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Search of human proteins with 223671932
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
(391 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens] 811 0.0
gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens] 811 0.0
gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens] 811 0.0
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot... 353 1e-97
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 353 1e-97
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 270 2e-72
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 249 4e-66
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 230 2e-60
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 230 2e-60
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 223 2e-58
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 214 8e-56
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 211 9e-55
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 211 9e-55
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 192 3e-49
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 192 3e-49
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 192 3e-49
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 192 3e-49
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 192 3e-49
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 192 3e-49
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 162 5e-40
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 152 7e-37
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 149 4e-36
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 148 9e-36
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 143 2e-34
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 143 2e-34
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 143 2e-34
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 143 2e-34
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 135 8e-32
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 134 2e-31
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 134 2e-31
>gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens]
Length = 470
Score = 811 bits (2095), Expect = 0.0
Identities = 391/391 (100%), Positives = 391/391 (100%)
Query: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS
Sbjct: 80 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 139
Query: 61 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 120
ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI
Sbjct: 140 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 199
Query: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI
Sbjct: 200 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 259
Query: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 240
DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV
Sbjct: 260 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 319
Query: 241 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY
Sbjct: 320 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 379
Query: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP
Sbjct: 380 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 439
Query: 361 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 391
KECTNLCCEALTCKLKPGTDCGGDAPNHTTE
Sbjct: 440 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 470
>gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
Length = 391
Score = 811 bits (2095), Expect = 0.0
Identities = 391/391 (100%), Positives = 391/391 (100%)
Query: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS
Sbjct: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
Query: 61 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 120
ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI
Sbjct: 61 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 120
Query: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI
Sbjct: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
Query: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 240
DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV
Sbjct: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 240
Query: 241 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY
Sbjct: 241 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
Query: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP
Sbjct: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
Query: 361 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 391
KECTNLCCEALTCKLKPGTDCGGDAPNHTTE
Sbjct: 361 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 391
>gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
Length = 391
Score = 811 bits (2095), Expect = 0.0
Identities = 391/391 (100%), Positives = 391/391 (100%)
Query: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS
Sbjct: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
Query: 61 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 120
ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI
Sbjct: 61 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 120
Query: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI
Sbjct: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
Query: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 240
DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV
Sbjct: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 240
Query: 241 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY
Sbjct: 241 GLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
Query: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP
Sbjct: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
Query: 361 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 391
KECTNLCCEALTCKLKPGTDCGGDAPNHTTE
Sbjct: 361 KECTNLCCEALTCKLKPGTDCGGDAPNHTTE 391
>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
[Homo sapiens]
Length = 540
Score = 353 bits (907), Expect = 1e-97
Identities = 179/388 (46%), Positives = 251/388 (64%), Gaps = 8/388 (2%)
Query: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
M +NG+ +L L+K K+LL P YTET Y+ G+EITT P+ M+ CYY+G+ILNEK S AS
Sbjct: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
Query: 61 ISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST----D 114
ISTC GLRGYF+ QRY I+PL D +EHA+F N +E++ + TCG+ D
Sbjct: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWAHD 179
Query: 115 GKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLN 174
+Q + L + +KYI+ YLVLDN +K YNEN IR VF++ N +N
Sbjct: 180 LQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVN 239
Query: 175 VIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLSGI 233
++Y ++ VALVGMEIW+D DKIK+ P+AS T +NF +W S L + K HD AQL++
Sbjct: 240 MLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITAT 299
Query: 234 SFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSG 293
VGLA +++CSP SV V++ N + + G M+HE+GH GM ++ KCPS
Sbjct: 300 ELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPST 359
Query: 294 SCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGE 353
CVM++ LS P DFS+ R ++++ + CL AP+PT+I++TP+CGN L+E+GE
Sbjct: 360 ICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGE 419
Query: 354 DCDCGSPKECTNLCCEALTCKLKPGTDC 381
DCDCG+ +ECTN+CC+A TCK+K C
Sbjct: 420 DCDCGTSEECTNICCDAKTCKIKATFQC 447
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 353 bits (907), Expect = 1e-97
Identities = 179/388 (46%), Positives = 251/388 (64%), Gaps = 8/388 (2%)
Query: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
M +NG+ +L L+K K+LL P YTET Y+ G+EITT P+ M+ CYY+G+ILNEK S AS
Sbjct: 61 MTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVSDAS 120
Query: 61 ISTCDGLRGYFTHHHQRYQIKPLKST--DEKEHAVFTSNQEEQDPANHTCGVKST----D 114
ISTC GLRGYF+ QRY I+PL D +EHA+F N +E++ + TCG+ D
Sbjct: 121 ISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYNPDEKN-YDSTCGMDGVLWAHD 179
Query: 115 GKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLN 174
+Q + L + +KYI+ YLVLDN +K YNEN IR VF++ N +N
Sbjct: 180 LQQNIALPATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVN 239
Query: 175 VIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGK-KIHDHAQLLSGI 233
++Y ++ VALVGMEIW+D DKIK+ P+AS T +NF +W S L + K HD AQL++
Sbjct: 240 MLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITAT 299
Query: 234 SFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSG 293
VGLA +++CSP SV V++ N + + G M+HE+GH GM ++ KCPS
Sbjct: 300 ELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPST 359
Query: 294 SCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGE 353
CVM++ LS P DFS+ R ++++ + CL AP+PT+I++TP+CGN L+E+GE
Sbjct: 360 ICVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGE 419
Query: 354 DCDCGSPKECTNLCCEALTCKLKPGTDC 381
DCDCG+ +ECTN+CC+A TCK+K C
Sbjct: 420 DCDCGTSEECTNICCDAKTCKIKATFQC 447
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 270 bits (690), Expect = 2e-72
Identities = 145/381 (38%), Positives = 217/381 (56%), Gaps = 5/381 (1%)
Query: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
LN + ++L L +++ LG +Y+ET YS +GE T P+ M+HC+Y+G+I++E +S ASIS
Sbjct: 65 LNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASIS 124
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRI 122
TC+GLRG+F + QRY I+P+K +DE EH VF N AN++C + K P
Sbjct: 125 TCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVP--G 182
Query: 123 SRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDV 182
+ K + +KY++L++V D+ Y+ +R+ ++ ++N +N+IY T+++
Sbjct: 183 DNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNI 242
Query: 183 QVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNL-GKKIHDHAQLLSGISFNNRRVG 241
V LVG+EIW+ DKI++ + TT F W L +K DH LLSG + G
Sbjct: 243 HVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQG 302
Query: 242 LAASNSLCSP-SSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
++ +C P S ++I+ + + M+H+LGH LGM F CPSG CVM+
Sbjct: 303 ISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSD 362
Query: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
S K FS + + +YL KP C+L P P N CGN L+ GE+CDCG
Sbjct: 363 GSIPALK-FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPA 421
Query: 361 KECTNLCCEALTCKLKPGTDC 381
+ECTN CC+A TC LKPG C
Sbjct: 422 QECTNPCCDAHTCVLKPGFTC 442
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 249 bits (635), Expect = 4e-66
Identities = 140/389 (35%), Positives = 212/389 (54%), Gaps = 17/389 (4%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G L L+K + LLG YTET + G E+T +P +HC+Y+G++ +S AS+STC
Sbjct: 65 GHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTC 124
Query: 65 DGLRGYFTHHHQRYQIKPLKSTDEK-EHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRIS 123
GLRG+F + I+PL E HAV+ + Q TCGV +D G +
Sbjct: 125 AGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAG--TCGV--SDDSLGSLLGP 180
Query: 124 RSLK--SPEKEDFL--RAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNT 179
R+ P D L R +Y++LY+V+DNA ++ +R V +V+N ++ +Y
Sbjct: 181 RTAAVFRPRPGDSLPSRETRYVELYVVVDNAEFQMLGSEAA-VRHRVLEVVNHVDKLYQK 239
Query: 180 IDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKK-IHDHAQLLSGISFNNR 238
++ +V LVG+EIW+ D+ V P S T +N L W + ++ +HD+ QL++G+ F
Sbjct: 240 LNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGT 299
Query: 239 RVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKC------PS 292
VG A +++CS SS AV + KN V + M+HE+GH LGM C +
Sbjct: 300 TVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEA 359
Query: 293 GSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVG 352
G C+M + S FP+ FS +A+ E +L + CL AP ++++ PVCGN +E G
Sbjct: 360 GRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERG 419
Query: 353 EDCDCGSPKECTNLCCEALTCKLKPGTDC 381
E CDCG P++C N CC + TC+L G C
Sbjct: 420 EQCDCGPPEDCRNRCCNSTTCQLAEGAQC 448
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 230 bits (586), Expect = 2e-60
Identities = 125/386 (32%), Positives = 192/386 (49%), Gaps = 11/386 (2%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G+E++L L+K LL P Y ET Y P G+ + P + +HC+Y+G + +S + TC
Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
Query: 65 DGLRGYFT-HHHQRYQIKPLK---STDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 120
G+ G T + Y ++P S D H +F E+ TCG + K G
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF--RMEQLLTWKGTCGHRDPGNKAGMT 191
Query: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
+ +S + + R +KY++LY+V D+ + + NL + + +V N ++ + T+
Sbjct: 192 SLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTL 251
Query: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 240
D+QVAL G+E+W++ D+ +V A+ T FL+W ++ HD AQLL+G +F V
Sbjct: 252 DIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATV 311
Query: 241 GLAASNSLC-SPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVP----FNTKCPSGSC 295
GLA +C + SS V + + M+HE+GH LG+ P SG C
Sbjct: 312 GLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGC 371
Query: 296 VMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDC 355
VM FP+ FS R + CL AP P + +CGN +E GE+C
Sbjct: 372 VMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEEC 431
Query: 356 DCGSPKECTNLCCEALTCKLKPGTDC 381
DCG +EC +LCC A C L+PG C
Sbjct: 432 DCGPGQECRDLCCFAHNCSLRPGAQC 457
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 230 bits (586), Expect = 2e-60
Identities = 125/386 (32%), Positives = 192/386 (49%), Gaps = 11/386 (2%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G+E++L L+K LL P Y ET Y P G+ + P + +HC+Y+G + +S + TC
Sbjct: 74 GQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTC 133
Query: 65 DGLRGYFT-HHHQRYQIKPLK---STDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPI 120
G+ G T + Y ++P S D H +F E+ TCG + K G
Sbjct: 134 SGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF--RMEQLLTWKGTCGHRDPGNKAGMT 191
Query: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
+ +S + + R +KY++LY+V D+ + + NL + + +V N ++ + T+
Sbjct: 192 SLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTL 251
Query: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRV 240
D+QVAL G+E+W++ D+ +V A+ T FL+W ++ HD AQLL+G +F V
Sbjct: 252 DIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATV 311
Query: 241 GLAASNSLC-SPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVP----FNTKCPSGSC 295
GLA +C + SS V + + M+HE+GH LG+ P SG C
Sbjct: 312 GLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGC 371
Query: 296 VMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDC 355
VM FP+ FS R + CL AP P + +CGN +E GE+C
Sbjct: 372 VMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEEC 431
Query: 356 DCGSPKECTNLCCEALTCKLKPGTDC 381
DCG +EC +LCC A C L+PG C
Sbjct: 432 DCGPGQECRDLCCFAHNCSLRPGAQC 457
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 223 bits (568), Expect = 2e-58
Identities = 127/391 (32%), Positives = 201/391 (51%), Gaps = 13/391 (3%)
Query: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
++ G E+IL L+K + L P YTET Y+ G TT + +HC+Y G + + S +
Sbjct: 69 VMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVT 128
Query: 61 ISTCDGLRGYFT-HHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KSTDGK 116
+STC G+RG T + Y I+PL + + +H ++ S + P N CG K T
Sbjct: 129 LSTCRGIRGLITVSSNLSYVIEPLPDS-KGQHLIYRSEHLKPPPGN--CGFEHSKPTTRD 185
Query: 117 QGPIRISRSLKSPE--KEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLN 174
++ K P K + L + KY++LYLV D ++ + + + ++ N ++
Sbjct: 186 WALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVD 245
Query: 175 VIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGIS 234
Y ++++++ALVG+E+W+ G+ +V + +T +FL W L +K HD+AQL++G+S
Sbjct: 246 KFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMS 305
Query: 235 FNNRRVGLAASNSLCSP-SSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVP---FNTKC 290
F+ +GLA ++CS S V +N + + M+HE+GH GM +
Sbjct: 306 FHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASA 365
Query: 291 PSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLE 350
G C+M FPK F+ R +RYL S CL P + CGN LE
Sbjct: 366 ADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLE 425
Query: 351 VGEDCDCGSPKECTNLCCEALTCKLKPGTDC 381
GE+CDCG +EC N CC A C L+PG +C
Sbjct: 426 DGEECDCGEEEECNNPCCNASNCTLRPGAEC 456
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 214 bits (546), Expect = 8e-56
Identities = 126/388 (32%), Positives = 202/388 (52%), Gaps = 17/388 (4%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G+E I+ L++ K LL D+ Y+ G IT P HC+Y+G + NS ++S C
Sbjct: 74 GKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDC 133
Query: 65 DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISR 124
GLRG + Y I+PL+++ EH ++ + ++P CGV + D ++ +
Sbjct: 134 FGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLK--CGVSNKDIEKETAK-DE 190
Query: 125 SLKSPEKEDFLRAQ-------KYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIY 177
+ P LR + +Y++L++V+D Y N T +R + + N L+ +Y
Sbjct: 191 EEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMY 250
Query: 178 NTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNL-GKKIHDHAQLLSGISFN 236
+++++ LVG+EIW++G+ I +V A NF++W L ++ HD AQL+ F
Sbjct: 251 IMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLKKGFG 310
Query: 237 NRRVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGM-PDVPFNTKCPSGS 294
G+A ++CS S I + V +++HELGH LGM D + C + S
Sbjct: 311 G-TAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSCGAKS 369
Query: 295 CVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGED 354
C+MN S ++FS+ FE+ L++ CLL P P + P CGN L++ GE+
Sbjct: 370 CIMNSGASGS--RNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEE 427
Query: 355 CDCGSPKEC-TNLCCEALTCKLKPGTDC 381
CDCG+PKEC + CCE TCKLK +C
Sbjct: 428 CDCGTPKECELDPCCEGSTCKLKSFAEC 455
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 211 bits (537), Expect = 9e-55
Identities = 120/397 (30%), Positives = 195/397 (49%), Gaps = 30/397 (7%)
Query: 6 EEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPEN---MEHCYYKGNILNEKNSVASIS 62
+E+I++L++ + L+ +TET Y G +++ + HCYY G++ +S S+S
Sbjct: 77 KELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLS 136
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQG--PI 120
TC GLRG ++ Y ++P+KS +N+ + PA V+ + G P
Sbjct: 137 TCSGLRGLIVFENESYVLEPMKSA---------TNRYKLFPAKKLKSVRGSCGSHHNTPN 187
Query: 121 RISRSLKSP--------EKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNL 172
++++ P K + L+A KY++L +V DN ++ ++L ++ + ++ N
Sbjct: 188 LAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANH 247
Query: 173 LNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNL-GKKIHDHAQLLS 231
++ Y +++++ LVG+E+W+D DK V T+ FL W L +K HD+AQL+S
Sbjct: 248 VDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVS 307
Query: 232 GISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKC 290
G+ F +G+A S+C+ S ++ N + ++HELGH GM + C
Sbjct: 308 GVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGC 367
Query: 291 P------SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVC 344
G C+MN FP FS+ R E L CL P C
Sbjct: 368 SCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKC 427
Query: 345 GNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 381
GN +E GE+CDCG P+EC N CC A TC LKP C
Sbjct: 428 GNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVC 464
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 211 bits (537), Expect = 9e-55
Identities = 120/397 (30%), Positives = 195/397 (49%), Gaps = 30/397 (7%)
Query: 6 EEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPEN---MEHCYYKGNILNEKNSVASIS 62
+E+I++L++ + L+ +TET Y G +++ + HCYY G++ +S S+S
Sbjct: 77 KELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLS 136
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQG--PI 120
TC GLRG ++ Y ++P+KS +N+ + PA V+ + G P
Sbjct: 137 TCSGLRGLIVFENESYVLEPMKSA---------TNRYKLFPAKKLKSVRGSCGSHHNTPN 187
Query: 121 RISRSLKSP--------EKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNL 172
++++ P K + L+A KY++L +V DN ++ ++L ++ + ++ N
Sbjct: 188 LAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANH 247
Query: 173 LNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNL-GKKIHDHAQLLS 231
++ Y +++++ LVG+E+W+D DK V T+ FL W L +K HD+AQL+S
Sbjct: 248 VDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVS 307
Query: 232 GISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKC 290
G+ F +G+A S+C+ S ++ N + ++HELGH GM + C
Sbjct: 308 GVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGC 367
Query: 291 P------SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVC 344
G C+MN FP FS+ R E L CL P C
Sbjct: 368 SCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKC 427
Query: 345 GNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 381
GN +E GE+CDCG P+EC N CC A TC LKP C
Sbjct: 428 GNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVC 464
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 192 bits (489), Expect = 3e-49
Identities = 118/395 (29%), Positives = 196/395 (49%), Gaps = 14/395 (3%)
Query: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G + S SI
Sbjct: 75 LDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSIC 134
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KSTDGKQGP 119
TC GLRG +R D + + + Q+ P HTC + +S ++ P
Sbjct: 135 TCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESVHTQKPP 193
Query: 120 IRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNT 179
+ D + K ++L +V D++ + Y + L+ +V LL+ +
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLLDTFFRP 252
Query: 180 IDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSGISFNNR 238
++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G SF+
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 239 RVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-----KCP 291
VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+ P
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
+ +C+M +FS R E+ LL CL + +P+ CGN +E
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCGNMFVEP 431
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 386
GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 192 bits (489), Expect = 3e-49
Identities = 118/395 (29%), Positives = 196/395 (49%), Gaps = 14/395 (3%)
Query: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G + S SI
Sbjct: 75 LDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSIC 134
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KSTDGKQGP 119
TC GLRG +R D + + + Q+ P HTC + +S ++ P
Sbjct: 135 TCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESVHTQKPP 193
Query: 120 IRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNT 179
+ D + K ++L +V D++ + Y + L+ +V LL+ +
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLLDTFFRP 252
Query: 180 IDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSGISFNNR 238
++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G SF+
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 239 RVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-----KCP 291
VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+ P
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
+ +C+M +FS R E+ LL CL + +P+ CGN +E
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCGNMFVEP 431
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 386
GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 192 bits (489), Expect = 3e-49
Identities = 118/395 (29%), Positives = 196/395 (49%), Gaps = 14/395 (3%)
Query: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G + S SI
Sbjct: 75 LDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSIC 134
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KSTDGKQGP 119
TC GLRG +R D + + + Q+ P HTC + +S ++ P
Sbjct: 135 TCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESVHTQKPP 193
Query: 120 IRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNT 179
+ D + K ++L +V D++ + Y + L+ +V LL+ +
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLLDTFFRP 252
Query: 180 IDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSGISFNNR 238
++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G SF+
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 239 RVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-----KCP 291
VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+ P
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
+ +C+M +FS R E+ LL CL + +P+ CGN +E
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCGNMFVEP 431
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 386
GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 192 bits (489), Expect = 3e-49
Identities = 118/395 (29%), Positives = 196/395 (49%), Gaps = 14/395 (3%)
Query: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G + S SI
Sbjct: 75 LDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSIC 134
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KSTDGKQGP 119
TC GLRG +R D + + + Q+ P HTC + +S ++ P
Sbjct: 135 TCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESVHTQKPP 193
Query: 120 IRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNT 179
+ D + K ++L +V D++ + Y + L+ +V LL+ +
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLLDTFFRP 252
Query: 180 IDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSGISFNNR 238
++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G SF+
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 239 RVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-----KCP 291
VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+ P
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
+ +C+M +FS R E+ LL CL + +P+ CGN +E
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCGNMFVEP 431
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 386
GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 192 bits (489), Expect = 3e-49
Identities = 118/395 (29%), Positives = 196/395 (49%), Gaps = 14/395 (3%)
Query: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G + S SI
Sbjct: 75 LDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSIC 134
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KSTDGKQGP 119
TC GLRG +R D + + + Q+ P HTC + +S ++ P
Sbjct: 135 TCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESVHTQKPP 193
Query: 120 IRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNT 179
+ D + K ++L +V D++ + Y + L+ +V LL+ +
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLLDTFFRP 252
Query: 180 IDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSGISFNNR 238
++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G SF+
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 239 RVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-----KCP 291
VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+ P
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
+ +C+M +FS R E+ LL CL + +P+ CGN +E
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCGNMFVEP 431
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 386
GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 192 bits (489), Expect = 3e-49
Identities = 118/395 (29%), Positives = 196/395 (49%), Gaps = 14/395 (3%)
Query: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
L+G+ IL L + + L+ T Y P G + ++ +E+C Y+G + S SI
Sbjct: 75 LDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSIC 134
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KSTDGKQGP 119
TC GLRG +R D + + + Q+ P HTC + +S ++ P
Sbjct: 135 TCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPG-HTCALSWRESVHTQKPP 193
Query: 120 IRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNT 179
+ D + K ++L +V D++ + Y + L+ +V LL+ +
Sbjct: 194 EHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYRDFQHLLNR-TLEVALLLDTFFRP 252
Query: 180 IDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSGISFNNR 238
++V+VALVG+E W+ D +++ P+ + T +NFL W ++L ++ HD AQL++G SF+
Sbjct: 253 LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGP 312
Query: 239 RVGLAASNSLCSPSSVAVIEAKKKNNV-ALVGVMSHELGHVLGMP-DVPFNT-----KCP 291
VG+A NS+CSP + ++ + ++HELGH LG+ D+P N+ P
Sbjct: 313 TVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAP 372
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
+ +C+M +FS R E+ LL CL + +P+ CGN +E
Sbjct: 373 AKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFER-LPSLPPMAAFCGNMFVEP 431
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAP 386
GE CDCG +C + CC++LTC+L+PG C D P
Sbjct: 432 GEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGP 466
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 162 bits (410), Expect = 5e-40
Identities = 109/385 (28%), Positives = 177/385 (45%), Gaps = 34/385 (8%)
Query: 14 KTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTH 73
K ++ L ++ LY+ +G T + CYY+GNI +S+ ++STC GLRG
Sbjct: 65 KQRYFLADNFMIYLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGILQF 123
Query: 74 HHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKED 133
+ Y I+PL+S E +H ++ E+ D A I I RSLK +D
Sbjct: 124 ENVSYGIEPLESAVEFQHVLYKLKNEDNDIA---------------IFIDRSLKEQPMDD 168
Query: 134 FLRAQK------------YIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTID 181
+ + Y+++++V+D Y + + ++ + V +++ L N ++
Sbjct: 169 NIFISEKSEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFK 228
Query: 182 VQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVG 241
V + L +E+WSD +KI V A FL W S L + HD A LL + + R +G
Sbjct: 229 VTIVLSSLELWSDENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDY-PRYLG 287
Query: 242 LAASNSLCSP--SSVAVIEAKKKNNVALVGVMSHELGHVLGMP-DVPFNTKCPSGSCVMN 298
++C S+ + K+ A +++ L LG+ D P +C +C+MN
Sbjct: 288 AVFPGTMCITRYSAGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMN 347
Query: 299 -QYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDC 357
+ + S K FS+ F+ ++ + KCL P PVCGN LE E CDC
Sbjct: 348 PEVVQSNGVKTFSSCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDC 407
Query: 358 GSPKEC-TNLCCEALTCKLKPGTDC 381
G+ +C CC+ TC LK G C
Sbjct: 408 GTEAQCGPASCCDFRTCVLKDGAKC 432
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 152 bits (383), Expect = 7e-37
Identities = 106/391 (27%), Positives = 188/391 (48%), Gaps = 22/391 (5%)
Query: 1 MILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVAS 60
+++ G+ ++L + K+ L ++ YS G + C+Y+G I SV
Sbjct: 49 IVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVM 107
Query: 61 ISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHT-CGVKSTDGKQGP 119
+STC GLRG + Y I+PL+S+ EH ++ ++ D + + ++S D
Sbjct: 108 VSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRD----- 162
Query: 120 IRISRSLKSPE-KEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYN 178
+S L+S E ++DF KYI+++++++ Y + + T++ VF ++ L N I+
Sbjct: 163 --LSFKLQSVEPQQDFA---KYIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFV 217
Query: 179 TIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNR 238
+ ++ + L +E+W D +KI A+ FLRW +S L + HD A LL +N
Sbjct: 218 SFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLVLRPHDVAFLLVYREKSN- 276
Query: 239 RVGLAASNSLCSPSSV--AVIEAKKKNNVALVGVMSHELGHVLGMPDVPFN-TKCPSGSC 295
VG +C + V+ + + +L +++ L +G+ N +C C
Sbjct: 277 YVGATFQGKMCDANYAGGVVLHPRTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVC 336
Query: 296 VMN-QYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAP-IPTNIMTTPVCGNHLLEVGE 353
+MN + + K FS F ++ QK +CL P + VCGN LE GE
Sbjct: 337 IMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGE 396
Query: 354 DCDCGSPKECT---NLCCEALTCKLKPGTDC 381
+CDCG+ ++C CC+ TC+ K G++C
Sbjct: 397 ECDCGTEQDCALIGETCCDIATCRFKAGSNC 427
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 149 bits (376), Expect = 4e-36
Identities = 101/383 (26%), Positives = 173/383 (45%), Gaps = 10/383 (2%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G+ I+ ++ K L Y+ + + +P + CYY G + S+ ++STC
Sbjct: 119 GQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPESLVALSTC 178
Query: 65 DG-LRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGV---KSTDGKQGPI 120
G G + Y+IKP+ + EH V+ + ++ CG+ K + +
Sbjct: 179 SGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQL 238
Query: 121 RISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTI 180
+ +LK + Q++++L +V+DN Y N T ++ VF+V+N+++ Y+ +
Sbjct: 239 SYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSFYHPL 298
Query: 181 DVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSGISFNNRR 239
+V V L G++IW+ + + ++F W + NL ++ HD A L +
Sbjct: 299 EVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIK-DTQGMK 357
Query: 240 VGLAASNSLC-SPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMN 298
+G+A +C +P + V + V + HELGH LGM C C+M+
Sbjct: 358 LGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDTQWCVCELQWCIMH 417
Query: 299 QYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCG 358
Y K FS A + +S C+ P P NI CGN ++E GE+CDCG
Sbjct: 418 AY--RKVTTKFSNCSYAQYWDSTIS-SGLCIQPPPYPGNIFRLKYCGNLVVEEGEECDCG 474
Query: 359 SPKECTNLCCEALTCKLKPGTDC 381
+ ++C C L C L PG C
Sbjct: 475 TIRQCAKDPCCLLNCTLHPGAAC 497
>gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
Length = 739
Score = 148 bits (373), Expect = 9e-36
Identities = 106/390 (27%), Positives = 179/390 (45%), Gaps = 18/390 (4%)
Query: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
++G+ L L K + L ++ Y+ G + P M HC+Y+G NS ++S
Sbjct: 51 IDGQPYTLHLGK-QSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLS 109
Query: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRI 122
C GLRG+ + Y I+P++S+ EH ++ + + + K P ++
Sbjct: 110 ICSGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKV 169
Query: 123 SRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDV 182
L S K +Y+++Y++++ A Y + + + V+ L+N ++ +
Sbjct: 170 P--LNSQIKNLSKLLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKL 227
Query: 183 QVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGL 242
V L +E+WS+ ++I A FL W L + HD A LL + + VG
Sbjct: 228 TVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLV-YRKHPKYVGA 286
Query: 243 AASNSLCSPSSVAVIEAKKKNNVALVG---VMSHELGHVLGMP-DVPFNTKCPSGSCVMN 298
++C+ S A I A + + L G +++ LG +G+ D C +C+MN
Sbjct: 287 TFPGTVCNKSYDAGI-AMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQCFCLRATCIMN 345
Query: 299 QYLSSKFPKDFSTSCRAHFERYLLSQ-KPKCLLQ----APIPTNIMTTPVCGNHLLEVGE 353
S + ++C H RY +S+ + KCL + P+ N PVCGN +LE E
Sbjct: 346 HEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQN---QPVCGNGILESNE 402
Query: 354 DCDCGSPKECT-NLCCEALTCKLKPGTDCG 382
+CDCG+ EC CC+ TCKLK CG
Sbjct: 403 ECDCGNKNECQFKKCCDYNTCKLKGSVKCG 432
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 143 bits (361), Expect = 2e-34
Identities = 100/390 (25%), Positives = 180/390 (46%), Gaps = 25/390 (6%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G++ I+ ++ K L Y+ +G + +P +CYY G + + S+ S+STC
Sbjct: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
Query: 65 -DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRIS 123
G +G + Y+IKPL + EH V+ + EE+ + G + I+
Sbjct: 120 FGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE-------IT 172
Query: 124 RSLKSPEKEDFLRAQ----------KYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 173
++ E ++ + Q + +++ +V+DN Y Y N + + ++ ++N++
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
Query: 174 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 232
+ I + I V+V L G+EIW++ + I VV + + +W S N+ ++ HD + L +
Sbjct: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
Query: 233 ISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCP 291
+ G+ A +C+P S A++ K ++H LGH LGM +C
Sbjct: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCS 350
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
C+M++ + FS F Y + ++ KCLL+ +I CGN ++E
Sbjct: 351 QPRCIMHE--GNPPITKFSNCSYGDFWEYTV-ERTKCLLETVHTKDIFNVKRCGNGVVEE 407
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDC 381
GE+CDCG K C C C L G+ C
Sbjct: 408 GEECDCGPLKHCAKDPCCLSNCTLTDGSTC 437
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 143 bits (361), Expect = 2e-34
Identities = 100/390 (25%), Positives = 180/390 (46%), Gaps = 25/390 (6%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G++ I+ ++ K L Y+ +G + +P +CYY G + + S+ S+STC
Sbjct: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
Query: 65 -DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRIS 123
G +G + Y+IKPL + EH V+ + EE+ + G + I+
Sbjct: 120 FGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE-------IT 172
Query: 124 RSLKSPEKEDFLRAQ----------KYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 173
++ E ++ + Q + +++ +V+DN Y Y N + + ++ ++N++
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
Query: 174 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 232
+ I + I V+V L G+EIW++ + I VV + + +W S N+ ++ HD + L +
Sbjct: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
Query: 233 ISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCP 291
+ G+ A +C+P S A++ K ++H LGH LGM +C
Sbjct: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCS 350
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
C+M++ + FS F Y + ++ KCLL+ +I CGN ++E
Sbjct: 351 QPRCIMHE--GNPPITKFSNCSYGDFWEYTV-ERTKCLLETVHTKDIFNVKRCGNGVVEE 407
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDC 381
GE+CDCG K C C C L G+ C
Sbjct: 408 GEECDCGPLKHCAKDPCCLSNCTLTDGSTC 437
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 143 bits (361), Expect = 2e-34
Identities = 100/390 (25%), Positives = 180/390 (46%), Gaps = 25/390 (6%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G++ I+ ++ K L Y+ +G + +P +CYY G + + S+ S+STC
Sbjct: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
Query: 65 -DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRIS 123
G +G + Y+IKPL + EH V+ + EE+ + G + I+
Sbjct: 120 FGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE-------IT 172
Query: 124 RSLKSPEKEDFLRAQ----------KYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 173
++ E ++ + Q + +++ +V+DN Y Y N + + ++ ++N++
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
Query: 174 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 232
+ I + I V+V L G+EIW++ + I VV + + +W S N+ ++ HD + L +
Sbjct: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
Query: 233 ISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCP 291
+ G+ A +C+P S A++ K ++H LGH LGM +C
Sbjct: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCS 350
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
C+M++ + FS F Y + ++ KCLL+ +I CGN ++E
Sbjct: 351 QPRCIMHE--GNPPITKFSNCSYGDFWEYTV-ERTKCLLETVHTKDIFNVKRCGNGVVEE 407
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDC 381
GE+CDCG K C C C L G+ C
Sbjct: 408 GEECDCGPLKHCAKDPCCLSNCTLTDGSTC 437
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 143 bits (361), Expect = 2e-34
Identities = 100/390 (25%), Positives = 180/390 (46%), Gaps = 25/390 (6%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G++ I+ ++ K L Y+ +G + +P +CYY G + + S+ S+STC
Sbjct: 60 GQKHIIHIKVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDPESLVSLSTC 119
Query: 65 -DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRIS 123
G +G + Y+IKPL + EH V+ + EE+ + G + I+
Sbjct: 120 FGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE-------IT 172
Query: 124 RSLKSPEKEDFLRAQ----------KYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 173
++ E ++ + Q + +++ +V+DN Y Y N + + ++ ++N++
Sbjct: 173 CRMEFEEIDNSTQKQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIV 232
Query: 174 NVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKI-HDHAQLLSG 232
+ I + I V+V L G+EIW++ + I VV + + +W S N+ ++ HD + L +
Sbjct: 233 DSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTT 291
Query: 233 ISFNNRRVGLAASNSLCSPS-SVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCP 291
+ G+ A +C+P S A++ K ++H LGH LGM +C
Sbjct: 292 LGLRGLS-GIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCS 350
Query: 292 SGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEV 351
C+M++ + FS F Y + ++ KCLL+ +I CGN ++E
Sbjct: 351 QPRCIMHE--GNPPITKFSNCSYGDFWEYTV-ERTKCLLETVHTKDIFNVKRCGNGVVEE 407
Query: 352 GEDCDCGSPKECTNLCCEALTCKLKPGTDC 381
GE+CDCG K C C C L G+ C
Sbjct: 408 GEECDCGPLKHCAKDPCCLSNCTLTDGSTC 437
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 135 bits (339), Expect = 8e-32
Identities = 92/346 (26%), Positives = 160/346 (46%), Gaps = 13/346 (3%)
Query: 43 EHCYYKGNILNEKNSVASISTC-DGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQ 101
+ CYY G + S+ S C G RG Y+I+P++ + EH V+ N E
Sbjct: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNET 166
Query: 102 DPANHTCGVKSTDGKQGPIRISRS----LKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNE 157
CG+ + + + + L+ D+ +++L +V+++ F+
Sbjct: 167 QFPAMRCGLTEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQS 226
Query: 158 NLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSS 217
N++ ++ VF V+N+++ +Y + + L+G+EIW+ G+ + S ++F +W
Sbjct: 227 NISKVQEDVFLVVNIVDSMYQQLGTYIILIGIEIWNQGNVFPMT-SIEQVLNDFSQWKQI 285
Query: 218 NLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVAL-VGVMSHELG 276
+L + HD A + S + +GLA +C P ++ + + +L ++HELG
Sbjct: 286 SLSQLQHDAAHMFIKNSLISI-LGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELG 344
Query: 277 HVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCR-AHFERYLLSQKPKCLLQAPIP 335
H LGM C C+MN + + P + T+C A F + L+Q CL P
Sbjct: 345 HTLGMQHDEEFCFCGERGCIMNTF---RVPAEKFTNCSYADFMKTTLNQG-SCLHNPPRL 400
Query: 336 TNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 381
I CGN ++E E CDCGS ++C C L C L+PG C
Sbjct: 401 GEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAAC 446
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 134 bits (336), Expect = 2e-31
Identities = 107/400 (26%), Positives = 174/400 (43%), Gaps = 34/400 (8%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G IL + LL +Y E G+ + K EHCYY+G+I +S ++STC
Sbjct: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVK--GGEHCYYQGHIRGNPDSFVALSTC 154
Query: 65 DGLRGYFTHHHQRYQIKPLKSTDEKE----HAVFTSNQEE---QDPANHTCGVKSTDG-- 115
GL G F + Y I+P ++ +E H+V+ S E D + V T
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKF 214
Query: 116 --KQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 173
K P R R L+ + + KYI+L +V D+ +K + ++ ++ V+N+
Sbjct: 215 ILKPRPKRSKRQLRRYPR-NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMA 273
Query: 174 NVIY-NTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSG 232
++IY + + ++ LV ME W+ +K + + T F+++ + +K D L SG
Sbjct: 274 DLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK-SDAVHLFSG 332
Query: 233 ISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPS 292
F + R G A +CS + K ++ V ++ L H +G+ + K S
Sbjct: 333 SQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV-TLAQSLAHNIGI--ISDKRKLAS 389
Query: 293 GSCVMNQYLSS--------KFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVC 344
G C S PK F+ + +L S CL P+ ++ P C
Sbjct: 390 GECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK--PSKLLDPPEC 447
Query: 345 GNHLLEVGEDCDCGSPKECT---NLCCEALTCKLKPGTDC 381
GN +E GE+CDCG+P EC CC+ C L + C
Sbjct: 448 GNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQC 485
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 134 bits (336), Expect = 2e-31
Identities = 107/400 (26%), Positives = 174/400 (43%), Gaps = 34/400 (8%)
Query: 5 GEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTC 64
G IL + LL +Y E G+ + K EHCYY+G+I +S ++STC
Sbjct: 97 GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVK--GGEHCYYQGHIRGNPDSFVALSTC 154
Query: 65 DGLRGYFTHHHQRYQIKPLKSTDEKE----HAVFTSNQEE---QDPANHTCGVKSTDG-- 115
GL G F + Y I+P ++ +E H+V+ S E D + V T
Sbjct: 155 HGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKF 214
Query: 116 --KQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLL 173
K P R R L+ + + KYI+L +V D+ +K + ++ ++ V+N+
Sbjct: 215 ILKPRPKRSKRQLRRYPR-NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMA 273
Query: 174 NVIY-NTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSG 232
++IY + + ++ LV ME W+ +K + + T F+++ + +K D L SG
Sbjct: 274 DLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK-SDAVHLFSG 332
Query: 233 ISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPS 292
F + R G A +CS + K ++ V ++ L H +G+ + K S
Sbjct: 333 SQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV-TLAQSLAHNIGI--ISDKRKLAS 389
Query: 293 GSCVMNQYLSS--------KFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVC 344
G C S PK F+ + +L S CL P+ ++ P C
Sbjct: 390 GECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK--PSKLLDPPEC 447
Query: 345 GNHLLEVGEDCDCGSPKECT---NLCCEALTCKLKPGTDC 381
GN +E GE+CDCG+P EC CC+ C L + C
Sbjct: 448 GNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQC 485
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,037,099
Number of Sequences: 37866
Number of extensions: 737612
Number of successful extensions: 2021
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 1819
Number of HSP's gapped (non-prelim): 92
length of query: 391
length of database: 18,247,518
effective HSP length: 104
effective length of query: 287
effective length of database: 14,309,454
effective search space: 4106813298
effective search space used: 4106813298
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.