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Search of human proteins with 24041040
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
(787 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 1704 0.0
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 1690 0.0
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 648 0.0
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 593 e-169
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 585 e-167
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 481 e-135
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 479 e-135
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 479 e-135
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 477 e-134
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 471 e-133
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 468 e-131
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 432 e-121
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 395 e-110
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 382 e-106
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot... 341 2e-93
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 328 2e-89
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s... 325 1e-88
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 311 2e-84
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 309 6e-84
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 307 2e-83
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 307 2e-83
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 307 2e-83
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 307 2e-83
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 307 2e-83
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 296 4e-80
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 292 9e-79
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 288 1e-77
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 288 1e-77
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 288 1e-77
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 288 1e-77
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 1704 bits (4413), Expect = 0.0
Identities = 787/787 (100%), Positives = 787/787 (100%)
Query: 1 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 60
MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
Sbjct: 1 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 60
Query: 61 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV 120
SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
Sbjct: 61 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV 120
Query: 121 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG 180
RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG
Sbjct: 121 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG 180
Query: 181 HRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEV 240
HRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEV
Sbjct: 181 HRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEV 240
Query: 241 ANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQL 300
ANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQL
Sbjct: 241 ANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQL 300
Query: 301 LTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGC 360
LTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGC
Sbjct: 301 LTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGC 360
Query: 361 CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALC 420
CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALC
Sbjct: 361 CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALC 420
Query: 421 GNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMG 480
GNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMG
Sbjct: 421 GNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMG 480
Query: 481 DCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEA 540
DCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEA
Sbjct: 481 DCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEA 540
Query: 541 CFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLD 600
CFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLD
Sbjct: 541 CFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLD 600
Query: 601 GQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCDKPGFG 660
GQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCDKPGFG
Sbjct: 601 GQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCDKPGFG 660
Query: 661 GSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACS 720
GSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACS
Sbjct: 661 GSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACS 720
Query: 721 GPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQ 780
GPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQ
Sbjct: 721 GPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQ 780
Query: 781 MPRSCLW 787
MPRSCLW
Sbjct: 781 MPRSCLW 787
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 1690 bits (4376), Expect = 0.0
Identities = 787/813 (96%), Positives = 787/813 (96%), Gaps = 26/813 (3%)
Query: 1 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 60
MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV
Sbjct: 1 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 60
Query: 61 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV 120
SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV
Sbjct: 61 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV 120
Query: 121 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG 180
RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG
Sbjct: 121 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG 180
Query: 181 HRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEV 240
HRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEV
Sbjct: 181 HRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEV 240
Query: 241 ANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQL 300
ANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQL
Sbjct: 241 ANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQL 300
Query: 301 LTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGC 360
LTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGC
Sbjct: 301 LTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGC 360
Query: 361 CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALC 420
CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALC
Sbjct: 361 CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALC 420
Query: 421 GNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMG 480
GNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMG
Sbjct: 421 GNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMG 480
Query: 481 DCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEA 540
DCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEA
Sbjct: 481 DCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEA 540
Query: 541 CFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLD 600
CFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLD
Sbjct: 541 CFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLD 600
Query: 601 GQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRM------------------------- 635
GQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRM
Sbjct: 601 GQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSH 660
Query: 636 -VCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGL 694
VCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGL
Sbjct: 661 GVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGL 720
Query: 695 AWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPE 754
AWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPE
Sbjct: 721 AWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPE 780
Query: 755 NSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 787
NSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
Sbjct: 781 NSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 813
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 648 bits (1672), Expect = 0.0
Identities = 327/710 (46%), Positives = 430/710 (60%), Gaps = 44/710 (6%)
Query: 15 LLLLLLLLWPV-PGA----GVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVA 69
L LL L P+ P A G +G G P H ++ Q W+T P +
Sbjct: 10 LCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQ-WKTSESPVREKHPLKAELR 68
Query: 70 LEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVV 129
+ AEG+EL+L+LEKN +L AP Y ETHY G P DHC Y G VR S V
Sbjct: 69 VMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVT 128
Query: 130 LCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG--HRDPGNK 187
L TC G+ GLIT+S N SY + P P + H I+R E L G CG H P +
Sbjct: 129 LSTCRGIRGLITVSSNLSYVIEPLPDSKGQ----HLIYRSEHLKPPPGNCGFEHSKPTTR 184
Query: 188 AGMTSLPGGPQSRGRREARR---TRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
+ R RR R + KY+ELY+VAD+ F R+ + TK +L+E+ANYV
Sbjct: 185 DWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYV 244
Query: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGR 304
D+ R+L+I++AL GLEVWT + V+++ +TLW+FL WRR L AQ+ HD+AQL+TG
Sbjct: 245 DKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGM 304
Query: 305 AFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEA 364
+F G T+GLAP+ MC SGGV+ DHSE IG AATMAHE+GH+ G++HD CC +
Sbjct: 305 SFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSAS 364
Query: 365 AAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGF 424
AA+ GGC+MAAATGHPFP+VF+ C+RR+L + + GGG CLSN PD + CGNG+
Sbjct: 365 AAD-GGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGY 423
Query: 425 VEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDL 484
+E GEECDCG +EC + CC A NC+LRPGA+CAHG CC +C L G LCR+ CDL
Sbjct: 424 LEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDL 483
Query: 485 PEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQV 544
PEFCTG S HCP + Y +DG+PC G YC++G C T ++QCQQLWGPG+ PAP+ CF+
Sbjct: 484 PEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEK 543
Query: 545 VNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEV 604
VN AGD GNCG+D G C RDA CGK+QCQ + L + VP+D+T+ ++G+++
Sbjct: 544 VNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQI 603
Query: 605 TCRGALAL--PSAQLDLLGLGLVEPGTQCG--------------------------PRMV 636
CRG P + D+L GLV GT+CG V
Sbjct: 604 QCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGV 663
Query: 637 CNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLL 686
CN+N NCHC PGWAPPFC+ PG GGS+DSGP+ E+ + +L+++L+
Sbjct: 664 CNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILV 713
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 593 bits (1529), Expect = e-169
Identities = 347/865 (40%), Positives = 459/865 (53%), Gaps = 115/865 (13%)
Query: 13 LLLLLLLLLLWPVPGAGV-LQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALE 71
LLL L LL P GV L V V G W V + + P++ + L+
Sbjct: 14 LLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQ 73
Query: 72 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT---DHCHYQGRVRGFPDSWV 128
E +EL++ LE+N L+A + ETHY DG V LA N+T HC+Y G VRG+ DS V
Sbjct: 74 RESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAV 133
Query: 129 VLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG-HRDPGNK 187
L TCSG+ GLI N SY L P ++ +++F ++L + +G+CG H + N
Sbjct: 134 SLSTCSGLRGLIVFE-NESYVLEPMKSATNR----YKLFPAKKLKSVRGSCGSHHNTPNL 188
Query: 188 AGMTSLPGGPQSRGRREARRT---RKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
A P Q+ RR R T KY+EL IVAD+ F + ++L KQRL+E+AN+V
Sbjct: 189 AAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
Query: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRR-GLWAQRPHDSAQLLTG 303
D+ R L+I++ L G+EVW + D+ V+QD +L FL WR+ L ++ HD+AQL++G
Sbjct: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
Query: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP--DGCC 361
FQG T+G+AP+ MC A+ SGG+ DHS+ P+GAA T+AHE+GH+ G++HD GC
Sbjct: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
Query: 362 VEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCG 421
+ A E GGC+M A+TG+PFP VFS+CSR+ L KG G CL N P+ CG
Sbjct: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCG 428
Query: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
N FVE GEECDCG +EC + CC A C+L+P A CAHG CC C LKPAG CR +
Sbjct: 429 NRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNS 488
Query: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
CDLPEFCTG S HCP +VYL DG C GYC++G C T EQQC LWGPG+ PAP C
Sbjct: 489 CDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGIC 548
Query: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGG-KPSLLAPHMVPVDSTVHL- 599
F+ VNSAGD +GNCG+ S+ F C RDA CGK+QCQGG ++ + V +++ + L
Sbjct: 549 FERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQ 608
Query: 600 DGQEVTCRGALA-----LPSAQLDLLG-------------------LGLVEPGTQCGPRM 635
G + CRG +P L L G G+ E QC R
Sbjct: 609 QGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRG 668
Query: 636 VCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLL--------- 686
VCN+ NCHC WAPPFCDK GFGGS DSGP++ ++ + +L+++L
Sbjct: 669 VCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVY 728
Query: 687 -------------------------PLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACS- 720
P P G C AHL G R P S
Sbjct: 729 LKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPC-----QAHLGHLGKGLMRKPPDSY 783
Query: 721 GPKDGPHR---------DHPLGG---------------VHPMELGPTATGQPWPLDP--- 753
PKD P R PL G +H P+ +P P P
Sbjct: 784 PPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALR 843
Query: 754 --ENSHEPSSHPEKPLPAVSPDPQA 776
+ + +P+ P+KPLPA DP A
Sbjct: 844 QAQGTCKPNP-PQKPLPA---DPLA 864
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 585 bits (1507), Expect = e-167
Identities = 314/697 (45%), Positives = 410/697 (58%), Gaps = 43/697 (6%)
Query: 13 LLLLLLLLLLWPVPGAGV-LQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALE 71
LLL L LL P GV L V V G W V + + P++ + L+
Sbjct: 14 LLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQ 73
Query: 72 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT---DHCHYQGRVRGFPDSWV 128
E +EL++ LE+N L+A + ETHY DG V LA N+T HC+Y G VRG+ DS V
Sbjct: 74 RESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAV 133
Query: 129 VLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG-HRDPGNK 187
L TCSG+ GLI N SY L P ++ +++F ++L + +G+CG H + N
Sbjct: 134 SLSTCSGLRGLIVFE-NESYVLEPMKSATNR----YKLFPAKKLKSVRGSCGSHHNTPNL 188
Query: 188 AGMTSLPGGPQSRGRREARRT---RKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
A P Q+ RR R T KY+EL IVAD+ F + ++L KQRL+E+AN+V
Sbjct: 189 AAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
Query: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRR-GLWAQRPHDSAQLLTG 303
D+ R L+I++ L G+EVW + D+ V+QD +L FL WR+ L ++ HD+AQL++G
Sbjct: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
Query: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP--DGCC 361
FQG T+G+AP+ MC A+ SGG+ DHS+ P+GAA T+AHE+GH+ G++HD GC
Sbjct: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
Query: 362 VEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCG 421
+ A E GGC+M A+TG+PFP VFS+CSR+ L KG G CL N P+ CG
Sbjct: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCG 428
Query: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
N FVE GEECDCG +EC + CC A C+L+P A CAHG CC C LKPAG CR +
Sbjct: 429 NRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNS 488
Query: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
CDLPEFCTG S HCP +VYL DG C GYC++G C T EQQC LWGPG+ PAP C
Sbjct: 489 CDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGIC 548
Query: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGG-KPSLLAPHMVPVDSTVHL- 599
F+ VNSAGD +GNCG+ S+ F C RDA CGK+QCQGG ++ + V +++ + L
Sbjct: 549 FERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQ 608
Query: 600 DGQEVTCRGALA-----LPSAQLDLLG-------------------LGLVEPGTQCGPRM 635
G + CRG +P L L G G+ E QC R
Sbjct: 609 QGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRG 668
Query: 636 VCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV-QAE 671
VCN+ NCHC WAPPFCDK GFGGS DSGP+ QAE
Sbjct: 669 VCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAE 705
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 481 bits (1237), Expect = e-135
Identities = 314/808 (38%), Positives = 409/808 (50%), Gaps = 70/808 (8%)
Query: 23 WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74
WP+P G + P +P+ P + D P +SL++ + S P+ + LE +G
Sbjct: 21 WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
Query: 75 QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134
+LEL +N L+ Y PDG VV + ++C YQGRVRG+ SWV +CTCS
Sbjct: 78 DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
Query: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191
G+ GL+ L+ SY L +G D I Q L G TC R+ +
Sbjct: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
Query: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250
P G + R RR+ K +EL IVADH+ ++R+ H R LEVA +D R
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
Query: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309
L+++VAL GLE WT+RD ++ + TL FL WRR L + PHDSAQL+TG +F G
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367
TVG+A +C + SGGV+ DHS +G A+++AHE+GHSLGL HD G C A
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427
+ C+M A+T FS CSRR L G G+CL P LP A CGN FVE
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
Query: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486
GE+CDCG +C D CC + C LRPGAQCA G CC C L+P+G CR GDCDLPE
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
Query: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546
FC G SS CPPDV L DG PCA G C G C + QQCQ LWGPG+ PA C Q N
Sbjct: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
Query: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605
+ G+A G+CG++ G ++ C RDA+CG+LQCQ G+ LL + T+ ++G E+
Sbjct: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
Query: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRM--------------------------VCN 638
C L L S D+ L PGT CGP + VC+
Sbjct: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
Query: 639 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 698
SN +C+C GWAPP C + ++A + T L + L VLL L+ W
Sbjct: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
Query: 699 YRLPGAHLQRCSWGCRRDPACSGPKD--GPHRDHPLGGVHPMELG--PTATGQPWPLDPE 754
RL Q C+ A SGP + GP + L EL P +P P DP
Sbjct: 719 ARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKAELADRPNPPTRPLPADPV 778
Query: 755 NSHEPSSHPEKPLPAVSPDPQADQVQMP 782
S P KP P P P Q + P
Sbjct: 779 VRSPKSQGPAKPPPPRKPLPADPQGRCP 806
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 479 bits (1233), Expect = e-135
Identities = 311/810 (38%), Positives = 410/810 (50%), Gaps = 70/810 (8%)
Query: 23 WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74
WP+P G + P +P+ P + D P +SL++ + S P+ + LE +G
Sbjct: 21 WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
Query: 75 QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134
+LEL +N L+ Y PDG VV + ++C YQGRVRG+ SWV +CTCS
Sbjct: 78 DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
Query: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191
G+ GL+ L+ SY L +G D I Q L G TC R+ +
Sbjct: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
Query: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250
P G + R RR+ K +EL IVADH+ ++R+ H R LEVA +D R
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
Query: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309
L+++VAL GLE WT+RD ++ + TL FL WRR L + PHDSAQL+TG +F G
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367
TVG+A +C + SGGV+ DHS +G A+++AHE+GHSLGL HD G C A
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427
+ C+M A+T FS CSRR L G G+CL P LP A CGN FVE
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
Query: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486
GE+CDCG +C D CC + C LRPGAQCA G CC C L+P+G CR GDCDLPE
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
Query: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546
FC G SS CPPDV L DG PCA G C G C + QQCQ LWGPG+ PA C Q N
Sbjct: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
Query: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605
+ G+A G+CG++ G ++ C RDA+CG+LQCQ G+ LL + T+ ++G E+
Sbjct: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
Query: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRM--------------------------VCN 638
C L L S D+ L PGT CGP + VC+
Sbjct: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
Query: 639 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 698
SN +C+C GWAPP C + ++A + T L + L VLL L+ W
Sbjct: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
Query: 699 YRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELG-PTATGQPWPLDPE 754
RL Q C+ A SGP + P R G L P +P P DP
Sbjct: 719 ARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKASALSFPAPPSRPLPPDPV 778
Query: 755 NSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784
+ + ++P P P P V+ P+S
Sbjct: 779 SKRLQAELADRPNPPTRPLPADPVVRSPKS 808
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 479 bits (1232), Expect = e-135
Identities = 314/809 (38%), Positives = 410/809 (50%), Gaps = 71/809 (8%)
Query: 23 WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74
WP+P G + P +P+ P + D P +SL++ + S P+ + LE +G
Sbjct: 21 WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
Query: 75 QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134
+LEL +N L+ Y PDG VV + ++C YQGRVRG+ SWV +CTCS
Sbjct: 78 DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
Query: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191
G+ GL+ L+ SY L +G D I Q L G TC R+ +
Sbjct: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
Query: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250
P G + R RR+ K +EL IVADH+ ++R+ H R LEVA +D R
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
Query: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309
L+++VAL GLE WT+RD ++ + TL FL WRR L + PHDSAQL+TG +F G
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367
TVG+A +C + SGGV+ DHS +G A+++AHE+GHSLGL HD G C A
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427
+ C+M A+T FS CSRR L G G+CL P LP A CGN FVE
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
Query: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486
GE+CDCG +C D CC + C LRPGAQCA G CC C L+P+G CR GDCDLPE
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
Query: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546
FC G SS CPPDV L DG PCA G C G C + QQCQ LWGPG+ PA C Q N
Sbjct: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
Query: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605
+ G+A G+CG++ G ++ C RDA+CG+LQCQ G+ LL + T+ ++G E+
Sbjct: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
Query: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRM--------------------------VCN 638
C L L S D+ L PGT CGP + VC+
Sbjct: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
Query: 639 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 698
SN +C+C GWAPP C + ++A + T L + L VLL L+ W
Sbjct: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
Query: 699 YRLPGAHLQRCSWGCRRDPACSGPKD--GPHRDHPL--GGVHPMELG-PTATGQPWPLDP 753
RL Q C+ A SGP + GP + L G L P +P P DP
Sbjct: 719 ARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDP 778
Query: 754 ENSHEPSSHPEKPLPAVSPDPQADQVQMP 782
+ S P KP P P P Q + P
Sbjct: 779 VSKRLQSQGPAKPPPPRKPLPADPQGRCP 807
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 477 bits (1228), Expect = e-134
Identities = 312/811 (38%), Positives = 412/811 (50%), Gaps = 71/811 (8%)
Query: 23 WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74
WP+P G + P +P+ P + D P +SL++ + S P+ + LE +G
Sbjct: 21 WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
Query: 75 QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134
+LEL +N L+ Y PDG VV + ++C YQGRVRG+ SWV +CTCS
Sbjct: 78 DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
Query: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191
G+ GL+ L+ SY L +G D I Q L G TC R+ +
Sbjct: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
Query: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250
P G + R RR+ K +EL IVADH+ ++R+ H R LEVA +D R
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
Query: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309
L+++VAL GLE WT+RD ++ + TL FL WRR L + PHDSAQL+TG +F G
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367
TVG+A +C + SGGV+ DHS +G A+++AHE+GHSLGL HD G C A
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427
+ C+M A+T FS CSRR L G G+CL P LP A CGN FVE
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
Query: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486
GE+CDCG +C D CC + C LRPGAQCA G CC C L+P+G CR GDCDLPE
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
Query: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546
FC G SS CPPDV L DG PCA G C G C + QQCQ LWGPG+ PA C Q N
Sbjct: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
Query: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605
+ G+A G+CG++ G ++ C RDA+CG+LQCQ G+ LL + T+ ++G E+
Sbjct: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
Query: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRM--------------------------VCN 638
C L L S D+ L PGT CGP + VC+
Sbjct: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
Query: 639 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 698
SN +C+C GWAPP C + ++A + T L + L VLL L+ W
Sbjct: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
Query: 699 YRLPGAHLQRCSWGCRRDPACSGPKD--GPHRDHPL--GGVHPMELG-PTATGQPWPLDP 753
RL Q C+ A SGP + GP + L G L P +P P DP
Sbjct: 719 ARLHQRLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKQASALSFPAPPSRPLPPDP 778
Query: 754 ENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784
+ + ++P P P P V+ P+S
Sbjct: 779 VSKRLQAELADRPNPPTRPLPADPVVRSPKS 809
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 471 bits (1213), Expect = e-133
Identities = 310/797 (38%), Positives = 402/797 (50%), Gaps = 83/797 (10%)
Query: 23 WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74
WP+P G + P +P+ P + D P +SL++ + S P+ + LE +G
Sbjct: 21 WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
Query: 75 QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134
+LEL +N L+ Y PDG VV + ++C YQGRVRG+ SWV +CTCS
Sbjct: 78 DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
Query: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191
G+ GL+ L+ SY L +G D I Q L G TC R+ +
Sbjct: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
Query: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250
P G + R RR+ K +EL IVADH+ ++R+ H R LEVA +D R
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
Query: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309
L+++VAL GLE WT+RD ++ + TL FL WRR L + PHDSAQL+TG +F G
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367
TVG+A +C + SGGV+ DHS +G A+++AHE+GHSLGL HD G C A
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427
+ C+M A+T FS CSRR L G G+CL P LP A CGN FVE
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
Query: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486
GE+CDCG +C D CC + C LRPGAQCA G CC C L+P+G CR GDCDLPE
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
Query: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546
FC G SS CPPDV L DG PCA G C G C + QQCQ LWGPG+ PA C Q N
Sbjct: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
Query: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605
+ G+A G+CG++ G ++ C RDA+CG+LQCQ G+ LL + T+ ++G E+
Sbjct: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
Query: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRM--------------------------VCN 638
C L L S D+ L PGT CGP + VC+
Sbjct: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
Query: 639 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 698
SN +C+C GWAPP C + ++A + T L + L VLL L+ W
Sbjct: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
Query: 699 YRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHE 758
RL Q C+ A SGP + P G L T P P
Sbjct: 719 ARLHQRLCQLKGPTCQYRAAQSGPSERP-------GPPQRALLARGTKSQGPAKP----- 766
Query: 759 PSSHPEKPLPAVSPDPQ 775
P KPLPA DPQ
Sbjct: 767 --PPPRKPLPA---DPQ 778
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 468 bits (1203), Expect = e-131
Identities = 297/755 (39%), Positives = 389/755 (51%), Gaps = 72/755 (9%)
Query: 23 WPVPGAGVLQGH------IPGQPVTPHWVLDGQPWRTVSLEEPV--SKPDMGLVALEAEG 74
WP+P G + P +P+ P + D P +SL++ + S P+ + LE +G
Sbjct: 21 WPLPNIGGTEEQQAESEKAPREPLEPQVLQDDLP---ISLKKVLQTSLPEPLRIKLELDG 77
Query: 75 QELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCS 134
+LEL +N L+ Y PDG VV + ++C YQGRVRG+ SWV +CTCS
Sbjct: 78 DSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTCS 137
Query: 135 GMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG-TCG--HRDPGNKAGMT 191
G+ GL+ L+ SY L +G D I Q L G TC R+ +
Sbjct: 138 GLRGLVVLTPERSYTLE----QGPGDLQGPPIISRIQDLHLPGHTCALSWRESVHTQKPP 193
Query: 192 SLPGGPQS-RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT 250
P G + R RR+ K +EL IVADH+ ++R+ H R LEVA +D R
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSE-AQKYRDFQHLLNRTLEVALLLDTFFRP 252
Query: 251 LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLLTGRAFQGA 309
L+++VAL GLE WT+RD ++ + TL FL WRR L + PHDSAQL+TG +F G
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 310 TVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDG--CCVEAAAE 367
TVG+A +C + SGGV+ DHS +G A+++AHE+GHSLGL HD G C A
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 368 SGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEA 427
+ C+M A+T FS CSRR L G G+CL P LP A CGN FVE
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERL-PSLPPMAAFCGNMFVEP 431
Query: 428 GEECDCGPGQECRDLCCFAHNCSLRPGAQCAH-GDCCVRCLLKPAGALCRQAMGDCDLPE 486
GE+CDCG +C D CC + C LRPGAQCA G CC C L+P+G CR GDCDLPE
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPE 491
Query: 487 FCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVN 546
FC G SS CPPDV L DG PCA G C G C + QQCQ LWGPG+ PA C Q N
Sbjct: 492 FCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTAN 551
Query: 547 SAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPS-LLAPHMVPVDSTVHLDGQEVT 605
+ G+A G+CG++ G ++ C RDA+CG+LQCQ G+ LL + T+ ++G E+
Sbjct: 552 TRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDVNGTELN 611
Query: 606 CRGA-LALPSAQLDLLGLGLVEPGTQCGPRM--------------------------VCN 638
C L L S D+ L PGT CGP + VC+
Sbjct: 612 CSWVHLDLGS---DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCD 668
Query: 639 SNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCC 698
SN +C+C GWAPP C + ++A + T L + L VLL L+ W
Sbjct: 669 SNRHCYCEEGWAPPDC----------TTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYR 718
Query: 699 YRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLG 733
RL H + C + P C G HP G
Sbjct: 719 ARL---HQRLCQ---LKGPTCQYSLRGQPSPHPQG 747
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 432 bits (1111), Expect = e-121
Identities = 283/771 (36%), Positives = 377/771 (48%), Gaps = 67/771 (8%)
Query: 22 LWPVPGAGVLQGHIPGQP--------VTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73
LW + GA +L P +P V W L G R P+ L A
Sbjct: 6 LWLL-GAMMLPAIAPSRPWALMEQYEVVLPWRLPGPRVRRALPSHLGLHPERVSYVLGAT 64
Query: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
G L L KN LL GY ET+ +G V P DHC YQG V G+PDS L TC
Sbjct: 65 GHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC 124
Query: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDP--GNKAG-M 190
+G+ G + + + + P G + H +++ E LL GTCG D G+ G
Sbjct: 125 AGLRGFFQVGSDL-HLIEPLDEGG--EGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPR 181
Query: 191 TSLPGGPQSRGRREARRTRKYLELYIVADHTLF--LTRHRNLNHTKQRLLEVANYVDQLL 248
T+ P+ +R TR Y+ELY+V D+ F L + H R+LEV N+VD+L
Sbjct: 182 TAAVFRPRPGDSLPSRETR-YVELYVVVDNAEFQMLGSEAAVRH---RVLEVVNHVDKLY 237
Query: 249 RTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRP-HDSAQLLTGRAFQ 307
+ L+ +V L GLE+W +DR V+ D + TL L W+ +R HD+ QL+TG F
Sbjct: 238 QKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFT 297
Query: 308 GATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD--GCCVEAA 365
G TVG A V MC + SSG V+ DHS+ P+G A TMAHE+GH+LG+ HD + GC +
Sbjct: 298 GTTVGFARVSAMC-SHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQER 356
Query: 366 AESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFV 425
E+G C+MA + G FPR+FS CS+ L +F + CL+NAPD V +CGN FV
Sbjct: 357 FEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFV 416
Query: 426 EAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLP 485
E GE+CDCGP ++CR+ CC + C L GAQCAHG CC C +KPAG LCR CDL
Sbjct: 417 ERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLE 476
Query: 486 EFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVV 545
EFC G CP D + +G+PC+ GYC++GACPTL QQCQ WGPG A E+CF
Sbjct: 477 EFCDGRHPECPEDAFQENGTPCS--GGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSY- 533
Query: 546 NSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSL--------LAPHMVPVDSTV 597
D C R +CG LQC+GG+ L + + D T
Sbjct: 534 ----DILPGCKASRY--------RADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTA 581
Query: 598 HLDGQEVTCRGA--LALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCD 655
+ E T G + DL QC VCN CHC GWAPP C
Sbjct: 582 YEPVPEGTRCGPEKVCWKGRCQDLHVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCA 641
Query: 656 KPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRR 715
K SG + F++ +L+ + + L+ AG+ YR + + R
Sbjct: 642 KLLTEVHAASGSL-----PVFVVVVLVLLAVVLVTLAGI--IVYRKARSRI------LSR 688
Query: 716 DPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKP 766
+ A PK R +PL + P G P P P++HP +P
Sbjct: 689 NVA---PKTTMGRSNPLFHQAASRV-PAKGGAPAPSRGPQELVPTTHPGQP 735
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 395 bits (1015), Expect = e-110
Identities = 253/716 (35%), Positives = 355/716 (49%), Gaps = 64/716 (8%)
Query: 16 LLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDG--QPWRTVSLEEPVSKPDMGLVA--LE 71
LLLL L+ PV GA PG T H PWR +P V+ ++
Sbjct: 17 LLLLGLVGPVLGAAR-----PGFQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQ 71
Query: 72 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLC 131
AEG+E ++ LE+N LL ++ Y +G + PN +HCHY+G V G +S + L
Sbjct: 72 AEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALS 131
Query: 132 TCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG--HRDPGNKAG 189
C G+ GL+ L NASY + P + S F H I+RM+ + CG ++D +
Sbjct: 132 DCFGLRGLLHLE-NASYGIEPL--QNSSHFE-HIIYRMDDVYKEPLKCGVSNKDIEKETA 187
Query: 190 MTSLPGGPQS----RGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVD 245
P R RR +Y+EL+IV D + RN ++ ++ +ANY+D
Sbjct: 188 KDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLD 247
Query: 246 QLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTGR 304
+ L+I++ L GLE+WT + + A L F+QWR + L +R HDSAQL+ +
Sbjct: 248 SMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKK 307
Query: 305 AFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEA 364
F G T G+A V +C +GG++ A+ +AHE+GH+LG++HD DG
Sbjct: 308 GF-GGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHD-DGRDCSC 365
Query: 365 AAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGF 424
A+S C+M + G R FS+CS GG CL N P P CGN
Sbjct: 366 GAKS--CIMNS--GASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKL 421
Query: 425 VEAGEECDCGPGQECR-DLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCD 483
V+AGEECDCG +EC D CC C L+ A+CA+GDCC C P G LCR +CD
Sbjct: 422 VDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSECD 481
Query: 484 LPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQ 543
+PE+C G+S C PDV++ +G PC YC++G C + QCQ ++G + AP+ CF
Sbjct: 482 VPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCFI 541
Query: 544 VVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQE 603
VNS GD GNCG S + CA +ALCGKLQC+ + P V + + +
Sbjct: 542 EVNSKGDRFGNCG-FSGNEYKKCATGNALCGKLQCENVQE---IPVFGIVPAIIQTPSRG 597
Query: 604 VTCRGA-LALPSAQLDLLGLGLVEPGTQCGP---------------------------RM 635
C G L S D+ G+V GT+CG
Sbjct: 598 TKCWGVDFQLGS---DVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHG 654
Query: 636 VCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFL--LAMLLSVLLPLL 689
VCNSN NCHC GWAPP C+ G+GGS+DSGP E + L + +++PL+
Sbjct: 655 VCNSNKNCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLI 710
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 382 bits (981), Expect = e-106
Identities = 220/619 (35%), Positives = 313/619 (50%), Gaps = 63/619 (10%)
Query: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
G+ +L L+KN LLAPGY ET+Y G+ + +P D C+YQG + S + TC
Sbjct: 65 GKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTC 124
Query: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRME-QLLTWKGTCG-------HRDPG 185
G+ G + + Y++ P P +D H +F+ + TCG H
Sbjct: 125 RGLRGYFSQG-DQRYFIEPLSPI-HRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQ 182
Query: 186 NKAGMTSLPGGPQSRGR-REARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
N A LP + + R+ + KY+E Y+V D+ F + N + ++R+ E+ANYV
Sbjct: 183 NIA----LPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238
Query: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRP-HDSAQLLTG 303
+ L + L+ VAL G+E+WT++D+ ++T +A+ TL F +WR + ++R HD AQL+T
Sbjct: 239 NMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITA 298
Query: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
G TVGLA + MC + S GV DHS+ + A TMAHE+GH+ G+ HD C
Sbjct: 299 TELAGTTVGLAFMSTMC-SPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSC--- 354
Query: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
S CVM A P FS+CSR FF CL NAP P + +CGN
Sbjct: 355 -KCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQ 413
Query: 424 FVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCD 483
VE GE+CDCG +EC ++CC A C ++ QCA G+CC +C K AG +CR A +CD
Sbjct: 414 LVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECD 473
Query: 484 LPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQ 543
LPE C G S +CP D + ++G PC G G+C G CPTL++QC +LWGPG+ A ++C+
Sbjct: 474 LPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKSCYN 533
Query: 544 VVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQE 603
N G +G C + + +PC D +CGKL CQGG +L + T E
Sbjct: 534 -RNEGGSKYGYC-RRVDDTLIPCKANDTMCGKLFCQGGSDNLPWKGRIVTFLTCKTFDPE 591
Query: 604 VTCRGALALPSAQLDLLGLGLVEPGTQCGP---------------------------RMV 636
T + +G+V GT+CG V
Sbjct: 592 DTSQ-------------EIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAV 638
Query: 637 CNSNHNCHCAPGWAPPFCD 655
C+ C C GW PP CD
Sbjct: 639 CDHELQCQCEEGWIPPDCD 657
>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
[Homo sapiens]
Length = 540
Score = 341 bits (874), Expect = 2e-93
Identities = 187/480 (38%), Positives = 266/480 (55%), Gaps = 23/480 (4%)
Query: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
G+ +L L+KN LLAPGY ET+Y G+ + +P D C+YQG + S + TC
Sbjct: 65 GKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDASISTC 124
Query: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRME-QLLTWKGTCG-------HRDPG 185
G+ G + + Y++ P P +D H +F+ + TCG H
Sbjct: 125 RGLRGYFSQG-DQRYFIEPLSPI-HRDGQEHALFKYNPDEKNYDSTCGMDGVLWAHDLQQ 182
Query: 186 NKAGMTSLPGGPQSRGR-REARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
N A LP + + R+ + KY+E Y+V D+ F + N + ++R+ E+ANYV
Sbjct: 183 NIA----LPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYV 238
Query: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRP-HDSAQLLTG 303
+ L + L+ VAL G+E+WT++D+ ++T +A+ TL F +WR + ++R HD AQL+T
Sbjct: 239 NMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITA 298
Query: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
G TVGLA + MC + S GV DHS+ + A TMAHE+GH+ G+ HD C
Sbjct: 299 TELAGTTVGLAFMSTMC-SPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSC--- 354
Query: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
S CVM A P FS+CSR FF CL NAP P + +CGN
Sbjct: 355 -KCPSTICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQ 413
Query: 424 FVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCD 483
VE GE+CDCG +EC ++CC A C ++ QCA G+CC +C K AG +CR A +CD
Sbjct: 414 LVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKDECD 473
Query: 484 LPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPG--SHPAPEAC 541
LPE C G S +CP D + ++G PC G G+C G CPTL++QC +LWGPG ++P P AC
Sbjct: 474 LPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGRRTNPFPCAC 533
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 328 bits (840), Expect = 2e-89
Identities = 200/622 (32%), Positives = 296/622 (47%), Gaps = 51/622 (8%)
Query: 67 LVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDS 126
L ++ + L+L L ++ L Y ET Y G+ P DHC YQG + DS
Sbjct: 60 LYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDS 119
Query: 127 WVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG--TCGHRDP 184
+ TC+G+ G ++ + Y + P D H +F+ + + +C +
Sbjct: 120 AASISTCNGLRGFFRIN-DQRYLIEPVK---YSDEGEHLVFKYNLRVPYGANYSCTELNF 175
Query: 185 GNKAGMTSLPGGPQSRGRREAR--RTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVAN 242
K ++PG +S + + KY+EL+IVAD T++ N + R+ + N
Sbjct: 176 TRK----TVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVN 231
Query: 243 YVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLL 301
+V+ + +TL+I V L G+E+WT D+ + + TL F W+ L ++ D LL
Sbjct: 232 FVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLL 291
Query: 302 TGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCC 361
+G+ G++ GMC S + D A MAH++GH+LG+ HD C
Sbjct: 292 SGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC- 350
Query: 362 VEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCG 421
SG CVM + P + FS CS+ Q + + C+ N P P CG
Sbjct: 351 ---TCPSGKCVMDSDGSIPALK-FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCG 406
Query: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
N ++ GEECDCGP QEC + CC AH C L+PG CA G+CC C +K AG++CR A +
Sbjct: 407 NKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDE 466
Query: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
CD PE CTG S CP D + ++G PC GYC+ G CPT E QC +L+ + + + C
Sbjct: 467 CDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDIC 526
Query: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDG 601
++ +N+ G+ G C ++ E FLPC +D CGK+ C GG+ S L + D T HL
Sbjct: 527 YK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSL----LGEDKTYHLKD 580
Query: 602 QEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNS-------------------NHN 642
+ D +GLV GT+CG MVCN+ N N
Sbjct: 581 PQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNEN 640
Query: 643 --------CHCAPGWAPPFCDK 656
CHC G AP C++
Sbjct: 641 PVDGHGLQCHCEEGQAPVACEE 662
>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
Length = 769
Score = 325 bits (832), Expect = 1e-88
Identities = 244/700 (34%), Positives = 336/700 (48%), Gaps = 87/700 (12%)
Query: 18 LLLLLWPVPG------AGVLQ-GHIP--GQPVTPHWVLDGQPWRTVS------------- 55
LLL L P PG AG L+ G +P G P P + R S
Sbjct: 12 LLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRV 71
Query: 56 LEEPVSKPDMGLV----ALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT 111
+EP P + L + A L+LE NH LL+ Y+E H+ +G +
Sbjct: 72 RQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGT-TQHSTGAG 130
Query: 112 DHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGS----KDFSTHEIF 167
DHC+YQG++RG P S+ L TC G+ G+ + N +Y + P G + H I+
Sbjct: 131 DHCYYQGKLRGNPHSFAALSTCQGLHGVFS-DGNLTYIVEPQEVAGPWGAPQGPLPHLIY 189
Query: 168 RMEQLLTWKGTCGHRDPG---NKAGMTSLPGGPQSRGRREARRTR-------KYLELYIV 217
R L G R+PG ++ P P+ R +R+ RR KY+EL ++
Sbjct: 190 RTPLL---PDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVI 246
Query: 218 ADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDAN 276
DH LF +++ T V N D + + L+ ++ L +E W + D+ +V D
Sbjct: 247 NDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLL 306
Query: 277 ATLWAFLQWRR-GLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSEL 335
TL + +RR GL P D+ L +GR FQ + G A V G+C GGV+ +
Sbjct: 307 ETLARLMVYRREGL--PEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGN-- 362
Query: 336 PIGA-AATMAHEIGHSLGL------SHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSAC 388
+GA A T+A +G +LG+ S D C + GC+M TG PR FS C
Sbjct: 363 -MGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWL---GCIMED-TGFYLPRKFSRC 417
Query: 389 SRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDL---CCF 445
S + F ++GGG+CL N P L P CGNGFVEAGEECDCG QEC CC
Sbjct: 418 SIDEYNQFLQEGGGSCLFNKPLKLLDPPE--CGNGFVEAGEECDCGSVQECSRAGGNCC- 474
Query: 446 AHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGS 505
C+L A C+ G CC RC +P G CR+A+ +CD+ E CTG SS CPP+++ LDG
Sbjct: 475 -KKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGY 533
Query: 506 PCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLP 565
C G C+ G C T ++QCQ LWG + A C++ +N G G+CG+ G ++
Sbjct: 534 YCDHEQGRCYGGRCKTRDRQCQVLWGHAA--ADRFCYEKLNVEGTERGSCGRKGSG-WVQ 590
Query: 566 CAGRDALCGKLQCQ--GGKPSL--LAPHMVPVDSTVHLDGQEVTCRGALALPSAQL-DLL 620
C+ +D LCG L C G P L L + V T + G+E+ CRG QL D
Sbjct: 591 CSKQDVLCGFLLCVNISGAPRLGDLVGDISSV--TFYHQGKELDCRGG----HVQLADGS 644
Query: 621 GLGLVEPGTQCGPRMVCNSNHNCHCAPGWAPPFCDKPGFG 660
L VE GT CGP M+C + C P A F PG G
Sbjct: 645 DLSYVEDGTACGPNMLCLDH---RCLPASAFNFSTCPGSG 681
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 311 bits (796), Expect = 2e-84
Identities = 232/769 (30%), Positives = 351/769 (45%), Gaps = 112/769 (14%)
Query: 10 GTPLLLLLLLLLLWPVPGAGV---LQGHIPGQP----VTPHWVLDGQPWRTVSLEEPVSK 62
GT + + + LLLLW GV + G+ P +P V+ P + +S
Sbjct: 5 GTLVYIRVTLLLLW----LGVFLSISGYCQAGPSQHFTSPEVVI---PLKVISRGRSAKA 57
Query: 63 PDMGLVALEAEGQELLLELEKNHRLLA---PGYIETHYGPDGQPVVLAPNHTDHCHYQGR 119
P +L GQ+ ++ + L++ P + T + + P D C+Y G
Sbjct: 58 PGWLSYSLRFGGQKHVVHMRVKKLLVSRHLPVFTYTDERALLEDQLFIP---DDCYYHGY 114
Query: 120 VRGFPDSWVVLCTC-SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 178
V G P+S VV C G G++ +S +Y + P R S F H ++++ T
Sbjct: 115 VEGAPESLVVFSACFGGFRGVLKIS-GLTYEIEPI--RHSATFE-HLVYKVNSNET---- 166
Query: 179 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRK-------------YLELYIVADHTLFLT 225
+ P + G+T Q EA + +LEL +V +H F+
Sbjct: 167 ---QFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIY 223
Query: 226 RHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQW 285
N++ ++ + V N VD + + L + L G+E+W + + +T L F QW
Sbjct: 224 SQSNISKVQEDVFLVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMTS-IEQVLNDFSQW 282
Query: 286 RRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAH 345
++ +Q HD+A + + + +GLA V G+CR GV + A T+AH
Sbjct: 283 KQISLSQLQHDAAHMFIKNSLI-SILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAH 341
Query: 346 EIGHSLGLSHDPDGC-CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRK---GG 401
E+GH+LG+ HD + C C E GC+M T F+ CS A F K
Sbjct: 342 ELGHTLGMQHDEEFCFCGER-----GCIMN--TFRVPAEKFTNCSY----ADFMKTTLNQ 390
Query: 402 GACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGD 461
G+CL N P G CGNG VE E+CDCG Q+C C NC+LRPGA CA G
Sbjct: 391 GSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGL 450
Query: 462 CCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPT 521
CC C P+G LCRQ + +CDLPE+C GTS CP D Y+ DG PC+ S YC+ C
Sbjct: 451 CCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCS-DSAYCYQKRCNN 509
Query: 522 LEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGG 581
+Q C++++G + A + C++ +NS G+ G+CG + +L C D CG++QC+
Sbjct: 510 HDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGT-TYLKCHISDVFCGRVQCENV 568
Query: 582 KPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGP-------- 633
+ L + T H++G VTC G ++++ +G V+ GT CGP
Sbjct: 569 RDIPLLQDHFTLQHT-HING--VTCWGIDY--HLRMNISDIGEVKDGTVCGPGKICIHKK 623
Query: 634 ------------------RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDT 675
+ +CN+ H+CHC GW+PP+C G+GGS+DSGP A+
Sbjct: 624 CVSLSVLSHVCLPETCNMKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKR--- 680
Query: 676 FLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD 724
V LPL+ L+ + L CSGPK+
Sbjct: 681 -------GVFLPLIVIPSLSVLTFLFTVGLLMYLR-------QCSGPKE 715
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 309 bits (792), Expect = 6e-84
Identities = 228/758 (30%), Positives = 347/758 (45%), Gaps = 110/758 (14%)
Query: 8 ARGTPLL-LLLLLLLLWPVPGAGVLQGHIPGQP----VTPHWVLDGQPWRTVSLEEPVSK 62
A G PL+ + + LLLLW + GH +P +P V+ P + +S
Sbjct: 52 AVGEPLVHIRVTLLLLWFGMFLSI-SGHSQARPSQYFTSPEVVI---PLKVISRGRGAKA 107
Query: 63 PDMGLVALEAEGQELLLELEKNHRLLAPG-----YIETHYGPDGQPVVLAPNHTDHCHYQ 117
P +L GQ ++ + N L A Y E H QP + D C+Y
Sbjct: 108 PGWLSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFI-----QDDCYYH 162
Query: 118 GRVRGFPDSWVVLCTCSG-MSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWK 176
G V G P+S V L TCSG G++ ++ + Y ++P + + H +++++ T
Sbjct: 163 GYVEGVPESLVALSTCSGGFLGMLQIN-DLVYEIKPISVSATFE---HLVYKIDSDDT-- 216
Query: 177 GTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRK------------YLELYIVADHTLFL 224
+ P + G+T Q + T K ++EL +V D+ +L
Sbjct: 217 -----QFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYL 271
Query: 225 TRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQ 284
N + + V N VD L++ V LTG+++WT + + D + L F
Sbjct: 272 FSQSNATTVQHEVFNVVNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSI 331
Query: 285 WRR-GLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATM 343
W+ L + HD A L + QG +G+A V+G+C+ + GV + A T+
Sbjct: 332 WKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITL 390
Query: 344 AHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRV---FSACSRRQLRAFFRKG 400
HE+GH+LG+ HD C E C+M H + +V FS CS Q
Sbjct: 391 GHELGHNLGMQHDTQWCVCELQ----WCIM-----HAYRKVTTKFSNCSYAQYWDS-TIS 440
Query: 401 GGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAH 459
G C+ P PG CGN VE GEECDCG ++C +D CC NC+L PGA CA
Sbjct: 441 SGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPCCLL-NCTLHPGAACAF 499
Query: 460 GDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGAC 519
G CC C P+G LCRQ +G+CDLPE+C GTS CP DVY+ DG C + +C++ C
Sbjct: 500 GICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTC 558
Query: 520 PTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ 579
+ QC++++G + A ++C+Q +N+ G+ G+CG ++ C D +CG++QC+
Sbjct: 559 NNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGT-TYVKCWTPDIMCGRVQCE 617
Query: 580 GGKPSLLAPHMVPVDSTVHLDGQEVTCRG-----ALALPSAQLDLLGLGLVEPGTQCGP- 633
+ P+++ + + TC G +A+P +G V+ GT CGP
Sbjct: 618 NVG---VIPNLIEHSTVQQFHLNDTTCWGTDYHLGMAIPD-------IGEVKDGTVCGPE 667
Query: 634 -------------------------RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV 668
R +CN+ +CHC WAPP+C G+GGS DSGP
Sbjct: 668 KICIRKKCASMVHLSQACQPKTCNMRGICNNKQHCHCNHEWAPPYCKDKGYGGSADSGPP 727
Query: 669 QAENHDTF-----LLAMLLSVLLPLLPGAGLAWCCYRL 701
N + L + L LLPL+ A L +C + L
Sbjct: 728 PKNNMEGLNVMGKLRYLSLLCLLPLV--AFLLFCLHVL 763
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 307 bits (787), Expect = 2e-83
Identities = 192/600 (32%), Positives = 292/600 (48%), Gaps = 38/600 (6%)
Query: 64 DMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGF 123
D ++A G +L++ NH LL+ YIE H G+ V + +HC+YQG +RG
Sbjct: 87 DQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGN 144
Query: 124 PDSWVVLCTCSGMSGLITLSRNASYYLRPWP-PRGSKDFSTHEIFRMEQL-LTWKGTCGH 181
PDS+V L TC G+ G+ N +Y + P +DF H +++ +
Sbjct: 145 PDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSE 203
Query: 182 RDPGNKAGMTSLPGGPQSRGRREARR-------TRKYLELYIVADHTLFLTRHRNLNHTK 234
N + R +R+ RR KY+EL IV DH +F ++ HT
Sbjct: 204 FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTN 263
Query: 235 QRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQR 293
V N D + + L ++ L +E W ++ ++++ TL F+++RR ++
Sbjct: 264 TYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK 323
Query: 294 PHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVST-DHSELPIGAAATMAHEIGHSLG 352
D+ L +G F+ + G A + G+C GGV+ ++L A T+A + H++G
Sbjct: 324 S-DAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL---MAVTLAQSLAHNIG 379
Query: 353 LSHDP----DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNA 408
+ D G C + GC+M TG+ P+ F+ C+ + F GGGACL N
Sbjct: 380 IISDKRKLASGEC-KCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 409 PDPGLPVPPALCGNGFVEAGEECDCGPGQEC---RDLCCFAHNCSLRPGAQCAHGDCCVR 465
P L P CGNGF+E GEECDCG EC CC C+L +QC+ G CC +
Sbjct: 438 PSKLLDPPE--CGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGLCCKK 493
Query: 466 CLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQ 525
C +P G +CR+A+ DCD+ E C+G SS C P+++ +DG C G C+ G C T ++Q
Sbjct: 494 CKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQ 553
Query: 526 CQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ--GGKP 583
C+ +WG + + C++ +N G GNCG+D + ++ C RD LCG L C G P
Sbjct: 554 CKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGNIP 612
Query: 584 SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNC 643
L + V G+ + C G +D LG VE GT CGP+M+C H C
Sbjct: 613 RLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVD---LGYVEDGTPCGPQMMC-LEHRC 668
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 307 bits (787), Expect = 2e-83
Identities = 192/600 (32%), Positives = 292/600 (48%), Gaps = 38/600 (6%)
Query: 64 DMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGF 123
D ++A G +L++ NH LL+ YIE H G+ V + +HC+YQG +RG
Sbjct: 87 DQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGN 144
Query: 124 PDSWVVLCTCSGMSGLITLSRNASYYLRPWP-PRGSKDFSTHEIFRMEQL-LTWKGTCGH 181
PDS+V L TC G+ G+ N +Y + P +DF H +++ +
Sbjct: 145 PDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSE 203
Query: 182 RDPGNKAGMTSLPGGPQSRGRREARR-------TRKYLELYIVADHTLFLTRHRNLNHTK 234
N + R +R+ RR KY+EL IV DH +F ++ HT
Sbjct: 204 FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTN 263
Query: 235 QRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQR 293
V N D + + L ++ L +E W ++ ++++ TL F+++RR ++
Sbjct: 264 TYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK 323
Query: 294 PHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVST-DHSELPIGAAATMAHEIGHSLG 352
D+ L +G F+ + G A + G+C GGV+ ++L A T+A + H++G
Sbjct: 324 S-DAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL---MAVTLAQSLAHNIG 379
Query: 353 LSHDP----DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNA 408
+ D G C + GC+M TG+ P+ F+ C+ + F GGGACL N
Sbjct: 380 IISDKRKLASGEC-KCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 409 PDPGLPVPPALCGNGFVEAGEECDCGPGQEC---RDLCCFAHNCSLRPGAQCAHGDCCVR 465
P L P CGNGF+E GEECDCG EC CC C+L +QC+ G CC +
Sbjct: 438 PSKLLDPPE--CGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGLCCKK 493
Query: 466 CLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQ 525
C +P G +CR+A+ DCD+ E C+G SS C P+++ +DG C G C+ G C T ++Q
Sbjct: 494 CKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQ 553
Query: 526 CQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ--GGKP 583
C+ +WG + + C++ +N G GNCG+D + ++ C RD LCG L C G P
Sbjct: 554 CKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGNIP 612
Query: 584 SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNC 643
L + V G+ + C G +D LG VE GT CGP+M+C H C
Sbjct: 613 RLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVD---LGYVEDGTPCGPQMMC-LEHRC 668
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 307 bits (787), Expect = 2e-83
Identities = 192/600 (32%), Positives = 292/600 (48%), Gaps = 38/600 (6%)
Query: 64 DMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGF 123
D ++A G +L++ NH LL+ YIE H G+ V + +HC+YQG +RG
Sbjct: 87 DQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGN 144
Query: 124 PDSWVVLCTCSGMSGLITLSRNASYYLRPWP-PRGSKDFSTHEIFRMEQL-LTWKGTCGH 181
PDS+V L TC G+ G+ N +Y + P +DF H +++ +
Sbjct: 145 PDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSE 203
Query: 182 RDPGNKAGMTSLPGGPQSRGRREARR-------TRKYLELYIVADHTLFLTRHRNLNHTK 234
N + R +R+ RR KY+EL IV DH +F ++ HT
Sbjct: 204 FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTN 263
Query: 235 QRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQR 293
V N D + + L ++ L +E W ++ ++++ TL F+++RR ++
Sbjct: 264 TYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK 323
Query: 294 PHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVST-DHSELPIGAAATMAHEIGHSLG 352
D+ L +G F+ + G A + G+C GGV+ ++L A T+A + H++G
Sbjct: 324 S-DAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL---MAVTLAQSLAHNIG 379
Query: 353 LSHDP----DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNA 408
+ D G C + GC+M TG+ P+ F+ C+ + F GGGACL N
Sbjct: 380 IISDKRKLASGEC-KCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 409 PDPGLPVPPALCGNGFVEAGEECDCGPGQEC---RDLCCFAHNCSLRPGAQCAHGDCCVR 465
P L P CGNGF+E GEECDCG EC CC C+L +QC+ G CC +
Sbjct: 438 PSKLLDPPE--CGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGLCCKK 493
Query: 466 CLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQ 525
C +P G +CR+A+ DCD+ E C+G SS C P+++ +DG C G C+ G C T ++Q
Sbjct: 494 CKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQ 553
Query: 526 CQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ--GGKP 583
C+ +WG + + C++ +N G GNCG+D + ++ C RD LCG L C G P
Sbjct: 554 CKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGNIP 612
Query: 584 SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNC 643
L + V G+ + C G +D LG VE GT CGP+M+C H C
Sbjct: 613 RLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVD---LGYVEDGTPCGPQMMC-LEHRC 668
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 307 bits (787), Expect = 2e-83
Identities = 192/600 (32%), Positives = 292/600 (48%), Gaps = 38/600 (6%)
Query: 64 DMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGF 123
D ++A G +L++ NH LL+ YIE H G+ V + +HC+YQG +RG
Sbjct: 87 DQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGN 144
Query: 124 PDSWVVLCTCSGMSGLITLSRNASYYLRPWP-PRGSKDFSTHEIFRMEQL-LTWKGTCGH 181
PDS+V L TC G+ G+ N +Y + P +DF H +++ +
Sbjct: 145 PDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSE 203
Query: 182 RDPGNKAGMTSLPGGPQSRGRREARR-------TRKYLELYIVADHTLFLTRHRNLNHTK 234
N + R +R+ RR KY+EL IV DH +F ++ HT
Sbjct: 204 FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTN 263
Query: 235 QRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQR 293
V N D + + L ++ L +E W ++ ++++ TL F+++RR ++
Sbjct: 264 TYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK 323
Query: 294 PHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVST-DHSELPIGAAATMAHEIGHSLG 352
D+ L +G F+ + G A + G+C GGV+ ++L A T+A + H++G
Sbjct: 324 S-DAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL---MAVTLAQSLAHNIG 379
Query: 353 LSHDP----DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNA 408
+ D G C + GC+M TG+ P+ F+ C+ + F GGGACL N
Sbjct: 380 IISDKRKLASGEC-KCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 409 PDPGLPVPPALCGNGFVEAGEECDCGPGQEC---RDLCCFAHNCSLRPGAQCAHGDCCVR 465
P L P CGNGF+E GEECDCG EC CC C+L +QC+ G CC +
Sbjct: 438 PSKLLDPPE--CGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGLCCKK 493
Query: 466 CLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQ 525
C +P G +CR+A+ DCD+ E C+G SS C P+++ +DG C G C+ G C T ++Q
Sbjct: 494 CKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQ 553
Query: 526 CQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ--GGKP 583
C+ +WG + + C++ +N G GNCG+D + ++ C RD LCG L C G P
Sbjct: 554 CKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGNIP 612
Query: 584 SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNC 643
L + V G+ + C G +D LG VE GT CGP+M+C H C
Sbjct: 613 RLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVD---LGYVEDGTPCGPQMMC-LEHRC 668
>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
[Homo sapiens]
Length = 859
Score = 307 bits (787), Expect = 2e-83
Identities = 192/600 (32%), Positives = 292/600 (48%), Gaps = 38/600 (6%)
Query: 64 DMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGF 123
D ++A G +L++ NH LL+ YIE H G+ V + +HC+YQG +RG
Sbjct: 87 DQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGN 144
Query: 124 PDSWVVLCTCSGMSGLITLSRNASYYLRPWP-PRGSKDFSTHEIFRMEQL-LTWKGTCGH 181
PDS+V L TC G+ G+ N +Y + P +DF H +++ +
Sbjct: 145 PDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSE 203
Query: 182 RDPGNKAGMTSLPGGPQSRGRREARR-------TRKYLELYIVADHTLFLTRHRNLNHTK 234
N + R +R+ RR KY+EL IV DH +F ++ HT
Sbjct: 204 FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTN 263
Query: 235 QRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQR 293
V N D + + L ++ L +E W ++ ++++ TL F+++RR ++
Sbjct: 264 TYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK 323
Query: 294 PHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVST-DHSELPIGAAATMAHEIGHSLG 352
D+ L +G F+ + G A + G+C GGV+ ++L A T+A + H++G
Sbjct: 324 S-DAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL---MAVTLAQSLAHNIG 379
Query: 353 LSHDP----DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNA 408
+ D G C + GC+M TG+ P+ F+ C+ + F GGGACL N
Sbjct: 380 IISDKRKLASGEC-KCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 437
Query: 409 PDPGLPVPPALCGNGFVEAGEECDCGPGQEC---RDLCCFAHNCSLRPGAQCAHGDCCVR 465
P L P CGNGF+E GEECDCG EC CC C+L +QC+ G CC +
Sbjct: 438 PSKLLDPPE--CGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGLCCKK 493
Query: 466 CLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQ 525
C +P G +CR+A+ DCD+ E C+G SS C P+++ +DG C G C+ G C T ++Q
Sbjct: 494 CKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQ 553
Query: 526 CQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ--GGKP 583
C+ +WG + + C++ +N G GNCG+D + ++ C RD LCG L C G P
Sbjct: 554 CKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGNIP 612
Query: 584 SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNC 643
L + V G+ + C G +D LG VE GT CGP+M+C H C
Sbjct: 613 RLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVD---LGYVEDGTPCGPQMMC-LEHRC 668
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 296 bits (759), Expect = 4e-80
Identities = 193/591 (32%), Positives = 297/591 (50%), Gaps = 48/591 (8%)
Query: 70 LEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVV 129
+EA G + +L+L N+ LL+ Y+E HY +G+P +HC+Y G +RG DS V
Sbjct: 155 IEAFGSKFILDLILNNGLLSSDYVEIHY-ENGKPQYSKGG--EHCYYHGSIRGVKDSKVA 211
Query: 130 LCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAG 189
L TC+G+ G+ Y + P + ST +++ L + + ++ + G
Sbjct: 212 LSTCNGLHGMFE-DDTFVYMIEPLELVHDEK-STGRPHIIQKTLAGQYSKQMKNLTMERG 269
Query: 190 -----MTSLPGGPQSRGRREARRTR------KYLELYIVADHTLFLTRHRNLNHTKQRLL 238
++ L R +R +R KYLEL IV DH + + HT
Sbjct: 270 DQWPFLSELQW--LKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAK 327
Query: 239 EVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDS 297
V N VD + + L+ +V L +E WTE+D+ +T + L F ++R+ + ++ D+
Sbjct: 328 SVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI--KQHADA 385
Query: 298 AQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP 357
L++ F L+ G+C + GV + LP+ A ++ + +LG+ +P
Sbjct: 386 VHLISRVTFHYKRSSLSYFGGVC--SRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEP 443
Query: 358 DG----C-CVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPG 412
C C E+ GGC+M TG R FS CS + R F ++GGGACL N P
Sbjct: 444 SSRKPKCDCTESW---GGCIMEE-TGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKL 499
Query: 413 LPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCC--VRCLLKP 470
P CGNG+VEAGEECDCG EC LCC CSL GA C+ G CC CL +P
Sbjct: 500 FE--PTECGNGYVEAGEECDCGFHVECYGLCC--KKCSLSNGAHCSDGPCCNNTSCLFQP 555
Query: 471 AGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLW 530
G CR A+ +CD+ E+CTG S CPP+++ DG C + G C++G C T + QCQ +W
Sbjct: 556 RGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIW 615
Query: 531 GPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQC----QGGKPSLL 586
G + + + C++ +N+ G GNCG+D + ++ C+ D CG L C + + L
Sbjct: 616 GTKAAGSDKFCYEKLNTEGTEKGNCGKDGD-RWIQCSKHDVFCGFLLCTNLTRAPRIGQL 674
Query: 587 APHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVC 637
++P ++ + G+ + C GA + D +G VE GT CGP M+C
Sbjct: 675 QGEIIP--TSFYHQGRVIDCSGAHVVLDDDTD---VGYVEDGTPCGPSMMC 720
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 292 bits (747), Expect = 9e-79
Identities = 204/633 (32%), Positives = 303/633 (47%), Gaps = 59/633 (9%)
Query: 70 LEAEGQELLLELEKNHRLLAPGYIETH-YGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWV 128
L+ +G++ +L L RLL P ++ + G+ + P C+Y G V+ DS
Sbjct: 66 LQLKGKKHVLHLWPK-RLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKA 124
Query: 129 VLCTC-SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNK 187
+ TC G+ G+ + +A +Y + P + S F H ++ +++ CG D +
Sbjct: 125 TISTCMGGLRGVFNI--DAKHY-QIEPLKASPSFE-HVVYLLKKEQFGNQVCGLSDDEIE 180
Query: 188 AGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQL 247
M + R + + KYLEL ++ D + + + NL+ + + +D
Sbjct: 181 WQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTY 240
Query: 248 LRTLDIQVALTGLEVWTERDRSRVTQDANA-TLWAFLQWRRG-LWAQRPHDSAQLLTGRA 305
+ + +++ L LEVWT+ ++ RV A L F+ +++ L A+ D A L R
Sbjct: 241 FQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRK 300
Query: 306 FQGATVGLAPVEG-MCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEA 364
+ A LA G +C E +G VST + A AHE+GH++G+SHD C
Sbjct: 301 YNDA---LAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRG 357
Query: 365 AAESGGCVMAAA-TGHPFPRVFSACSRRQLRAFFR--KGGGACLSNAPDPGLPVPPALCG 421
C+M + TG FS CS +FF+ G CL+N P GL CG
Sbjct: 358 RLN---CIMGSGRTG------FSNCS---YISFFKHISSGATCLNNIP--GLGYVLKRCG 403
Query: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
N VE EECDCG +EC+ C NC L+PGA C+ G CC C +P+G +CRQ +
Sbjct: 404 NKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNE 463
Query: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
CDL E+C G SS CP DVY DG+PC + G C+ C + QCQ ++GP + AP C
Sbjct: 464 CDLAEYCDGNSSSCPNDVYKQDGTPC-KYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSEC 522
Query: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDG 601
+ VN GD GNC +F C +++CG+LQC + P + ST HL
Sbjct: 523 YDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIIST-HLQA 581
Query: 602 QEVTCRG-ALALPSAQLDLLGLGLVEPGTQCG--------------------------PR 634
+ + C G L + + LG++ GT CG R
Sbjct: 582 ENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTR 641
Query: 635 MVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGP 667
VCN+ NCHC GWAPPFC++ G+GGS+DSGP
Sbjct: 642 GVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGP 674
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 288 bits (737), Expect = 1e-77
Identities = 230/825 (27%), Positives = 369/825 (44%), Gaps = 104/825 (12%)
Query: 14 LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73
+LLLL L + +G +Q P P V+ P R ++ P L
Sbjct: 3 MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59
Query: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
GQ+ ++ ++ L + Y G + P ++C+Y G V G P+S V L TC
Sbjct: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
Query: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185
G G++ ++ + +Y ++P FST H +++M+ Q T + +
Sbjct: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172
Query: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
+ + Q + + +E+ +V D+ L++ RN + + L + N V
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
Query: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303
D +L + ++V L GLE+WT ++ V D ++ + +W+ + + HD++ L T
Sbjct: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
Query: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
+G + G+ GMC S + T ++ + +AH +GH+LG++HD D C
Sbjct: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347
Query: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
C+M G+P FS CS + + L + CGNG
Sbjct: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403
Query: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482
VE GEECDCGP + C +D CC + NC+L G+ CA G CC C P+G +CR+ + +C
Sbjct: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462
Query: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542
DLPE+C GTS CP D Y+ DG PC + GYC++ +C +QC++++G G++ A E C+
Sbjct: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521
Query: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601
+ +N+ GD G+CG ++ C D CG++QC+ P+M +TVH
Sbjct: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576
Query: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCG--------------------------P 633
++ C L + G +G V+ GT+CG
Sbjct: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632
Query: 634 RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 690
R +CN+ H+CHC W PP C G+GGS+DSGP + + +L +LL VL LL
Sbjct: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691
Query: 691 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 747
C YRL C++ +D ++ P EL P + Q
Sbjct: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733
Query: 748 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784
PW P+ P SH P P + P V+P +V +S
Sbjct: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 288 bits (737), Expect = 1e-77
Identities = 230/825 (27%), Positives = 369/825 (44%), Gaps = 104/825 (12%)
Query: 14 LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73
+LLLL L + +G +Q P P V+ P R ++ P L
Sbjct: 3 MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59
Query: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
GQ+ ++ ++ L + Y G + P ++C+Y G V G P+S V L TC
Sbjct: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
Query: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185
G G++ ++ + +Y ++P FST H +++M+ Q T + +
Sbjct: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172
Query: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
+ + Q + + +E+ +V D+ L++ RN + + L + N V
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
Query: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303
D +L + ++V L GLE+WT ++ V D ++ + +W+ + + HD++ L T
Sbjct: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
Query: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
+G + G+ GMC S + T ++ + +AH +GH+LG++HD D C
Sbjct: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347
Query: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
C+M G+P FS CS + + L + CGNG
Sbjct: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403
Query: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482
VE GEECDCGP + C +D CC + NC+L G+ CA G CC C P+G +CR+ + +C
Sbjct: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462
Query: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542
DLPE+C GTS CP D Y+ DG PC + GYC++ +C +QC++++G G++ A E C+
Sbjct: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521
Query: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601
+ +N+ GD G+CG ++ C D CG++QC+ P+M +TVH
Sbjct: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576
Query: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCG--------------------------P 633
++ C L + G +G V+ GT+CG
Sbjct: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632
Query: 634 RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 690
R +CN+ H+CHC W PP C G+GGS+DSGP + + +L +LL VL LL
Sbjct: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691
Query: 691 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 747
C YRL C++ +D ++ P EL P + Q
Sbjct: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733
Query: 748 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784
PW P+ P SH P P + P V+P +V +S
Sbjct: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 288 bits (737), Expect = 1e-77
Identities = 230/825 (27%), Positives = 369/825 (44%), Gaps = 104/825 (12%)
Query: 14 LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73
+LLLL L + +G +Q P P V+ P R ++ P L
Sbjct: 3 MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59
Query: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
GQ+ ++ ++ L + Y G + P ++C+Y G V G P+S V L TC
Sbjct: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
Query: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185
G G++ ++ + +Y ++P FST H +++M+ Q T + +
Sbjct: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172
Query: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
+ + Q + + +E+ +V D+ L++ RN + + L + N V
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
Query: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303
D +L + ++V L GLE+WT ++ V D ++ + +W+ + + HD++ L T
Sbjct: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
Query: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
+G + G+ GMC S + T ++ + +AH +GH+LG++HD D C
Sbjct: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347
Query: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
C+M G+P FS CS + + L + CGNG
Sbjct: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403
Query: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482
VE GEECDCGP + C +D CC + NC+L G+ CA G CC C P+G +CR+ + +C
Sbjct: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462
Query: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542
DLPE+C GTS CP D Y+ DG PC + GYC++ +C +QC++++G G++ A E C+
Sbjct: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521
Query: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601
+ +N+ GD G+CG ++ C D CG++QC+ P+M +TVH
Sbjct: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576
Query: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCG--------------------------P 633
++ C L + G +G V+ GT+CG
Sbjct: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632
Query: 634 RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 690
R +CN+ H+CHC W PP C G+GGS+DSGP + + +L +LL VL LL
Sbjct: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691
Query: 691 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 747
C YRL C++ +D ++ P EL P + Q
Sbjct: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733
Query: 748 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784
PW P+ P SH P P + P V+P +V +S
Sbjct: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 288 bits (737), Expect = 1e-77
Identities = 230/825 (27%), Positives = 369/825 (44%), Gaps = 104/825 (12%)
Query: 14 LLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAE 73
+LLLL L + +G +Q P P V+ P R ++ P L
Sbjct: 3 MLLLLHCLGVFLSCSGHIQDEHPQYHSPPDVVI---PVRITGTTRGMTPPGWLSYILPFG 59
Query: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
GQ+ ++ ++ L + Y G + P ++C+Y G V G P+S V L TC
Sbjct: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
Query: 134 -SGMSGLITLSRNASYYLRPWPPRGSKDFST---HEIFRME----QLLTWKGTCGHRDPG 185
G G++ ++ + +Y ++P FST H +++M+ Q T + +
Sbjct: 120 FGGFQGILQIN-DFAYEIKPLA------FSTTFEHLVYKMDSEEKQFSTMRSGFMQNEIT 172
Query: 186 NKAGMTSLPGGPQSRGRREARRTR-KYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
+ + Q + + +E+ +V D+ L++ RN + + L + N V
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
Query: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWR-RGLWAQRPHDSAQLLTG 303
D +L + ++V L GLE+WT ++ V D ++ + +W+ + + HD++ L T
Sbjct: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
Query: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVE 363
+G + G+ GMC S + T ++ + +AH +GH+LG++HD D C
Sbjct: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC--- 347
Query: 364 AAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNG 423
C+M G+P FS CS + + L + CGNG
Sbjct: 348 -RCSQPRCIMHE--GNPPITKFSNCSYGDFWEYTVERTKCLLETVHTKDI-FNVKRCGNG 403
Query: 424 FVEAGEECDCGPGQEC-RDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDC 482
VE GEECDCGP + C +D CC + NC+L G+ CA G CC C P+G +CR+ + +C
Sbjct: 404 VVEEGEECDCGPLKHCAKDPCCLS-NCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNEC 462
Query: 483 DLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACF 542
DLPE+C GTS CP D Y+ DG PC + GYC++ +C +QC++++G G++ A E C+
Sbjct: 463 DLPEWCNGTSHKCPDDFYVEDGIPC-KERGYCYEKSCHDRNEQCRRIFGAGANTASETCY 521
Query: 543 QVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH-LDG 601
+ +N+ GD G+CG ++ C D CG++QC+ P+M +TVH
Sbjct: 522 KELNTLGDRVGHCG-IKNATYIKCNISDVQCGRIQCENVTE---IPNMSD-HTTVHWARF 576
Query: 602 QEVTCRGALALPSAQLDLLG--LGLVEPGTQCG--------------------------P 633
++ C L + G +G V+ GT+CG
Sbjct: 577 NDIMCWST----DYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHITILNSNCSPAFCNK 632
Query: 634 RMVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV---QAENHDTFLLAMLLSVLLPLLP 690
R +CN+ H+CHC W PP C G+GGS+DSGP + + +L +LL VL LL
Sbjct: 633 RGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVLFILL- 691
Query: 691 GAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKD---GPHRDHPLGGVHPMELGPTATGQ 747
C YRL C++ +D ++ P EL P + Q
Sbjct: 692 -----CCLYRL-----------CKKSKPIKKQQDVQTPSAKEEEKIQRRPHELPPQS--Q 733
Query: 748 PW--------PLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRS 784
PW P+ P SH P P + P V+P +V +S
Sbjct: 734 PWVMPSQSQPPVTPSQSH-PQVMPSQSQPPVTPSQSQPRVMPSQS 777
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.474
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,168,556
Number of Sequences: 37866
Number of extensions: 2353151
Number of successful extensions: 8507
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 159
Number of HSP's that attempted gapping in prelim test: 7444
Number of HSP's gapped (non-prelim): 870
length of query: 787
length of database: 18,247,518
effective HSP length: 110
effective length of query: 677
effective length of database: 14,082,258
effective search space: 9533688666
effective search space used: 9533688666
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.