Guide to the Human Genome
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Search of human proteins with 21536386

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21536386 ADAM metallopeptidase domain 22 isoform 2
preproprotein [Homo sapiens]
         (899 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...  1888   0.0  
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...  1807   0.0  
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...  1789   0.0  
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...  1728   0.0  
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...  1710   0.0  
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s...   853   0.0  
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...   754   0.0  
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   371   e-102
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   370   e-102
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   366   e-101
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   328   1e-89
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   327   2e-89
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   313   6e-85
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   313   6e-85
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   313   6e-85
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   313   6e-85
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...   313   6e-85
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   313   6e-85
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot...   310   3e-84
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   307   3e-83
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   290   5e-78
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ...   281   1e-75
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...   277   3e-74
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...   267   3e-71
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...   258   1e-68
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...   258   1e-68
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...   258   1e-68
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...   258   1e-68
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi...   253   6e-67
gi|148664238 a disintegrin and metalloprotease domain 32 [Homo s...   252   1e-66

>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score = 1888 bits (4891), Expect = 0.0
 Identities = 899/899 (100%), Positives = 899/899 (100%)

Query: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
           MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60

Query: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
           GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120

Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
           EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180

Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
           DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240

Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
           IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300

Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
           ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360

Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
           GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420

Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
           EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480

Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
           QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540

Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
           ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600

Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
           GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660

Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
           MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720

Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIP 780
           AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIP
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIP 780

Query: 781 DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYLNPWFKRDYNVAKWVE 840
           DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYLNPWFKRDYNVAKWVE
Sbjct: 781 DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYLNPWFKRDYNVAKWVE 840

Query: 841 DVNKNTEGPYFRTLSPAKSPSSSTGSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI 899
           DVNKNTEGPYFRTLSPAKSPSSSTGSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI
Sbjct: 841 DVNKNTEGPYFRTLSPAKSPSSSTGSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI 899


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score = 1807 bits (4680), Expect = 0.0
 Identities = 870/899 (96%), Positives = 870/899 (96%), Gaps = 29/899 (3%)

Query: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
           MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60

Query: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
           GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120

Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
           EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180

Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
           DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240

Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
           IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300

Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
           ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360

Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
           GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420

Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
           EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480

Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
           QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540

Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
           ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600

Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
           GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660

Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
           MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720

Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIP 780
           AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIP
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIP 780

Query: 781 DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEYLNPWFKRDYNVAKWVE 840
           DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTE                 
Sbjct: 781 DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTE----------------- 823

Query: 841 DVNKNTEGPYFRTLSPAKSPSSSTGSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI 899
                       TLSPAKSPSSSTGSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI
Sbjct: 824 ------------TLSPAKSPSSSTGSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI 870


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score = 1789 bits (4633), Expect = 0.0
 Identities = 870/935 (93%), Positives = 870/935 (93%), Gaps = 65/935 (6%)

Query: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
           MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60

Query: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
           GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120

Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
           EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180

Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
           DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240

Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
           IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300

Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
           ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360

Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
           GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420

Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
           EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480

Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
           QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540

Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
           ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600

Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
           GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660

Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
           MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720

Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ-------------- 766
           AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ              
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD 780

Query: 767 ----------------------RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 804
                                 RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG
Sbjct: 781 GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 840

Query: 805 GNKKKIRGKRFRPRSNSTEYLNPWFKRDYNVAKWVEDVNKNTEGPYFRTLSPAKSPSSST 864
           GNKKKIRGKRFRPRSNSTE                             TLSPAKSPSSST
Sbjct: 841 GNKKKIRGKRFRPRSNSTE-----------------------------TLSPAKSPSSST 871

Query: 865 GSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI 899
           GSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI
Sbjct: 872 GSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI 906


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score = 1728 bits (4476), Expect = 0.0
 Identities = 823/823 (100%), Positives = 823/823 (100%)

Query: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
           MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60

Query: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
           GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120

Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
           EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180

Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
           DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240

Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
           IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300

Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
           ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360

Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
           GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420

Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
           EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480

Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
           QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540

Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
           ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600

Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
           GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660

Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
           MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720

Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIP 780
           AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIP
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHSWSERIP 780

Query: 781 DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTE 823
           DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTE
Sbjct: 781 DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTE 823


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score = 1710 bits (4429), Expect = 0.0
 Identities = 823/859 (95%), Positives = 823/859 (95%), Gaps = 36/859 (4%)

Query: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60
           MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG
Sbjct: 1   MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSG 60

Query: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120
           GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI
Sbjct: 61  GEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHI 120

Query: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180
           EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE
Sbjct: 121 EHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQE 180

Query: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240
           DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY
Sbjct: 181 DFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKY 240

Query: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300
           IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA
Sbjct: 241 IELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFA 300

Query: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360
           ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF
Sbjct: 301 ISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF 360

Query: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420
           GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE
Sbjct: 361 GKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIE 420

Query: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480
           EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT
Sbjct: 421 EYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLT 480

Query: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540
           QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG
Sbjct: 481 QDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQG 540

Query: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600
           ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC
Sbjct: 541 ICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLC 600

Query: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660
           GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ
Sbjct: 601 GYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQ 660

Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720
           MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD
Sbjct: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDD 720

Query: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ-------------- 766
           AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ              
Sbjct: 721 AKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGD 780

Query: 767 ----------------------RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 804
                                 RSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG
Sbjct: 781 GDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLG 840

Query: 805 GNKKKIRGKRFRPRSNSTE 823
           GNKKKIRGKRFRPRSNSTE
Sbjct: 841 GNKKKIRGKRFRPRSNSTE 859


>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
           sapiens]
          Length = 769

 Score =  853 bits (2204), Expect = 0.0
 Identities = 407/724 (56%), Positives = 516/724 (71%), Gaps = 10/724 (1%)

Query: 52  PLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLL 111
           P RL+  S G  E R   LDTRVR +  G    H+ Q SF + AF ++F LD+ LNH LL
Sbjct: 50  PSRLVRESSG-GEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLL 108

Query: 112 SSEYIERHIEHGGKTVEVKG-GEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLI 170
           SS+Y+ERH    G T    G G+HCYYQG +RGNP SF ALSTC GLHG+F DGN TY++
Sbjct: 109 SSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIV 168

Query: 171 EPEENDT---TQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPK-RSKRQ 226
           EP+E        +    H +Y++ L    L     E   +   P++     RP+ R KRQ
Sbjct: 169 EPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGC--REPGCLFAVPAQSAPPNRPRLRRKRQ 226

Query: 227 LRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIV 286
           +RR    V  ETKY+EL+++NDH +F++ R SVV T+ +AKSVVN+AD+IYK+QL TRIV
Sbjct: 227 VRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIV 286

Query: 287 LVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIG 346
           LVAMETWA  +K  + ++ L TL   M YRR+ + E SDA HLFSG  F+S+ SGAAY+G
Sbjct: 287 LVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVG 346

Query: 347 GICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDT 406
           GICSL  GGGVNE+G    MAVTLAQ+L  N+G++ +K + ++G+CKC D W GCIM DT
Sbjct: 347 GICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDT 406

Query: 407 GYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAEC 466
           G+YLP+KF++C+I+EY+ FL  GGG+CLFNKP KLLDPPECGNGF+E GEECDCG+  EC
Sbjct: 407 GFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQEC 466

Query: 467 VLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPN 526
              G  CCKKCTLT D+ CSDGLCC++CK++P G  CREAVN+CDI ETC+G+SSQC PN
Sbjct: 467 SRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPN 526

Query: 527 IHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKD 586
           +HK+DGY CD  QG C+GGRCKTRDRQC+ +WG    A+D++CYEKLN+EGTE+G+CG+ 
Sbjct: 527 LHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGH--AAADRFCYEKLNVEGTERGSCGRK 584

Query: 587 KDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV 646
              W+QC+K+DVLCG+LLC NI   PRLG+L G+I+S     QG+ L+C GGHV+L +  
Sbjct: 585 GSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGS 644

Query: 647 DLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHW 706
           DL YVEDGT CGP M+CL+HRCLP ++FNFSTC  S E  ICS +GVCSNE KC+C   W
Sbjct: 645 DLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDW 704

Query: 707 IGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQ 766
            G DC+ + P      TG T    G +GTNIIIG IAG +LV A++LG T WG+KN R  
Sbjct: 705 TGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRG 764

Query: 767 RSNG 770
           RS G
Sbjct: 765 RSGG 768


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score =  754 bits (1948), Expect = 0.0
 Identities = 372/742 (50%), Positives = 489/742 (65%), Gaps = 44/742 (5%)

Query: 45  VERQSIVPLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDV 104
           ++++  +P RLIY    + ES +  LDT+ R      +  H+ QASFQ++AFG+ FILD+
Sbjct: 107 MQKEITLPSRLIYYINQDSESPYHVLDTKARHQQKHNKAVHLAQASFQIEAFGSKFILDL 166

Query: 105 VLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDG 164
           +LN+ LLSS+Y+E H E+G K    KGGEHCYY G IRG  DS VALSTC+GLHGMF D 
Sbjct: 167 ILNNGLLSSDYVEIHYENG-KPQYSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFEDD 225

Query: 165 NHTYLIEP-----EENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSK-----F 214
              Y+IEP     +E  T +     H + K+   ++S        Q  N+T  +     F
Sbjct: 226 TFVYMIEPLELVHDEKSTGRP----HIIQKTLAGQYSK-------QMKNLTMERGDQWPF 274

Query: 215 ILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMAD 274
           + + +  + +++     R + EE KY+ELMIVNDH  +KKHR S  HTN +AKSVVN+ D
Sbjct: 275 LSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVD 334

Query: 275 LIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQ 334
            IYK+QL TR+VLVA+ETW   ++  I+ NP+  L EF KYR+  IK+ +DAVHL S   
Sbjct: 335 SIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYRQR-IKQHADAVHLISRVT 393

Query: 335 FESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKC 394
           F   RS  +Y GG+CS  +G GVNE+G    +A  L+QSLA N+GI  +       +C C
Sbjct: 394 FHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSS-RKPKCDC 452

Query: 395 EDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIET 454
            ++W GCIM +TG    +KF++C+I EY DFL  GGGACLFN+P+KL +P ECGNG++E 
Sbjct: 453 TESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEA 512

Query: 455 GEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKK--CKFQPMGTVCREAVNDCDI 512
           GEECDCG   EC      CCKKC+L+  + CSDG CC    C FQP G  CR+AVN+CDI
Sbjct: 513 GEECDCGFHVECY---GLCCKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDI 569

Query: 513 RETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEK 572
            E C+G+S QC PN+HK DGY+C+  QG C+ G CKTRD QC+YIWG K   SDK+CYEK
Sbjct: 570 TEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKAAGSDKFCYEK 629

Query: 573 LNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRT 632
           LN EGTEKGNCGKD D WIQC+K DV CG+LLCTN+   PR+G+L GEI  T    QGR 
Sbjct: 630 LNTEGTEKGNCGKDGDRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRV 689

Query: 633 LNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNG 692
           ++CSG HV L++D D+GYVEDGTPCGP MMCL+ +CL + + N S+C    +G +CSG+G
Sbjct: 690 IDCSGAHVVLDDDTDVGYVEDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHG 749

Query: 693 VCSNELKCVCNRHWIGSDC-------NTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGT 745
           VCSNE  C+C+  W G+DC       N + P ++  K        G + TN+IIG IAG 
Sbjct: 750 VCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPK--------GPSATNLIIGSIAGA 801

Query: 746 ILVLALILGITAWGYKNYREQR 767
           ILV A++LG T WG+KN +++R
Sbjct: 802 ILVAAIVLGGTGWGFKNVKKRR 823


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  371 bits (952), Expect = e-102
 Identities = 224/705 (31%), Positives = 341/705 (48%), Gaps = 56/705 (7%)

Query: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139
           H +  + ++       I+++  N  L++S + E H    G  V +         HCYY G
Sbjct: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123

Query: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199
           H+RG  DS V+LSTC GL G+    N +Y++EP ++ T +     + ++ ++  +     
Sbjct: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178

Query: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
             S     N+          P  S+   RR+ R   + TKY+EL+IV D+  F++    +
Sbjct: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234

Query: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
                    + N  D  Y+  L  RIVLV +E W   +K ++S++P  +L EF+ +R+  
Sbjct: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293

Query: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371
           +  ++  D   L SG  F+ +  G A I  +C+  + GG+      N  G     AVTLA
Sbjct: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349

Query: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430
             L HN G+  D        C+      GCIM   TGY  P  F+ C+ ++    L  G 
Sbjct: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408

Query: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486
           G CLFN P   +     +CGN F+E GEECDCG P EC+     CC    CTL  D+ C+
Sbjct: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465

Query: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
            GLCC+ C+ +P GT CR++ N CD+ E C+G S  C  N++  DG+SC  V G C+ G 
Sbjct: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525

Query: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605
           C+T ++QC  +WG     +   C+E++N  G   GNCGK  K ++ +C  RD  CG + C
Sbjct: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585

Query: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
               + P +G     I + + +QQG  + C G HV L +D+ D G V  GT C    +CL
Sbjct: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645

Query: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY-FPHNDDAKT 723
             +C  ++ F    C        C G GVC+N   C C  HW    C+ + F  + D+  
Sbjct: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700

Query: 724 GITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRS 768
                  G+            TI +L  IL + A G+  Y ++++
Sbjct: 701 IRQADNQGL------------TIGILVTILCLLAAGFVVYLKRKT 733


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  370 bits (951), Expect = e-102
 Identities = 213/650 (32%), Positives = 320/650 (49%), Gaps = 43/650 (6%)

Query: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139
           H +  + ++       I+++  N  L++S + E H    G  V +         HCYY G
Sbjct: 64  HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123

Query: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199
           H+RG  DS V+LSTC GL G+    N +Y++EP ++ T +     + ++ ++  +     
Sbjct: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178

Query: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
             S     N+          P  S+   RR+ R   + TKY+EL+IV D+  F++    +
Sbjct: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234

Query: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
                    + N  D  Y+  L  RIVLV +E W   +K ++S++P  +L EF+ +R+  
Sbjct: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293

Query: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371
           +  ++  D   L SG  F+ +  G A I  +C+  + GG+      N  G     AVTLA
Sbjct: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349

Query: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430
             L HN G+  D        C+      GCIM   TGY  P  F+ C+ ++    L  G 
Sbjct: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408

Query: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486
           G CLFN P   +     +CGN F+E GEECDCG P EC+     CC    CTL  D+ C+
Sbjct: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465

Query: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
            GLCC+ C+ +P GT CR++ N CD+ E C+G S  C  N++  DG+SC  V G C+ G 
Sbjct: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525

Query: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605
           C+T ++QC  +WG     +   C+E++N  G   GNCGK  K ++ +C  RD  CG + C
Sbjct: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585

Query: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
               + P +G     I + + +QQG  + C G HV L +D+ D G V  GT C    +CL
Sbjct: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645

Query: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY 714
             +C  ++ F    C        C G GVC+N   C C  HW    C+ +
Sbjct: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKF 690


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  366 bits (940), Expect = e-101
 Identities = 227/648 (35%), Positives = 311/648 (47%), Gaps = 44/648 (6%)

Query: 85  HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGG--KTVEVKGGEHCYYQGHIR 142
           H  +A  +V A G   ILD+  N  L +  Y E H    G  +T   K  +HC+Y G +R
Sbjct: 61  HPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVR 120

Query: 143 GNPDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201
               S V LSTC G+ G+     N +Y+IEP  +   Q     H +Y+S      L   P
Sbjct: 121 ETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQ-----HLIYRSE----HLKPPP 171

Query: 202 SE--FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
               F+    T   + L+   +++K++ RR  R      KY+EL +V D+L F+K+R   
Sbjct: 172 GNCGFEHSKPTTRDWALQ-FTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQ 230

Query: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
             T      + N  D  Y+  L  RI LV +E W   N   +SENP  TL  F+ +RR  
Sbjct: 231 DATKHKLIEIANYVDKFYRS-LNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKL 289

Query: 320 IKEK-SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAH 376
           + +K  D   L +G  F  +  G A +  +CS+ + GGVN     + + V  T+A  + H
Sbjct: 290 LAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGH 349

Query: 377 NIGIISDKRKLASGECKCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLF 435
           N G+  D        C       GCIM   TG+  PK F  CN  E   +L SGGG CL 
Sbjct: 350 NFGMTHDSADC----CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLS 405

Query: 436 NKPSK--LLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQCSDGLCC 491
           N P    L     CGNG++E GEECDCG   EC      CC    CTL   ++C+ G CC
Sbjct: 406 NMPDTRMLYGGRRCGNGYLEDGEECDCGEEEEC---NNPCCNASNCTLRPGAECAHGSCC 462

Query: 492 KKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRD 551
            +CK    GT+CRE    CD+ E C+G S  C  N ++MDG  C+G Q  C+ G C T  
Sbjct: 463 HQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQ 522

Query: 552 RQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGN 610
            QC+ +WG     +   C+EK+N+ G   GNCGKD +    +CN RD  CG + C +   
Sbjct: 523 EQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEA 582

Query: 611 IPRLGELDGEITSTLVVQQGRTLNCSGGHVKL--EEDVDL---GYVEDGTPCGPQMMCLE 665
            P   E +     T ++  GR + C G HV    EE+ D+   G V  GT CG   +C E
Sbjct: 583 RPL--ESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFE 640

Query: 666 HRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNT 713
            +C   + F    C     G  C+G+GVC+N   C C   W    CNT
Sbjct: 641 GQCRNTSFFETEGC-----GKKCNGHGVCNNNQNCHCLPGWAPPFCNT 683


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  328 bits (842), Expect = 1e-89
 Identities = 209/649 (32%), Positives = 319/649 (49%), Gaps = 61/649 (9%)

Query: 88  QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
           Q S+ + A G   I+ +  N DLL  +++       G  +        HC+Y+G++ G  
Sbjct: 65  QVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVH 124

Query: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHF-HSVYKSRLFEFSLDDLPSEF 204
           +S +ALS C GL G+ +  N +Y IEP +N +     HF H +Y+       +DD+  E 
Sbjct: 125 NSSIALSDCFGLRGLLHLENASYGIEPLQNSS-----HFEHIIYR-------MDDVYKEP 172

Query: 205 QQVNITPSKFILKPRPKR------SKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLS 258
            +  ++ +K I K   K       S  QL R  R V  +T+Y+EL IV D     K R  
Sbjct: 173 LKCGVS-NKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVD-----KERYD 226

Query: 259 VVHTNTYAKS-----VVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFM 313
           ++  N  A       + N  D +Y   L  RIVLV +E W   N   I       L  F+
Sbjct: 227 MMGRNQTAVREEMILLANYLDSMYI-MLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFV 285

Query: 314 KYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGK--TDLMAVT 369
           ++R  F+  + + D+  L     F  + +G A++G +CS    GG+N FG+   +  A  
Sbjct: 286 QWREKFLITRRRHDSAQLVLKKGFGGT-AGMAFVGTVCSRSHAGGINVFGQITVETFASI 344

Query: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSG 429
           +A  L HN+G+  D  +    +C C      CIM ++G    + F+ C+ E++     + 
Sbjct: 345 VAHELGHNLGMNHDDGR----DCSCGA--KSCIM-NSGASGSRNFSSCSAEDFEKLTLNK 397

Query: 430 GGACLFN--KPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK--KCTLTQDSQC 485
           GG CL N  KP +    P CGN  ++ GEECDCGTP EC L+   CC+   C L   ++C
Sbjct: 398 GGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELD--PCCEGSTCKLKSFAEC 455

Query: 486 SDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGG 545
           + G CCK C+F P GT+CR   ++CD+ E C+G+S  C P++   +GY C   +  C+ G
Sbjct: 456 AYGDCCKDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNG 515

Query: 546 RCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLC 605
            C+  D QC+ I+G K  A+ K C+ ++N +G   GNCG   + + +C   + LCG L C
Sbjct: 516 MCQYYDAQCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQC 575

Query: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
            N+  IP  G     I   ++    R   C G   +L  DV D G V +GT CG   +C 
Sbjct: 576 ENVQEIPVFG-----IVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCGAGKICR 630

Query: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNT 713
             +C+  +  N+   +  K    C G+GVC++   C C   W   +C T
Sbjct: 631 NFQCVDASVLNYDCDVQKK----CHGHGVCNSNKNCHCENGWAPPNCET 675


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  327 bits (839), Expect = 2e-89
 Identities = 204/643 (31%), Positives = 308/643 (47%), Gaps = 42/643 (6%)

Query: 87  DQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGN 144
           D     ++A G   +L++  NH LL+  YIE H    G+ V +     +HC+YQG +RG 
Sbjct: 64  DMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGF 123

Query: 145 PDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSE 203
           PDS+V L TC G+ G+     N +Y + P       +DF  H +++      +       
Sbjct: 124 PDSWVVLCTCSGMSGLITLSRNASYYLRPWP-PRGSKDFSTHEIFRMEQL-LTWKGTCGH 181

Query: 204 FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTN 263
               N      +      R +R+ RR         KY+EL IV DH +F     ++ HT 
Sbjct: 182 RDPGNKAGMTSLPGGPQSRGRREARR-------TRKYLELYIVADHTLFLTRHRNLNHTK 234

Query: 264 TYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK 323
                V N  D + +  L  ++ L  +E W   ++  ++++   TL  F+++RR    ++
Sbjct: 235 QRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQR 293

Query: 324 S-DAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL---MAVTLAQSLAHNIG 379
             D+  L +G  F+ +  G A + G+C     GGV+    ++L    A T+A  + H++G
Sbjct: 294 PHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVST-DHSELPIGAAATMAHEIGHSLG 352

Query: 380 IISDKRKLASGEC-KCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 437
           +  D      G C +      GC+M   TG+  P+ F+ C+  +   F   GGGACL N 
Sbjct: 353 LSHDP----DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNA 408

Query: 438 PSKLLDPPE--CGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGLCCKK 493
           P   L  P   CGNGF+E GEECDCG   EC      CC    C+L   +QC+ G CC +
Sbjct: 409 PDPGLPVPPALCGNGFVEAGEECDCGPGQEC---RDLCCFAHNCSLRPGAQCAHGDCCVR 465

Query: 494 CKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQ 553
           C  +P G +CR+A+ DCD+ E C+G SS C P+++ +DG  C    G C+ G C T ++Q
Sbjct: 466 CLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQ 525

Query: 554 CKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGNIP 612
           C+ +WG     + + C++ +N  G   GNCG+D +  ++ C  RD LCG L C   G  P
Sbjct: 526 CQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ--GGKP 583

Query: 613 RLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVD---LGYVEDGTPCGPQMMCLEHRCL 669
            L         + V   G+ + C G        +D   LG VE GT CGP+M+C   RC 
Sbjct: 584 SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCR 643

Query: 670 PVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN 712
             A      CL     T C  +GVC++   C C   W    C+
Sbjct: 644 KNAFQELQRCL-----TACHSHGVCNSNHNCHCAPGWAPPFCD 681


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136

Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185

Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244

Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303

Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360

Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418

Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475

Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535

Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595

Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654

Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136

Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185

Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244

Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303

Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360

Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418

Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475

Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535

Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595

Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654

Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136

Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185

Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244

Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303

Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360

Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418

Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475

Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535

Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595

Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654

Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136

Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185

Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244

Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303

Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360

Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418

Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475

Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535

Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595

Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654

Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136

Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185

Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244

Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303

Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360

Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418

Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475

Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535

Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595

Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654

Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  313 bits (801), Expect = 6e-85
 Identities = 212/652 (32%), Positives = 306/652 (46%), Gaps = 47/652 (7%)

Query: 97  GTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNPDSFVALSTC 154
           G S IL+++ N +L+         +  G  V  +G   E+C YQG +RG   S+V++ TC
Sbjct: 77  GDSHILELLQNRELVPGRPTLVWYQPDGTRVVSEGHTLENCCYQGRVRGYAGSWVSICTC 136

Query: 155 HGLHGMFYDGNHTYLIEPEENDTTQE---DFHFHSVYKSRLFEFSLDDLPSEFQQVNITP 211
            GL G+        ++ PE + T ++   D     +  SR+ +  L   P     ++   
Sbjct: 137 SGLRGLV-------VLTPERSYTLEQGPGDLQGPPII-SRIQDLHL---PGHTCALSWRE 185

Query: 212 SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVN 271
           S    KP      ++  R  R+V  ETK +EL+IV DH   +K+R    H       V  
Sbjct: 186 SVHTQKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-DFQHLLNRTLEVAL 244

Query: 272 MADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK--SDAVHL 329
           + D  ++  L  R+ LV +E W   +   IS NP +TL  F+ +RR  +  +   D+  L
Sbjct: 245 LLDTFFRP-LNVRVALVGLEAWTQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDSAQL 303

Query: 330 FSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAV--TLAQSLAHNIGIISDKRKL 387
            +G+ F     G A    ICS    GGVN    T ++ V  ++A  L H++G+  D   L
Sbjct: 304 VTGTSFSGPTVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHD---L 360

Query: 388 ASGECKCEDTWSG--CIMGDTGYYLPK-KFTQCNIEEYHDFLNSGGGACLFNKPSKLLDP 444
               C C        CIM  +  +LP   F+ C+       L  G G+CLF +   L  P
Sbjct: 361 PGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSL--P 418

Query: 445 PE---CGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQC-SDGLCCKKCKFQP 498
           P    CGN F+E GE+CDCG   +CV     CC    C L   +QC SDG CC+ C+ +P
Sbjct: 419 PMAAFCGNMFVEPGEQCDCGFLDDCV---DPCCDSLTCQLRPGAQCASDGPCCQNCQLRP 475

Query: 499 MGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIW 558
            G  CR    DCD+ E C G+SSQC P++   DG  C G Q +C  GRC +  +QC+ +W
Sbjct: 476 SGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSLW 535

Query: 559 GQKVTASDKYCYEKLNIEGTEKGNCGKD-KDTWIQCNKRDVLCGYLLCTNIGNIPRLGEL 617
           G     +   C +  N  G   G+CG++   +++ C  RD +CG L C      P LG +
Sbjct: 536 GPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQPLLGSI 595

Query: 618 DGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVE-DGTPCGPQMMCLEHRCLPVASFNF 676
              +  T+ V  G  LNCS  H+ L  DV    +   GT CGP ++C++HRC  V     
Sbjct: 596 RDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTLPGTACGPGLVCIDHRCQRVDLLGA 654

Query: 677 STCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
             C S      C G+GVC +   C C   W   DC T         TG+ LS
Sbjct: 655 QECRSK-----CHGHGVCDSNRHCYCEEGWAPPDCTTQLKATSSLTTGLLLS 701


>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 775

 Score =  310 bits (795), Expect = 3e-84
 Identities = 206/702 (29%), Positives = 321/702 (45%), Gaps = 79/702 (11%)

Query: 88  QASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGNP 145
           +  +++   G   +L +  N +LL+  Y E +    GK +       + CYYQGHI    
Sbjct: 56  ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQIMDDCYYQGHILNEK 115

Query: 146 DSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDL----- 200
            S  ++STC GL G F  G+  Y IEP        D   H+++K    E + D       
Sbjct: 116 VSDASISTCRGLRGYFSQGDQRYFIEPLS--PIHRDGQEHALFKYNPDEKNYDSTCGMDG 173

Query: 201 ---PSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRL 257
                + QQ    P+  ++K +            R V+E  KYIE  +V D+  FK++  
Sbjct: 174 VLWAHDLQQNIALPATKLVKLKD-----------RKVQEHEKYIEYYLVLDNGEFKRYNE 222

Query: 258 SVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRR 317
           +          + N  +++YK +L T + LV ME W   +K  I+ N   TL  F K+R 
Sbjct: 223 NQDEIRKRVFEMANYVNMLYK-KLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRG 281

Query: 318 DFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL-MAVTLAQSL 374
             +  +++ D   L + ++   +  G A++  +CS    G V +     L +A T+A  +
Sbjct: 282 SVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCSPYSVGVVQDHSDNLLRVAGTMAHEM 341

Query: 375 AHNIGIISDKRKLASGECKCEDTWSGCIMGDT-GYYLPKKFTQCNIEEYHDFLNSGGGAC 433
            HN G+  D        CKC  T   C+M     +Y+P  F+ C+   Y  F       C
Sbjct: 342 GHNFGMFHDDYS-----CKCPSTI--CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNC 394

Query: 434 LFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGL 489
           LFN P  + ++  P CGN  +E GE+CDCGT  EC      CC  K C +    QC+ G 
Sbjct: 395 LFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECT---NICCDAKTCKIKATFQCALGE 451

Query: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549
           CC+KC+F+  G VCR A ++CD+ E C+G S  C  +  +++G+ C   +G C  G C T
Sbjct: 452 CCEKCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPT 511

Query: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCT-NI 608
              QC  +WG     +DK CY + N  G++ G C +  DT I C   D +CG L C    
Sbjct: 512 LQEQCTELWGPGTEVADKSCYNR-NEGGSKYGYCRRVDDTLIPCKANDTMCGKLFCQGGS 570

Query: 609 GNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRC 668
            N+P  G +   +T      +             +   ++G V +GT CG   +C+   C
Sbjct: 571 DNLPWKGRIVTFLTCKTFDPE-------------DTSQEIGMVANGTKCGDNKVCINAEC 617

Query: 669 LPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLS 728
           + +     ST  SSK    C G+ VC +EL+C C   WI  DC       DD+       
Sbjct: 618 VDIEKAYKSTNCSSK----CKGHAVCDHELQCQCEEGWIPPDC-------DDSSV----- 661

Query: 729 GNGVAGTNIIIGII---AGTILVLALILGITAWGYKNYREQR 767
              V   +I++G++   A   +V+A+++   +   K  ++QR
Sbjct: 662 ---VFHFSIVVGVLFPMAVIFVVVAMVIRHQSSREKQKKDQR 700


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  307 bits (787), Expect = 3e-83
 Identities = 192/600 (32%), Positives = 292/600 (48%), Gaps = 38/600 (6%)

Query: 87  DQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGG--EHCYYQGHIRGN 144
           D     ++A G   +L++  NH LL+  YIE H    G+ V +     +HC+YQG +RG 
Sbjct: 64  DMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGF 123

Query: 145 PDSFVALSTCHGLHGMF-YDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSE 203
           PDS+V L TC G+ G+     N +Y + P       +DF  H +++      +       
Sbjct: 124 PDSWVVLCTCSGMSGLITLSRNASYYLRPWP-PRGSKDFSTHEIFRMEQL-LTWKGTCGH 181

Query: 204 FQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTN 263
               N      +      R +R+ RR         KY+EL IV DH +F     ++ HT 
Sbjct: 182 RDPGNKAGMTSLPGGPQSRGRREARR-------TRKYLELYIVADHTLFLTRHRNLNHTK 234

Query: 264 TYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEK 323
                V N  D + +  L  ++ L  +E W   ++  ++++   TL  F+++RR    ++
Sbjct: 235 QRLLEVANYVDQLLRT-LDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQR 293

Query: 324 S-DAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDL---MAVTLAQSLAHNIG 379
             D+  L +G  F+ +  G A + G+C     GGV+    ++L    A T+A  + H++G
Sbjct: 294 PHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVST-DHSELPIGAAATMAHEIGHSLG 352

Query: 380 IISDKRKLASGEC-KCEDTWSGCIMGD-TGYYLPKKFTQCNIEEYHDFLNSGGGACLFNK 437
           +  D      G C +      GC+M   TG+  P+ F+ C+  +   F   GGGACL N 
Sbjct: 353 LSHDP----DGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNA 408

Query: 438 PSKLLDPPE--CGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDSQCSDGLCCKK 493
           P   L  P   CGNGF+E GEECDCG   EC      CC    C+L   +QC+ G CC +
Sbjct: 409 PDPGLPVPPALCGNGFVEAGEECDCGPGQEC---RDLCCFAHNCSLRPGAQCAHGDCCVR 465

Query: 494 CKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQ 553
           C  +P G +CR+A+ DCD+ E C+G SS C P+++ +DG  C    G C+ G C T ++Q
Sbjct: 466 CLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQ 525

Query: 554 CKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKD-TWIQCNKRDVLCGYLLCTNIGNIP 612
           C+ +WG     + + C++ +N  G   GNCG+D +  ++ C  RD LCG L C   G  P
Sbjct: 526 CQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQ--GGKP 583

Query: 613 RLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVD---LGYVEDGTPCGPQMMC-LEHRC 668
            L         + V   G+ + C G        +D   LG VE GT CGP+M+C   H C
Sbjct: 584 SLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCNSNHNC 643


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  290 bits (741), Expect = 5e-78
 Identities = 206/719 (28%), Positives = 325/719 (45%), Gaps = 87/719 (12%)

Query: 73  RVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTV--EVK 130
           RVR  L      H ++ S+ + A G +F L +  N DLL S Y E +    G  V  + +
Sbjct: 41  RVRRALPSHLGLHPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPR 100

Query: 131 GGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKS 190
           G +HC+YQGH+ G PDS  +LSTC GL G F  G+  +LIEP +      +   H+VY++
Sbjct: 101 GQDHCFYQGHVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGG---EGGRHAVYQA 157

Query: 191 R--LFEFSLDDLPSEFQQVNITP-SKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVN 247
              L       +  +     + P +  + +PRP  S             ET+Y+EL +V 
Sbjct: 158 EHLLQTAGTCGVSDDSLGSLLGPRTAAVFRPRPGDSLPS---------RETRYVELYVVV 208

Query: 248 DHLMFKK--HRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENP 305
           D+  F+      +V H       VVN  D +Y+ +L  R+VLV +E W + ++F +S +P
Sbjct: 209 DNAEFQMLGSEAAVRHR---VLEVVNHVDKLYQ-KLNFRVVLVGLEIWNSQDRFHVSPDP 264

Query: 306 LITLREFMKY--RRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT 363
            +TL   + +  R+   +   D V L +G  F  +  G A +  +CS   G    +  K 
Sbjct: 265 SVTLENLLTWQARQRTRRHLHDNVQLITGVDFTGTTVGFARVSAMCSHSSGAVNQDHSKN 324

Query: 364 DL-MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSG--CIM-GDTGYYLPKKFTQCNI 419
            + +A T+A  + HN+G+  D+       C+C++ +    CIM G  G   P+ F+ C+ 
Sbjct: 325 PVGVACTMAHEMGHNLGMDHDENVQG---CRCQERFEAGRCIMAGSIGSSFPRMFSDCSQ 381

Query: 420 EEYHDFLNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK- 476
                FL      CL N P  S L+  P CGN F+E GE+CDCG P +C      CC   
Sbjct: 382 AYLESFLERPQSVCLANAPDLSHLVGGPVCGNLFVERGEQCDCGPPEDC---RNRCCNST 438

Query: 477 -CTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSC 535
            C L + +QC+ G CC++CK +P G +CR   + CD+ E C G   +C  +  + +G  C
Sbjct: 439 TCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPC 498

Query: 536 DGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNK 595
            G  G C+ G C T  +QC+  WG    A+++ C+    + G +      D    +QC  
Sbjct: 499 SG--GYCYNGACPTLAQQCQAFWGPGGQAAEESCFSYDILPGCKASRYRADMCGVLQCKG 556

Query: 596 RDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655
                G  +C              ++   L  + G                    V +GT
Sbjct: 557 GQQPLGRAICIV------------DVCHALTTEDGTAYEP---------------VPEGT 589

Query: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYF 715
            CGP+ +C + RC  +  +  S C +      C  +GVC+++ +C C+  W    C    
Sbjct: 590 RCGPEKVCWKGRCQDLHVYRSSNCSAQ-----CHNHGVCNHKQECHCHAGWAPPHCAKLL 644

Query: 716 PHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRSNGLSHS 774
                A      SG+        + +    +LVL  ++ +T  G   YR+ RS  LS +
Sbjct: 645 TEVHAA------SGS--------LPVFVVVVLVLLAVVLVTLAGIIVYRKARSRILSRN 689


>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
           sapiens]
          Length = 776

 Score =  281 bits (720), Expect = 1e-75
 Identities = 183/589 (31%), Positives = 280/589 (47%), Gaps = 42/589 (7%)

Query: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
           + CYY G++ G P+S VALSTC G   GM    +  Y I+P     T E    H VYK  
Sbjct: 157 DDCYYHGYVEGVPESLVALSTCSGGFLGMLQINDLVYEIKPISVSATFE----HLVYK-- 210

Query: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEET--KYIELMIVNDH 249
                 DD      +  +T  K   +   + S     +    V   T  +++EL++V D+
Sbjct: 211 ---IDSDDTQFPPMRCGLTEEKIAHQMELQLSYNFTLKQSSFVGWWTHQRFVELVVVVDN 267

Query: 250 LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITL 309
           + +   + +         +VVN+ D  Y   L+  ++L  ++ W   N    S +    L
Sbjct: 268 IRYLFSQSNATTVQHEVFNVVNIVDSFYHP-LEVDVILTGIDIWTASNPLPTSGDLDNVL 326

Query: 310 REFMKYRRDFIKEK--SDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLM- 366
            +F  ++   +  +   D  HLF     +  + G AY+ GIC      GV+ F    L+ 
Sbjct: 327 EDFSIWKNYNLNNRLQHDVAHLFI-KDTQGMKLGVAYVKGICQNPFNTGVDVFEDNRLVV 385

Query: 367 -AVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDF 425
            A+TL   L HN+G+  D +      C CE  W  CIM      +  KF+ C+  +Y D 
Sbjct: 386 FAITLGHELGHNLGMQHDTQW-----CVCELQW--CIM-HAYRKVTTKFSNCSYAQYWDS 437

Query: 426 LNSGGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDS 483
             S G  C+   P    +     CGN  +E GEECDCGT  +C  +   C   CTL   +
Sbjct: 438 TISSG-LCIQPPPYPGNIFRLKYCGNLVVEEGEECDCGTIRQCAKDPC-CLLNCTLHPGA 495

Query: 484 QCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICF 543
            C+ G+CCK CKF P GT+CR+ V +CD+ E C+G S QC  +++  DG SC+ V   C+
Sbjct: 496 ACAFGICCKDCKFLPSGTLCRQQVGECDLPEWCNGTSHQCPDDVYVQDGISCN-VNAFCY 554

Query: 544 GGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYL 603
              C   D QCK I+GQ   ++ + CY+++N +G   G+CG    T+++C   D++CG +
Sbjct: 555 EKTCNNHDIQCKEIFGQDARSASQSCYQEINTQGNRFGHCGIVGTTYVKCWTPDIMCGRV 614

Query: 604 LCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMM 662
            C N+G IP L E      ST+         C G    L   + D+G V+DGT CGP+ +
Sbjct: 615 QCENVGVIPNLIE-----HSTVQQFHLNDTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKI 669

Query: 663 CLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
           C+  +C  +   +      + +   C+  G+C+N+  C CN  W    C
Sbjct: 670 CIRKKCASMVHLS-----QACQPKTCNMRGICNNKQHCHCNHEWAPPYC 713


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score =  277 bits (709), Expect = 3e-74
 Identities = 183/593 (30%), Positives = 294/593 (49%), Gaps = 51/593 (8%)

Query: 133 EHCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSR 191
           + CYY G++ G P+S V  S C G   G+      TY IEP  +  T E    H VYK  
Sbjct: 107 DDCYYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEPIRHSATFE----HLVYKVN 162

Query: 192 LFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEE---ETKYIELMIVND 248
             E     +     +  +   +   +     +       P++  +      ++EL++V +
Sbjct: 163 SNETQFPAMRCGLTEKEVARQQLEFEEAENSALE-----PKSAGDWWTHAWFLELVVVVN 217

Query: 249 H--LMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPL 306
           H   ++ +  +S V  + +   VVN+ D +Y+ QL T I+L+ +E W   N F ++    
Sbjct: 218 HDFFIYSQSNISKVQEDVFL--VVNIVDSMYQ-QLGTYIILIGIEIWNQGNVFPMTSIEQ 274

Query: 307 ITLREFMKYRRDFIKE-KSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEF-GKT- 363
           + L +F ++++  + + + DA H+F  +   S   G AY+ GIC      GV+ F G T 
Sbjct: 275 V-LNDFSQWKQISLSQLQHDAAHMFIKNSLISIL-GLAYVAGICRPPIDCGVDNFQGDTW 332

Query: 364 DLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYH 423
            L A T+A  L H +G+  D+     GE        GCIM +T     +KFT C+   Y 
Sbjct: 333 SLFANTVAHELGHTLGMQHDEEFCFCGE-------RGCIM-NTFRVPAEKFTNCS---YA 381

Query: 424 DFLNS--GGGACLFNKP--SKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTL 479
           DF+ +    G+CL N P   ++     CGNG +E  E+CDCG+  +C  + A C   CTL
Sbjct: 382 DFMKTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCE-QDACCLLNCTL 440

Query: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539
              + C+ GLCCK CKF P G +CR+ VN+CD+ E C+G S QC  + +  DG  C    
Sbjct: 441 RPGAACAFGLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSD-S 499

Query: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599
             C+  RC   D+ C+ I+G+   ++ + CY+++N +G   G+CG +  T+++C+  DV 
Sbjct: 500 AYCYQKRCNNHDQHCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVF 559

Query: 600 CGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCG 658
           CG + C N+ +IP L +       TL       + C G    L  ++ D+G V+DGT CG
Sbjct: 560 CGRVQCENVRDIPLLQD-----HFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCG 614

Query: 659 PQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
           P  +C+  +C+ ++  +   CL       C+  G+C+N+  C C   W    C
Sbjct: 615 PGKICIHKKCVSLSVLS-HVCLPE----TCNMKGICNNKHHCHCGYGWSPPYC 662


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score =  267 bits (683), Expect = 3e-71
 Identities = 182/633 (28%), Positives = 294/633 (46%), Gaps = 49/633 (7%)

Query: 84  THVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGK--TVEVKGGEHCYYQGHI 141
           T+ ++  +++     + +L ++ + + L S Y E      G+  T   +  +HC+YQG I
Sbjct: 54  TYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSI 113

Query: 142 RGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLP 201
               DS  ++STC+GL G F   +  YLIEP +     E    H V+K  L       +P
Sbjct: 114 VHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGE----HLVFKYNL------RVP 163

Query: 202 SEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVH 261
                 + T   F  K  P  ++ +     + + +E KY+EL IV D  +++++      
Sbjct: 164 YG-ANYSCTELNFTRKTVPGDNESEEDSKIKGIHDE-KYVELFIVADDTVYRRNGHPHNK 221

Query: 262 TNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIK 321
                  +VN  ++IYK  L   + LV +E W  ++K  +  N   TL  F  ++   +K
Sbjct: 222 LRNRIWGMVNFVNMIYKT-LNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILK 280

Query: 322 EKSDAVH--LFSGSQFESSRSGAAYIGGIC------SLLKGGGVNEFGKTDLMAVTLAQS 373
            + D  H  L SG    S   G +Y GG+C      S++K    +    T+++A  +A  
Sbjct: 281 TRKDFDHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIK----DLLPDTNIIANRMAHQ 336

Query: 374 LAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGAC 433
           L HN+G+  D       E  C      C+M   G     KF++C+  +YH +L      C
Sbjct: 337 LGHNLGMQHD-------EFPCTCPSGKCVMDSDGSIPALKFSKCSQNQYHQYLKDYKPTC 389

Query: 434 LFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCSDGL 489
           + N P      D   CGN  ++ GEECDCG   EC      CC    C L     C++G 
Sbjct: 390 MLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECT---NPCCDAHTCVLKPGFTCAEGE 446

Query: 490 CCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKT 549
           CC+ C+ +  G++CR A ++CD  E C+G+S  C  +  +++G+ C   +G CF G+C T
Sbjct: 447 CCESCQIKKAGSICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPT 506

Query: 550 RDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIG 609
           R+ QC  ++  +   S   CY K+N +G + G C   ++ ++ C ++DV CG + CT   
Sbjct: 507 REDQCSELFDDEAIESHDICY-KMNTKGNKFGYCKNKENRFLPCEEKDVRCGKIYCTGGE 565

Query: 610 NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCL 669
               LGE   +       Q+  T+ C    +   +  D+G V  GT CG  M+C    CL
Sbjct: 566 LSSLLGE--DKTYHLKDPQKNATVKCKTIFL-YHDSTDIGLVASGTKCGEGMVCNNGECL 622

Query: 670 PVASFNFSTCLSSKEGTICSGNGVCSNELKCVC 702
            +     ST   S+    C+ N V  + L+C C
Sbjct: 623 NMEKVYISTNCPSQ----CNENPVDGHGLQCHC 651


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  258 bits (660), Expect = 1e-68
 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)

Query: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
           +CYY G++ G+P+S V+LSTC G   G+    +  Y I+P    TT E    H VYK   
Sbjct: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154

Query: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
            E     + S F Q  IT             + +      + ++++ Y+         E+
Sbjct: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202

Query: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
           ++V D+ ++ ++  +          +VN+ D I  D +  +++L  +E W   N   + +
Sbjct: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260

Query: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
           +   ++  + K++ + I  + + D  HLF+        SG     G+C+  +   +  F 
Sbjct: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319

Query: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
              L   ++ +A  L HN+G+  D+       C+C      CIM + G     KF+ C+ 
Sbjct: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371

Query: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
            ++ ++        L    +K + +   CGNG +E GEECDCG    C  +   C   CT
Sbjct: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430

Query: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
           LT  S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C  + +  DG  C   
Sbjct: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489

Query: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
           +G C+   C  R+ QC+ I+G     + + CY++LN  G   G+CG    T+I+CN  DV
Sbjct: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549

Query: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
            CG + C N+  IP + +      +T+   +   + C      L  +  D+G V+DGT C
Sbjct: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604

Query: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
           G   +C+   C+ +   N     S+     C+  G+C+N+  C CN  W   +C
Sbjct: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  258 bits (660), Expect = 1e-68
 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)

Query: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
           +CYY G++ G+P+S V+LSTC G   G+    +  Y I+P    TT E    H VYK   
Sbjct: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154

Query: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
            E     + S F Q  IT             + +      + ++++ Y+         E+
Sbjct: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202

Query: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
           ++V D+ ++ ++  +          +VN+ D I  D +  +++L  +E W   N   + +
Sbjct: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260

Query: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
           +   ++  + K++ + I  + + D  HLF+        SG     G+C+  +   +  F 
Sbjct: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319

Query: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
              L   ++ +A  L HN+G+  D+       C+C      CIM + G     KF+ C+ 
Sbjct: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371

Query: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
            ++ ++        L    +K + +   CGNG +E GEECDCG    C  +   C   CT
Sbjct: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430

Query: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
           LT  S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C  + +  DG  C   
Sbjct: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489

Query: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
           +G C+   C  R+ QC+ I+G     + + CY++LN  G   G+CG    T+I+CN  DV
Sbjct: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549

Query: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
            CG + C N+  IP + +      +T+   +   + C      L  +  D+G V+DGT C
Sbjct: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604

Query: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
           G   +C+   C+ +   N     S+     C+  G+C+N+  C CN  W   +C
Sbjct: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  258 bits (660), Expect = 1e-68
 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)

Query: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
           +CYY G++ G+P+S V+LSTC G   G+    +  Y I+P    TT E    H VYK   
Sbjct: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154

Query: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
            E     + S F Q  IT             + +      + ++++ Y+         E+
Sbjct: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202

Query: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
           ++V D+ ++ ++  +          +VN+ D I  D +  +++L  +E W   N   + +
Sbjct: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260

Query: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
           +   ++  + K++ + I  + + D  HLF+        SG     G+C+  +   +  F 
Sbjct: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319

Query: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
              L   ++ +A  L HN+G+  D+       C+C      CIM + G     KF+ C+ 
Sbjct: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371

Query: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
            ++ ++        L    +K + +   CGNG +E GEECDCG    C  +   C   CT
Sbjct: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430

Query: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
           LT  S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C  + +  DG  C   
Sbjct: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489

Query: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
           +G C+   C  R+ QC+ I+G     + + CY++LN  G   G+CG    T+I+CN  DV
Sbjct: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549

Query: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
            CG + C N+  IP + +      +T+   +   + C      L  +  D+G V+DGT C
Sbjct: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604

Query: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
           G   +C+   C+ +   N     S+     C+  G+C+N+  C CN  W   +C
Sbjct: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score =  258 bits (660), Expect = 1e-68
 Identities = 169/594 (28%), Positives = 279/594 (46%), Gaps = 55/594 (9%)

Query: 134 HCYYQGHIRGNPDSFVALSTCHG-LHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRL 192
           +CYY G++ G+P+S V+LSTC G   G+    +  Y I+P    TT E    H VYK   
Sbjct: 99  NCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFE----HLVYKMDS 154

Query: 193 FEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYI---------EL 243
            E     + S F Q  IT             + +      + ++++ Y+         E+
Sbjct: 155 EEKQFSTMRSGFMQNEIT------------CRMEFEEIDNSTQKQSSYVGWWIHFRIVEI 202

Query: 244 MIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISE 303
           ++V D+ ++ ++  +          +VN+ D I  D +  +++L  +E W   N   + +
Sbjct: 203 VVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSIL-DVIGVKVLLFGLEIWTNKNLIVV-D 260

Query: 304 NPLITLREFMKYRRDFI--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFG 361
           +   ++  + K++ + I  + + D  HLF+        SG     G+C+  +   +  F 
Sbjct: 261 DVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGL-SGIGAFRGMCTPHRSCAIVTFM 319

Query: 362 KTDL--MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNI 419
              L   ++ +A  L HN+G+  D+       C+C      CIM + G     KF+ C+ 
Sbjct: 320 NKTLGTFSIAVAHHLGHNLGMNHDE-----DTCRCSQP--RCIMHE-GNPPITKFSNCSY 371

Query: 420 EEYHDFLNSGGGACLFNKPSK-LLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCT 478
            ++ ++        L    +K + +   CGNG +E GEECDCG    C  +   C   CT
Sbjct: 372 GDFWEYTVERTKCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC-CLSNCT 430

Query: 479 LTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGV 538
           LT  S C+ GLCCK CKF P G VCR+ VN+CD+ E C+G S +C  + +  DG  C   
Sbjct: 431 LTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK-E 489

Query: 539 QGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDV 598
           +G C+   C  R+ QC+ I+G     + + CY++LN  G   G+CG    T+I+CN  DV
Sbjct: 490 RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCGIKNATYIKCNISDV 549

Query: 599 LCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKL-EEDVDLGYVEDGTPC 657
            CG + C N+  IP + +      +T+   +   + C      L  +  D+G V+DGT C
Sbjct: 550 QCGRIQCENVTEIPNMSD-----HTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTEC 604

Query: 658 GPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDC 711
           G   +C+   C+ +   N     S+     C+  G+C+N+  C CN  W   +C
Sbjct: 605 GIDHICIHRHCVHITILN-----SNCSPAFCNKRGICNNKHHCHCNYLWDPPNC 653


>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
           sapiens]
          Length = 735

 Score =  253 bits (646), Expect = 6e-67
 Identities = 169/597 (28%), Positives = 270/597 (45%), Gaps = 62/597 (10%)

Query: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194
           C+YQG+I G P S V +STC GL G+    N +Y IEP E+    E    H +Y      
Sbjct: 92  CHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFE----HVIY------ 141

Query: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEE---TKYIELMIVNDHLM 251
                      QV    +   L        R L    ++VE +    KYIE+ ++ +  +
Sbjct: 142 -----------QVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHVIVEKQL 190

Query: 252 FKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLRE 311
           +                ++ + + I+       I+L ++E W  +NK A +      L  
Sbjct: 191 YNHMGSDTTVVAQKVFQLIGLTNAIFVS-FNITIILSSLELWIDENKIATTGEANELLHT 249

Query: 312 FMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAV 368
           F++++  ++  +   V      + +S+  GA + G +C     GGV    +T   + +AV
Sbjct: 250 FLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISLESLAV 309

Query: 369 TLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFL 426
            LAQ L+ ++GI  D         KC+ + + CIM     +    K F+ C+ E++  F+
Sbjct: 310 ILAQLLSLSMGITYDDIN------KCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFI 363

Query: 427 NSGGGACLFNKPSKLLDP-----PECGNGFIETGEECDCGTPAECVLEGAECCK--KCTL 479
           +     CL N+P   LDP       CGN  +E GEECDCGT  +C L G  CC    C  
Sbjct: 364 SKQKSQCLHNQPR--LDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRF 421

Query: 480 TQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQ 539
              S C++G CC+ C F     +CR +  +CD+ E C+G+S+ C  N +   G+ C   Q
Sbjct: 422 KAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ 481

Query: 540 GICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVL 599
            IC  G C + D+QC   +G++V      CY  LN +    GNCG     + QC   ++ 
Sbjct: 482 WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQ 541

Query: 600 CGYLLCTNIG----NIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGT 655
           CG L+C  +G     IPR   +   I+  L +     +  +  H     D    +++DGT
Sbjct: 542 CGKLICKYVGKFLLQIPRATIIYANISGHLCI----AVEFASDHA----DSQKMWIKDGT 593

Query: 656 PCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN 712
            CG   +C   RC+  +   +  C + K    C+  GVC+N+  C C+  ++  DC+
Sbjct: 594 SCGSNKVCRNQRCVSSSYLGYD-CTTDK----CNDRGVCNNKKHCHCSASYLPPDCS 645


>gi|148664238 a disintegrin and metalloprotease domain 32 [Homo
           sapiens]
          Length = 787

 Score =  252 bits (643), Expect = 1e-66
 Identities = 201/718 (27%), Positives = 331/718 (46%), Gaps = 63/718 (8%)

Query: 135 CYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFE 194
           CYYQG+I G PDS V LSTC GL G+    N +Y IEP E+    +    H +YK     
Sbjct: 95  CYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESAVEFQ----HVLYK----- 145

Query: 195 FSLDDLPSEFQQVNITPSKFILKPRPKRSKRQL--RRYPRNVEEETKYIELMIVNDHLMF 252
                L +E   + I   +  LK +P      +  +  P   +    Y+E+ IV D  ++
Sbjct: 146 -----LKNEDNDIAIFIDRS-LKEQPMDDNIFISEKSEPAVPDLFPLYLEMHIVVDKTLY 199

Query: 253 KKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREF 312
                  +        +V +A+ ++  Q K  IVL ++E W+ +NK +        L++F
Sbjct: 200 DYWGSDSMIVTNKVIEIVGLANSMFT-QFKVTIVLSSLELWSDENKISTVGEADELLQKF 258

Query: 313 MKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKT---DLMAVT 369
           +++++ ++  +   +             GA + G +C      GV  + K    +  AV 
Sbjct: 259 LEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYSAGVALYPKEITLEAFAVI 318

Query: 370 LAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLP--KKFTQCNIEEYHDFLN 427
           + Q LA ++GI  D  K      KC+ + S CIM          K F+ C++  + +F++
Sbjct: 319 VTQMLALSLGISYDDPK------KCQCSESTCIMNPEVVQSNGVKTFSSCSLRSFQNFIS 372

Query: 428 SGGGACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECC--KKCTLTQDS 483
           + G  CL NKP   K    P CGNG +E  E CDCGT A+C    A CC  + C L   +
Sbjct: 373 NVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQC--GPASCCDFRTCVLKDGA 430

Query: 484 QCSDGLCCKKCKFQPMGTVCR-EAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGIC 542
           +C  GLCCK C+    G  CR +A  +CDI E C+G+S +C P+I  ++G SC   + IC
Sbjct: 431 KCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGSSPECGPDITLINGLSCKNNKFIC 490

Query: 543 FGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDT-WIQCNKRDVLCG 601
           + G C   D +C+ ++G+    +   CYE++  +    GNCG+D++  ++ C  R+++CG
Sbjct: 491 YDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICG 550

Query: 602 YLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQ 660
            L+CT     P   + +G++    V    R   C     KL   V D   V++G+ C   
Sbjct: 551 RLVCTYPTRKP-FHQENGDVIYAFV----RDSVCITVDYKLPRTVPDPLAVKNGSQCDIG 605

Query: 661 MMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCN------TY 714
            +C+   C+       S  + S++   CSG+GVC +  KC C+  +   +C       + 
Sbjct: 606 RVCVNRECVESRIIKASAHVCSQQ---CSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSI 662

Query: 715 FPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVL--ALILG---ITAWGYKNYR----E 765
           FP  D        SG     T ++  +IA  IL++  A++L    +  W  K       E
Sbjct: 663 FPEEDMGSIMERASGK-TENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSSE 721

Query: 766 QRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTE 823
            +S G + +++ +              R  S+S Q +   +K +   + +  RS S +
Sbjct: 722 SKSEGSTQTYASQSSSEGSTQTYASQTRSESSS-QADTSKSKSEDSAEAYTSRSKSQD 778


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,648,960
Number of Sequences: 37866
Number of extensions: 1953002
Number of successful extensions: 5882
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 5049
Number of HSP's gapped (non-prelim): 605
length of query: 899
length of database: 18,247,518
effective HSP length: 111
effective length of query: 788
effective length of database: 14,044,392
effective search space: 11066980896
effective search space used: 11066980896
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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