFRMRHMPEVPV---------RIRIGLHSGPCVAGVVGLTMP 994

Query: 1003 QYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSL--GYTCYSRGVIKVKGKGQLCTY 1060
            +Y ++G+TVN ASRMESTG+  +I V   T   L++L  GY    RG  ++KGKG   T+
Sbjct: 995  RYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTF 1054

Query: 1061 FL 1062
            +L
Sbjct: 1055 WL 1056



 Score =  105 bits (261), Expect = 3e-22
 Identities = 68/219 (31%), Positives = 113/219 (51%), Gaps = 25/219 (11%)

Query: 216  LDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVL 275
            L+ EK+  + LL  +LP  +A  +K         G    PE             + V++ 
Sbjct: 842  LELEKQKTDRLLTQMLPPSVAEALKT--------GTPVEPEY-----------FEQVTLY 882

Query: 276  YADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLP-LSL 334
            ++DIVGFT +++   P E+V +LN+L+  FD I   H+  +++ +GD Y   SGLP  + 
Sbjct: 883  FSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNG 942

Query: 335  PDHAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHD 392
              HA     M LD+  A+   ++R    V + +R+G+HSG  + GV+GL   +Y ++   
Sbjct: 943  QRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDT 1002

Query: 393  VTLANHMEAGGVPGRVHITGATLALLA---GAYAVEDAG 428
            V  A+ ME+ G+P R+H+  +T+ +L      Y VE  G
Sbjct: 1003 VNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRG 1041


>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
          Length = 619

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 80/255 (31%), Positives = 127/255 (49%), Gaps = 31/255 (12%)

Query: 822  KKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPD 881
            + L  E+++T+T       LL +VLP  VA +     R    +  + Y+ V +LF+ +  
Sbjct: 381  RALEDEKKKTDT-------LLYSVLPPSVANEL----RHKRPVPAKRYDNVTILFSGIVG 429

Query: 882  FKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATS 941
            F  F S+       ++ + LLN++   FD L    K   V K++T+G  YM  +GL    
Sbjct: 430  FNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPC 489

Query: 942  GQDAQQDAERSCSHLGT-MVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQ 1000
               A     RS  HL   M+E A     ++ V  +    + ++ +G++ G VV GVIG +
Sbjct: 490  IHHA-----RSICHLALDMMEIA----GQVQVDGE----SVQITIGIHTGEVVTGVIGQR 536

Query: 1001 KPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQS-----LGYTCYSRGVIKVKGKG 1055
             P+Y ++GNTVN+ SR E+TG  GKI V+E T   L S       +    RG + +KGK 
Sbjct: 537  MPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKK 596

Query: 1056 Q-LCTYFLNTDLTRT 1069
            + +  +FL+   T T
Sbjct: 597  EPMQVWFLSRKNTGT 611



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 64/229 (27%), Positives = 116/229 (50%), Gaps = 28/229 (12%)

Query: 214 RRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVS 273
           R L+ EKK  + LL S+LP  +A E++ +           RP        +  KR+  V+
Sbjct: 381 RALEDEKKKTDTLLYSVLPPSVANELRHK-----------RP--------VPAKRYDNVT 421

Query: 274 VLYADIVGFTRLASECSPKE----LVLMLNELFGKFDQIAKEHE---CMRIKILGDCYYC 326
           +L++ IVGF    S+ +  E    +V +LN+L+ +FD +    +     +++ +GD Y  
Sbjct: 422 ILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMT 481

Query: 327 VSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQY 386
           VSGLP     HA +   + LDM     +++   G  + + +G+H+G V+ GVIG +  +Y
Sbjct: 482 VSGLPEPCIHHARSICHLALDMMEIAGQVQV-DGESVQITIGIHTGEVVTGVIGQRMPRY 540

Query: 387 DVWSHDVTLANHMEAGGVPGRVHITGATL-ALLAGAYAVEDAGMEHRDP 434
            ++ + V L +  E  G  G+++++  T   L++   +     +EHR P
Sbjct: 541 CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGP 589


>gi|209976994 adenylate cyclase 10 [Homo sapiens]
          Length = 1610

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 27/84 (32%), Positives = 39/84 (46%), Gaps = 12/84 (14%)

Query: 321 GDCYYCVSGLP-LSLPD---HAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLC 376
           G  + CV G P   +PD   HA+ C     D C  + K++  +       +GV SG V C
Sbjct: 341 GCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVS-------IGVASGIVFC 393

Query: 377 GVIG-LQKWQYDVWSHDVTLANHM 399
           G++G   + +Y V    V LA  M
Sbjct: 394 GIVGHTVRHEYTVIGQKVNLAARM 417


>gi|4507381 thromboxane A2 receptor [Homo sapiens]
          Length = 343

 Score = 34.7 bits (78), Expect = 0.50
 Identities = 32/108 (29%), Positives = 43/108 (39%), Gaps = 14/108 (12%)

Query: 61  FLTTVLCALGGFSLLLGLASREQRLQRWTRPLS--------------GLVWVALLALGHA 106
           F+  V+   G   LLLG A   +R    TRP S              GLVW A LALG  
Sbjct: 107 FMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLL 166

Query: 107 FLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLL 154
            L   G  +     S+    +      +  G+  + + GL+  LS LL
Sbjct: 167 PLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLL 214


>gi|30581164 neuropeptides B/W receptor 2 [Homo sapiens]
          Length = 333

 Score = 32.0 bits (71), Expect = 3.2
 Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 10/116 (8%)

Query: 22  SLSQQYPLLLLLLGIV---LCALA-----ALLAVAWASGRELTSDPSFLTTVLCALGGFS 73
           + S+  P L +LL  V   +CA+      A++ V   + +  T    F+  +  A G F+
Sbjct: 36  TFSEPLPFLYVLLPAVYSGICAVGLTGNTAVILVILRAPKMKTVTNVFILNLAVADGLFT 95

Query: 74  LLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFT 129
           L+L +   E  LQ W  P   L+   +LA+ H  +F+     A   V  +L V+ T
Sbjct: 96  LVLPVNIAEHLLQYW--PFGELLCKLVLAVDHYNIFSSIYFLAVMSVDRYLVVLAT 149


>gi|28872720 purinergic receptor P2Y2 [Homo sapiens]
          Length = 377

 Score = 31.6 bits (70), Expect = 4.2
 Identities = 37/127 (29%), Positives = 51/127 (40%), Gaps = 21/127 (16%)

Query: 20  YYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLC--ALGGFSLLLG 77
           YY+    +P        VLC L   L         L     FLT +     LG   +L  
Sbjct: 92  YYARGDHWPF-----STVLCKLVRFLFYT-----NLYCSILFLTCISVHRCLG---VLRP 138

Query: 78  LASREQRLQRWTRPLSGLVWVALLALGHAFLF------TGGVVSAWDQVSYFLFVIFTAY 131
           L S      R+ R ++G VWV +LA     L+       GG V+  D  +  LF  F AY
Sbjct: 139 LRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAY 198

Query: 132 AMLPLGM 138
           + + LG+
Sbjct: 199 SSVMLGL 205


>gi|28872745 purinergic receptor P2Y2 [Homo sapiens]
          Length = 377

 Score = 31.6 bits (70), Expect = 4.2
 Identities = 37/127 (29%), Positives = 51/127 (40%), Gaps = 21/127 (16%)

Query: 20  YYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLC--ALGGFSLLLG 77
           YY+    +P        VLC L   L         L     FLT +     LG   +L  
Sbjct: 92  YYARGDHWPF-----STVLCKLVRFLFYT-----NLYCSILFLTCISVHRCLG---VLRP 138

Query: 78  LASREQRLQRWTRPLSGLVWVALLALGHAFLF------TGGVVSAWDQVSYFLFVIFTAY 131
           L S      R+ R ++G VWV +LA     L+       GG V+  D  +  LF  F AY
Sbjct: 139 LRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAY 198

Query: 132 AMLPLGM 138
           + + LG+
Sbjct: 199 SSVMLGL 205


>gi|28872743 purinergic receptor P2Y2 [Homo sapiens]
          Length = 377

 Score = 31.6 bits (70), Expect = 4.2
 Identities = 37/127 (29%), Positives = 51/127 (40%), Gaps = 21/127 (16%)

Query: 20  YYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLC--ALGGFSLLLG 77
           YY+    +P        VLC L   L         L     FLT +     LG   +L  
Sbjct: 92  YYARGDHWPF-----STVLCKLVRFLFYT-----NLYCSILFLTCISVHRCLG---VLRP 138

Query: 78  LASREQRLQRWTRPLSGLVWVALLALGHAFLF------TGGVVSAWDQVSYFLFVIFTAY 131
           L S      R+ R ++G VWV +LA     L+       GG V+  D  +  LF  F AY
Sbjct: 139 LRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAY 198

Query: 132 AMLPLGM 138
           + + LG+
Sbjct: 199 SSVMLGL 205


>gi|8923657 solute carrier family 35, member A5 [Homo sapiens]
          Length = 424

 Score = 31.6 bits (70), Expect = 4.2
 Identities = 29/114 (25%), Positives = 50/114 (43%), Gaps = 18/114 (15%)

Query: 558 KDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYS 617
           KD     L +   +   ++   +IPAF Y        FL N I+  +++   PA+A+ +S
Sbjct: 76  KDHQSRNLKYASWKEFSDFMKWSIPAFLY--------FLDNLIVFYVLSYLQPAMAVIFS 127

Query: 618 ITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATI 671
              ++   +LF        R VLK  + L+W+   S L      + +  GT T+
Sbjct: 128 NFSIITTALLF--------RIVLK--RRLNWIQWASLLTLFLSIVALTAGTKTL 171


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,530,476
Number of Sequences: 37866
Number of extensions: 1827545
Number of successful extensions: 4565
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 4396
Number of HSP's gapped (non-prelim): 60
length of query: 1077
length of database: 18,247,518
effective HSP length: 113
effective length of query: 964
effective length of database: 13,968,660
effective search space: 13465788240
effective search space used: 13465788240
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.