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Search of human proteins with 114326453
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
(754 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 1602 0.0
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 559 e-159
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot... 433 e-121
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 387 e-107
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 385 e-106
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 382 e-106
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 366 e-101
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 365 e-101
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 338 8e-93
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 328 1e-89
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 315 1e-85
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 314 2e-85
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 314 2e-85
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 314 2e-85
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 314 2e-85
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 314 2e-85
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 313 3e-85
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 313 3e-85
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 313 3e-85
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 312 6e-85
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 302 7e-82
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 298 1e-80
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 295 1e-79
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 293 3e-79
gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens] 287 2e-77
gi|7656861 a disintegrin and metalloprotease domain 18 prepropro... 281 2e-75
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s... 273 6e-73
gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens] 270 4e-72
gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens] 270 4e-72
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 267 2e-71
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 1602 bits (4148), Expect = 0.0
Identities = 754/754 (100%), Positives = 754/754 (100%)
Query: 1 MLPGCIFLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEELL 60
MLPGCIFLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEELL
Sbjct: 1 MLPGCIFLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEELL 60
Query: 61 YEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSA 120
YEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSA
Sbjct: 61 YEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSA 120
Query: 121 ASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTV 180
ASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTV
Sbjct: 121 ASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTV 180
Query: 181 PGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTL 240
PGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTL
Sbjct: 181 PGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTL 240
Query: 241 NIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHV 300
NIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHV
Sbjct: 241 NIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHV 300
Query: 301 QGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMD 360
QGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMD
Sbjct: 301 QGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMD 360
Query: 361 SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGP 420
SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGP
Sbjct: 361 SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGP 420
Query: 421 AQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSPAC 480
AQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSPAC
Sbjct: 421 AQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSPAC 480
Query: 481 PKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYCK 540
PKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYCK
Sbjct: 481 PKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYCK 540
Query: 541 NKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTD 600
NKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTD
Sbjct: 541 NKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTD 600
Query: 601 IGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVAC 660
IGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVAC
Sbjct: 601 IGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVAC 660
Query: 661 EETLHVTNITILVVVLVLVIVGIGVLILLVRYRKCIKLKQVQSPPTETLGVENKGYFGDE 720
EETLHVTNITILVVVLVLVIVGIGVLILLVRYRKCIKLKQVQSPPTETLGVENKGYFGDE
Sbjct: 661 EETLHVTNITILVVVLVLVIVGIGVLILLVRYRKCIKLKQVQSPPTETLGVENKGYFGDE 720
Query: 721 QQIRTEPILPEIHFLNKPASKDSRGIADPNQSAK 754
QQIRTEPILPEIHFLNKPASKDSRGIADPNQSAK
Sbjct: 721 QQIRTEPILPEIHFLNKPASKDSRGIADPNQSAK 754
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 559 bits (1440), Expect = e-159
Identities = 294/728 (40%), Positives = 420/728 (57%), Gaps = 40/728 (5%)
Query: 1 MLPGCIFLMILLIPQVKE-KFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEEL 59
ML G + + +LL V K + GV+ ++V P +L + KR+ + +E EL
Sbjct: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQE---QFETEL 57
Query: 60 LYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDS 119
Y++ +N K VL+L +++ L Y+ET+Y+ G+ T PQIMD C+YQG I++E S
Sbjct: 58 KYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVS 117
Query: 120 AASISTCNGLRGFFRINDQRYLIEPVK--YSDEGEHLVFKYNLRVPYGANYSCT------ 171
ASISTC GLRG+F DQRY IEP+ + D EH +FKYN P NY T
Sbjct: 118 DASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYN---PDEKNYDSTCGMDGV 174
Query: 172 ----ELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIW 227
+L +D K++ EKY+E ++V D+ ++R +++R R++
Sbjct: 175 LWAHDLQQNIALPATKLVKLKDRKVQ--EHEKYIEYYLVLDNGEFKRYNENQDEIRKRVF 232
Query: 228 GMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDH 287
M N+VNM+YK LN HV LVG+EIWT +DKI++ N TL FS W+ +L RK D
Sbjct: 233 EMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDI 292
Query: 288 VVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDE 347
L++ L G+++ MC PY S +++D + +A MAH++GHN GM HD+
Sbjct: 293 AQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD 351
Query: 348 FPCTCPSGKCVMDSDGS--IPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
+ C CPS CVMD S IP FS CS+ Y ++ +D C+ N P P + C
Sbjct: 352 YSCKCPSTICVMDKALSFYIPT-DFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPIC 410
Query: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKD 465
GN+ ++ GE+CDCG ++ECTN CCDA TC +K F CA GECCE CQ KKAG +CRPAKD
Sbjct: 411 GNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKD 470
Query: 466 ECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDI 525
ECD PEMC G S CP D+F+VNGFPC + +G+C MG CPT ++QC+EL+ +
Sbjct: 471 ECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELWGPGTEVADKS 530
Query: 526 CYKMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNA 585
CY N G+K+GYC+ ++ +PC+ D CGK++C GG + P K
Sbjct: 531 CYNRNEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGSDNL------------PWKGR 578
Query: 586 TV---KCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPV 642
V CKT S +IG+VA+GTKCG+ VC N EC+++EK Y STNC S+C + V
Sbjct: 579 IVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDIEKAYKSTNCSSKCKGHAV 638
Query: 643 DGHGLQCHCEEGQAPVACEETLHVTNITILVVVLVLVIVGIGVLILLVRYRKCIKLKQVQ 702
H LQC CEEG P C+++ V + +I+V VL + V V+ +++R++ + ++
Sbjct: 639 CDHELQCQCEEGWIPPDCDDSSVVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKD 698
Query: 703 SPPTETLG 710
P T G
Sbjct: 699 QRPLSTTG 706
>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
[Homo sapiens]
Length = 540
Score = 433 bits (1113), Expect = e-121
Identities = 225/530 (42%), Positives = 315/530 (59%), Gaps = 25/530 (4%)
Query: 1 MLPGCIFLMILLIPQVKE-KFILGVEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEEL 59
ML G + + +LL V K + GV+ ++V P +L + KR+ + +E EL
Sbjct: 1 MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQE---QFETEL 57
Query: 60 LYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDS 119
Y++ +N K VL+L +++ L Y+ET+Y+ G+ T PQIMD C+YQG I++E S
Sbjct: 58 KYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEKVS 117
Query: 120 AASISTCNGLRGFFRINDQRYLIEPVK--YSDEGEHLVFKYNLRVPYGANYSCT------ 171
ASISTC GLRG+F DQRY IEP+ + D EH +FKYN P NY T
Sbjct: 118 DASISTCRGLRGYFSQGDQRYFIEPLSPIHRDGQEHALFKYN---PDEKNYDSTCGMDGV 174
Query: 172 ----ELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIW 227
+L +D K++ EKY+E ++V D+ ++R +++R R++
Sbjct: 175 LWAHDLQQNIALPATKLVKLKDRKVQ--EHEKYIEYYLVLDNGEFKRYNENQDEIRKRVF 232
Query: 228 GMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDH 287
M N+VNM+YK LN HV LVG+EIWT +DKI++ N TL FS W+ +L RK D
Sbjct: 233 EMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDI 292
Query: 288 VVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDE 347
L++ L G+++ MC PY S +++D + +A MAH++GHN GM HD+
Sbjct: 293 AQLITATELAGTTVGLAFMSTMCSPY-SVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDD 351
Query: 348 FPCTCPSGKCVMDSDGS--IPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
+ C CPS CVMD S IP FS CS+ Y ++ +D C+ N P P + C
Sbjct: 352 YSCKCPSTICVMDKALSFYIPT-DFSSCSRLSYDKFFEDKLSNCLFNAPLPTDIISTPIC 410
Query: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKD 465
GN+ ++ GE+CDCG ++ECTN CCDA TC +K F CA GECCE CQ KKAG +CRPAKD
Sbjct: 411 GNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQFKKAGMVCRPAKD 470
Query: 466 ECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELF 515
ECD PEMC G S CP D+F+VNGFPC + +G+C MG CPT ++QC+EL+
Sbjct: 471 ECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCTELW 520
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 387 bits (994), Expect = e-107
Identities = 223/672 (33%), Positives = 346/672 (51%), Gaps = 35/672 (5%)
Query: 53 KTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFT---RHPQIMDHCFY 109
K + E L ++ K L+++L R+ + S+++ET Y G + + I+ HC+Y
Sbjct: 62 KNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYY 121
Query: 110 QGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKY----NLRVPYG 165
G + DSA S+STC+GLRG ++ Y++EP+K S + +F ++R G
Sbjct: 122 HGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMK-SATNRYKLFPAKKLKSVRGSCG 180
Query: 166 ANYSCTELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNR 225
++++ L P K + + KYVEL IVAD+ ++R G K++ R
Sbjct: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
Query: 226 IWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDF 285
+ + N V+ Y+ LNI + LVG+E+W DK + + T+L F W++ L RK
Sbjct: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
Query: 286 DHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQH 345
D+ L+SG + G++ MC S I+ D + A +AH+LGHN GM H
Sbjct: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
Query: 346 DEFP--CTCP----SGKCVMDSDGSIP-ALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYN 398
D C+C G C+M++ P + FS CS+ L+ C+ N+P
Sbjct: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
Query: 399 FHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGS 458
Q CGN+ ++EGEECDCG +EC N CC+A TC LKP CA G CCE CQ+K AG+
Sbjct: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
Query: 459 ICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDE 518
CR + + CD PE CTG SP CP + + +G C++ +GYC+ G C T E QC L+
Sbjct: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
Query: 519 AIESHDICY-KMNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDK-T 575
A + IC+ ++N+ G+ +G C K ++ F CE +D +CGKI C GG ++G + +
Sbjct: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
Query: 576 YHLKDP-QKNATVKCK--TIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTN 632
P Q+ + C+ ++L D D GLV +GTKC +G +C N +C N+ V+
Sbjct: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNI-SVFGVHE 659
Query: 633 CPSQCNENPVDGHGLQCHCEEGQAPVACEE-------------TLHVTNITILVVVLVLV 679
C QC+ V + CHCE AP C++ +TI ++V +L
Sbjct: 660 CAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILC 719
Query: 680 IVGIGVLILLVR 691
++ G ++ L R
Sbjct: 720 LLAAGFVVYLKR 731
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 385 bits (988), Expect = e-106
Identities = 216/630 (34%), Positives = 331/630 (52%), Gaps = 22/630 (3%)
Query: 53 KTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFT---RHPQIMDHCFY 109
K + E L ++ K L+++L R+ + S+++ET Y G + + I+ HC+Y
Sbjct: 62 KNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYY 121
Query: 110 QGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKY----NLRVPYG 165
G + DSA S+STC+GLRG ++ Y++EP+K S + +F ++R G
Sbjct: 122 HGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMK-SATNRYKLFPAKKLKSVRGSCG 180
Query: 166 ANYSCTELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNR 225
++++ L P K + + KYVEL IVAD+ ++R G K++ R
Sbjct: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
Query: 226 IWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDF 285
+ + N V+ Y+ LNI + LVG+E+W DK + + T+L F W++ L RK
Sbjct: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
Query: 286 DHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQH 345
D+ L+SG + G++ MC S I+ D + A +AH+LGHN GM H
Sbjct: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
Query: 346 DEFP--CTCP----SGKCVMDSDGSIP-ALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYN 398
D C+C G C+M++ P + FS CS+ L+ C+ N+P
Sbjct: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
Query: 399 FHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGS 458
Q CGN+ ++EGEECDCG +EC N CC+A TC LKP CA G CCE CQ+K AG+
Sbjct: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
Query: 459 ICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDE 518
CR + + CD PE CTG SP CP + + +G C++ +GYC+ G C T E QC L+
Sbjct: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
Query: 519 AIESHDICY-KMNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDK-T 575
A + IC+ ++N+ G+ +G C K ++ F CE +D +CGKI C GG ++G + +
Sbjct: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
Query: 576 YHLKDP-QKNATVKCK--TIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTN 632
P Q+ + C+ ++L D D GLV +GTKC +G +C N +C N+ V+
Sbjct: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNI-SVFGVHE 659
Query: 633 CPSQCNENPVDGHGLQCHCEEGQAPVACEE 662
C QC+ V + CHCE AP C++
Sbjct: 660 CAMQCHGRGVCNNRKNCHCEAHWAPPFCDK 689
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 382 bits (981), Expect = e-106
Identities = 210/661 (31%), Positives = 339/661 (51%), Gaps = 43/661 (6%)
Query: 68 KTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCN 127
+ L+L L ++ + +Y+ET Y+ G T ++ DHCFY G++ S+ ++STC
Sbjct: 74 RELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCR 133
Query: 128 GLRGFFRINDQ-RYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTE---------LNFTR 177
G+RG ++ Y+IEP+ S +G+HL+++ P N L FT+
Sbjct: 134 GIRGLITVSSNLSYVIEPLPDS-KGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQ 192
Query: 178 KTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIY 237
+T + K + ++ KYVEL++VAD +++N + ++++ + N+V+ Y
Sbjct: 193 QT----KKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFY 248
Query: 238 KTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLY 297
++LNI + LVG+E+WTH + E+ N +TL F W+ K+L +K D+ L++G +
Sbjct: 249 RSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLL-AQKYHDNAQLITGMSFH 307
Query: 298 SHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPS--- 354
G++ MC Y S + D + +A MAH++GHN GM HD C S
Sbjct: 308 GTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAAD 367
Query: 355 GKCVMDSDGSIPALK-FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEG 413
G C+M + P K F+ C++ + +YL+ C+ N+P + + CGN L++G
Sbjct: 368 GGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDG 427
Query: 414 EECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMC 473
EECDCG +EC NPCC+A C L+PG CA G CC C++ G++CR +CD PE C
Sbjct: 428 EECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPEFC 487
Query: 474 TGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICY-KMNTK 532
TG SP CP + ++++G PC+ + YC+ G C T ++QC +L+ A + D+C+ K+N
Sbjct: 488 TGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVA 547
Query: 533 GNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKT 591
G+ FG C K+ C +D +CGKI C E L ++C+
Sbjct: 548 GDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRG 607
Query: 592 IFLYH------DSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGH 645
+Y D D GLV +GTKCG +C G+C N + + C +CN + V +
Sbjct: 608 THVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRN-TSFFETEGCGKKCNGHGVCNN 666
Query: 646 GLQCHCEEGQAPVACEETLHVTNI-----------TILVVVLVLVIVGIGVLILLVRYRK 694
CHC G AP C H +I ++ VLV ++V + +L++ Y
Sbjct: 667 NQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILV---LAVLMLMYYC 723
Query: 695 C 695
C
Sbjct: 724 C 724
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 366 bits (939), Expect = e-101
Identities = 200/621 (32%), Positives = 316/621 (50%), Gaps = 18/621 (2%)
Query: 53 KTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGS 112
+ Y +++ Y I+ K ++HL R+++ L ++ Y+ +G T HP I +HC Y+G
Sbjct: 60 RPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGY 119
Query: 113 IVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYN--LRVPYGANYSC 170
+ ++S+ ++S C GLRG + + Y IEP++ S EH++++ + + P S
Sbjct: 120 VEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSN 179
Query: 171 TELNFTRKTVPGDNESEEDSKIKGIH-------DEKYVELFIVADDTVYRRNGHPHNKLR 223
++ K D E E S + + +YVELFIV D Y G +R
Sbjct: 180 KDIE---KETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVR 236
Query: 224 NRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRK 283
+ + N+++ +Y LNI + LVG+EIWT+ + I + L F W+EK L TR+
Sbjct: 237 EEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRR 296
Query: 284 DFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGM 343
D L+ K + G+++ G +C ++ I A+ +AH+LGHNLGM
Sbjct: 297 RHDSAQLVLKKG-FGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGM 355
Query: 344 QHDEF-PCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDF 402
HD+ C+C + C+M+S G+ + FS CS + + + C+LNIP P +
Sbjct: 356 NHDDGRDCSCGAKSCIMNS-GASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSA 414
Query: 403 QFCGNKKLDEGEECDCGPAQECT-NPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICR 461
CGNK +D GEECDCG +EC +PCC+ TC LK CA G+CC+ C+ G++CR
Sbjct: 415 PSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCR 474
Query: 462 PAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIE 521
ECD PE C G S C D F NG+PC+N++ YC+ G C + QC +F +A
Sbjct: 475 GKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKA 534
Query: 522 SHDICY-KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKD 580
+ C+ ++N+KG++FG C N + C + CGK+ C + + G ++
Sbjct: 535 APKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAI-IQT 593
Query: 581 PQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNEN 640
P + L D D G+V GTKCG G +C N +C++ + + +C+ +
Sbjct: 594 PSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGH 653
Query: 641 PVDGHGLQCHCEEGQAPVACE 661
V CHCE G AP CE
Sbjct: 654 GVCNSNKNCHCENGWAPPNCE 674
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 365 bits (937), Expect = e-101
Identities = 236/715 (33%), Positives = 352/715 (49%), Gaps = 65/715 (9%)
Query: 24 VEGQQLVRPKKLPLIQKRDTGHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGS 83
+E ++V P +LP + R +H L + E + Y + LHL ++R+ LGS
Sbjct: 26 MEQYEVVLPWRLPGPRVRRALPSH----LGLHPERVSYVLGATGHNFTLHLRKNRDLLGS 81
Query: 84 NYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIE 143
Y+ET+ + G T P+ DHCFYQG + DSAAS+STC GLRGFF++ +LIE
Sbjct: 82 GYTETYTAANGSEVTEQPRGQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIE 141
Query: 144 PVKYSDEG-EHLVFKYNLRVPYGANYSCTELNFTR----------KTVPGDNESEEDSKI 192
P+ EG H V++ + ++ + + PGD+ +++
Sbjct: 142 PLDEGGEGGRHAVYQAEHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPSRETR- 200
Query: 193 KGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIW 252
YVEL++V D+ ++ G +R+R+ +VN V+ +Y+ LN V LVG+EIW
Sbjct: 201 -------YVELYVVVDNAEFQMLGS-EAAVRHRVLEVVNHVDKLYQKLNFRVVLVGLEIW 252
Query: 253 THEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQGISYPGGMCLP 312
+D+ + + TL WQ + R D+V L++G G + MC
Sbjct: 253 NSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMC-S 311
Query: 313 YYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFP--CTCP----SGKCVM-DSDGSI 365
+ S ++ +D + +A MAH++GHNLGM HDE C C +G+C+M S GS
Sbjct: 312 HSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERFEAGRCIMAGSIGSS 371
Query: 366 PALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECT 425
FS CSQ +L+ + C+ N P + CGN ++ GE+CDCGP ++C
Sbjct: 372 FPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDCR 431
Query: 426 NPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQF 485
N CC++ TC L G CA G CC+ C++K AG +CRP KD CD E C G P CP+D F
Sbjct: 432 NRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAF 491
Query: 486 RVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYKMNTKGNKFGYCKNKENR 545
+ NG PC S GYC+ G CPT QC + + + C+ + CK R
Sbjct: 492 QENGTPC--SGGYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPG----CKASRYR 545
Query: 546 FLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKCKTIFLYHDSTDIGLVA 605
D+ CG + C GG+ LG + + D T + D T V
Sbjct: 546 ------ADM-CGVLQCKGGQ--QPLG--RAICIVDVCHALTTE--------DGTAYEPVP 586
Query: 606 SGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDGHGLQCHCEEGQAPVACEETL- 664
GT+CG VC G C ++ VY S+NC +QC+ + V H +CHC G AP C + L
Sbjct: 587 EGTRCGPEKVCWKGRCQDLH-VYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAKLLT 645
Query: 665 --HVTNITI---LVVVLVLVIVGIGVLILLVRYRKC-IKLKQVQSPPTETLGVEN 713
H + ++ +VVVLVL+ V + L ++ YRK ++ P T+G N
Sbjct: 646 EVHAASGSLPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRNVAPKTTMGRSN 700
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 338 bits (868), Expect = 8e-93
Identities = 201/622 (32%), Positives = 300/622 (48%), Gaps = 25/622 (4%)
Query: 60 LYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDS 119
L ++ + L+L L ++ L Y ET Y G+ P DHC YQG + DS
Sbjct: 67 LVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDS 126
Query: 120 AASISTCNGLRGFFRIN-DQRYLIEPVK---YSDEGEHLVFKYNLRVPYGANYSCTELNF 175
+ TC+G+ G ++ + Y + P D H +F+ + + +C +
Sbjct: 127 WVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG--TCGHRDP 184
Query: 176 TRK----TVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVN 231
K ++PG +S + + KY+EL+IVAD T++ N + R+ + N
Sbjct: 185 GNKAGMTSLPGGPQSRGRREAR--RTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVAN 242
Query: 232 FVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLL 291
+V+ + +TL+I V L G+E+WT D+ + + TL F W+ L ++ D LL
Sbjct: 243 YVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLL 301
Query: 292 SGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC- 350
+G+ G++ GMC S + D A MAH++GH+LG+ HD C
Sbjct: 302 TGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCC 361
Query: 351 ---TCPSGKCVMDSDGSIPALK-FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCG 406
SG CVM + P + FS CS+ Q + + C+ N P P CG
Sbjct: 362 VEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCG 421
Query: 407 NKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDE 466
N ++ GEECDCGP QEC + CC AH C L+PG CA G+CC C +K AG++CR A +
Sbjct: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
Query: 467 CDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDIC 526
CD PE CTG S CP D + ++G PC GYC+ G CPT E QC +L+ + + + C
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
Query: 527 YK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSL----LGEDKTYHLKD 580
++ +N+ G+ G C ++ E FLPC +D CGK+ C GG+ S L + D T HL
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDG 601
Query: 581 PQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNEN 640
+ D +GLV GT+CG MVC + C C + C+ +
Sbjct: 602 QEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRC-RKNAFQELQRCLTACHSH 660
Query: 641 PVDGHGLQCHCEEGQAPVACEE 662
V CHC G AP C++
Sbjct: 661 GVCNSNHNCHCAPGWAPPFCDK 682
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 328 bits (840), Expect = 1e-89
Identities = 200/622 (32%), Positives = 296/622 (47%), Gaps = 51/622 (8%)
Query: 60 LYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDS 119
L ++ + L+L L ++ L Y ET Y G+ P DHC YQG + DS
Sbjct: 67 LVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDS 126
Query: 120 AASISTCNGLRGFFRIN-DQRYLIEPVK---YSDEGEHLVFKYNLRVPYGANYSCTELNF 175
+ TC+G+ G ++ + Y + P D H +F+ + + +C +
Sbjct: 127 WVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKG--TCGHRDP 184
Query: 176 TRK----TVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVN 231
K ++PG +S + + KY+EL+IVAD T++ N + R+ + N
Sbjct: 185 GNKAGMTSLPGGPQSRGRREAR--RTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVAN 242
Query: 232 FVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLL 291
+V+ + +TL+I V L G+E+WT D+ + + TL F W+ L ++ D LL
Sbjct: 243 YVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRG-LWAQRPHDSAQLL 301
Query: 292 SGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC- 350
+G+ G++ GMC S + D A MAH++GH+LG+ HD C
Sbjct: 302 TGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCC 361
Query: 351 ---TCPSGKCVMDSDGSIPALK-FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCG 406
SG CVM + P + FS CS+ Q + + C+ N P P CG
Sbjct: 362 VEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCG 421
Query: 407 NKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDE 466
N ++ GEECDCGP QEC + CC AH C L+PG CA G+CC C +K AG++CR A +
Sbjct: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
Query: 467 CDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDIC 526
CD PE CTG S CP D + ++G PC GYC+ G CPT E QC +L+ + + + C
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
Query: 527 YK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSL----LGEDKTYHLKD 580
++ +N+ G+ G C ++ E FLPC +D CGK+ C GG+ S L + D T HL
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDG 601
Query: 581 PQKNATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNEN 640
+ D +GLV GT+CG MVCN+ N N
Sbjct: 602 QEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNS-------------------NHN 642
Query: 641 PVDGHGLQCHCEEGQAPVACEE 662
CHC G AP C++
Sbjct: 643 --------CHCAPGWAPPFCDK 656
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 315 bits (807), Expect = 1e-85
Identities = 216/721 (29%), Positives = 339/721 (47%), Gaps = 40/721 (5%)
Query: 57 EELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHE 116
E L +++L+ + +L LL++RE + + +Y G +++C YQG +
Sbjct: 67 EPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGY 126
Query: 117 YDSAASISTCNGLRGFFRINDQR-YLIEPVKYSDEGEHLVFKY-NLRVP-YGANYSCTEL 173
S SI TC+GLRG + +R Y +E +G ++ + +L +P + S E
Sbjct: 127 AGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 174 NFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNF 232
T+K + + + E K VEL IVAD + ++ L NR +
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALL 245
Query: 233 VNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS 292
++ ++ LN+ V LVG+E WT D +E+ N TL F W+ L R D L++
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
Query: 293 GKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHD----EF 348
G G++ +C P +S + D +A+ +AH+LGH+LG+ HD
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
Query: 349 PCT--CPSGKCVMD-SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
PC P+ C+M+ S +P L FS CS+ + L D +C+ P FC
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFC 424
Query: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCA-EGECCESCQIKKAGSICRPAK 464
GN ++ GE+CDCG +C +PCCD+ TC L+PG CA +G CC++CQ++ +G CRP +
Sbjct: 425 GNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTR 484
Query: 465 DECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHD 524
+CD PE C G S CP D +G PC + C G+C + QC L+ A +
Sbjct: 485 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP 544
Query: 525 ICYK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQ 582
+C + NT+GN FG C +N ++ C +D CG++ C G LLG + +
Sbjct: 545 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID 604
Query: 583 KNAT-VKCKTIF--LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNE 639
N T + C + L D L GT CG G+VC + C ++ + + C S+C+
Sbjct: 605 VNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD-LLGAQECRSKCHG 663
Query: 640 NPVDGHGLQCHCEEGQAPVACEETLHVTN------ITILVVVLVLVIVGIGVLILLVRYR 693
+ V C+CEEG AP C L T+ + L+V+LVLV++G ++
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ 723
Query: 694 KCIKLK-------QVQSPPTETLGVENKGYF--GDEQQIRTEPILPEIHFLNKPASKDSR 744
+ +LK QS P+E G + G + Q +P P KP D +
Sbjct: 724 RLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKSQGPAKPPPP-----RKPLPADPQ 778
Query: 745 G 745
G
Sbjct: 779 G 779
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 314 bits (805), Expect = 2e-85
Identities = 198/669 (29%), Positives = 327/669 (48%), Gaps = 40/669 (5%)
Query: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETF-YSMKGEAFTRHPQIMDHCFYQGSIVHEY 117
L Y + + ++H+ + ++ L S + F Y+ +G P + ++C+Y G + +
Sbjct: 52 LSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDP 110
Query: 118 DSAASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPY----GANYSCTE 172
+S S+STC G +G +IND Y I+P+ +S EHLV+K + + + E
Sbjct: 111 ESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE 170
Query: 173 LNFTRKTVPGDNESEEDSKIKG--IHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230
+ + DN +++ S G IH + VE+ +V D+ +Y R +KL ++ +V
Sbjct: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHF-RIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229
Query: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVL 290
N V+ I + + V L G+EIWT+++ I + ++ ++ + W+ + + R D L
Sbjct: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHL 288
Query: 291 LSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC 350
+ L + GI GMC P+ S +I+ + + +AH LGHNLGM HDE C
Sbjct: 289 FTTLGLRG-LSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC 347
Query: 351 TCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKL 410
C +C+M +G+ P KFS CS + +Y + + C+L + + + CGN +
Sbjct: 348 RCSQPRCIMH-EGNPPITKFSNCSYGDFWEYTVE-RTKCLLETVHTKDIFNVKRCGNGVV 405
Query: 411 DEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFP 470
+EGEECDCGP + C C C L G TCA G CC+ C+ +G +CR +ECD P
Sbjct: 406 EEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLP 465
Query: 471 EMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYK-M 529
E C G S CP D + +G PCK GYC+ C R +QC +F A + + CYK +
Sbjct: 466 EWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKEL 524
Query: 530 NTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKC 589
NT G++ G+C K ++ C DV+CG+I C + + T H + N +
Sbjct: 525 NTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHW--ARFNDIMCW 582
Query: 590 KTIF-LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNC-PSQCNENPVDGHGL 647
T + L DIG V GT+CG +C + C+++ +++NC P+ CN+ + +
Sbjct: 583 STDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAFCNKRGICNNKH 640
Query: 648 QCHCEEGQAPVAC--------------EETLHVTNITILVVVLVLVIVGIGVLILLVRYR 693
CHC P C + L ++L++V+ ++L YR
Sbjct: 641 HCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVL----FILLCCLYR 696
Query: 694 KCIKLKQVQ 702
C K K ++
Sbjct: 697 LCKKSKPIK 705
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 314 bits (805), Expect = 2e-85
Identities = 198/669 (29%), Positives = 327/669 (48%), Gaps = 40/669 (5%)
Query: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETF-YSMKGEAFTRHPQIMDHCFYQGSIVHEY 117
L Y + + ++H+ + ++ L S + F Y+ +G P + ++C+Y G + +
Sbjct: 52 LSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDP 110
Query: 118 DSAASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPY----GANYSCTE 172
+S S+STC G +G +IND Y I+P+ +S EHLV+K + + + E
Sbjct: 111 ESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE 170
Query: 173 LNFTRKTVPGDNESEEDSKIKG--IHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230
+ + DN +++ S G IH + VE+ +V D+ +Y R +KL ++ +V
Sbjct: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHF-RIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229
Query: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVL 290
N V+ I + + V L G+EIWT+++ I + ++ ++ + W+ + + R D L
Sbjct: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHL 288
Query: 291 LSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC 350
+ L + GI GMC P+ S +I+ + + +AH LGHNLGM HDE C
Sbjct: 289 FTTLGLRG-LSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC 347
Query: 351 TCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKL 410
C +C+M +G+ P KFS CS + +Y + + C+L + + + CGN +
Sbjct: 348 RCSQPRCIMH-EGNPPITKFSNCSYGDFWEYTVE-RTKCLLETVHTKDIFNVKRCGNGVV 405
Query: 411 DEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFP 470
+EGEECDCGP + C C C L G TCA G CC+ C+ +G +CR +ECD P
Sbjct: 406 EEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLP 465
Query: 471 EMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYK-M 529
E C G S CP D + +G PCK GYC+ C R +QC +F A + + CYK +
Sbjct: 466 EWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKEL 524
Query: 530 NTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKC 589
NT G++ G+C K ++ C DV+CG+I C + + T H + N +
Sbjct: 525 NTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHW--ARFNDIMCW 582
Query: 590 KTIF-LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNC-PSQCNENPVDGHGL 647
T + L DIG V GT+CG +C + C+++ +++NC P+ CN+ + +
Sbjct: 583 STDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAFCNKRGICNNKH 640
Query: 648 QCHCEEGQAPVAC--------------EETLHVTNITILVVVLVLVIVGIGVLILLVRYR 693
CHC P C + L ++L++V+ ++L YR
Sbjct: 641 HCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVL----FILLCCLYR 696
Query: 694 KCIKLKQVQ 702
C K K ++
Sbjct: 697 LCKKSKPIK 705
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 314 bits (805), Expect = 2e-85
Identities = 198/669 (29%), Positives = 327/669 (48%), Gaps = 40/669 (5%)
Query: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETF-YSMKGEAFTRHPQIMDHCFYQGSIVHEY 117
L Y + + ++H+ + ++ L S + F Y+ +G P + ++C+Y G + +
Sbjct: 52 LSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDP 110
Query: 118 DSAASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPY----GANYSCTE 172
+S S+STC G +G +IND Y I+P+ +S EHLV+K + + + E
Sbjct: 111 ESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE 170
Query: 173 LNFTRKTVPGDNESEEDSKIKG--IHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230
+ + DN +++ S G IH + VE+ +V D+ +Y R +KL ++ +V
Sbjct: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHF-RIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229
Query: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVL 290
N V+ I + + V L G+EIWT+++ I + ++ ++ + W+ + + R D L
Sbjct: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHL 288
Query: 291 LSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC 350
+ L + GI GMC P+ S +I+ + + +AH LGHNLGM HDE C
Sbjct: 289 FTTLGLRG-LSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC 347
Query: 351 TCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKL 410
C +C+M +G+ P KFS CS + +Y + + C+L + + + CGN +
Sbjct: 348 RCSQPRCIMH-EGNPPITKFSNCSYGDFWEYTVE-RTKCLLETVHTKDIFNVKRCGNGVV 405
Query: 411 DEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFP 470
+EGEECDCGP + C C C L G TCA G CC+ C+ +G +CR +ECD P
Sbjct: 406 EEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLP 465
Query: 471 EMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYK-M 529
E C G S CP D + +G PCK GYC+ C R +QC +F A + + CYK +
Sbjct: 466 EWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKEL 524
Query: 530 NTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKC 589
NT G++ G+C K ++ C DV+CG+I C + + T H + N +
Sbjct: 525 NTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHW--ARFNDIMCW 582
Query: 590 KTIF-LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNC-PSQCNENPVDGHGL 647
T + L DIG V GT+CG +C + C+++ +++NC P+ CN+ + +
Sbjct: 583 STDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAFCNKRGICNNKH 640
Query: 648 QCHCEEGQAPVAC--------------EETLHVTNITILVVVLVLVIVGIGVLILLVRYR 693
CHC P C + L ++L++V+ ++L YR
Sbjct: 641 HCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVL----FILLCCLYR 696
Query: 694 KCIKLKQVQ 702
C K K ++
Sbjct: 697 LCKKSKPIK 705
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 314 bits (805), Expect = 2e-85
Identities = 198/669 (29%), Positives = 327/669 (48%), Gaps = 40/669 (5%)
Query: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETF-YSMKGEAFTRHPQIMDHCFYQGSIVHEY 117
L Y + + ++H+ + ++ L S + F Y+ +G P + ++C+Y G + +
Sbjct: 52 LSYILPFGGQKHIIHI-KVKKLLFSKHLPVFTYTDQGAILEDQPFVQNNCYYHGYVEGDP 110
Query: 118 DSAASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPY----GANYSCTE 172
+S S+STC G +G +IND Y I+P+ +S EHLV+K + + + E
Sbjct: 111 ESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFSTMRSGFMQNE 170
Query: 173 LNFTRKTVPGDNESEEDSKIKG--IHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230
+ + DN +++ S G IH + VE+ +V D+ +Y R +KL ++ +V
Sbjct: 171 ITCRMEFEEIDNSTQKQSSYVGWWIHF-RIVEIVVVIDNYLYIRYERNDSKLLEDLYVIV 229
Query: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVL 290
N V+ I + + V L G+EIWT+++ I + ++ ++ + W+ + + R D L
Sbjct: 230 NIVDSILDVIGVKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHL 288
Query: 291 LSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPC 350
+ L + GI GMC P+ S +I+ + + +AH LGHNLGM HDE C
Sbjct: 289 FTTLGLRG-LSGIGAFRGMCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTC 347
Query: 351 TCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKL 410
C +C+M +G+ P KFS CS + +Y + + C+L + + + CGN +
Sbjct: 348 RCSQPRCIMH-EGNPPITKFSNCSYGDFWEYTVE-RTKCLLETVHTKDIFNVKRCGNGVV 405
Query: 411 DEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFP 470
+EGEECDCGP + C C C L G TCA G CC+ C+ +G +CR +ECD P
Sbjct: 406 EEGEECDCGPLKHCAKDPCCLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLP 465
Query: 471 EMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICYK-M 529
E C G S CP D + +G PCK GYC+ C R +QC +F A + + CYK +
Sbjct: 466 EWCNGTSHKCPDDFYVEDGIPCK-ERGYCYEKSCHDRNEQCRRIFGAGANTASETCYKEL 524
Query: 530 NTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKC 589
NT G++ G+C K ++ C DV+CG+I C + + T H + N +
Sbjct: 525 NTLGDRVGHCGIKNATYIKCNISDVQCGRIQCENVTEIPNMSDHTTVHW--ARFNDIMCW 582
Query: 590 KTIF-LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNC-PSQCNENPVDGHGL 647
T + L DIG V GT+CG +C + C+++ +++NC P+ CN+ + +
Sbjct: 583 STDYHLGMKGPDIGEVKDGTECGIDHICIHRHCVHI--TILNSNCSPAFCNKRGICNNKH 640
Query: 648 QCHCEEGQAPVAC--------------EETLHVTNITILVVVLVLVIVGIGVLILLVRYR 693
CHC P C + L ++L++V+ ++L YR
Sbjct: 641 HCHCNYLWDPPNCLIKGYGGSVDSGPPPKRKKKKKFCYLCILLLIVL----FILLCCLYR 696
Query: 694 KCIKLKQVQ 702
C K K ++
Sbjct: 697 LCKKSKPIK 705
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 314 bits (805), Expect = 2e-85
Identities = 217/727 (29%), Positives = 341/727 (46%), Gaps = 37/727 (5%)
Query: 57 EELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHE 116
E L +++L+ + +L LL++RE + + +Y G +++C YQG +
Sbjct: 67 EPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGY 126
Query: 117 YDSAASISTCNGLRGFFRINDQR-YLIEPVKYSDEGEHLVFKY-NLRVP-YGANYSCTEL 173
S SI TC+GLRG + +R Y +E +G ++ + +L +P + S E
Sbjct: 127 AGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 174 NFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNF 232
T+K + + + E K VEL IVAD + ++ L NR +
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALL 245
Query: 233 VNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS 292
++ ++ LN+ V LVG+E WT D +E+ N TL F W+ L R D L++
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
Query: 293 GKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHD----EF 348
G G++ +C P +S + D +A+ +AH+LGH+LG+ HD
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
Query: 349 PCT--CPSGKCVMD-SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
PC P+ C+M+ S +P L FS CS+ + L D +C+ P FC
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFC 424
Query: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCA-EGECCESCQIKKAGSICRPAK 464
GN ++ GE+CDCG +C +PCCD+ TC L+PG CA +G CC++CQ++ +G CRP +
Sbjct: 425 GNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTR 484
Query: 465 DECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHD 524
+CD PE C G S CP D +G PC + C G+C + QC L+ A +
Sbjct: 485 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP 544
Query: 525 ICYK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQ 582
+C + NT+GN FG C +N ++ C +D CG++ C G LLG + +
Sbjct: 545 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID 604
Query: 583 KNAT-VKCKTIF--LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNE 639
N T + C + L D L GT CG G+VC + C ++ + + C S+C+
Sbjct: 605 VNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD-LLGAQECRSKCHG 663
Query: 640 NPVDGHGLQCHCEEGQAPVACEETLHVTN------ITILVVVLVLVIVGIGVLILLVRYR 693
+ V C+CEEG AP C L T+ + L+V+LVLV++G ++
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ 723
Query: 694 KCIKLK-------QVQSPPTETLGVENKGYF--GDEQQIRTEPILPEIHFLNKPA--SKD 742
+ +LK QS P+E G + G + ++ P P P S
Sbjct: 724 RLCQLKGPTCQYRAAQSGPSERPGPPQRALLARGTKAELADRPNPPTRPLPADPVVRSPK 783
Query: 743 SRGIADP 749
S+G A P
Sbjct: 784 SQGPAKP 790
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 313 bits (803), Expect = 3e-85
Identities = 208/684 (30%), Positives = 327/684 (47%), Gaps = 33/684 (4%)
Query: 57 EELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHE 116
E L +++L+ + +L LL++RE + + +Y G +++C YQG +
Sbjct: 67 EPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGY 126
Query: 117 YDSAASISTCNGLRGFFRINDQR-YLIEPVKYSDEGEHLVFKY-NLRVP-YGANYSCTEL 173
S SI TC+GLRG + +R Y +E +G ++ + +L +P + S E
Sbjct: 127 AGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 174 NFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNF 232
T+K + + + E K VEL IVAD + ++ L NR +
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALL 245
Query: 233 VNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS 292
++ ++ LN+ V LVG+E WT D +E+ N TL F W+ L R D L++
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
Query: 293 GKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHD----EF 348
G G++ +C P +S + D +A+ +AH+LGH+LG+ HD
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
Query: 349 PCT--CPSGKCVMD-SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
PC P+ C+M+ S +P L FS CS+ + L D +C+ P FC
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFC 424
Query: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCA-EGECCESCQIKKAGSICRPAK 464
GN ++ GE+CDCG +C +PCCD+ TC L+PG CA +G CC++CQ++ +G CRP +
Sbjct: 425 GNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTR 484
Query: 465 DECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHD 524
+CD PE C G S CP D +G PC + C G+C + QC L+ A +
Sbjct: 485 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP 544
Query: 525 ICYK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQ 582
+C + NT+GN FG C +N ++ C +D CG++ C G LLG + +
Sbjct: 545 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID 604
Query: 583 KNAT-VKCKTIF--LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNE 639
N T + C + L D L GT CG G+VC + C ++ + + C S+C+
Sbjct: 605 VNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD-LLGAQECRSKCHG 663
Query: 640 NPVDGHGLQCHCEEGQAPVACEETLHVTN------ITILVVVLVLVIVGIGVLILLVRYR 693
+ V C+CEEG AP C L T+ + L+V+LVLV++G ++
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ 723
Query: 694 KCIKLK-------QVQSPPTETLG 710
+ +LK QS P+E G
Sbjct: 724 RLCQLKGPTCQYRAAQSGPSERPG 747
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 313 bits (803), Expect = 3e-85
Identities = 208/684 (30%), Positives = 327/684 (47%), Gaps = 33/684 (4%)
Query: 57 EELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHE 116
E L +++L+ + +L LL++RE + + +Y G +++C YQG +
Sbjct: 67 EPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGY 126
Query: 117 YDSAASISTCNGLRGFFRINDQR-YLIEPVKYSDEGEHLVFKY-NLRVP-YGANYSCTEL 173
S SI TC+GLRG + +R Y +E +G ++ + +L +P + S E
Sbjct: 127 AGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 174 NFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNF 232
T+K + + + E K VEL IVAD + ++ L NR +
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALL 245
Query: 233 VNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS 292
++ ++ LN+ V LVG+E WT D +E+ N TL F W+ L R D L++
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
Query: 293 GKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHD----EF 348
G G++ +C P +S + D +A+ +AH+LGH+LG+ HD
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
Query: 349 PCT--CPSGKCVMD-SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
PC P+ C+M+ S +P L FS CS+ + L D +C+ P FC
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFC 424
Query: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCA-EGECCESCQIKKAGSICRPAK 464
GN ++ GE+CDCG +C +PCCD+ TC L+PG CA +G CC++CQ++ +G CRP +
Sbjct: 425 GNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTR 484
Query: 465 DECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHD 524
+CD PE C G S CP D +G PC + C G+C + QC L+ A +
Sbjct: 485 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP 544
Query: 525 ICYK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQ 582
+C + NT+GN FG C +N ++ C +D CG++ C G LLG + +
Sbjct: 545 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID 604
Query: 583 KNAT-VKCKTIF--LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNE 639
N T + C + L D L GT CG G+VC + C ++ + + C S+C+
Sbjct: 605 VNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD-LLGAQECRSKCHG 663
Query: 640 NPVDGHGLQCHCEEGQAPVACEETLHVTN------ITILVVVLVLVIVGIGVLILLVRYR 693
+ V C+CEEG AP C L T+ + L+V+LVLV++G ++
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ 723
Query: 694 KCIKLK-------QVQSPPTETLG 710
+ +LK QS P+E G
Sbjct: 724 RLCQLKGPTCQYRAAQSGPSERPG 747
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 313 bits (803), Expect = 3e-85
Identities = 208/684 (30%), Positives = 327/684 (47%), Gaps = 33/684 (4%)
Query: 57 EELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHE 116
E L +++L+ + +L LL++RE + + +Y G +++C YQG +
Sbjct: 67 EPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGY 126
Query: 117 YDSAASISTCNGLRGFFRINDQR-YLIEPVKYSDEGEHLVFKY-NLRVP-YGANYSCTEL 173
S SI TC+GLRG + +R Y +E +G ++ + +L +P + S E
Sbjct: 127 AGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 174 NFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNF 232
T+K + + + E K VEL IVAD + ++ L NR +
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALL 245
Query: 233 VNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS 292
++ ++ LN+ V LVG+E WT D +E+ N TL F W+ L R D L++
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
Query: 293 GKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHD----EF 348
G G++ +C P +S + D +A+ +AH+LGH+LG+ HD
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
Query: 349 PCT--CPSGKCVMD-SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
PC P+ C+M+ S +P L FS CS+ + L D +C+ P FC
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFC 424
Query: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCA-EGECCESCQIKKAGSICRPAK 464
GN ++ GE+CDCG +C +PCCD+ TC L+PG CA +G CC++CQ++ +G CRP +
Sbjct: 425 GNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTR 484
Query: 465 DECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHD 524
+CD PE C G S CP D +G PC + C G+C + QC L+ A +
Sbjct: 485 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP 544
Query: 525 ICYK-MNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQ 582
+C + NT+GN FG C +N ++ C +D CG++ C G LLG + +
Sbjct: 545 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID 604
Query: 583 KNAT-VKCKTIF--LYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNE 639
N T + C + L D L GT CG G+VC + C ++ + + C S+C+
Sbjct: 605 VNGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVD-LLGAQECRSKCHG 663
Query: 640 NPVDGHGLQCHCEEGQAPVACEETLHVTN------ITILVVVLVLVIVGIGVLILLVRYR 693
+ V C+CEEG AP C L T+ + L+V+LVLV++G ++
Sbjct: 664 HGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLGASYWYRARLHQ 723
Query: 694 KCIKLK-------QVQSPPTETLG 710
+ +LK QS P+E G
Sbjct: 724 RLCQLKGPTCQYRAAQSGPSERPG 747
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 312 bits (800), Expect = 6e-85
Identities = 202/650 (31%), Positives = 317/650 (48%), Gaps = 28/650 (4%)
Query: 57 EELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHE 116
E L +++L+ + +L LL++RE + + +Y G +++C YQG +
Sbjct: 67 EPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGY 126
Query: 117 YDSAASISTCNGLRGFFRINDQR-YLIEPVKYSDEGEHLVFKY-NLRVP-YGANYSCTEL 173
S SI TC+GLRG + +R Y +E +G ++ + +L +P + S E
Sbjct: 127 AGSWVSICTCSGLRGLVVLTPERSYTLEQGPGDLQGPPIISRIQDLHLPGHTCALSWRES 186
Query: 174 NFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNF 232
T+K + + + E K VEL IVAD + ++ L NR +
Sbjct: 187 VHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKY-RDFQHLLNRTLEVALL 245
Query: 233 VNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS 292
++ ++ LN+ V LVG+E WT D +E+ N TL F W+ L R D L++
Sbjct: 246 LDTFFRPLNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQLVT 305
Query: 293 GKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHD----EF 348
G G++ +C P +S + D +A+ +AH+LGH+LG+ HD
Sbjct: 306 GTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDLPGNSC 365
Query: 349 PCT--CPSGKCVMD-SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFC 405
PC P+ C+M+ S +P L FS CS+ + L D +C+ P FC
Sbjct: 366 PCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFE-RLPSLPPMAAFC 424
Query: 406 GNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCA-EGECCESCQIKKAGSICRPAK 464
GN ++ GE+CDCG +C +PCCD+ TC L+PG CA +G CC++CQ++ +G CRP +
Sbjct: 425 GNMFVEPGEQCDCGFLDDCVDPCCDSLTCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTR 484
Query: 465 DECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHD 524
+CD PE C G S CP D +G PC + C G+C + QC L+ A +
Sbjct: 485 GDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAP 544
Query: 525 ICYKM-NTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQ 582
+C + NT+GN FG C +N ++ C +D CG++ C G LLG + +
Sbjct: 545 LCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSIRDLLWETID 604
Query: 583 KNAT-VKCKTIFLYHDSTDIG---LVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCN 638
N T + C + L S D+ L GT CG G+VC + C ++ + + C S+C+
Sbjct: 605 VNGTELNCSWVHLDLGS-DVAQPLLTLPGTACGPGLVCIDHRCQRVDLLG-AQECRSKCH 662
Query: 639 ENPVDGHGLQCHCEEGQAPVACEETLHVTN------ITILVVVLVLVIVG 682
+ V C+CEEG AP C L T+ + L+V+LVLV++G
Sbjct: 663 GHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLSLLVLLVLVMLG 712
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 302 bits (774), Expect = 7e-82
Identities = 185/620 (29%), Positives = 293/620 (47%), Gaps = 31/620 (5%)
Query: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYD 118
L Y ++ + ++H+ ++ ++ Y+ + P I D C+Y G + +
Sbjct: 111 LSYSLRFGGQRYIVHMRVNKLLFAAHLPVFTYTEQHALLQDQPFIQDDCYYHGYVEGVPE 170
Query: 119 SAASISTCNG-LRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTR 177
S ++STC+G G +IND Y I+P+ S EHLV+K + C T
Sbjct: 171 SLVALSTCSGGFLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRC---GLTE 227
Query: 178 KTVPGDNESE--------EDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGM 229
+ + E + + S + +++VEL +V D+ Y + +++ ++ +
Sbjct: 228 EKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDNIRYLFSQSNATTVQHEVFNV 287
Query: 230 VNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVV 289
VN V+ Y L + V L GI+IWT + + +++ L FS W+ L R D V
Sbjct: 288 VNIVDSFYHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHD-VA 346
Query: 290 LLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNII--ANRMAHQLGHNLGMQHDE 347
L K G++Y G+C ++T + D+ D ++ A + H+LGHNLGMQHD
Sbjct: 347 HLFIKDTQGMKLGVAYVKGICQNPFNTGV--DVFEDNRLVVFAITLGHELGHNLGMQHDT 404
Query: 348 FPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGN 407
C C C+M + + KFS CS QY C+ P+P N ++CGN
Sbjct: 405 QWCVCELQWCIMHAYRKVTT-KFSNCSYAQYWDSTIS-SGLCIQPPPYPGNIFRLKYCGN 462
Query: 408 KKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDEC 467
++EGEECDCG ++C C C L PG CA G CC+ C+ +G++CR EC
Sbjct: 463 LVVEEGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGEC 522
Query: 468 DFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICY 527
D PE C G S CP D + +G C N +C+ C + QC E+F +A + CY
Sbjct: 523 DLPEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCY 581
Query: 528 -KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTG-GELSSLLGED--KTYHLKDPQK 583
++NT+GN+FG+C ++ C D+ CG++ C G + +L+ + +HL D
Sbjct: 582 QEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHLND--- 638
Query: 584 NATVKCKTIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNC-PSQCNENPV 642
T L DIG V GT CG +C +C +M V++S C P CN +
Sbjct: 639 -TTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASM--VHLSQACQPKTCNMRGI 695
Query: 643 DGHGLQCHCEEGQAPVACEE 662
+ CHC AP C++
Sbjct: 696 CNNKQHCHCNHEWAPPYCKD 715
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 298 bits (763), Expect = 1e-80
Identities = 198/667 (29%), Positives = 320/667 (47%), Gaps = 35/667 (5%)
Query: 59 LLYEIKLNRKTLVLHLLRSREFLGSNYSETF-YSMKGEAFTRHPQIMDHCFYQGSIVHEY 117
L Y ++ + V+H+ R ++ L S + F Y+ + I D C+Y G +
Sbjct: 61 LSYSLRFGGQKHVVHM-RVKKLLVSRHLPVFTYTDERALLEDQLFIPDDCYYHGYVEGAP 119
Query: 118 DSAASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSC--TELN 174
+S S C G RG +I+ Y IEP+++S EHLV+K N C TE
Sbjct: 120 ESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKE 179
Query: 175 FTRKTVPGDNESEEDSKIKGIHD----EKYVELFIVADDTVYRRNGHPHNKLRNRIWGMV 230
R+ + + + K D ++EL +V + + + +K++ ++ +V
Sbjct: 180 VARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVV 239
Query: 231 NFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQE-KILKTRKDFDHVV 289
N V+ +Y+ L ++ L+GIEIW + + S IE L FS W++ + + + D H+
Sbjct: 240 NIVDSMYQQLGTYIILIGIEIWNQGNVFPMTS-IEQVLNDFSQWKQISLSQLQHDAAHMF 298
Query: 290 LLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFP 349
+ + + G++Y G+C P + ++ AN +AH+LGH LGMQHDE
Sbjct: 299 IKNS---LISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEF 355
Query: 350 CTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDY--KPTCMLNIPFPYNFHDFQFCGN 407
C C C+M++ +PA KF+ CS Y ++K + +C+ N P + CGN
Sbjct: 356 CFCGERGCIMNTF-RVPAEKFTNCS---YADFMKTTLNQGSCLHNPPRLGEIFMLKRCGN 411
Query: 408 KKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDEC 467
++ E+CDCG Q+C C C L+PG CA G CC+ C+ +G +CR +EC
Sbjct: 412 GVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEVNEC 471
Query: 468 DFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICY 527
D PE C G S CP+D++ +G PC +S YC+ +C + C E+F +A + CY
Sbjct: 472 DLPEWCNGTSHQCPEDRYVQDGIPCSDS-AYCYQKRCNNHDQHCREIFGKDAKSASQNCY 530
Query: 528 K-MNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNAT 586
K +N++GN+FG+C +L C DV CG++ C LL + T L+ N
Sbjct: 531 KEINSQGNRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFT--LQHTHING- 587
Query: 587 VKCKTI--FLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVDG 644
V C I L + +DIG V GT CG G +C + +C+++ V P CN +
Sbjct: 588 VTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSL-SVLSHVCLPETCNMKGICN 646
Query: 645 HGLQCHCEEGQAPVACEETLHVTNITI-------LVVVLVLVIVGIGVLILLVRYRKCIK 697
+ CHC G +P C+ + +I V + ++VI + VL L +
Sbjct: 647 NKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSVLTFLFTVGLLMY 706
Query: 698 LKQVQSP 704
L+Q P
Sbjct: 707 LRQCSGP 713
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 295 bits (754), Expect = 1e-79
Identities = 202/619 (32%), Positives = 302/619 (48%), Gaps = 36/619 (5%)
Query: 61 YEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSA 120
Y ++L K VLHL R L + ++ GE HP I C Y GS+ DS
Sbjct: 64 YLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSK 123
Query: 121 ASISTC-NGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSC--TELNFTR 177
A+ISTC GLRG F I+ + Y IEP+K S EH+V Y L+ N C ++
Sbjct: 124 ATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVV--YLLKKEQFGNQVCGLSDDEIEW 181
Query: 178 KTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIY 237
+ P +N++ KY+EL ++ D + YR + +++ + + ++ +
Sbjct: 182 QMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYF 241
Query: 238 KTLNIHVTLVGIEIWTHEDKIEL-YSNIETTLLRFSFWQEKILKTR--KDFDHVVLLSGK 294
+ + + + L +E+WT +KI + Y + L RF +++ +L R D+ H+ L +
Sbjct: 242 QDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYL---Q 298
Query: 295 WLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRM--AHQLGHNLGMQHDEFPCTC 352
Y+ S+ G +C Y+ S+ L DTNI+A AH+LGH +GM HDE C C
Sbjct: 299 RKYNDALAWSF-GKVCSLEYAGSV--STLLDTNILAPATWSAHELGHAVGMSHDEQYCQC 355
Query: 353 PSG-KCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLD 411
C+M S + FS CS + +++ TC+ NIP + + CGNK ++
Sbjct: 356 RGRLNCIMGSGRT----GFSNCSYISFFKHISS-GATCLNNIPGLG--YVLKRCGNKIVE 408
Query: 412 EGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPE 471
+ EECDCG +EC C C L+PG C+ G CC C+ + +G +CR +ECD E
Sbjct: 409 DNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAE 468
Query: 472 MCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIESHDICY-KMN 530
C G+S +CP D ++ +G PCK EG CF C +R QC +F +A+E+ CY +N
Sbjct: 469 YCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVN 527
Query: 531 TKGNKFGYCKNKENR-FLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKDPQKNATVKC 589
G++FG C+ R F CE + CG++ C E L E T Q +
Sbjct: 528 LIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCW 587
Query: 590 KTIFLYHDS------TDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNENPVD 643
T YH S D+G++ GT CGEG VC C+N + P +CN V
Sbjct: 588 GT--GYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDC-LPEKCNTRGVC 644
Query: 644 GHGLQCHCEEGQAPVACEE 662
+ CHC G AP CEE
Sbjct: 645 NNRKNCHCMYGWAPPFCEE 663
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 293 bits (751), Expect = 3e-79
Identities = 200/649 (30%), Positives = 312/649 (48%), Gaps = 64/649 (9%)
Query: 61 YEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSA 120
++I+ +L L+ + L S+Y E Y +++ + HC+Y GSI DS
Sbjct: 153 FQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGE---HCYYHGSIRGVKDSK 209
Query: 121 ASISTCNGLRGFFRINDQRYLIEPVKYSDEGE-----HLVFKY----------NLRVPYG 165
++STCNGL G F + Y+IEP++ + + H++ K NL + G
Sbjct: 210 VALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERG 269
Query: 166 ANYS-CTELNFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNKLR 223
+ +EL + ++ N S +GI +E KY+EL IV D Y+++ H
Sbjct: 270 DQWPFLSELQWLKRRKRAVNPS------RGIFEEMKYLELMIVNDHKTYKKHRSSHAHTN 323
Query: 224 NRIWGMVNFVNMIYKT-LNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTR 282
N +VN V+ IYK LN V LV +E WT +D+I++ +N L FS ++++I +
Sbjct: 324 NFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRI---K 380
Query: 283 KDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLG 342
+ D V L+S + +SY GG+C + + LP +A ++ L NLG
Sbjct: 381 QHADAVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMA--VAQVLSQSLAQNLG 438
Query: 343 MQHD------EFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFP 396
+Q + + CT G C+M+ G + KFSKCS +Y +L+ C+ N P
Sbjct: 439 IQWEPSSRKPKCDCTESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPT- 497
Query: 397 YNFHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCE--SCQIK 454
+ CGN ++ GEECDCG EC CC C L G C++G CC SC +
Sbjct: 498 -KLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHCSDGPCCNNTSCLFQ 554
Query: 455 KAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSEL 514
G CR A +ECD E CTG S CP + + +G+ C ++G C+ G+C TR++QC +
Sbjct: 555 PRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYI 614
Query: 515 FDDEAIESHDICY-KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTG-------GEL 566
+ +A S CY K+NT+G + G C +R++ C + DV CG + CT G+L
Sbjct: 615 WGTKAAGSDKFCYEKLNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQL 674
Query: 567 SSLLGEDKTYHLKDPQKNATVKCK-TIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNME 625
+ YH + + C + D TD+G V GT CG M+C + +CL ++
Sbjct: 675 QGEIIPTSFYH-----QGRVIDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQ 729
Query: 626 KVYISTNCPSQCNENPVDGHGL-----QCHCEEGQAPVACEETLHVTNI 669
+ +S +CP GHG+ C C+ A C V N+
Sbjct: 730 ALNMS-SCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNL 777
>gi|7657319 ADAM-like, decysin 1 isoform 1 [Homo sapiens]
Length = 470
Score = 287 bits (735), Expect = 2e-77
Identities = 157/420 (37%), Positives = 238/420 (56%), Gaps = 7/420 (1%)
Query: 28 QLVRPKKLPLIQKRD--TGHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGSNY 85
++V PKKL ++ KR+ T + YE E+ Y++ LN + ++L L +++ LG +Y
Sbjct: 43 EIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDY 102
Query: 86 SETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPV 145
+ET YS +GE T P+ M+HC+Y+G+I++E +S ASISTC+GLRG+F + QRY I+P+
Sbjct: 103 TETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPL 162
Query: 146 KYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVP--GDNESEEDSKIKGIHDEKYVEL 203
K +DE EH VF N AN++C + K P + K + +KY++L
Sbjct: 163 KSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDL 222
Query: 204 FIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSN 263
++V D+ Y+ +R+ ++ ++N +N+IY T+++ V LVG+EIW+ DKI++ +
Sbjct: 223 YLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPS 282
Query: 264 IETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLL 323
TT F W L +K DH LLSG + G++ +C P S ++I+
Sbjct: 283 ASTTFDNFLRWHSSNL-GKKIHDHAQLLSGISFNNRRVGLAASNSLCSP-SSVAVIEAKK 340
Query: 324 PDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSDGSIPALK-FSKCSQNQYHQYL 382
+ + M+H+LGH LGM F CPSG CVM+ S K FS + + +YL
Sbjct: 341 KNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYL 400
Query: 383 KDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTC 442
KP C+L P P N CGN L+ GE+CDCG +ECTN CC+A TC LKPG C
Sbjct: 401 LSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDC 460
>gi|7656861 a disintegrin and metalloprotease domain 18
preproprotein [Homo sapiens]
Length = 739
Score = 281 bits (719), Expect = 2e-75
Identities = 182/622 (29%), Positives = 295/622 (47%), Gaps = 25/622 (4%)
Query: 56 EEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVH 115
E +++Y I ++ + LHL + + FL N+ Y+ G + P M HC YQG
Sbjct: 42 ERKMIYIITIDGQPYTLHLGK-QSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAE 100
Query: 116 EYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVP----YGANYSCT 171
+S ++S C+GLRGF + + Y IEPV+ S EH++++ P NYS
Sbjct: 101 FPNSFVTLSICSGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHI 160
Query: 172 ELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVN 231
VP +++ + SK+ +Y+E++I+ + +Y G + +I ++
Sbjct: 161 WQKDQPYKVPLNSQIKNLSKLL----PQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIG 216
Query: 232 FVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLL 291
VN ++ + V L +E+W++E++I + + L RF W+ L R +L+
Sbjct: 217 LVNTMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYLILRPHDIAYLLV 276
Query: 292 SGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANR---MAHQLGHNLGMQHDEF 348
K + G ++PG +C Y I + PD + +A LG N+G+ +D+
Sbjct: 277 YRK--HPKYVGATFPGTVCNKSYDAGIA--MYPDAIGLEGFSVIIAQLLGLNVGLTYDDI 332
Query: 349 P-CTCPSGKCVMDSDGSIPALK--FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQ-F 404
C C C+M+ + + + FS CS + Y ++ ++ C+ + H Q
Sbjct: 333 TQCFCLRATCIMNHEAVSASGRKIFSNCSMHDYRYFVSKFETKCLQKLSNLQPLHQNQPV 392
Query: 405 CGNKKLDEGEECDCGPAQECT-NPCCDAHTCVLKPGFTCAEGECCES-CQIKKAGSICRP 462
CGN L+ EECDCG EC CCD +TC LK C G CC S C++ AG+ CR
Sbjct: 393 CGNGILESNEECDCGNKNECQFKKCCDYNTCKLKGSVKCGSGPCCTSKCELSIAGTPCRK 452
Query: 463 AKD-ECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDEAIE 521
+ D ECDF E C G S C D + +NG CK YC+ G+C T ++QC+++F A
Sbjct: 453 SIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQCAKIFGKGAQG 512
Query: 522 SHDICYK-MNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDKTYHLKD 580
+ C+K +N+ + C K ++ LPCE KDV CGK+ C ++ + ++
Sbjct: 513 APFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQSTVYSY 572
Query: 581 PQKNATVKCKT-IFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPSQCNE 639
Q + V T + D TD VA GT CG M C N C + + + N ++C
Sbjct: 573 IQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMGYNCNATTKCKG 632
Query: 640 NPVDGHGLQCHCEEGQAPVACE 661
+ + C C G P C+
Sbjct: 633 KGICNNFGNCQCFPGHRPPDCK 654
>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
sapiens]
Length = 787
Score = 273 bits (697), Expect = 6e-73
Identities = 187/651 (28%), Positives = 303/651 (46%), Gaps = 40/651 (6%)
Query: 28 QLVRPKKLPLIQKRDTGHTHDDDILKTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSE 87
Q+V P+K+ T+ +D + E++ Y I ++ K +HL + R FL N+
Sbjct: 27 QIVIPEKI---------QTNTNDSSEIEYEQISYIIPIDEKLYTVHL-KQRYFLADNFMI 76
Query: 88 TFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKY 147
Y+ +G T I C+YQG+I DS ++STC+GLRG + + Y IEP++
Sbjct: 77 YLYN-QGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLES 135
Query: 148 SDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVPGDNE---SEEDSKIKGIHDEKYVELF 204
+ E +H+++K N ++ + K P D+ SE+ Y+E+
Sbjct: 136 AVEFQHVLYKLKNE----DNDIAIFIDRSLKEQPMDDNIFISEKSEPAVPDLFPLYLEMH 191
Query: 205 IVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNI 264
IV D T+Y G + N++ +V N ++ + + L +E+W+ E+KI
Sbjct: 192 IVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEA 251
Query: 265 ETTLLRFSFWQEKILKTRK-DFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLL 323
+ L +F W++ L R D ++++ Y G +PG MC+ YS + L
Sbjct: 252 DELLQKFLEWKQSYLNLRPHDIAYLLIYMD---YPRYLGAVFPGTMCITRYSAGVA--LY 306
Query: 324 PDT---NIIANRMAHQLGHNLGMQHDE-FPCTCPSGKCVMDSD--GSIPALKFSKCSQNQ 377
P A + L +LG+ +D+ C C C+M+ + S FS CS
Sbjct: 307 PKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNGVKTFSSCSLRS 366
Query: 378 YHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQEC-TNPCCDAHTCVL 436
+ ++ + C+ N P CGN +L+ E CDCG +C CCD TCVL
Sbjct: 367 FQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCDFRTCVL 426
Query: 437 KPGFTCAEGECCESCQIKKAGSICRP-AKDECDFPEMCTGHSPACPKDQFRVNGFPCKNS 495
K G C +G CC+ CQI ++G CRP A ECD E C G SP C D +NG CKN+
Sbjct: 427 KDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNN 486
Query: 496 EGYCFMGKCPTREDQCSELFDDEAIESHDICY-KMNTKGNKFGYC-KNKENRFLPCEEKD 553
+ C+ G C + +C +F + + CY ++ ++ ++FG C +++ N+++ C ++
Sbjct: 487 KFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRN 546
Query: 554 VRCGKIYCTGGELSSLLGE--DKTYHLKDPQKNATVKCKTIFLYHDSTDIGLVASGTKCG 611
+ CG++ CT E D Y TV K L D V +G++C
Sbjct: 547 LICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYK---LPRTVPDPLAVKNGSQCD 603
Query: 612 EGMVCNNGECLNMEKVYISTN-CPSQCNENPVDGHGLQCHCEEGQAPVACE 661
G VC N EC+ + S + C QC+ + V +CHC G P C+
Sbjct: 604 IGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQ 654
>gi|223671932 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
Length = 391
Score = 270 bits (690), Expect = 4e-72
Identities = 145/381 (38%), Positives = 217/381 (56%), Gaps = 5/381 (1%)
Query: 65 LNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASIS 124
LN + ++L L +++ LG +Y+ET YS +GE T P+ M+HC+Y+G+I++E +S ASIS
Sbjct: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
Query: 125 TCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVP--G 182
TC+GLRG+F + QRY I+P+K +DE EH VF N AN++C + K P
Sbjct: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRI 122
Query: 183 DNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNI 242
+ K + +KY++L++V D+ Y+ +R+ ++ ++N +N+IY T+++
Sbjct: 123 SRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDV 182
Query: 243 HVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQG 302
V LVG+EIW+ DKI++ + TT F W L +K DH LLSG + G
Sbjct: 183 QVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNL-GKKIHDHAQLLSGISFNNRRVG 241
Query: 303 ISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSD 362
++ +C P S ++I+ + + M+H+LGH LGM F CPSG CVM+
Sbjct: 242 LAASNSLCSP-SSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
Query: 363 GSIPALK-FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPA 421
S K FS + + +YL KP C+L P P N CGN L+ GE+CDCG
Sbjct: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
Query: 422 QECTNPCCDAHTCVLKPGFTC 442
+ECTN CC+A TC LKPG C
Sbjct: 361 KECTNLCCEALTCKLKPGTDC 381
>gi|223671930 ADAM-like, decysin 1 isoform 2 [Homo sapiens]
Length = 391
Score = 270 bits (690), Expect = 4e-72
Identities = 145/381 (38%), Positives = 217/381 (56%), Gaps = 5/381 (1%)
Query: 65 LNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASIS 124
LN + ++L L +++ LG +Y+ET YS +GE T P+ M+HC+Y+G+I++E +S ASIS
Sbjct: 3 LNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASIS 62
Query: 125 TCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKYNLRVPYGANYSCTELNFTRKTVP--G 182
TC+GLRG+F + QRY I+P+K +DE EH VF N AN++C + K P
Sbjct: 63 TCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRI 122
Query: 183 DNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNRIWGMVNFVNMIYKTLNI 242
+ K + +KY++L++V D+ Y+ +R+ ++ ++N +N+IY T+++
Sbjct: 123 SRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDV 182
Query: 243 HVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLSGKWLYSHVQG 302
V LVG+EIW+ DKI++ + TT F W L +K DH LLSG + G
Sbjct: 183 QVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNL-GKKIHDHAQLLSGISFNNRRVG 241
Query: 303 ISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQHDEFPCTCPSGKCVMDSD 362
++ +C P S ++I+ + + M+H+LGH LGM F CPSG CVM+
Sbjct: 242 LAASNSLCSP-SSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQY 300
Query: 363 GSIPALK-FSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPA 421
S K FS + + +YL KP C+L P P N CGN L+ GE+CDCG
Sbjct: 301 LSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSP 360
Query: 422 QECTNPCCDAHTCVLKPGFTC 442
+ECTN CC+A TC LKPG C
Sbjct: 361 KECTNLCCEALTCKLKPGTDC 381
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 267 bits (683), Expect = 2e-71
Identities = 182/633 (28%), Positives = 294/633 (46%), Gaps = 49/633 (7%)
Query: 54 TYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSI 113
T+ ++ +++ + +L ++ + + L S Y E G+ T + +HC+YQG I
Sbjct: 84 THVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGK--TVEVKGGEHCYYQGHI 141
Query: 114 VHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGE----HLVFKYNL------RVP 163
DS ++STC+GL G F + YLIEP + E H V+K L +P
Sbjct: 142 RGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201
Query: 164 YG-ANYSCTELNFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNK 221
+ T F K P ++ + + + +E KY+EL IV D +++++
Sbjct: 202 SEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVH 261
Query: 222 LRNRIWGMVNFVNMIYKT-LNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILK 280
+VN ++IYK L + LV +E W ++K + N TL F ++ +K
Sbjct: 262 TNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIK 321
Query: 281 TRKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIK----DLLPDTNIIANRMAHQ 336
+ D H L SG S G +Y GG+C S++K + T+++A +A
Sbjct: 322 EKSDAVH--LFSGSQFESSRSGAAYIGGIC------SLLKGGGVNEFGKTDLMAVTLAQS 373
Query: 337 LGHNLGMQHD-------EFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTC 389
L HN+G+ D E C C+M G KF++C+ +YH +L C
Sbjct: 374 LAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGAC 433
Query: 390 MLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECT---NPCCDAHTCVLKPGFTCAEGE 446
+ N P D CGN ++ GEECDCG EC CC C L C++G
Sbjct: 434 LFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCSDGL 489
Query: 447 CCESCQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPT 506
CC+ C+ + G++CR A ++CD E C+G+S C + +++G+ C +G CF G+C T
Sbjct: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549
Query: 507 REDQCSELFDDEAIESHDICY-KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGE 565
R+ QC ++ + S CY K+N +G + G C ++ ++ C ++DV CG + CT
Sbjct: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIG 609
Query: 566 LSSLLGE--DKTYHLKDPQKNATVKCKTIFL-YHDSTDIGLVASGTKCGEGMVCNNGECL 622
LGE + Q+ T+ C + + D+G V GT CG M+C CL
Sbjct: 610 NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCL 669
Query: 623 NMEKVYISTNCPSQ----CNENPVDGHGLQCHC 651
+ ST S+ C+ N V + L+C C
Sbjct: 670 PVASFNFSTCLSSKEGTICSGNGVCSNELKCVC 702
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.139 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,623,076
Number of Sequences: 37866
Number of extensions: 1668137
Number of successful extensions: 4375
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 3517
Number of HSP's gapped (non-prelim): 656
length of query: 754
length of database: 18,247,518
effective HSP length: 110
effective length of query: 644
effective length of database: 14,082,258
effective search space: 9068974152
effective search space used: 9068974152
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.